ASSAY_ID ASSAY PROJECT PLATE WELL WELL_TYPE RAW_VALUE_A BSUB_VALUE_A Z_SCORE_A RAW_VALUE_B BSUB_VALUE_B Z_SCORE_B COMPOSITE_Z REPRODUCIBILITY CHEMBANK_ID VIRTUAL_ID SMILES RAW_VALUE_C BSUB_VALUE_C Z_SCORE_C 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 A01 compound treatment 101250.0 -465000.0 -2.32 154580.0 -452000.0 -2.13 -3.1445 -0.999 3186889 PK04_093001 COCCCNC(=O)[C@@]1(Cc2ccccc2CN=[N+]=[N-])N=C(O[C@H]1c3ccccc3CN=[N+]=[N-])c4ccc(OCCCO)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 A02 compound treatment 99040.0 -467000.0 -2.33 92370.0 -514000.0 -2.42 -3.3592 -0.9998 3067555 PK04_093002 OCCCOc1ccc(cc1)C2=N[C@@](CCS(=O)(=O)c3ccccc3)([C@@H](O2)c4ccccc4)C(=O)N5CCCCC5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 A03 compound treatment 377190.0 -189000.0 -0.94 165120.0 -442000.0 -2.08 -2.1349 -0.9361 3186890 PK04_093003 CN(C)C(=O)[C@@]1(CC=C)N=C(O[C@H]1c2ccccc2)c3ccc(OCCCO)cc3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 A04 compound treatment 400000.0 -166000.0 -0.83 180160.0 -426000.0 -2.01 -2.0043 -0.9235 3186891 PK04_093004 OCCCOc1ccc(cc1)C2=N[C@](CC=C)([C@H](O2)c3ccccc3N=[N+]=[N-])C(=O)NCC(O)CO 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 A05 compound treatment 120390.0 -445000.0 -2.23 150620.0 -456000.0 -2.14 -3.09 -0.9998 3067558 PK04_093005 OCCCOc1ccc(cc1)C2=N[C@@](CC=C)([C@@H](O2)c3ccccc3N=[N+]=[N-])C(=O)N4CCOCC4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 A06 compound treatment 163360.0 -403000.0 -2.01 201120.0 -406000.0 -1.91 -2.7703 -0.9997 3186892 PK04_093006 OCCCOc1ccc(cc1)C2=N[C@](CC=C)([C@H](O2)c3ccccc3N=[N+]=[N-])C(=O)N4CCOCC4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 A07 compound treatment 153060.0 -413000.0 -2.06 165180.0 -441000.0 -2.08 -2.9262 -1.0 3067559 PK04_093007 OCCCOc1ccc(cc1)C2=N[C@@](Cc3ccccc3CN=[N+]=[N-])([C@@H](O2)c4ccccc4N=[N+]=[N-])C(=O)N5CCCCC5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 A08 compound treatment 255580.0 -310000.0 -1.55 526970.0 -79700.0 -0.37 -1.3609 -0.8535 3186893 PK04_093008 NC(=O)[C@@]1(Cc2ccccc2N=[N+]=[N-])COC(=N1)c3ccc(OCCCO)cc3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 A09 compound treatment 397550.0 -168000.0 -0.84 403900.0 -203000.0 -0.95 -1.2688 -0.998 3186894 PK04_093009 OCCCOc1ccc(cc1)C2=N[C@@](CCS(=O)(=O)c3ccccc3)([C@@H](O2)c4ccccc4)C(=O)NCC(O)CO 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 A10 compound treatment 172870.0 -393000.0 -1.96 194800.0 -412000.0 -1.94 -2.7578 -1.0 3067560 PK04_093010 OCCCOc1ccc(cc1)C2=N[C@](CCS(=O)(=O)c3ccccc3)([C@H](O2)c4ccccc4N=[N+]=[N-])C(=O)N5CCCCC5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 A11 compound treatment 282110.0 -284000.0 -1.42 180120.0 -427000.0 -2.01 -2.4208 -0.9855 3186895 PK04_093011 OCCCOc1ccc(cc1)C2=N[C@](CC=C)([C@H](O2)c3ccccc3CN=[N+]=[N-])C(=O)NCCN4CCOCC4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 A12 compound treatment 266460.0 -299000.0 -1.5 255530.0 -351000.0 -1.65 -2.2252 -0.9988 3186896 PK04_093012 NC(=O)[C@]1(Cc2ccccc2N=[N+]=[N-])N=C(O[C@@H]1c3ccccc3)c4ccc(OCCCO)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 A13 mock treatment 507450.0 -58400.0 -0.29 400250.0 -206000.0 -0.97 -0.8928 -0.8808 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 A14 mock treatment 223950.0 -342000.0 -1.71 511410.0 -95200.0 -0.45 -1.5243 -0.8634 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 A15 compound treatment 132750.0 -433000.0 -2.16 199140.0 -407000.0 -1.92 -2.885 -0.9982 3067562 PK04_093013 CN(C)C(=O)[C@@]1(Cc2ccccc2CN=[N+]=[N-])N=C(O[C@H]1c3ccccc3N=[N+]=[N-])c4ccc(OCCCO)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 A16 compound treatment 212640.0 -353000.0 -1.76 236170.0 -370000.0 -1.74 -2.4797 -1.0 3186897 PK04_093014 OCCCOc1ccc(cc1)C2=N[C@](CC=C)([C@H](O2)c3ccccc3CN=[N+]=[N-])C(=O)N4CCCCC4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 A17 compound treatment 424530.0 -141000.0 -0.71 529830.0 -76800.0 -0.36 -0.7547 -0.9516 3067564 PK04_093015 NC(=O)[C@]1(CC=C)N=C(O[C@@H]1c2ccccc2CN=[N+]=[N-])c3ccc(OCCCO)cc3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 A18 compound treatment 130810.0 -435000.0 -2.17 143540.0 -463000.0 -2.18 -3.0768 -1.0 3186898 PK04_093016 OCCCOc1ccc(cc1)C2=N[C@](CC=C)([C@H](O2)c3ccccc3N=[N+]=[N-])C(=O)N4CCCCC4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 A19 compound treatment 108850.0 -457000.0 -2.28 124250.0 -482000.0 -2.27 -3.2185 -1.0 3186899 PK04_093017 COCCCNC(=O)[C@@]1(Cc2ccccc2N=[N+]=[N-])N=C(O[C@H]1c3ccccc3CN=[N+]=[N-])c4ccc(OCCCO)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 A20 compound treatment 205050.0 -361000.0 -1.8 179430.0 -427000.0 -2.01 -2.6952 -0.9985 3067604 PK04_093018 COCCCNC(=O)[C@]1(Cc2ccccc2N=[N+]=[N-])N=C(O[C@@H]1c3ccccc3CN=[N+]=[N-])c4ccc(OCCCO)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 A21 compound treatment 265010.0 -301000.0 -1.5 413730.0 -193000.0 -0.91 -1.7042 -0.9708 3186900 PK04_093019 OCCCOc1ccc(cc1)C2=N[C@@](Cc3ccccc3CN=[N+]=[N-])([C@@H](O2)c4ccccc4CN=[N+]=[N-])C(=O)NCc5ccccc5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 A22 compound treatment 256180.0 -310000.0 -1.55 304670.0 -302000.0 -1.42 -2.0981 -0.9991 3067607 PK04_093020 OCCCOc1ccc(cc1)C2=N[C@@](CCS(=O)(=O)c3ccccc3)([C@@H](O2)c4ccccc4CN=[N+]=[N-])C(=O)N5CCOCC5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 A23 compound treatment 227070.0 -339000.0 -1.69 415970.0 -191000.0 -0.9 -1.8307 -0.9559 3186901 PK04_093021 NC(=O)[C@@]1(CC=C)N=C(O[C@H]1c2ccccc2CN=[N+]=[N-])c3ccc(OCCCO)cc3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 A24 compound treatment 281280.0 -285000.0 -1.42 188810.0 -418000.0 -1.97 -2.3948 -0.9874 3186902 PK04_093022 NC(=O)[C@@]1(Cc2ccccc2CN=[N+]=[N-])N=C(O[C@H]1c3ccccc3CN=[N+]=[N-])c4ccc(OCCCO)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 B01 compound treatment 406370.0 -160000.0 -0.8 164800.0 -442000.0 -2.08 -2.0329 -0.9134 3067612 PK04_093023 COC(=O)[C@@]1(CC=C)N=C(O[C@H]1c2ccccc2)c3ccc(OCCCO)cc3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 B02 compound treatment 583550.0 17700.0 0.09 583210.0 -23400.0 -0.11 -0.0155 -0.1101 3186903 PK04_093024 NC(=O)[C@@]1(Cc2ccccc2)N=C(O[C@H]1c3ccccc3CN=[N+]=[N-])c4ccc(OCCCO)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 B03 compound treatment 290560.0 -275000.0 -1.38 439310.0 -167000.0 -0.79 -1.5289 -0.9649 3067614 PK04_093025 OCCCOc1ccc(cc1)C2=N[C@@](Cc3ccccc3CN=[N+]=[N-])([C@@H](O2)c4ccccc4N=[N+]=[N-])C(=O)O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 B04 compound treatment 449600.0 -116000.0 -0.58 317600.0 -289000.0 -1.36 -1.372 -0.928 3186904 PK04_093026 OCCCOc1ccc(cc1)C2=N[C@](CCS(=O)(=O)c3ccccc3)([C@H](O2)c4ccccc4)C(=O)NCCN5CCOCC5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 B05 compound treatment 142410.0 -423000.0 -2.12 236050.0 -371000.0 -1.74 -2.7281 -0.9954 3186905 PK04_093027 COC(=O)[C@]1(CC=C)N=C(O[C@@H]1c2ccccc2N=[N+]=[N-])c3ccc(OCCCO)cc3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 B06 compound treatment 525220.0 -40700.0 -0.2 559890.0 -46700.0 -0.22 -0.2991 -0.9992 3068180 PK04_093028 COCCCNC(=O)[C@@]1(CCC(=O)OC(C)(C)C)N=C(O[C@H]1c2ccccc2CN=[N+]=[N-])c3ccc(OCCCO)cc3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 B07 compound treatment 400070.0 -166000.0 -0.83 311640.0 -295000.0 -1.39 -1.5668 -0.9696 3186906 PK04_093029 COC(=O)[C@H]1N=C(O[C@H]1c2ccccc2N=[N+]=[N-])c3ccc(OCCCO)cc3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 B08 compound treatment 100820.0 -465000.0 -2.32 96850.0 -510000.0 -2.4 -3.338 -0.9999 3186992 PK04_093030 COCCCNC(=O)[C@@]1(Cc2ccccc2N=[N+]=[N-])N=C(O[C@H]1c3ccccc3N=[N+]=[N-])c4ccc(OCCCO)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 B09 compound treatment 258280.0 -308000.0 -1.54 234080.0 -373000.0 -1.75 -2.3255 -0.9978 3068181 PK04_093031 COC(=O)[C@@]1(CC=C)N=C(O[C@H]1c2ccccc2N=[N+]=[N-])c3ccc(OCCCO)cc3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 B10 compound treatment 192610.0 -373000.0 -1.86 171240.0 -435000.0 -2.05 -2.7664 -0.9989 3186993 PK04_093032 OCCCOc1ccc(cc1)C2=N[C@@](CC=C)([C@@H](O2)c3ccccc3N=[N+]=[N-])C(=O)N4CCCCC4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 B11 compound treatment 129520.0 -436000.0 -2.18 154080.0 -453000.0 -2.13 -3.0463 -0.9999 3068182 PK04_093033 COC(=O)[C@]1(CCS(=O)(=O)c2ccccc2)N=C(O[C@@H]1c3ccccc3N=[N+]=[N-])c4ccc(OCCCO)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 B12 compound treatment 417060.0 -149000.0 -0.74 352000.0 -255000.0 -1.2 -1.3725 -0.9737 3186994 PK04_093034 OCCCOc1ccc(cc1)C2=N[C@](CCS(=O)(=O)c3ccccc3)([C@H](O2)c4ccccc4CN=[N+]=[N-])C(=O)N5CCCCC5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 B13 mock treatment 523050.0 -42800.0 -0.21 582620.0 -24000.0 -0.11 -0.2312 -0.9554 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 B14 mock treatment 552040.0 -13800.0 -0.07 600480.0 -6160.0 -0.03 -0.0694 -0.9253 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 B15 compound treatment 526650.0 -39200.0 -0.2 578160.0 -28500.0 -0.13 -0.2333 -0.9828 3068183 PK04_093035 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3N=[N+]=[N-])(CO2)C(=O)O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 B16 compound treatment 336760.0 -229000.0 -1.14 289820.0 -317000.0 -1.49 -1.8629 -0.9915 3186995 PK04_093036 NC(=O)[C@]1(Cc2ccccc2)N=C(O[C@@H]1c3ccccc3)c4ccc(OCCCO)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 B17 compound treatment 139730.0 -426000.0 -2.13 153120.0 -454000.0 -2.13 -3.0134 -1.0 3186996 PK04_093037 COC(=O)[C@]1(Cc2ccccc2)N=C(O[C@@H]1c3ccccc3CN=[N+]=[N-])c4ccc(OCCCO)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 B18 compound treatment 450730.0 -115000.0 -0.58 509660.0 -97000.0 -0.46 -0.7292 -0.9934 3068184 PK04_093038 OCCCOc1ccc(cc1)C2=N[C@](CCS(=O)(=O)c3ccccc3)([C@H](O2)c4ccccc4CN=[N+]=[N-])C(=O)NCC(O)CO 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 B19 compound treatment 252380.0 -314000.0 -1.57 279090.0 -328000.0 -1.54 -2.1966 -1.0 3186997 PK04_093039 COC(=O)[C@@]1(CCC(=O)OC(C)(C)C)N=C(O[C@H]1c2ccccc2)c3ccc(OCCCO)cc3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 B20 compound treatment 216740.0 -349000.0 -1.74 200060.0 -407000.0 -1.91 -2.5853 -0.9989 3186998 PK04_093040 CC(C)(C)OC(=O)CC[C@]1(N=C(O[C@@H]1c2ccccc2N=[N+]=[N-])c3ccc(OCCCO)cc3)C(=O)NCc4ccccc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 B21 compound treatment 326080.0 -240000.0 -1.2 391450.0 -215000.0 -1.01 -1.5626 -0.9965 3068185 PK04_093041 OCCCOc1ccc(cc1)C2=N[C@@](Cc3ccccc3N=[N+]=[N-])([C@@H](O2)c4ccccc4CN=[N+]=[N-])C(=O)O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 B22 compound treatment 483840.0 -82000.0 -0.41 541860.0 -64800.0 -0.3 -0.5052 -0.9894 3186999 PK04_093042 CN(C)C(=O)[C@@]1(CC=C)COC(=N1)c2ccc(OCCCO)cc2 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 B23 compound treatment 351590.0 -214000.0 -1.07 404560.0 -202000.0 -0.95 -1.4289 -0.9982 3068186 PK04_093043 OCCCOc1ccc(cc1)C2=N[C@@](CC=C)([C@@H](O2)c3ccccc3)C(=O)O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 B24 compound treatment 191120.0 -375000.0 -1.87 155140.0 -451000.0 -2.12 -2.8252 -0.998 3187000 PK04_093044 CC(C)(C)OC(=O)CC[C@@]1(N=C(O[C@H]1c2ccccc2N=[N+]=[N-])c3ccc(OCCCO)cc3)C(=O)NCc4ccccc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 C01 compound treatment 65370.0 -501000.0 -2.5 64640.0 -542000.0 -2.55 -3.5703 -1.0 3187001 PK04_093045 CN(C)C(=O)[C@@]1(Cc2ccccc2)N=C(O[C@H]1c3ccccc3N=[N+]=[N-])c4ccc(OCCCO)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 C02 compound treatment 185760.0 -380000.0 -1.9 296860.0 -310000.0 -1.46 -2.3728 -0.9915 3068187 PK04_093046 CN(C)C(=O)[C@]1(CCS(=O)(=O)c2ccccc2)N=C(O[C@@H]1c3ccccc3)c4ccc(OCCCO)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 C03 compound treatment 185670.0 -380000.0 -1.9 340480.0 -266000.0 -1.25 -2.228 -0.9796 3187002 PK04_093047 COCCCNC(=O)[C@]1(CCC(=O)OC(C)(C)C)N=C(O[C@@H]1c2ccccc2N=[N+]=[N-])c3ccc(OCCCO)cc3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 C04 compound treatment 387640.0 -178000.0 -0.89 218040.0 -389000.0 -1.83 -1.922 -0.9453 3068188 PK04_093048 NC(=O)[C@]1(CCS(=O)(=O)c2ccccc2)N=C(O[C@@H]1c3ccccc3)c4ccc(OCCCO)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 C05 compound treatment 213700.0 -352000.0 -1.76 416650.0 -190000.0 -0.89 -1.8757 -0.9507 3187003 PK04_093049 NC(=O)[C@@]1(CCS(=O)(=O)c2ccccc2)N=C(O[C@H]1c3ccccc3N=[N+]=[N-])c4ccc(OCCCO)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 C06 compound treatment 247240.0 -319000.0 -1.59 276180.0 -330000.0 -1.55 -2.2244 -0.9999 3187004 PK04_093050 CN(C)C(=O)[C@]1(CCS(=O)(=O)c2ccccc2)N=C(O[C@@H]1c3ccccc3CN=[N+]=[N-])c4ccc(OCCCO)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 C07 compound treatment 520880.0 -45000.0 -0.22 380020.0 -227000.0 -1.07 -0.9127 -0.8378 3068189 PK04_093051 NC(=O)[C@]1(CCS(=O)(=O)c2ccccc2)N=C(O[C@@H]1c3ccccc3CN=[N+]=[N-])c4ccc(OCCCO)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 C08 compound treatment 396090.0 -170000.0 -0.85 453370.0 -153000.0 -0.72 -1.1094 -0.9967 3187005 PK04_093052 OCCCOc1ccc(cc1)C2=N[C@@](CCS(=O)(=O)c3ccccc3)([C@@H](O2)c4ccccc4)C(=O)NCCN5CCOCC5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 C09 compound treatment 397310.0 -169000.0 -0.84 447910.0 -159000.0 -0.75 -1.1233 -0.9982 3187006 PK04_093053 CC(C)(C)OC(=O)CC[C@@]1(N=C(O[C@H]1c2ccccc2N=[N+]=[N-])c3ccc(OCCCO)cc3)C(=O)NCCN4CCOCC4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 C10 compound treatment 121380.0 -445000.0 -2.22 124810.0 -482000.0 -2.27 -3.1724 -0.9999 3068190 PK04_093054 CN(C)C(=O)[C@@]1(Cc2ccccc2N=[N+]=[N-])N=C(O[C@H]1c3ccccc3)c4ccc(OCCCO)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 C11 mock treatment 514650.0 -51200.0 -0.26 584350.0 -22300.0 -0.1 -0.2551 -0.9224 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 C12 mock treatment 471250.0 -94600.0 -0.47 578030.0 -28600.0 -0.13 -0.4294 -0.8737 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 C13 compound treatment 113980.0 -452000.0 -2.26 188920.0 -418000.0 -1.96 -2.9853 -0.9976 3187007 PK04_093055 COC(=O)[C@]1(Cc2ccccc2)N=C(O[C@@H]1c3ccccc3N=[N+]=[N-])c4ccc(OCCCO)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 C14 compound treatment 209990.0 -356000.0 -1.78 279890.0 -327000.0 -1.54 -2.3437 -0.9974 3068191 PK04_093056 CC(C)(C)OC(=O)CC[C@]1(N=C(O[C@@H]1c2ccccc2)c3ccc(OCCCO)cc3)C(=O)N4CCCCC4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 C15 mock treatment 529840.0 -36000.0 -0.18 585250.0 -21400.0 -0.1 -0.1984 -0.9622 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 C16 mock treatment 490730.0 -75200.0 -0.38 528410.0 -78200.0 -0.37 -0.5256 -0.9999 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 C17 compound treatment 185710.0 -380000.0 -1.9 363210.0 -243000.0 -1.14 -2.1523 -0.9707 3187008 PK04_093057 COC(=O)[C@@]1(Cc2ccccc2CN=[N+]=[N-])N=C(O[C@H]1c3ccccc3CN=[N+]=[N-])c4ccc(OCCCO)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 C18 compound treatment 202180.0 -364000.0 -1.82 190430.0 -416000.0 -1.96 -2.6688 -0.9993 3068193 PK04_093058 COCCCNC(=O)[C@@]1(CC=C)N=C(O[C@H]1c2ccccc2N=[N+]=[N-])c3ccc(OCCCO)cc3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 C19 compound treatment 199770.0 -366000.0 -1.83 184500.0 -422000.0 -1.99 -2.697 -0.9992 3187009 PK04_093059 COC(=O)[C@@]1(Cc2ccccc2)N=C(O[C@H]1c3ccccc3)c4ccc(OCCCO)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 C20 compound treatment 150970.0 -415000.0 -2.07 141870.0 -465000.0 -2.19 -3.0112 -0.9996 3187010 PK04_093060 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3)([C@H](O2)c4ccccc4CN=[N+]=[N-])C(=O)NCCN5CCOCC5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 C21 compound treatment 221440.0 -344000.0 -1.72 326290.0 -280000.0 -1.32 -2.1489 -0.9914 3068197 PK04_093061 OCCCOc1ccc(cc1)C2=N[C@@](Cc3ccccc3N=[N+]=[N-])([C@@H](O2)c4ccccc4N=[N+]=[N-])C(=O)O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 C22 compound treatment 316370.0 -250000.0 -1.25 282330.0 -324000.0 -1.53 -1.9598 -0.995 3187011 PK04_093062 OCCCOc1ccc(cc1)C2=N[C@@](Cc3ccccc3)([C@@H](O2)c4ccccc4)C(=O)NCC(O)CO 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 C23 compound treatment 424870.0 -141000.0 -0.7 495890.0 -111000.0 -0.52 -0.8664 -0.989 3068199 PK04_093063 COC(=O)[C@@]1(CCC(=O)OC(C)(C)C)COC(=N1)c2ccc(OCCCO)cc2 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 C24 compound treatment 376680.0 -189000.0 -0.95 510450.0 -96200.0 -0.45 -0.9881 -0.9431 3187012 PK04_093064 OCCCOc1ccc(cc1)C2=N[C@](CC=C)(CO2)C(=O)N3CCCCC3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 D01 compound treatment 490240.0 -75600.0 -0.38 455260.0 -151000.0 -0.71 -0.7706 -0.9561 3187091 PK04_093065 OCCCOc1ccc(cc1)C2=N[C@](CC=C)([C@H](O2)c3ccccc3CN=[N+]=[N-])C(=O)O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 D02 compound treatment 445120.0 -121000.0 -0.6 338330.0 -268000.0 -1.26 -1.3189 -0.9429 3068202 PK04_093066 CN(C)C(=O)[C@]1(CCC(=O)OC(C)(C)C)N=C(O[C@@H]1c2ccccc2CN=[N+]=[N-])c3ccc(OCCCO)cc3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 D03 compound treatment 527120.0 -38800.0 -0.19 581080.0 -25600.0 -0.12 -0.2219 -0.9737 3187092 PK04_093067 OCCCOc1ccc(cc1)C2=N[C@@](CCS(=O)(=O)c3ccccc3)([C@@H](O2)c4ccccc4)C(=O)O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 D04 compound treatment 390600.0 -175000.0 -0.88 174810.0 -432000.0 -2.03 -2.0553 -0.9292 3187093 PK04_093068 OCCCOc1ccc(cc1)C2=N[C@@](Cc3ccccc3)([C@@H](O2)c4ccccc4)C(=O)NCc5ccccc5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 D05 compound treatment 199360.0 -367000.0 -1.83 223570.0 -383000.0 -1.8 -2.5685 -1.0 3068220 PK04_093069 COC(=O)[C@@]1(CCS(=O)(=O)c2ccccc2)N=C(O[C@H]1c3ccccc3N=[N+]=[N-])c4ccc(OCCCO)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 D06 compound treatment 188120.0 -378000.0 -1.89 172960.0 -434000.0 -2.04 -2.7765 -0.9992 3187094 PK04_093070 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3CN=[N+]=[N-])([C@H](O2)c4ccccc4N=[N+]=[N-])C(=O)NCC(O)CO 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 D07 compound treatment 570830.0 4940.0 0.02 648960.0 42300.0 0.2 0.1582 0.7887 3068223 PK04_093071 COC(=O)[C@H]1COC(=N1)c2ccc(OCCCO)cc2 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 D08 compound treatment 190560.0 -375000.0 -1.87 143520.0 -463000.0 -2.18 -2.8658 -0.9972 3187095 PK04_093072 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3)([C@H](O2)c4ccccc4N=[N+]=[N-])C(=O)N5CCOCC5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 D09 compound treatment 451910.0 -114000.0 -0.57 254880.0 -352000.0 -1.65 -1.5725 -0.8987 3068225 PK04_093073 COC(=O)[C@@]1(Cc2ccccc2CN=[N+]=[N-])N=C(O[C@H]1c3ccccc3)c4ccc(OCCCO)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 D10 compound treatment 533280.0 -32600.0 -0.16 690150.0 83500.0 0.39 0.1626 0.3824 3187096 PK04_093074 CC(C)(C)OC(=O)CC[C@@]1(N=C(O[C@H]1c2ccccc2CN=[N+]=[N-])c3ccc(OCCCO)cc3)C(=O)NCC(O)CO 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 D11 mock treatment 489140.0 -76700.0 -0.38 621440.0 14800.0 0.07 -0.2218 -0.5693 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 D12 mock treatment 543920.0 -22000.0 -0.11 679530.0 72900.0 0.34 0.1649 0.4579 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 D13 compound treatment 277730.0 -288000.0 -1.44 272190.0 -334000.0 -1.57 -2.13 -0.999 3187097 PK04_093075 COC(=O)[C@@]1(CCC(=O)OC(C)(C)C)N=C(O[C@H]1c2ccccc2N=[N+]=[N-])c3ccc(OCCCO)cc3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 D14 compound treatment 394590.0 -171000.0 -0.86 373620.0 -233000.0 -1.1 -1.38 -0.9925 3068228 PK04_093076 OCCCOc1ccc(cc1)C2=N[C@@](CC=C)([C@@H](O2)c3ccccc3N=[N+]=[N-])C(=O)NCc4ccccc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 D15 mock treatment 537600.0 -28300.0 -0.14 601600.0 -5040.0 -0.02 -0.1167 -0.8143 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 D16 mock treatment 567170.0 1280.0 0.01 652910.0 46300.0 0.22 0.1584 0.7276 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 D17 compound treatment 558740.0 -7150.0 -0.04 628800.0 22200.0 0.1 0.0485 0.4399 3187098 PK04_093077 COC(=O)[C@@]1(Cc2ccccc2CN=[N+]=[N-])COC(=N1)c3ccc(OCCCO)cc3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 D18 compound treatment 515680.0 -50200.0 -0.25 329450.0 -277000.0 -1.3 -1.0992 -0.8279 3187099 PK04_093078 OCCCOc1ccc(cc1)C2=N[C@@](CC=C)([C@@H](O2)c3ccccc3N=[N+]=[N-])C(=O)NCC(O)CO 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 D19 compound treatment 442720.0 -123000.0 -0.62 227220.0 -379000.0 -1.78 -1.6969 -0.8989 3068229 PK04_093079 OCCCOc1ccc(cc1)C2=N[C@](CCS(=O)(=O)c3ccccc3)([C@H](O2)c4ccccc4N=[N+]=[N-])C(=O)O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 D20 compound treatment 467480.0 -98400.0 -0.49 413630.0 -193000.0 -0.91 -0.9895 -0.9585 3187100 PK04_093080 OCCCOc1ccc(cc1)C2=N[C@@](CC=C)([C@@H](O2)c3ccccc3N=[N+]=[N-])C(=O)NCCN4CCOCC4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 D21 compound treatment 411840.0 -154000.0 -0.77 187580.0 -419000.0 -1.97 -1.9378 -0.9158 3068232 PK04_093081 COC(=O)[C@]1(CCC(=O)OC(C)(C)C)N=C(O[C@@H]1c2ccccc2)c3ccc(OCCCO)cc3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 D22 compound treatment 482120.0 -83800.0 -0.42 524320.0 -82300.0 -0.39 -0.5696 -0.9993 3187101 PK04_093082 OCCCOc1ccc(cc1)C2=N[C@](CC=C)([C@H](O2)c3ccccc3)C(=O)NCC(O)CO 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 D23 compound treatment 238500.0 -327000.0 -1.64 184980.0 -422000.0 -1.98 -2.5586 -0.9954 3187102 PK04_093083 COC(=O)[C@@]1(CC=C)N=C(O[C@H]1c2ccccc2CN=[N+]=[N-])c3ccc(OCCCO)cc3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 D24 compound treatment 393950.0 -172000.0 -0.86 225380.0 -381000.0 -1.79 -1.8753 -0.9432 3068234 PK04_093084 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3)([C@H](O2)c4ccccc4)C(=O)NCC(O)CO 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 E01 mock treatment 621440.0 55600.0 0.28 593870.0 -12800.0 -0.06 0.1537 0.5415 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 E02 mock treatment 661280.0 95400.0 0.48 613500.0 6860.0 0.03 0.3597 0.7533 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 E03 compound treatment 502940.0 -62900.0 -0.31 499420.0 -107000.0 -0.5 -0.5789 -0.9741 3187103 PK04_093085 COC(=O)[C@H]1N=C(O[C@H]1c2ccccc2CN=[N+]=[N-])c3ccc(OCCCO)cc3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 E04 compound treatment 358370.0 -208000.0 -1.04 193240.0 -413000.0 -1.94 -2.1078 -0.9566 3187104 PK04_093086 OCCCOc1ccc(cc1)C2=N[C@@](Cc3ccccc3N=[N+]=[N-])([C@@H](O2)c4ccccc4)C(=O)NCc5ccccc5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 E05 compound treatment 564710.0 -1180.0 -0.01 306630.0 -300000.0 -1.41 -1.002 -0.7101 3068237 PK04_093087 CC(C)(C)OC(=O)CC[C@]1(N=C(O[C@@H]1c2ccccc2)c3ccc(OCCCO)cc3)C(=O)O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 E06 compound treatment 543060.0 -22800.0 -0.11 598500.0 -8140.0 -0.04 -0.1077 -0.8953 3187105 PK04_093088 OCCCOc1ccc(cc1)C2=N[C@](CCS(=O)(=O)c3ccccc3)(CO2)C(=O)NCC(O)CO 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 E07 compound treatment 164200.0 -402000.0 -2.01 224340.0 -382000.0 -1.8 -2.6901 -0.9985 3068240 PK04_093089 COC(=O)[C@]1(Cc2ccccc2N=[N+]=[N-])N=C(O[C@@H]1c3ccccc3CN=[N+]=[N-])c4ccc(OCCCO)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 E08 compound treatment 292960.0 -273000.0 -1.36 229150.0 -377000.0 -1.78 -2.2194 -0.9915 3187106 PK04_093090 CN(C)C(=O)[C@@]1(Cc2ccccc2CN=[N+]=[N-])N=C(O[C@H]1c3ccccc3CN=[N+]=[N-])c4ccc(OCCCO)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 E09 mock treatment 589670.0 23800.0 0.12 603100.0 -3540.0 -0.02 0.0722 0.6022 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 E10 mock treatment 592580.0 26700.0 0.13 703040.0 96400.0 0.45 0.4149 0.8778 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 E11 compound treatment 263480.0 -302000.0 -1.51 442240.0 -164000.0 -0.77 -1.6148 -0.9517 3068242 PK04_093091 COC(=O)[C@@]1(Cc2ccccc2N=[N+]=[N-])COC(=N1)c3ccc(OCCCO)cc3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 E12 compound treatment 175450.0 -390000.0 -1.95 321470.0 -285000.0 -1.34 -2.3273 -0.9833 3187107 PK04_093092 OCCCOc1ccc(cc1)C2=N[C@@](CCS(=O)(=O)c3ccccc3)([C@@H](O2)c4ccccc4N=[N+]=[N-])C(=O)N5CCCCC5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 E13 compound treatment 428810.0 -137000.0 -0.68 223600.0 -383000.0 -1.8 -1.7581 -0.9122 3068264 PK04_093093 COC(=O)[C@@]1(Cc2ccccc2N=[N+]=[N-])N=C(O[C@H]1c3ccccc3)c4ccc(OCCCO)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 E14 compound treatment 210600.0 -355000.0 -1.77 303700.0 -303000.0 -1.42 -2.2623 -0.9941 3187108 PK04_093094 OCCCOc1ccc(cc1)C2=N[C@@](Cc3ccccc3)([C@@H](O2)c4ccccc4)C(=O)N5CCOCC5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 E15 compound treatment 309530.0 -256000.0 -1.28 264930.0 -342000.0 -1.61 -2.0419 -0.9937 3187109 PK04_093095 COC(=O)[C@@]1(Cc2ccccc2CN=[N+]=[N-])N=C(O[C@H]1c3ccccc3N=[N+]=[N-])c4ccc(OCCCO)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 E16 compound treatment 294740.0 -271000.0 -1.35 378080.0 -229000.0 -1.08 -1.7178 -0.9935 3068267 PK04_093096 OCCCOc1ccc(cc1)C2=N[C@](CC=C)([C@H](O2)c3ccccc3N=[N+]=[N-])C(=O)NCc4ccccc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 E17 mock treatment 611360.0 45500.0 0.23 691200.0 84600.0 0.4 0.4418 0.9647 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 E18 mock treatment 574330.0 8440.0 0.04 608520.0 1880.0 0.01 0.0361 0.8375 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 E19 compound treatment 496680.0 -69200.0 -0.35 650470.0 43800.0 0.21 -0.0986 -0.245 3187110 PK04_093097 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3)(CO2)C(=O)O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 E20 compound treatment 242750.0 -323000.0 -1.61 301600.0 -305000.0 -1.43 -2.1558 -0.9983 3187111 PK04_093098 OCCCOc1ccc(cc1)C2=N[C@@](Cc3ccccc3)([C@@H](O2)c4ccccc4CN=[N+]=[N-])C(=O)NCCN5CCOCC5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 E21 compound treatment 332000.0 -234000.0 -1.17 539360.0 -67300.0 -0.32 -1.0498 -0.8674 3068269 PK04_093099 OCCCOc1ccc(cc1)C2=N[C@@](Cc3ccccc3)([C@@H](O2)c4ccccc4N=[N+]=[N-])C(=O)O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 E22 compound treatment 213440.0 -352000.0 -1.76 289280.0 -317000.0 -1.49 -2.3002 -0.9966 3187184 PK04_093100 OCCCOc1ccc(cc1)C2=N[C@](CCS(=O)(=O)c3ccccc3)([C@H](O2)c4ccccc4)C(=O)N5CCOCC5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 E23 compound treatment 315200.0 -251000.0 -1.25 202720.0 -404000.0 -1.9 -2.2288 -0.9795 3068272 PK04_093101 COC(=O)[C@]1(CC=C)N=C(O[C@@H]1c2ccccc2)c3ccc(OCCCO)cc3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 E24 compound treatment 228370.0 -338000.0 -1.69 204560.0 -402000.0 -1.89 -2.5293 -0.9984 3187185 PK04_093102 OCCCOc1ccc(cc1)C2=N[C@@](Cc3ccccc3CN=[N+]=[N-])([C@@H](O2)c4ccccc4)C(=O)NCc5ccccc5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 F01 mock treatment 448250.0 -118000.0 -0.59 545140.0 -61500.0 -0.29 -0.62 -0.9467 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 F02 mock treatment 653560.0 87700.0 0.44 639270.0 32600.0 0.15 0.4182 0.9012 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 F03 compound treatment 355110.0 -211000.0 -1.05 188410.0 -418000.0 -1.97 -2.1354 -0.9571 3068274 PK04_093103 COC(=O)[C@]1(CCC(=O)OC(C)(C)C)N=C(O[C@@H]1c2ccccc2N=[N+]=[N-])c3ccc(OCCCO)cc3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 F04 compound treatment 359040.0 -207000.0 -1.03 137090.0 -470000.0 -2.21 -2.2922 -0.9401 3187186 PK04_093104 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3CN=[N+]=[N-])([C@H](O2)c4ccccc4CN=[N+]=[N-])C(=O)NCCN5CCOCC5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 F05 compound treatment 124040.0 -442000.0 -2.21 153510.0 -453000.0 -2.13 -3.0675 -0.9998 3068276 PK04_093105 COC(=O)[C@]1(Cc2ccccc2)N=C(O[C@@H]1c3ccccc3)c4ccc(OCCCO)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 F06 compound treatment 206690.0 -359000.0 -1.79 466520.0 -140000.0 -0.66 -1.7346 -0.9076 3187187 PK04_093106 NC(=O)[C@@]1(Cc2ccccc2N=[N+]=[N-])N=C(O[C@H]1c3ccccc3CN=[N+]=[N-])c4ccc(OCCCO)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 F07 compound treatment 237760.0 -328000.0 -1.64 226730.0 -380000.0 -1.79 -2.4224 -0.9991 3187188 PK04_093107 COC(=O)[C@@]1(CCS(=O)(=O)c2ccccc2)N=C(O[C@H]1c3ccccc3)c4ccc(OCCCO)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 F08 compound treatment 332270.0 -234000.0 -1.17 127520.0 -479000.0 -2.25 -2.4186 -0.953 3068278 PK04_093108 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3N=[N+]=[N-])([C@H](O2)c4ccccc4CN=[N+]=[N-])C(=O)NCCN5CCOCC5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 F09 mock treatment 577600.0 11700.0 0.06 700820.0 94200.0 0.44 0.3546 0.7936 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 F10 mock treatment 567270.0 1380.0 0.01 665570.0 58900.0 0.28 0.2009 0.7245 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 F11 compound treatment 444850.0 -121000.0 -0.6 557160.0 -49500.0 -0.23 -0.592 -0.9139 3187189 PK04_093109 COC(=O)[C@]1(CCC(=O)OC(C)(C)C)N=C(O[C@@H]1c2ccccc2CN=[N+]=[N-])c3ccc(OCCCO)cc3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 F12 compound treatment 560230.0 -5660.0 -0.03 657130.0 50500.0 0.24 0.148 0.6186 3068280 PK04_093110 CC(C)(C)OC(=O)CC[C@@]1(N=C(O[C@H]1c2ccccc2)c3ccc(OCCCO)cc3)C(=O)N 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 F13 compound treatment 267780.0 -298000.0 -1.49 237570.0 -369000.0 -1.74 -2.2803 -0.9971 3187190 PK04_093111 COC(=O)[C@]1(Cc2ccccc2CN=[N+]=[N-])N=C(O[C@@H]1c3ccccc3)c4ccc(OCCCO)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 F14 compound treatment 419720.0 -146000.0 -0.73 206640.0 -400000.0 -1.88 -1.8466 -0.915 3187191 PK04_093112 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3N=[N+]=[N-])([C@H](O2)c4ccccc4CN=[N+]=[N-])C(=O)N5CCOCC5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 F15 compound treatment 184770.0 -381000.0 -1.9 216320.0 -390000.0 -1.84 -2.6442 -0.9998 3068282 PK04_093113 COC(=O)[C@]1(CCS(=O)(=O)c2ccccc2)N=C(O[C@@H]1c3ccccc3CN=[N+]=[N-])c4ccc(OCCCO)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 F16 compound treatment 351720.0 -214000.0 -1.07 218360.0 -388000.0 -1.83 -2.0478 -0.9675 3187192 PK04_093114 OCCCOc1ccc(cc1)C2=N[C@](CC=C)([C@H](O2)c3ccccc3CN=[N+]=[N-])C(=O)NCc4ccccc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 F17 mock treatment 607610.0 41700.0 0.21 461090.0 -146000.0 -0.68 -0.3367 -0.4706 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 F18 mock treatment 605790.0 39900.0 0.2 588960.0 -17700.0 -0.08 0.0821 0.3803 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 F19 compound treatment 229410.0 -336000.0 -1.68 205320.0 -401000.0 -1.89 -2.5231 -0.9983 3187193 PK04_093115 CC(C)(C)OC(=O)CC[C@]12N=C(O[C@@H]2c3ccccc3CN(CCS(=O)(=O)c4ccccc4)C1=O)c5ccc(OCCCO)cc5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 F20 compound treatment 608380.0 42500.0 0.21 629760.0 23100.0 0.11 0.227 0.9518 3068312 PK04_093116 NC(=O)[C@@]1(Cc2ccccc2)COC(=N1)c3ccc(OCCCO)cc3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 F21 compound treatment 302360.0 -264000.0 -1.32 486400.0 -120000.0 -0.57 -1.3306 -0.9288 3068314 PK04_093117 OCCCOc1ccc(cc1)C2=N[C@]3(CCS(=O)(=O)c4ccccc4)[C@H](O2)c5ccccc5N(CCS(=O)(=O)c6ccccc6)C3=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 F22 compound treatment 531840.0 -34000.0 -0.17 595680.0 -11000.0 -0.05 -0.1567 -0.8818 3187194 PK04_093118 CC(C)(C)OC(=O)CC[C@@]1(N=C(O[C@H]1c2ccccc2CN=[N+]=[N-])c3ccc(OCCCO)cc3)C(=O)N 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 F23 compound treatment 287840.0 -278000.0 -1.39 199040.0 -408000.0 -1.92 -2.3376 -0.9875 3187195 PK04_093119 OCCCOc1ccc(cc1)C2=N[C@@]3(Cc4ccccc4)[C@@H](O2)c5ccccc5CN(CCS(=O)(=O)c6ccccc6)C3=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 F24 compound treatment 195520.0 -370000.0 -1.85 315840.0 -291000.0 -1.37 -2.2752 -0.989 3068317 PK04_093120 CC(C)(C)OC(=O)CC[C@]1(N=C(O[C@@H]1c2ccccc2)c3ccc(OCCCO)cc3)C(=O)N4CCOCC4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 G01 compound treatment 494760.0 -71100.0 -0.36 307250.0 -299000.0 -1.41 -1.247 -0.8586 3187196 PK04_093121 COC(=O)[C@@H]1N=C(O[C@@H]1c2ccccc2)c3ccc(OCCCO)cc3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 G02 compound treatment 574210.0 8320.0 0.04 554240.0 -52400.0 -0.25 -0.1449 -0.5797 3068319 PK04_093122 CC(C)(C)OC(=O)CC[C@@]1(COC(=N1)c2ccc(OCCCO)cc2)C(=O)N3CCCCC3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 G03 mock treatment 618880.0 53000.0 0.26 636210.0 29600.0 0.14 0.2855 0.9549 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 G04 mock treatment 647870.0 82000.0 0.41 664800.0 58200.0 0.27 0.483 0.9808 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 G05 compound treatment 547720.0 -18200.0 -0.09 606880.0 244.0 0.0 -0.0634 -0.6981 3187197 PK04_093123 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3N=[N+]=[N-])([C@H](O2)c4ccccc4)C(=O)O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 G06 compound treatment 174630.0 -391000.0 -1.95 202190.0 -404000.0 -1.9 -2.727 -0.9999 3187198 PK04_093124 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3CN=[N+]=[N-])([C@H](O2)c4ccccc4CN=[N+]=[N-])C(=O)NCC(O)CO 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 G07 compound treatment 553770.0 -12100.0 -0.06 599520.0 -7120.0 -0.03 -0.0665 -0.961 3068323 PK04_093125 OCCCOc1ccc(cc1)C2=N[C@@](Cc3ccccc3CN=[N+]=[N-])([C@@H](O2)c4ccccc4)C(=O)O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 G08 compound treatment 377460.0 -188000.0 -0.94 307420.0 -299000.0 -1.41 -1.6606 -0.9809 3187199 PK04_093126 OCCCOc1ccc(cc1)C2=N[C@@](Cc3ccccc3)([C@@H](O2)c4ccccc4CN=[N+]=[N-])C(=O)NCC(O)CO 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 G09 compound treatment 431850.0 -134000.0 -0.67 319700.0 -287000.0 -1.35 -1.4277 -0.9477 3068325 PK04_093127 OCCCOc1ccc(cc1)C2=N[C@](CC=C)([C@H](O2)c3ccccc3N=[N+]=[N-])C(=O)O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 G10 compound treatment 179170.0 -387000.0 -1.93 283680.0 -323000.0 -1.52 -2.4399 -0.9929 3187200 PK04_093128 COCCCNC(=O)[C@@]1(Cc2ccccc2)N=C(O[C@H]1c3ccccc3)c4ccc(OCCCO)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 G11 compound treatment 395700.0 -170000.0 -0.85 483760.0 -123000.0 -0.58 -1.0097 -0.9823 3187201 PK04_093129 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3N=[N+]=[N-])([C@H](O2)c4ccccc4N=[N+]=[N-])C(=O)O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 G12 compound treatment 105450.0 -460000.0 -2.3 158320.0 -448000.0 -2.11 -3.1172 -0.9991 3068327 PK04_093130 OCCCOc1ccc(cc1)C2=N[C@@](Cc3ccccc3)([C@@H](O2)c4ccccc4N=[N+]=[N-])C(=O)NCc5ccccc5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 G13 compound treatment 110340.0 -456000.0 -2.28 148050.0 -459000.0 -2.16 -3.1341 -0.9996 3187202 PK04_093131 COC(=O)[C@]1(Cc2ccccc2N=[N+]=[N-])N=C(O[C@@H]1c3ccccc3N=[N+]=[N-])c4ccc(OCCCO)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 G14 compound treatment 582690.0 16800.0 0.08 668560.0 61900.0 0.29 0.2653 0.8752 3187203 PK04_093132 CC(C)(C)OC(=O)CC[C@]1(N=C(O[C@@H]1c2ccccc2CN=[N+]=[N-])c3ccc(OCCCO)cc3)C(=O)NCCN4CCOCC4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 G15 compound treatment 614090.0 48200.0 0.24 478170.0 -128000.0 -0.6 -0.257 -0.3952 3068330 PK04_093133 COC(=O)[C@@]1(CC=C)COC(=N1)c2ccc(OCCCO)cc2 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 G16 compound treatment 300430.0 -265000.0 -1.33 203390.0 -403000.0 -1.9 -2.2787 -0.9847 3068332 PK04_093134 NC(=O)[C@]1(Cc2ccccc2CN=[N+]=[N-])N=C(O[C@@H]1c3ccccc3)c4ccc(OCCCO)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 G17 compound treatment 475010.0 -90900.0 -0.45 454490.0 -152000.0 -0.72 -0.827 -0.9759 3187278 PK04_093135 OCCCOc1ccc(cc1)C2=N[C@@](Cc3ccccc3CN=[N+]=[N-])([C@@H](O2)c4ccccc4CN=[N+]=[N-])C(=O)O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 G18 compound treatment 259940.0 -306000.0 -1.53 213010.0 -394000.0 -1.85 -2.3897 -0.9955 3187279 PK04_093136 COCCCNC(=O)[C@]1(Cc2ccccc2)N=C(O[C@@H]1c3ccccc3)c4ccc(OCCCO)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 G19 mock treatment 608190.0 42300.0 0.21 645040.0 38400.0 0.18 0.2771 0.997 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 G20 mock treatment 604570.0 38700.0 0.19 633870.0 27200.0 0.13 0.2272 0.9801 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 G21 compound treatment 556240.0 -9650.0 -0.05 596410.0 -10200.0 -0.05 -0.0681 -1.0 3187280 PK04_093137 OCCCOc1ccc(cc1)C2=N[C@](CCS(=O)(=O)c3ccccc3)([C@H](O2)c4ccccc4)C(=O)O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 G22 compound treatment 149000.0 -417000.0 -2.08 168110.0 -439000.0 -2.06 -2.9308 -1.0 3068361 PK04_093138 COCCCNC(=O)[C@]1(Cc2ccccc2N=[N+]=[N-])N=C(O[C@@H]1c3ccccc3)c4ccc(OCCCO)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 G23 compound treatment 402600.0 -163000.0 -0.82 300050.0 -307000.0 -1.44 -1.5964 -0.9636 3187281 PK04_093139 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3CN=[N+]=[N-])([C@H](O2)c4ccccc4)C(=O)O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 G24 compound treatment 192980.0 -373000.0 -1.86 200480.0 -406000.0 -1.91 -2.6678 -0.9999 3187282 PK04_093140 CN(C)C(=O)[C@@]1(Cc2ccccc2N=[N+]=[N-])N=C(O[C@H]1c3ccccc3CN=[N+]=[N-])c4ccc(OCCCO)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 H01 compound treatment 130200.0 -436000.0 -2.18 89890.0 -517000.0 -2.43 -3.2574 -0.9985 3068365 PK04_093141 OCCCOc1ccc(cc1)C2=N[C@@]3(CC=C)[C@@H](O2)c4ccccc4N(CCS(=O)(=O)c5ccccc5)C3=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 H02 compound treatment 144770.0 -421000.0 -2.1 185340.0 -421000.0 -1.98 -2.8885 -0.9996 3187283 PK04_093142 OCCCOc1ccc(cc1)C2=N[C@@](Cc3ccccc3)([C@@H](O2)c4ccccc4CN=[N+]=[N-])C(=O)NCc5ccccc5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 H03 mock treatment 310730.0 -255000.0 -1.27 633250.0 26600.0 0.13 -0.8126 -0.6346 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 H04 mock treatment 663790.0 97900.0 0.49 648200.0 41600.0 0.2 0.484 0.9191 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 H05 compound treatment 372680.0 -193000.0 -0.96 308130.0 -299000.0 -1.4 -1.6752 -0.9833 3068368 PK04_093143 OCCCOc1ccc(cc1)C2=N[C@]3(Cc4ccccc4)[C@H](O2)c5ccccc5CN(CCS(=O)(=O)c6ccccc6)C3=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 H06 compound treatment 530850.0 -35000.0 -0.18 545720.0 -60900.0 -0.29 -0.3263 -0.972 3187284 PK04_093144 CC(C)(C)OC(=O)CC[C@]1(N=C(O[C@@H]1c2ccccc2CN=[N+]=[N-])c3ccc(OCCCO)cc3)C(=O)N4CCOCC4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 H07 compound treatment 412030.0 -154000.0 -0.77 209700.0 -397000.0 -1.87 -1.8636 -0.923 3187285 PK04_093145 CC(C)(C)OC(=O)CC[C@@]12N=C(O[C@H]2c3ccccc3CN(CC=C)C1=O)c4ccc(OCCCO)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 H08 compound treatment 561800.0 -4090.0 -0.02 267060.0 -340000.0 -1.6 -1.1439 -0.7161 3068370 PK04_093146 CC(C)(C)OC(=O)CC[C@@]1(N=C(O[C@H]1c2ccccc2N=[N+]=[N-])c3ccc(OCCCO)cc3)C(=O)NCC(O)CO 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 H09 compound treatment 380250.0 -186000.0 -0.93 145680.0 -461000.0 -2.17 -2.1887 -0.9282 3187286 PK04_093147 OCCCOc1ccc(cc1)C2=N[C@@]3(Cc4ccccc4)[C@@H](O2)c5ccccc5N(CC=C)C3=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 H10 compound treatment 229760.0 -336000.0 -1.68 190690.0 -416000.0 -1.96 -2.5705 -0.9971 3187287 PK04_093148 CN(C)C(=O)[C@@]1(Cc2ccccc2)N=C(O[C@H]1c3ccccc3CN=[N+]=[N-])c4ccc(OCCCO)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 H11 compound treatment 349470.0 -216000.0 -1.08 217370.0 -389000.0 -1.83 -2.059 -0.9684 3068373 PK04_093149 OCCCOc1ccc(cc1)C2=N[C@]3(CCS(=O)(=O)c4ccccc4)[C@H](O2)c5ccccc5CN(CC=C)C3=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 H12 compound treatment 451780.0 -114000.0 -0.57 285500.0 -321000.0 -1.51 -1.4711 -0.9112 3187288 PK04_093150 OCCCOc1ccc(cc1)C2=N[C@](CC=C)(CO2)C(=O)NCc3ccccc3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 H13 compound treatment 271840.0 -294000.0 -1.47 202270.0 -404000.0 -1.9 -2.3834 -0.9918 3187289 PK04_093151 CC(C)(C)OC(=O)CC[C@@]12N=C(O[C@H]2c3ccccc3N(CC=C)C1=O)c4ccc(OCCCO)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 H14 compound treatment 131060.0 -435000.0 -2.17 162670.0 -444000.0 -2.09 -3.0123 -0.9998 3068375 PK04_093152 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3N=[N+]=[N-])([C@H](O2)c4ccccc4N=[N+]=[N-])C(=O)NCC(O)CO 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 H15 compound treatment 254030.0 -312000.0 -1.56 169920.0 -437000.0 -2.05 -2.5539 -0.9907 3187290 PK04_093153 OCCCOc1ccc(cc1)C2=N[C@]3(CC=C)[C@H](O2)c4ccccc4N(CC=C)C3=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 H16 compound treatment 477280.0 -88600.0 -0.44 300200.0 -306000.0 -1.44 -1.3321 -0.8835 3187291 PK04_093154 OCCCOc1ccc(cc1)C2=N[C@](CCS(=O)(=O)c3ccccc3)([C@H](O2)c4ccccc4CN=[N+]=[N-])C(=O)N5CCOCC5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 H17 compound treatment 585990.0 20100.0 0.1 420450.0 -186000.0 -0.88 -0.5483 -0.622 3068378 PK04_093155 OCCCOc1ccc(cc1)C2=N[C@@]3(CCS(=O)(=O)c4ccccc4)[C@@H](O2)c5ccccc5N(CCS(=O)(=O)c6ccccc6)C3=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 H18 compound treatment 650920.0 85000.0 0.42 689350.0 82700.0 0.39 0.5754 0.999 3187292 PK04_093156 OCCCOc1ccc(cc1)C2=N[C@](CCS(=O)(=O)c3ccccc3)(CO2)C(=O)NCCN4CCOCC4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 H19 mock treatment 604450.0 38600.0 0.19 595420.0 -11200.0 -0.05 0.0989 0.4952 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 H20 mock treatment 637920.0 72000.0 0.36 649690.0 43100.0 0.2 0.3976 0.963 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 H21 compound treatment 182400.0 -383000.0 -1.92 194970.0 -412000.0 -1.94 -2.7235 -1.0 3187293 PK04_093157 OCCCOc1ccc(cc1)C2=N[C@]3(Cc4ccccc4)[C@H](O2)c5ccccc5N(CCS(=O)(=O)c6ccccc6)C3=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 H22 compound treatment 258940.0 -307000.0 -1.53 234240.0 -372000.0 -1.75 -2.3226 -0.9978 3068380 PK04_093158 OCCCOc1ccc(cc1)C2=N[C@@](Cc3ccccc3)([C@@H](O2)c4ccccc4N=[N+]=[N-])C(=O)NCC(O)CO 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 H23 compound treatment 248550.0 -317000.0 -1.58 229810.0 -377000.0 -1.77 -2.374 -0.9984 3068402 PK04_093159 OCCCOc1ccc(cc1)C2=N[C@]3(CC=C)[C@H](O2)c4ccccc4CN(CCS(=O)(=O)c5ccccc5)C3=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 H24 compound treatment 180550.0 -385000.0 -1.92 224220.0 -382000.0 -1.8 -2.6328 -0.9994 3187294 PK04_093160 OCCCOc1ccc(cc1)C2=N[C@@](Cc3ccccc3)([C@@H](O2)c4ccccc4)C(=O)N5CCCCC5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 I01 compound treatment 468650.0 -97200.0 -0.49 426140.0 -180000.0 -0.85 -0.9437 -0.9649 3068406 PK04_093161 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3CN=[N+]=[N-])([C@H](O2)c4ccccc4CN=[N+]=[N-])C(=O)O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 I02 compound treatment 250470.0 -315000.0 -1.58 177920.0 -429000.0 -2.02 -2.5398 -0.9925 3187295 PK04_093162 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3)([C@H](O2)c4ccccc4N=[N+]=[N-])C(=O)NCC(O)CO 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 I03 compound treatment 412380.0 -154000.0 -0.77 269710.0 -337000.0 -1.58 -1.6627 -0.9445 3068409 PK04_093163 COC(=O)[C@@H]1N=C(O[C@@H]1c2ccccc2CN=[N+]=[N-])c3ccc(OCCCO)cc3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 I04 compound treatment 467120.0 -98800.0 -0.49 634880.0 28200.0 0.13 -0.2549 -0.4989 3187296 PK04_093164 CN(C)C(=O)[C@@]1(CCC(=O)OC(C)(C)C)COC(=N1)c2ccc(OCCCO)cc2 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 I05 mock treatment 563170.0 -2720.0 -0.01 711770.0 105000.0 0.49 0.3401 0.6874 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 I06 mock treatment 664450.0 98600.0 0.49 318180.0 -288000.0 -1.36 -0.6113 -0.4235 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 I07 compound treatment 141630.0 -424000.0 -2.12 369790.0 -237000.0 -1.11 -2.2861 -0.9549 3187297 PK04_093165 OCCCOc1ccc(cc1)C2=N[C@](CCS(=O)(=O)c3ccccc3)(CO2)C(=O)O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 I08 compound treatment 584450.0 18600.0 0.09 425140.0 -181000.0 -0.85 -0.5381 -0.6266 3068413 PK04_093166 CC(C)(C)OC(=O)CC[C@]1(N=C(O[C@@H]1c2ccccc2CN=[N+]=[N-])c3ccc(OCCCO)cc3)C(=O)N 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 I09 compound treatment 369830.0 -196000.0 -0.98 571410.0 -35200.0 -0.17 -0.8096 -0.8152 3187298 PK04_093167 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3N=[N+]=[N-])([C@H](O2)c4ccccc4CN=[N+]=[N-])C(=O)O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 I10 compound treatment 161190.0 -405000.0 -2.02 181460.0 -425000.0 -2.0 -2.8434 -1.0 3187366 PK04_093168 OCCCOc1ccc(cc1)C2=N[C@@](CCS(=O)(=O)c3ccccc3)([C@@H](O2)c4ccccc4)C(=O)N5CCOCC5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 I11 compound treatment 426240.0 -140000.0 -0.7 207370.0 -399000.0 -1.88 -1.8211 -0.9091 3068416 PK04_093169 CC(C)(C)OC(=O)CC[C@]1(N=C(O[C@@H]1c2ccccc2N=[N+]=[N-])c3ccc(OCCCO)cc3)C(=O)O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 I12 compound treatment 168340.0 -398000.0 -1.99 192270.0 -414000.0 -1.95 -2.7822 -1.0 3187367 PK04_093170 OCCCOc1ccc(cc1)C2=N[C@](CCS(=O)(=O)c3ccccc3)([C@H](O2)c4ccccc4N=[N+]=[N-])C(=O)N5CCOCC5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 I13 compound treatment 564930.0 -959.0 0.0 634040.0 27400.0 0.13 0.0878 0.6804 3068419 PK04_093171 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3CN=[N+]=[N-])(CO2)C(=O)O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 I14 compound treatment 381800.0 -184000.0 -0.92 289890.0 -317000.0 -1.49 -1.7036 -0.9731 3187368 PK04_093172 CN(C)C(=O)[C@@]1(CC=C)N=C(O[C@H]1c2ccccc2N=[N+]=[N-])c3ccc(OCCCO)cc3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 I15 compound treatment 581250.0 15400.0 0.08 619520.0 12900.0 0.06 0.0971 0.9932 3068421 PK04_093173 COC(=O)[C@@]1(Cc2ccccc2)COC(=N1)c3ccc(OCCCO)cc3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 I16 compound treatment 133810.0 -432000.0 -2.16 213120.0 -394000.0 -1.85 -2.8348 -0.9971 3187369 PK04_093174 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3CN=[N+]=[N-])([C@H](O2)c4ccccc4)C(=O)NCCN5CCOCC5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 I17 compound treatment 575530.0 9640.0 0.05 651480.0 44800.0 0.21 0.1832 0.8467 3068423 PK04_093175 CC(C)(C)OC(=O)CC[C@@]1(COC(=N1)c2ccc(OCCCO)cc2)C(=O)O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 I18 compound treatment 629060.0 63200.0 0.32 717870.0 111000.0 0.52 0.5931 0.9707 3187370 PK04_093176 CC(C)(C)OC(=O)CC[C@@]1(N=C(O[C@H]1c2ccccc2)c3ccc(OCCCO)cc3)C(=O)NCCN4CCOCC4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 I19 compound treatment 370470.0 -195000.0 -0.98 416040.0 -191000.0 -0.9 -1.3241 -0.9991 3187371 PK04_093177 COC(=O)[C@H]1N=C(O[C@H]1c2ccccc2)c3ccc(OCCCO)cc3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 I20 compound treatment 178100.0 -388000.0 -1.94 209320.0 -397000.0 -1.87 -2.691 -0.9998 3068425 PK04_093178 CC(C)(C)OC(=O)CC[C@@]1(N=C(O[C@H]1c2ccccc2N=[N+]=[N-])c3ccc(OCCCO)cc3)C(=O)N4CCCCC4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 I21 mock treatment 552020.0 -13900.0 -0.07 570300.0 -36300.0 -0.17 -0.1698 -0.9209 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 I22 mock treatment 557030.0 -8860.0 -0.04 621690.0 15100.0 0.07 0.0188 0.225 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 I23 compound treatment 349700.0 -216000.0 -1.08 523800.0 -82800.0 -0.39 -1.039 -0.9051 3187372 PK04_093179 OCCCOc1ccc(cc1)C2=N[C@@](CC=C)([C@@H](O2)c3ccccc3N=[N+]=[N-])C(=O)O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 I24 compound treatment 297990.0 -268000.0 -1.34 208220.0 -398000.0 -1.87 -2.2712 -0.9864 3068456 PK04_093180 OCCCOc1ccc(cc1)C2=N[C@@](Cc3ccccc3)([C@@H](O2)c4ccccc4)C(=O)NCCN5CCOCC5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 J01 compound treatment 72370.0 -494000.0 -2.46 129360.0 -477000.0 -2.24 -3.3303 -0.9989 3187373 PK04_093181 CC(C)(C)OC(=O)CC[C@]12N=C(O[C@@H]2c3ccccc3N(CC=C)C1=O)c4ccc(OCCCO)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 J02 compound treatment 193090.0 -373000.0 -1.86 190250.0 -416000.0 -1.96 -2.7015 -0.9997 3187374 PK04_093182 CN(C)C(=O)[C@]1(Cc2ccccc2CN=[N+]=[N-])N=C(O[C@@H]1c3ccccc3N=[N+]=[N-])c4ccc(OCCCO)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 J03 compound treatment 147480.0 -418000.0 -2.09 227960.0 -379000.0 -1.78 -2.7371 -0.9968 3068460 PK04_093183 OCCCOc1ccc(cc1)C2=N[C@@]3(CCS(=O)(=O)c4ccccc4)[C@@H](O2)c5ccccc5N(CC=C)C3=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 J04 compound treatment 560200.0 -5690.0 -0.03 192640.0 -414000.0 -1.95 -1.397 -0.7173 3187375 PK04_093184 COCCCNC(=O)[C@@]1(CC=C)COC(=N1)c2ccc(OCCCO)cc2 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 J05 mock treatment 499550.0 -66300.0 -0.33 289330.0 -317000.0 -1.49 -1.2896 -0.8435 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 J06 mock treatment 587570.0 21700.0 0.11 563900.0 -42700.0 -0.2 -0.0656 -0.2872 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 J07 compound treatment 149290.0 -417000.0 -2.08 261360.0 -345000.0 -1.62 -2.6197 -0.9925 3187376 PK04_093185 OCCCOc1ccc(cc1)C2=N[C@@]3(Cc4ccccc4CN(CCS(=O)(=O)c5ccccc5)C3=O)[C@@H](O2)c6ccccc6 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 J08 compound treatment 177730.0 -388000.0 -1.94 266150.0 -340000.0 -1.6 -2.5033 -0.9955 3068463 PK04_093186 OCCCOc1ccc(cc1)C2=N[C@@](Cc3ccccc3N=[N+]=[N-])([C@@H](O2)c4ccccc4CN=[N+]=[N-])C(=O)N5CCOCC5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 J09 compound treatment 388820.0 -177000.0 -0.88 257950.0 -349000.0 -1.64 -1.7851 -0.958 3187377 PK04_093187 OCCCOc1ccc(cc1)C2=N[C@@]3(CO2)Cc4ccccc4N(CCS(=O)(=O)c5ccccc5)C3=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 J10 compound treatment 395560.0 -170000.0 -0.85 532770.0 -73900.0 -0.35 -0.8472 -0.922 3068465 PK04_093188 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3)(CO2)C(=O)N4CCCCC4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 J11 compound treatment 201790.0 -364000.0 -1.82 263270.0 -343000.0 -1.62 -2.4279 -0.9982 3187378 PK04_093189 OCCCOc1ccc(cc1)C2=N[C@@]3(Cc4ccccc4CN(Cc5ccccc5)C3=O)[C@@H](O2)c6ccccc6 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 J12 compound treatment 526080.0 -39800.0 -0.2 589540.0 -17100.0 -0.08 -0.1974 -0.9206 3068467 PK04_093190 COCCCNC(=O)[C@@]1(CCS(=O)(=O)c2ccccc2)COC(=N1)c3ccc(OCCCO)cc3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 J13 compound treatment 172640.0 -393000.0 -1.96 157030.0 -450000.0 -2.11 -2.8842 -0.9993 3187379 PK04_093191 OCCCOc1ccc(cc1)C2=N[C@]3(Cc4ccccc4CN(Cc5ccccc5)C3=O)[C@H](O2)c6ccccc6 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 J14 compound treatment 129180.0 -437000.0 -2.18 123170.0 -483000.0 -2.27 -3.1503 -0.9998 3187380 PK04_093192 COCCCNC(=O)[C@]1(Cc2ccccc2N=[N+]=[N-])N=C(O[C@@H]1c3ccccc3N=[N+]=[N-])c4ccc(OCCCO)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 J15 compound treatment 561300.0 -4590.0 -0.02 286100.0 -321000.0 -1.51 -1.0823 -0.7178 3068470 PK04_093193 OCCCOc1ccc(cc1)C2=N[C@@]3(CCS(=O)(=O)c4ccccc4)[C@@H](O2)c5ccccc5N(Cc6ccccc6)C3=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 J16 compound treatment 379680.0 -186000.0 -0.93 420430.0 -186000.0 -0.88 -1.2769 -0.9996 3187381 PK04_093194 CC(C)(C)OC(=O)CC[C@]1(N=C(O[C@@H]1c2ccccc2N=[N+]=[N-])c3ccc(OCCCO)cc3)C(=O)NCCN4CCOCC4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 J17 compound treatment 413400.0 -152000.0 -0.76 633760.0 27100.0 0.13 -0.4483 -0.5806 3187382 PK04_093195 OCCCOc1ccc(cc1)C2=N[C@@]3(CCS(=O)(=O)c4ccccc4)[C@@H](O2)c5ccccc5CN(Cc6ccccc6)C3=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 J18 compound treatment 277920.0 -288000.0 -1.44 158830.0 -448000.0 -2.11 -2.5064 -0.9827 3068473 PK04_093196 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3)(CO2)C(=O)NCc4ccccc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 J19 compound treatment 478720.0 -87200.0 -0.44 410980.0 -196000.0 -0.92 -0.9586 -0.9416 3187383 PK04_093197 OCCCOc1ccc(cc1)C2=N[C@@]3(CCS(=O)(=O)c4ccccc4)[C@@H](O2)c5ccccc5CN(CCS(=O)(=O)c6ccccc6)C3=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 J20 compound treatment 209500.0 -356000.0 -1.78 237410.0 -369000.0 -1.74 -2.4867 -0.9999 3068475 PK04_093198 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3CN=[N+]=[N-])([C@H](O2)c4ccccc4)C(=O)NCC(O)CO 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 J21 mock treatment 566850.0 961.0 0.0 549200.0 -57400.0 -0.27 -0.1876 -0.6944 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 J22 mock treatment 590490.0 24600.0 0.12 499530.0 -107000.0 -0.5 -0.2693 -0.5194 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 J23 compound treatment 336740.0 -229000.0 -1.14 441280.0 -165000.0 -0.78 -1.3592 -0.9823 3187384 PK04_093199 OCCCOc1ccc(cc1)C2=N[C@]3(CCS(=O)(=O)c4ccccc4)[C@H](O2)c5ccccc5CN(CCS(=O)(=O)c6ccccc6)C3=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 J24 compound treatment 217080.0 -349000.0 -1.74 204870.0 -402000.0 -1.89 -2.5681 -0.9992 3068477 PK04_093200 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3CN=[N+]=[N-])([C@H](O2)c4ccccc4N=[N+]=[N-])C(=O)N5CCOCC5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 K01 compound treatment 542620.0 -23300.0 -0.12 273670.0 -333000.0 -1.57 -1.1896 -0.7575 3187385 PK04_093201 CC(C)(C)OC(=O)CC[C@@]1(N=C(O[C@H]1c2ccccc2)c3ccc(OCCCO)cc3)C(=O)O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 K02 compound treatment 199710.0 -366000.0 -1.83 232220.0 -374000.0 -1.76 -2.5385 -0.9998 3187386 PK04_093202 OCCCOc1ccc(cc1)C2=N[C@](CCS(=O)(=O)c3ccccc3)([C@H](O2)c4ccccc4)C(=O)NCc5ccccc5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 K03 compound treatment 510880.0 -55000.0 -0.27 231610.0 -375000.0 -1.76 -1.4416 -0.8075 3187447 PK04_093203 OCCCOc1ccc(cc1)C2=N[C@@](CCS(=O)(=O)c3ccccc3)([C@@H](O2)c4ccccc4N=[N+]=[N-])C(=O)O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 K04 compound treatment 182360.0 -384000.0 -1.92 123940.0 -483000.0 -2.27 -2.9599 -0.9964 3068500 PK04_093204 CC(C)(C)OC(=O)CC[C@]1(N=C(O[C@@H]1c2ccccc2CN=[N+]=[N-])c3ccc(OCCCO)cc3)C(=O)N4CCCCC4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 K05 compound treatment 164930.0 -401000.0 -2.0 166240.0 -440000.0 -2.07 -2.8808 -0.9999 3187448 PK04_093205 COC(=O)[C@@]1(CCC(=O)OC(C)(C)C)N=C(O[C@H]1c2ccccc2CN=[N+]=[N-])c3ccc(OCCCO)cc3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 K06 compound treatment 410890.0 -155000.0 -0.77 336120.0 -271000.0 -1.27 -1.4471 -0.9716 3187449 PK04_093206 CN(C)C(=O)[C@@]1(Cc2ccccc2CN=[N+]=[N-])N=C(O[C@H]1c3ccccc3)c4ccc(OCCCO)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 K07 mock treatment 648640.0 82800.0 0.41 542780.0 -63900.0 -0.3 0.0799 0.1563 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 K08 mock treatment 619380.0 53500.0 0.27 672570.0 65900.0 0.31 0.4082 0.9972 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 K09 compound treatment 505160.0 -60700.0 -0.3 680210.0 73600.0 0.35 0.0302 0.0657 3068503 PK04_093207 CC(C)(C)OC(=O)CC[C@@]1(N=C(O[C@H]1c2ccccc2N=[N+]=[N-])c3ccc(OCCCO)cc3)C(=O)O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 K10 compound treatment 487870.0 -78000.0 -0.39 395440.0 -211000.0 -0.99 -0.978 -0.9165 3187450 PK04_093208 OCCCOc1ccc(cc1)C2=N[C@](CCS(=O)(=O)c3ccccc3)(CO2)C(=O)N4CCCCC4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 K11 compound treatment 291050.0 -275000.0 -1.37 307640.0 -299000.0 -1.41 -1.9651 -0.9999 3068506 PK04_093209 COC(=O)[C@@]1(CCS(=O)(=O)c2ccccc2)N=C(O[C@H]1c3ccccc3CN=[N+]=[N-])c4ccc(OCCCO)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 K12 compound treatment 192060.0 -374000.0 -1.87 256110.0 -351000.0 -1.65 -2.4861 -0.9981 3187451 PK04_093210 CN(C)C(=O)[C@]1(CC=C)N=C(O[C@@H]1c2ccccc2N=[N+]=[N-])c3ccc(OCCCO)cc3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 K13 compound treatment 533800.0 -32100.0 -0.16 429980.0 -177000.0 -0.83 -0.7009 -0.8282 3187452 PK04_093211 OCCCOc1ccc(cc1)C2=N[C@](CCS(=O)(=O)c3ccccc3)([C@H](O2)c4ccccc4CN=[N+]=[N-])C(=O)O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 K14 compound treatment 401400.0 -164000.0 -0.82 423170.0 -183000.0 -0.86 -1.1911 -0.9997 3068509 PK04_093212 OCCCOc1ccc(cc1)C2=N[C@@](CCS(=O)(=O)c3ccccc3)([C@@H](O2)c4ccccc4CN=[N+]=[N-])C(=O)N5CCCCC5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 K15 mock treatment 625870.0 60000.0 0.3 542420.0 -64200.0 -0.3 -0.0017 -0.0041 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 K16 mock treatment 691530.0 126000.0 0.63 734240.0 128000.0 0.6 0.8681 0.9998 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 K17 compound treatment 662510.0 96600.0 0.48 732340.0 126000.0 0.59 0.7593 0.9949 3187453 PK04_093213 OCCCOc1ccc(cc1)C2=N[C@](CC=C)(CO2)C(=O)O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 K18 compound treatment 465040.0 -101000.0 -0.5 489050.0 -118000.0 -0.55 -0.7472 -0.9989 3187454 PK04_093214 OCCCOc1ccc(cc1)C2=N[C@](CCS(=O)(=O)c3ccccc3)([C@H](O2)c4ccccc4CN=[N+]=[N-])C(=O)NCCN5CCOCC5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 K19 compound treatment 172030.0 -394000.0 -1.97 206400.0 -400000.0 -1.88 -2.7221 -0.9998 3068511 PK04_093215 COC(=O)[C@]1(Cc2ccccc2CN=[N+]=[N-])N=C(O[C@@H]1c3ccccc3N=[N+]=[N-])c4ccc(OCCCO)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 K20 compound treatment 219080.0 -347000.0 -1.73 229040.0 -378000.0 -1.78 -2.4807 -0.9999 3187455 PK04_093216 OCCCOc1ccc(cc1)C2=N[C@@](Cc3ccccc3CN=[N+]=[N-])([C@@H](O2)c4ccccc4N=[N+]=[N-])C(=O)NCCN5CCOCC5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 K21 compound treatment 590790.0 24900.0 0.12 694490.0 87900.0 0.41 0.3801 0.8809 3068513 PK04_093217 COC(=O)[C@@]1(CCS(=O)(=O)c2ccccc2)COC(=N1)c3ccc(OCCCO)cc3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 K22 compound treatment 138100.0 -428000.0 -2.14 176190.0 -430000.0 -2.02 -2.9425 -0.9996 3187456 PK04_093218 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3)([C@H](O2)c4ccccc4N=[N+]=[N-])C(=O)NCCN5CCOCC5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 K23 mock treatment 534400.0 -31500.0 -0.16 644000.0 37400.0 0.18 0.0131 0.0554 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 K24 mock treatment 443930.0 -122000.0 -0.61 626130.0 19500.0 0.09 -0.3659 -0.594 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 L01 compound treatment 116540.0 -449000.0 -2.24 121440.0 -485000.0 -2.28 -3.2007 -1.0 3187457 PK04_093219 OCCCOc1ccc(cc1)C2=N[C@]3(CC=C)[C@H](O2)c4ccccc4N(CCS(=O)(=O)c5ccccc5)C3=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 L02 compound treatment 275740.0 -290000.0 -1.45 197370.0 -409000.0 -1.93 -2.3859 -0.9902 3068516 PK04_093220 OCCCOc1ccc(cc1)C2=N[C@@](Cc3ccccc3N=[N+]=[N-])([C@@H](O2)c4ccccc4CN=[N+]=[N-])C(=O)NCc5ccccc5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 L03 compound treatment 163040.0 -403000.0 -2.01 163900.0 -443000.0 -2.08 -2.8953 -0.9999 3187458 PK04_093221 CC(C)(C)OC(=O)CC[C@@]12N=C(O[C@H]2c3ccccc3CN(CCS(=O)(=O)c4ccccc4)C1=O)c5ccc(OCCCO)cc5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 L04 compound treatment 246980.0 -319000.0 -1.59 172900.0 -434000.0 -2.04 -2.5689 -0.9925 3187459 PK04_093222 OCCCOc1ccc(cc1)C2=N[C@@](CCS(=O)(=O)c3ccccc3)([C@@H](O2)c4ccccc4N=[N+]=[N-])C(=O)NCc5ccccc5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 L05 compound treatment 146930.0 -419000.0 -2.09 161150.0 -445000.0 -2.1 -2.9613 -1.0 3068518 PK04_093223 OCCCOc1ccc(cc1)C2=N[C@]3(Cc4ccccc4N(CCS(=O)(=O)c5ccccc5)C3=O)[C@H](O2)c6ccccc6 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 L06 compound treatment 149190.0 -417000.0 -2.08 178510.0 -428000.0 -2.01 -2.8956 -0.9999 3187460 PK04_093224 OCCCOc1ccc(cc1)C2=N[C@@](Cc3ccccc3N=[N+]=[N-])([C@@H](O2)c4ccccc4CN=[N+]=[N-])C(=O)NCC(O)CO 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 L07 mock treatment 536640.0 -29200.0 -0.15 520480.0 -86200.0 -0.41 -0.3898 -0.905 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 L08 mock treatment 603240.0 37400.0 0.19 623870.0 17200.0 0.08 0.1892 0.9303 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 L09 compound treatment 269820.0 -296000.0 -1.48 545920.0 -60700.0 -0.29 -1.2476 -0.8284 3068520 PK04_093225 CC(C)(C)OC(=O)CC[C@]12N=C(O[C@@H]2c3ccccc3CN(CC=C)C1=O)c4ccc(OCCCO)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 L10 compound treatment 550960.0 -14900.0 -0.07 593230.0 -13400.0 -0.06 -0.0973 -0.9965 3187461 PK04_093226 CC(C)(C)OC(=O)CC[C@@]1(COC(=N1)c2ccc(OCCCO)cc2)C(=O)N 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 L11 compound treatment 224830.0 -341000.0 -1.7 186210.0 -420000.0 -1.98 -2.6028 -0.9972 3187462 PK04_093227 OCCCOc1ccc(cc1)C2=N[C@@]3(CC=C)[C@@H](O2)c4ccccc4N(Cc5ccccc5)C3=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 L12 compound treatment 276600.0 -289000.0 -1.44 289170.0 -317000.0 -1.49 -2.0776 -0.9999 3187463 PK04_093228 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3CN=[N+]=[N-])(CO2)C(=O)NCC(O)CO 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 L13 compound treatment 225860.0 -340000.0 -1.7 225440.0 -381000.0 -1.79 -2.4687 -0.9996 3068543 PK04_093229 OCCCOc1ccc(cc1)C2=N[C@]3(Cc4ccccc4N(Cc5ccccc5)C3=O)[C@H](O2)c6ccccc6 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 L14 compound treatment 236690.0 -329000.0 -1.64 185770.0 -421000.0 -1.98 -2.5624 -0.9957 3187464 PK04_093230 OCCCOc1ccc(cc1)C2=N[C@@](Cc3ccccc3N=[N+]=[N-])([C@@H](O2)c4ccccc4N=[N+]=[N-])C(=O)NCc5ccccc5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 L15 mock treatment 593490.0 27600.0 0.14 643460.0 36800.0 0.17 0.22 0.9936 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 L16 mock treatment 645760.0 79900.0 0.4 713450.0 107000.0 0.5 0.6373 0.9935 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 L17 compound treatment 414940.0 -151000.0 -0.75 385390.0 -221000.0 -1.04 -1.269 -0.9875 3068545 PK04_093231 OCCCOc1ccc(cc1)C2=N[C@@]3(CC=C)[C@@H](O2)c4ccccc4CN(CCS(=O)(=O)c5ccccc5)C3=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 L18 compound treatment 272870.0 -293000.0 -1.46 190450.0 -416000.0 -1.96 -2.4191 -0.9897 3187465 PK04_093232 OCCCOc1ccc(cc1)C2=N[C@@](Cc3ccccc3N=[N+]=[N-])([C@@H](O2)c4ccccc4N=[N+]=[N-])C(=O)N5CCCCC5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 L19 compound treatment 451150.0 -115000.0 -0.57 429870.0 -177000.0 -0.83 -0.9931 -0.9835 3187466 PK04_093233 OCCCOc1ccc(cc1)C2=N[C@@]3(CCS(=O)(=O)c4ccccc4)[C@@H](O2)c5ccccc5CN(CC=C)C3=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 L20 compound treatment 464000.0 -102000.0 -0.51 357610.0 -249000.0 -1.17 -1.1881 -0.9303 3068547 PK04_093234 NC(=O)[C@@]1(Cc2ccccc2)N=C(O[C@H]1c3ccccc3)c4ccc(OCCCO)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 L21 compound treatment 441480.0 -124000.0 -0.62 305230.0 -301000.0 -1.42 -1.4418 -0.9315 3187467 PK04_093235 OCCCOc1ccc(cc1)C2=N[C@@]3(CC=C)[C@@H](O2)c4ccccc4CN(CC=C)C3=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 L22 compound treatment 172690.0 -393000.0 -1.96 270180.0 -336000.0 -1.58 -2.5077 -0.9943 3068549 PK04_093236 OCCCOc1ccc(cc1)C2=N[C@@](Cc3ccccc3CN=[N+]=[N-])([C@@H](O2)c4ccccc4CN=[N+]=[N-])C(=O)N5CCOCC5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 L23 mock treatment 521790.0 -44100.0 -0.22 483690.0 -123000.0 -0.58 -0.5647 -0.9125 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 L24 mock treatment 451680.0 -114000.0 -0.57 625160.0 18500.0 0.09 -0.3417 -0.5922 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 M01 compound treatment 100440.0 -465000.0 -2.32 174450.0 -432000.0 -2.03 -3.0812 -0.9978 3187528 PK04_093237 COC(=O)[C@]1(CCS(=O)(=O)c2ccccc2)N=C(O[C@@H]1c3ccccc3)c4ccc(OCCCO)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 M02 compound treatment 163080.0 -403000.0 -2.01 173280.0 -433000.0 -2.04 -2.8639 -1.0 3187529 PK04_093238 OCCCOc1ccc(cc1)C2=N[C@@](CCS(=O)(=O)c3ccccc3)([C@@H](O2)c4ccccc4)C(=O)NCc5ccccc5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 M03 compound treatment 496850.0 -69000.0 -0.34 573800.0 -32800.0 -0.15 -0.353 -0.9344 3068551 PK04_093239 OCCCOc1ccc(cc1)C2=N[C@@](Cc3ccccc3)([C@@H](O2)c4ccccc4)C(=O)O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 M04 compound treatment 450210.0 -116000.0 -0.58 336480.0 -270000.0 -1.27 -1.3071 -0.9364 3187530 PK04_093240 CC(C)(C)OC(=O)CC[C@]1(N=C(O[C@@H]1c2ccccc2N=[N+]=[N-])c3ccc(OCCCO)cc3)C(=O)N4CCOCC4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 M05 compound treatment 559410.0 -6480.0 -0.03 557850.0 -48800.0 -0.23 -0.1851 -0.7989 3068553 PK04_093241 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3)([C@H](O2)c4ccccc4)C(=O)O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 M06 compound treatment 175680.0 -390000.0 -1.95 274350.0 -332000.0 -1.56 -2.4833 -0.994 3187531 PK04_093242 COCCCNC(=O)[C@@]1(Cc2ccccc2N=[N+]=[N-])COC(=N1)c3ccc(OCCCO)cc3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 M07 compound treatment 492100.0 -73800.0 -0.37 462400.0 -144000.0 -0.68 -0.7403 -0.9589 3187532 PK04_093243 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3)([C@H](O2)c4ccccc4CN=[N+]=[N-])C(=O)O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 M08 compound treatment 157860.0 -408000.0 -2.04 230950.0 -376000.0 -1.77 -2.6905 -0.9975 3068555 PK04_093244 OCCCOc1ccc(cc1)C2=N[C@@](Cc3ccccc3N=[N+]=[N-])([C@@H](O2)c4ccccc4CN=[N+]=[N-])C(=O)N5CCCCC5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 M09 mock treatment 586330.0 20400.0 0.1 668980.0 62300.0 0.29 0.2795 0.9003 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 M10 mock treatment 610830.0 44900.0 0.22 658110.0 51500.0 0.24 0.3299 0.9993 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 M11 compound treatment 546400.0 -19500.0 -0.1 610050.0 3410.0 0.02 -0.0575 -0.5826 3187533 PK04_093245 OCCCOc1ccc(cc1)C2=N[C@@](CC=C)([C@@H](O2)c3ccccc3CN=[N+]=[N-])C(=O)O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 M12 compound treatment 194430.0 -371000.0 -1.86 225300.0 -381000.0 -1.79 -2.5802 -0.9999 3187534 PK04_093246 COCCCNC(=O)[C@]1(Cc2ccccc2CN=[N+]=[N-])N=C(O[C@@H]1c3ccccc3N=[N+]=[N-])c4ccc(OCCCO)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 M13 mock treatment 594940.0 29100.0 0.15 632450.0 25800.0 0.12 0.1885 0.9961 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 M14 mock treatment 635380.0 69500.0 0.35 716130.0 109000.0 0.52 0.6096 0.9815 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 M15 compound treatment 419040.0 -147000.0 -0.73 357510.0 -249000.0 -1.17 -1.3472 -0.9745 3068558 PK04_093247 OCCCOc1ccc(cc1)C2=N[C@@](Cc3ccccc3N=[N+]=[N-])([C@@H](O2)c4ccccc4)C(=O)O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 M16 compound treatment 614460.0 48600.0 0.24 700670.0 94000.0 0.44 0.4843 0.96 3187535 PK04_093248 CC(C)(C)OC(=O)CC[C@]1(N=C(O[C@@H]1c2ccccc2)c3ccc(OCCCO)cc3)C(=O)NCC(O)CO 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 M17 compound treatment 592510.0 26600.0 0.13 613050.0 6410.0 0.03 0.1154 0.8461 3068560 PK04_093249 OCCCOc1ccc(cc1)C2=N[C@@](CCS(=O)(=O)c3ccccc3)([C@@H](O2)c4ccccc4CN=[N+]=[N-])C(=O)O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 M18 compound treatment 202580.0 -363000.0 -1.81 216900.0 -390000.0 -1.83 -2.5793 -1.0 3187536 PK04_093250 OCCCOc1ccc(cc1)C2=N[C@@](CCS(=O)(=O)c3ccccc3)([C@@H](O2)c4ccccc4N=[N+]=[N-])C(=O)N5CCOCC5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 M19 compound treatment 555050.0 -10800.0 -0.05 588160.0 -18500.0 -0.09 -0.0997 -0.9741 3187537 PK04_093251 OCCCOc1ccc(cc1)C2=N[C@@](Cc3ccccc3)([C@@H](O2)c4ccccc4CN=[N+]=[N-])C(=O)O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 M20 compound treatment 568210.0 2320.0 0.01 644640.0 38000.0 0.18 0.1346 0.7514 3068562 PK04_093252 CC(C)(C)OC(=O)CC[C@@]1(COC(=N1)c2ccc(OCCCO)cc2)C(=O)N3CCOCC3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 M21 compound treatment 544860.0 -21000.0 -0.11 586990.0 -19600.0 -0.09 -0.1396 -0.998 3068586 PK04_093253 CC(C)(C)OC(=O)CC[C@]1(N=C(O[C@@H]1c2ccccc2CN=[N+]=[N-])c3ccc(OCCCO)cc3)C(=O)O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 M22 compound treatment 367940.0 -198000.0 -0.99 304220.0 -302000.0 -1.42 -1.7049 -0.9842 3187538 PK04_093254 NC(=O)[C@]1(Cc2ccccc2)N=C(O[C@@H]1c3ccccc3CN=[N+]=[N-])c4ccc(OCCCO)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 M23 compound treatment 173280.0 -393000.0 -1.96 77720.0 -529000.0 -2.49 -3.1457 -0.9931 3068589 PK04_093255 COC(=O)[C@]1(Cc2ccccc2N=[N+]=[N-])N=C(O[C@@H]1c3ccccc3)c4ccc(OCCCO)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 M24 compound treatment 104320.0 -462000.0 -2.31 160720.0 -446000.0 -2.1 -3.1132 -0.9989 3187539 PK04_093256 NC(=O)[C@]1(Cc2ccccc2)N=C(O[C@@H]1c3ccccc3N=[N+]=[N-])c4ccc(OCCCO)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 N01 compound treatment 157080.0 -409000.0 -2.04 159770.0 -447000.0 -2.1 -2.93 -0.9999 3187540 PK04_093257 CC(C)(C)OC(=O)CC[C@]12N=C(O[C@@H]2c3ccccc3N(CCS(=O)(=O)c4ccccc4)C1=O)c5ccc(OCCCO)cc5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 N02 compound treatment 203250.0 -363000.0 -1.81 147040.0 -460000.0 -2.16 -2.8093 -0.9961 3187541 PK04_093258 CN(C)C(=O)[C@@]1(Cc2ccccc2CN=[N+]=[N-])COC(=N1)c3ccc(OCCCO)cc3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 N03 compound treatment 72430.0 -493000.0 -2.46 71390.0 -535000.0 -2.52 -3.5229 -0.9999 3068594 PK04_093259 OCCCOc1ccc(cc1)C2=N[C@@]3(Cc4ccccc4CN(CC=C)C3=O)[C@@H](O2)c5ccccc5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 N04 compound treatment 494750.0 -71100.0 -0.36 586940.0 -19700.0 -0.09 -0.3167 -0.8626 3187542 PK04_093260 COCCCNC(=O)[C@@]1(CCC(=O)OC(C)(C)C)N=C(O[C@H]1c2ccccc2)c3ccc(OCCCO)cc3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 N05 compound treatment 372610.0 -193000.0 -0.97 158200.0 -448000.0 -2.11 -2.1741 -0.9372 3068597 PK04_093261 OCCCOc1ccc(cc1)C2=N[C@]3(CC=C)[C@H](O2)c4ccccc4CN(CC=C)C3=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 N06 compound treatment 426880.0 -139000.0 -0.69 210610.0 -396000.0 -1.86 -1.8081 -0.9095 3187543 PK04_093262 NC(=O)[C@@]1(CCS(=O)(=O)c2ccccc2)N=C(O[C@H]1c3ccccc3CN=[N+]=[N-])c4ccc(OCCCO)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 N07 compound treatment 91840.0 -474000.0 -2.37 164160.0 -442000.0 -2.08 -3.1458 -0.9979 3187544 PK04_093263 OCCCOc1ccc(cc1)C2=N[C@]3(Cc4ccccc4N(CC=C)C3=O)[C@H](O2)c5ccccc5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 N08 compound treatment 88320.0 -478000.0 -2.39 99040.0 -508000.0 -2.39 -3.3749 -1.0 3068600 PK04_093264 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3)([C@H](O2)c4ccccc4N=[N+]=[N-])C(=O)N5CCCCC5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 N09 mock treatment 324250.0 -242000.0 -1.21 446800.0 -160000.0 -0.75 -1.385 -0.9741 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 N10 mock treatment 595100.0 29200.0 0.15 593150.0 -13500.0 -0.06 0.0583 0.3665 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 N11 compound treatment 51370.0 -515000.0 -2.57 75790.0 -531000.0 -2.5 -3.5827 -0.9999 3187545 PK04_093265 OCCCOc1ccc(cc1)C2=N[C@@]3(CO2)Cc4ccccc4CN(CCS(=O)(=O)c5ccccc5)C3=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 N12 compound treatment 292230.0 -274000.0 -1.37 289390.0 -317000.0 -1.49 -2.0216 -0.999 3187546 PK04_093266 COCCCNC(=O)[C@]1(CCS(=O)(=O)c2ccccc2)N=C(O[C@@H]1c3ccccc3CN=[N+]=[N-])c4ccc(OCCCO)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 N13 mock treatment 579840.0 14000.0 0.07 705230.0 98600.0 0.46 0.3772 0.8043 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 N14 mock treatment 606130.0 40200.0 0.2 592010.0 -14600.0 -0.07 0.0935 0.44 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 N15 compound treatment 198260.0 -368000.0 -1.84 157500.0 -449000.0 -2.11 -2.7922 -0.9976 3068603 PK04_093267 CC(C)(C)OC(=O)CC[C@@]12N=C(O[C@H]2c3ccccc3N(CCS(=O)(=O)c4ccccc4)C1=O)c5ccc(OCCCO)cc5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 N16 compound treatment 445840.0 -120000.0 -0.6 540290.0 -66300.0 -0.31 -0.6446 -0.9537 3187547 PK04_093268 OCCCOc1ccc(cc1)C2=N[C@@](CCS(=O)(=O)c3ccccc3)([C@@H](O2)c4ccccc4CN=[N+]=[N-])C(=O)NCCN5CCOCC5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 N17 compound treatment 195680.0 -370000.0 -1.85 133040.0 -474000.0 -2.23 -2.8826 -0.9957 3068605 PK04_093269 OCCCOc1ccc(cc1)C2=N[C@]3(Cc4ccccc4)[C@H](O2)c5ccccc5N(CC=C)C3=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 N18 compound treatment 169450.0 -396000.0 -1.98 175600.0 -431000.0 -2.03 -2.8337 -0.9999 3187548 PK04_093270 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3N=[N+]=[N-])([C@H](O2)c4ccccc4CN=[N+]=[N-])C(=O)N5CCCCC5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 N19 compound treatment 416690.0 -149000.0 -0.75 244320.0 -362000.0 -1.7 -1.732 -0.9312 3068607 PK04_093271 OCCCOc1ccc(cc1)C2=N[C@@]3(CO2)Cc4ccccc4CN(CC=C)C3=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 N20 compound treatment 272990.0 -293000.0 -1.46 310460.0 -296000.0 -1.39 -2.0195 -0.9997 3186297 PK04_093272 NC(=O)[C@@]1(CC=C)N=C(O[C@H]1c2ccccc2N=[N+]=[N-])c3ccc(OCCCO)cc3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 N21 compound treatment 292720.0 -273000.0 -1.36 184090.0 -423000.0 -1.99 -2.3701 -0.9832 3186298 PK04_093273 OCCCOc1ccc(cc1)C2=N[C@@]3(Cc4ccccc4N(CC=C)C3=O)[C@@H](O2)c5ccccc5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 N22 compound treatment 342200.0 -224000.0 -1.12 391120.0 -216000.0 -1.01 -1.5068 -0.9988 3068610 PK04_093274 CC(C)(C)OC(=O)CC[C@]1(N=C(O[C@@H]1c2ccccc2)c3ccc(OCCCO)cc3)C(=O)NCCN4CCOCC4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 N23 compound treatment 88380.0 -478000.0 -2.38 144400.0 -462000.0 -2.17 -3.2238 -0.9989 3068635 PK04_093275 CC(=O)N1Cc2ccccc2C[C@]3(N=C(O[C@@H]3c4ccccc4)c5ccc(OCCCO)cc5)C1=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 N24 compound treatment 133280.0 -433000.0 -2.16 182420.0 -424000.0 -2.0 -2.9388 -0.9992 3186299 PK04_093276 COCCCNC(=O)[C@@]1(Cc2ccccc2CN=[N+]=[N-])COC(=N1)c3ccc(OCCCO)cc3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 O01 compound treatment 75550.0 -490000.0 -2.45 103680.0 -503000.0 -2.37 -3.4045 -0.9999 3068638 PK04_093277 COC(=O)[C@]1(CC=C)N=C(O[C@@H]1c2ccccc2CN=[N+]=[N-])c3ccc(OCCCO)cc3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 O02 compound treatment 157350.0 -409000.0 -2.04 113350.0 -493000.0 -2.32 -3.0835 -0.9979 3186300 PK04_093278 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3N=[N+]=[N-])([C@H](O2)c4ccccc4)C(=O)NCCN5CCOCC5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 O03 compound treatment 67410.0 -498000.0 -2.49 104590.0 -502000.0 -2.36 -3.4302 -0.9997 3068640 PK04_093279 COC(=O)[C@@]1(Cc2ccccc2)N=C(O[C@H]1c3ccccc3CN=[N+]=[N-])c4ccc(OCCCO)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 O04 compound treatment 520910.0 -45000.0 -0.22 554580.0 -52100.0 -0.24 -0.332 -0.9991 3186301 PK04_093280 CC(C)(C)OC(=O)CC[C@]1(N=C(O[C@@H]1c2ccccc2N=[N+]=[N-])c3ccc(OCCCO)cc3)C(=O)NCC(O)CO 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 O05 compound treatment 437560.0 -128000.0 -0.64 379360.0 -227000.0 -1.07 -1.2091 -0.9701 3068642 PK04_093281 OCCCOc1ccc(cc1)C2=N[C@](CC=C)([C@H](O2)c3ccccc3)C(=O)O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 O06 compound treatment 482340.0 -83500.0 -0.42 541550.0 -65100.0 -0.31 -0.5115 -0.9884 3186302 PK04_093282 COCCCNC(=O)[C@@]1(Cc2ccccc2)COC(=N1)c3ccc(OCCCO)cc3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 O07 compound treatment 546080.0 -19800.0 -0.1 532800.0 -73800.0 -0.35 -0.3155 -0.8738 3186303 PK04_093283 CC(C)(C)OC(=O)CC[C@@]1(N=C(O[C@H]1c2ccccc2CN=[N+]=[N-])c3ccc(OCCCO)cc3)C(=O)O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 O08 compound treatment 120260.0 -446000.0 -2.23 150500.0 -456000.0 -2.15 -3.0909 -0.9998 3068645 PK04_093284 CC(C)(C)OC(=O)CC[C@]1(N=C(O[C@@H]1c2ccccc2N=[N+]=[N-])c3ccc(OCCCO)cc3)C(=O)N4CCCCC4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 O09 compound treatment 46290.0 -520000.0 -2.6 62830.0 -544000.0 -2.56 -3.6437 -1.0 3186304 PK04_093285 COC(=O)[C@@]1(Cc2ccccc2N=[N+]=[N-])N=C(O[C@H]1c3ccccc3CN=[N+]=[N-])c4ccc(OCCCO)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 O10 compound treatment 203920.0 -362000.0 -1.81 164000.0 -443000.0 -2.08 -2.7505 -0.9975 3186305 PK04_093286 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3CN=[N+]=[N-])([C@H](O2)c4ccccc4CN=[N+]=[N-])C(=O)N5CCOCC5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 O11 mock treatment 574020.0 8130.0 0.04 646820.0 40200.0 0.19 0.1624 0.8399 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 O12 mock treatment 604930.0 39000.0 0.19 631680.0 25000.0 0.12 0.2212 0.9709 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 O13 compound treatment 274960.0 -291000.0 -1.45 407080.0 -200000.0 -0.94 -1.6912 -0.9776 3068648 PK04_093287 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3CN=[N+]=[N-])([C@H](O2)c4ccccc4N=[N+]=[N-])C(=O)O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 O14 compound treatment 438880.0 -127000.0 -0.63 508570.0 -98100.0 -0.46 -0.7747 -0.9878 3186306 PK04_093288 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3CN=[N+]=[N-])(CO2)C(=O)NCCN4CCOCC4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 O15 compound treatment 506420.0 -59500.0 -0.3 284000.0 -323000.0 -1.52 -1.2831 -0.8298 3068650 PK04_093289 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3)([C@H](O2)c4ccccc4N=[N+]=[N-])C(=O)O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 O16 compound treatment 126590.0 -439000.0 -2.19 191250.0 -415000.0 -1.95 -2.933 -0.9983 3186307 PK04_093290 CN(C)C(=O)[C@]1(CCS(=O)(=O)c2ccccc2)N=C(O[C@@H]1c3ccccc3N=[N+]=[N-])c4ccc(OCCCO)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 O17 compound treatment 196390.0 -369000.0 -1.85 300200.0 -306000.0 -1.44 -2.3241 -0.9925 3186308 PK04_093291 COC(=O)[C@@]1(Cc2ccccc2)N=C(O[C@H]1c3ccccc3N=[N+]=[N-])c4ccc(OCCCO)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 O18 compound treatment 259310.0 -307000.0 -1.53 251790.0 -355000.0 -1.67 -2.2629 -0.9991 3068652 PK04_093292 COCCCNC(=O)[C@]1(CCS(=O)(=O)c2ccccc2)N=C(O[C@@H]1c3ccccc3)c4ccc(OCCCO)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 O19 compound treatment 202240.0 -364000.0 -1.82 181490.0 -425000.0 -2.0 -2.6983 -0.9988 3186309 PK04_093293 COC(=O)[C@]1(Cc2ccccc2CN=[N+]=[N-])N=C(O[C@@H]1c3ccccc3CN=[N+]=[N-])c4ccc(OCCCO)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 O20 compound treatment 333050.0 -233000.0 -1.16 306330.0 -300000.0 -1.41 -1.8211 -0.9953 3068654 PK04_093294 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3CN=[N+]=[N-])(CO2)C(=O)N4CCOCC4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 O21 compound treatment 133940.0 -432000.0 -2.16 105030.0 -502000.0 -2.36 -3.1938 -0.999 3186310 PK04_093295 COC(=O)[C@@]1(Cc2ccccc2N=[N+]=[N-])N=C(O[C@H]1c3ccccc3N=[N+]=[N-])c4ccc(OCCCO)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 O22 compound treatment 214180.0 -352000.0 -1.76 153010.0 -454000.0 -2.13 -2.7509 -0.9953 3186311 PK04_093296 NC(=O)[C@]1(CC=C)N=C(O[C@@H]1c2ccccc2)c3ccc(OCCCO)cc3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 O23 compound treatment 153790.0 -412000.0 -2.06 189400.0 -417000.0 -1.96 -2.8431 -0.9997 3068656 PK04_093297 COC(=O)[C@@H]1N=C(O[C@@H]1c2ccccc2N=[N+]=[N-])c3ccc(OCCCO)cc3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 O24 compound treatment 173090.0 -393000.0 -1.96 197030.0 -410000.0 -1.93 -2.7496 -1.0 3186312 PK04_093298 OCCCOc1ccc(cc1)C2=N[C@](CCS(=O)(=O)c3ccccc3)(CO2)C(=O)NCc4ccccc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 P01 compound treatment 105410.0 -460000.0 -2.3 179290.0 -427000.0 -2.01 -3.0476 -0.9977 3186313 PK04_093299 OCCCOc1ccc(cc1)C2=N[C@@]3(Cc4ccccc4N(CCS(=O)(=O)c5ccccc5)C3=O)[C@@H](O2)c6ccccc6 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 P02 compound treatment 32080.0 -534000.0 -2.67 46720.0 -560000.0 -2.63 -3.7475 -1.0 3186314 PK04_093300 OCCCOc1ccc(cc1)C2=N[C@@](Cc3ccccc3N=[N+]=[N-])([C@@H](O2)c4ccccc4N=[N+]=[N-])C(=O)N5CCOCC5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 P03 compound treatment 91240.0 -475000.0 -2.37 92420.0 -514000.0 -2.42 -3.3866 -0.9999 3067960 PK04_093301 OCCCOc1ccc(cc1)C2=N[C@@]3(Cc4ccccc4)[C@@H](O2)c5ccccc5CN(CC=C)C3=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 P04 compound treatment 23910.0 -542000.0 -2.71 31890.0 -575000.0 -2.7 -3.8257 -1.0 3186315 PK04_093302 CN(C)C(=O)[C@]1(Cc2ccccc2N=[N+]=[N-])N=C(O[C@@H]1c3ccccc3N=[N+]=[N-])c4ccc(OCCCO)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 P05 compound treatment 157550.0 -408000.0 -2.04 138760.0 -468000.0 -2.2 -2.9983 -0.9993 3186316 PK04_093303 OCCCOc1ccc(cc1)C2=N[C@@]3(CC=C)[C@@H](O2)c4ccccc4N(CC=C)C3=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 P06 compound treatment 130990.0 -435000.0 -2.17 81350.0 -525000.0 -2.47 -3.283 -0.9979 3067963 PK04_093304 OCCCOc1ccc(cc1)C2=N[C@@](Cc3ccccc3N=[N+]=[N-])([C@@H](O2)c4ccccc4N=[N+]=[N-])C(=O)NCCN5CCOCC5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 P07 compound treatment 248980.0 -317000.0 -1.58 258520.0 -348000.0 -1.64 -2.277 -0.9999 3186317 PK04_093305 OCCCOc1ccc(cc1)C2=N[C@@]3(CO2)Cc4ccccc4N(CC=C)C3=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 P08 compound treatment 111520.0 -454000.0 -2.27 143090.0 -464000.0 -2.18 -3.1464 -0.9998 3186362 PK04_093306 COCCCNC(=O)[C@]1(Cc2ccccc2)N=C(O[C@@H]1c3ccccc3CN=[N+]=[N-])c4ccc(OCCCO)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 P09 compound treatment 110210.0 -456000.0 -2.28 120960.0 -486000.0 -2.28 -3.2246 -1.0 3067965 PK04_093307 OCCCOc1ccc(cc1)C2=N[C@]3(Cc4ccccc4CN(CCS(=O)(=O)c5ccccc5)C3=O)[C@H](O2)c6ccccc6 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 P10 compound treatment 163760.0 -402000.0 -2.01 167140.0 -439000.0 -2.07 -2.8819 -0.9999 3186363 PK04_093308 COCCCNC(=O)[C@]1(CC=C)N=C(O[C@@H]1c2ccccc2)c3ccc(OCCCO)cc3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 P11 mock treatment 293880.0 -272000.0 -1.36 236130.0 -371000.0 -1.74 -2.1929 -0.9924 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 P12 mock treatment 341880.0 -224000.0 -1.12 377930.0 -229000.0 -1.08 -1.5518 -0.9998 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 P13 compound treatment 90970.0 -475000.0 -2.37 142790.0 -464000.0 -2.18 -3.22 -0.9991 3186364 PK04_093309 OCCCOc1ccc(cc1)C2=N[C@@]3(Cc4ccccc4)[C@@H](O2)c5ccccc5N(CCS(=O)(=O)c6ccccc6)C3=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 P14 compound treatment 151790.0 -414000.0 -2.07 386780.0 -220000.0 -1.03 -2.1937 -0.9487 3067968 PK04_093310 CC(C)(C)OC(=O)CC[C@@]1(N=C(O[C@H]1c2ccccc2)c3ccc(OCCCO)cc3)C(=O)N4CCCCC4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 P15 compound treatment 157960.0 -408000.0 -2.04 223520.0 -383000.0 -1.8 -2.7149 -0.9981 3186365 PK04_093311 OCCCOc1ccc(cc1)C2=N[C@]3(CCS(=O)(=O)c4ccccc4)[C@H](O2)c5ccccc5N(CC=C)C3=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 P16 compound treatment 328440.0 -237000.0 -1.19 362560.0 -244000.0 -1.15 -1.6504 -0.9999 3186366 PK04_093312 OCCCOc1ccc(cc1)C2=N[C@@](CCS(=O)(=O)c3ccccc3)([C@@H](O2)c4ccccc4CN=[N+]=[N-])C(=O)NCC(O)CO 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 P17 compound treatment 121250.0 -445000.0 -2.22 132610.0 -474000.0 -2.23 -3.1469 -1.0 3067970 PK04_093313 OCCCOc1ccc(cc1)C2=N[C@]3(Cc4ccccc4)[C@H](O2)c5ccccc5CN(CC=C)C3=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 P18 compound treatment 106330.0 -460000.0 -2.3 130950.0 -476000.0 -2.24 -3.2051 -0.9999 3186367 PK04_093314 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3)([C@H](O2)c4ccccc4)C(=O)NCCN5CCOCC5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 P19 compound treatment 121560.0 -444000.0 -2.22 167680.0 -439000.0 -2.06 -3.0292 -0.9994 3067972 PK04_093315 OCCCOc1ccc(cc1)C2=N[C@]3(Cc4ccccc4CN(CC=C)C3=O)[C@H](O2)c5ccccc5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 P20 compound treatment 59410.0 -506000.0 -2.53 132820.0 -474000.0 -2.23 -3.3646 -0.998 3186368 PK04_093316 CC(C)(C)OC(=O)CC[C@@]1(N=C(O[C@H]1c2ccccc2CN=[N+]=[N-])c3ccc(OCCCO)cc3)C(=O)N4CCCCC4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 P21 compound treatment 112670.0 -453000.0 -2.26 133610.0 -473000.0 -2.22 -3.1739 -1.0 3067974 PK04_093317 CC(=O)N1Cc2ccccc2C[C@@]3(N=C(O[C@H]3c4ccccc4)c5ccc(OCCCO)cc5)C1=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 P22 compound treatment 276770.0 -289000.0 -1.44 304840.0 -302000.0 -1.42 -2.0248 -1.0 3186369 PK04_093318 NC(=O)[C@@]1(Cc2ccccc2CN=[N+]=[N-])COC(=N1)c3ccc(OCCCO)cc3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 P23 compound treatment 197650.0 -368000.0 -1.84 256250.0 -350000.0 -1.65 -2.4659 -0.9985 3067976 PK04_093319 CC(=O)N1Cc2ccccc2C[C@@]3(COC(=N3)c4ccc(OCCCO)cc4)C1=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2093 P24 compound treatment 41870.0 -524000.0 -2.62 105170.0 -501000.0 -2.36 -3.5185 -0.9987 3186370 PK04_093320 CC(C)(C)OC(=O)CC[C@]1(N=C(O[C@@H]1c2ccccc2)c3ccc(OCCCO)cc3)C(=O)NCc4ccccc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 A01 compound treatment 114170.0 -417000.0 -2.08 119490.0 -322000.0 -1.52 -2.5438 -0.9878 3186371 PK04_094001 OCCCOc1ccc(cc1)C2=N[C@@](Cc3ccccc3CN=[N+]=[N-])([C@@H](O2)c4ccccc4CN=[N+]=[N-])C(=O)NCCN5CCOCC5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 A02 compound treatment 99240.0 -432000.0 -2.16 116760.0 -325000.0 -1.53 -2.6056 -0.9857 3067979 PK04_094002 COCCCNC(=O)[C@]1(Cc2ccccc2)N=C(O[C@@H]1c3ccccc3N=[N+]=[N-])c4ccc(OCCCO)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 A03 compound treatment 207280.0 -324000.0 -1.62 140720.0 -301000.0 -1.42 -2.1444 -0.9978 3068002 PK04_094003 OCCCOc1ccc(cc1)C2=N[C@@](Cc3ccccc3CN=[N+]=[N-])([C@@H](O2)c4ccccc4N=[N+]=[N-])C(=O)N5CCOCC5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 A04 compound treatment 300580.0 -231000.0 -1.15 262770.0 -179000.0 -0.84 -1.4089 -0.9881 3186372 PK04_094004 COCCCNC(=O)[C@@]1(CCS(=O)(=O)c2ccccc2)N=C(O[C@H]1c3ccccc3N=[N+]=[N-])c4ccc(OCCCO)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 A05 compound treatment 212830.0 -318000.0 -1.59 404160.0 -37400.0 -0.18 -1.2486 -0.7806 3068007 PK04_094005 NC(=O)[C@@]1(CCS(=O)(=O)c2ccccc2)N=C(O[C@H]1c3ccccc3)c4ccc(OCCCO)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 A06 compound treatment 343940.0 -187000.0 -0.93 181120.0 -260000.0 -1.23 -1.5274 -0.9911 3186373 PK04_094006 CN(C)C(=O)[C@]1(Cc2ccccc2CN=[N+]=[N-])N=C(O[C@@H]1c3ccccc3)c4ccc(OCCCO)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 A07 compound treatment 227540.0 -304000.0 -1.52 247790.0 -194000.0 -0.91 -1.7167 -0.9704 3186374 PK04_094007 OCCCOc1ccc(cc1)C2=N[C@@](Cc3ccccc3CN=[N+]=[N-])([C@@H](O2)c4ccccc4CN=[N+]=[N-])C(=O)NCC(O)CO 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 A08 compound treatment 317120.0 -214000.0 -1.07 191770.0 -250000.0 -1.18 -1.5867 -0.9989 3068010 PK04_094008 NC(=O)[C@@]1(Cc2ccccc2N=[N+]=[N-])N=C(O[C@H]1c3ccccc3N=[N+]=[N-])c4ccc(OCCCO)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 A09 compound treatment 364320.0 -167000.0 -0.83 400640.0 -40900.0 -0.19 -0.7253 -0.8482 3186375 PK04_094009 CN(C)C(=O)[C@@]1(CCC(=O)OC(C)(C)C)N=C(O[C@H]1c2ccccc2)c3ccc(OCCCO)cc3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 A10 compound treatment 265660.0 -265000.0 -1.33 212480.0 -229000.0 -1.08 -1.6995 -0.9947 3068013 PK04_094010 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3CN=[N+]=[N-])([C@H](O2)c4ccccc4N=[N+]=[N-])C(=O)NCCN5CCOCC5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 A11 compound treatment 153180.0 -378000.0 -1.89 162960.0 -279000.0 -1.31 -2.2615 -0.9841 3186376 PK04_094011 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3N=[N+]=[N-])([C@H](O2)c4ccccc4N=[N+]=[N-])C(=O)NCc5ccccc5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 A12 compound treatment 192600.0 -339000.0 -1.69 179040.0 -263000.0 -1.23 -2.0688 -0.9881 3186377 PK04_094012 OCCCOc1ccc(cc1)C2=N[C@](CCS(=O)(=O)c3ccccc3)([C@H](O2)c4ccccc4)C(=O)N5CCCCC5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 A13 mock treatment 399010.0 -132000.0 -0.66 446270.0 4690.0 0.02 -0.451 -0.6831 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 A14 mock treatment 475710.0 -55400.0 -0.28 196060.0 -246000.0 -1.15 -1.0123 -0.8524 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 A15 compound treatment 201030.0 -330000.0 -1.65 295700.0 -146000.0 -0.69 -1.651 -0.9245 3068016 PK04_094013 CN(C)C(=O)[C@]1(Cc2ccccc2CN=[N+]=[N-])N=C(O[C@@H]1c3ccccc3CN=[N+]=[N-])c4ccc(OCCCO)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 A16 compound treatment 154970.0 -376000.0 -1.88 154940.0 -287000.0 -1.35 -2.2818 -0.9868 3186378 PK04_094014 OCCCOc1ccc(cc1)C2=N[C@@](Cc3ccccc3)([C@@H](O2)c4ccccc4N=[N+]=[N-])C(=O)NCCN5CCOCC5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 A17 compound treatment 216640.0 -314000.0 -1.57 176830.0 -265000.0 -1.25 -1.9912 -0.9934 3068018 PK04_094015 OCCCOc1ccc(cc1)C2=N[C@@](CCS(=O)(=O)c3ccccc3)([C@@H](O2)c4ccccc4N=[N+]=[N-])C(=O)NCCN5CCOCC5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 A18 compound treatment 196610.0 -335000.0 -1.67 146000.0 -296000.0 -1.39 -2.1645 -0.9958 3186379 PK04_094016 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3)([C@H](O2)c4ccccc4)C(=O)N5CCCCC5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 A19 compound treatment 206320.0 -325000.0 -1.62 157640.0 -284000.0 -1.34 -2.0915 -0.9953 3186380 PK04_094017 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3CN=[N+]=[N-])([C@H](O2)c4ccccc4)C(=O)N5CCOCC5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 A20 compound treatment 227200.0 -304000.0 -1.52 367610.0 -74000.0 -0.35 -1.3194 -0.8472 3068020 PK04_094018 NC(=O)[C@]1(Cc2ccccc2N=[N+]=[N-])N=C(O[C@@H]1c3ccccc3N=[N+]=[N-])c4ccc(OCCCO)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 A21 compound treatment 471250.0 -59900.0 -0.3 325650.0 -116000.0 -0.55 -0.597 -0.96 3186381 PK04_094019 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3)(CO2)C(=O)N4CCOCC4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 A22 compound treatment 474630.0 -56500.0 -0.28 276060.0 -166000.0 -0.78 -0.75 -0.9057 3186437 PK04_094020 CC(C)(C)OC(=O)CC[C@@]1(N=C(O[C@H]1c2ccccc2)c3ccc(OCCCO)cc3)C(=O)NCC(O)CO 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 A23 compound treatment 250110.0 -281000.0 -1.4 180190.0 -261000.0 -1.23 -1.8618 -0.9978 3068021 PK04_094021 CC(C)(C)OC(=O)CC[C@]1(N=C(O[C@@H]1c2ccccc2CN=[N+]=[N-])c3ccc(OCCCO)cc3)C(=O)NCc4ccccc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 A24 compound treatment 233860.0 -297000.0 -1.48 440670.0 -915.0 0.0 -1.0529 -0.7092 3186438 PK04_094022 COCCCNC(=O)[C@@]1(CCS(=O)(=O)c2ccccc2)N=C(O[C@H]1c3ccccc3CN=[N+]=[N-])c4ccc(OCCCO)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 B01 compound treatment 101230.0 -430000.0 -2.15 250930.0 -191000.0 -0.9 -2.1523 -0.925 3186439 PK04_094023 CCCN1C(=O)[C@]2(CCS(=O)(=O)c3ccccc3)N=C(O[C@@H]2c4ccccc14)c5ccc(OCCCO)cc5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 B02 compound treatment 282200.0 -249000.0 -1.24 254200.0 -187000.0 -0.88 -1.5023 -0.9858 3089331 PK04_094024 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2ccccc2)[C@H](OC(=O)Nc3ccccc3)[C@H]1OC(=O)Nc4ccccc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 B03 compound treatment 187150.0 -344000.0 -1.72 327150.0 -114000.0 -0.54 -1.5954 -0.8862 3068022 PK04_094025 CCCN1C(=O)[C@]2(Cc3ccccc13)N=C(O[C@@H]2c4ccccc4)c5ccc(OCCCO)cc5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 B04 compound treatment 292610.0 -239000.0 -1.19 210520.0 -231000.0 -1.09 -1.6109 -0.999 3089332 PK04_094026 CCc1cccc(NC(=O)O[C@@H]2[C@@H](CO)O[C@H](OC)[C@H](OC(=O)Nc3ccccc3)[C@H]2OC(=O)Nc4ccccc4)c1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 B05 compound treatment 304250.0 -227000.0 -1.13 159220.0 -282000.0 -1.33 -1.7404 -0.9969 3186440 PK04_094027 CCCN1C(=O)[C@@]2(CCS(=O)(=O)c3ccccc3)N=C(O[C@H]2c4ccccc14)c5ccc(OCCCO)cc5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 B06 compound treatment 405980.0 -125000.0 -0.63 145240.0 -296000.0 -1.39 -1.4276 -0.9345 3000708 PK04_094028 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2cccc(F)c2)[C@H](OC(=O)Nc3ccccc3)[C@H]1OC(=O)Nc4ccccc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 B07 compound treatment 149160.0 -382000.0 -1.91 136670.0 -305000.0 -1.43 -2.3631 -0.9901 3068023 PK04_094029 CN1C(=O)[C@]2(Cc3ccccc3)N=C(O[C@@H]2c4ccccc14)c5ccc(OCCCO)cc5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 B08 compound treatment 309640.0 -221000.0 -1.11 281490.0 -160000.0 -0.75 -1.3147 -0.9824 3089333 PK04_094030 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2ccc(OC)cc2)[C@H](OC(=O)Nc3ccccc3)[C@H]1OC(=O)Nc4ccccc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 B09 compound treatment 219200.0 -312000.0 -1.56 258670.0 -183000.0 -0.86 -1.71 -0.9608 3186441 PK04_094031 CN1C(=O)[C@@]2(CC=C)N=C(O[C@H]2c3ccccc13)c4ccc(OCCCO)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 B10 compound treatment 274720.0 -256000.0 -1.28 231250.0 -210000.0 -0.99 -1.6051 -0.9919 3089654 PK04_094032 CCOC(=O)c1ccc(NC(=O)O[C@@H]2[C@@H](CO)O[C@H](OC)[C@H](OC(=O)Nc3ccccc3)[C@H]2OC(=O)Nc4ccccc4)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 B11 compound treatment 195130.0 -336000.0 -1.68 138600.0 -303000.0 -1.43 -2.1943 -0.9967 3186442 PK04_094033 OCCCOc1ccc(cc1)C2=N[C@]3(Cc4ccccc4)[C@H](O2)c5ccccc5N(Cc6ccccc6)C3=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 B12 compound treatment 124520.0 -407000.0 -2.03 162260.0 -279000.0 -1.31 -2.365 -0.9778 3089334 PK04_094034 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2ccc(cc2)C(F)(F)F)[C@H](OC(=O)Nc3ccccc3)[C@H]1OC(=O)Nc4ccccc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 B13 mock treatment 525360.0 -5760.0 -0.03 468170.0 26600.0 0.13 0.0681 0.5305 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 B14 mock treatment 570810.0 39700.0 0.2 513120.0 71500.0 0.34 0.3781 0.9682 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 B15 compound treatment 215590.0 -316000.0 -1.58 215520.0 -226000.0 -1.06 -1.8662 -0.9817 3068024 PK04_094035 OCCCOc1ccc(cc1)C2=N[C@]3(CCS(=O)(=O)c4ccccc4)[C@H](O2)c5ccccc5N(Cc6ccccc6)C3=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 B16 compound treatment 149050.0 -382000.0 -1.91 120930.0 -321000.0 -1.51 -2.4158 -0.9932 3000709 PK04_094036 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2c(C)cccc2OC)[C@H](OC(=O)Nc3ccccc3)[C@H]1OC(=O)Nc4ccccc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 B17 compound treatment 264710.0 -266000.0 -1.33 249850.0 -192000.0 -0.9 -1.5786 -0.9821 3186443 PK04_094037 OCCCOc1ccc(cc1)C2=N[C@]3(CCS(=O)(=O)c4ccccc4)[C@H](O2)c5ccccc5CN(Cc6ccccc6)C3=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 B18 compound treatment 276970.0 -254000.0 -1.27 264610.0 -177000.0 -0.83 -1.4862 -0.9791 3089363 PK04_094038 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2ccc3OCOc3c2)[C@H](OC(=O)Nc4ccccc4)[C@H]1OC(=O)Nc5ccccc5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 B19 compound treatment 159770.0 -371000.0 -1.85 185650.0 -256000.0 -1.2 -2.1627 -0.9781 3068025 PK04_094039 OCCCOc1ccc(cc1)C2=N[C@@]3(Cc4ccccc4)[C@@H](O2)c5ccccc5N(Cc6ccccc6)C3=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 B20 compound treatment 191070.0 -340000.0 -1.7 119140.0 -322000.0 -1.52 -2.2734 -0.9984 3089652 PK04_094040 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2ccccc2c3ccccc3)[C@H](OC(=O)Nc4ccccc4)[C@H]1OC(=O)Nc5ccccc5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 B21 compound treatment 219420.0 -312000.0 -1.56 292540.0 -149000.0 -0.7 -1.5965 -0.9351 3186444 PK04_094041 OCCCOc1ccc(cc1)C2=N[C@@]3(Cc4ccccc4)[C@@H](O2)c5ccccc5CN(Cc6ccccc6)C3=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 B22 compound treatment 194100.0 -337000.0 -1.68 217040.0 -225000.0 -1.06 -1.9371 -0.9748 3089653 PK04_094042 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2ccc(Oc3ccccc3)cc2)[C@H](OC(=O)Nc4ccccc4)[C@H]1OC(=O)Nc5ccccc5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 B23 compound treatment 195550.0 -336000.0 -1.68 299870.0 -142000.0 -0.67 -1.6565 -0.9184 3186445 PK04_094043 OCCCOc1ccc(cc1)C2=N[C@]3(CC=C)[C@H](O2)c4ccccc4CN(Cc5ccccc5)C3=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 B24 compound treatment 247720.0 -283000.0 -1.42 138650.0 -303000.0 -1.42 -2.0084 -1.0 3089657 PK04_094044 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2ccccc2)[C@H](OC(=O)Nc3ccc4OCOc4c3)[C@H]1OC(=O)Nc5ccc6OCOc6c5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 C01 compound treatment 208960.0 -322000.0 -1.61 264990.0 -177000.0 -0.83 -1.7251 -0.9527 3068026 PK04_094045 CN(C)C(=O)[C@@]1(CCS(=O)(=O)c2ccccc2)N=C(O[C@H]1c3ccccc3CN=[N+]=[N-])c4ccc(OCCCO)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 C02 compound treatment 196250.0 -335000.0 -1.67 112050.0 -330000.0 -1.55 -2.2787 -0.9993 3068051 PK04_094046 CN(C)C(=O)[C@]1(Cc2ccccc2N=[N+]=[N-])N=C(O[C@@H]1c3ccccc3CN=[N+]=[N-])c4ccc(OCCCO)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 C03 compound treatment 152320.0 -379000.0 -1.89 123840.0 -318000.0 -1.49 -2.3946 -0.9932 3068052 PK04_094047 OCCCOc1ccc(cc1)C2=N[C@@](Cc3ccccc3CN=[N+]=[N-])([C@@H](O2)c4ccccc4)C(=O)NCCN5CCOCC5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 C04 compound treatment 501810.0 -29300.0 -0.15 441780.0 195.0 0.0 -0.1029 -0.7027 3068053 PK04_094048 OCCCOc1ccc(cc1)C2=N[C@](CC=C)(CO2)C(=O)N3CCOCC3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 C05 compound treatment 290340.0 -241000.0 -1.2 330890.0 -111000.0 -0.52 -1.2185 -0.9298 3068054 PK04_094049 COCCCNC(=O)[C@@]1(Cc2ccccc2N=[N+]=[N-])N=C(O[C@H]1c3ccccc3)c4ccc(OCCCO)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 C06 compound treatment 253810.0 -277000.0 -1.39 279720.0 -162000.0 -0.76 -1.5177 -0.9603 3186446 PK04_094050 CC(C)(C)OC(=O)CC[C@@]1(N=C(O[C@H]1c2ccccc2)c3ccc(OCCCO)cc3)C(=O)NCc4ccccc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 C07 compound treatment 450400.0 -80700.0 -0.4 347750.0 -93800.0 -0.44 -0.5972 -0.999 3068055 PK04_094051 CC(C)(C)OC(=O)CC[C@@]1(N=C(O[C@H]1c2ccccc2CN=[N+]=[N-])c3ccc(OCCCO)cc3)C(=O)N4CCOCC4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 C08 compound treatment 422330.0 -109000.0 -0.54 337920.0 -104000.0 -0.49 -0.729 -0.9985 3186447 PK04_094052 COCCCNC(=O)[C@]1(CCC(=O)OC(C)(C)C)N=C(O[C@@H]1c2ccccc2CN=[N+]=[N-])c3ccc(OCCCO)cc3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 C09 compound treatment 414250.0 -117000.0 -0.58 272000.0 -170000.0 -0.8 -0.9768 -0.9882 3068056 PK04_094053 OCCCOc1ccc(cc1)C2=N[C@@](CCS(=O)(=O)c3ccccc3)([C@@H](O2)c4ccccc4CN=[N+]=[N-])C(=O)NCc5ccccc5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 C10 compound treatment 120130.0 -411000.0 -2.05 105360.0 -336000.0 -1.58 -2.5698 -0.9917 3186448 PK04_094054 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3N=[N+]=[N-])([C@H](O2)c4ccccc4N=[N+]=[N-])C(=O)NCCN5CCOCC5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 C11 mock treatment 481230.0 -49900.0 -0.25 411770.0 -29800.0 -0.14 -0.2754 -0.963 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 C12 mock treatment 566100.0 35000.0 0.17 440480.0 -1100.0 -0.01 0.1199 0.6858 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 C13 compound treatment 483250.0 -47900.0 -0.24 431840.0 -9740.0 -0.05 -0.2015 -0.8276 3186449 PK04_094055 CC(C)(C)OC(=O)CC[C@]1(N=C(O[C@@H]1c2ccccc2)c3ccc(OCCCO)cc3)C(=O)N 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 C14 compound treatment 302150.0 -229000.0 -1.14 219550.0 -222000.0 -1.04 -1.5471 -0.999 3068057 PK04_094056 OCCCOc1ccc(cc1)C2=N[C@@](CC=C)([C@@H](O2)c3ccccc3CN=[N+]=[N-])C(=O)NCc4ccccc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 C15 mock treatment 266040.0 -265000.0 -1.32 485760.0 44200.0 0.21 -0.7892 -0.5889 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 C16 mock treatment 460910.0 -70200.0 -0.35 421810.0 -19800.0 -0.09 -0.3137 -0.8648 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 C17 compound treatment 398920.0 -132000.0 -0.66 274340.0 -167000.0 -0.79 -1.0231 -0.9962 3186450 PK04_094057 NC(=O)[C@@]1(CC=C)N=C(O[C@H]1c2ccccc2)c3ccc(OCCCO)cc3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 C18 compound treatment 231150.0 -300000.0 -1.5 202560.0 -239000.0 -1.12 -1.8544 -0.99 3186451 PK04_094058 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3)([C@H](O2)c4ccccc4CN=[N+]=[N-])C(=O)N5CCOCC5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 C19 compound treatment 264830.0 -266000.0 -1.33 451840.0 10300.0 0.05 -0.9063 -0.681 3068058 PK04_094059 CC(C)(C)OC(=O)CC[C@]1(N=C(O[C@@H]1c2ccccc2CN=[N+]=[N-])c3ccc(OCCCO)cc3)C(=O)NCC(O)CO 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 C20 compound treatment 152520.0 -379000.0 -1.89 178690.0 -263000.0 -1.24 -2.2115 -0.9788 3186452 PK04_094060 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3N=[N+]=[N-])([C@H](O2)c4ccccc4)C(=O)NCc5ccccc5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 C21 compound treatment 326780.0 -204000.0 -1.02 436360.0 -5220.0 -0.02 -0.739 -0.7239 3068059 PK04_094061 NC(=O)[C@]1(CC=C)N=C(O[C@@H]1c2ccccc2N=[N+]=[N-])c3ccc(OCCCO)cc3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 C22 compound treatment 334900.0 -196000.0 -0.98 307730.0 -134000.0 -0.63 -1.1382 -0.9771 3186453 PK04_094062 NC(=O)[C@]1(CCS(=O)(=O)c2ccccc2)N=C(O[C@@H]1c3ccccc3N=[N+]=[N-])c4ccc(OCCCO)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 C23 compound treatment 236020.0 -295000.0 -1.47 375850.0 -65700.0 -0.31 -1.2608 -0.8372 3186454 PK04_094063 OCCCOc1ccc(cc1)C2=N[C@@](CC=C)([C@@H](O2)c3ccccc3)C(=O)NCC(O)CO 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 C24 compound treatment 352420.0 -179000.0 -0.89 473920.0 32300.0 0.15 -0.5236 -0.5783 3068060 PK04_094064 CC(C)(C)OC(=O)CC[C@@]1(N=C(O[C@H]1c2ccccc2CN=[N+]=[N-])c3ccc(OCCCO)cc3)C(=O)NCCN4CCOCC4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 D01 compound treatment 126570.0 -405000.0 -2.02 200770.0 -241000.0 -1.13 -2.2297 -0.9626 3186455 PK04_094065 CN1C(=O)[C@@]2(CCC(=O)OC(C)(C)C)N=C(O[C@H]2c3ccccc13)c4ccc(OCCCO)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 D02 compound treatment 359890.0 -171000.0 -0.86 331210.0 -110000.0 -0.52 -0.9718 -0.9714 3000713 PK04_094066 CCc1cccc(NC(=O)O[C@@H]2[C@@H](CO)O[C@H](OC)[C@H](OC(=O)Nc3ccc4OCOc4c3)[C@H]2OC(=O)Nc5ccc6OCOc6c5)c1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 D03 compound treatment 210360.0 -321000.0 -1.6 151240.0 -290000.0 -1.37 -2.0985 -0.9968 3186456 PK04_094067 CCCN1C(=O)[C@@]2(CCC(=O)OC(C)(C)C)N=C(O[C@H]2c3ccccc13)c4ccc(OCCCO)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 D04 compound treatment 293300.0 -238000.0 -1.19 197810.0 -244000.0 -1.15 -1.6507 -0.9998 3089658 PK04_094068 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2cccc(F)c2)[C@H](OC(=O)Nc3ccc4OCOc4c3)[C@H]1OC(=O)Nc5ccc6OCOc6c5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 D05 compound treatment 139600.0 -392000.0 -1.96 157020.0 -285000.0 -1.34 -2.3292 -0.9829 3068061 PK04_094069 CCCN1C(=O)[C@@]2(Cc3ccccc3)N=C(O[C@H]2c4ccccc14)c5ccc(OCCCO)cc5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 D06 compound treatment 218940.0 -312000.0 -1.56 373040.0 -68500.0 -0.32 -1.3305 -0.8356 3089659 PK04_094070 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2ccc(OC)cc2)[C@H](OC(=O)Nc3ccc4OCOc4c3)[C@H]1OC(=O)Nc5ccc6OCOc6c5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 D07 compound treatment 201540.0 -330000.0 -1.65 220820.0 -221000.0 -1.04 -1.8982 -0.9753 3186457 PK04_094071 CCCN1C(=O)[C@]2(CCC(=O)OC(C)(C)C)N=C(O[C@@H]2c3ccccc13)c4ccc(OCCCO)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 D08 compound treatment 341860.0 -189000.0 -0.95 286470.0 -155000.0 -0.73 -1.1843 -0.9918 3089664 PK04_094072 CCOC(=O)c1ccc(NC(=O)O[C@@H]2[C@@H](CO)O[C@H](OC)[C@H](OC(=O)Nc3ccc4OCOc4c3)[C@H]2OC(=O)Nc5ccc6OCOc6c5)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 D09 compound treatment 459220.0 -71900.0 -0.36 371860.0 -69700.0 -0.33 -0.4858 -0.999 3068062 PK04_094073 CCCN1C(=O)[C@@]2(CC=C)N=C(O[C@H]2c3ccccc13)c4ccc(OCCCO)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 D10 compound treatment 264210.0 -267000.0 -1.33 210120.0 -231000.0 -1.09 -1.7125 -0.9949 3000714 PK04_094074 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2ccc(cc2)C(F)(F)F)[C@H](OC(=O)Nc3ccc4OCOc4c3)[C@H]1OC(=O)Nc5ccc6OCOc6c5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 D11 mock treatment 578620.0 47500.0 0.24 498580.0 57000.0 0.27 0.3573 0.9981 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 D12 mock treatment 582930.0 51800.0 0.26 379710.0 -61900.0 -0.29 -0.0228 -0.0586 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 D13 compound treatment 457120.0 -74000.0 -0.37 255960.0 -186000.0 -0.87 -0.8787 -0.9268 3186504 PK04_094075 OCCCOc1ccc(cc1)C2=N[C@@]3(Cc4ccccc4)[C@@H](O2)c5ccccc5CN(C(=O)c6ccccc6)C3=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 D14 compound treatment 274170.0 -257000.0 -1.28 161310.0 -280000.0 -1.32 -1.8396 -0.9999 3089660 PK04_094076 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2c(C)cccc2OC)[C@H](OC(=O)Nc3ccc4OCOc4c3)[C@H]1OC(=O)Nc5ccc6OCOc6c5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 D15 mock treatment 541860.0 10700.0 0.05 416060.0 -25500.0 -0.12 -0.047 -0.3572 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 D16 mock treatment 614240.0 83100.0 0.42 490420.0 48800.0 0.23 0.456 0.9611 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 D17 compound treatment 216660.0 -314000.0 -1.57 175360.0 -266000.0 -1.25 -1.996 -0.9937 3186505 PK04_094077 OCCCOc1ccc(cc1)C2=N[C@@]3(Cc4ccccc4N(Cc5ccccc5)C3=O)[C@@H](O2)c6ccccc6 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 D18 compound treatment 223310.0 -308000.0 -1.54 189620.0 -252000.0 -1.19 -1.9251 -0.9917 3000715 PK04_094078 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2ccc3OCOc3c2)[C@H](OC(=O)Nc4ccc5OCOc5c4)[C@H]1OC(=O)Nc6ccc7OCOc7c6 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 D19 compound treatment 288990.0 -242000.0 -1.21 345550.0 -96000.0 -0.45 -1.1745 -0.9098 3068063 PK04_094079 OCCCOc1ccc(cc1)C2=N[C@@]3(CO2)Cc4ccccc4N(Cc5ccccc5)C3=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 D20 compound treatment 289810.0 -241000.0 -1.21 167680.0 -274000.0 -1.29 -1.7632 -0.9994 3089662 PK04_094080 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2ccccc2c3ccccc3)[C@H](OC(=O)Nc4ccc5OCOc5c4)[C@H]1OC(=O)Nc6ccc7OCOc7c6 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 D21 compound treatment 260000.0 -271000.0 -1.35 145440.0 -296000.0 -1.39 -1.9425 -0.9999 3186506 PK04_094081 OCCCOc1ccc(cc1)C2=N[C@]3(CC=C)[C@H](O2)c4ccccc4N(Cc5ccccc5)C3=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 D22 compound treatment 250610.0 -281000.0 -1.4 333540.0 -108000.0 -0.51 -1.35 -0.9058 3000716 PK04_094082 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2ccc(Oc3ccccc3)cc2)[C@H](OC(=O)Nc4ccc5OCOc5c4)[C@H]1OC(=O)Nc6ccc7OCOc7c6 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 D23 compound treatment 202790.0 -328000.0 -1.64 193630.0 -248000.0 -1.17 -1.9842 -0.9861 3068064 PK04_094083 CC(C)(C)OC(=O)CC[C@]12N=C(O[C@@H]2c3ccccc3N(Cc4ccccc4)C1=O)c5ccc(OCCCO)cc5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 D24 compound treatment 251590.0 -280000.0 -1.4 247240.0 -194000.0 -0.91 -1.6336 -0.9789 3000811 PK04_094084 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2ccccc2)[C@H](OC(=O)Nc3ccccc3c4ccccc4)[C@H]1OC(=O)Nc5ccccc5c6ccccc6 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 E01 mock treatment 559560.0 28400.0 0.14 478810.0 37200.0 0.18 0.2242 0.9946 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 E02 mock treatment 544650.0 13500.0 0.07 518120.0 76500.0 0.36 0.3023 0.8254 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 E03 compound treatment 467520.0 -63600.0 -0.32 447380.0 5800.0 0.03 -0.2053 -0.6441 3186507 PK04_094085 CN(C)C(=O)[C@]1(CCC(=O)OC(C)(C)C)N=C(O[C@@H]1c2ccccc2N=[N+]=[N-])c3ccc(OCCCO)cc3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 E04 compound treatment 206660.0 -324000.0 -1.62 378450.0 -63100.0 -0.3 -1.3559 -0.823 3186508 PK04_094086 COCCCNC(=O)[C@@]1(Cc2ccccc2CN=[N+]=[N-])N=C(O[C@H]1c3ccccc3)c4ccc(OCCCO)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 E05 compound treatment 604080.0 73000.0 0.36 489120.0 47500.0 0.22 0.4158 0.9725 3068065 PK04_094087 CC(C)(C)OC(=O)CC[C@@]1(COC(=N1)c2ccc(OCCCO)cc2)C(=O)NCC(O)CO 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 E06 compound treatment 538880.0 7760.0 0.04 214770.0 -227000.0 -1.07 -0.727 -0.681 3186509 PK04_094088 NC(=O)[C@@]1(Cc2ccccc2CN=[N+]=[N-])N=C(O[C@H]1c3ccccc3N=[N+]=[N-])c4ccc(OCCCO)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 E07 compound treatment 216770.0 -314000.0 -1.57 204070.0 -238000.0 -1.12 -1.9001 -0.9861 3068066 PK04_094089 CN(C)C(=O)[C@@]1(CCS(=O)(=O)c2ccccc2)COC(=N1)c3ccc(OCCCO)cc3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 E08 compound treatment 386960.0 -144000.0 -0.72 382340.0 -59200.0 -0.28 -0.7062 -0.9147 3186510 PK04_094090 OCCCOc1ccc(cc1)C2=N[C@](CC=C)([C@H](O2)c3ccccc3N=[N+]=[N-])C(=O)NCCN4CCOCC4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 E09 mock treatment 622670.0 91500.0 0.46 487000.0 45400.0 0.21 0.4744 0.9399 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 E10 mock treatment 373280.0 -158000.0 -0.79 499090.0 57500.0 0.27 -0.3662 -0.4394 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 E11 compound treatment 179770.0 -351000.0 -1.75 181710.0 -260000.0 -1.22 -2.1052 -0.9844 3186511 PK04_094091 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3N=[N+]=[N-])([C@H](O2)c4ccccc4CN=[N+]=[N-])C(=O)NCc5ccccc5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 E12 compound treatment 615200.0 84100.0 0.42 471690.0 30100.0 0.14 0.3971 0.896 3068067 PK04_094092 OCCCOc1ccc(cc1)C2=N[C@](CC=C)(CO2)C(=O)NCC(O)CO 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 E13 compound treatment 423040.0 -108000.0 -0.54 258290.0 -183000.0 -0.86 -0.9913 -0.9746 3186512 PK04_094093 OCCCOc1ccc(cc1)C2=N[C@@](Cc3ccccc3N=[N+]=[N-])([C@@H](O2)c4ccccc4)C(=O)NCC(O)CO 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 E14 compound treatment 328960.0 -202000.0 -1.01 382960.0 -58600.0 -0.28 -0.9089 -0.8684 3068068 PK04_094094 NC(=O)[C@@]1(Cc2ccccc2N=[N+]=[N-])N=C(O[C@H]1c3ccccc3)c4ccc(OCCCO)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 E15 compound treatment 456380.0 -74700.0 -0.37 283170.0 -158000.0 -0.75 -0.7908 -0.9489 3186513 PK04_094095 OCCCOc1ccc(cc1)C2=N[C@](CC=C)([C@H](O2)c3ccccc3)C(=O)NCCN4CCOCC4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 E16 compound treatment 417160.0 -114000.0 -0.57 232480.0 -209000.0 -0.98 -1.0979 -0.9662 3068069 PK04_094096 CN(C)C(=O)[C@@]1(CCC(=O)OC(C)(C)C)N=C(O[C@H]1c2ccccc2N=[N+]=[N-])c3ccc(OCCCO)cc3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 E17 mock treatment 461360.0 -69800.0 -0.35 387870.0 -53700.0 -0.25 -0.425 -0.9875 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 E18 mock treatment 547200.0 16100.0 0.08 469620.0 28000.0 0.13 0.15 0.9717 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 E19 compound treatment 470690.0 -60400.0 -0.3 346580.0 -95000.0 -0.45 -0.5294 -0.9817 3186514 PK04_094097 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3N=[N+]=[N-])(CO2)C(=O)NCC(O)CO 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 E20 compound treatment 198050.0 -333000.0 -1.66 337600.0 -104000.0 -0.49 -1.5221 -0.8779 3186515 PK04_094098 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3)([C@H](O2)c4ccccc4)C(=O)NCc5ccccc5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 E21 compound treatment 206140.0 -325000.0 -1.62 230840.0 -211000.0 -0.99 -1.8487 -0.972 3068070 PK04_094099 CN(C)C(=O)[C@@]1(Cc2ccccc2N=[N+]=[N-])N=C(O[C@H]1c3ccccc3N=[N+]=[N-])c4ccc(OCCCO)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 E22 compound treatment 283870.0 -247000.0 -1.23 216100.0 -225000.0 -1.06 -1.6232 -0.9971 3186516 PK04_094100 OCCCOc1ccc(cc1)C2=N[C@@](Cc3ccccc3CN=[N+]=[N-])([C@@H](O2)c4ccccc4N=[N+]=[N-])C(=O)NCC(O)CO 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 E23 compound treatment 290980.0 -240000.0 -1.2 195840.0 -246000.0 -1.16 -1.6654 -0.9998 3068071 PK04_094101 OCCCOc1ccc(cc1)C2=N[C@](CC=C)([C@H](O2)c3ccccc3)C(=O)N4CCOCC4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 E24 compound treatment 182760.0 -348000.0 -1.74 146690.0 -295000.0 -1.39 -2.2111 -0.9937 3186517 PK04_094102 COCCCNC(=O)[C@@]1(Cc2ccccc2)N=C(O[C@H]1c3ccccc3N=[N+]=[N-])c4ccc(OCCCO)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 F01 mock treatment 327090.0 -204000.0 -1.02 216280.0 -225000.0 -1.06 -1.4699 -0.9998 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 F02 mock treatment 583090.0 52000.0 0.26 549820.0 108000.0 0.51 0.5435 0.9511 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 F03 compound treatment 135420.0 -396000.0 -1.98 181470.0 -260000.0 -1.22 -2.2626 -0.9734 3068072 PK04_094103 CN1C(=O)[C@]2(CCC(=O)OC(C)(C)C)N=C(O[C@@H]2c3ccccc13)c4ccc(OCCCO)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 F04 compound treatment 486520.0 -44600.0 -0.22 418100.0 -23500.0 -0.11 -0.2356 -0.9476 3000813 PK04_094104 CCc1cccc(NC(=O)O[C@@H]2[C@@H](CO)O[C@H](OC)[C@H](OC(=O)Nc3ccccc3c4ccccc4)[C@H]2OC(=O)Nc5ccccc5c6ccccc6)c1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 F05 compound treatment 133410.0 -398000.0 -1.99 132230.0 -309000.0 -1.46 -2.4335 -0.9883 3186518 PK04_094105 CN1C(=O)[C@]2(CC=C)N=C(O[C@@H]2c3ccccc13)c4ccc(OCCCO)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 F06 compound treatment 414140.0 -117000.0 -0.58 133020.0 -309000.0 -1.45 -1.4394 -0.92 3000814 PK04_094106 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2cccc(F)c2)[C@H](OC(=O)Nc3ccccc3c4ccccc4)[C@H]1OC(=O)Nc5ccccc5c6ccccc6 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 F07 compound treatment 143840.0 -387000.0 -1.93 140830.0 -301000.0 -1.41 -2.368 -0.9882 3186519 PK04_094107 OCCCOc1ccc(cc1)C2=N[C@]3(Cc4ccccc4CN(C(=O)c5ccccc5)C3=O)[C@H](O2)c6ccccc6 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 F08 compound treatment 327940.0 -203000.0 -1.01 272760.0 -169000.0 -0.79 -1.2791 -0.9926 3089667 PK04_094108 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2ccc(OC)cc2)[C@H](OC(=O)Nc3ccccc3c4ccccc4)[C@H]1OC(=O)Nc5ccccc5c6ccccc6 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 F09 mock treatment 611230.0 80100.0 0.4 491040.0 49500.0 0.23 0.4474 0.9667 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 F10 mock treatment 524690.0 -6430.0 -0.03 503770.0 62200.0 0.29 0.1841 0.6257 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 F11 compound treatment 263930.0 -267000.0 -1.33 301120.0 -140000.0 -0.66 -1.4108 -0.9474 3068073 PK04_094109 CC(C)(C)OC(=O)CC[C@@]12N=C(O[C@H]2c3ccccc3CN(C(=O)c4ccccc4)C1=O)c5ccc(OCCCO)cc5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 F12 compound treatment 288000.0 -243000.0 -1.21 205700.0 -236000.0 -1.11 -1.6432 -0.999 3089654 PK04_094110 CCOC(=O)c1ccc(NC(=O)O[C@@H]2[C@@H](CO)O[C@H](OC)[C@H](OC(=O)Nc3ccccc3)[C@H]2OC(=O)Nc4ccccc4)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 F13 compound treatment 473570.0 -57600.0 -0.29 236740.0 -205000.0 -0.96 -0.8846 -0.8797 3186520 PK04_094111 OCCCOc1ccc(cc1)C2=N[C@@]3(CC=C)[C@@H](O2)c4ccccc4CN(C(=O)c5ccccc5)C3=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 F14 compound treatment 206330.0 -325000.0 -1.62 181440.0 -260000.0 -1.22 -2.0123 -0.9903 3089708 PK04_094112 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2ccc(cc2)C(F)(F)F)[C@H](OC(=O)Nc3ccccc3c4ccccc4)[C@H]1OC(=O)Nc5ccccc5c6ccccc6 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 F15 compound treatment 279080.0 -252000.0 -1.26 234930.0 -207000.0 -0.97 -1.5775 -0.9918 3186521 PK04_094113 OCCCOc1ccc(cc1)C2=N[C@]3(Cc4ccccc4N(C(=O)c5ccccc5)C3=O)[C@H](O2)c6ccccc6 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 F16 compound treatment 179160.0 -352000.0 -1.76 143570.0 -298000.0 -1.4 -2.2342 -0.9937 3000817 PK04_094114 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2c(C)cccc2OC)[C@H](OC(=O)Nc3ccccc3c4ccccc4)[C@H]1OC(=O)Nc5ccccc5c6ccccc6 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 F17 mock treatment 518850.0 -12300.0 -0.06 305060.0 -137000.0 -0.64 -0.4974 -0.7711 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 F18 mock treatment 300570.0 -231000.0 -1.15 517920.0 76300.0 0.36 -0.5603 -0.4646 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 F19 compound treatment 299650.0 -231000.0 -1.16 194450.0 -247000.0 -1.16 -1.6394 -1.0 3068074 PK04_094115 OCCCOc1ccc(cc1)C2=N[C@]3(Cc4ccccc4)[C@H](O2)c5ccccc5CN(Cc6ccccc6)C3=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 F20 compound treatment 200890.0 -330000.0 -1.65 182450.0 -259000.0 -1.22 -2.0281 -0.9889 3089709 PK04_094116 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2ccc3OCOc3c2)[C@H](OC(=O)Nc4ccccc4c5ccccc5)[C@H]1OC(=O)Nc6ccccc6c7ccccc7 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 F21 compound treatment 518000.0 -13100.0 -0.07 322100.0 -119000.0 -0.56 -0.4437 -0.7842 3186522 PK04_094117 OCCCOc1ccc(cc1)C2=N[C@@]3(CO2)Cc4ccccc4CN(Cc5ccccc5)C3=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 F22 compound treatment 218840.0 -312000.0 -1.56 180240.0 -261000.0 -1.23 -1.9721 -0.9931 3000821 PK04_094118 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2ccccc2c3ccccc3)[C@H](OC(=O)Nc4ccccc4c5ccccc5)[C@H]1OC(=O)Nc6ccccc6c7ccccc7 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 F23 compound treatment 256490.0 -275000.0 -1.37 177960.0 -264000.0 -1.24 -1.8467 -0.9987 3186523 PK04_094119 CC(C)(C)OC(=O)CC[C@]12N=C(O[C@@H]2c3ccccc3CN(Cc4ccccc4)C1=O)c5ccc(OCCCO)cc5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 F24 compound treatment 168730.0 -362000.0 -1.81 285940.0 -156000.0 -0.73 -1.7975 -0.9207 3089711 PK04_094120 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2ccc(Oc3ccccc3)cc2)[C@H](OC(=O)Nc4ccccc4c5ccccc5)[C@H]1OC(=O)Nc6ccccc6c7ccccc7 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 G01 compound treatment 292890.0 -238000.0 -1.19 195680.0 -246000.0 -1.16 -1.6592 -0.9999 3068075 PK04_094121 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3N=[N+]=[N-])(CO2)C(=O)N4CCOCC4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 G02 compound treatment 388390.0 -143000.0 -0.71 502030.0 60400.0 0.28 -0.303 -0.3948 3186524 PK04_094122 COCCCNC(=O)[C@@]1(CCC(=O)OC(C)(C)C)COC(=N1)c2ccc(OCCCO)cc2 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 G03 mock treatment 518270.0 -12900.0 -0.06 193660.0 -248000.0 -1.17 -0.87 -0.7449 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 G04 mock treatment 601350.0 70200.0 0.35 186240.0 -255000.0 -1.2 -0.6012 -0.4805 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 G05 compound treatment 612910.0 81800.0 0.41 279640.0 -162000.0 -0.76 -0.2498 -0.289 3186575 PK04_094123 OCCCOc1ccc(cc1)C2=N[C@](CCS(=O)(=O)c3ccccc3)([C@H](O2)c4ccccc4N=[N+]=[N-])C(=O)NCCN5CCOCC5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 G06 compound treatment 223750.0 -307000.0 -1.54 146370.0 -295000.0 -1.39 -2.0674 -0.9987 3186576 PK04_094124 OCCCOc1ccc(cc1)C2=N[C@@](Cc3ccccc3N=[N+]=[N-])([C@@H](O2)c4ccccc4)C(=O)NCCN5CCOCC5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 G07 compound treatment 498760.0 -32400.0 -0.16 440030.0 -1550.0 -0.01 -0.1195 -0.7383 3068110 PK04_094125 OCCCOc1ccc(cc1)C2=N[C@@](CC=C)([C@@H](O2)c3ccccc3)C(=O)N4CCOCC4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 G08 compound treatment 234560.0 -297000.0 -1.48 372080.0 -69500.0 -0.33 -1.2785 -0.8429 3186577 PK04_094126 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3)([C@H](O2)c4ccccc4CN=[N+]=[N-])C(=O)NCC(O)CO 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 G09 compound treatment 331040.0 -200000.0 -1.0 136800.0 -305000.0 -1.43 -1.7203 -0.9844 3068111 PK04_094127 COCCCNC(=O)[C@]1(Cc2ccccc2CN=[N+]=[N-])N=C(O[C@@H]1c3ccccc3CN=[N+]=[N-])c4ccc(OCCCO)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 G10 compound treatment 396360.0 -135000.0 -0.67 372220.0 -69400.0 -0.33 -0.7066 -0.9447 3186578 PK04_094128 CN(C)C(=O)[C@]1(CC=C)N=C(O[C@@H]1c2ccccc2)c3ccc(OCCCO)cc3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 G11 compound treatment 508020.0 -23100.0 -0.12 237920.0 -204000.0 -0.96 -0.759 -0.7866 3186579 PK04_094129 COCCCNC(=O)[C@@]1(CC=C)N=C(O[C@H]1c2ccccc2CN=[N+]=[N-])c3ccc(OCCCO)cc3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 G12 compound treatment 539490.0 8370.0 0.04 366940.0 -74600.0 -0.35 -0.2187 -0.6186 3068112 PK04_094130 OCCCOc1ccc(cc1)C2=N[C@](CCS(=O)(=O)c3ccccc3)([C@H](O2)c4ccccc4)C(=O)NCC(O)CO 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 G13 compound treatment 579540.0 48400.0 0.24 522200.0 80600.0 0.38 0.4391 0.9764 3186580 PK04_094131 OCCCOc1ccc(cc1)C2=N[C@](CC=C)(CO2)C(=O)NCCN3CCOCC3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 G14 compound treatment 348010.0 -183000.0 -0.91 423430.0 -18200.0 -0.09 -0.7071 -0.7698 3186581 PK04_094132 OCCCOc1ccc(cc1)C2=N[C@](CCS(=O)(=O)c3ccccc3)([C@H](O2)c4ccccc4N=[N+]=[N-])C(=O)NCc5ccccc5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 G15 compound treatment 399420.0 -132000.0 -0.66 347050.0 -94500.0 -0.44 -0.7795 -0.9818 3068113 PK04_094133 OCCCOc1ccc(cc1)C2=N[C@](CCS(=O)(=O)c3ccccc3)([C@H](O2)c4ccccc4N=[N+]=[N-])C(=O)NCC(O)CO 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 G16 compound treatment 225120.0 -306000.0 -1.53 225760.0 -216000.0 -1.02 -1.7985 -0.9802 3186582 PK04_094134 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3)([C@H](O2)c4ccccc4)C(=O)N5CCOCC5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 G17 compound treatment 501920.0 -29200.0 -0.15 427250.0 -14300.0 -0.07 -0.1508 -0.9386 3186583 PK04_094135 OCCCOc1ccc(cc1)C2=N[C@@](CC=C)([C@@H](O2)c3ccccc3)C(=O)NCCN4CCOCC4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 G18 compound treatment 479370.0 -51800.0 -0.26 246720.0 -195000.0 -0.92 -0.8309 -0.8725 3068114 PK04_094136 NC(=O)[C@]1(Cc2ccccc2CN=[N+]=[N-])N=C(O[C@@H]1c3ccccc3N=[N+]=[N-])c4ccc(OCCCO)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 G19 mock treatment 595600.0 64500.0 0.32 502280.0 60700.0 0.29 0.4296 0.9982 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 G20 mock treatment 483880.0 -47200.0 -0.24 429490.0 -12100.0 -0.06 -0.2071 -0.8532 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 G21 compound treatment 400160.0 -131000.0 -0.65 207300.0 -234000.0 -1.1 -1.2417 -0.969 3186584 PK04_094137 OCCCOc1ccc(cc1)C2=N[C@@](CC=C)([C@@H](O2)c3ccccc3)C(=O)N4CCCCC4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 G22 compound treatment 329050.0 -202000.0 -1.01 245600.0 -196000.0 -0.92 -1.3655 -0.999 3068115 PK04_094138 COCCCNC(=O)[C@@]1(CCC(=O)OC(C)(C)C)N=C(O[C@H]1c2ccccc2N=[N+]=[N-])c3ccc(OCCCO)cc3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 G23 compound treatment 336850.0 -194000.0 -0.97 405810.0 -35800.0 -0.17 -0.8051 -0.8175 3186585 PK04_094139 CN(C)C(=O)[C@@]1(CC=C)N=C(O[C@H]1c2ccccc2CN=[N+]=[N-])c3ccc(OCCCO)cc3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 G24 compound treatment 373250.0 -158000.0 -0.79 430600.0 -11000.0 -0.05 -0.5941 -0.7518 3186586 PK04_094140 CC(C)(C)OC(=O)CC[C@@]1(COC(=N1)c2ccc(OCCCO)cc2)C(=O)NCc3ccccc3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 H01 compound treatment 106280.0 -425000.0 -2.12 166170.0 -275000.0 -1.3 -2.4164 -0.972 3068116 PK04_094141 CCCN1C(=O)[C@]2(Cc3ccccc3)N=C(O[C@@H]2c4ccccc14)c5ccc(OCCCO)cc5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 H02 compound treatment 213830.0 -317000.0 -1.58 279080.0 -163000.0 -0.76 -1.661 -0.9441 3000914 PK04_094142 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2ccccc2)[C@H](OC(=O)Nc3ccccc3)[C@@H]1OC(=O)Nc4ccccc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 H03 mock treatment 535380.0 4260.0 0.02 561710.0 120000.0 0.57 0.4146 0.7332 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 H04 mock treatment 199540.0 -332000.0 -1.66 517120.0 75500.0 0.36 -0.9198 -0.543 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 H05 compound treatment 148010.0 -383000.0 -1.91 246720.0 -195000.0 -0.92 -2.0011 -0.9432 3068117 PK04_094143 CCCN1C(=O)[C@]2(CC=C)N=C(O[C@@H]2c3ccccc13)c4ccc(OCCCO)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 H06 compound treatment 168750.0 -362000.0 -1.81 323520.0 -118000.0 -0.56 -1.6724 -0.8834 3089723 PK04_094144 CCc1cccc(NC(=O)O[C@@H]2[C@@H](CO)O[C@H](OC)[C@@H](OC(=O)Nc3ccccc3)[C@H]2OC(=O)Nc4ccccc4)c1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 H07 compound treatment 253220.0 -278000.0 -1.39 149960.0 -292000.0 -1.37 -1.9514 -1.0 3186589 PK04_094145 CN1C(=O)[C@@]2(Cc3ccccc3)N=C(O[C@H]2c4ccccc14)c5ccc(OCCCO)cc5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 H08 compound treatment 281290.0 -250000.0 -1.25 313220.0 -128000.0 -0.6 -1.3093 -0.9445 3089724 PK04_094146 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2cccc(F)c2)[C@H](OC(=O)Nc3ccccc3)[C@@H]1OC(=O)Nc4ccccc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 H09 compound treatment 383600.0 -148000.0 -0.74 170430.0 -271000.0 -1.28 -1.4228 -0.966 3186590 PK04_094147 OCCCOc1ccc(cc1)C2=N[C@@]3(CO2)Cc4ccccc4N(C(=O)c5ccccc5)C3=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 H10 compound treatment 209060.0 -322000.0 -1.61 169600.0 -272000.0 -1.28 -2.042 -0.9936 3000917 PK04_094148 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2ccc(OC)cc2)[C@H](OC(=O)Nc3ccccc3)[C@@H]1OC(=O)Nc4ccccc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 H11 compound treatment 464200.0 -66900.0 -0.33 188480.0 -253000.0 -1.19 -1.0782 -0.8719 3068119 PK04_094149 CC(C)(C)OC(=O)CC[C@]12N=C(O[C@@H]2c3ccccc3CN(C(=O)c4ccccc4)C1=O)c5ccc(OCCCO)cc5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 H12 compound treatment 199950.0 -331000.0 -1.65 250810.0 -191000.0 -0.9 -1.8041 -0.9587 3089768 PK04_094150 CCOC(=O)c1ccc(NC(=O)O[C@@H]2[C@@H](CO)O[C@H](OC)[C@@H](OC(=O)Nc3ccccc3)[C@H]2OC(=O)Nc4ccccc4)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 H13 compound treatment 369730.0 -161000.0 -0.81 191040.0 -251000.0 -1.18 -1.4033 -0.9828 3186593 PK04_094151 OCCCOc1ccc(cc1)C2=N[C@]3(CC=C)[C@H](O2)c4ccccc4CN(C(=O)c5ccccc5)C3=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 H14 compound treatment 517700.0 -13400.0 -0.07 402400.0 -39200.0 -0.18 -0.1777 -0.9062 3089763 PK04_094152 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2ccc(cc2)C(F)(F)F)[C@H](OC(=O)Nc3ccccc3)[C@@H]1OC(=O)Nc4ccccc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 H15 compound treatment 226200.0 -305000.0 -1.52 157170.0 -284000.0 -1.34 -2.0228 -0.9979 3186594 PK04_094153 OCCCOc1ccc(cc1)C2=N[C@@]3(CCS(=O)(=O)c4ccccc4)[C@@H](O2)c5ccccc5CN(C(=O)c6ccccc6)C3=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 H16 compound treatment 344350.0 -187000.0 -0.93 167520.0 -274000.0 -1.29 -1.5711 -0.9874 3089764 PK04_094154 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2c(C)cccc2OC)[C@H](OC(=O)Nc3ccccc3)[C@@H]1OC(=O)Nc4ccccc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 H17 compound treatment 392060.0 -139000.0 -0.69 477850.0 36300.0 0.17 -0.3705 -0.518 3068121 PK04_094155 OCCCOc1ccc(cc1)C2=N[C@@]3(CO2)Cc4ccccc4CN(C(=O)c5ccccc5)C3=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 H18 compound treatment 215150.0 -316000.0 -1.58 179520.0 -262000.0 -1.23 -1.9875 -0.9925 3000919 PK04_094156 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2ccc3OCOc3c2)[C@H](OC(=O)Nc4ccccc4)[C@@H]1OC(=O)Nc5ccccc5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 H19 mock treatment 241650.0 -289000.0 -1.45 376230.0 -65400.0 -0.31 -1.2397 -0.8387 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 H20 mock treatment 453000.0 -78100.0 -0.39 505730.0 64100.0 0.3 -0.0625 -0.1268 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 H21 compound treatment 214120.0 -317000.0 -1.58 162310.0 -279000.0 -1.31 -2.0484 -0.9957 3068122 PK04_094157 CC(C)(C)OC(=O)CC[C@@]12N=C(O[C@H]2c3ccccc3N(Cc4ccccc4)C1=O)c5ccc(OCCCO)cc5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 H22 compound treatment 208920.0 -322000.0 -1.61 150950.0 -291000.0 -1.37 -2.1045 -0.9967 3089766 PK04_094158 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2ccccc2c3ccccc3)[C@H](OC(=O)Nc4ccccc4)[C@@H]1OC(=O)Nc5ccccc5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 H23 compound treatment 424760.0 -106000.0 -0.53 252660.0 -189000.0 -0.89 -1.004 -0.9697 3068123 PK04_094159 OCCCOc1ccc(cc1)C2=N[C@@]3(CC=C)[C@@H](O2)c4ccccc4CN(Cc5ccccc5)C3=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 H24 compound treatment 244590.0 -287000.0 -1.43 156250.0 -285000.0 -1.34 -1.9609 -0.9995 3089769 PK04_094160 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2ccccc2)[C@H](OC(=O)Nc3ccc4OCOc4c3)[C@@H]1OC(=O)Nc5ccc6OCOc6c5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 I01 compound treatment 155890.0 -375000.0 -1.87 240290.0 -201000.0 -0.95 -1.9947 -0.95 3186651 PK04_094161 COCCCNC(=O)[C@]1(CC=C)N=C(O[C@@H]1c2ccccc2CN=[N+]=[N-])c3ccc(OCCCO)cc3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 I02 compound treatment 529730.0 -1390.0 -0.01 306280.0 -135000.0 -0.64 -0.4549 -0.7148 3068124 PK04_094162 COCCCNC(=O)[C@@]1(CC=C)N=C(O[C@H]1c2ccccc2)c3ccc(OCCCO)cc3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 I03 compound treatment 191060.0 -340000.0 -1.7 227140.0 -214000.0 -1.01 -1.9142 -0.969 3186652 PK04_094163 NC(=O)[C@]1(Cc2ccccc2N=[N+]=[N-])N=C(O[C@@H]1c3ccccc3CN=[N+]=[N-])c4ccc(OCCCO)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 I04 compound treatment 464030.0 -67100.0 -0.34 167700.0 -274000.0 -1.29 -1.1479 -0.8623 3068125 PK04_094164 OCCCOc1ccc(cc1)C2=N[C@@](CC=C)([C@@H](O2)c3ccccc3)C(=O)NCc4ccccc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 I05 mock treatment 595040.0 63900.0 0.32 507570.0 66000.0 0.31 0.4452 0.9999 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 I06 mock treatment 625440.0 94300.0 0.47 485120.0 43500.0 0.2 0.4779 0.9304 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 I07 compound treatment 247370.0 -284000.0 -1.42 300110.0 -141000.0 -0.67 -1.4727 -0.9406 3186653 PK04_094165 OCCCOc1ccc(cc1)C2=N[C@](CC=C)([C@H](O2)c3ccccc3CN=[N+]=[N-])C(=O)N4CCOCC4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 I08 compound treatment 626690.0 95600.0 0.48 320750.0 -121000.0 -0.57 -0.0644 -0.0867 3068126 PK04_094166 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3)(CO2)C(=O)NCC(O)CO 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 I09 compound treatment 595300.0 64200.0 0.32 418480.0 -23100.0 -0.11 0.1498 0.4426 3186654 PK04_094167 COCCCNC(=O)[C@]1(CCC(=O)OC(C)(C)C)N=C(O[C@@H]1c2ccccc2)c3ccc(OCCCO)cc3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 I10 compound treatment 186900.0 -344000.0 -1.72 152340.0 -289000.0 -1.36 -2.1777 -0.9933 3068572 PK04_094168 OCCCOc1ccc(cc1)C2=N[C@@](Cc3ccccc3CN=[N+]=[N-])([C@@H](O2)c4ccccc4)C(=O)NCC(O)CO 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 I11 compound treatment 231780.0 -299000.0 -1.5 196350.0 -245000.0 -1.15 -1.8728 -0.9918 3186655 PK04_094169 COCCCNC(=O)[C@]1(CCS(=O)(=O)c2ccccc2)N=C(O[C@@H]1c3ccccc3N=[N+]=[N-])c4ccc(OCCCO)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 I12 compound treatment 216970.0 -314000.0 -1.57 197920.0 -244000.0 -1.15 -1.9199 -0.9881 3186656 PK04_094170 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3N=[N+]=[N-])([C@H](O2)c4ccccc4N=[N+]=[N-])C(=O)N5CCCCC5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 I13 compound treatment 152890.0 -378000.0 -1.89 208850.0 -233000.0 -1.09 -2.1099 -0.9663 3068573 PK04_094171 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3N=[N+]=[N-])(CO2)C(=O)N4CCCCC4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 I14 compound treatment 420450.0 -111000.0 -0.55 276740.0 -165000.0 -0.78 -0.9391 -0.9862 3186657 PK04_094172 CN(C)C(=O)[C@@]1(CCS(=O)(=O)c2ccccc2)N=C(O[C@H]1c3ccccc3)c4ccc(OCCCO)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 I15 compound treatment 264320.0 -267000.0 -1.33 181470.0 -260000.0 -1.22 -1.8074 -0.9991 3068574 PK04_094173 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3N=[N+]=[N-])([C@H](O2)c4ccccc4CN=[N+]=[N-])C(=O)NCC(O)CO 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 I16 compound treatment 310480.0 -221000.0 -1.1 208680.0 -233000.0 -1.1 -1.5539 -1.0 3186658 PK04_094174 OCCCOc1ccc(cc1)C2=N[C@@](Cc3ccccc3CN=[N+]=[N-])([C@@H](O2)c4ccccc4CN=[N+]=[N-])C(=O)N5CCCCC5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 I17 compound treatment 295120.0 -236000.0 -1.18 207220.0 -234000.0 -1.1 -1.613 -0.9994 3186659 PK04_094175 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3CN=[N+]=[N-])([C@H](O2)c4ccccc4N=[N+]=[N-])C(=O)NCc5ccccc5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 I18 compound treatment 324320.0 -207000.0 -1.03 150210.0 -291000.0 -1.37 -1.6995 -0.9903 3068575 PK04_094176 OCCCOc1ccc(cc1)C2=N[C@@](Cc3ccccc3)([C@@H](O2)c4ccccc4N=[N+]=[N-])C(=O)N5CCOCC5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 I19 compound treatment 489810.0 -41300.0 -0.21 286640.0 -155000.0 -0.73 -0.6612 -0.873 3186660 PK04_094177 CN(C)C(=O)[C@]1(CCC(=O)OC(C)(C)C)N=C(O[C@@H]1c2ccccc2)c3ccc(OCCCO)cc3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 I20 compound treatment 277490.0 -254000.0 -1.27 422600.0 -19000.0 -0.09 -0.9589 -0.7551 3068577 PK04_094178 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3CN=[N+]=[N-])([C@H](O2)c4ccccc4N=[N+]=[N-])C(=O)N5CCCCC5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 I21 mock treatment 500640.0 -30500.0 -0.15 446150.0 4570.0 0.02 -0.0925 -0.6014 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 I22 mock treatment 579220.0 48100.0 0.24 456270.0 14700.0 0.07 0.2187 0.875 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 I23 compound treatment 259530.0 -272000.0 -1.36 370370.0 -71200.0 -0.33 -1.196 -0.856 3186661 PK04_094179 OCCCOc1ccc(cc1)C2=N[C@@](CC=C)([C@@H](O2)c3ccccc3CN=[N+]=[N-])C(=O)NCCN4CCOCC4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 I24 compound treatment 202170.0 -329000.0 -1.64 165930.0 -276000.0 -1.3 -2.0786 -0.9931 3186662 PK04_094180 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3CN=[N+]=[N-])([C@H](O2)c4ccccc4)C(=O)NCc5ccccc5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 J01 compound treatment 138370.0 -393000.0 -1.96 145400.0 -296000.0 -1.39 -2.3722 -0.9859 3068611 PK04_094181 CN1C(=O)[C@@]2(CCS(=O)(=O)c3ccccc3)N=C(O[C@H]2c4ccccc14)c5ccc(OCCCO)cc5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 J02 compound treatment 103630.0 -427000.0 -2.14 196590.0 -245000.0 -1.15 -2.3246 -0.9581 3089770 PK04_094182 CCc1cccc(NC(=O)O[C@@H]2[C@@H](CO)O[C@H](OC)[C@@H](OC(=O)Nc3ccc4OCOc4c3)[C@H]2OC(=O)Nc5ccc6OCOc6c5)c1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 J03 compound treatment 144320.0 -387000.0 -1.93 181920.0 -260000.0 -1.22 -2.2297 -0.9755 3068612 PK04_094183 OCCCOc1ccc(cc1)C2=N[C@]3(CCS(=O)(=O)c4ccccc4)[C@H](O2)c5ccccc5CN(C(=O)c6ccccc6)C3=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 J04 compound treatment 172570.0 -359000.0 -1.79 163930.0 -278000.0 -1.31 -2.1898 -0.988 3001007 PK04_094184 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2cccc(F)c2)[C@H](OC(=O)Nc3ccc4OCOc4c3)[C@@H]1OC(=O)Nc5ccc6OCOc6c5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 J05 mock treatment 238140.0 -293000.0 -1.46 499260.0 57700.0 0.27 -0.8429 -0.5664 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 J06 mock treatment 592070.0 60900.0 0.3 518760.0 77200.0 0.36 0.4719 0.9962 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 J07 compound treatment 196610.0 -335000.0 -1.67 281160.0 -160000.0 -0.75 -1.7149 -0.9355 3186665 PK04_094185 CC(C)(C)OC(=O)CC[C@@]12N=C(O[C@H]2c3ccccc3CN(Cc4ccccc4)C1=O)c5ccc(OCCCO)cc5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 J08 compound treatment 198810.0 -332000.0 -1.66 180520.0 -261000.0 -1.23 -2.0419 -0.989 3089771 PK04_094186 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2ccc(OC)cc2)[C@H](OC(=O)Nc3ccc4OCOc4c3)[C@@H]1OC(=O)Nc5ccc6OCOc6c5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 J09 compound treatment 218480.0 -313000.0 -1.56 205530.0 -236000.0 -1.11 -1.8893 -0.986 3186666 PK04_094187 OCCCOc1ccc(cc1)C2=N[C@@]3(Cc4ccccc4N(C(=O)c5ccccc5)C3=O)[C@@H](O2)c6ccccc6 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 J10 compound treatment 177060.0 -354000.0 -1.77 343270.0 -98300.0 -0.46 -1.5774 -0.863 3089776 PK04_094188 CCOC(=O)c1ccc(NC(=O)O[C@@H]2[C@@H](CO)O[C@H](OC)[C@@H](OC(=O)Nc3ccc4OCOc4c3)[C@H]2OC(=O)Nc5ccc6OCOc6c5)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 J11 compound treatment 560670.0 29500.0 0.15 331970.0 -110000.0 -0.52 -0.2602 -0.4852 3068615 PK04_094189 CCCN1C(=O)[C@]2(COC(=N2)c3ccc(OCCCO)cc3)Cc4ccccc14 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 J12 compound treatment 276180.0 -255000.0 -1.27 196850.0 -245000.0 -1.15 -1.7143 -0.9987 3001011 PK04_094190 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2ccc(cc2)C(F)(F)F)[C@H](OC(=O)Nc3ccc4OCOc4c3)[C@@H]1OC(=O)Nc5ccc6OCOc6c5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 J13 compound treatment 177620.0 -354000.0 -1.77 147380.0 -294000.0 -1.38 -2.227 -0.9927 3068616 PK04_094191 OCCCOc1ccc(cc1)C2=N[C@]3(Cc4ccccc4)[C@H](O2)c5ccccc5CN(C(=O)c6ccccc6)C3=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 J14 compound treatment 249240.0 -282000.0 -1.41 160590.0 -281000.0 -1.32 -1.9301 -0.9995 3089772 PK04_094192 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2c(C)cccc2OC)[C@H](OC(=O)Nc3ccc4OCOc4c3)[C@@H]1OC(=O)Nc5ccc6OCOc6c5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 J15 compound treatment 244960.0 -286000.0 -1.43 160910.0 -281000.0 -1.32 -1.9441 -0.9992 3068617 PK04_094193 OCCCOc1ccc(cc1)C2=N[C@@]3(Cc4ccccc4CN(C(=O)c5ccccc5)C3=O)[C@@H](O2)c6ccccc6 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 J16 compound treatment 293520.0 -238000.0 -1.19 176590.0 -265000.0 -1.25 -1.7205 -0.9997 3089773 PK04_094194 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2ccc3OCOc3c2)[C@H](OC(=O)Nc4ccc5OCOc5c4)[C@@H]1OC(=O)Nc6ccc7OCOc7c6 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 J17 compound treatment 212320.0 -319000.0 -1.59 229650.0 -212000.0 -1.0 -1.8308 -0.9746 3186732 PK04_094195 CN1C(=O)[C@]2(CCS(=O)(=O)c3ccccc3)N=C(O[C@@H]2c4ccccc14)c5ccc(OCCCO)cc5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 J18 compound treatment 198170.0 -333000.0 -1.66 166890.0 -275000.0 -1.29 -2.0895 -0.9922 3089774 PK04_094196 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2ccccc2c3ccccc3)[C@H](OC(=O)Nc4ccc5OCOc5c4)[C@@H]1OC(=O)Nc6ccc7OCOc7c6 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 J19 compound treatment 337220.0 -194000.0 -0.97 239480.0 -202000.0 -0.95 -1.357 -1.0 3186733 PK04_094197 CCCN1C(=O)[C@@]2(Cc3ccccc13)N=C(O[C@H]2c4ccccc4)c5ccc(OCCCO)cc5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 J20 compound treatment 351410.0 -180000.0 -0.9 329660.0 -112000.0 -0.53 -1.0069 -0.9677 3089775 PK04_094198 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2ccc(Oc3ccccc3)cc2)[C@H](OC(=O)Nc4ccc5OCOc5c4)[C@@H]1OC(=O)Nc6ccc7OCOc7c6 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 J21 mock treatment 479700.0 -51400.0 -0.26 463650.0 22100.0 0.1 -0.1082 -0.3907 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 J22 mock treatment 505950.0 -25200.0 -0.13 473780.0 32200.0 0.15 0.0182 0.0924 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 J23 compound treatment 487720.0 -43400.0 -0.22 259260.0 -182000.0 -0.86 -0.7597 -0.8588 3068619 PK04_094199 COC(=O)C1ON(C(=N1)c2ccc(OCCCO)cc2)c3ccccc3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 J24 compound treatment 246790.0 -284000.0 -1.42 204120.0 -237000.0 -1.12 -1.794 -0.9929 3089828 PK04_094200 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2ccccc2)[C@H](OC(=O)Nc3ccccc3c4ccccc4)[C@@H]1OC(=O)Nc5ccccc5c6ccccc6 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 K01 compound treatment 304330.0 -227000.0 -1.13 173520.0 -268000.0 -1.26 -1.6925 -0.9986 3068620 PK04_094201 COCCCNC(=O)[C@]1(Cc2ccccc2CN=[N+]=[N-])N=C(O[C@@H]1c3ccccc3)c4ccc(OCCCO)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 K02 compound treatment 177870.0 -353000.0 -1.76 492160.0 50600.0 0.24 -1.0793 -0.6063 3186736 PK04_094202 OCCCOc1ccc(cc1)C2=N[C@@](CC=C)([C@@H](O2)c3ccccc3CN=[N+]=[N-])C(=O)N4CCCCC4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 K03 compound treatment 154010.0 -377000.0 -1.88 427360.0 -14200.0 -0.07 -1.3791 -0.7318 3186737 PK04_094203 CN(C)C(=O)[C@]1(Cc2ccccc2)N=C(O[C@@H]1c3ccccc3CN=[N+]=[N-])c4ccc(OCCCO)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 K04 compound treatment 616000.0 84900.0 0.42 539040.0 97500.0 0.46 0.6239 0.9992 3068660 PK04_094204 CN(C)C(=O)[C@@]1(CCC(=O)OC(C)(C)C)N=C(O[C@H]1c2ccccc2CN=[N+]=[N-])c3ccc(OCCCO)cc3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 K05 compound treatment 226490.0 -305000.0 -1.52 329440.0 -112000.0 -0.53 -1.4488 -0.8997 3186738 PK04_094205 OCCCOc1ccc(cc1)C2=N[C@@](CCS(=O)(=O)c3ccccc3)([C@@H](O2)c4ccccc4N=[N+]=[N-])C(=O)NCC(O)CO 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 K06 compound treatment 606600.0 75500.0 0.38 357240.0 -84300.0 -0.4 -0.014 -0.0255 3068661 PK04_094206 OCCCOc1ccc(cc1)C2=N[C@](CCS(=O)(=O)c3ccccc3)(CO2)C(=O)N4CCOCC4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 K07 mock treatment 675590.0 144000.0 0.72 450110.0 8530.0 0.04 0.5386 0.7453 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 K08 mock treatment 496320.0 -34800.0 -0.17 237990.0 -204000.0 -0.96 -0.8001 -0.822 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 K09 compound treatment 310270.0 -221000.0 -1.1 410000.0 -31600.0 -0.15 -0.885 -0.7952 3186739 PK04_094207 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3CN=[N+]=[N-])([C@H](O2)c4ccccc4CN=[N+]=[N-])C(=O)NCc5ccccc5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 K10 compound treatment 651930.0 121000.0 0.6 340750.0 -101000.0 -0.47 0.0913 0.1189 3186740 PK04_094208 OCCCOc1ccc(cc1)C2=N[C@@](CC=C)([C@@H](O2)c3ccccc3CN=[N+]=[N-])C(=O)NCC(O)CO 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 K11 compound treatment 225310.0 -306000.0 -1.53 389700.0 -51900.0 -0.24 -1.2526 -0.8098 3068664 PK04_094209 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3CN=[N+]=[N-])([C@H](O2)c4ccccc4CN=[N+]=[N-])C(=O)N5CCCCC5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 K12 compound treatment 441870.0 -89300.0 -0.45 241230.0 -200000.0 -0.94 -0.9816 -0.9416 3186741 PK04_094210 COCCCNC(=O)[C@@]1(Cc2ccccc2)N=C(O[C@H]1c3ccccc3CN=[N+]=[N-])c4ccc(OCCCO)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 K13 compound treatment 388160.0 -143000.0 -0.71 203480.0 -238000.0 -1.12 -1.2968 -0.9764 3068666 PK04_094211 CN(C)C(=O)[C@@]1(CCS(=O)(=O)c2ccccc2)N=C(O[C@H]1c3ccccc3N=[N+]=[N-])c4ccc(OCCCO)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 K14 compound treatment 358950.0 -172000.0 -0.86 337280.0 -104000.0 -0.49 -0.955 -0.9646 3186742 PK04_094212 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3CN=[N+]=[N-])(CO2)C(=O)NCc4ccccc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 K15 mock treatment 687780.0 157000.0 0.78 541700.0 100000.0 0.47 0.8862 0.9705 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 K16 mock treatment 645380.0 114000.0 0.57 504910.0 63300.0 0.3 0.6141 0.954 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 K17 compound treatment 591420.0 60300.0 0.3 180730.0 -261000.0 -1.23 -0.6546 -0.5182 3186743 PK04_094213 OCCCOc1ccc(cc1)C2=N[C@@](Cc3ccccc3N=[N+]=[N-])([C@@H](O2)c4ccccc4CN=[N+]=[N-])C(=O)NCCN5CCOCC5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 K18 compound treatment 525810.0 -5310.0 -0.03 237120.0 -204000.0 -0.96 -0.6988 -0.7263 3068667 PK04_094214 OCCCOc1ccc(cc1)C2=N[C@@](Cc3ccccc3CN=[N+]=[N-])([C@@H](O2)c4ccccc4N=[N+]=[N-])C(=O)NCc5ccccc5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 K19 compound treatment 554760.0 23600.0 0.12 338040.0 -104000.0 -0.49 -0.2609 -0.5206 3186744 PK04_094215 CC(C)(C)OC(=O)CC[C@@]1(N=C(O[C@H]1c2ccccc2N=[N+]=[N-])c3ccc(OCCCO)cc3)C(=O)N4CCOCC4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 K20 compound treatment 558400.0 27300.0 0.14 233930.0 -208000.0 -0.98 -0.5943 -0.6026 3186745 PK04_094216 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3)([C@H](O2)c4ccccc4CN=[N+]=[N-])C(=O)NCc5ccccc5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 K21 compound treatment 206610.0 -325000.0 -1.62 158490.0 -283000.0 -1.33 -2.0876 -0.9952 3068668 PK04_094217 OCCCOc1ccc(cc1)C2=N[C@](CC=C)([C@H](O2)c3ccccc3)C(=O)N4CCCCC4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 K22 compound treatment 324590.0 -207000.0 -1.03 212770.0 -229000.0 -1.08 -1.4904 -0.9998 3186746 PK04_094218 CN(C)C(=O)[C@@]1(Cc2ccccc2)N=C(O[C@H]1c3ccccc3)c4ccc(OCCCO)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 K23 mock treatment 488640.0 -42500.0 -0.21 457010.0 15400.0 0.07 -0.0987 -0.4403 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 K24 mock treatment 582110.0 51000.0 0.25 334160.0 -107000.0 -0.51 -0.1772 -0.3132 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 L01 compound treatment 259170.0 -272000.0 -1.36 365920.0 -75700.0 -0.36 -1.2121 -0.8632 3068669 PK04_094219 CCOC(=O)N1C(N=C(N1C(=O)OCC)c2ccc(OCCCO)cc2)C(=O)OC 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 L02 compound treatment 176360.0 -355000.0 -1.77 216110.0 -225000.0 -1.06 -2.0028 -0.9699 3001020 PK04_094220 CCc1cccc(NC(=O)O[C@@H]2[C@@H](CO)O[C@H](OC)[C@@H](OC(=O)Nc3ccccc3c4ccccc4)[C@H]2OC(=O)Nc5ccccc5c6ccccc6)c1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 L03 compound treatment 380640.0 -150000.0 -0.75 134200.0 -307000.0 -1.45 -1.5538 -0.9535 3068670 PK04_094221 COCCCNC(=O)C1ON(C(=N1)c2ccc(OCCCO)cc2)c3ccccc3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 L04 compound treatment 173480.0 -358000.0 -1.79 226740.0 -215000.0 -1.01 -1.9776 -0.9636 3089829 PK04_094222 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2cccc(F)c2)[C@H](OC(=O)Nc3ccccc3c4ccccc4)[C@@H]1OC(=O)Nc5ccccc5c6ccccc6 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 L05 compound treatment 584880.0 53800.0 0.27 204500.0 -237000.0 -1.12 -0.5987 -0.5219 3186813 PK04_094223 OCCCOc1ccc(cc1)C2=NC(ON2c3ccccc3)C(=O)O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 L06 compound treatment 291860.0 -239000.0 -1.19 188000.0 -254000.0 -1.19 -1.6884 -1.0 3001022 PK04_094224 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2ccc(OC)cc2)[C@H](OC(=O)Nc3ccccc3c4ccccc4)[C@@H]1OC(=O)Nc5ccccc5c6ccccc6 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 L07 mock treatment 534730.0 3610.0 0.02 506250.0 64700.0 0.3 0.2278 0.7477 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 L08 mock treatment 628010.0 96900.0 0.48 530450.0 88900.0 0.42 0.6377 0.9973 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 L09 compound treatment 609090.0 78000.0 0.39 468210.0 26600.0 0.13 0.3639 0.8896 3067926 PK04_094225 COC(=O)[C@]1(CO)N=C(O[C@@H]1c2ccccc2N=[N+]=[N-])c3ccc(OCCCO)cc3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 L10 compound treatment 246800.0 -284000.0 -1.42 198880.0 -243000.0 -1.14 -1.8114 -0.9941 3089768 PK04_094226 CCOC(=O)c1ccc(NC(=O)O[C@@H]2[C@@H](CO)O[C@H](OC)[C@@H](OC(=O)Nc3ccccc3)[C@H]2OC(=O)Nc4ccccc4)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 L11 compound treatment 564390.0 33300.0 0.17 414480.0 -27100.0 -0.13 0.0273 0.1306 3186815 PK04_094227 COC(=O)[C@]1(CO)N=C(O[C@@H]1c2ccccc2CN=[N+]=[N-])c3ccc(OCCCO)cc3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 L12 compound treatment 267070.0 -264000.0 -1.32 212650.0 -229000.0 -1.08 -1.694 -0.9949 3089830 PK04_094228 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2ccc(cc2)C(F)(F)F)[C@H](OC(=O)Nc3ccccc3c4ccccc4)[C@@H]1OC(=O)Nc5ccccc5c6ccccc6 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 L13 compound treatment 615730.0 84600.0 0.42 420050.0 -21500.0 -0.1 0.2272 0.5228 3067927 PK04_094229 OCCCOc1ccc(cc1)C2=NC(ON2c3ccccc3)C(=O)NCC(O)CO 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 L14 compound treatment 216510.0 -315000.0 -1.57 158050.0 -284000.0 -1.33 -2.0541 -0.9967 3089831 PK04_094230 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2c(C)cccc2OC)[C@H](OC(=O)Nc3ccccc3c4ccccc4)[C@@H]1OC(=O)Nc5ccccc5c6ccccc6 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 L15 mock treatment 549660.0 18500.0 0.09 436590.0 -4990.0 -0.02 0.0489 0.5115 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 L16 mock treatment 496320.0 -34800.0 -0.17 508890.0 67300.0 0.32 0.101 0.2795 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 L17 compound treatment 259220.0 -272000.0 -1.36 224010.0 -218000.0 -1.02 -1.6839 -0.9903 3067928 PK04_094231 OCCCOc1ccc(cc1)C2=NC(ON2c3ccccc3)C(=O)NCc4ccccc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 L18 compound treatment 317880.0 -213000.0 -1.07 224850.0 -217000.0 -1.02 -1.4739 -0.9998 3001180 PK04_094232 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2ccc3OCOc3c2)[C@H](OC(=O)Nc4ccccc4c5ccccc5)[C@@H]1OC(=O)Nc6ccccc6c7ccccc7 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 L19 compound treatment 521620.0 -9500.0 -0.05 256960.0 -185000.0 -0.87 -0.6476 -0.7446 3067929 PK04_094233 OCCCOc1ccc(cc1)C2=NC(ON2c3ccccc3)C(=O)NCCN4CCOCC4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 L20 compound treatment 263290.0 -268000.0 -1.34 209930.0 -232000.0 -1.09 -1.7164 -0.9948 3001092 PK04_094234 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2ccccc2c3ccccc3)[C@H](OC(=O)Nc4ccccc4c5ccccc5)[C@@H]1OC(=O)Nc6ccccc6c7ccccc7 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 L21 compound treatment 583520.0 52400.0 0.26 368640.0 -72900.0 -0.34 -0.0576 -0.1334 3067930 PK04_094235 OCCCOc1ccc(cc1)C2=NC(ON2c3ccccc3)C(=O)N4CCCCC4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 L22 compound treatment 235920.0 -295000.0 -1.47 413480.0 -28100.0 -0.13 -1.136 -0.7674 3001093 PK04_094236 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2ccc(Oc3ccccc3)cc2)[C@H](OC(=O)Nc4ccccc4c5ccccc5)[C@@H]1OC(=O)Nc6ccccc6c7ccccc7 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 L23 mock treatment 502250.0 -28900.0 -0.14 548210.0 107000.0 0.5 0.2527 0.4842 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 L24 mock treatment 523890.0 -7230.0 -0.04 337610.0 -104000.0 -0.49 -0.3714 -0.7573 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 M01 compound treatment 131930.0 -399000.0 -1.99 198020.0 -244000.0 -1.15 -2.2199 -0.9654 3067931 PK04_094237 OCCCOc1ccc(cc1)C2=N[C@@](Cc3ccccc3CN=[N+]=[N-])([C@@H](O2)c4ccccc4)C(=O)N5CCOCC5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 M02 compound treatment 136210.0 -395000.0 -1.97 166150.0 -275000.0 -1.3 -2.3108 -0.9792 3186821 PK04_094238 COCCCNC(=O)[C@]1(CC=C)N=C(O[C@@H]1c2ccccc2N=[N+]=[N-])c3ccc(OCCCO)cc3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 M03 compound treatment 168190.0 -363000.0 -1.81 182400.0 -259000.0 -1.22 -2.1438 -0.9814 3067933 PK04_094239 NC(=O)[C@@]1(Cc2ccccc2CN=[N+]=[N-])N=C(O[C@H]1c3ccccc3)c4ccc(OCCCO)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 M04 compound treatment 679480.0 148000.0 0.74 454490.0 12900.0 0.06 0.5669 0.7625 3186822 PK04_094240 CC(C)(C)OC(=O)CC[C@@]1(COC(=N1)c2ccc(OCCCO)cc2)C(=O)NCCN3CCOCC3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 M05 compound treatment 594480.0 63400.0 0.32 166880.0 -275000.0 -1.29 -0.6899 -0.5186 3067934 PK04_094241 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3)(CO2)C(=O)NCCN4CCOCC4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 M06 compound treatment 601140.0 70000.0 0.35 293200.0 -148000.0 -0.7 -0.2462 -0.3154 3186823 PK04_094242 CC(C)(C)OC(=O)CC[C@@]1(N=C(O[C@H]1c2ccccc2N=[N+]=[N-])c3ccc(OCCCO)cc3)C(=O)N 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 M07 compound treatment 153050.0 -378000.0 -1.89 128420.0 -313000.0 -1.47 -2.3768 -0.9925 3186824 PK04_094243 CN(C)C(=O)[C@]1(Cc2ccccc2)N=C(O[C@@H]1c3ccccc3N=[N+]=[N-])c4ccc(OCCCO)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 M08 compound treatment 279620.0 -252000.0 -1.26 179690.0 -262000.0 -1.23 -1.7593 -1.0 3186825 PK04_094244 OCCCOc1ccc(cc1)C2=N[C@@](Cc3ccccc3N=[N+]=[N-])([C@@H](O2)c4ccccc4N=[N+]=[N-])C(=O)NCC(O)CO 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 M09 mock treatment 638690.0 108000.0 0.54 513830.0 72200.0 0.34 0.6202 0.9756 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 M10 mock treatment 616990.0 85900.0 0.43 473670.0 32100.0 0.15 0.41 0.9017 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 M11 compound treatment 199940.0 -331000.0 -1.65 271600.0 -170000.0 -0.8 -1.735 -0.9444 3067981 PK04_094245 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3CN=[N+]=[N-])([C@H](O2)c4ccccc4)C(=O)N5CCCCC5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 M12 compound treatment 564880.0 33800.0 0.17 494140.0 52600.0 0.25 0.294 0.9826 3186826 PK04_094246 NC(=O)[C@@]1(CCS(=O)(=O)c2ccccc2)COC(=N1)c3ccc(OCCCO)cc3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 M13 mock treatment 503870.0 -27300.0 -0.14 492520.0 50900.0 0.24 0.0732 0.2655 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 M14 mock treatment 590290.0 59200.0 0.3 478580.0 37000.0 0.17 0.332 0.9681 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 M15 compound treatment 268960.0 -262000.0 -1.31 257710.0 -184000.0 -0.86 -1.5374 -0.9797 3067982 PK04_094247 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3N=[N+]=[N-])(CO2)C(=O)NCc4ccccc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 M16 compound treatment 430150.0 -101000.0 -0.5 164020.0 -278000.0 -1.31 -1.2798 -0.9144 3186827 PK04_094248 OCCCOc1ccc(cc1)C2=N[C@@](Cc3ccccc3)([C@@H](O2)c4ccccc4N=[N+]=[N-])C(=O)N5CCCCC5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 M17 compound treatment 318080.0 -213000.0 -1.06 220640.0 -221000.0 -1.04 -1.4872 -0.9999 3067983 PK04_094249 CN(C)C(=O)[C@]1(Cc2ccccc2)N=C(O[C@@H]1c3ccccc3)c4ccc(OCCCO)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 M18 compound treatment 414810.0 -116000.0 -0.58 428560.0 -13000.0 -0.06 -0.4541 -0.7774 3186828 PK04_094250 NC(=O)[C@]1(Cc2ccccc2CN=[N+]=[N-])N=C(O[C@@H]1c3ccccc3CN=[N+]=[N-])c4ccc(OCCCO)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 M19 compound treatment 273830.0 -257000.0 -1.29 248290.0 -193000.0 -0.91 -1.5516 -0.9856 3186829 PK04_094251 CN(C)C(=O)[C@]1(CC=C)N=C(O[C@@H]1c2ccccc2CN=[N+]=[N-])c3ccc(OCCCO)cc3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 M20 compound treatment 353250.0 -178000.0 -0.89 326180.0 -115000.0 -0.54 -1.012 -0.9721 3067984 PK04_094252 NC(=O)[C@@]1(Cc2ccccc2)N=C(O[C@H]1c3ccccc3N=[N+]=[N-])c4ccc(OCCCO)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 M21 compound treatment 283080.0 -248000.0 -1.24 281600.0 -160000.0 -0.75 -1.4081 -0.9714 3186907 PK04_094253 OCCCOc1ccc(cc1)C2=N[C@](CCS(=O)(=O)c3ccccc3)([C@H](O2)c4ccccc4CN=[N+]=[N-])C(=O)NCc5ccccc5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 M22 compound treatment 366240.0 -165000.0 -0.82 261450.0 -180000.0 -0.85 -1.1814 -0.9999 3067985 PK04_094254 OCCCOc1ccc(cc1)C2=N[C@@](Cc3ccccc3)([C@@H](O2)c4ccccc4CN=[N+]=[N-])C(=O)N5CCCCC5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 M23 compound treatment 213250.0 -318000.0 -1.59 413730.0 -27900.0 -0.13 -1.2153 -0.7629 3186908 PK04_094255 OCCCOc1ccc(cc1)C2=N[C@@](Cc3ccccc3N=[N+]=[N-])([C@@H](O2)c4ccccc4)C(=O)N5CCOCC5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 M24 compound treatment 265180.0 -266000.0 -1.33 176200.0 -265000.0 -1.25 -1.8219 -0.9995 3186909 PK04_094256 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3N=[N+]=[N-])([C@H](O2)c4ccccc4N=[N+]=[N-])C(=O)N5CCOCC5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 N01 compound treatment 467200.0 -63900.0 -0.32 478590.0 37000.0 0.17 -0.1027 -0.2823 3067986 PK04_094257 OCCCOc1ccc(cc1)C2=NC(ON2c3ccccc3)C(=O)N4CCOCC4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 N02 compound treatment 553210.0 22100.0 0.11 550970.0 109000.0 0.51 0.4418 0.8396 3186910 PK04_094258 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)CCc2ccccc2)[C@@H]3OC(=O)[C@@H](Cc4ccccc4)C/C=C/C[C@H](Cc5ccccc5)C(=O)O[C@@H]13 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 N03 compound treatment 526730.0 -4390.0 -0.02 367520.0 -74100.0 -0.35 -0.2618 -0.7501 3067987 PK04_094259 CN(C)C(=O)C1ON(C(=N1)c2ccc(OCCCO)cc2)c3ccccc3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 N04 compound treatment 507810.0 -23300.0 -0.12 456580.0 15000.0 0.07 -0.0325 -0.2384 3186911 PK04_094260 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)c2ccc(Br)cc2)[C@@H]3OC(=O)[C@@H](Cc4ccccc4)C/C=C/C[C@H](Cc5ccccc5)C(=O)O[C@@H]13 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 N05 compound treatment 421770.0 -109000.0 -0.55 512860.0 71300.0 0.34 -0.1491 -0.2327 3414052 PK04_094261 COC(=O)[C@@H]1N=C(O[C@@H]1C)c2ccc(OCCCO)cc2 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 N06 compound treatment 567850.0 36700.0 0.18 154690.0 -287000.0 -1.35 -0.8245 -0.6054 3186912 PK04_094262 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)c2c(OC)cccc2OC)[C@@H]3OC(=O)[C@@H](Cc4ccccc4)C/C=C/C[C@H](Cc5ccccc5)C(=O)O[C@@H]13 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 N07 compound treatment 589880.0 58800.0 0.29 439800.0 -1780.0 -0.01 0.2016 0.6866 3186913 PK04_094263 OCC(NS(=O)(=O)c1ccc(Br)cc1)C=C 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 N08 compound treatment 505600.0 -25500.0 -0.13 468430.0 26800.0 0.13 -8.0E-4 -0.0047 1952953 PK04_094264 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2ccccc2)[C@@H]3OC(=O)[C@@H](Cc4ccccc4)C/C=C/C[C@H](Cc5ccccc5)C(=O)O[C@@H]13 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 N09 mock treatment 599960.0 68800.0 0.34 496130.0 54500.0 0.26 0.4245 0.9896 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 N10 mock treatment 658450.0 127000.0 0.64 505760.0 64200.0 0.3 0.6631 0.942 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 N11 compound treatment 589080.0 58000.0 0.29 489090.0 47500.0 0.22 0.3627 0.9918 3068027 PK04_094265 CC(=O)OC[C@H](C=C)N(C(=O)OC(C)(C)C)S(=O)(=O)c1ccc(Br)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 N12 compound treatment 340680.0 -190000.0 -0.95 329600.0 -112000.0 -0.53 -1.045 -0.9612 3186914 PK04_094266 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2cccc(F)c2)[C@@H]3OC(=O)[C@@H](Cc4ccccc4)C/C=C/C[C@H](Cc5ccccc5)C(=O)O[C@@H]13 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 N13 mock treatment 555200.0 24100.0 0.12 408080.0 -33500.0 -0.16 -0.0264 -0.1332 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 N14 mock treatment 489280.0 -41800.0 -0.21 269600.0 -172000.0 -0.81 -0.7198 -0.8615 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 N15 compound treatment 536920.0 5800.0 0.03 526780.0 85200.0 0.4 0.3038 0.7562 3068028 PK04_094267 CC(=O)OC[C@@H](NS(=O)(=O)c1ccc(Br)cc1)C=C 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 N16 compound treatment 451840.0 -79300.0 -0.4 517770.0 76200.0 0.36 -0.0266 -0.0498 3186915 PK04_094268 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2ccc(OC)cc2)[C@@H]3OC(=O)[C@@H](Cc4ccccc4)C/C=C/C[C@H](Cc5ccccc5)C(=O)O[C@@H]13 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 N17 compound treatment 551840.0 20700.0 0.1 489330.0 47700.0 0.22 0.232 0.9381 3068029 PK04_094269 CC(=O)OC[C@H](NS(=O)(=O)c1ccc(Br)cc1)C=C 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 N18 compound treatment 367000.0 -164000.0 -0.82 200160.0 -241000.0 -1.14 -1.3826 -0.9872 1952947 PK04_094270 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2ccc3OCOc3c2)[C@@H]4OC(=O)[C@@H](Cc5ccccc5)C/C=C/C[C@H](Cc6ccccc6)C(=O)O[C@@H]14 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 N19 compound treatment 485630.0 -45500.0 -0.23 489040.0 47500.0 0.22 -0.0028 -0.0089 3068030 PK04_094271 OC[C@H](NS(=O)(=O)c1ccc(Br)cc1)C=C 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 N20 compound treatment 150970.0 -380000.0 -1.9 199200.0 -242000.0 -1.14 -2.1487 -0.9702 3186916 PK04_094272 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2ccc(Br)cc2)[C@@H]3OC(=O)[C@@H](Cc4ccccc4)C/C=C/C[C@H](Cc5ccccc5)C(=O)O[C@@H]13 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 N21 compound treatment 526670.0 -4450.0 -0.02 468480.0 26900.0 0.13 0.0737 0.5741 3068031 PK04_094273 CC(=O)OC[C@@H](C=C)N(C(=O)OC(C)(C)C)S(=O)(=O)c1ccc(Br)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 N22 compound treatment 186160.0 -345000.0 -1.72 345870.0 -95700.0 -0.45 -1.5366 -0.8629 1952944 PK04_094274 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2ccc(C#N)cc2)[C@@H]3OC(=O)[C@@H](Cc4ccccc4)C/C=C/C[C@H](Cc5ccccc5)C(=O)O[C@@H]13 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 N23 compound treatment 457240.0 -73900.0 -0.37 220540.0 -221000.0 -1.04 -0.9961 -0.9029 3186917 PK04_094275 CC(=O)OC[C@H](C=C)N(Cc1ccc(cc1)[N+](=O)[O-])S(=O)(=O)c2ccc(Br)cc2 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 N24 compound treatment 387270.0 -144000.0 -0.72 450180.0 8600.0 0.04 -0.4794 -0.6663 3413982 PK04_094276 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)CCc2ccccc2)[C@@H]3OC(=O)[C@H](Cc4ccccc4)C/C=C/C[C@@H](Cc5ccccc5)C(=O)O[C@@H]13 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 O01 compound treatment 88480.0 -443000.0 -2.21 91550.0 -350000.0 -1.65 -2.7275 -0.9895 3068032 PK04_094277 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3)([C@H](O2)c4ccccc4N=[N+]=[N-])C(=O)NCc5ccccc5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 O02 compound treatment 252370.0 -279000.0 -1.39 144200.0 -297000.0 -1.4 -1.9735 -1.0 3186919 PK04_094278 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3)([C@H](O2)c4ccccc4CN=[N+]=[N-])C(=O)N5CCCCC5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 O03 compound treatment 562400.0 31300.0 0.16 494270.0 52700.0 0.25 0.2857 0.9753 3068033 PK04_094279 NC(=O)[C@@]1(CC=C)COC(=N1)c2ccc(OCCCO)cc2 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 O04 compound treatment 495840.0 -35300.0 -0.18 519800.0 78200.0 0.37 0.1355 0.3323 3186920 PK04_094280 OCCCOc1ccc(cc1)C2=N[C@](CC=C)([C@H](O2)c3ccccc3CN=[N+]=[N-])C(=O)NCC(O)CO 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 O05 compound treatment 131070.0 -400000.0 -2.0 106830.0 -335000.0 -1.57 -2.5262 -0.993 3068035 PK04_094281 OCCCOc1ccc(cc1)C2=N[C@@](Cc3ccccc3CN=[N+]=[N-])([C@@H](O2)c4ccccc4)C(=O)N5CCCCC5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 O06 compound treatment 175140.0 -356000.0 -1.78 137140.0 -304000.0 -1.43 -2.2698 -0.9942 3186921 PK04_094282 CN(C)C(=O)[C@@]1(Cc2ccccc2N=[N+]=[N-])COC(=N1)c3ccc(OCCCO)cc3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 O07 compound treatment 175690.0 -355000.0 -1.78 183590.0 -258000.0 -1.21 -2.1133 -0.9828 3186922 PK04_094283 CN(C)C(=O)[C@]1(Cc2ccccc2N=[N+]=[N-])N=C(O[C@@H]1c3ccccc3)c4ccc(OCCCO)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 O08 compound treatment 432560.0 -98600.0 -0.49 410090.0 -31500.0 -0.15 -0.4528 -0.8809 3068037 PK04_094284 CN(C)C(=O)[C@@]1(Cc2ccccc2)COC(=N1)c3ccc(OCCCO)cc3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 O09 compound treatment 225130.0 -306000.0 -1.53 193770.0 -248000.0 -1.17 -1.9049 -0.9911 3186923 PK04_094285 OCCCOc1ccc(cc1)C2=N[C@@](Cc3ccccc3)([C@@H](O2)c4ccccc4CN=[N+]=[N-])C(=O)N5CCOCC5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 O10 compound treatment 195840.0 -335000.0 -1.67 230790.0 -211000.0 -0.99 -1.8852 -0.9687 3068038 PK04_094286 OCCCOc1ccc(cc1)C2=N[C@@](Cc3ccccc3N=[N+]=[N-])([C@@H](O2)c4ccccc4)C(=O)N5CCCCC5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 O11 mock treatment 602530.0 71400.0 0.36 466000.0 24400.0 0.11 0.3334 0.8898 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 O12 mock treatment 284840.0 -246000.0 -1.23 219850.0 -222000.0 -1.04 -1.6073 -0.9966 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 O13 compound treatment 478440.0 -52700.0 -0.26 388720.0 -52900.0 -0.25 -0.3619 -0.9996 3186924 PK04_094287 CC(C)(C)OC(=O)CC[C@@]1(N=C(O[C@H]1c2ccccc2)c3ccc(OCCCO)cc3)C(=O)N4CCOCC4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 O14 compound treatment 367730.0 -163000.0 -0.82 252870.0 -189000.0 -0.89 -1.2047 -0.9991 3186925 PK04_094288 CC(C)(C)OC(=O)CC[C@@]1(N=C(O[C@H]1c2ccccc2CN=[N+]=[N-])c3ccc(OCCCO)cc3)C(=O)NCc4ccccc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 O15 compound treatment 617700.0 86600.0 0.43 502510.0 60900.0 0.29 0.5084 0.98 3187013 PK04_094289 CC(C)(C)OC(=O)CC[C@]1(N=C(O[C@@H]1c2ccccc2N=[N+]=[N-])c3ccc(OCCCO)cc3)C(=O)N 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 O16 compound treatment 251600.0 -280000.0 -1.4 232030.0 -210000.0 -0.99 -1.6841 -0.9855 3068077 PK04_094290 OCCCOc1ccc(cc1)C2=N[C@@](CC=C)([C@@H](O2)c3ccccc3CN=[N+]=[N-])C(=O)N4CCOCC4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 O17 compound treatment 248640.0 -282000.0 -1.41 232900.0 -209000.0 -0.98 -1.6917 -0.9843 3187014 PK04_094291 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3N=[N+]=[N-])([C@H](O2)c4ccccc4)C(=O)NCC(O)CO 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 O18 compound treatment 329970.0 -201000.0 -1.0 179850.0 -262000.0 -1.23 -1.5809 -0.9949 3187015 PK04_094292 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3N=[N+]=[N-])([C@H](O2)c4ccccc4)C(=O)N5CCOCC5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 O19 compound treatment 307000.0 -224000.0 -1.12 227400.0 -214000.0 -1.01 -1.5039 -0.9986 3068081 PK04_094293 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3N=[N+]=[N-])(CO2)C(=O)NCCN4CCOCC4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 O20 compound treatment 251040.0 -280000.0 -1.4 214240.0 -227000.0 -1.07 -1.7453 -0.9912 3187016 PK04_094294 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3CN=[N+]=[N-])(CO2)C(=O)N4CCCCC4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 O21 compound treatment 330280.0 -201000.0 -1.0 329120.0 -112000.0 -0.53 -1.0834 -0.9553 3187017 PK04_094295 COCCCNC(=O)[C@@]1(CCS(=O)(=O)c2ccccc2)N=C(O[C@H]1c3ccccc3)c4ccc(OCCCO)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 O22 compound treatment 139160.0 -392000.0 -1.96 146660.0 -295000.0 -1.39 -2.3652 -0.9858 3068083 PK04_094296 COCCCNC(=O)[C@@]1(Cc2ccccc2CN=[N+]=[N-])N=C(O[C@H]1c3ccccc3N=[N+]=[N-])c4ccc(OCCCO)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 O23 compound treatment 236220.0 -295000.0 -1.47 162590.0 -279000.0 -1.31 -1.9694 -0.9983 3187018 PK04_094297 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3N=[N+]=[N-])([C@H](O2)c4ccccc4)C(=O)N5CCCCC5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 O24 compound treatment 174400.0 -357000.0 -1.78 348990.0 -92600.0 -0.44 -1.5678 -0.8548 3068084 PK04_094298 OCCCOc1ccc(cc1)C2=N[C@](CC=C)([C@H](O2)c3ccccc3)C(=O)NCc4ccccc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 P01 compound treatment 180210.0 -351000.0 -1.75 157090.0 -284000.0 -1.34 -2.1855 -0.9911 3187019 PK04_094299 CC(=O)OC[C@H](C=C)N(Cc1ccccc1[N+](=O)[O-])S(=O)(=O)c2ccc(Br)cc2 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 P02 compound treatment 222340.0 -309000.0 -1.54 201490.0 -240000.0 -1.13 -1.8891 -0.9883 3413984 PK04_094300 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)c2ccc(Br)cc2)[C@@H]3OC(=O)[C@H](Cc4ccccc4)C/C=C/C[C@@H](Cc5ccccc5)C(=O)O[C@@H]13 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 P03 compound treatment 151680.0 -379000.0 -1.9 152340.0 -289000.0 -1.36 -2.3021 -0.9868 3068086 PK04_094301 COc1ccc(CN([C@H](CO)C=C)S(=O)(=O)c2ccc(Br)cc2)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 P04 compound treatment 149310.0 -382000.0 -1.91 140930.0 -301000.0 -1.41 -2.3484 -0.9892 3413986 PK04_094302 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)c2c(OC)cccc2OC)[C@@H]3OC(=O)[C@H](Cc4ccccc4)C/C=C/C[C@@H](Cc5ccccc5)C(=O)O[C@@H]13 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 P05 compound treatment 390810.0 -140000.0 -0.7 223200.0 -218000.0 -1.03 -1.2219 -0.9826 3068087 PK04_094303 COc1cc(CN([C@@H](COC(=O)C)C=C)S(=O)(=O)c2ccc(Br)cc2)ccc1OC(=O)C 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 P06 compound treatment 193630.0 -337000.0 -1.69 128690.0 -313000.0 -1.47 -2.2326 -0.9977 1952975 PK04_094304 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2ccccc2)[C@@H]3OC(=O)[C@H](Cc4ccccc4)C/C=C/C[C@@H](Cc5ccccc5)C(=O)O[C@@H]13 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 P07 compound treatment 469490.0 -61600.0 -0.31 196220.0 -245000.0 -1.15 -1.0337 -0.8654 3068088 PK04_094305 OCCCNS(=O)(=O)c1ccc(Br)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 P08 compound treatment 268040.0 -263000.0 -1.31 133680.0 -308000.0 -1.45 -1.9532 -0.9988 3413993 PK04_094306 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2ccc(OC)cc2)[C@@H]3OC(=O)[C@H](Cc4ccccc4)C/C=C/C[C@@H](Cc5ccccc5)C(=O)O[C@@H]13 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 P09 compound treatment 249730.0 -281000.0 -1.41 248830.0 -193000.0 -0.91 -1.6349 -0.9775 3068089 PK04_094307 CC[Si](CC)(CC)OC[C@@H](C=C)N(Cc1ccc(OC(=O)C)c(OC)c1)S(=O)(=O)c2ccc(Br)cc2 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 P10 compound treatment 141520.0 -390000.0 -1.95 216740.0 -225000.0 -1.06 -2.1238 -0.9589 1952969 PK04_094308 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2ccc3OCOc3c2)[C@@H]4OC(=O)[C@H](Cc5ccccc5)C/C=C/C[C@@H](Cc6ccccc6)C(=O)O[C@@H]14 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 P11 mock treatment 413870.0 -117000.0 -0.59 418490.0 -23100.0 -0.11 -0.4909 -0.8242 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 P12 mock treatment 185700.0 -345000.0 -1.73 409400.0 -32200.0 -0.15 -1.327 -0.7662 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 P13 compound treatment 254280.0 -277000.0 -1.38 248260.0 -193000.0 -0.91 -1.6207 -0.9793 3068090 PK04_094309 COc1cc(CO)ccc1OC(=O)C 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 P14 compound treatment 156520.0 -375000.0 -1.87 286300.0 -155000.0 -0.73 -1.8394 -0.9158 3068091 PK04_094310 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)CCc2ccccc2)[C@@H]3OC(=O)[C@@H](Cc4ccc5ccccc5c4)C/C=C/C[C@H](Cc6ccc7ccccc7c6)C(=O)O[C@@H]13 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 P15 compound treatment 206780.0 -324000.0 -1.62 206120.0 -235000.0 -1.11 -1.9286 -0.9828 3187025 PK04_094311 COc1ccc(CN(C2=CC[C@@]3(C(=O)N)C(=O)C(=C(Cl)C(=O)[C@]3(C2)C#N)Cl)S(=O)(=O)c4ccc(Br)cc4)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 P16 compound treatment 344990.0 -186000.0 -0.93 247200.0 -194000.0 -0.91 -1.3039 -1.0 3187026 PK04_094312 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)c2ccc(Br)cc2)[C@@H]3OC(=O)[C@@H](Cc4ccc5ccccc5c4)C/C=C/C[C@H](Cc6ccc7ccccc7c6)C(=O)O[C@@H]13 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 P17 compound treatment 230960.0 -300000.0 -1.5 357180.0 -84400.0 -0.4 -1.3408 -0.8646 3068092 PK04_094313 CC(C)(C)OC(=O)N1[C@H](COC1(C)C)C=C(Br)Br 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 P18 compound treatment 147210.0 -384000.0 -1.92 247910.0 -194000.0 -0.91 -2.0 -0.9421 3187027 PK04_094314 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)c2c(OC)cccc2OC)[C@@H]3OC(=O)[C@@H](Cc4ccc5ccccc5c4)C/C=C/C[C@H](Cc6ccc7ccccc7c6)C(=O)O[C@@H]13 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 P19 compound treatment 238120.0 -293000.0 -1.46 167960.0 -274000.0 -1.29 -1.9448 -0.998 1003211 PK04_094315 CNS(=O)(=O)c1ccc(C)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 P20 compound treatment 324480.0 -207000.0 -1.03 250400.0 -191000.0 -0.9 -1.3657 -0.9976 3187028 PK04_094316 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2ccccc2)[C@@H]3OC(=O)[C@@H](Cc4ccc5ccccc5c4)C/C=C/C[C@H](Cc6ccc7ccccc7c6)C(=O)O[C@@H]13 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 P21 compound treatment 185630.0 -345000.0 -1.73 151240.0 -290000.0 -1.37 -2.1858 -0.9933 3068127 PK04_094317 COc1cc(COC(=O)C)ccc1OC(=O)C 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 P22 compound treatment 302960.0 -228000.0 -1.14 148370.0 -293000.0 -1.38 -1.781 -0.9955 3187029 PK04_094318 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2ccc(OC)cc2)[C@@H]3OC(=O)[C@@H](Cc4ccc5ccccc5c4)C/C=C/C[C@H](Cc6ccc7ccccc7c6)C(=O)O[C@@H]13 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 P23 compound treatment 429500.0 -102000.0 -0.51 376280.0 -65300.0 -0.31 -0.5761 -0.9711 3068129 PK04_094319 OC[C@@H](NS(=O)(=O)c1ccc(Br)cc1)C=C 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2094 P24 compound treatment 392820.0 -138000.0 -0.69 367230.0 -74400.0 -0.35 -0.7357 -0.9503 3413981 PK04_094320 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)CCc2ccccc2)[C@@H]3OC(=O)[C@H](Cc4cccc(Br)c4)C/C=C/C[C@@H](Cc5cccc(Br)c5)C(=O)O[C@@H]13 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 A01 compound treatment 390000.0 -93900.0 -0.47 442240.0 48700.0 0.23 -0.1696 -0.325 3067957 PK04_095001 OCc1ccc(cc1)[C@H]2N(C3CCCCC3)C(=O)C[C@@]2(C(=O)NC4CC4)c5ccc(cc5)[N+](=O)[O-] 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 A02 compound treatment 467440.0 -16500.0 -0.08 177490.0 -216000.0 -1.02 -0.7767 -0.7618 3187176 PK04_095002 COCCCNC(=O)[C@H]1[C@@H](N(Cc2ccccc2OC)C(=O)c3ccccc13)c4ccc(CO)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 A03 compound treatment 158740.0 -325000.0 -1.62 175230.0 -218000.0 -1.03 -1.8744 -0.9756 3067577 PK04_095003 OCc1ccc([C@H]2N(CC3(CC4CC5CC(C4)C3)C5)C(=O)C[C@@]2(C(=O)NCc6ccccc6)c7ccc(cc7)[N+](=O)[O-])c(I)c1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 A04 compound treatment 168640.0 -315000.0 -1.57 247640.0 -146000.0 -0.69 -1.5986 -0.9307 3187436 PK04_095004 COc1ccc(CCNC(=O)[C@]2(C)[C@@H](N(Cc3ccccc3)C(=O)c4ccccc42)c5ccc(CO)cc5)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 A05 compound treatment 165650.0 -318000.0 -1.59 149210.0 -244000.0 -1.15 -1.9366 -0.9873 3186425 PK04_095005 COc1ccc(CCNC(=O)[C@]2(CC(=O)N(CC3(CC4CC5CC(C4)C3)C5)[C@@H]2c6ccc(CO)cc6I)c7ccc(cc7)[N+](=O)[O-])cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 A06 compound treatment 517810.0 33900.0 0.17 169360.0 -224000.0 -1.05 -0.6258 -0.586 3187069 PK04_095006 OCc1ccc(cc1)[C@H]2[C@H](C(=O)NCc3ccccc3)c4ccccc4C(=O)N2Cc5ccccc5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 A07 compound treatment 200640.0 -283000.0 -1.41 213890.0 -180000.0 -0.84 -1.5979 -0.9697 3187427 PK04_095007 CCCNC(=O)[C@]1(C)[C@@H](N(Cc2cc(cc(c2)C(F)(F)F)C(F)(F)F)C(=O)c3ccccc31)c4ccc(CO)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 A08 compound treatment 112020.0 -372000.0 -1.86 128490.0 -265000.0 -1.25 -2.1949 -0.9812 3187515 PK04_095008 COc1ccc(CCNC(=O)[C@]2(CC(=O)N(CC3(CC4CC5CC(C4)C3)C5)[C@@H]2c6ccc(CO)cc6)c7ccc(cc7)[N+](=O)[O-])cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 A09 compound treatment 470240.0 -13700.0 -0.07 208800.0 -185000.0 -0.87 -0.6627 -0.7603 3187425 PK04_095009 C[C@]1([C@@H](N(Cc2cc(F)cc(c2)C(F)(F)F)C(=O)c3ccccc31)c4ccc(CO)cc4)C(=O)NCC(F)(F)F 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 A10 compound treatment 162580.0 -321000.0 -1.6 429650.0 36100.0 0.17 -1.0147 -0.6287 3068592 PK04_095010 CCCNC(=O)[C@]1(C)[C@@H](N(C(C)C)C(=O)c2ccccc21)c3ccc(CO)cc3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 A11 compound treatment 164450.0 -319000.0 -1.6 129300.0 -264000.0 -1.24 -2.007 -0.9924 3187517 PK04_095011 OCc1ccc(cc1)[C@H]2N(CC3(CC4CC5CC(C4)C3)C5)C(=O)C[C@@]2(C(=O)NCC(F)(F)F)c6ccc(cc6)[N+](=O)[O-] 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 A12 compound treatment 152170.0 -332000.0 -1.66 388270.0 -5260.0 -0.02 -1.1891 -0.7176 3187344 PK04_095012 COCCCNC(=O)[C@H]1[C@@H](N(CC2(CC3CC4CC(C3)C2)C4)C(=O)c5ccccc15)c6ccc(CO)cc6 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 A13 mock treatment 479120.0 -4780.0 -0.02 370680.0 -22900.0 -0.11 -0.0929 -0.8436 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 A14 mock treatment 324520.0 -159000.0 -0.8 199880.0 -194000.0 -0.91 -1.207 -0.9977 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 A15 compound treatment 438290.0 -45600.0 -0.23 471900.0 78400.0 0.37 0.0996 0.2298 3186552 PK04_095013 OCc1ccc(cc1)[C@@H]2N(Cc3ccccc3C(F)(F)F)C(=O)c4ccccc4[C@]2(Cc5ccccc5I)C(=O)NC6CC6 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 A16 compound treatment 154780.0 -329000.0 -1.64 195460.0 -198000.0 -0.93 -1.8211 -0.9638 3187439 PK04_095014 COCCCNC(=O)[C@]1(C)[C@@H](N(Cc2ccccc2)C(=O)c3ccccc31)c4ccc(CO)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 A17 compound treatment 564700.0 80800.0 0.4 341360.0 -52200.0 -0.25 0.1118 0.2368 3187073 PK04_095015 OCc1ccc(cc1)[C@H]2[C@H](C(=O)NC3CC3)c4ccccc4C(=O)N2Cc5cc(cc(c5)C(F)(F)F)C(F)(F)F 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 A18 compound treatment 469230.0 -14700.0 -0.07 238620.0 -155000.0 -0.73 -0.567 -0.7743 3187272 PK04_095016 COCCCNC(=O)[C@H]1[C@@H](N(C2CCCCC2)C(=O)c3ccccc13)c4ccc(CO)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 A19 compound treatment 336170.0 -148000.0 -0.74 188720.0 -205000.0 -0.96 -1.2029 -0.9913 3187508 PK04_095017 CC(C)N1[C@H](c2ccc(CO)cc2)[C@](CC1=O)(C(=O)NC3CC3)c4ccc(cc4)[N+](=O)[O-] 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 A20 compound treatment 214320.0 -270000.0 -1.35 189440.0 -204000.0 -0.96 -1.6309 -0.9863 3186432 PK04_095018 OCc1ccc2[C@H]3N(C4CCCCC4)C(=O)C[C@@]3(C(=O)N(Cc5ccccc5)c2c1)c6ccc(cc6)[N+](=O)[O-] 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 A21 compound treatment 342090.0 -142000.0 -0.71 289300.0 -104000.0 -0.49 -0.8475 -0.9839 3068646 PK04_095019 COc1ccc(CCNC(=O)[C@]2(C)[C@@H](N(Cc3cc(cc(c3)C(F)(F)F)C(F)(F)F)C(=O)c4ccccc42)c5ccc(CO)cc5)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 A22 compound treatment 430680.0 -53200.0 -0.27 319920.0 -73600.0 -0.35 -0.4328 -0.9915 3068651 PK04_095020 C[C@]1([C@@H](N(Cc2ccccc2)C(=O)c3ccccc31)c4ccc(CO)cc4)C(=O)NC5CC5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 A23 compound treatment 516480.0 32600.0 0.16 364760.0 -28800.0 -0.14 0.0194 0.0915 3187585 PK04_095021 OCc1ccc(cc1)[C@@H]2N(C3CCCCC3)C(=O)c4ccccc4[C@]2(Cc5ccccc5I)C(=O)O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 A24 compound treatment 493280.0 9380.0 0.05 458100.0 64600.0 0.3 0.2479 0.8066 3187430 PK04_095022 C[C@]1([C@@H](N(Cc2cc(cc(c2)C(F)(F)F)C(F)(F)F)C(=O)c3ccccc31)c4ccc(CO)cc4)C(=O)NCc5ccccc5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 B01 compound treatment 228180.0 -256000.0 -1.28 242730.0 -151000.0 -0.71 -1.4047 -0.9615 3187519 PK04_095023 OCc1ccc([C@H]2N(C3CCCCC3)C(=O)C[C@@]2(C(=O)O)c4ccc(cc4)[N+](=O)[O-])c(I)c1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 B02 compound treatment 532320.0 48400.0 0.24 537980.0 144000.0 0.68 0.6514 0.9033 3186885 PK04_095024 Cc1ccc(S[C@@]2(CC(=O)N(Cc3ccccc3Cl)[C@@H]2c4ccc(CO)cc4)C(=O)NCCN5CCOCC5)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 B03 compound treatment 495840.0 11900.0 0.06 534470.0 141000.0 0.66 0.5109 0.7676 3187435 PK04_095025 C[C@]1([C@@H](N(Cc2ccccc2)C(=O)c3ccccc31)c4ccc(CO)cc4)C(=O)NCCN5CCOCC5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 B04 compound treatment 231240.0 -253000.0 -1.26 409760.0 16200.0 0.08 -0.8383 -0.6631 3186491 PK04_095026 CC(C)NC(=O)[C@]1(Cc2ccccc2I)[C@@H](N(C3CCCCC3)C(=O)c4ccccc41)c5ccc(CO)cc5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 B05 compound treatment 555840.0 71900.0 0.36 551720.0 158000.0 0.74 0.7802 0.9442 3068539 PK04_095027 OCc1ccc(cc1)[C@H]2[C@H](C(=O)NCC(F)(F)F)c3ccccc3C(=O)N2Cc4cc(F)cc(c4)C(F)(F)F 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 B06 compound treatment 456540.0 -27400.0 -0.14 197920.0 -196000.0 -0.92 -0.7472 -0.8033 3186559 PK04_095028 COc1ccc(CCNC(=O)[C@]2(Cc3ccccc3I)[C@@H](N(Cc4ccccc4)C(=O)c5ccccc52)c6ccc(CO)cc6)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 B07 compound treatment 519590.0 35700.0 0.18 328680.0 -64900.0 -0.31 -0.0897 -0.2538 3068561 PK04_095029 CCCNC(=O)[C@H]1[C@@H](N(CC2(CC3CC4CC(C3)C2)C4)C(=O)c5ccccc15)c6ccc(CO)cc6 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 B08 compound treatment 208740.0 -275000.0 -1.37 204640.0 -189000.0 -0.89 -1.6 -0.9777 3068322 PK04_095030 Cc1ccc(S[C@@]2(CC(=O)N(Cc3ccccc3)[C@@H]2c4ccc(CO)cc4I)C(=O)NCc5ccccc5)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 B09 compound treatment 475520.0 -8380.0 -0.04 496770.0 103000.0 0.49 0.3138 0.6438 3187432 PK04_095031 CN(C)CCCNC(=O)[C@]1(C)[C@@H](N(Cc2cc(cc(c2)C(F)(F)F)C(F)(F)F)C(=O)c3ccccc31)c4ccc(CO)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 B10 compound treatment 233540.0 -250000.0 -1.25 307880.0 -85700.0 -0.4 -1.1691 -0.8899 3068145 PK04_095032 COc1ccccc1CN2[C@@H](c3ccc(CO)cc3)[C@@](Cc4ccccc4I)(C(=O)NCC(F)(F)F)c5ccccc5C2=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 B11 compound treatment 526280.0 42400.0 0.21 337930.0 -55600.0 -0.26 -0.0353 -0.1048 3187265 PK04_095033 CC(C)N1[C@H]([C@H](C(=O)NCCCN(C)C)c2ccccc2C1=O)c3ccc(CO)cc3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 B12 compound treatment 358110.0 -126000.0 -0.63 404340.0 10800.0 0.05 -0.4083 -0.6478 3186629 PK04_095034 OCc1ccc(cc1)[C@@H]2N(Cc3ccccc3Cl)C(=O)c4ccccc4[C@]52Cc6ccccc6N(CCN7CCOCC7)C5=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 B13 mock treatment 560450.0 76500.0 0.38 491520.0 98000.0 0.46 0.5962 0.9957 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 B14 mock treatment 468600.0 -15300.0 -0.08 327330.0 -66200.0 -0.31 -0.2742 -0.8553 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 B15 compound treatment 428500.0 -55400.0 -0.28 298670.0 -94900.0 -0.45 -0.5112 -0.9736 3187269 PK04_095035 COc1ccc(CCNC(=O)[C@H]2[C@@H](N(C3CCCCC3)C(=O)c4ccccc24)c5ccc(CO)cc5)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 B16 compound treatment 451200.0 -32700.0 -0.16 410610.0 17100.0 0.08 -0.0587 -0.3225 3186887 PK04_095036 CC(C)NC(=O)[C@]1(CC(=O)N(Cc2ccccc2Cl)[C@@H]1c3ccc(CO)cc3)Sc4ccc(C)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 B17 compound treatment 526960.0 43100.0 0.22 401120.0 7590.0 0.04 0.1773 0.8133 3068417 PK04_095037 CCCNC(=O)[C@H]1[C@@H](N(Cc2ccccc2)C(=O)c3ccccc13)c4ccc(CO)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 B18 compound treatment 517440.0 33500.0 0.17 347320.0 -46200.0 -0.22 -0.0353 -0.1285 3067610 PK04_095038 OCc1ccc2[C@H]3N(CC4(CC5CC6CC(C5)C4)C6)C(=O)C[C@@]3(C(=O)N(C7CC7)c2c1)c8ccc(cc8)[N+](=O)[O-] 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 B19 compound treatment 353960.0 -130000.0 -0.65 368090.0 -25400.0 -0.12 -0.5435 -0.8236 3068639 PK04_095039 COc1ccc(CCNC(=O)[C@]2(C)[C@@H](N(Cc3cc(F)cc(c3)C(F)(F)F)C(=O)c4ccccc42)c5ccc(CO)cc5)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 B20 compound treatment 468260.0 -15600.0 -0.08 447740.0 54200.0 0.25 0.1251 0.469 3068006 PK04_095040 Cc1ccc(S[C@@]2(CC(=O)N(Cc3ccccc3Cl)[C@@H]2c4ccc(CO)cc4)C(=O)O)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 B21 compound treatment 381010.0 -103000.0 -0.51 416130.0 22600.0 0.11 -0.2882 -0.5492 3068601 PK04_095041 Cc1ccc(nc1)N2[C@@H](c3ccc(CO)cc3)[C@@](C)(C(=O)NCc4ccccc4)c5ccccc5C2=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 B22 compound treatment 506420.0 22500.0 0.11 216250.0 -177000.0 -0.83 -0.5101 -0.6062 3068203 PK04_095042 COc1ccc(CCN2C(=O)[C@]3(Cc4ccccc24)[C@@H](N(Cc5ccccc5Cl)C(=O)c6ccccc63)c7ccc(CO)cc7)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 B23 compound treatment 469120.0 -14800.0 -0.07 482570.0 89000.0 0.42 0.2439 0.5736 3187355 PK04_095043 Cc1ccc(nc1)N2[C@@H](c3ccc(CO)cc3)[C@@](C)(C(=O)NCC(F)(F)F)c4ccccc4C2=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 B24 compound treatment 457800.0 -26100.0 -0.13 405050.0 11500.0 0.05 -0.0539 -0.3816 3068156 PK04_095044 CC(C)CN1C(=O)[C@]2(Cc3ccccc13)[C@@H](N(C4CCCCC4)C(=O)c5ccccc52)c6ccc(CO)cc6 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 C01 compound treatment 381540.0 -102000.0 -0.51 423610.0 30100.0 0.14 -0.2615 -0.4929 3187590 PK04_095045 C[C@]1([C@@H](N(Cc2cc(F)cc(c2)C(F)(F)F)C(=O)c3ccccc31)c4ccc(CO)cc4)C(=O)O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 C02 compound treatment 456870.0 -27000.0 -0.14 266720.0 -127000.0 -0.6 -0.5172 -0.8458 3187180 PK04_095046 CC(C)NC(=O)[C@H]1[C@@H](N(C(=O)c2ccccc12)c3ccc(C)cn3)c4ccc(CO)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 C03 compound treatment 198110.0 -286000.0 -1.43 192900.0 -201000.0 -0.94 -1.6766 -0.9798 3186493 PK04_095047 COCCCNC(=O)[C@]1(Cc2ccccc2I)[C@@H](N(C3CCCCC3)C(=O)c4ccccc41)c5ccc(CO)cc5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 C04 compound treatment 13920.0 -470000.0 -2.35 25440.0 -368000.0 -1.73 -2.8841 -0.9888 3186427 PK04_095048 CN(C)CCCNC(=O)[C@]1(CC(=O)N(CC2(CC3CC4CC(C3)C2)C4)[C@@H]1c5ccc(CO)cc5I)c6ccc(cc6)[N+](=O)[O-] 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 C05 compound treatment 389390.0 -94500.0 -0.47 237490.0 -156000.0 -0.73 -0.8528 -0.9772 3187172 PK04_095049 COc1ccccc1CN2[C@H]([C@H](C(=O)NCCN3CCOCC3)c4ccccc4C2=O)c5ccc(CO)cc5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 C06 compound treatment 249310.0 -235000.0 -1.17 368420.0 -25100.0 -0.12 -0.912 -0.7745 3187080 PK04_095050 CC(C)NC(=O)[C@H]1[C@@H](N(Cc2ccccc2C(F)(F)F)C(=O)c3ccccc13)c4ccc(CO)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 C07 compound treatment 433010.0 -50900.0 -0.25 261760.0 -132000.0 -0.62 -0.618 -0.9225 3186988 PK04_095051 CC(C)CNC(=O)[C@H]1[C@@H](N(Cc2ccccc2)C(=O)c3ccccc13)c4ccc(CO)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 C08 compound treatment 194250.0 -290000.0 -1.45 191250.0 -202000.0 -0.95 -1.6957 -0.9793 3068011 PK04_095052 Cc1ccc(S[C@@]2(CC(=O)N(Cc3ccccc3Cl)[C@@H]2c4ccc(CO)cc4I)C(=O)O)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 C09 compound treatment 346690.0 -137000.0 -0.69 246480.0 -147000.0 -0.69 -0.9737 -1.0 3068498 PK04_095053 CN(C)CCCNC(=O)[C@H]1[C@@H](N(Cc2cc(F)cc(c2)C(F)(F)F)C(=O)c3ccccc13)c4ccc(CO)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 C10 compound treatment 17710.0 -466000.0 -2.33 29570.0 -364000.0 -1.71 -2.857 -0.9886 3186550 PK04_095054 CN(C)CCCNC(=O)[C@]1(Cc2ccccc2I)[C@@H](N(Cc3ccccc3Cl)C(=O)c4ccccc41)c5ccc(CO)cc5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 C11 mock treatment 495360.0 11500.0 0.06 428580.0 35000.0 0.16 0.157 0.8999 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 C12 mock treatment 508770.0 24900.0 0.12 215210.0 -178000.0 -0.84 -0.5053 -0.5959 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 C13 compound treatment 206210.0 -278000.0 -1.39 398520.0 4990.0 0.02 -0.9641 -0.695 3187361 PK04_095055 C[C@]1([C@@H](N(Cc2ccc(OC(F)(F)F)cc2)C(=O)c3ccccc31)c4ccc(CO)cc4)C(=O)NCC(F)(F)F 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 C14 compound treatment 388480.0 -95400.0 -0.48 269940.0 -124000.0 -0.58 -0.7481 -0.9951 3068504 PK04_095056 COc1ccc(CCNC(=O)[C@H]2[C@@H](N(Cc3ccc(OC(F)(F)F)cc3)C(=O)c4ccccc24)c5ccc(CO)cc5)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 C15 mock treatment 474780.0 -9120.0 -0.05 225610.0 -168000.0 -0.79 -0.5907 -0.7466 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 C16 mock treatment 440240.0 -43700.0 -0.22 227330.0 -166000.0 -0.78 -0.707 -0.8711 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 C17 compound treatment 442920.0 -41000.0 -0.2 311680.0 -81900.0 -0.39 -0.417 -0.9563 3067969 PK04_095057 CC(C)N1[C@H](c2ccc(CO)cc2)[C@](CC1=O)(C(=O)NCCCN(C)C)c3ccc(cc3)[N+](=O)[O-] 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 C18 compound treatment 180350.0 -304000.0 -1.52 205040.0 -188000.0 -0.89 -1.699 -0.9674 3187359 PK04_095058 COc1ccc(CCNC(=O)[C@]2(C)[C@@H](N(Cc3ccc(OC(F)(F)F)cc3)C(=O)c4ccccc42)c5ccc(CO)cc5)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 C19 compound treatment 336100.0 -148000.0 -0.74 238640.0 -155000.0 -0.73 -1.0372 -1.0 3187087 PK04_095059 CN(C)CCCNC(=O)[C@H]1[C@@H](N(Cc2ccccc2Cl)C(=O)c3ccccc13)c4ccc(CO)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 C20 compound treatment 286340.0 -198000.0 -0.99 296670.0 -96900.0 -0.46 -1.0199 -0.9384 3187443 PK04_095060 COCCCNC(=O)[C@]1(CC(=O)N([C@@H]1c2ccc(CO)cc2)C3CCCCC3)c4ccc(cc4)[N+](=O)[O-] 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 C21 compound treatment 228810.0 -255000.0 -1.27 296480.0 -97100.0 -0.46 -1.2237 -0.9042 3067571 PK04_095061 COCCCNC(=O)[C@]1(CC(=O)N([C@@H]1c2ccc(CO)cc2I)C3CCCCC3)c4ccc(cc4)[N+](=O)[O-] 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 C22 compound treatment 392930.0 -91000.0 -0.45 336540.0 -57000.0 -0.27 -0.5108 -0.9683 3187181 PK04_095062 Cc1ccc(nc1)N2[C@H]([C@H](C(=O)NCC(F)(F)F)c3ccccc3C2=O)c4ccc(CO)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 C23 compound treatment 321890.0 -162000.0 -0.81 362450.0 -31100.0 -0.15 -0.6755 -0.8216 3187509 PK04_095063 COc1ccc(CCNC(=O)[C@]2(CC(=O)N(C(C)C)[C@@H]2c3ccc(CO)cc3)c4ccc(cc4)[N+](=O)[O-])cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 C24 compound treatment 451720.0 -32200.0 -0.16 331330.0 -62200.0 -0.29 -0.3205 -0.9602 3068474 PK04_095064 CCCNC(=O)[C@H]1[C@@H](N(Cc2cc(F)cc(c2)C(F)(F)F)C(=O)c3ccccc13)c4ccc(CO)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 D01 compound treatment 172710.0 -311000.0 -1.55 436720.0 43200.0 0.2 -0.9554 -0.6095 3068587 PK04_095065 COc1ccc(CCNC(=O)[C@H]2[C@@H](N(CC3(CC4CC5CC(C4)C3)C5)C(=O)c6ccccc26)c7ccc(CO)cc7)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 D02 compound treatment 219250.0 -265000.0 -1.32 219520.0 -174000.0 -0.82 -1.5134 -0.9734 3068318 PK04_095066 Cc1ccc(S[C@@]2(CC(=O)N(Cc3cc(cc(c3)C(F)(F)F)C(F)(F)F)[C@@H]2c4ccc(CO)cc4I)C(=O)NCC(F)(F)F)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 D03 compound treatment 471860.0 -12000.0 -0.06 516120.0 123000.0 0.58 0.3652 0.6299 3187363 PK04_095067 CCCNC(=O)[C@]1(C)[C@@H](N(Cc2cc(F)cc(c2)C(F)(F)F)C(=O)c3ccccc31)c4ccc(CO)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 D04 compound treatment 537650.0 53700.0 0.27 494970.0 101000.0 0.48 0.5272 0.963 3186486 PK04_095068 OCc1ccc2[C@H]3N(CC4(CC5CC6CC(C5)C4)C6)C(=O)C[C@@]3(C(=O)N(CCN7CCOCC7)c2c1)c8ccc(cc8)[N+](=O)[O-] 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 D05 compound treatment 550690.0 66800.0 0.33 576960.0 183000.0 0.86 0.846 0.9145 3187179 PK04_095069 COc1ccc(CCNC(=O)[C@H]2[C@@H](N(C(=O)c3ccccc23)c4ccc(C)cn4)c5ccc(CO)cc5)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 D06 compound treatment 265630.0 -218000.0 -1.09 250040.0 -143000.0 -0.67 -1.2481 -0.9734 3187522 PK04_095070 Cc1ccc(S[C@@]2(CC(=O)N([C@@H]2c3ccc(CO)cc3I)C4CCCCC4)C(=O)O)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 D07 compound treatment 471380.0 -12500.0 -0.06 473240.0 79700.0 0.37 0.2209 0.5811 3068515 PK04_095071 Cc1ccc(nc1)N2[C@H]([C@H](C(=O)NC3CC3)c4ccccc4C2=O)c5ccc(CO)cc5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 D08 compound treatment 492800.0 8900.0 0.04 437920.0 44400.0 0.21 0.1791 0.8389 3186872 PK04_095072 COCCCNC(=O)[C@]1(CC(=O)N([C@@H]1c2ccc(CO)cc2)C3CCCCC3)Sc4ccc(C)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 D09 compound treatment 493150.0 9250.0 0.05 414400.0 20900.0 0.1 0.1021 0.9409 3068609 PK04_095073 CN(C)CCCNC(=O)[C@]1(C)[C@@H](N(Cc2ccc(OC(F)(F)F)cc2)C(=O)c3ccccc31)c4ccc(CO)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 D10 compound treatment 235740.0 -248000.0 -1.24 235390.0 -158000.0 -0.74 -1.4024 -0.9702 3186795 PK04_095074 CC(C)CNC(=O)[C@]1(CC(=O)N(Cc2cc(cc(c2)C(F)(F)F)C(F)(F)F)[C@@H]1c3ccc(CO)cc3I)Sc4ccc(C)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 D11 mock treatment 488240.0 4340.0 0.02 300320.0 -93200.0 -0.44 -0.2947 -0.6713 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 D12 mock treatment 527150.0 43200.0 0.22 271860.0 -122000.0 -0.57 -0.2519 -0.4119 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 D13 compound treatment 469840.0 -14100.0 -0.07 404720.0 11200.0 0.05 -0.0124 -0.1419 3067964 PK04_095075 CCCNC(=O)[C@]1(CC(=O)N(C(C)C)[C@@H]1c2ccc(CO)cc2)c3ccc(cc3)[N+](=O)[O-] 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 D14 compound treatment 561450.0 77500.0 0.39 439680.0 46100.0 0.22 0.4274 0.9625 3068230 PK04_095076 CC(C)CN1C(=O)[C@]2(Cc3ccccc13)[C@@H](N(Cc4ccccc4)C(=O)c5ccccc52)c6ccc(CO)cc6 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 D15 mock treatment 238720.0 -245000.0 -1.22 507200.0 114000.0 0.53 -0.4878 -0.3651 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 D16 mock treatment 476810.0 -7090.0 -0.04 494320.0 101000.0 0.47 0.3102 0.6525 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 D17 compound treatment 489550.0 5650.0 0.03 379270.0 -14300.0 -0.07 -0.0275 -0.3777 3068595 PK04_095077 CC(C)N1[C@@H](c2ccc(CO)cc2)[C@@](C)(C(=O)NCc3ccccc3)c4ccccc4C1=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 D18 compound treatment 383730.0 -100000.0 -0.5 229220.0 -164000.0 -0.77 -0.9003 -0.9778 3186982 PK04_095078 CC(C)CNC(=O)[C@]1(CC(=O)N(Cc2ccccc2)[C@@H]1c3ccc(CO)cc3)Sc4ccc(C)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 D19 compound treatment 360220.0 -124000.0 -0.62 205400.0 -188000.0 -0.88 -1.0625 -0.9846 3187440 PK04_095079 CC(C)CNC(=O)[C@]1(CC(=O)N([C@@H]1c2ccc(CO)cc2)C3CCCCC3)c4ccc(cc4)[N+](=O)[O-] 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 D20 compound treatment 486510.0 2610.0 0.01 281320.0 -112000.0 -0.53 -0.364 -0.6894 3068415 PK04_095080 CN(C)CCCNC(=O)[C@]1(CC(=O)N(Cc2ccccc2)[C@@H]1c3ccc(CO)cc3)Sc4ccc(C)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 D21 compound treatment 469340.0 -14600.0 -0.07 436930.0 43400.0 0.2 0.0929 0.4288 3068596 PK04_095081 CC(C)N1[C@@H](c2ccc(CO)cc2)[C@@](C)(C(=O)NCC(F)(F)F)c3ccccc3C1=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 D22 compound treatment 204910.0 -279000.0 -1.39 197490.0 -196000.0 -0.92 -1.6373 -0.9799 3186713 PK04_095082 CC(C)CNC(=O)[C@]1(CC(=O)N(C(C)C)[C@@H]1c2ccc(CO)cc2I)Sc3ccc(C)cc3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 D23 compound treatment 461800.0 -22100.0 -0.11 460830.0 67300.0 0.32 0.1458 0.4349 3187357 PK04_095083 CC(C)CNC(=O)[C@]1(C)[C@@H](N(Cc2ccc(OC(F)(F)F)cc2)C(=O)c3ccccc31)c4ccc(CO)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 D24 compound treatment 197780.0 -286000.0 -1.43 232130.0 -161000.0 -0.76 -1.5473 -0.9562 3068270 PK04_095084 Cc1ccc(S[C@@]2(CC(=O)N(C3Cc4ccccc4C3)[C@@H]2c5ccc(CO)cc5I)C(=O)NCCN6CCOCC6)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 E01 mock treatment 504030.0 20100.0 0.1 290600.0 -103000.0 -0.48 -0.2713 -0.5486 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 E02 mock treatment 545400.0 61500.0 0.31 540130.0 147000.0 0.69 0.7048 0.9336 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 E03 compound treatment 367200.0 -117000.0 -0.58 377760.0 -15800.0 -0.07 -0.4646 -0.7907 3068636 PK04_095085 C[C@]1([C@@H](N(Cc2cc(F)cc(c2)C(F)(F)F)C(=O)c3ccccc31)c4ccc(CO)cc4)C(=O)NC5CC5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 E04 compound treatment 579310.0 95400.0 0.48 519770.0 126000.0 0.59 0.7568 0.9941 3186556 PK04_095086 COCCCNC(=O)[C@]1(Cc2ccccc2I)[C@@H](N(Cc3ccccc3C(F)(F)F)C(=O)c4ccccc41)c5ccc(CO)cc5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 E05 compound treatment 572580.0 88700.0 0.44 212450.0 -181000.0 -0.85 -0.2891 -0.3011 3187587 PK04_095087 OCc1ccc(cc1)[C@@H]2N(Cc3ccccc3C(F)(F)F)C(=O)c4ccccc4[C@]2(Cc5ccccc5I)C(=O)O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 E06 compound treatment 202350.0 -282000.0 -1.41 164100.0 -229000.0 -1.08 -1.7574 -0.9915 3186428 PK04_095088 COCCCNC(=O)[C@]1(CC(=O)N(CC2(CC3CC4CC(C3)C2)C4)[C@@H]1c5ccc(CO)cc5I)c6ccc(cc6)[N+](=O)[O-] 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 E07 compound treatment 575840.0 91900.0 0.46 506720.0 113000.0 0.53 0.7012 0.9973 3187266 PK04_095089 CCCNC(=O)[C@H]1[C@@H](N(C2CCCCC2)C(=O)c3ccccc13)c4ccc(CO)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 E08 compound treatment 550560.0 66700.0 0.33 524330.0 131000.0 0.62 0.6704 0.9584 3187351 PK04_095090 CC(C)CNC(=O)[C@]1(C)[C@@H](N(C(=O)c2ccccc21)c3ccc(C)cn3)c4ccc(CO)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 E09 mock treatment 460770.0 -23100.0 -0.12 506000.0 112000.0 0.53 0.2924 0.54 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 E10 mock treatment 508970.0 25100.0 0.13 536750.0 143000.0 0.67 0.5649 0.8244 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 E11 compound treatment 509800.0 25900.0 0.13 306780.0 -86800.0 -0.41 -0.1971 -0.4604 3068004 PK04_095091 Cc1ccc(S[C@@]2(CC(=O)N(Cc3cc(cc(c3)C(F)(F)F)C(F)(F)F)[C@@H]2c4ccc(CO)cc4)C(=O)O)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 E12 compound treatment 408920.0 -75000.0 -0.37 254480.0 -139000.0 -0.65 -0.7273 -0.965 3186500 PK04_095092 OCc1ccc(cc1)[C@@H]2N(Cc3ccccc3Cl)C(=O)c4ccccc4[C@]2(Cc5ccccc5I)C(=O)NC6CC6 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 E13 compound treatment 305280.0 -179000.0 -0.89 288710.0 -105000.0 -0.49 -0.9795 -0.9609 3187346 PK04_095093 CC(C)N1[C@@H](c2ccc(CO)cc2)[C@@](C)(C(=O)NCCN3CCOCC3)c4ccccc4C1=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 E14 compound treatment 423570.0 -60300.0 -0.3 264560.0 -129000.0 -0.61 -0.642 -0.9478 3187262 PK04_095094 CC(C)N1[C@H]([C@H](C(=O)NCCN2CCOCC2)c3ccccc3C1=O)c4ccc(CO)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 E15 compound treatment 163650.0 -320000.0 -1.6 198990.0 -195000.0 -0.92 -1.7781 -0.9649 3067574 PK04_095095 OCc1ccc([C@H]2N(CC3(CC4CC5CC(C4)C3)C5)C(=O)C[C@@]2(C(=O)NC6CC6)c7ccc(cc7)[N+](=O)[O-])c(I)c1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 E16 compound treatment 479840.0 -4060.0 -0.02 493860.0 100000.0 0.47 0.3193 0.6761 3187350 PK04_095096 COCCCNC(=O)[C@]1(C)[C@@H](N(C(C)C)C(=O)c2ccccc21)c3ccc(CO)cc3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 E17 mock treatment 562260.0 78400.0 0.39 394610.0 1080.0 0.01 0.2803 0.7162 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 E18 mock treatment 445240.0 -38700.0 -0.19 393470.0 -63.4 0.0 -0.1367 -0.7082 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 E19 compound treatment 374410.0 -109000.0 -0.55 263040.0 -130000.0 -0.61 -0.8207 -0.9983 3068657 PK04_095097 CCCNC(=O)[C@]1(CC(=O)N([C@@H]1c2ccc(CO)cc2)C3CCCCC3)c4ccc(cc4)[N+](=O)[O-] 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 E20 compound treatment 219680.0 -264000.0 -1.32 233490.0 -160000.0 -0.75 -1.4654 -0.9646 3068140 PK04_095098 OCc1ccc(cc1)[C@@H]2N(C3CCCCC3)C(=O)c4ccccc4[C@]2(Cc5ccccc5I)C(=O)NC6CC6 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 E21 compound treatment 186750.0 -297000.0 -1.48 307160.0 -86400.0 -0.41 -1.3367 -0.8687 3186562 PK04_095099 COCCCNC(=O)[C@]1(Cc2ccccc2I)[C@@H](N(Cc3ccccc3)C(=O)c4ccccc41)c5ccc(CO)cc5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 E22 compound treatment 495730.0 11800.0 0.06 311270.0 -82300.0 -0.39 -0.2318 -0.5923 3187591 PK04_095100 C[C@]1([C@@H](N(Cc2ccccc2)C(=O)c3ccccc31)c4ccc(CO)cc4)C(=O)O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 E23 compound treatment 426990.0 -56900.0 -0.28 422720.0 29200.0 0.14 -0.1039 -0.3292 3187263 PK04_095101 CC(C)N1[C@H]([C@H](C(=O)NCc2ccccc2)c3ccccc3C1=O)c4ccc(CO)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 E24 compound treatment 545440.0 61500.0 0.31 342460.0 -51100.0 -0.24 0.0475 0.1217 3068517 PK04_095102 Cc1ccc(nc1)N2[C@H]([C@H](C(=O)NCc3ccccc3)c4ccccc4C2=O)c5ccc(CO)cc5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 F01 mock treatment 586350.0 102000.0 0.51 210440.0 -183000.0 -0.86 -0.2471 -0.2467 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 F02 mock treatment 569630.0 85700.0 0.43 511420.0 118000.0 0.55 0.6949 0.9918 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 F03 compound treatment 518180.0 34300.0 0.17 495160.0 102000.0 0.48 0.4591 0.9041 3187079 PK04_095103 COc1ccc(CCNC(=O)[C@H]2[C@@H](N(Cc3ccccc3C(F)(F)F)C(=O)c4ccccc24)c5ccc(CO)cc5)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 F04 compound treatment 223230.0 -261000.0 -1.3 180860.0 -213000.0 -1.0 -1.6279 -0.9915 3068331 PK04_095104 CN(C)CCCNC(=O)[C@]1(CC(=O)N([C@@H]1c2ccc(CO)cc2)C3CCCCC3)Sc4ccc(C)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 F05 compound treatment 188070.0 -296000.0 -1.48 170260.0 -223000.0 -1.05 -1.7874 -0.986 3068563 PK04_095105 OCc1ccc(cc1)[C@H]2[C@H](C(=O)NCCN3CCOCC3)c4ccccc4C(=O)N2CC5(CC6CC7CC(C6)C5)C7 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 F06 compound treatment 324960.0 -159000.0 -0.79 296960.0 -96600.0 -0.45 -0.8825 -0.9649 3186879 PK04_095106 Cc1ccc(S[C@@]2(CC(=O)N(C3Cc4ccccc4C3)[C@@H]2c5ccc(CO)cc5)C(=O)NCCN6CCOCC6)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 F07 compound treatment 231040.0 -253000.0 -1.26 233610.0 -160000.0 -0.75 -1.4249 -0.9694 3187523 PK04_095107 Cc1ccc(S[C@@]2(CC(=O)N(C3Cc4ccccc4C3)[C@@H]2c5ccc(CO)cc5I)C(=O)O)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 F08 compound treatment 558400.0 74500.0 0.37 505600.0 112000.0 0.53 0.6358 0.9855 3186563 PK04_095108 OCc1ccc(cc1)[C@@H]2N(C3CCCCC3)C(=O)c4ccccc4[C@]52Cc6ccccc6N(C7CC7)C5=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 F09 mock treatment 548280.0 64400.0 0.32 354400.0 -39100.0 -0.18 0.0972 0.2624 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 F10 mock treatment 414260.0 -69600.0 -0.35 217960.0 -176000.0 -0.83 -0.8299 -0.9261 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 F11 compound treatment 527240.0 43300.0 0.22 395450.0 1920.0 0.01 0.1594 0.7359 3187257 PK04_095109 OCc1ccc(cc1)[C@H]2[C@H](C(=O)NCc3ccccc3)c4ccccc4C(=O)N2C5Cc6ccccc6C5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 F12 compound treatment 218440.0 -265000.0 -1.33 175400.0 -218000.0 -1.03 -1.663 -0.992 3068241 PK04_095110 CCCNC(=O)[C@]1(CC(=O)N(C(C)C)[C@@H]1c2ccc(CO)cc2I)Sc3ccc(C)cc3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 F13 compound treatment 295700.0 -188000.0 -0.94 569720.0 176000.0 0.83 -0.0787 -0.0628 3068554 PK04_095111 COCCCNC(=O)[C@H]1[C@@H](N(C(C)C)C(=O)c2ccccc12)c3ccc(CO)cc3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 F14 compound treatment 266190.0 -218000.0 -1.09 275970.0 -118000.0 -0.55 -1.1599 -0.9508 3068362 PK04_095112 COc1ccc(CCNC(=O)[C@]2(CC(=O)N(C(C)C)[C@@H]2c3ccc(CO)cc3)Sc4ccc(C)cc4)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 F15 compound treatment 268000.0 -216000.0 -1.08 234090.0 -159000.0 -0.75 -1.2928 -0.9843 3186423 PK04_095113 CC(C)CNC(=O)[C@]1(CC(=O)N(CC2(CC3CC4CC(C3)C2)C4)[C@@H]1c5ccc(CO)cc5I)c6ccc(cc6)[N+](=O)[O-] 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 F16 compound treatment 289210.0 -195000.0 -0.97 344170.0 -49400.0 -0.23 -0.8518 -0.852 3068012 PK04_095114 OCc1ccc(cc1)[C@H]2N(C3CCCCC3)C(=O)C[C@@]2(C(=O)O)c4ccc(cc4)[N+](=O)[O-] 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 F17 mock treatment 514360.0 30500.0 0.15 288600.0 -105000.0 -0.49 -0.2414 -0.4675 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 F18 mock treatment 517890.0 34000.0 0.17 491040.0 97500.0 0.46 0.4443 0.9086 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 F19 compound treatment 182050.0 -302000.0 -1.51 231250.0 -162000.0 -0.76 -1.6058 -0.9503 3067568 PK04_095115 COc1ccc(CCNC(=O)[C@]2(CC(=O)N([C@@H]2c3ccc(CO)cc3I)C4CCCCC4)c5ccc(cc5)[N+](=O)[O-])cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 F20 compound treatment 191900.0 -292000.0 -1.46 212230.0 -181000.0 -0.85 -1.6343 -0.9673 3068266 PK04_095116 CC(C)N1[C@H](c2ccc(CO)cc2I)[C@@](CC1=O)(Sc3ccc(C)cc3)C(=O)NCC(F)(F)F 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 F21 compound treatment 155310.0 -329000.0 -1.64 225380.0 -168000.0 -0.79 -1.7197 -0.944 3186419 PK04_095117 OCc1ccc([C@H]2N(C3CCCCC3)C(=O)C[C@@]2(C(=O)NCc4ccccc4)c5ccc(cc5)[N+](=O)[O-])c(I)c1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 F22 compound treatment 207610.0 -276000.0 -1.38 208240.0 -185000.0 -0.87 -1.592 -0.9754 3187524 PK04_095118 Cc1ccc(S[C@@]2(CC(=O)N(Cc3cc(cc(c3)C(F)(F)F)C(F)(F)F)[C@@H]2c4ccc(CO)cc4I)C(=O)O)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 F23 compound treatment 441600.0 -42300.0 -0.21 352660.0 -40900.0 -0.19 -0.2853 -0.9989 3068017 PK04_095119 Cc1ccc(nc1)N2[C@@H](c3ccc(CO)cc3)[C@@](C)(C(=O)O)c4ccccc4C2=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 F24 compound treatment 441850.0 -42100.0 -0.21 460110.0 66600.0 0.31 0.0729 0.1934 3186554 PK04_095120 OCc1ccc(cc1)[C@@H]2N(Cc3ccccc3C(F)(F)F)C(=O)c4ccccc4[C@]2(Cc5ccccc5I)C(=O)NCc6ccccc6 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 G01 compound treatment 158730.0 -325000.0 -1.62 297820.0 -95700.0 -0.45 -1.4667 -0.8703 3186418 PK04_095121 OCc1ccc([C@H]2N(C3CCCCC3)C(=O)C[C@@]2(C(=O)NCCN4CCOCC4)c5ccc(cc5)[N+](=O)[O-])c(I)c1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 G02 compound treatment 498170.0 14300.0 0.07 205220.0 -188000.0 -0.89 -0.5759 -0.6481 3067966 PK04_095122 CC(C)N1[C@H](c2ccc(CO)cc2)[C@](CC1=O)(C(=O)NCCN3CCOCC3)c4ccc(cc4)[N+](=O)[O-] 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 G03 mock treatment 536810.0 52900.0 0.26 544270.0 151000.0 0.71 0.6882 0.9095 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 G04 mock treatment 582940.0 99000.0 0.49 536690.0 143000.0 0.67 0.8259 0.9885 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 G05 compound treatment 163760.0 -320000.0 -1.6 175230.0 -218000.0 -1.03 -1.8567 -0.9771 3068153 PK04_095123 OCc1ccc(cc1)[C@@H]2N(Cc3ccccc3)C(=O)c4ccccc4[C@]2(Cc5ccccc5I)C(=O)NC6CC6 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 G06 compound treatment 578530.0 94600.0 0.47 267130.0 -126000.0 -0.59 -0.0862 -0.1135 3187356 PK04_095124 COCCCNC(=O)[C@]1(C)[C@@H](N(C(=O)c2ccccc21)c3ccc(C)cn3)c4ccc(CO)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 G07 compound treatment 272960.0 -211000.0 -1.05 192930.0 -201000.0 -0.94 -1.4122 -0.9985 3187173 PK04_095125 COc1ccc(CCNC(=O)[C@H]2[C@@H](N(Cc3ccccc3OC)C(=O)c4ccccc24)c5ccc(CO)cc5)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 G08 compound treatment 463840.0 -20100.0 -0.1 295320.0 -98200.0 -0.46 -0.3975 -0.8409 3068514 PK04_095126 CCCNC(=O)[C@H]1[C@@H](N(C(=O)c2ccccc12)c3ccc(C)cn3)c4ccc(CO)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 G09 compound treatment 279040.0 -205000.0 -1.02 474040.0 80500.0 0.38 -0.4557 -0.4177 3187442 PK04_095127 OCc1ccc(cc1)[C@H]2N(C3CCCCC3)C(=O)C[C@@]2(C(=O)NCC(F)(F)F)c4ccc(cc4)[N+](=O)[O-] 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 G10 compound treatment 478080.0 -5820.0 -0.03 524340.0 131000.0 0.62 0.4145 0.6729 3068420 PK04_095128 CC(C)NC(=O)[C@H]1[C@@H](N(Cc2ccccc2)C(=O)c3ccccc13)c4ccc(CO)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 G11 compound treatment 453130.0 -30800.0 -0.15 357630.0 -35900.0 -0.17 -0.2281 -0.9989 3187434 PK04_095129 CC(C)CNC(=O)[C@]1(C)[C@@H](N(Cc2ccccc2)C(=O)c3ccccc31)c4ccc(CO)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 G12 compound treatment 165180.0 -319000.0 -1.59 133620.0 -260000.0 -1.22 -1.9901 -0.9915 3186416 PK04_095130 CCCNC(=O)[C@]1(CC(=O)N([C@@H]1c2ccc(CO)cc2I)C3CCCCC3)c4ccc(cc4)[N+](=O)[O-] 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 G13 compound treatment 379520.0 -104000.0 -0.52 526930.0 133000.0 0.63 0.075 0.092 3068507 PK04_095131 COCCCNC(=O)[C@H]1[C@@H](N(Cc2ccc(OC(F)(F)F)cc2)C(=O)c3ccccc13)c4ccc(CO)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 G14 compound treatment 527160.0 43300.0 0.22 295100.0 -98400.0 -0.46 -0.1746 -0.3417 3187162 PK04_095132 OCc1ccc(cc1)[C@H]2[C@H](C(=O)NC3CC3)c4ccccc4C(=O)N2Cc5cc(F)cc(c5)C(F)(F)F 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 G15 compound treatment 504770.0 20900.0 0.1 572730.0 179000.0 0.84 0.6697 0.7885 3068602 PK04_095133 CN(C)CCCNC(=O)[C@]1(C)[C@@H](N(C(=O)c2ccccc21)c3ccc(C)cn3)c4ccc(CO)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 G16 compound treatment 313720.0 -170000.0 -0.85 311240.0 -82300.0 -0.39 -0.8747 -0.9366 3187426 PK04_095134 CN(C)CCCNC(=O)[C@]1(C)[C@@H](N(Cc2cc(F)cc(c2)C(F)(F)F)C(=O)c3ccccc31)c4ccc(CO)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 G17 compound treatment 174720.0 -309000.0 -1.54 191790.0 -202000.0 -0.95 -1.7629 -0.9727 3067567 PK04_095135 CC(C)CNC(=O)[C@]1(CC(=O)N([C@@H]1c2ccc(CO)cc2I)C3CCCCC3)c4ccc(cc4)[N+](=O)[O-] 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 G18 compound treatment 230040.0 -254000.0 -1.27 208640.0 -185000.0 -0.87 -1.5115 -0.9831 3187525 PK04_095136 Cc1ccc(S[C@@]2(CC(=O)N(Cc3ccccc3C(F)(F)F)[C@@H]2c4ccc(CO)cc4I)C(=O)O)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 G19 mock treatment 310890.0 -173000.0 -0.86 446330.0 52800.0 0.25 -0.4354 -0.4843 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 G20 mock treatment 409060.0 -74800.0 -0.37 446560.0 53000.0 0.25 -0.0879 -0.1957 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 G21 compound treatment 499930.0 16000.0 0.08 282030.0 -112000.0 -0.52 -0.3142 -0.5923 3187167 PK04_095137 OCc1ccc(cc1)[C@H]2[C@H](C(=O)NCc3ccccc3)c4ccccc4C(=O)N2Cc5ccc(OC(F)(F)F)cc5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 G22 compound treatment 455160.0 -28700.0 -0.14 311790.0 -81700.0 -0.38 -0.3734 -0.9098 3187174 PK04_095138 COc1ccccc1CN2[C@H]([C@H](C(=O)NC(C)C)c3ccccc3C2=O)c4ccc(CO)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 G23 compound treatment 444910.0 -39000.0 -0.19 396670.0 3140.0 0.01 -0.1273 -0.6517 3068478 PK04_095139 CC(C)NC(=O)[C@H]1[C@@H](N(Cc2cc(F)cc(c2)C(F)(F)F)C(=O)c3ccccc13)c4ccc(CO)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 G24 compound treatment 502990.0 19100.0 0.1 445800.0 52300.0 0.25 0.2413 0.9149 3068471 PK04_095140 OCc1ccc(cc1)[C@H]2[C@H](C(=O)NCc3ccccc3)c4ccccc4C(=O)N2Cc5ccccc5Cl 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 H01 compound treatment 285940.0 -198000.0 -0.99 238500.0 -155000.0 -0.73 -1.2148 -0.9888 3068149 PK04_095141 COCCCNC(=O)[C@]1(Cc2ccccc2I)[C@@H](N(Cc3ccccc3Cl)C(=O)c4ccccc41)c5ccc(CO)cc5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 H02 compound treatment 189220.0 -295000.0 -1.47 127320.0 -266000.0 -1.25 -1.9261 -0.9968 3068236 PK04_095142 CC(C)CNC(=O)[C@]1(CC(=O)N([C@@H]1c2ccc(CO)cc2I)C3CCCCC3)Sc4ccc(C)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 H03 mock treatment 595050.0 111000.0 0.56 215520.0 -178000.0 -0.84 -0.1995 -0.1986 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 H04 mock treatment 616660.0 133000.0 0.66 509760.0 116000.0 0.55 0.8554 0.9954 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 H05 compound treatment 560040.0 76100.0 0.38 248280.0 -145000.0 -0.68 -0.2142 -0.274 3187083 PK04_095143 CC(C)CNC(=O)[C@H]1[C@@H](N(Cc2ccccc2Cl)C(=O)c3ccccc13)c4ccc(CO)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 H06 compound treatment 174400.0 -310000.0 -1.55 207800.0 -186000.0 -0.87 -1.7108 -0.9635 3068265 PK04_095144 CC(C)N1[C@H](c2ccc(CO)cc2I)[C@@](CC1=O)(Sc3ccc(C)cc3)C(=O)NCc4ccccc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 H07 compound treatment 560920.0 77000.0 0.38 431840.0 38300.0 0.18 0.3994 0.9403 3068458 PK04_095145 CC(C)NC(=O)[C@H]1[C@@H](N(Cc2cc(cc(c2)C(F)(F)F)C(F)(F)F)C(=O)c3ccccc13)c4ccc(CO)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 H08 compound treatment 203040.0 -281000.0 -1.4 162970.0 -231000.0 -1.08 -1.7588 -0.9919 3068401 PK04_095146 Cc1ccc(S[C@@]2(CC(=O)N(Cc3ccccc3C(F)(F)F)[C@@H]2c4ccc(CO)cc4)C(=O)NCC(F)(F)F)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 H09 compound treatment 574110.0 90200.0 0.45 318080.0 -75500.0 -0.35 0.0676 0.1179 3187071 PK04_095147 COCCCNC(=O)[C@H]1[C@@H](N(Cc2ccccc2)C(=O)c3ccccc13)c4ccc(CO)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 H10 compound treatment 265720.0 -218000.0 -1.09 498680.0 105000.0 0.49 -0.4208 -0.3517 3068139 PK04_095148 CC(C)CNC(=O)[C@]1(Cc2ccccc2I)[C@@H](N(C3CCCCC3)C(=O)c4ccccc41)c5ccc(CO)cc5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 H11 compound treatment 493760.0 9860.0 0.05 352440.0 -41100.0 -0.19 -0.1019 -0.5106 3187589 PK04_095149 C[C@]1([C@@H](N(Cc2ccc(OC(F)(F)F)cc2)C(=O)c3ccccc31)c4ccc(CO)cc4)C(=O)O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 H12 compound treatment 518080.0 34200.0 0.17 168160.0 -225000.0 -1.06 -0.6289 -0.5857 3186627 PK04_095150 COCCCN1C(=O)[C@]2(Cc3ccccc13)[C@@H](N(Cc4ccccc4OC)C(=O)c5ccccc52)c6ccc(CO)cc6 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 H13 compound treatment 469720.0 -14200.0 -0.07 482880.0 89300.0 0.42 0.2471 0.5798 3187261 PK04_095151 CC(C)N1[C@H]([C@H](C(=O)NC2CC2)c3ccccc3C1=O)c4ccc(CO)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 H14 compound treatment 300600.0 -183000.0 -0.92 532050.0 139000.0 0.65 -0.1866 -0.1661 3186980 PK04_095152 CN(C)CCCNC(=O)[C@]1(CC(=O)N(Cc2cc(cc(c2)C(F)(F)F)C(F)(F)F)[C@@H]1c3ccc(CO)cc3)Sc4ccc(C)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 H15 compound treatment 214480.0 -269000.0 -1.35 529760.0 136000.0 0.64 -0.4984 -0.3344 3187166 PK04_095153 OCc1ccc(cc1)[C@H]2[C@H](C(=O)NCCN3CCOCC3)c4ccccc4C(=O)N2Cc5ccc(OC(F)(F)F)cc5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 H16 compound treatment 572670.0 88800.0 0.44 329760.0 -63800.0 -0.3 0.1014 0.1894 3186978 PK04_095154 COc1ccc(CCNC(=O)[C@]2(CC(=O)N(Cc3cc(cc(c3)C(F)(F)F)C(F)(F)F)[C@@H]2c4ccc(CO)cc4)Sc5ccc(C)cc5)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 H17 compound treatment 492440.0 8540.0 0.04 512210.0 119000.0 0.56 0.4249 0.7589 3187349 PK04_095155 CC(C)N1[C@@H](c2ccc(CO)cc2)[C@@](C)(C(=O)NCCCN(C)C)c3ccccc3C1=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 H18 compound treatment 376480.0 -107000.0 -0.54 342050.0 -51500.0 -0.24 -0.5506 -0.9354 3068412 PK04_095156 Cc1ccc(S[C@@]2(CC(=O)N(Cc3ccccc3)[C@@H]2c4ccc(CO)cc4)C(=O)NC5CC5)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 H19 mock treatment 424440.0 -59500.0 -0.3 411200.0 17700.0 0.08 -0.1512 -0.4904 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 H20 mock treatment 396680.0 -87200.0 -0.44 453190.0 59700.0 0.28 -0.1096 -0.2115 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 H21 compound treatment 426160.0 -57700.0 -0.29 483070.0 89500.0 0.42 0.0939 0.1839 3187512 PK04_095157 COCCCNC(=O)[C@]1(CC(=O)N(C(C)C)[C@@H]1c2ccc(CO)cc2)c3ccc(cc3)[N+](=O)[O-] 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 H22 compound treatment 210270.0 -274000.0 -1.37 216290.0 -177000.0 -0.83 -1.5559 -0.9719 3186806 PK04_095158 COCCCNC(=O)[C@]1(CC(=O)N(Cc2ccccc2)[C@@H]1c3ccc(CO)cc3I)Sc4ccc(C)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 H23 compound treatment 458570.0 -25300.0 -0.13 374930.0 -18600.0 -0.09 -0.1513 -0.9838 3068599 PK04_095159 Cc1ccc(nc1)N2[C@@H](c3ccc(CO)cc3)[C@@](C)(C(=O)NC4CC4)c5ccccc5C2=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 H24 compound treatment 290590.0 -193000.0 -0.97 494600.0 101000.0 0.48 -0.3466 -0.322 3187586 PK04_095160 OCc1ccc(cc1)[C@@H]2N(Cc3ccccc3Cl)C(=O)c4ccccc4[C@]2(Cc5ccccc5I)C(=O)O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 I01 compound treatment 319250.0 -165000.0 -0.82 205160.0 -188000.0 -0.89 -1.208 -0.9993 3187165 PK04_095161 OCc1ccc(cc1)[C@H]2[C@H](C(=O)NC3CC3)c4ccccc4C(=O)N2Cc5ccc(OC(F)(F)F)cc5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 I02 compound treatment 387280.0 -96600.0 -0.48 422650.0 29100.0 0.14 -0.2444 -0.4872 3068418 PK04_095162 OCc1ccc(cc1)[C@H]2[C@H](C(=O)NCCN3CCOCC3)c4ccccc4C(=O)N2Cc5ccccc5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 I03 compound treatment 498630.0 14700.0 0.07 200920.0 -193000.0 -0.91 -0.5886 -0.6476 3187178 PK04_095163 Cc1ccc(nc1)N2[C@H]([C@H](C(=O)NCCN3CCOCC3)c4ccccc4C2=O)c5ccc(CO)cc5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 I04 compound treatment 338350.0 -146000.0 -0.73 475680.0 82100.0 0.39 -0.2408 -0.2925 3068019 PK04_095164 C[C@]1([C@@H](N(Cc2cc(cc(c2)C(F)(F)F)C(F)(F)F)C(=O)c3ccccc31)c4ccc(CO)cc4)C(=O)O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 I05 mock treatment 518000.0 34100.0 0.17 273480.0 -120000.0 -0.56 -0.2789 -0.4728 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 I06 mock treatment 278150.0 -206000.0 -1.03 305530.0 -88000.0 -0.41 -1.0193 -0.9201 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 I07 compound treatment 511420.0 27500.0 0.14 196330.0 -197000.0 -0.93 -0.5587 -0.5958 3068542 PK04_095165 COc1ccc(CCNC(=O)[C@H]2[C@@H](N(C3Cc4ccccc4C3)C(=O)c5ccccc25)c6ccc(CO)cc6)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 I08 compound treatment 276400.0 -208000.0 -1.04 513410.0 120000.0 0.56 -0.3341 -0.2832 3187345 PK04_095166 CC(C)CNC(=O)[C@]1(C)[C@@H](N(C(C)C)C(=O)c2ccccc21)c3ccc(CO)cc3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 I09 compound treatment 306350.0 -178000.0 -0.89 225970.0 -168000.0 -0.79 -1.1844 -0.9983 3067971 PK04_095167 CCCNC(=O)[C@]1(CC(=O)N(CC2(CC3CC4CC(C3)C2)C4)[C@@H]1c5ccc(CO)cc5)c6ccc(cc6)[N+](=O)[O-] 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 I10 compound treatment 466810.0 -17100.0 -0.09 310500.0 -83000.0 -0.39 -0.3365 -0.8418 3068641 PK04_095168 CC(C)NC(=O)[C@]1(C)[C@@H](N(Cc2cc(F)cc(c2)C(F)(F)F)C(=O)c3ccccc31)c4ccc(CO)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 I11 compound treatment 263910.0 -220000.0 -1.1 248800.0 -145000.0 -0.68 -1.2583 -0.9735 3187358 PK04_095169 C[C@]1([C@@H](N(Cc2ccc(OC(F)(F)F)cc2)C(=O)c3ccccc31)c4ccc(CO)cc4)C(=O)NC5CC5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 I12 compound treatment 531120.0 47200.0 0.24 493630.0 100000.0 0.47 0.4997 0.9489 3068653 PK04_095170 C[C@]1([C@@H](N(Cc2ccccc2)C(=O)c3ccccc31)c4ccc(CO)cc4)C(=O)NCc5ccccc5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 I13 compound treatment 471310.0 -12600.0 -0.06 286500.0 -107000.0 -0.5 -0.4005 -0.7893 3067962 PK04_095171 CN(C)CCCNC(=O)[C@]1(CC(=O)N([C@@H]1c2ccc(CO)cc2)C3CCCCC3)c4ccc(cc4)[N+](=O)[O-] 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 I14 compound treatment 387230.0 -96700.0 -0.48 291680.0 -102000.0 -0.48 -0.6802 -1.0 3068606 PK04_095172 C[C@]1([C@@H](N(Cc2ccc(OC(F)(F)F)cc2)C(=O)c3ccccc31)c4ccc(CO)cc4)C(=O)NCCN5CCOCC5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 I15 compound treatment 533670.0 49800.0 0.25 238820.0 -155000.0 -0.73 -0.3388 -0.4406 3068476 PK04_095173 OCc1ccc(cc1)[C@H]2[C@H](C(=O)NCCN3CCOCC3)c4ccccc4C(=O)N2Cc5cc(F)cc(c5)C(F)(F)F 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 I16 compound treatment 253720.0 -230000.0 -1.15 252030.0 -142000.0 -0.67 -1.2836 -0.9662 3186417 PK04_095174 OCc1ccc([C@H]2N(C3CCCCC3)C(=O)C[C@@]2(C(=O)NC4CC4)c5ccc(cc5)[N+](=O)[O-])c(I)c1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 I17 compound treatment 256030.0 -228000.0 -1.14 409340.0 15800.0 0.07 -0.7522 -0.6595 3187268 PK04_095175 OCc1ccc(cc1)[C@H]2[C@H](C(=O)NCCN3CCOCC3)c4ccccc4C(=O)N2C5CCCCC5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 I18 compound treatment 540430.0 56500.0 0.28 421370.0 27800.0 0.13 0.2922 0.939 3187264 PK04_095176 CC(C)N1[C@H]([C@H](C(=O)NCC(F)(F)F)c2ccccc2C1=O)c3ccc(CO)cc3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 I19 compound treatment 405950.0 -78000.0 -0.39 222030.0 -172000.0 -0.81 -0.8457 -0.9442 3186499 PK04_095177 COCCCNC(=O)[C@]1(Cc2ccccc2I)[C@@H](N(Cc3ccccc3OC)C(=O)c4ccccc41)c5ccc(CO)cc5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 I20 compound treatment 208640.0 -275000.0 -1.37 396480.0 2950.0 0.01 -0.9623 -0.6999 3068422 PK04_095178 CN(C)CCCNC(=O)[C@H]1[C@@H](N(Cc2ccccc2)C(=O)c3ccccc13)c4ccc(CO)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 I21 mock treatment 439200.0 -44700.0 -0.22 453780.0 60200.0 0.28 0.0425 0.1178 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 I22 mock treatment 527130.0 43200.0 0.22 416320.0 22800.0 0.11 0.2285 0.9478 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 I23 compound treatment 374680.0 -109000.0 -0.55 445800.0 52300.0 0.25 -0.2119 -0.3541 3068550 PK04_095179 COc1ccc(CCNC(=O)[C@H]2[C@@H](N(C(C)C)C(=O)c3ccccc23)c4ccc(CO)cc4)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 I24 compound treatment 471890.0 -12000.0 -0.06 388930.0 -4600.0 -0.02 -0.0577 -0.9052 3187258 PK04_095180 OCc1ccc(cc1)[C@H]2[C@H](C(=O)NCC(F)(F)F)c3ccccc3C(=O)N2C4Cc5ccccc5C4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 J01 compound treatment 407930.0 -76000.0 -0.38 487410.0 93900.0 0.44 0.0439 0.0755 3187273 PK04_095181 CC(C)CNC(=O)[C@H]1[C@@H](N(CC2(CC3CC4CC(C3)C2)C4)C(=O)c5ccccc15)c6ccc(CO)cc6 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 J02 compound treatment 467060.0 -16800.0 -0.08 469440.0 75900.0 0.36 0.193 0.5261 3186630 PK04_095182 OCc1ccc(cc1)[C@@H]2N(Cc3ccccc3Cl)C(=O)c4ccccc4[C@]52Cc6ccccc6N(Cc7ccccc7)C5=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 J03 compound treatment 260760.0 -223000.0 -1.11 204760.0 -189000.0 -0.89 -1.4159 -0.9937 3187353 PK04_095183 COc1ccc(CCNC(=O)[C@]2(C)[C@@H](N(C(=O)c3ccccc32)c4ccc(C)cn4)c5ccc(CO)cc5)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 J04 compound treatment 341460.0 -142000.0 -0.71 534960.0 141000.0 0.67 -0.0327 -0.0335 3187588 PK04_095184 CC(C)N1[C@@H](c2ccc(CO)cc2)[C@@](C)(C(=O)O)c3ccccc3C1=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 J05 mock treatment 564350.0 80400.0 0.4 416580.0 23000.0 0.11 0.3608 0.8669 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 J06 mock treatment 123440.0 -360000.0 -1.8 214620.0 -179000.0 -0.84 -1.8681 -0.94 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 J07 compound treatment 146780.0 -337000.0 -1.68 141450.0 -252000.0 -1.19 -2.029 -0.9853 3186420 PK04_095185 OCc1ccc([C@H]2N(C3CCCCC3)C(=O)C[C@@]2(C(=O)NCC(F)(F)F)c4ccc(cc4)[N+](=O)[O-])c(I)c1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 J08 compound treatment 170880.0 -313000.0 -1.56 231850.0 -162000.0 -0.76 -1.6432 -0.9452 3186722 PK04_095186 COCCCNC(=O)[C@]1(CC(=O)N(C2Cc3ccccc3C2)[C@@H]1c4ccc(CO)cc4I)Sc5ccc(C)cc5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 J09 compound treatment 435580.0 -48300.0 -0.24 107200.0 -286000.0 -1.35 -1.123 -0.8207 3186426 PK04_095187 CC(C)NC(=O)[C@]1(CC(=O)N(CC2(CC3CC4CC(C3)C2)C4)[C@@H]1c5ccc(CO)cc5I)c6ccc(cc6)[N+](=O)[O-] 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 J10 compound treatment 325920.0 -158000.0 -0.79 227480.0 -166000.0 -0.78 -1.1102 -1.0 3186639 PK04_095188 OCc1ccc(cc1)[C@@H]2N(Cc3ccccc3)C(=O)c4ccccc4[C@]52Cc6ccccc6N(Cc7ccccc7)C5=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 J11 compound treatment 226010.0 -258000.0 -1.29 198800.0 -195000.0 -0.92 -1.5585 -0.986 3187270 PK04_095189 CC(C)NC(=O)[C@H]1[C@@H](N(C2CCCCC2)C(=O)c3ccccc13)c4ccc(CO)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 J12 compound treatment 467360.0 -16500.0 -0.08 163850.0 -230000.0 -1.08 -0.8223 -0.759 3067980 PK04_095190 Cc1ccc(S[C@@]2(CC(=O)N(C3Cc4ccccc4C3)[C@@H]2c5ccc(CO)cc5)C(=O)O)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 J13 compound treatment 112080.0 -372000.0 -1.86 48560.0 -345000.0 -1.62 -2.4605 -0.9977 3186421 PK04_095191 CN(C)CCCNC(=O)[C@]1(CC(=O)N([C@@H]1c2ccc(CO)cc2I)C3CCCCC3)c4ccc(cc4)[N+](=O)[O-] 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 J14 compound treatment 234880.0 -249000.0 -1.24 232710.0 -161000.0 -0.76 -1.4143 -0.9716 3068150 PK04_095192 OCc1ccc(cc1)[C@@H]2N(Cc3ccccc3C(F)(F)F)C(=O)c4ccccc4[C@]2(Cc5ccccc5I)C(=O)NCCN6CCOCC6 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 J15 compound treatment 536670.0 52800.0 0.26 269210.0 -124000.0 -0.58 -0.2271 -0.3541 3068598 PK04_095193 CCCNC(=O)[C@]1(C)[C@@H](N(C(=O)c2ccccc21)c3ccc(C)cn3)c4ccc(CO)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 J16 compound treatment 182020.0 -302000.0 -1.51 164510.0 -229000.0 -1.08 -1.8279 -0.9864 3068324 PK04_095194 CN(C)CCCNC(=O)[C@]1(CC(=O)N(Cc2ccccc2)[C@@H]1c3ccc(CO)cc3I)Sc4ccc(C)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 J17 compound treatment 120510.0 -363000.0 -1.81 121340.0 -272000.0 -1.28 -2.1887 -0.9854 3067973 PK04_095195 OCc1ccc(cc1)[C@H]2N(CC3(CC4CC5CC(C4)C3)C5)C(=O)C[C@@]2(C(=O)NCCN6CCOCC6)c7ccc(cc7)[N+](=O)[O-] 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 J18 compound treatment 507840.0 23900.0 0.12 226910.0 -167000.0 -0.78 -0.4696 -0.5924 3068414 PK04_095196 Cc1ccc(S[C@@]2(CC(=O)N(Cc3ccccc3)[C@@H]2c4ccc(CO)cc4)C(=O)NCc5ccccc5)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 J19 compound treatment 375590.0 -108000.0 -0.54 401800.0 8270.0 0.04 -0.355 -0.6546 3187085 PK04_095197 COc1ccc(CCNC(=O)[C@H]2[C@@H](N(Cc3ccccc3Cl)C(=O)c4ccccc24)c5ccc(CO)cc5)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 J20 compound treatment 489200.0 5300.0 0.03 481320.0 87800.0 0.41 0.3107 0.7509 3186884 PK04_095198 CC(C)CNC(=O)[C@]1(CC(=O)N(Cc2ccccc2Cl)[C@@H]1c3ccc(CO)cc3)Sc4ccc(C)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 J21 mock treatment 511690.0 27800.0 0.14 536640.0 143000.0 0.67 0.5741 0.8353 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 J22 mock treatment 466080.0 -17800.0 -0.09 529520.0 136000.0 0.64 0.3894 0.6029 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 J23 compound treatment 456740.0 -27200.0 -0.14 304960.0 -88600.0 -0.42 -0.3905 -0.8913 3187082 PK04_095199 COCCCNC(=O)[C@H]1[C@@H](N(Cc2ccccc2C(F)(F)F)C(=O)c3ccccc13)c4ccc(CO)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 J24 compound treatment 566010.0 82100.0 0.41 401510.0 7980.0 0.04 0.3165 0.7686 3068227 PK04_095200 OCc1ccc(cc1)[C@@H]2N(Cc3ccccc3C(F)(F)F)C(=O)c4ccccc4[C@]52Cc6ccccc6N(CC(F)(F)F)C5=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 K01 compound treatment 179890.0 -304000.0 -1.52 131400.0 -262000.0 -1.23 -1.9455 -0.9947 3187514 PK04_095201 OCc1ccc(cc1)[C@H]2N(CC3(CC4CC5CC(C4)C3)C5)C(=O)C[C@@]2(C(=O)NC6CC6)c7ccc(cc7)[N+](=O)[O-] 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 K02 compound treatment 572480.0 88600.0 0.44 454360.0 60800.0 0.29 0.5151 0.9777 3187168 PK04_095202 OCc1ccc(cc1)[C@H]2[C@H](C(=O)NCC(F)(F)F)c3ccccc3C(=O)N2Cc4ccc(OC(F)(F)F)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 K03 compound treatment 475760.0 -8140.0 -0.04 127930.0 -266000.0 -1.25 -0.9121 -0.7297 3068143 PK04_095203 COc1ccccc1CN2[C@@H](c3ccc(CO)cc3)[C@@](Cc4ccccc4I)(C(=O)NC5CC5)c6ccccc6C2=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 K04 compound treatment 123890.0 -360000.0 -1.8 474310.0 80800.0 0.38 -1.0028 -0.5456 3187275 PK04_095204 CN(C)CCCNC(=O)[C@H]1[C@@H](N(CC2(CC3CC4CC(C3)C2)C4)C(=O)c5ccccc15)c6ccc(CO)cc6 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 K05 compound treatment 603680.0 120000.0 0.6 538720.0 145000.0 0.68 0.9059 0.9978 3187271 PK04_095205 CN(C)CCCNC(=O)[C@H]1[C@@H](N(C2CCCCC2)C(=O)c3ccccc13)c4ccc(CO)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 K06 compound treatment 133200.0 -351000.0 -1.75 100670.0 -293000.0 -1.38 -2.2126 -0.9929 3186561 PK04_095206 CN(C)CCCNC(=O)[C@]1(Cc2ccccc2I)[C@@H](N(Cc3ccccc3)C(=O)c4ccccc41)c5ccc(CO)cc5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 K07 mock treatment 299680.0 -184000.0 -0.92 543590.0 150000.0 0.71 -0.1515 -0.1307 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 K08 mock treatment 632800.0 149000.0 0.74 447950.0 54400.0 0.26 0.7069 0.8987 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 K09 compound treatment 317070.0 -167000.0 -0.83 458610.0 65100.0 0.31 -0.3727 -0.4199 3068519 PK04_095207 CN(C)CCCNC(=O)[C@H]1[C@@H](N(C(=O)c2ccccc12)c3ccc(C)cn3)c4ccc(CO)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 K10 compound treatment 566440.0 82500.0 0.41 249160.0 -144000.0 -0.68 -0.1887 -0.2375 3068466 PK04_095208 OCc1ccc(cc1)[C@H]2[C@H](C(=O)NCC(F)(F)F)c3ccccc3C(=O)N2Cc4ccccc4C(F)(F)F 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 K11 compound treatment 521610.0 37700.0 0.19 491930.0 98400.0 0.46 0.4604 0.9215 3068556 PK04_095209 OCc1ccc(cc1)[C@H]2[C@H](C(=O)NC3CC3)c4ccccc4C(=O)N2C5CCCCC5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 K12 compound treatment 234560.0 -249000.0 -1.25 221030.0 -173000.0 -0.81 -1.4543 -0.9785 3067978 PK04_095210 OCc1ccc([C@H]2N(CC3(CC4CC5CC(C4)C3)C5)C(=O)C[C@@]2(C(=O)O)c6ccc(cc6)[N+](=O)[O-])c(I)c1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 K13 compound treatment 215040.0 -269000.0 -1.34 557410.0 164000.0 0.77 -0.4045 -0.2612 3068499 PK04_095211 COCCCNC(=O)[C@H]1[C@@H](N(Cc2cc(F)cc(c2)C(F)(F)F)C(=O)c3ccccc13)c4ccc(CO)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 K14 compound treatment 273280.0 -211000.0 -1.05 199690.0 -194000.0 -0.91 -1.3886 -0.9975 3068588 PK04_095212 OCc1ccc(cc1)[C@H]2[C@H](C(=O)NCc3ccccc3)c4ccccc4C(=O)N2CC5(CC6CC7CC(C6)C5)C7 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 K15 mock treatment 633730.0 150000.0 0.75 322970.0 -70600.0 -0.33 0.2945 0.3597 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 K16 mock treatment 627560.0 144000.0 0.72 219410.0 -174000.0 -0.82 -0.0718 -0.0659 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 K17 compound treatment 249390.0 -235000.0 -1.17 196320.0 -197000.0 -0.93 -1.4841 -0.9933 3068009 PK04_095213 Cc1ccc(S[C@@]2(CC(=O)N(Cc3ccccc3)[C@@H]2c4ccc(CO)cc4I)C(=O)O)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 K18 compound treatment 11450.0 -472000.0 -2.36 8080.0 -385000.0 -1.81 -2.9505 -0.9915 3186498 PK04_095214 COc1ccccc1CN2[C@@H](c3ccc(CO)cc3)[C@@](Cc4ccccc4I)(C(=O)NCCCN(C)C)c5ccccc5C2=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 K19 compound treatment 574180.0 90300.0 0.45 598320.0 205000.0 0.96 1.0 0.9402 3068472 PK04_095215 OCc1ccc(cc1)[C@H]2[C@H](C(=O)NCC(F)(F)F)c3ccccc3C(=O)N2Cc4ccccc4Cl 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 K20 compound treatment 577700.0 93800.0 0.47 373090.0 -20400.0 -0.1 0.2633 0.5505 3187259 PK04_095216 COCCCNC(=O)[C@H]1[C@@H](N(C2Cc3ccccc3C2)C(=O)c4ccccc14)c5ccc(CO)cc5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 K21 compound treatment 375870.0 -108000.0 -0.54 512250.0 119000.0 0.56 0.0133 0.0172 3187078 PK04_095217 OCc1ccc(cc1)[C@H]2[C@H](C(=O)NCCN3CCOCC3)c4ccccc4C(=O)N2Cc5ccccc5C(F)(F)F 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 K22 compound treatment 527840.0 43900.0 0.22 356320.0 -37200.0 -0.18 0.0314 0.1119 3068508 PK04_095218 COc1ccccc1CN2[C@H]([C@H](C(=O)NC3CC3)c4ccccc4C2=O)c5ccc(CO)cc5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 K23 mock treatment 530600.0 46700.0 0.23 553760.0 160000.0 0.75 0.6978 0.8846 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 K24 mock treatment 554240.0 70300.0 0.35 554800.0 161000.0 0.76 0.7848 0.9388 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 L01 compound treatment 259810.0 -224000.0 -1.12 197850.0 -196000.0 -0.92 -1.4422 -0.9953 3187175 PK04_095219 COc1ccccc1CN2[C@H]([C@H](C(=O)NCCCN(C)C)c3ccccc3C2=O)c4ccc(CO)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 L02 compound treatment 225360.0 -259000.0 -1.29 186630.0 -207000.0 -0.97 -1.6012 -0.9903 3186714 PK04_095220 CC(C)NC(=O)[C@]1(CC(=O)N(C(C)C)[C@@H]1c2ccc(CO)cc2I)Sc3ccc(C)cc3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 L03 compound treatment 457830.0 -26100.0 -0.13 496480.0 103000.0 0.48 0.2503 0.4992 3067967 PK04_095221 CC(C)N1[C@H](c2ccc(CO)cc2)[C@](CC1=O)(C(=O)NCc3ccccc3)c4ccc(cc4)[N+](=O)[O-] 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 L04 compound treatment 497720.0 13800.0 0.07 211220.0 -182000.0 -0.86 -0.5576 -0.6481 3186429 PK04_095222 CC(C)CN1C(=O)[C@]2(CC(=O)N([C@@H]2c3ccc(CO)cc13)C4CCCCC4)c5ccc(cc5)[N+](=O)[O-] 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 L05 compound treatment 271520.0 -212000.0 -1.06 370470.0 -23100.0 -0.11 -0.8268 -0.7754 3068540 PK04_095223 OCc1ccc(cc1)[C@H]2[C@H](C(=O)NC3CC3)c4ccccc4C(=O)N2C5Cc6ccccc6C5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 L06 compound treatment 492220.0 8320.0 0.04 549280.0 156000.0 0.73 0.5474 0.746 3186551 PK04_095224 CC(C)CNC(=O)[C@]1(Cc2ccccc2I)[C@@H](N(Cc3ccccc3C(F)(F)F)C(=O)c4ccccc41)c5ccc(CO)cc5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 L07 mock treatment 614480.0 131000.0 0.65 456420.0 62900.0 0.3 0.6703 0.936 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 L08 mock treatment 228820.0 -255000.0 -1.27 316180.0 -77400.0 -0.36 -1.1581 -0.8741 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 L09 compound treatment 191900.0 -292000.0 -1.46 217060.0 -176000.0 -0.83 -1.6182 -0.9643 3187518 PK04_095225 CN(C)CCCNC(=O)[C@]1(CC(=O)N(CC2(CC3CC4CC(C3)C2)C4)[C@@H]1c5ccc(CO)cc5)c6ccc(cc6)[N+](=O)[O-] 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 L10 compound treatment 588000.0 104000.0 0.52 208350.0 -185000.0 -0.87 -0.2483 -0.2447 3068144 PK04_095226 COc1ccccc1CN2[C@@H](c3ccc(CO)cc3)[C@@](Cc4ccccc4I)(C(=O)NCc5ccccc5)c6ccccc6C2=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 L11 compound treatment 537090.0 53200.0 0.27 241130.0 -152000.0 -0.72 -0.319 -0.4173 3187076 PK04_095227 COCCCNC(=O)[C@H]1[C@@H](N(Cc2cc(cc(c2)C(F)(F)F)C(F)(F)F)C(=O)c3ccccc13)c4ccc(CO)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 L12 compound treatment 212480.0 -271000.0 -1.36 214720.0 -179000.0 -0.84 -1.5533 -0.9736 3068313 PK04_095228 COCCCNC(=O)[C@]1(CC(=O)N(Cc2ccccc2C(F)(F)F)[C@@H]1c3ccc(CO)cc3I)Sc4ccc(C)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 L13 compound treatment 268430.0 -215000.0 -1.08 203810.0 -190000.0 -0.89 -1.392 -0.9957 3187347 PK04_095229 COc1ccc(CCNC(=O)[C@]2(C)[C@@H](N(C(C)C)C(=O)c3ccccc32)c4ccc(CO)cc4)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 L14 compound treatment 524550.0 40600.0 0.2 517800.0 124000.0 0.58 0.5569 0.9 3068194 PK04_095230 COc1ccccc1CN2[C@@H](c3ccc(CO)cc3)[C@]4(Cc5ccccc5N(CC(C)C)C4=O)c6ccccc6C2=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 L15 mock treatment 605440.0 122000.0 0.61 481510.0 88000.0 0.41 0.7218 0.9826 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 L16 mock treatment 550990.0 67100.0 0.34 599410.0 206000.0 0.97 0.9217 0.8995 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 L17 compound treatment 295200.0 -189000.0 -0.94 551130.0 158000.0 0.74 -0.1423 -0.1186 3068510 PK04_095231 COc1ccccc1CN2[C@H]([C@H](C(=O)NCc3ccccc3)c4ccccc4C2=O)c5ccc(CO)cc5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 L18 compound treatment 196210.0 -288000.0 -1.44 208740.0 -185000.0 -0.87 -1.6306 -0.971 3068263 PK04_095232 COc1ccc(CCNC(=O)[C@]2(CC(=O)N(C(C)C)[C@@H]2c3ccc(CO)cc3I)Sc4ccc(C)cc4)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 L19 compound treatment 472050.0 -11900.0 -0.06 423230.0 29700.0 0.14 0.0569 0.3752 3067958 PK04_095233 OCc1ccc(cc1)[C@H]2N(C3CCCCC3)C(=O)C[C@@]2(C(=O)NCCN4CCOCC4)c5ccc(cc5)[N+](=O)[O-] 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 L20 compound treatment 431900.0 -52000.0 -0.26 491930.0 98400.0 0.46 0.1436 0.2706 3068403 PK04_095234 CN(C)CCCNC(=O)[C@]1(CC(=O)N(Cc2ccccc2C(F)(F)F)[C@@H]1c3ccc(CO)cc3)Sc4ccc(C)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 L21 compound treatment 453960.0 -29900.0 -0.15 420960.0 27400.0 0.13 -0.0145 -0.0735 3187163 PK04_095235 COc1ccc(CCNC(=O)[C@H]2[C@@H](N(Cc3cc(F)cc(c3)C(F)(F)F)C(=O)c4ccccc24)c5ccc(CO)cc5)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 L22 compound treatment 551950.0 68000.0 0.34 253000.0 -141000.0 -0.66 -0.2271 -0.3055 3186433 PK04_095236 OCc1ccc2[C@H]3N(C4CCCCC4)C(=O)C[C@@]3(C(=O)N(CC(F)(F)F)c2c1)c5ccc(cc5)[N+](=O)[O-] 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 L23 mock treatment 585380.0 101000.0 0.51 435570.0 42000.0 0.2 0.4982 0.9157 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 L24 mock treatment 497760.0 13900.0 0.07 417490.0 24000.0 0.11 0.1286 0.9726 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 M01 compound treatment 543700.0 59800.0 0.3 422780.0 29200.0 0.14 0.3085 0.9381 3187444 PK04_095237 CC(C)CNC(=O)[C@]1(CC(=O)N(C(C)C)[C@@H]1c2ccc(CO)cc2)c3ccc(cc3)[N+](=O)[O-] 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 M02 compound treatment 522310.0 38400.0 0.19 548800.0 155000.0 0.73 0.6521 0.8636 3068593 PK04_095238 CC(C)N1[C@@H](c2ccc(CO)cc2)[C@@](C)(C(=O)NC3CC3)c4ccccc4C1=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 M03 compound treatment 236390.0 -248000.0 -1.24 260970.0 -133000.0 -0.62 -1.315 -0.9498 3187441 PK04_095239 CC(C)NC(=O)[C@]1(CC(=O)N([C@@H]1c2ccc(CO)cc2)C3CCCCC3)c4ccc(cc4)[N+](=O)[O-] 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 M04 compound treatment 317600.0 -166000.0 -0.83 541920.0 148000.0 0.7 -0.0938 -0.0864 3068649 PK04_095240 COCCCNC(=O)[C@]1(C)[C@@H](N(Cc2cc(cc(c2)C(F)(F)F)C(F)(F)F)C(=O)c3ccccc31)c4ccc(CO)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 M05 compound treatment 138460.0 -345000.0 -1.73 109710.0 -284000.0 -1.34 -2.164 -0.992 3068152 PK04_095241 CN(C)CCCNC(=O)[C@]1(Cc2ccccc2I)[C@@H](N(Cc3ccccc3C(F)(F)F)C(=O)c4ccccc41)c5ccc(CO)cc5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 M06 compound treatment 493600.0 9700.0 0.05 365570.0 -28000.0 -0.13 -0.0587 -0.4191 3068655 PK04_095242 C[C@]1([C@@H](N(Cc2ccccc2)C(=O)c3ccccc31)c4ccc(CO)cc4)C(=O)NCC(F)(F)F 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 M07 compound treatment 441000.0 -42900.0 -0.21 485070.0 91500.0 0.43 0.1529 0.318 3068005 PK04_095243 Cc1ccc(S[C@@]2(CC(=O)N(Cc3ccccc3C(F)(F)F)[C@@H]2c4ccc(CO)cc4)C(=O)O)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 M08 compound treatment 290370.0 -194000.0 -0.97 208040.0 -185000.0 -0.87 -1.3004 -0.9987 3187084 PK04_095244 OCc1ccc(cc1)[C@H]2[C@H](C(=O)NCCN3CCOCC3)c4ccccc4C(=O)N2Cc5ccccc5Cl 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 M09 mock treatment 554150.0 70200.0 0.35 505040.0 112000.0 0.52 0.619 0.9809 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 M10 mock treatment 619220.0 135000.0 0.68 537250.0 144000.0 0.68 0.9559 1.0 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 M11 compound treatment 298000.0 -186000.0 -0.93 177920.0 -216000.0 -1.01 -1.3737 -0.999 3186422 PK04_095245 CCCNC(=O)[C@]1(CC(=O)N(CC2(CC3CC4CC(C3)C2)C4)[C@@H]1c5ccc(CO)cc5I)c6ccc(cc6)[N+](=O)[O-] 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 M12 compound treatment 30890.0 -453000.0 -2.26 9040.0 -384000.0 -1.81 -2.8787 -0.9938 3068142 PK04_095246 CN(C)CCCNC(=O)[C@]1(Cc2ccccc2I)[C@@H](N(C3CCCCC3)C(=O)c4ccccc41)c5ccc(CO)cc5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 M13 mock treatment 348550.0 -135000.0 -0.68 473300.0 79800.0 0.38 -0.2127 -0.2751 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 M14 mock treatment 542080.0 58200.0 0.29 239470.0 -154000.0 -0.72 -0.3069 -0.3931 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 M15 compound treatment 268260.0 -216000.0 -1.08 239940.0 -154000.0 -0.72 -1.2724 -0.9811 3068557 PK04_095247 OCc1ccc(cc1)[C@H]2[C@H](C(=O)NCc3ccccc3)c4ccccc4C(=O)N2C5CCCCC5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 M16 compound treatment 570300.0 86400.0 0.43 298610.0 -94900.0 -0.45 -0.0106 -0.017 3187170 PK04_095248 CCCNC(=O)[C@H]1[C@@H](N(Cc2ccccc2OC)C(=O)c3ccccc13)c4ccc(CO)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 M17 compound treatment 569320.0 85400.0 0.43 538350.0 145000.0 0.68 0.7833 0.9746 3187431 PK04_095249 CC(C)NC(=O)[C@]1(C)[C@@H](N(Cc2cc(cc(c2)C(F)(F)F)C(F)(F)F)C(=O)c3ccccc31)c4ccc(CO)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 M18 compound treatment 542210.0 58300.0 0.29 551640.0 158000.0 0.74 0.7318 0.9163 3187074 PK04_095250 OCc1ccc(cc1)[C@H]2[C@H](C(=O)NCCN3CCOCC3)c4ccccc4C(=O)N2Cc5cc(cc(c5)C(F)(F)F)C(F)(F)F 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 M19 compound treatment 323840.0 -160000.0 -0.8 494470.0 101000.0 0.47 -0.2296 -0.2469 3068552 PK04_095251 CC(C)NC(=O)[C@H]1[C@@H](N(C(C)C)C(=O)c2ccccc12)c3ccc(CO)cc3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 M20 compound treatment 276590.0 -207000.0 -1.04 256800.0 -137000.0 -0.64 -1.1869 -0.9738 3068014 PK04_095252 COc1ccccc1CN2[C@@H](c3ccc(CO)cc3)[C@@](Cc4ccccc4I)(C(=O)O)c5ccccc5C2=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 M21 compound treatment 510420.0 26500.0 0.13 499080.0 106000.0 0.5 0.4447 0.8655 3187086 PK04_095253 CC(C)NC(=O)[C@H]1[C@@H](N(Cc2ccccc2Cl)C(=O)c3ccccc13)c4ccc(CO)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 M22 compound treatment 521180.0 37300.0 0.19 417020.0 23500.0 0.11 0.2098 0.9689 3187428 PK04_095254 C[C@]1([C@@H](N(Cc2cc(cc(c2)C(F)(F)F)C(F)(F)F)C(=O)c3ccccc31)c4ccc(CO)cc4)C(=O)NC5CC5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 M23 compound treatment 470340.0 -13600.0 -0.07 448980.0 55400.0 0.26 0.1365 0.5067 3187081 PK04_095255 CN(C)CCCNC(=O)[C@H]1[C@@H](N(Cc2ccccc2C(F)(F)F)C(=O)c3ccccc13)c4ccc(CO)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 M24 compound treatment 433000.0 -50900.0 -0.25 401940.0 8410.0 0.04 -0.1518 -0.59 3068003 PK04_095256 Cc1ccc(S[C@@]2(CC(=O)N(Cc3ccccc3)[C@@H]2c4ccc(CO)cc4)C(=O)O)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 N01 compound treatment 517150.0 33200.0 0.17 189290.0 -204000.0 -0.96 -0.5619 -0.5763 3187360 PK04_095257 C[C@]1([C@@H](N(Cc2ccc(OC(F)(F)F)cc2)C(=O)c3ccccc31)c4ccc(CO)cc4)C(=O)NCc5ccccc5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 N02 compound treatment 549210.0 65300.0 0.33 188240.0 -205000.0 -0.97 -0.4522 -0.4436 3068231 PK04_095258 OCc1ccc(cc1)[C@@H]2N(Cc3ccccc3)C(=O)c4ccccc4[C@]52Cc6ccccc6N(CCN7CCOCC7)C5=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 N03 compound treatment 491390.0 7490.0 0.04 519160.0 126000.0 0.59 0.4443 0.7504 3068544 PK04_095259 CC(C)NC(=O)[C@H]1[C@@H](N(C2Cc3ccccc3C2)C(=O)c4ccccc14)c5ccc(CO)cc5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 N04 compound treatment 202770.0 -281000.0 -1.4 158320.0 -235000.0 -1.11 -1.7752 -0.993 3187527 PK04_095260 OCc1ccc(cc1)[C@H]2N(CC3(CC4CC5CC(C4)C3)C5)C(=O)C[C@@]2(C(=O)O)c6ccc(cc6)[N+](=O)[O-] 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 N05 compound treatment 524330.0 40400.0 0.2 181610.0 -212000.0 -1.0 -0.5621 -0.5526 3187260 PK04_095261 CCCNC(=O)[C@H]1[C@@H](N(C(C)C)C(=O)c2ccccc12)c3ccc(CO)cc3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 N06 compound treatment 137330.0 -347000.0 -1.73 206270.0 -187000.0 -0.88 -1.8468 -0.9509 3186724 PK04_095262 Cc1ccc(S[C@@]2(CC(=O)N(Cc3ccccc3Cl)[C@@H]2c4ccc(CO)cc4I)C(=O)NC5CC5)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 N07 compound treatment 475530.0 -8370.0 -0.04 281250.0 -112000.0 -0.53 -0.403 -0.7607 3068501 PK04_095263 CCCNC(=O)[C@H]1[C@@H](N(Cc2ccc(OC(F)(F)F)cc2)C(=O)c3ccccc13)c4ccc(CO)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 N08 compound treatment 364810.0 -119000.0 -0.59 218880.0 -175000.0 -0.82 -1.0015 -0.9874 3186871 PK04_095264 Cc1ccc(S[C@@]2(CC(=O)N([C@@H]2c3ccc(CO)cc3)C4CCCCC4)C(=O)NCC(F)(F)F)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 N09 mock treatment 547240.0 63300.0 0.32 259400.0 -134000.0 -0.63 -0.2224 -0.3152 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 N10 mock treatment 298980.0 -185000.0 -0.92 306770.0 -86800.0 -0.41 -0.9416 -0.9326 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 N11 compound treatment 396750.0 -87200.0 -0.44 206990.0 -187000.0 -0.88 -0.9282 -0.9477 3187070 PK04_095265 OCc1ccc(cc1)[C@H]2[C@H](C(=O)NCC(F)(F)F)c3ccccc3C(=O)N2Cc4ccccc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 N12 compound treatment 199320.0 -285000.0 -1.42 133800.0 -260000.0 -1.22 -1.8689 -0.9972 3186804 PK04_095266 CC(C)NC(=O)[C@]1(CC(=O)N(Cc2ccccc2)[C@@H]1c3ccc(CO)cc3I)Sc4ccc(C)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 N13 mock treatment 274270.0 -210000.0 -1.05 426340.0 32800.0 0.15 -0.6312 -0.5964 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 N14 mock treatment 371470.0 -112000.0 -0.56 268380.0 -125000.0 -0.59 -0.8133 -0.9997 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 N15 compound treatment 138040.0 -346000.0 -1.73 105310.0 -288000.0 -1.36 -2.1801 -0.9928 3186424 PK04_095267 OCc1ccc([C@H]2N(CC3(CC4CC5CC(C4)C3)C5)C(=O)C[C@@]2(C(=O)NCCN6CCOCC6)c7ccc(cc7)[N+](=O)[O-])c(I)c1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 N16 compound treatment 263680.0 -220000.0 -1.1 397620.0 4090.0 0.02 -0.7641 -0.6946 3068226 PK04_095268 OCc1ccc(cc1)[C@@H]2N(Cc3ccccc3C(F)(F)F)C(=O)c4ccccc4[C@]52Cc6ccccc6N(Cc7ccccc7)C5=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 N17 compound treatment 493130.0 9230.0 0.05 476250.0 82700.0 0.39 0.3077 0.7854 3068455 PK04_095269 COc1ccc(CCNC(=O)[C@H]2[C@@H](N(Cc3cc(cc(c3)C(F)(F)F)C(F)(F)F)C(=O)c4ccccc24)c5ccc(CO)cc5)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 N18 compound treatment 292960.0 -191000.0 -0.95 221440.0 -172000.0 -0.81 -1.2467 -0.9967 3068137 PK04_095270 CN(C)CCCN1C(=O)[C@]2(CC(=O)N(CC3(CC4CC5CC(C4)C3)C5)[C@@H]2c6ccc(CO)cc16)c7ccc(cc7)[N+](=O)[O-] 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 N19 compound treatment 500530.0 16600.0 0.08 517280.0 124000.0 0.58 0.4703 0.7999 3068647 PK04_095271 C[C@]1([C@@H](N(Cc2cc(cc(c2)C(F)(F)F)C(F)(F)F)C(=O)c3ccccc31)c4ccc(CO)cc4)C(=O)NCC(F)(F)F 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 N20 compound treatment 227210.0 -257000.0 -1.28 162780.0 -231000.0 -1.09 -1.674 -0.9966 3186492 PK04_095272 OCc1ccc(cc1)[C@@H]2N(C3CCCCC3)C(=O)c4ccccc4[C@]2(Cc5ccccc5I)C(=O)NCC(F)(F)F 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 N21 compound treatment 285440.0 -198000.0 -0.99 202080.0 -191000.0 -0.9 -1.3377 -0.9989 3067959 PK04_095273 COc1ccc(CCNC(=O)[C@]2(CC(=O)N([C@@H]2c3ccc(CO)cc3)C4CCCCC4)c5ccc(cc5)[N+](=O)[O-])cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 N22 compound treatment 393550.0 -90400.0 -0.45 303630.0 -89900.0 -0.42 -0.6181 -0.9995 3187526 PK04_095274 CC(C)N1[C@H](c2ccc(CO)cc2)[C@](CC1=O)(C(=O)O)c3ccc(cc3)[N+](=O)[O-] 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 N23 compound treatment 447800.0 -36100.0 -0.18 438940.0 45400.0 0.21 0.0235 0.0842 3068468 PK04_095275 CCCNC(=O)[C@H]1[C@@H](N(Cc2ccccc2Cl)C(=O)c3ccccc13)c4ccc(CO)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 N24 compound treatment 427090.0 -56800.0 -0.28 475410.0 81900.0 0.39 0.0717 0.1499 3068222 PK04_095276 COCCCN1C(=O)[C@]2(Cc3ccccc13)[C@@H](N(Cc4ccccc4Cl)C(=O)c5ccccc52)c6ccc(CO)cc6 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 O01 compound treatment 203720.0 -280000.0 -1.4 210940.0 -183000.0 -0.86 -1.5968 -0.9725 3068590 PK04_095277 CC(C)NC(=O)[C@H]1[C@@H](N(CC2(CC3CC4CC(C3)C2)C4)C(=O)c5ccccc15)c6ccc(CO)cc6 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 O02 compound treatment 190530.0 -293000.0 -1.47 105860.0 -288000.0 -1.35 -1.9929 -0.9992 3067977 PK04_095278 COCCCNC(=O)[C@]1(CC(=O)N(CC2(CC3CC4CC(C3)C2)C4)[C@@H]1c5ccc(CO)cc5)c6ccc(cc6)[N+](=O)[O-] 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 O03 compound treatment 307890.0 -176000.0 -0.88 434280.0 40700.0 0.19 -0.4861 -0.5403 3068512 PK04_095279 COc1ccccc1CN2[C@H]([C@H](C(=O)NCC(F)(F)F)c3ccccc3C2=O)c4ccc(CO)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 O04 compound treatment 353610.0 -130000.0 -0.65 239840.0 -154000.0 -0.72 -0.9713 -0.9986 3068637 PK04_095280 C[C@]1([C@@H](N(Cc2cc(F)cc(c2)C(F)(F)F)C(=O)c3ccccc31)c4ccc(CO)cc4)C(=O)NCCN5CCOCC5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 O05 compound treatment 557440.0 73500.0 0.37 551800.0 158000.0 0.74 0.7861 0.947 3068459 PK04_095281 OCc1ccc(cc1)[C@H]2[C@H](C(=O)NCC(F)(F)F)c3ccccc3C(=O)N2Cc4cc(cc(c4)C(F)(F)F)C(F)(F)F 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 O06 compound treatment 492230.0 8330.0 0.04 491090.0 97600.0 0.46 0.3539 0.7681 3187520 PK04_095282 Cc1ccc(S[C@@]2(CC(=O)N([C@@H]2c3ccc(CO)cc3)C4CCCCC4)C(=O)O)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 O07 compound treatment 536960.0 53100.0 0.27 424450.0 30900.0 0.15 0.2902 0.9601 3186989 PK04_095283 OCc1ccc(cc1)[C@H]2[C@H](C(=O)NC3CC3)c4ccccc4C(=O)N2Cc5ccccc5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 O08 compound treatment 258560.0 -225000.0 -1.13 436040.0 42500.0 0.2 -0.6544 -0.5725 3187364 PK04_095284 C[C@]1([C@@H](N(Cc2cc(F)cc(c2)C(F)(F)F)C(=O)c3ccccc31)c4ccc(CO)cc4)C(=O)NCc5ccccc5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 O09 compound treatment 473850.0 -10100.0 -0.05 503810.0 110000.0 0.52 0.3313 0.6357 3068604 PK04_095285 CCCNC(=O)[C@]1(C)[C@@H](N(Cc2ccc(OC(F)(F)F)cc2)C(=O)c3ccccc31)c4ccc(CO)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 O10 compound treatment 490620.0 6720.0 0.03 497460.0 104000.0 0.49 0.3694 0.7539 3187362 PK04_095286 COCCCNC(=O)[C@]1(C)[C@@H](N(Cc2ccc(OC(F)(F)F)cc2)C(=O)c3ccccc31)c4ccc(CO)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 O11 mock treatment 577500.0 93600.0 0.47 401350.0 7820.0 0.04 0.3566 0.7604 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 O12 mock treatment 333120.0 -151000.0 -0.75 586160.0 193000.0 0.91 0.1082 0.0918 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 O13 compound treatment 528750.0 44800.0 0.22 550100.0 157000.0 0.74 0.6791 0.8823 3068644 PK04_095287 CC(C)CNC(=O)[C@]1(C)[C@@H](N(Cc2cc(cc(c2)C(F)(F)F)C(F)(F)F)C(=O)c3ccccc31)c4ccc(CO)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 O14 compound treatment 551640.0 67700.0 0.34 288160.0 -105000.0 -0.5 -0.1112 -0.1854 3068464 PK04_095288 OCc1ccc(cc1)[C@H]2[C@H](C(=O)NCc3ccccc3)c4ccccc4C(=O)N2Cc5ccccc5C(F)(F)F 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 O15 compound treatment 127000.0 -357000.0 -1.78 119790.0 -274000.0 -1.29 -2.1709 -0.9873 3187516 PK04_095289 OCc1ccc(cc1)[C@H]2N(CC3(CC4CC5CC(C4)C3)C5)C(=O)C[C@@]2(C(=O)NCc6ccccc6)c7ccc(cc7)[N+](=O)[O-] 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 O16 compound treatment 452080.0 -31800.0 -0.16 233810.0 -160000.0 -0.75 -0.6436 -0.8381 3187164 PK04_095290 OCc1ccc(cc1)[C@H]2[C@H](C(=O)NCc3ccccc3)c4ccccc4C(=O)N2Cc5cc(F)cc(c5)C(F)(F)F 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 O17 compound treatment 295370.0 -189000.0 -0.94 536840.0 143000.0 0.67 -0.1892 -0.1634 3187177 PK04_095291 CC(C)CNC(=O)[C@H]1[C@@H](N(C(=O)c2ccccc12)c3ccc(C)cn3)c4ccc(CO)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 O18 compound treatment 310110.0 -174000.0 -0.87 158520.0 -235000.0 -1.11 -1.3954 -0.9928 3068546 PK04_095292 CN(C)CCCNC(=O)[C@H]1[C@@H](N(C2Cc3ccccc3C2)C(=O)c4ccccc14)c5ccc(CO)cc5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 O19 compound treatment 432010.0 -51900.0 -0.26 399840.0 6310.0 0.03 -0.1623 -0.6221 3187256 PK04_095293 CC(C)CNC(=O)[C@H]1[C@@H](N(C2Cc3ccccc3C2)C(=O)c4ccccc14)c5ccc(CO)cc5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 O20 compound treatment 291220.0 -193000.0 -0.96 275690.0 -118000.0 -0.55 -1.0724 -0.9657 3187088 PK04_095294 COCCCNC(=O)[C@H]1[C@@H](N(Cc2ccccc2Cl)C(=O)c3ccccc13)c4ccc(CO)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 O21 compound treatment 423680.0 -60200.0 -0.3 409600.0 16100.0 0.08 -0.1592 -0.5135 3186494 PK04_095295 COc1ccccc1CN2[C@@H](c3ccc(CO)cc3)[C@@](Cc4ccccc4I)(C(=O)NCC(C)C)c5ccccc5C2=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 O22 compound treatment 525290.0 41400.0 0.21 333920.0 -59600.0 -0.28 -0.0521 -0.1496 3187161 PK04_095296 CC(C)CNC(=O)[C@H]1[C@@H](N(Cc2cc(F)cc(c2)C(F)(F)F)C(=O)c3ccccc13)c4ccc(CO)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 O23 compound treatment 361970.0 -122000.0 -0.61 377870.0 -15700.0 -0.07 -0.4827 -0.7869 3187267 PK04_095297 CC(C)CNC(=O)[C@H]1[C@@H](N(C2CCCCC2)C(=O)c3ccccc13)c4ccc(CO)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 O24 compound treatment 486850.0 2950.0 0.01 526180.0 133000.0 0.62 0.4516 0.7236 3068502 PK04_095298 CC(C)CNC(=O)[C@H]1[C@@H](N(Cc2ccc(OC(F)(F)F)cc2)C(=O)c3ccccc13)c4ccc(CO)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 P01 compound treatment 434400.0 -49500.0 -0.25 144640.0 -249000.0 -1.17 -1.0026 -0.838 3068591 PK04_095299 OCc1ccc(cc1)[C@H]2[C@H](C(=O)NCC(F)(F)F)c3ccccc3C(=O)N2CC4(CC5CC6CC(C5)C4)C6 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 P02 compound treatment 471040.0 -12900.0 -0.06 145890.0 -248000.0 -1.16 -0.8691 -0.745 3187521 PK04_095300 CC(C)N1[C@H](c2ccc(CO)cc2)[C@@](CC1=O)(Sc3ccc(C)cc3)C(=O)O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 P03 compound treatment 179790.0 -304000.0 -1.52 170020.0 -224000.0 -1.05 -1.8174 -0.9839 3186990 PK04_095301 COc1ccc(CCNC(=O)[C@H]2[C@@H](N(Cc3ccccc3)C(=O)c4ccccc24)c5ccc(CO)cc5)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 P04 compound treatment 178110.0 -306000.0 -1.53 150240.0 -243000.0 -1.14 -1.8891 -0.9899 3186985 PK04_095302 CC(C)NC(=O)[C@]1(CC(=O)N(Cc2ccccc2)[C@@H]1c3ccc(CO)cc3)Sc4ccc(C)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 P05 compound treatment 108640.0 -375000.0 -1.87 102240.0 -291000.0 -1.37 -2.2941 -0.9881 3067579 PK04_095303 OCc1ccc([C@H]2N(CC3(CC4CC5CC(C4)C3)C5)C(=O)C[C@@]2(C(=O)NCC(F)(F)F)c6ccc(cc6)[N+](=O)[O-])c(I)c1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 P06 compound treatment 173500.0 -310000.0 -1.55 221060.0 -172000.0 -0.81 -1.6699 -0.9544 3186975 PK04_095304 Cc1ccc(S[C@@]2(CC(=O)N(Cc3ccccc3C(F)(F)F)[C@@H]2c4ccc(CO)cc4)C(=O)NCc5ccccc5)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 P07 compound treatment 297970.0 -186000.0 -0.93 172020.0 -222000.0 -1.04 -1.3934 -0.9984 3068548 PK04_095305 CC(C)CNC(=O)[C@H]1[C@@H](N(C(C)C)C(=O)c2ccccc12)c3ccc(CO)cc3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 P08 compound treatment 191230.0 -293000.0 -1.46 161780.0 -232000.0 -1.09 -1.8044 -0.9896 3067563 PK04_095306 OCc1ccc2[C@H]3N(C4CCCCC4)C(=O)C[C@@]3(C(=O)N(CCN5CCOCC5)c2c1)c6ccc(cc6)[N+](=O)[O-] 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 P09 compound treatment 224590.0 -259000.0 -1.3 169220.0 -224000.0 -1.06 -1.6619 -0.9948 3067961 PK04_095307 OCc1ccc(cc1)[C@H]2N(C3CCCCC3)C(=O)C[C@@]2(C(=O)NCc4ccccc4)c5ccc(cc5)[N+](=O)[O-] 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 P10 compound treatment 200730.0 -283000.0 -1.41 178600.0 -215000.0 -1.01 -1.7149 -0.9865 3068015 PK04_095308 OCc1ccc(cc1)[C@@H]2N(Cc3ccccc3)C(=O)c4ccccc4[C@]2(Cc5ccccc5I)C(=O)O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 P11 mock treatment 336420.0 -147000.0 -0.74 197090.0 -196000.0 -0.92 -1.1742 -0.9937 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 P12 mock treatment 158930.0 -325000.0 -1.62 131280.0 -262000.0 -1.23 -2.0199 -0.9908 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 P13 compound treatment 262400.0 -222000.0 -1.11 174270.0 -219000.0 -1.03 -1.5115 -0.9994 3187510 PK04_095309 CC(C)NC(=O)[C@]1(CC(=O)N(C(C)C)[C@@H]1c2ccc(CO)cc2)c3ccc(cc3)[N+](=O)[O-] 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 P14 compound treatment 121980.0 -362000.0 -1.81 118880.0 -275000.0 -1.29 -2.1917 -0.9864 3186495 PK04_095310 COc1ccccc1CN2[C@@H](c3ccc(CO)cc3)[C@@](Cc4ccccc4I)(C(=O)NCCN5CCOCC5)c6ccccc6C2=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 P15 compound treatment 326180.0 -158000.0 -0.79 211730.0 -182000.0 -0.86 -1.1617 -0.9992 3187437 PK04_095311 CC(C)NC(=O)[C@]1(C)[C@@H](N(Cc2ccccc2)C(=O)c3ccccc31)c4ccc(CO)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 P16 compound treatment 279910.0 -204000.0 -1.02 387790.0 -5740.0 -0.03 -0.7395 -0.7256 3186625 PK04_095312 COc1ccccc1CN2[C@@H](c3ccc(CO)cc3)[C@]4(Cc5ccccc5N(C(C)C)C4=O)c6ccccc6C2=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 P17 compound treatment 248840.0 -235000.0 -1.17 303520.0 -90000.0 -0.42 -1.1295 -0.9051 3068541 PK04_095313 OCc1ccc(cc1)[C@H]2[C@H](C(=O)NCCN3CCOCC3)c4ccccc4C(=O)N2C5Cc6ccccc6C5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 P18 compound treatment 231680.0 -252000.0 -1.26 212730.0 -181000.0 -0.85 -1.4921 -0.9817 3186878 PK04_095314 Cc1ccc(S[C@@]2(CC(=O)N(C3Cc4ccccc4C3)[C@@H]2c5ccc(CO)cc5)C(=O)NC6CC6)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 P19 compound treatment 98690.0 -385000.0 -1.92 122100.0 -271000.0 -1.28 -2.2632 -0.9802 3187513 PK04_095315 CC(C)CNC(=O)[C@]1(CC(=O)N(CC2(CC3CC4CC(C3)C2)C4)[C@@H]1c5ccc(CO)cc5)c6ccc(cc6)[N+](=O)[O-] 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 P20 compound treatment 178080.0 -306000.0 -1.53 177460.0 -216000.0 -1.02 -1.7987 -0.9804 3068271 PK04_095316 Cc1ccc(S[C@@]2(CC(=O)N(C3Cc4ccccc4C3)[C@@H]2c5ccc(CO)cc5I)C(=O)NCc6ccccc6)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 P21 compound treatment 171300.0 -313000.0 -1.56 184290.0 -209000.0 -0.98 -1.7999 -0.9753 3068008 PK04_095317 CC(C)N1[C@H](c2ccc(CO)cc2I)[C@@](CC1=O)(Sc3ccc(C)cc3)C(=O)O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 P22 compound treatment 146900.0 -337000.0 -1.68 132560.0 -261000.0 -1.23 -2.0582 -0.988 3068262 PK04_095318 CC(C)N1[C@H](c2ccc(CO)cc2I)[C@@](CC1=O)(Sc3ccc(C)cc3)C(=O)NCCN4CCOCC4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 P23 compound treatment 430990.0 -52900.0 -0.26 318240.0 -75300.0 -0.35 -0.4373 -0.9896 3068469 PK04_095319 OCc1ccc(cc1)[C@H]2[C@H](C(=O)NC3CC3)c4ccccc4C(=O)N2Cc5ccccc5Cl 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2095 P24 compound treatment 159240.0 -325000.0 -1.62 179210.0 -214000.0 -1.01 -1.8594 -0.9739 3186794 PK04_095320 CCCNC(=O)[C@]1(CC(=O)N(Cc2cc(cc(c2)C(F)(F)F)C(F)(F)F)[C@@H]1c3ccc(CO)cc3I)Sc4ccc(C)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 A01 compound treatment 168480.0 -209000.0 -1.04 182920.0 -170000.0 -0.8 -1.3029 -0.9914 3186490 PK04_096001 COc1ccc(CCNC(=O)[C@]2(Cc3ccccc3I)[C@@H](N(C4CCCCC4)C(=O)c5ccccc52)c6ccc(CO)cc6)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 A02 compound treatment 475970.0 98700.0 0.49 454820.0 102000.0 0.48 0.6874 0.9999 3186641 PK04_096002 CN(C)CCCN1C(=O)[C@]2(Cc3ccccc13)[C@@H](N(Cc4ccccc4)C(=O)c5ccccc52)c6ccc(CO)cc6 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 A03 compound treatment 208980.0 -168000.0 -0.84 132480.0 -220000.0 -1.04 -1.3276 -0.9946 3068261 PK04_096003 CC(C)N1[C@H](c2ccc(CO)cc2I)[C@@](CC1=O)(Sc3ccc(C)cc3)C(=O)NC4CC4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 A04 compound treatment 184580.0 -193000.0 -0.96 199880.0 -153000.0 -0.72 -1.1896 -0.9897 3186971 PK04_096004 COCCCNC(=O)[C@]1(CC(=O)N(Cc2ccccc2Cl)[C@@H]1c3ccc(CO)cc3)Sc4ccc(C)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 A05 compound treatment 164430.0 -213000.0 -1.06 173080.0 -180000.0 -0.85 -1.3499 -0.9936 3186883 PK04_096005 COCCCNC(=O)[C@]1(CC(=O)N(C2Cc3ccccc3C2)[C@@H]1c4ccc(CO)cc4)Sc5ccc(C)cc5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 A06 compound treatment 216800.0 -161000.0 -0.8 253150.0 -99700.0 -0.47 -0.8987 -0.9674 3068309 PK04_096006 CC(C)NC(=O)[C@]1(CC(=O)N(Cc2ccccc2C(F)(F)F)[C@@H]1c3ccc(CO)cc3I)Sc4ccc(C)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 A07 compound treatment 111080.0 -266000.0 -1.33 190790.0 -162000.0 -0.76 -1.4794 -0.9652 3186716 PK04_096007 COCCCNC(=O)[C@]1(CC(=O)N(C(C)C)[C@@H]1c2ccc(CO)cc2I)Sc3ccc(C)cc3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 A08 compound treatment 300350.0 -77000.0 -0.38 392200.0 39300.0 0.18 -0.1411 -0.3308 3068367 PK04_096008 COc1ccc(CCNC(=O)[C@]2(CC(=O)N(C3Cc4ccccc4C3)[C@@H]2c5ccc(CO)cc5)Sc6ccc(C)cc6)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 A09 compound treatment 178250.0 -199000.0 -0.99 188850.0 -164000.0 -0.77 -1.2487 -0.9921 3068224 PK04_096009 OCc1ccc(cc1)[C@@H]2N(Cc3ccccc3C(F)(F)F)C(=O)c4ccccc4[C@]52Cc6ccccc6N(C7CC7)C5=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 A10 compound treatment 205180.0 -172000.0 -0.86 180520.0 -172000.0 -0.81 -1.1813 -0.9996 3186633 PK04_096010 COc1ccc(CCN2C(=O)[C@]3(Cc4ccccc24)[C@@H](N(Cc5ccccc5C(F)(F)F)C(=O)c6ccccc63)c7ccc(CO)cc7)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 A11 compound treatment 400430.0 23100.0 0.12 463710.0 111000.0 0.52 0.4502 0.8433 3186986 PK04_096011 Cc1ccc(S[C@@]2(CC(=O)N(Cc3ccccc3)[C@@H]2c4ccc(CO)cc4)C(=O)NCC(F)(F)F)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 A12 compound treatment 185640.0 -192000.0 -0.96 166280.0 -187000.0 -0.88 -1.2976 -0.9991 3186640 PK04_096012 OCc1ccc(cc1)[C@@H]2N(Cc3ccccc3)C(=O)c4ccccc4[C@]52Cc6ccccc6N(CC(F)(F)F)C5=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 A13 mock treatment 265930.0 -111000.0 -0.56 205760.0 -147000.0 -0.69 -0.8828 -0.9941 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 A14 mock treatment 213570.0 -164000.0 -0.82 195710.0 -157000.0 -0.74 -1.1011 -0.9987 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 A15 compound treatment 286720.0 -90600.0 -0.45 170800.0 -182000.0 -0.86 -0.9256 -0.9555 3186881 PK04_096013 CC(C)NC(=O)[C@]1(CC(=O)N(C2Cc3ccccc3C2)[C@@H]1c4ccc(CO)cc4)Sc5ccc(C)cc5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 A16 compound treatment 213010.0 -164000.0 -0.82 203620.0 -149000.0 -0.7 -1.0768 -0.997 3186790 PK04_096014 CCCNC(=O)[C@]1(CC(=O)N(Cc2ccccc2C(F)(F)F)[C@@H]1c3ccc(CO)cc3I)Sc4ccc(C)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 A17 compound treatment 487890.0 111000.0 0.55 355230.0 2330.0 0.01 0.3983 0.721 3186485 PK04_096015 CC(C)CN1C(=O)[C@]2(CC(=O)N(CC3(CC4CC5CC(C4)C3)C5)[C@@H]2c6ccc(CO)cc16)c7ccc(cc7)[N+](=O)[O-] 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 A18 compound treatment 208060.0 -169000.0 -0.85 192800.0 -160000.0 -0.75 -1.1302 -0.9983 3186802 PK04_096016 Cc1ccc(S[C@@]2(CC(=O)N(Cc3ccccc3)[C@@H]2c4ccc(CO)cc4I)C(=O)NCCN5CCOCC5)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 A19 compound treatment 414680.0 37400.0 0.19 415870.0 63000.0 0.3 0.3414 0.9752 3068405 PK04_096017 CCCNC(=O)[C@]1(CC(=O)N(Cc2cc(cc(c2)C(F)(F)F)C(F)(F)F)[C@@H]1c3ccc(CO)cc3)Sc4ccc(C)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 A20 compound treatment 461840.0 84500.0 0.42 258800.0 -94100.0 -0.44 -0.0145 -0.0237 3068141 PK04_096018 OCc1ccc(cc1)[C@@H]2N(C3CCCCC3)C(=O)c4ccccc4[C@]2(Cc5ccccc5I)C(=O)NCc6ccccc6 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 A21 compound treatment 363880.0 -13400.0 -0.07 164480.0 -188000.0 -0.89 -0.6741 -0.7585 3186624 PK04_096019 COc1ccc(CCN2C(=O)[C@]3(Cc4ccccc24)[C@@H](N(Cc5ccccc5OC)C(=O)c6ccccc63)c7ccc(CO)cc7)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 A22 compound treatment 251550.0 -126000.0 -0.63 184250.0 -169000.0 -0.79 -1.0051 -0.9933 3068200 PK04_096020 COc1ccccc1CN2[C@@H](c3ccc(CO)cc3)[C@]4(Cc5ccccc5N(CCCN(C)C)C4=O)c6ccccc6C2=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 A23 compound treatment 237120.0 -140000.0 -0.7 249300.0 -104000.0 -0.49 -0.8397 -0.9843 3068358 PK04_096021 CC(C)CNC(=O)[C@]1(CC(=O)N(C(C)C)[C@@H]1c2ccc(CO)cc2)Sc3ccc(C)cc3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 A24 compound treatment 279620.0 -97700.0 -0.49 172970.0 -180000.0 -0.85 -0.9435 -0.9658 3068371 PK04_096022 CCCNC(=O)[C@]1(CC(=O)N(Cc2ccccc2Cl)[C@@H]1c3ccc(CO)cc3)Sc4ccc(C)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 B01 compound treatment 482440.0 105000.0 0.53 509140.0 156000.0 0.73 0.8909 0.9864 3187511 PK04_096023 CC(C)N1[C@H](c2ccc(CO)cc2)[C@](CC1=O)(C(=O)NCC(F)(F)F)c3ccc(cc3)[N+](=O)[O-] 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 B02 compound treatment 527910.0 151000.0 0.75 494470.0 142000.0 0.67 1.0027 0.9982 3187030 PK04_096024 OCCCc1cc[n+](Cc2cccc(OC(F)(F)F)c2)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 B03 compound treatment 207480.0 -170000.0 -0.85 415970.0 63100.0 0.3 -0.39 -0.434 3187169 PK04_096025 CN(C)CCCNC(=O)[C@H]1[C@@H](N(Cc2ccc(OC(F)(F)F)cc2)C(=O)c3ccccc13)c4ccc(CO)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 B04 compound treatment 468290.0 91000.0 0.45 462010.0 109000.0 0.51 0.6842 0.9982 3068853 PK04_096026 COc1cc2CCN(Cc3cccc(OC(F)(F)F)c3)C(C)c2cc1O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 B05 compound treatment 524110.0 147000.0 0.73 502330.0 149000.0 0.7 1.0154 0.9998 3068457 PK04_096027 OCc1ccc(cc1)[C@H]2[C@H](C(=O)NCc3ccccc3)c4ccccc4C(=O)N2Cc5cc(cc(c5)C(F)(F)F)C(F)(F)F 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 B06 compound treatment 480260.0 103000.0 0.51 505760.0 153000.0 0.72 0.872 0.9865 3068854 PK04_096028 C[n+]1ccc2ccc(O)cc2c1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 B07 compound treatment 512160.0 135000.0 0.67 522950.0 170000.0 0.8 1.0418 0.9963 3187352 PK04_096029 Cc1ccc(nc1)N2[C@@H](c3ccc(CO)cc3)[C@@](C)(C(=O)NCCN4CCOCC4)c5ccccc5C2=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 B08 compound treatment 524830.0 148000.0 0.74 473920.0 121000.0 0.57 0.9235 0.9919 3187112 PK04_096030 COc1cc2CC[N+](=Cc2cc1O)Cc3cc4OCOc4cc3Br 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 B09 compound treatment 308550.0 -68800.0 -0.34 471640.0 119000.0 0.56 0.1521 0.2319 3068505 PK04_096031 CC(C)NC(=O)[C@H]1[C@@H](N(Cc2ccc(OC(F)(F)F)cc2)C(=O)c3ccccc13)c4ccc(CO)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 B10 compound treatment 460650.0 83300.0 0.42 482570.0 130000.0 0.61 0.7256 0.9826 3068855 PK04_096032 C[n+]1ccc(CCCO)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 B11 compound treatment 241440.0 -136000.0 -0.68 393130.0 40200.0 0.19 -0.3461 -0.4912 3068374 PK04_096033 Cc1ccc(S[C@@]2(CC(=O)N(Cc3ccccc3Cl)[C@@H]2c4ccc(CO)cc4)C(=O)NCc5ccccc5)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 B12 compound treatment 205460.0 -172000.0 -0.86 189280.0 -164000.0 -0.77 -1.1511 -0.9985 3187113 PK04_096034 COc1cc2CCN(Cc3cc4OCOc4cc3Br)C(C=C)c2cc1O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 B13 mock treatment 495920.0 119000.0 0.59 529000.0 176000.0 0.83 1.0046 0.9865 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 B14 mock treatment 475680.0 98400.0 0.49 527600.0 175000.0 0.82 0.9284 0.9698 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 B15 compound treatment 363130.0 -14200.0 -0.07 512000.0 159000.0 0.75 0.4791 0.6373 3187255 PK04_096035 COCCCNC(=O)[C@H]1[C@@H](N(C(=O)c2ccccc12)c3ccc(C)cn3)c4ccc(CO)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 B16 compound treatment 362560.0 -14800.0 -0.07 348000.0 -4900.0 -0.02 -0.0684 -0.8859 3068856 PK04_096036 Oc1ccc2cc[n+](Cc3sc4ccccc4c3Cl)cc2c1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 B17 compound treatment 517240.0 140000.0 0.7 494980.0 142000.0 0.67 0.9667 0.9998 3068608 PK04_096037 CC(C)NC(=O)[C@]1(C)[C@@H](N(Cc2ccc(OC(F)(F)F)cc2)C(=O)c3ccccc31)c4ccc(CO)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 B18 compound treatment 146020.0 -231000.0 -1.16 176420.0 -176000.0 -0.83 -1.4038 -0.9869 3187114 PK04_096038 COc1cc2CCN(Cc3cc4OCOc4cc3Br)C(C5CC5)c2cc1O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 B19 compound treatment 323530.0 -53800.0 -0.27 412820.0 59900.0 0.28 0.0093 0.024 3187171 PK04_096039 COc1ccccc1CN2[C@H]([C@H](C(=O)NCC(C)C)c3ccccc3C2=O)c4ccc(CO)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 B20 compound treatment 290240.0 -87100.0 -0.43 208650.0 -144000.0 -0.68 -0.7873 -0.9769 3068857 PK04_096040 OCCCc1cc[n+](Cc2ccc(o2)[N+](=O)[O-])cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 B21 compound treatment 406460.0 29100.0 0.15 448880.0 96000.0 0.45 0.4222 0.89 3068424 PK04_096041 CC(C)CNC(=O)[C@H]1[C@@H](N(Cc2cc(cc(c2)C(F)(F)F)C(F)(F)F)C(=O)c3ccccc13)c4ccc(CO)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 B22 compound treatment 278470.0 -98800.0 -0.49 367470.0 14600.0 0.07 -0.3006 -0.6032 3187115 PK04_096042 COc1cc2CCN(Cc3cc4OCOc4cc3Br)C(C)c2cc1O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 B23 compound treatment 509130.0 132000.0 0.66 480590.0 128000.0 0.6 0.8902 0.999 3187072 PK04_096043 CCCNC(=O)[C@H]1[C@@H](N(Cc2cc(cc(c2)C(F)(F)F)C(F)(F)F)C(=O)c3ccccc13)c4ccc(CO)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 B24 compound treatment 475170.0 97900.0 0.49 425130.0 72200.0 0.34 0.5858 0.9842 3187116 PK04_096044 COC(=O)C1=CN(C)C(C=C(C=C1C(=O)OC)c2ccc(CO)cc2)c3cccs3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 C01 compound treatment 482620.0 105000.0 0.53 435470.0 82600.0 0.39 0.6465 0.9889 3068218 PK04_096045 CC(C)N1C(=O)[C@]2(Cc3ccccc13)[C@@H](N(Cc4ccccc4Cl)C(=O)c5ccccc52)c6ccc(CO)cc6 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 C02 compound treatment 383710.0 6390.0 0.03 283770.0 -69100.0 -0.33 -0.2073 -0.6346 3186566 PK04_096046 CC(C)N1C(=O)[C@]2(Cc3ccccc13)[C@@H](N(C4CCCCC4)C(=O)c5ccccc52)c6ccc(CO)cc6 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 C03 compound treatment 147200.0 -230000.0 -1.15 165480.0 -187000.0 -0.88 -1.436 -0.9914 3186549 PK04_096047 OCc1ccc(cc1)[C@@H]2N(Cc3ccccc3Cl)C(=O)c4ccccc4[C@]2(Cc5ccccc5I)C(=O)NCC(F)(F)F 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 C04 compound treatment 204320.0 -173000.0 -0.86 209390.0 -144000.0 -0.68 -1.0883 -0.9925 3186726 PK04_096048 Cc1ccc(S[C@@]2(CC(=O)N(Cc3ccccc3Cl)[C@@H]2c4ccc(CO)cc4I)C(=O)NCc5ccccc5)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 C05 compound treatment 205280.0 -172000.0 -0.86 208080.0 -145000.0 -0.68 -1.0892 -0.9934 3186792 PK04_096049 Cc1ccc(S[C@@]2(CC(=O)N(Cc3ccccc3C(F)(F)F)[C@@H]2c4ccc(CO)cc4I)C(=O)NCCN5CCOCC5)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 C06 compound treatment 200020.0 -177000.0 -0.89 452750.0 99900.0 0.47 -0.294 -0.2934 3186987 PK04_096050 COCCCNC(=O)[C@]1(CC(=O)N(Cc2ccccc2)[C@@H]1c3ccc(CO)cc3)Sc4ccc(C)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 C07 compound treatment 198020.0 -179000.0 -0.9 180130.0 -173000.0 -0.81 -1.2078 -0.9988 3068275 PK04_096051 CC(C)CNC(=O)[C@]1(CC(=O)N(Cc2ccccc2Cl)[C@@H]1c3ccc(CO)cc3I)Sc4ccc(C)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 C08 compound treatment 426260.0 48900.0 0.24 307520.0 -45400.0 -0.21 0.0219 0.0675 3186560 PK04_096052 CC(C)NC(=O)[C@]1(Cc2ccccc2I)[C@@H](N(Cc3ccccc3)C(=O)c4ccccc41)c5ccc(CO)cc5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 C09 compound treatment 139880.0 -237000.0 -1.19 132130.0 -221000.0 -1.04 -1.5728 -0.9978 3068147 PK04_096053 COc1ccc(CCNC(=O)[C@]2(Cc3ccccc3I)[C@@H](N(Cc4ccccc4Cl)C(=O)c5ccccc52)c6ccc(CO)cc6)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 C10 compound treatment 242830.0 -134000.0 -0.67 299910.0 -53000.0 -0.25 -0.6512 -0.9089 3186976 PK04_096054 CC(C)CNC(=O)[C@]1(CC(=O)N(Cc2cc(cc(c2)C(F)(F)F)C(F)(F)F)[C@@H]1c3ccc(CO)cc3)Sc4ccc(C)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 C11 mock treatment 149150.0 -228000.0 -1.14 179000.0 -174000.0 -0.82 -1.3842 -0.9868 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 C12 mock treatment 305190.0 -72100.0 -0.36 267790.0 -85100.0 -0.4 -0.5378 -0.9986 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 C13 compound treatment 193800.0 -184000.0 -0.92 362750.0 9850.0 0.05 -0.6154 -0.6705 3186974 PK04_096055 COc1ccc(CCNC(=O)[C@]2(CC(=O)N(Cc3ccccc3C(F)(F)F)[C@@H]2c4ccc(CO)cc4)Sc5ccc(C)cc5)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 C14 compound treatment 180960.0 -196000.0 -0.98 392500.0 39600.0 0.19 -0.5618 -0.5627 3186876 PK04_096056 CC(C)N1[C@H](c2ccc(CO)cc2)[C@@](CC1=O)(Sc3ccc(C)cc3)C(=O)NCCCN(C)C 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 C15 mock treatment 294640.0 -82700.0 -0.41 262020.0 -90900.0 -0.43 -0.5942 -0.9999 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 C16 mock treatment 422360.0 45000.0 0.22 302600.0 -50300.0 -0.24 -0.0082 -0.0252 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 C17 compound treatment 201190.0 -176000.0 -0.88 310570.0 -42300.0 -0.2 -0.7628 -0.8458 3186553 PK04_096057 COc1ccc(CCNC(=O)[C@]2(Cc3ccccc3I)[C@@H](N(Cc4ccccc4C(F)(F)F)C(=O)c5ccccc52)c6ccc(CO)cc6)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 C18 compound treatment 382880.0 5560.0 0.03 405810.0 52900.0 0.25 0.1956 0.7812 3186634 PK04_096058 CC(C)N1C(=O)[C@]2(Cc3ccccc13)[C@@H](N(Cc4ccccc4C(F)(F)F)C(=O)c5ccccc52)c6ccc(CO)cc6 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 C19 compound treatment 278320.0 -99000.0 -0.49 315360.0 -37500.0 -0.18 -0.4745 -0.9037 3186638 PK04_096059 COc1ccc(CCN2C(=O)[C@]3(Cc4ccccc24)[C@@H](N(Cc5ccccc5)C(=O)c6ccccc63)c7ccc(CO)cc7)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 C20 compound treatment 213710.0 -164000.0 -0.82 435120.0 82200.0 0.39 -0.3043 -0.3366 3068219 PK04_096060 OCc1ccc(cc1)[C@@H]2N(Cc3ccccc3Cl)C(=O)c4ccccc4[C@]52Cc6ccccc6N(CC(F)(F)F)C5=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 C21 compound treatment 232660.0 -145000.0 -0.72 212900.0 -140000.0 -0.66 -0.9765 -0.9989 3068151 PK04_096061 CC(C)NC(=O)[C@]1(Cc2ccccc2I)[C@@H](N(Cc3ccccc3C(F)(F)F)C(=O)c4ccccc41)c5ccc(CO)cc5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 C22 compound treatment 360860.0 -16500.0 -0.08 279860.0 -73000.0 -0.34 -0.301 -0.8522 3068158 PK04_096062 OCc1ccc(cc1)[C@@H]2N(C3CCCCC3)C(=O)c4ccccc4[C@]52Cc6ccccc6N(CC(F)(F)F)C5=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 C23 compound treatment 192320.0 -185000.0 -0.92 212380.0 -141000.0 -0.66 -1.1207 -0.9865 3186800 PK04_096063 COCCCNC(=O)[C@]1(CC(=O)N(Cc2cc(cc(c2)C(F)(F)F)C(F)(F)F)[C@@H]1c3ccc(CO)cc3I)Sc4ccc(C)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 C24 compound treatment 409610.0 32300.0 0.16 336030.0 -16900.0 -0.08 0.0579 0.3223 3068376 PK04_096064 CN(C)CCCNC(=O)[C@]1(CC(=O)N(Cc2ccccc2Cl)[C@@H]1c3ccc(CO)cc3)Sc4ccc(C)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 D01 compound treatment 478560.0 101000.0 0.51 480290.0 127000.0 0.6 0.7813 0.9964 3068407 PK04_096065 Cc1ccc(S[C@@]2(CC(=O)N(Cc3cc(cc(c3)C(F)(F)F)C(F)(F)F)[C@@H]2c4ccc(CO)cc4)C(=O)NC5CC5)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 D02 compound treatment 307300.0 -70000.0 -0.35 264610.0 -88300.0 -0.42 -0.5409 -0.9963 3187117 PK04_096066 CN1C(=O)C2C(C3C(N(Cc4cccc(OC(F)(F)F)c4)C2C=C3CCCO)c5ccc(CN6CCCC6)cc5)C1=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 D03 compound treatment 205380.0 -172000.0 -0.86 184280.0 -169000.0 -0.79 -1.168 -0.9992 3187274 PK04_096067 OCc1ccc(cc1)[C@H]2[C@H](C(=O)NC3CC3)c4ccccc4C(=O)N2CC5(CC6CC7CC(C6)C5)C7 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 D04 compound treatment 394270.0 17000.0 0.08 388050.0 35200.0 0.17 0.1768 0.9517 3068858 PK04_096068 COc1cc2CCN(Cc3cccc(OC(F)(F)F)c3)C(C=C)c2cc1O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 D05 compound treatment 400250.0 22900.0 0.11 332960.0 -19900.0 -0.09 0.0147 0.0991 3187075 PK04_096069 CN(C)CCCNC(=O)[C@H]1[C@@H](N(Cc2cc(cc(c2)C(F)(F)F)C(F)(F)F)C(=O)c3ccccc13)c4ccc(CO)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 D06 compound treatment 508050.0 131000.0 0.65 440030.0 87100.0 0.41 0.7515 0.9748 3187118 PK04_096070 OCCCC1=CC(N(Cc2cc3OCOc3cc2Br)/C(=N\P(=O)(Oc4ccccc4)Oc5ccccc5)/C1)c6ccc(CN7CCCC7)cc6 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 D07 compound treatment 190400.0 -187000.0 -0.93 275040.0 -77900.0 -0.37 -0.9191 -0.9165 3068634 PK04_096071 CC(C)CNC(=O)[C@]1(C)[C@@H](N(Cc2cc(F)cc(c2)C(F)(F)F)C(=O)c3ccccc31)c4ccc(CO)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 D08 compound treatment 263720.0 -114000.0 -0.57 449340.0 96400.0 0.45 -0.0804 -0.1107 3068859 PK04_096072 OCc1ccc(cc1)c2cc[n+](Cc3ccc(o3)[N+](=O)[O-])cc2 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 D09 compound treatment 141950.0 -235000.0 -1.18 130960.0 -222000.0 -1.04 -1.5694 -0.9982 3067975 PK04_096073 CC(C)NC(=O)[C@]1(CC(=O)N(CC2(CC3CC4CC(C3)C2)C4)[C@@H]1c5ccc(CO)cc5)c6ccc(cc6)[N+](=O)[O-] 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 D10 compound treatment 456860.0 79500.0 0.4 509670.0 157000.0 0.74 0.8023 0.9579 3068860 PK04_096074 COc1cc2CCN(Cc3ccc(o3)[N+](=O)[O-])C(C)c2cc1O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 D11 mock treatment 303790.0 -73500.0 -0.37 307560.0 -45300.0 -0.21 -0.4105 -0.9666 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 D12 mock treatment 500540.0 123000.0 0.62 478500.0 126000.0 0.59 0.8529 0.9998 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 D13 compound treatment 243740.0 -134000.0 -0.67 270080.0 -82800.0 -0.39 -0.7472 -0.9672 3187429 PK04_096075 C[C@]1([C@@H](N(Cc2cc(cc(c2)C(F)(F)F)C(F)(F)F)C(=O)c3ccccc31)c4ccc(CO)cc4)C(=O)NCCN5CCOCC5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 D14 compound treatment 221790.0 -156000.0 -0.78 472680.0 120000.0 0.56 -0.1509 -0.1572 3187119 PK04_096076 CN1C(=O)C2C(C3C(C4CC4)N(Cc5cccc(OC(F)(F)F)c5)C2C=C3CCCO)C1=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 D15 mock treatment 415050.0 37700.0 0.19 282910.0 -70000.0 -0.33 -0.0995 -0.2624 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 D16 mock treatment 445400.0 68100.0 0.34 489850.0 137000.0 0.64 0.6959 0.9554 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 D17 compound treatment 427710.0 50400.0 0.25 445280.0 92400.0 0.43 0.4852 0.9663 3187348 PK04_096077 CC(C)NC(=O)[C@]1(C)[C@@H](N(C(C)C)C(=O)c2ccccc21)c3ccc(CO)cc3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 D18 compound treatment 352040.0 -25300.0 -0.13 341290.0 -11600.0 -0.05 -0.1279 -0.9297 3068861 PK04_096078 COc1cc2CCN(Cc3ccc(o3)[N+](=O)[O-])C(C4CC4)c2cc1O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 D19 compound treatment 386670.0 9350.0 0.05 450720.0 97800.0 0.46 0.3584 0.7749 3187354 PK04_096079 CC(C)NC(=O)[C@]1(C)[C@@H](N(C(=O)c2ccccc21)c3ccc(C)cn3)c4ccc(CO)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 D20 compound treatment 303810.0 -73500.0 -0.37 331000.0 -21900.0 -0.1 -0.3324 -0.8718 3187120 PK04_096080 OCc1ccc(cc1)c2cc[n+](Cc3sc4ccccc4c3Cl)cc2 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 D21 compound treatment 221280.0 -156000.0 -0.78 377080.0 24200.0 0.11 -0.4706 -0.5976 3187433 PK04_096081 CCCNC(=O)[C@]1(C)[C@@H](N(Cc2ccccc2)C(=O)c3ccccc31)c4ccc(CO)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 D22 compound treatment 437820.0 60500.0 0.3 448850.0 96000.0 0.45 0.5328 0.981 3068862 PK04_096082 COc1cc2CCN(C)C(C)c2cc1O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 D23 compound treatment 375270.0 -2050.0 -0.01 416030.0 63100.0 0.3 0.2027 0.6824 3068462 PK04_096083 OCc1ccc(cc1)[C@H]2[C@H](C(=O)NC3CC3)c4ccccc4C(=O)N2Cc5ccccc5C(F)(F)F 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 D24 compound treatment 199330.0 -178000.0 -0.89 332130.0 -20800.0 -0.1 -0.6977 -0.7801 3187121 PK04_096084 COC(=O)C1=CN(Cc2sc3ccccc3c2Cl)C(C=C(C=C1C(=O)OC)c4ccc(CO)cc4)C5CC5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 E01 mock treatment 294960.0 -82400.0 -0.41 499880.0 147000.0 0.69 0.198 0.2461 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 E02 mock treatment 502910.0 126000.0 0.63 436830.0 83900.0 0.39 0.7227 0.9751 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 E03 compound treatment 189670.0 -188000.0 -0.94 149120.0 -204000.0 -0.96 -1.3405 -0.9999 3186708 PK04_096085 Cc1ccc(S[C@@]2(CC(=O)N([C@@H]2c3ccc(CO)cc3I)C4CCCCC4)C(=O)NCCN5CCOCC5)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 E04 compound treatment 219950.0 -157000.0 -0.79 223170.0 -130000.0 -0.61 -0.9872 -0.9922 3186710 PK04_096086 CC(C)NC(=O)[C@]1(CC(=O)N([C@@H]1c2ccc(CO)cc2I)C3CCCCC3)Sc4ccc(C)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 E05 compound treatment 543800.0 166000.0 0.83 245640.0 -107000.0 -0.5 0.2312 0.2377 3186888 PK04_096087 Cc1ccc(S[C@@]2(CC(=O)N(Cc3ccccc3Cl)[C@@H]2c4ccc(CO)cc4)C(=O)NCC(F)(F)F)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 E06 compound treatment 315380.0 -61900.0 -0.31 359860.0 6960.0 0.03 -0.1956 -0.6288 3186565 PK04_096088 OCc1ccc(cc1)[C@@H]2N(C3CCCCC3)C(=O)c4ccccc4[C@]52Cc6ccccc6N(Cc7ccccc7)C5=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 E07 compound treatment 351140.0 -26200.0 -0.13 466890.0 114000.0 0.54 0.2867 0.5195 3186983 PK04_096089 Cc1ccc(S[C@@]2(CC(=O)N(Cc3ccccc3)[C@@H]2c4ccc(CO)cc4)C(=O)NCCN5CCOCC5)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 E08 compound treatment 460870.0 83600.0 0.42 550900.0 198000.0 0.93 0.9536 0.9344 3067581 PK04_096090 CCCN1C(=O)[C@]2(CC(=O)N([C@@H]2c3ccc(CO)cc13)C4CCCCC4)c5ccc(cc5)[N+](=O)[O-] 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 E09 mock treatment 221300.0 -156000.0 -0.78 530950.0 178000.0 0.84 0.0412 0.036 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 E10 mock treatment 330020.0 -47300.0 -0.24 568770.0 216000.0 1.02 0.5509 0.5285 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 E11 compound treatment 204730.0 -173000.0 -0.86 231860.0 -121000.0 -0.57 -1.0121 -0.9797 3186717 PK04_096091 CC(C)CNC(=O)[C@]1(CC(=O)N(C2Cc3ccccc3C2)[C@@H]1c4ccc(CO)cc4I)Sc5ccc(C)cc5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 E12 compound treatment 500090.0 123000.0 0.61 453070.0 100000.0 0.47 0.7668 0.9915 3068221 PK04_096092 CN(C)CCCN1C(=O)[C@]2(Cc3ccccc13)[C@@H](N(Cc4ccccc4Cl)C(=O)c5ccccc52)c6ccc(CO)cc6 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 E13 compound treatment 199700.0 -178000.0 -0.89 221120.0 -132000.0 -0.62 -1.0656 -0.9846 3068273 PK04_096093 CN(C)CCCNC(=O)[C@]1(CC(=O)N(C2Cc3ccccc3C2)[C@@H]1c4ccc(CO)cc4I)Sc5ccc(C)cc5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 E14 compound treatment 410640.0 33300.0 0.17 404720.0 51800.0 0.24 0.29 0.9827 3068377 PK04_096094 CCCNC(=O)[C@]1(CC(=O)N(Cc2ccccc2C(F)(F)F)[C@@H]1c3ccc(CO)cc3)Sc4ccc(C)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 E15 compound treatment 329410.0 -47900.0 -0.24 540760.0 188000.0 0.88 0.4556 0.4977 3068408 PK04_096095 Cc1ccc(S[C@@]2(CC(=O)N(Cc3cc(cc(c3)C(F)(F)F)C(F)(F)F)[C@@H]2c4ccc(CO)cc4)C(=O)NCc5ccccc5)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 E16 compound treatment 191320.0 -186000.0 -0.93 265640.0 -87300.0 -0.41 -0.9471 -0.9326 3186635 PK04_096096 CN(C)CCCN1C(=O)[C@]2(Cc3ccccc13)[C@@H](N(Cc4ccccc4C(F)(F)F)C(=O)c5ccccc52)c6ccc(CO)cc6 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 E17 mock treatment 297180.0 -80100.0 -0.4 508670.0 156000.0 0.73 0.2351 0.2816 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 E18 mock treatment 503040.0 126000.0 0.63 355630.0 2730.0 0.01 0.4531 0.7214 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 E19 compound treatment 205760.0 -172000.0 -0.86 213630.0 -139000.0 -0.66 -1.0691 -0.9912 3186791 PK04_096097 CC(C)CNC(=O)[C@]1(CC(=O)N(Cc2ccccc2C(F)(F)F)[C@@H]1c3ccc(CO)cc3I)Sc4ccc(C)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 E20 compound treatment 439220.0 61900.0 0.31 456690.0 104000.0 0.49 0.5638 0.9757 3068233 PK04_096098 CC(C)N1C(=O)[C@]2(Cc3ccccc13)[C@@H](N(Cc4ccccc4)C(=O)c5ccccc52)c6ccc(CO)cc6 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 E21 compound treatment 218640.0 -159000.0 -0.79 211490.0 -141000.0 -0.67 -1.0307 -0.9962 3186719 PK04_096099 COc1ccc(CCNC(=O)[C@]2(CC(=O)N(C3Cc4ccccc4C3)[C@@H]2c5ccc(CO)cc5I)Sc6ccc(C)cc6)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 E22 compound treatment 184720.0 -193000.0 -0.96 182250.0 -171000.0 -0.8 -1.2478 -0.996 3186789 PK04_096100 CN(C)CCCNC(=O)[C@]1(CC(=O)N(Cc2ccccc2Cl)[C@@H]1c3ccc(CO)cc3I)Sc4ccc(C)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 E23 compound treatment 203090.0 -174000.0 -0.87 195490.0 -157000.0 -0.74 -1.1388 -0.9968 3186803 PK04_096101 COc1ccc(CCNC(=O)[C@]2(CC(=O)N(Cc3ccccc3)[C@@H]2c4ccc(CO)cc4I)Sc5ccc(C)cc5)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 E24 compound treatment 192640.0 -185000.0 -0.92 119840.0 -233000.0 -1.1 -1.4274 -0.9963 3186711 PK04_096102 CN(C)CCCNC(=O)[C@]1(CC(=O)N([C@@H]1c2ccc(CO)cc2I)C3CCCCC3)Sc4ccc(C)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 F01 mock treatment 232880.0 -144000.0 -0.72 417640.0 64700.0 0.3 -0.2948 -0.3765 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 F02 mock treatment 511950.0 135000.0 0.67 359390.0 6490.0 0.03 0.4971 0.7384 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 F03 compound treatment 292510.0 -84800.0 -0.42 264590.0 -88300.0 -0.42 -0.5932 -1.0 3068521 PK04_096103 CCCNC(=O)[C@H]1[C@@H](N(C2Cc3ccccc3C2)C(=O)c4ccccc14)c5ccc(CO)cc5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 F04 compound treatment 504330.0 127000.0 0.63 242320.0 -111000.0 -0.52 0.0808 0.0985 3187122 PK04_096104 COC(=O)C1=CN(Cc2cc3OCOc3cc2Br)C(C=C(CCCO)C=C1C(=O)OC)c4ccc(CN5CCCC5)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 F05 compound treatment 170080.0 -207000.0 -1.04 164740.0 -188000.0 -0.89 -1.3577 -0.997 3068461 PK04_096105 CCCNC(=O)[C@H]1[C@@H](N(Cc2ccccc2C(F)(F)F)C(=O)c3ccccc13)c4ccc(CO)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 F06 compound treatment 158090.0 -219000.0 -1.09 191200.0 -162000.0 -0.76 -1.312 -0.9842 3068863 PK04_096106 COc1cc2CCN(Cc3sc4ccccc4c3Cl)C(c5ccc(CN6CCCC6)cc5)c2cc1O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 F07 compound treatment 327460.0 -49900.0 -0.25 518270.0 165000.0 0.78 0.3739 0.4579 3187077 PK04_096107 CC(C)CNC(=O)[C@H]1[C@@H](N(Cc2ccccc2C(F)(F)F)C(=O)c3ccccc13)c4ccc(CO)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 F08 compound treatment 297820.0 -79500.0 -0.4 242040.0 -111000.0 -0.52 -0.6495 -0.991 3187123 PK04_096108 CN/1C(C=C(CCCO)C\C1=N\P(=O)(Oc2ccccc2)Oc3ccccc3)c4ccc(CN5CCCC5)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 F09 mock treatment 351730.0 -25600.0 -0.13 521760.0 169000.0 0.79 0.4713 0.5858 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 F10 mock treatment 563640.0 186000.0 0.93 233730.0 -119000.0 -0.56 0.2617 0.2409 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 F11 compound treatment 189040.0 -188000.0 -0.94 190990.0 -162000.0 -0.76 -1.2034 -0.9945 3187438 PK04_096109 CN(C)CCCNC(=O)[C@]1(C)[C@@H](N(Cc2ccccc2)C(=O)c3ccccc31)c4ccc(CO)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 F12 compound treatment 195320.0 -182000.0 -0.91 248840.0 -104000.0 -0.49 -0.9888 -0.9578 3187124 PK04_096110 COC(=O)C1=CN(Cc2cccc(OC(F)(F)F)c2)C(C=C(C=C1C(=O)OC)c3ccc(CO)cc3)c4cccs4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 F13 compound treatment 236090.0 -141000.0 -0.71 531620.0 179000.0 0.84 0.0957 0.0872 3068559 PK04_096111 OCc1ccc(cc1)[C@H]2[C@H](C(=O)NCC(F)(F)F)c3ccccc3C(=O)N2C4CCCCC4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 F14 compound treatment 262250.0 -115000.0 -0.57 239060.0 -114000.0 -0.54 -0.785 -0.9994 3068864 PK04_096112 COC(=O)C1=CN(C)C(C=C(CCCO)C=C1C(=O)OC)c2cccs2 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 F15 compound treatment 179160.0 -198000.0 -0.99 198680.0 -154000.0 -0.73 -1.2128 -0.9883 3186801 PK04_096113 CC(C)CNC(=O)[C@]1(CC(=O)N(Cc2ccccc2)[C@@H]1c3ccc(CO)cc3I)Sc4ccc(C)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 F16 compound treatment 186580.0 -191000.0 -0.95 323600.0 -29300.0 -0.14 -0.7711 -0.8011 3187125 PK04_096114 COC(=O)C1=CN(Cc2sc3ccccc3c2Cl)C(C=C(CCCO)C=C1C(=O)OC)C4CC4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 F17 mock treatment 524640.0 147000.0 0.74 386520.0 33600.0 0.16 0.6321 0.8399 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 F18 mock treatment 424730.0 47400.0 0.24 446830.0 93900.0 0.44 0.4799 0.9573 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 F19 compound treatment 196030.0 -181000.0 -0.91 184370.0 -169000.0 -0.79 -1.2008 -0.9978 3186718 PK04_096115 Cc1ccc(S[C@@]2(CC(=O)N(C3Cc4ccccc4C3)[C@@H]2c5ccc(CO)cc5I)C(=O)NC6CC6)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 F20 compound treatment 257630.0 -120000.0 -0.6 302880.0 -50000.0 -0.24 -0.5891 -0.9169 3068865 PK04_096116 COC(=O)C1=CN(Cc2cc3OCOc3cc2Br)C(C=C(CCCO)C=C1C(=O)OC)c4cccs4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 F21 compound treatment 271870.0 -105000.0 -0.53 213820.0 -139000.0 -0.65 -0.835 -0.9942 3067569 PK04_096117 CC(C)NC(=O)[C@]1(CC(=O)N([C@@H]1c2ccc(CO)cc2I)C3CCCCC3)c4ccc(cc4)[N+](=O)[O-] 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 F22 compound treatment 305090.0 -72200.0 -0.36 421380.0 68500.0 0.32 -0.0273 -0.0565 3187126 PK04_096118 COc1cc2CCN(Cc3ccc(o3)[N+](=O)[O-])C(C=C)c2cc1O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 F23 compound treatment 369140.0 -8180.0 -0.04 306320.0 -46600.0 -0.22 -0.1838 -0.8247 3068643 PK04_096119 COCCCNC(=O)[C@]1(C)[C@@H](N(Cc2cc(F)cc(c2)C(F)(F)F)C(=O)c3ccccc31)c4ccc(CO)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 F24 compound treatment 283310.0 -94000.0 -0.47 436020.0 83100.0 0.39 -0.0555 -0.0909 3187127 PK04_096120 CN/1C(C=C(C\C1=N\P(=O)(Oc2ccccc2)Oc3ccccc3)c4ccc(CO)cc4)c5cccs5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 G01 compound treatment 476020.0 98700.0 0.49 203360.0 -150000.0 -0.7 -0.1488 -0.1732 3186434 PK04_096121 CN(C)CCCN1C(=O)[C@]2(CC(=O)N([C@@H]2c3ccc(CO)cc13)C4CCCCC4)c5ccc(cc5)[N+](=O)[O-] 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 G02 compound treatment 463800.0 86500.0 0.43 327750.0 -25100.0 -0.12 0.2218 0.4952 3067602 PK04_096122 CC(C)N1C(=O)[C@]2(CC(=O)N([C@@H]2c3ccc(CO)cc13)C4CCCCC4)c5ccc(cc5)[N+](=O)[O-] 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 G03 mock treatment 485120.0 108000.0 0.54 507140.0 154000.0 0.73 0.8937 0.9892 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 G04 mock treatment 475120.0 97800.0 0.49 553540.0 201000.0 0.94 1.0127 0.953 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 G05 compound treatment 146400.0 -231000.0 -1.15 154320.0 -199000.0 -0.93 -1.476 -0.9945 3068238 PK04_096123 COc1ccc(CCNC(=O)[C@]2(CC(=O)N([C@@H]2c3ccc(CO)cc3I)C4CCCCC4)Sc5ccc(C)cc5)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 G06 compound treatment 217400.0 -160000.0 -0.8 227470.0 -125000.0 -0.59 -0.9819 -0.9889 3068315 PK04_096124 Cc1ccc(S[C@@]2(CC(=O)N(Cc3cc(cc(c3)C(F)(F)F)C(F)(F)F)[C@@H]2c4ccc(CO)cc4I)C(=O)NC5CC5)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 G07 compound treatment 219360.0 -158000.0 -0.79 132090.0 -221000.0 -1.04 -1.2923 -0.9908 3186805 PK04_096125 Cc1ccc(S[C@@]2(CC(=O)N(Cc3ccccc3)[C@@H]2c4ccc(CO)cc4I)C(=O)NCC(F)(F)F)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 G08 compound treatment 214820.0 -162000.0 -0.81 244210.0 -109000.0 -0.51 -0.9354 -0.9752 3186712 PK04_096126 COCCCNC(=O)[C@]1(CC(=O)N([C@@H]1c2ccc(CO)cc2I)C3CCCCC3)Sc4ccc(C)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 G09 compound treatment 181150.0 -196000.0 -0.98 212020.0 -141000.0 -0.66 -1.1614 -0.9819 3068360 PK04_096127 CC(C)N1[C@H](c2ccc(CO)cc2)[C@@](CC1=O)(Sc3ccc(C)cc3)C(=O)NCCN4CCOCC4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 G10 compound treatment 164960.0 -212000.0 -1.06 468160.0 115000.0 0.54 -0.3666 -0.3078 3186431 PK04_096128 COc1ccc(CCN2C(=O)[C@]3(CC(=O)N([C@@H]3c4ccc(CO)cc24)C5CCCCC5)c6ccc(cc6)[N+](=O)[O-])cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 G11 compound treatment 124120.0 -253000.0 -1.26 214030.0 -139000.0 -0.65 -1.3561 -0.9528 3186642 PK04_096129 CCCNC(=O)[C@]1(CC(=O)N([C@@H]1c2ccc(CO)cc2I)C3CCCCC3)Sc4ccc(C)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 G12 compound treatment 160340.0 -217000.0 -1.08 321340.0 -31600.0 -0.15 -0.8713 -0.7965 3068326 PK04_096130 CCCNC(=O)[C@]1(CC(=O)N([C@@H]1c2ccc(CO)cc2)C3CCCCC3)Sc4ccc(C)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 G13 compound treatment 207770.0 -170000.0 -0.85 186760.0 -166000.0 -0.78 -1.1514 -0.9992 3186484 PK04_096131 CCCN1C(=O)[C@]2(CC(=O)N(CC3(CC4CC5CC(C4)C3)C5)[C@@H]2c6ccc(CO)cc16)c7ccc(cc7)[N+](=O)[O-] 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 G14 compound treatment 180650.0 -197000.0 -0.98 514570.0 162000.0 0.76 -0.1568 -0.1263 3068146 PK04_096132 CC(C)CNC(=O)[C@]1(Cc2ccccc2I)[C@@H](N(Cc3ccccc3Cl)C(=O)c4ccccc41)c5ccc(CO)cc5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 G15 compound treatment 209230.0 -168000.0 -0.84 301930.0 -51000.0 -0.24 -0.7631 -0.8741 3068195 PK04_096133 COc1ccccc1CN2[C@@H](c3ccc(CO)cc3)[C@]4(Cc5ccccc5N(C6CC6)C4=O)c7ccccc7C2=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 G16 compound treatment 194600.0 -183000.0 -0.91 216650.0 -136000.0 -0.64 -1.0985 -0.985 3068279 PK04_096134 CC(C)NC(=O)[C@]1(CC(=O)N(Cc2ccccc2Cl)[C@@H]1c3ccc(CO)cc3I)Sc4ccc(C)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 G17 compound treatment 314440.0 -62900.0 -0.31 259390.0 -93500.0 -0.44 -0.5331 -0.9864 3068328 PK04_096135 Cc1ccc(S[C@@]2(CC(=O)N([C@@H]2c3ccc(CO)cc3)C4CCCCC4)C(=O)NCCN5CCOCC5)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 G18 compound treatment 143580.0 -234000.0 -1.17 221860.0 -131000.0 -0.62 -1.2613 -0.9554 3068311 PK04_096136 CN(C)CCCNC(=O)[C@]1(CC(=O)N(Cc2ccccc2C(F)(F)F)[C@@H]1c3ccc(CO)cc3I)Sc4ccc(C)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 G19 mock treatment 347590.0 -29700.0 -0.15 452030.0 99100.0 0.47 0.2247 0.4592 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 G20 mock treatment 393030.0 15700.0 0.08 365840.0 12900.0 0.06 0.0985 0.9921 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 G21 compound treatment 172160.0 -205000.0 -1.02 220260.0 -133000.0 -0.62 -1.1657 -0.9717 3068284 PK04_096137 Cc1ccc(S[C@@]2(CC(=O)N(Cc3ccccc3C(F)(F)F)[C@@H]2c4ccc(CO)cc4I)C(=O)NCc5ccccc5)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 G22 compound treatment 272320.0 -105000.0 -0.52 304160.0 -48700.0 -0.23 -0.5329 -0.9311 3186501 PK04_096138 OCc1ccc(cc1)[C@@H]2N(Cc3ccccc3Cl)C(=O)c4ccccc4[C@]2(Cc5ccccc5I)C(=O)NCCN6CCOCC6 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 G23 compound treatment 190120.0 -187000.0 -0.93 294610.0 -58300.0 -0.27 -0.855 -0.8775 3186555 PK04_096139 OCc1ccc(cc1)[C@@H]2N(Cc3ccccc3C(F)(F)F)C(=O)c4ccccc4[C@]2(Cc5ccccc5I)C(=O)NCC(F)(F)F 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 G24 compound treatment 455000.0 77700.0 0.39 306210.0 -46700.0 -0.22 0.1191 0.2671 3186877 PK04_096140 CCCNC(=O)[C@]1(CC(=O)N(C2Cc3ccccc3C2)[C@@H]1c4ccc(CO)cc4)Sc5ccc(C)cc5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 H01 compound treatment 521920.0 145000.0 0.72 150450.0 -202000.0 -0.95 -0.1627 -0.1361 3186629 PK04_096141 OCc1ccc(cc1)[C@@H]2N(Cc3ccccc3Cl)C(=O)c4ccccc4[C@]52Cc6ccccc6N(CCN7CCOCC7)C5=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 H02 compound treatment 483330.0 106000.0 0.53 456320.0 103000.0 0.49 0.7184 0.9991 3068866 PK04_096142 OCc1ccc(cc1)c2cc[n+](Cc3cc4OCOc4cc3Br)cc2 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 H03 mock treatment 400440.0 23100.0 0.12 203540.0 -149000.0 -0.7 -0.4151 -0.583 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 H04 mock treatment 507220.0 130000.0 0.65 387360.0 34500.0 0.16 0.5734 0.8574 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 H05 compound treatment 216270.0 -161000.0 -0.8 221040.0 -132000.0 -0.62 -1.0073 -0.9918 3186432 PK04_096143 OCc1ccc2[C@H]3N(C4CCCCC4)C(=O)C[C@@]3(C(=O)N(Cc5ccccc5)c2c1)c6ccc(cc6)[N+](=O)[O-] 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 H06 compound treatment 207100.0 -170000.0 -0.85 472930.0 120000.0 0.56 -0.2019 -0.1979 3068867 PK04_096144 OCc1ccc(cc1)c2cc[n+](Cc3cccc(OC(F)(F)F)c3)cc2 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 H07 compound treatment 180560.0 -197000.0 -0.98 535750.0 183000.0 0.86 -0.0867 -0.0664 3187128 PK04_096145 CC(C)CN1C(=O)[C@]2(CC(=O)N(CC3C4CC5CC(C4)CC3C5)[C@@H]2c6ccc(CO)cc16)c7ccc(cc7)[N+](=O)[O-] 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 H08 compound treatment 368170.0 -9150.0 -0.05 368160.0 15300.0 0.07 0.0185 0.2169 3068868 PK04_096146 COc1cc2CC[N+](=Cc2cc1O)Cc3sc4ccccc4c3Cl 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 H09 compound treatment 172000.0 -205000.0 -1.03 338000.0 -14900.0 -0.07 -0.7747 -0.7537 3186637 PK04_096147 OCc1ccc(cc1)[C@@H]2N(Cc3ccccc3)C(=O)c4ccccc4[C@]52Cc6ccccc6N(C7CC7)C5=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 H10 compound treatment 278850.0 -98500.0 -0.49 212050.0 -141000.0 -0.66 -0.8162 -0.9892 3187129 PK04_096148 COc1cc2CCN(Cc3cccc(OC(F)(F)F)c3)C(C4CC4)c2cc1O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 H11 compound treatment 174250.0 -203000.0 -1.01 381980.0 29100.0 0.14 -0.6204 -0.6063 3187130 PK04_096149 CC1(C)OB(OC1(C)C)/C=C\CC(OC(=O)c2ccncc2)c3ccccc3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 H12 compound treatment 508180.0 131000.0 0.65 201990.0 -151000.0 -0.71 -0.0398 -0.0412 3187131 PK04_096150 C[n+]1ccc(cc1)c2ccc(CO)cc2 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 H13 compound treatment 297180.0 -80100.0 -0.4 192210.0 -161000.0 -0.76 -0.8175 -0.9558 3068898 PK04_096151 COC(=O)c1ccc(OC)c(/C=C\CC(OC(=O)C)c2ccccc2)c1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 H14 compound treatment 271650.0 -106000.0 -0.53 395360.0 42500.0 0.2 -0.232 -0.4111 3187132 PK04_096152 CN1C(=O)C2C(C3C(N(Cc4cc5OCOc5cc4Br)C2C=C3CCCO)c6cccs6)C1=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 H15 compound treatment 443780.0 66500.0 0.33 540670.0 188000.0 0.88 0.8592 0.9107 3187133 PK04_096153 COC(=O)c1ccc(OC)c(/C=C\CC(CCc2ccccc2)OC(=O)C)c1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 H16 compound treatment 328740.0 -48600.0 -0.24 242880.0 -110000.0 -0.52 -0.5375 -0.9404 3187134 PK04_096154 OCc1ccc(cc1)C2=CC(N(Cc3cccc(OC(F)(F)F)c3)/C(=N\P(=O)(Oc4ccccc4)Oc5ccccc5)/C2)c6cccs6 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 H17 compound treatment 514880.0 138000.0 0.69 222400.0 -130000.0 -0.61 0.0518 0.0562 3068899 PK04_096155 COC(=O)c1ccc(OC)c(/C=C\CC(CCc2ccccc2)OC(=O)c3ccncc3)c1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 H18 compound treatment 441410.0 64100.0 0.32 249920.0 -103000.0 -0.48 -0.1162 -0.2001 3068900 PK04_096156 COc1cc2CCN(Cc3sc4ccccc4c3Cl)C(C5CC5)c2cc1O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 H19 mock treatment 214920.0 -162000.0 -0.81 428640.0 75700.0 0.36 -0.3216 -0.363 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 H20 mock treatment 557070.0 180000.0 0.9 449700.0 96800.0 0.46 0.9568 0.9505 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 H21 compound treatment 155360.0 -222000.0 -1.11 137450.0 -215000.0 -1.01 -1.5005 -0.999 3187204 PK04_096157 CC(C)(C)OC(=O)COc1cccc(c1)C(=O)CCN2CCOCC2 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 H22 compound treatment 292530.0 -84800.0 -0.42 223120.0 -130000.0 -0.61 -0.7311 -0.984 3187205 PK04_096158 OCCCc1cc[n+](Cc2cc3OCOc3cc2Br)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 H23 compound treatment 380430.0 3110.0 0.02 378100.0 25200.0 0.12 0.0948 0.7931 3068901 PK04_096159 COc1ccc(/C=C/C(=O)c2cccc(OCC(=O)OC(C)(C)C)c2)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 H24 compound treatment 208840.0 -168000.0 -0.84 291680.0 -61200.0 -0.29 -0.7986 -0.898 3187206 PK04_096160 COC(=O)C1=CN(Cc2cc3OCOc3cc2Br)C(C=C(CCCO)C=C1C(=O)OC)C4CC4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 I01 compound treatment 210180.0 -167000.0 -0.83 239840.0 -113000.0 -0.53 -0.9663 -0.9763 3186796 PK04_096161 Cc1ccc(S[C@@]2(CC(=O)N(Cc3cc(cc(c3)C(F)(F)F)C(F)(F)F)[C@@H]2c4ccc(CO)cc4I)C(=O)NCCN5CCOCC5)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 I02 compound treatment 495620.0 118000.0 0.59 420710.0 67800.0 0.32 0.6433 0.9581 3186628 PK04_096162 CC(C)CN1C(=O)[C@]2(Cc3ccccc13)[C@@H](N(Cc4ccccc4Cl)C(=O)c5ccccc52)c6ccc(CO)cc6 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 I03 compound treatment 212060.0 -165000.0 -0.83 136640.0 -216000.0 -1.02 -1.3029 -0.9946 3186882 PK04_096163 CN(C)CCCNC(=O)[C@]1(CC(=O)N(C2Cc3ccccc3C2)[C@@H]1c4ccc(CO)cc4)Sc5ccc(C)cc5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 I04 compound treatment 170480.0 -207000.0 -1.03 210770.0 -142000.0 -0.67 -1.2032 -0.9778 3186797 PK04_096164 COc1ccc(CCNC(=O)[C@]2(CC(=O)N(Cc3cc(cc(c3)C(F)(F)F)C(F)(F)F)[C@@H]2c4ccc(CO)cc4I)Sc5ccc(C)cc5)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 I05 mock treatment 350350.0 -27000.0 -0.13 137890.0 -215000.0 -1.01 -0.8104 -0.7943 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 I06 mock treatment 496740.0 119000.0 0.6 192560.0 -160000.0 -0.75 -0.1115 -0.116 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 I07 compound treatment 519280.0 142000.0 0.71 198170.0 -155000.0 -0.73 -0.0133 -0.0131 3186430 PK04_096165 OCc1ccc2[C@H]3N(C4CCCCC4)C(=O)C[C@@]3(C(=O)N(C5CC5)c2c1)c6ccc(cc6)[N+](=O)[O-] 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 I08 compound treatment 464840.0 87500.0 0.44 218750.0 -134000.0 -0.63 -0.1371 -0.1786 3186557 PK04_096166 CC(C)CNC(=O)[C@]1(Cc2ccccc2I)[C@@H](N(Cc3ccccc3)C(=O)c4ccccc41)c5ccc(CO)cc5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 I09 compound treatment 209480.0 -168000.0 -0.84 196740.0 -156000.0 -0.73 -1.1121 -0.9978 3186558 PK04_096167 OCc1ccc(cc1)[C@@H]2N(Cc3ccccc3)C(=O)c4ccccc4[C@]2(Cc5ccccc5I)C(=O)NCCN6CCOCC6 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 I10 compound treatment 214830.0 -162000.0 -0.81 227370.0 -126000.0 -0.59 -0.9914 -0.9878 3068320 PK04_096168 CCCNC(=O)[C@]1(CC(=O)N(Cc2ccccc2)[C@@H]1c3ccc(CO)cc3I)Sc4ccc(C)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 I11 compound treatment 254240.0 -123000.0 -0.61 152920.0 -200000.0 -0.94 -1.0998 -0.9787 3068364 PK04_096169 COCCCNC(=O)[C@]1(CC(=O)N(C(C)C)[C@@H]1c2ccc(CO)cc2)Sc3ccc(C)cc3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 I12 compound treatment 184730.0 -193000.0 -0.96 196210.0 -157000.0 -0.74 -1.2013 -0.9914 3186489 PK04_096170 OCc1ccc(cc1)[C@@H]2N(C3CCCCC3)C(=O)c4ccccc4[C@]2(Cc5ccccc5I)C(=O)NCCN6CCOCC6 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 I13 compound treatment 246030.0 -131000.0 -0.66 512500.0 160000.0 0.75 0.0672 0.0674 3186807 PK04_096171 CC(C)CNC(=O)[C@]1(CC(=O)N([C@@H]1c2ccc(CO)cc2)C3CCCCC3)Sc4ccc(C)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 I14 compound treatment 222800.0 -155000.0 -0.77 232500.0 -120000.0 -0.57 -0.9461 -0.9884 3068281 PK04_096172 COCCCNC(=O)[C@]1(CC(=O)N(Cc2ccccc2Cl)[C@@H]1c3ccc(CO)cc3I)Sc4ccc(C)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 I15 compound treatment 440870.0 63600.0 0.32 428280.0 75400.0 0.35 0.4752 0.9985 3186567 PK04_096173 CN(C)CCCN1C(=O)[C@]2(Cc3ccccc13)[C@@H](N(C4CCCCC4)C(=O)c5ccccc52)c6ccc(CO)cc6 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 I16 compound treatment 207840.0 -169000.0 -0.85 449080.0 96200.0 0.45 -0.2786 -0.2903 3068410 PK04_096174 Cc1ccc(S[C@@]2(CC(=O)N(Cc3cc(cc(c3)C(F)(F)F)C(F)(F)F)[C@@H]2c4ccc(CO)cc4)C(=O)NCC(F)(F)F)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 I17 compound treatment 471800.0 94500.0 0.47 359460.0 6560.0 0.03 0.3555 0.7517 3186973 PK04_096175 Cc1ccc(S[C@@]2(CC(=O)N(Cc3ccccc3C(F)(F)F)[C@@H]2c4ccc(CO)cc4)C(=O)NC5CC5)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 I18 compound treatment 385840.0 8520.0 0.04 217250.0 -136000.0 -0.64 -0.4211 -0.6585 3068148 PK04_096176 CC(C)NC(=O)[C@]1(Cc2ccccc2I)[C@@H](N(Cc3ccccc3Cl)C(=O)c4ccccc41)c5ccc(CO)cc5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 I19 compound treatment 218750.0 -159000.0 -0.79 221930.0 -131000.0 -0.62 -0.9956 -0.9923 3068239 PK04_096177 Cc1ccc(S[C@@]2(CC(=O)N([C@@H]2c3ccc(CO)cc3I)C4CCCCC4)C(=O)NCC(F)(F)F)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 I20 compound treatment 247570.0 -130000.0 -0.65 195750.0 -157000.0 -0.74 -0.9809 -0.9978 3068268 PK04_096178 CCCNC(=O)[C@]1(CC(=O)N(C2Cc3ccccc3C2)[C@@H]1c4ccc(CO)cc4I)Sc5ccc(C)cc5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 I21 mock treatment 203760.0 -174000.0 -0.87 368320.0 15400.0 0.07 -0.5617 -0.6457 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 I22 mock treatment 278400.0 -98900.0 -0.49 202980.0 -150000.0 -0.71 -0.848 -0.9849 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 I23 compound treatment 247250.0 -130000.0 -0.65 292860.0 -60000.0 -0.28 -0.659 -0.9304 3186564 PK04_096179 OCc1ccc(cc1)[C@@H]2N(C3CCCCC3)C(=O)c4ccccc4[C@]52Cc6ccccc6N(CCN7CCOCC7)C5=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 I24 compound treatment 418560.0 41200.0 0.21 349880.0 -3020.0 -0.01 0.1356 0.6568 3068366 PK04_096180 CC(C)CNC(=O)[C@]1(CC(=O)N(C2Cc3ccccc3C2)[C@@H]1c4ccc(CO)cc4)Sc5ccc(C)cc5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 J01 compound treatment 11130.0 -366000.0 -1.83 7200.0 -346000.0 -1.63 -2.443 -0.9983 1230870 PK04_096181 Oc1cccc(c1)C(=O)CCN2CCOCC2 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 J02 compound treatment 432490.0 55200.0 0.28 163460.0 -189000.0 -0.89 -0.4352 -0.4666 3187207 PK04_096182 COC(=O)C1=CN(Cc2cccc(OC(F)(F)F)c2)C(C=C(CCCO)C=C1C(=O)OC)C3CC3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 J03 compound treatment 504650.0 127000.0 0.64 279960.0 -72900.0 -0.34 0.2071 0.2866 3068902 PK04_096183 COc1ccc(CC[C@H](O)c2cccc(OCC(=O)OC(C)(C)C)c2)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 J04 compound treatment 204770.0 -173000.0 -0.86 138400.0 -214000.0 -1.01 -1.3228 -0.9969 3187208 PK04_096184 CN1C(=O)C2C(C3C(N(Cc4cccc(OC(F)(F)F)c4)C2C=C3CCCO)c5cccs5)C1=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 J05 mock treatment 515090.0 138000.0 0.69 537000.0 184000.0 0.87 1.0989 0.9935 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 J06 mock treatment 225450.0 -152000.0 -0.76 477120.0 124000.0 0.58 -0.1232 -0.1287 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 J07 compound treatment 465520.0 88200.0 0.44 399460.0 46600.0 0.22 0.4664 0.948 3187209 PK04_096185 CCCN1C(=O)[C@@H]2Cc3c([nH]c4ccccc34)[C@H](N2C1=O)c5cccc(O)c5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 J08 compound treatment 163400.0 -214000.0 -1.07 205890.0 -147000.0 -0.69 -1.2444 -0.9778 3068903 PK04_096186 OCc1ccc(cc1)C2=CC(C3CC3)N(Cc4cc5OCOc5cc4Br)/C(=N\P(=O)(Oc6ccccc6)Oc7ccccc7)/C2 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 J09 compound treatment 336050.0 -41300.0 -0.21 451600.0 98700.0 0.46 0.1825 0.3594 1032549 PK04_096187 CCOC(=O)C1CCCCN1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 J10 compound treatment 193070.0 -184000.0 -0.92 255970.0 -96900.0 -0.46 -0.9731 -0.9475 3187210 PK04_096188 COc1cc2CCN(C)C(C=C)c2cc1O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 J11 compound treatment 459880.0 82600.0 0.41 240960.0 -112000.0 -0.53 -0.0807 -0.1207 3187211 PK04_096189 CCOC(=O)[C@@H]1CCCCN1C(=O)C(=O)OC 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 J12 compound treatment 459200.0 81900.0 0.41 214690.0 -138000.0 -0.65 -0.1705 -0.222 3187212 PK04_096190 COc1cc2CCN(Cc3ccc(o3)[N+](=O)[O-])C(c4ccc(CN5CCCC5)cc4)c2cc1O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 J13 compound treatment 383300.0 5980.0 0.03 166750.0 -186000.0 -0.88 -0.598 -0.6826 3068904 PK04_096191 [O-][N+](=O)c1cc(Br)ccc1C(=O)NCc2ccccc2 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 J14 compound treatment 338360.0 -39000.0 -0.19 199580.0 -153000.0 -0.72 -0.6475 -0.8669 3068905 PK04_096192 COc1cc2CCN(Cc3sc4ccccc4c3Cl)C(C=C)c2cc1O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 J15 compound treatment 550560.0 173000.0 0.87 380960.0 28100.0 0.13 0.7052 0.8056 3187213 PK04_096193 CC(=O)Nc1cc(Br)ccc1C(=O)O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 J16 compound treatment 443940.0 66600.0 0.33 355540.0 2640.0 0.01 0.2441 0.733 3187214 PK04_096194 COc1cc2CCN(Cc3sc4ccccc4c3Cl)C(c5cccs5)c2cc1O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 J17 compound treatment 533120.0 156000.0 0.78 300430.0 -52500.0 -0.25 0.3757 0.4602 3068906 PK04_096195 CC(=O)Nc1cc(Br)ccc1C(=O)NCc2ccccc2 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 J18 compound treatment 480650.0 103000.0 0.52 387570.0 34700.0 0.16 0.4803 0.8873 3187215 PK04_096196 COc1cc2CCN(Cc3cc4OCOc4cc3Br)C(c5cccs5)c2cc1O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 J19 compound treatment 485820.0 109000.0 0.54 394240.0 41300.0 0.19 0.5207 0.9044 3068907 PK04_096197 Brc1ccc2c(=O)oc(nc2c1)c3ccccc3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 J20 compound treatment 369490.0 -7830.0 -0.04 242090.0 -111000.0 -0.52 -0.3962 -0.758 3187216 PK04_096198 COc1cc2CCN(Cc3cccc(OC(F)(F)F)c3)C(c4ccc(CN5CCCC5)cc4)c2cc1O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 J21 mock treatment 533770.0 156000.0 0.78 406360.0 53500.0 0.25 0.7303 0.8897 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 J22 mock treatment 459650.0 82300.0 0.41 276180.0 -76700.0 -0.36 0.0356 0.0651 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 J23 compound treatment 311790.0 -65500.0 -0.33 364200.0 11300.0 0.05 -0.1938 -0.5846 3068908 PK04_096199 Nc1cc(Br)ccc1C(=O)O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 J24 compound treatment 210320.0 -167000.0 -0.83 189120.0 -164000.0 -0.77 -1.1345 -0.9992 3068910 PK04_096200 Oc1ccc2cc[n+](Cc3ccc(o3)[N+](=O)[O-])cc2c1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 K01 compound treatment 538920.0 162000.0 0.81 529760.0 177000.0 0.83 1.159 0.9999 3068198 PK04_096201 COc1ccccc1CN2[C@@H](c3ccc(CO)cc3)[C@]4(Cc5ccccc5N(Cc6ccccc6)C4=O)c7ccccc7C2=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 K02 compound treatment 549760.0 172000.0 0.86 536830.0 184000.0 0.87 1.2208 1.0 3186870 PK04_096202 Cc1ccc(S[C@@]2(CC(=O)N([C@@H]2c3ccc(CO)cc3)C4CCCCC4)C(=O)NCc5ccccc5)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 K03 compound treatment 188900.0 -188000.0 -0.94 187220.0 -166000.0 -0.78 -1.2165 -0.9956 3068155 PK04_096203 OCc1ccc(cc1)[C@@H]2N(Cc3ccccc3)C(=O)c4ccccc4[C@]2(Cc5ccccc5I)C(=O)NCC(F)(F)F 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 K04 compound treatment 500420.0 123000.0 0.61 196410.0 -156000.0 -0.74 -0.0857 -0.0894 3186875 PK04_096204 CC(C)N1[C@H](c2ccc(CO)cc2)[C@@](CC1=O)(Sc3ccc(C)cc3)C(=O)NCC(F)(F)F 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 K05 compound treatment 202910.0 -174000.0 -0.87 191140.0 -162000.0 -0.76 -1.154 -0.9977 3068359 PK04_096205 CC(C)N1[C@H](c2ccc(CO)cc2)[C@@](CC1=O)(Sc3ccc(C)cc3)C(=O)NC4CC4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 K06 compound treatment 244640.0 -133000.0 -0.66 422370.0 69500.0 0.33 -0.2375 -0.3215 3186626 PK04_096206 COc1ccccc1CN2[C@@H](c3ccc(CO)cc3)[C@]4(Cc5ccccc5N(CC(F)(F)F)C4=O)c6ccccc6C2=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 K07 mock treatment 207540.0 -170000.0 -0.85 388070.0 35200.0 0.17 -0.4826 -0.5586 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 K08 mock treatment 612650.0 235000.0 1.18 328730.0 -24200.0 -0.11 0.7507 0.6357 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 K09 compound treatment 220250.0 -157000.0 -0.78 168900.0 -184000.0 -0.87 -1.1667 -0.9988 3186869 PK04_096207 COc1ccc(CCNC(=O)[C@]2(CC(=O)N([C@@H]2c3ccc(CO)cc3)C4CCCCC4)Sc5ccc(C)cc5)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 K10 compound treatment 568760.0 191000.0 0.96 538790.0 186000.0 0.87 1.2944 0.999 3068235 PK04_096208 COCCCN1C(=O)[C@]2(Cc3ccccc13)[C@@H](N(Cc4ccccc4)C(=O)c5ccccc52)c6ccc(CO)cc6 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 K11 compound treatment 414830.0 37500.0 0.19 250770.0 -102000.0 -0.48 -0.2072 -0.4018 3186487 PK04_096209 OCc1ccc2[C@H]3N(CC4(CC5CC6CC(C5)C4)C6)C(=O)C[C@@]3(C(=O)N(Cc7ccccc7)c2c1)c8ccc(cc8)[N+](=O)[O-] 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 K12 compound treatment 145020.0 -232000.0 -1.16 515530.0 163000.0 0.76 -0.2795 -0.2011 3068411 PK04_096210 CCCNC(=O)[C@]1(CC(=O)N(Cc2ccccc2)[C@@H]1c3ccc(CO)cc3)Sc4ccc(C)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 K13 compound treatment 248530.0 -129000.0 -0.64 496000.0 143000.0 0.67 0.0211 0.0227 3068329 PK04_096211 CC(C)NC(=O)[C@]1(CC(=O)N([C@@H]1c2ccc(CO)cc2)C3CCCCC3)Sc4ccc(C)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 K14 compound treatment 376490.0 -826.0 0.0 299970.0 -52900.0 -0.25 -0.179 -0.7187 3067608 PK04_096212 COCCCN1C(=O)[C@]2(CC(=O)N([C@@H]2c3ccc(CO)cc13)C4CCCCC4)c5ccc(cc5)[N+](=O)[O-] 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 K15 mock treatment 566980.0 190000.0 0.95 188800.0 -164000.0 -0.77 0.124 0.1015 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 K16 mock treatment 217730.0 -160000.0 -0.8 246370.0 -107000.0 -0.5 -0.9179 -0.975 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 K17 compound treatment 420090.0 42800.0 0.21 383200.0 30300.0 0.14 0.2518 0.9806 3186979 PK04_096213 CC(C)NC(=O)[C@]1(CC(=O)N(Cc2cc(cc(c2)C(F)(F)F)C(F)(F)F)[C@@H]1c3ccc(CO)cc3)Sc4ccc(C)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 K18 compound treatment 358360.0 -19000.0 -0.09 533050.0 180000.0 0.85 0.5322 0.6242 3186636 PK04_096214 COCCCN1C(=O)[C@]2(Cc3ccccc13)[C@@H](N(Cc4ccccc4C(F)(F)F)C(=O)c5ccccc52)c6ccc(CO)cc6 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 K19 compound treatment 155680.0 -222000.0 -1.11 174610.0 -178000.0 -0.84 -1.3757 -0.9906 3186793 PK04_096215 COc1ccc(CCNC(=O)[C@]2(CC(=O)N(Cc3ccccc3C(F)(F)F)[C@@H]2c4ccc(CO)cc4I)Sc5ccc(C)cc5)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 K20 compound treatment 558560.0 181000.0 0.91 504870.0 152000.0 0.71 1.1455 0.9932 3186637 PK04_096216 OCc1ccc(cc1)[C@@H]2N(Cc3ccccc3)C(=O)c4ccccc4[C@]52Cc6ccccc6N(C7CC7)C5=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 K21 compound treatment 421570.0 44300.0 0.22 250370.0 -103000.0 -0.48 -0.1847 -0.3482 3067613 PK04_096217 COc1ccc(CCN2C(=O)[C@]3(CC(=O)N(CC4(CC5CC6CC(C5)C4)C6)[C@@H]3c7ccc(CO)cc27)c8ccc(cc8)[N+](=O)[O-])cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 K22 compound treatment 312550.0 -64800.0 -0.32 305980.0 -46900.0 -0.22 -0.3848 -0.9826 3186873 PK04_096218 CCCNC(=O)[C@]1(CC(=O)N(C(C)C)[C@@H]1c2ccc(CO)cc2)Sc3ccc(C)cc3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 K23 mock treatment 326760.0 -50600.0 -0.25 252170.0 -101000.0 -0.47 -0.5136 -0.9566 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 K24 mock treatment 356450.0 -20900.0 -0.1 581360.0 228000.0 1.07 0.6862 0.6355 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 L01 compound treatment 563470.0 186000.0 0.93 523490.0 171000.0 0.8 1.2248 0.9973 3068940 PK04_096219 Cc1nc2cc(Br)ccc2c(=O)o1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 L02 compound treatment 186880.0 -190000.0 -0.95 356320.0 3420.0 0.02 -0.6612 -0.695 3187217 PK04_096220 COc1cc2CCN(Cc3cc4OCOc4cc3Br)C(c5ccc(CN6CCCC6)cc5)c2cc1O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 L03 compound treatment 539120.0 162000.0 0.81 503480.0 151000.0 0.71 1.0723 0.9978 3068941 PK04_096221 CC(C)c1nc2cc(Br)ccc2c(=O)o1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 L04 compound treatment 461860.0 84500.0 0.42 286650.0 -66200.0 -0.31 0.0782 0.1491 3068942 PK04_096222 COc1cc2CCN(Cc3sc4ccccc4c3Cl)C(C)c2cc1O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 L05 compound treatment 227130.0 -150000.0 -0.75 162290.0 -191000.0 -0.9 -1.1644 -0.9961 3187218 PK04_096223 Cc1nc2cc(Br)ccc2c(=O)n1Cc3cccc(O)c3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 L06 compound treatment 538590.0 161000.0 0.81 175200.0 -178000.0 -0.84 -0.0215 -0.0185 3068943 PK04_096224 COc1cc2CCN(C)C(c3cccs3)c2cc1O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 L07 mock treatment 250570.0 -127000.0 -0.63 235680.0 -117000.0 -0.55 -0.8375 -0.9976 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 L08 mock treatment 384110.0 6790.0 0.03 183790.0 -169000.0 -0.8 -0.5385 -0.6763 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 L09 compound treatment 433710.0 56400.0 0.28 242840.0 -110000.0 -0.52 -0.1669 -0.2832 3187219 PK04_096225 Oc1cccc(CNC(=O)c2ccc(Br)cc2NC(=O)c3ccccc3)c1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 L10 compound treatment 217600.0 -160000.0 -0.8 454310.0 101000.0 0.48 -0.2268 -0.244 3187220 PK04_096226 COC(=O)C1=CN(Cc2cc3OCOc3cc2Br)C(C=C(C=C1C(=O)OC)c4ccc(CO)cc4)C5CC5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 L11 compound treatment 568930.0 192000.0 0.96 424770.0 71900.0 0.34 0.9158 0.9022 3068944 PK04_096227 Oc1cccc(Cn2c(nc3cc(Br)ccc3c2=O)c4ccccc4)c1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 L12 compound treatment 488600.0 111000.0 0.56 236660.0 -116000.0 -0.55 0.0064 0.0082 3187221 PK04_096228 CN1C(=O)C2C(C3C(N(Cc4cc5OCOc5cc4Br)C2C=C3CCCO)c6ccc(CN7CCCC7)cc6)C1=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 L13 compound treatment 477130.0 99800.0 0.5 199440.0 -153000.0 -0.72 -0.1579 -0.18 1980253 PK04_096229 Cc1c(NC(=O)/C(=C/C=C/c2ccccc2)/C#N)c(=O)n(c3ccccc3)n1C 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 L14 compound treatment 154300.0 -223000.0 -1.11 176640.0 -176000.0 -0.83 -1.3739 -0.9894 3068945 PK04_096230 COC(=O)C1=CN(Cc2cccc(OC(F)(F)F)c2)C(C=C(CCCO)C=C1C(=O)OC)c3cccs3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 L15 mock treatment 253290.0 -124000.0 -0.62 226650.0 -126000.0 -0.59 -0.8579 -0.9998 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 L16 mock treatment 405490.0 28200.0 0.14 582560.0 230000.0 1.08 0.8633 0.7925 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 L17 compound treatment 92190.0 -285000.0 -1.42 84960.0 -268000.0 -1.26 -1.8981 -0.9981 3187222 PK04_096231 Cc1c(NC(=O)/C(=C/C=C/c2ccccc2[N+](=O)[O-])/C#N)c(=O)n(c3ccccc3)n1C 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 L18 compound treatment 210940.0 -166000.0 -0.83 185230.0 -168000.0 -0.79 -1.1453 -0.9997 3187223 PK04_096232 OCCCC1=CC(N(Cc2cc3OCOc3cc2Br)/C(=N\P(=O)(Oc4ccccc4)Oc5ccccc5)/C1)c6cccs6 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 L19 compound treatment 122280.0 -255000.0 -1.27 157920.0 -195000.0 -0.92 -1.5492 -0.987 3068946 PK04_096233 Cc1c(NC(=O)/C(=C/C=C/c2ccc(cc2)[N+](=O)[O-])/C#N)c(=O)n(c3ccccc3)n1C 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 L20 compound treatment 219050.0 -158000.0 -0.79 253920.0 -99000.0 -0.47 -0.8881 -0.9681 3187224 PK04_096234 OCCCC1=CC(N(Cc2cccc(OC(F)(F)F)c2)/C(=N\P(=O)(Oc3ccccc3)Oc4ccccc4)/C1)c5cccs5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 L21 compound treatment 210450.0 -167000.0 -0.83 257880.0 -95000.0 -0.45 -0.9053 -0.9573 3068947 PK04_096235 CN(C)c1ccc(/C=C/C=C(\C#N)/C(=O)Nc2c(C)n(C)n(c3ccccc3)c2=O)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 L22 compound treatment 418000.0 40700.0 0.2 340320.0 -12600.0 -0.06 0.1018 0.4812 3187225 PK04_096236 COc1cc2CCN(C)C(C3CC3)c2cc1O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 L23 mock treatment 268190.0 -109000.0 -0.55 189350.0 -164000.0 -0.77 -0.9294 -0.9858 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 L24 mock treatment 208960.0 -168000.0 -0.84 340600.0 -12300.0 -0.06 -0.6355 -0.754 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 M01 compound treatment 500480.0 123000.0 0.62 176980.0 -176000.0 -0.83 -0.1501 -0.1456 3186502 PK04_096237 OCc1ccc(cc1)[C@@H]2N(Cc3ccccc3Cl)C(=O)c4ccccc4[C@]2(Cc5ccccc5I)C(=O)NCc6ccccc6 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 M02 compound treatment 209520.0 -168000.0 -0.84 176160.0 -177000.0 -0.83 -1.1804 -1.0 3186497 PK04_096238 COc1ccccc1CN2[C@@H](c3ccc(CO)cc3)[C@@](Cc4ccccc4I)(C(=O)NC(C)C)c5ccccc5C2=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 M03 compound treatment 457200.0 79900.0 0.4 535460.0 183000.0 0.86 0.8893 0.9392 3068404 PK04_096239 COCCCNC(=O)[C@]1(CC(=O)N(Cc2ccccc2C(F)(F)F)[C@@H]1c3ccc(CO)cc3)Sc4ccc(C)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 M04 compound treatment 170240.0 -207000.0 -1.03 134340.0 -219000.0 -1.03 -1.4582 -1.0 3186643 PK04_096240 Cc1ccc(S[C@@]2(CC(=O)N([C@@H]2c3ccc(CO)cc3I)C4CCCCC4)C(=O)NC5CC5)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 M05 compound treatment 221670.0 -156000.0 -0.78 160810.0 -192000.0 -0.9 -1.1886 -0.9972 3186723 PK04_096241 CCCNC(=O)[C@]1(CC(=O)N(Cc2ccccc2Cl)[C@@H]1c3ccc(CO)cc3I)Sc4ccc(C)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 M06 compound treatment 306940.0 -70400.0 -0.35 432680.0 79800.0 0.38 0.0168 0.0327 3186868 PK04_096242 Cc1ccc(S[C@@]2(CC(=O)N([C@@H]2c3ccc(CO)cc3)C4CCCCC4)C(=O)NC5CC5)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 M07 compound treatment 242340.0 -135000.0 -0.67 247740.0 -105000.0 -0.49 -0.8264 -0.9884 3186798 PK04_096243 CC(C)NC(=O)[C@]1(CC(=O)N(Cc2cc(cc(c2)C(F)(F)F)C(F)(F)F)[C@@H]1c3ccc(CO)cc3I)Sc4ccc(C)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 M08 compound treatment 231120.0 -146000.0 -0.73 188210.0 -165000.0 -0.77 -1.0641 -0.9996 3186799 PK04_096244 CN(C)CCCNC(=O)[C@]1(CC(=O)N(Cc2cc(cc(c2)C(F)(F)F)C(F)(F)F)[C@@H]1c3ccc(CO)cc3I)Sc4ccc(C)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 M09 mock treatment 442150.0 64800.0 0.32 164540.0 -188000.0 -0.89 -0.3975 -0.4214 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 M10 mock treatment 498040.0 121000.0 0.6 526000.0 173000.0 0.81 1.0021 0.9891 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 M11 compound treatment 208340.0 -169000.0 -0.84 198740.0 -154000.0 -0.73 -1.1095 -0.9971 3186496 PK04_096245 COc1ccc(CCNC(=O)[C@]2(Cc3ccccc3I)[C@@H](N(Cc4ccccc4OC)C(=O)c5ccccc52)c6ccc(CO)cc6)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 M12 compound treatment 545690.0 168000.0 0.84 412070.0 59200.0 0.28 0.7914 0.8935 3068379 PK04_096246 Cc1ccc(S[C@@]2(CC(=O)N(Cc3ccccc3C(F)(F)F)[C@@H]2c4ccc(CO)cc4)C(=O)NCCN5CCOCC5)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 M13 mock treatment 227970.0 -149000.0 -0.75 319870.0 -33000.0 -0.16 -0.6373 -0.8364 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 M14 mock treatment 169990.0 -207000.0 -1.04 536490.0 184000.0 0.86 -0.1216 -0.0902 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 M15 compound treatment 197880.0 -179000.0 -0.9 553170.0 200000.0 0.94 0.0324 0.0249 3186488 PK04_096247 CC(C)N1C(=O)[C@]2(CC(=O)N(CC3(CC4CC5CC(C4)C3)C5)[C@@H]2c6ccc(CO)cc16)c7ccc(cc7)[N+](=O)[O-] 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 M16 compound treatment 282560.0 -94800.0 -0.47 273730.0 -79200.0 -0.37 -0.598 -0.993 3186886 PK04_096248 COc1ccc(CCNC(=O)[C@]2(CC(=O)N(Cc3ccccc3Cl)[C@@H]2c4ccc(CO)cc4)Sc5ccc(C)cc5)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 M17 compound treatment 509030.0 132000.0 0.66 344210.0 -8690.0 -0.04 0.4363 0.6619 3068154 PK04_096249 OCc1ccc(cc1)[C@@H]2N(Cc3ccccc3)C(=O)c4ccccc4[C@]2(Cc5ccccc5I)C(=O)NCc6ccccc6 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 M18 compound treatment 228120.0 -149000.0 -0.75 239360.0 -114000.0 -0.53 -0.9045 -0.9867 3068369 PK04_096250 Cc1ccc(S[C@@]2(CC(=O)N(C3Cc4ccccc4C3)[C@@H]2c5ccc(CO)cc5)C(=O)NCC(F)(F)F)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 M19 compound treatment 136360.0 -241000.0 -1.2 200480.0 -152000.0 -0.72 -1.3579 -0.9694 3186727 PK04_096251 Cc1ccc(S[C@@]2(CC(=O)N(Cc3ccccc3Cl)[C@@H]2c4ccc(CO)cc4I)C(=O)NCC(F)(F)F)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 M20 compound treatment 217160.0 -160000.0 -0.8 394150.0 41300.0 0.19 -0.4284 -0.5205 3186984 PK04_096252 COc1ccc(CCNC(=O)[C@]2(CC(=O)N(Cc3ccccc3)[C@@H]2c4ccc(CO)cc4)Sc5ccc(C)cc5)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 M21 compound treatment 267120.0 -110000.0 -0.55 317330.0 -35600.0 -0.17 -0.5075 -0.8822 3068372 PK04_096253 Cc1ccc(S[C@@]2(CC(=O)N(Cc3ccccc3Cl)[C@@H]2c4ccc(CO)cc4)C(=O)NC5CC5)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 M22 compound treatment 203690.0 -174000.0 -0.87 182480.0 -170000.0 -0.8 -1.18 -0.9992 3186721 PK04_096254 Cc1ccc(S[C@@]2(CC(=O)N(C3Cc4ccccc4C3)[C@@H]2c5ccc(CO)cc5I)C(=O)NCC(F)(F)F)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 M23 compound treatment 210720.0 -167000.0 -0.83 232320.0 -121000.0 -0.57 -0.9894 -0.9825 3068316 PK04_096255 Cc1ccc(S[C@@]2(CC(=O)N(Cc3cc(cc(c3)C(F)(F)F)C(F)(F)F)[C@@H]2c4ccc(CO)cc4I)C(=O)NCc5ccccc5)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 M24 compound treatment 231200.0 -146000.0 -0.73 211740.0 -141000.0 -0.66 -0.9855 -0.9989 3068283 PK04_096256 Cc1ccc(S[C@@]2(CC(=O)N(Cc3ccccc3C(F)(F)F)[C@@H]2c4ccc(CO)cc4I)C(=O)NC5CC5)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 N01 compound treatment 552450.0 175000.0 0.87 565120.0 212000.0 1.0 1.3244 0.9978 1694663 PK04_096257 Cc1c(NC(=O)CC#N)c(=O)n(c2ccccc2)n1C 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 N02 compound treatment 269370.0 -108000.0 -0.54 408560.0 55700.0 0.26 -0.1961 -0.3272 3187226 PK04_096258 COC(=O)C1=CN(Cc2cccc(OC(F)(F)F)c2)C(C)C=C(CCCO)C=C1C(=O)OC 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 N03 compound treatment 219200.0 -158000.0 -0.79 493530.0 141000.0 0.66 -0.0907 -0.088 3068949 PK04_096259 Cc1ccccc1/C=C/C=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 N04 compound treatment 454360.0 77000.0 0.38 162840.0 -190000.0 -0.89 -0.36 -0.3699 3187227 PK04_096260 COC(=O)C1=CN(C)C(C=C(CCCO)C=C1C(=O)OC)c2ccc(CN3CCCC3)cc2 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 N05 compound treatment 329400.0 -47900.0 -0.24 479580.0 127000.0 0.6 0.2521 0.3926 3068950 PK04_096261 CCOc1ccc(cc1)N2C(SCC2=O)c3cccc(c3)[N+](=O)[O-] 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 N06 compound treatment 230310.0 -147000.0 -0.73 240640.0 -112000.0 -0.53 -0.8925 -0.9869 3187228 PK04_096262 Oc1ccc2cc[n+](Cc3cccc(OC(F)(F)F)c3)cc2c1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 N07 compound treatment 205060.0 -172000.0 -0.86 205160.0 -148000.0 -0.69 -1.0997 -0.9944 3068951 PK04_096263 [O-][N+](=O)c1cccc(c1)C2SCC(=O)N2c3ccccc3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 N08 compound treatment 176370.0 -201000.0 -1.0 337520.0 -15400.0 -0.07 -0.7608 -0.7561 3187299 PK04_096264 CN1C(=O)C2C(C3C(N(C)C2C=C3CCCO)c4cccs4)C1=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 N09 mock treatment 535310.0 158000.0 0.79 200680.0 -152000.0 -0.72 0.0517 0.0485 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 N10 mock treatment 430240.0 52900.0 0.26 214080.0 -139000.0 -0.65 -0.2748 -0.3901 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 N11 compound treatment 164810.0 -213000.0 -1.06 199290.0 -154000.0 -0.72 -1.2614 -0.9824 3068985 PK04_096265 Cc1cc(C)cc(c1)N2C(SCC2=O)c3cccc(c3)[N+](=O)[O-] 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 N12 compound treatment 457350.0 80000.0 0.4 344170.0 -8730.0 -0.04 0.2536 0.6311 3187300 PK04_096266 COc1cc2CCN(C)C(c3ccc(CN4CCCC4)cc3)c2cc1O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 N13 mock treatment 554840.0 178000.0 0.89 231220.0 -122000.0 -0.57 0.2222 0.2106 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 N14 mock treatment 485370.0 108000.0 0.54 225600.0 -127000.0 -0.6 -0.0418 -0.0518 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 N15 compound treatment 178130.0 -199000.0 -0.99 187950.0 -165000.0 -0.78 -1.2521 -0.9924 3068986 PK04_096267 COc1ccc(/C=C/C=O)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 N16 compound treatment 159360.0 -218000.0 -1.09 225860.0 -127000.0 -0.6 -1.1923 -0.9601 3187301 PK04_096268 OCCCC1=CC(C2CC2)N(Cc3sc4ccccc4c3Cl)/C(=N\P(=O)(Oc5ccccc5)Oc6ccccc6)/C1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 N17 compound treatment 223390.0 -154000.0 -0.77 202100.0 -151000.0 -0.71 -1.0452 -0.9992 3068987 PK04_096269 Cc1cccc(/C=C/C=O)c1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 N18 compound treatment 385920.0 8600.0 0.04 426460.0 73600.0 0.35 0.275 0.7889 3068988 PK04_096270 OCCCc1cc[n+](Cc2sc3ccccc3c2Cl)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 N19 compound treatment 164920.0 -212000.0 -1.06 280340.0 -72600.0 -0.34 -0.9914 -0.8897 3068989 PK04_096271 Cc1ccc(/C=C/C=O)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 N20 compound treatment 124130.0 -253000.0 -1.26 142040.0 -211000.0 -0.99 -1.5955 -0.9928 3187302 PK04_096272 CN1C(=O)C2C(C3C(C4CC4)N(Cc5sc6ccccc6c5Cl)C2C=C3c7ccc(CO)cc7)C1=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 N21 compound treatment 149190.0 -228000.0 -1.14 160100.0 -193000.0 -0.91 -1.4469 -0.9936 3068990 PK04_096273 COc1cccc(/C=C/C=O)c1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 N22 compound treatment 245820.0 -131000.0 -0.66 352800.0 -99.8 0.0 -0.4647 -0.7076 3068991 PK04_096274 Oc1ccc2cc[n+](Cc3cc4OCOc4cc3Br)cc2c1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 N23 compound treatment 181130.0 -196000.0 -0.98 242040.0 -111000.0 -0.52 -1.0616 -0.9564 3187303 PK04_096275 Clc1ccccc1/C=C/C=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 N24 compound treatment 360480.0 -16800.0 -0.08 245520.0 -107000.0 -0.51 -0.4166 -0.8136 3187304 PK04_096276 CN/1C(C=C(C\C1=N\P(=O)(Oc2ccccc2)Oc3ccccc3)c4ccc(CO)cc4)C5CC5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 O01 compound treatment 477840.0 101000.0 0.5 509890.0 157000.0 0.74 0.8772 0.9823 3186631 PK04_096277 CC(C)CN1C(=O)[C@]2(Cc3ccccc13)[C@@H](N(Cc4ccccc4C(F)(F)F)C(=O)c5ccccc52)c6ccc(CO)cc6 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 O02 compound treatment 531390.0 154000.0 0.77 539760.0 187000.0 0.88 1.1656 0.9978 3067615 PK04_096278 OCc1ccc2[C@H]3N(CC4(CC5CC6CC(C5)C4)C6)C(=O)C[C@@]3(C(=O)N(CC(F)(F)F)c2c1)c7ccc(cc7)[N+](=O)[O-] 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 O03 compound treatment 164240.0 -213000.0 -1.06 224510.0 -128000.0 -0.6 -1.1795 -0.964 3186715 PK04_096279 CC(C)N1[C@H](c2ccc(CO)cc2I)[C@@](CC1=O)(Sc3ccc(C)cc3)C(=O)NCCCN(C)C 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 O04 compound treatment 227170.0 -150000.0 -0.75 269920.0 -83000.0 -0.39 -0.8063 -0.9537 3068363 PK04_096280 CC(C)NC(=O)[C@]1(CC(=O)N(C(C)C)[C@@H]1c2ccc(CO)cc2)Sc3ccc(C)cc3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 O05 compound treatment 220370.0 -157000.0 -0.78 207170.0 -146000.0 -0.69 -1.039 -0.9978 3068310 PK04_096281 Cc1ccc(S[C@@]2(CC(=O)N(Cc3ccccc3C(F)(F)F)[C@@H]2c4ccc(CO)cc4I)C(=O)NCC(F)(F)F)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 O06 compound treatment 286080.0 -91200.0 -0.46 280520.0 -72400.0 -0.34 -0.5629 -0.9897 3068196 PK04_096282 COc1ccccc1CN2[C@@H](c3ccc(CO)cc3)[C@]4(Cc5ccccc5N(CCN6CCOCC6)C4=O)c7ccccc7C2=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 O07 compound treatment 219450.0 -158000.0 -0.79 188160.0 -165000.0 -0.77 -1.1055 -1.0 3068277 PK04_096283 COc1ccc(CCNC(=O)[C@]2(CC(=O)N(Cc3ccccc3Cl)[C@@H]2c4ccc(CO)cc4I)Sc5ccc(C)cc5)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 O08 compound treatment 186670.0 -191000.0 -0.95 190040.0 -163000.0 -0.77 -1.215 -0.9942 3186720 PK04_096284 CC(C)NC(=O)[C@]1(CC(=O)N(C2Cc3ccccc3C2)[C@@H]1c4ccc(CO)cc4I)Sc5ccc(C)cc5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 O09 compound treatment 473880.0 96600.0 0.48 244320.0 -109000.0 -0.51 -0.0201 -0.0286 3186632 PK04_096285 OCc1ccc(cc1)[C@@H]2N(Cc3ccccc3C(F)(F)F)C(=O)c4ccccc4[C@]52Cc6ccccc6N(CCN7CCOCC7)C5=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 O10 compound treatment 195410.0 -182000.0 -0.91 304690.0 -48200.0 -0.23 -0.8028 -0.8573 3068157 PK04_096286 COc1ccc(CCN2C(=O)[C@]3(Cc4ccccc24)[C@@H](N(C5CCCCC5)C(=O)c6ccccc63)c7ccc(CO)cc7)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 O11 mock treatment 380160.0 2840.0 0.01 518100.0 165000.0 0.78 0.5595 0.7199 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 O12 mock treatment 417160.0 39800.0 0.2 275270.0 -77600.0 -0.37 -0.1175 -0.2825 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 O13 compound treatment 387230.0 9910.0 0.05 340380.0 -12500.0 -0.06 -0.0066 -0.0862 3186874 PK04_096287 CC(C)N1[C@H](c2ccc(CO)cc2)[C@@](CC1=O)(Sc3ccc(C)cc3)C(=O)NCc4ccccc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 O14 compound treatment 262370.0 -115000.0 -0.57 217600.0 -135000.0 -0.64 -0.856 -0.9987 3068138 PK04_096288 COCCCN1C(=O)[C@]2(CC(=O)N(CC3(CC4CC5CC(C4)C3)C5)[C@@H]2c6ccc(CO)cc16)c7ccc(cc7)[N+](=O)[O-] 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 O15 compound treatment 341540.0 -35800.0 -0.18 486430.0 134000.0 0.63 0.3178 0.4866 3186972 PK04_096289 CC(C)CNC(=O)[C@]1(CC(=O)N(Cc2ccccc2C(F)(F)F)[C@@H]1c3ccc(CO)cc3)Sc4ccc(C)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 O16 compound treatment 415280.0 38000.0 0.19 410360.0 57500.0 0.27 0.3252 0.985 3186981 PK04_096290 COCCCNC(=O)[C@]1(CC(=O)N(Cc2cc(cc(c2)C(F)(F)F)C(F)(F)F)[C@@H]1c3ccc(CO)cc3)Sc4ccc(C)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 O17 compound treatment 116970.0 -260000.0 -1.3 177790.0 -175000.0 -0.82 -1.5019 -0.9757 3186709 PK04_096291 Cc1ccc(S[C@@]2(CC(=O)N([C@@H]2c3ccc(CO)cc3I)C4CCCCC4)C(=O)NCc5ccccc5)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 O18 compound treatment 224730.0 -153000.0 -0.76 216890.0 -136000.0 -0.64 -0.9912 -0.9962 3186725 PK04_096292 Cc1ccc(S[C@@]2(CC(=O)N(Cc3ccccc3Cl)[C@@H]2c4ccc(CO)cc4I)C(=O)NCCN5CCOCC5)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 O19 compound treatment 215040.0 -162000.0 -0.81 164020.0 -189000.0 -0.89 -1.2013 -0.9989 3068321 PK04_096293 Cc1ccc(S[C@@]2(CC(=O)N(Cc3ccccc3)[C@@H]2c4ccc(CO)cc4I)C(=O)NC5CC5)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 O20 compound treatment 346190.0 -31100.0 -0.16 232700.0 -120000.0 -0.57 -0.5097 -0.8693 3068192 PK04_096294 COCCCN1C(=O)[C@]2(Cc3ccccc13)[C@@H](N(C4CCCCC4)C(=O)c5ccccc52)c6ccc(CO)cc6 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 O21 compound treatment 234300.0 -143000.0 -0.71 314770.0 -38100.0 -0.18 -0.6319 -0.858 3068201 PK04_096295 OCc1ccc(cc1)[C@@H]2N(Cc3ccccc3Cl)C(=O)c4ccccc4[C@]52Cc6ccccc6N(C7CC7)C5=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 O22 compound treatment 353130.0 -24200.0 -0.12 278270.0 -74600.0 -0.35 -0.3336 -0.8987 3068381 PK04_096296 CC(C)NC(=O)[C@]1(CC(=O)N(Cc2ccccc2C(F)(F)F)[C@@H]1c3ccc(CO)cc3)Sc4ccc(C)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 O23 compound treatment 326020.0 -51300.0 -0.26 275870.0 -77000.0 -0.36 -0.4374 -0.9856 3186880 PK04_096297 Cc1ccc(S[C@@]2(CC(=O)N(C3Cc4ccccc4C3)[C@@H]2c5ccc(CO)cc5)C(=O)NCc6ccccc6)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 O24 compound treatment 493250.0 116000.0 0.58 206600.0 -146000.0 -0.69 -0.0772 -0.0858 3186977 PK04_096298 Cc1ccc(S[C@@]2(CC(=O)N(Cc3cc(cc(c3)C(F)(F)F)C(F)(F)F)[C@@H]2c4ccc(CO)cc4)C(=O)NCCN5CCOCC5)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 P01 compound treatment 250690.0 -127000.0 -0.63 248610.0 -104000.0 -0.49 -0.7941 -0.9921 3068992 PK04_096299 Cc1c(NC(=O)/C(=C/c2cccc(c2)[N+](=O)[O-])/C#N)c(=O)n(c3ccccc3)n1C 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 P02 compound treatment 217350.0 -160000.0 -0.8 162780.0 -190000.0 -0.89 -1.1973 -0.9984 3187305 PK04_096300 COC(=O)C1=CN(C)C(C=C(CCCO)C=C1C(=O)OC)C2CC2 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 P03 compound treatment 198450.0 -179000.0 -0.89 339070.0 -13800.0 -0.07 -0.6777 -0.7566 3187306 PK04_096301 COc1cccc(/C=C(\C#N)/C(=O)Nc2c(C)n(C)n(c3ccccc3)c2=O)c1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 P04 compound treatment 479200.0 102000.0 0.51 187720.0 -165000.0 -0.78 -0.1896 -0.2041 3068993 PK04_096302 COc1cc2CC[N+](=Cc2cc1O)C 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 P05 compound treatment 185210.0 -192000.0 -0.96 268000.0 -84900.0 -0.4 -0.9608 -0.9245 3068994 PK04_096303 Cc1c(NC(=O)/C(=C/c2ccccc2Cl)/C#N)c(=O)n(c3ccccc3)n1C 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 P06 compound treatment 191780.0 -186000.0 -0.93 369630.0 16700.0 0.08 -0.5996 -0.6447 3187307 PK04_096304 COc1cc2CCN(Cc3cccc(OC(F)(F)F)c3)C(c4cccs4)c2cc1O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 P07 compound treatment 229600.0 -148000.0 -0.74 364610.0 11700.0 0.06 -0.4827 -0.6525 3187308 PK04_096305 Cc1c(NC(=O)/C(=C/c2ccc(Cl)cc2)/C#N)c(=O)n(c3ccccc3)n1C 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 P08 compound treatment 238790.0 -139000.0 -0.69 384610.0 31700.0 0.15 -0.3838 -0.5422 3068995 PK04_096306 CN1C(=O)C2C(C3C(C4CC4)N(C)C2C=C3CCCO)C1=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 P09 compound treatment 188370.0 -189000.0 -0.94 187040.0 -166000.0 -0.78 -1.2189 -0.9955 1972122 PK04_096307 Cc1cc(C)cc(c1)N2C(c3cccc(c3)[N+](=O)[O-])S(=O)(=O)CC2=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 P10 compound treatment 158410.0 -219000.0 -1.09 166510.0 -186000.0 -0.88 -1.393 -0.994 3187309 PK04_096308 CN/1C(C=C(CCCO)C\C1=N\P(=O)(Oc2ccccc2)Oc3ccccc3)C4CC4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 P11 mock treatment 214210.0 -163000.0 -0.81 228510.0 -124000.0 -0.59 -0.9898 -0.9868 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 P12 mock treatment 244160.0 -133000.0 -0.67 160000.0 -193000.0 -0.91 -1.1118 -0.9883 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 P13 compound treatment 137150.0 -240000.0 -1.2 106670.0 -246000.0 -1.16 -1.6671 -0.9998 3068996 PK04_096309 Clc1ccc(/C=C/C=O)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 P14 compound treatment 302920.0 -74400.0 -0.37 154090.0 -199000.0 -0.94 -0.924 -0.9182 3187310 PK04_096310 COc1cc2CC[N+](=Cc2cc1O)Cc3cccc(OC(F)(F)F)c3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 P15 compound treatment 167130.0 -210000.0 -1.05 132480.0 -220000.0 -1.04 -1.4754 -1.0 3068997 PK04_096311 O=C/C=C/c1ccc2OCOc2c1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 P16 compound treatment 242400.0 -135000.0 -0.67 154670.0 -198000.0 -0.93 -1.1358 -0.9873 3187311 PK04_096312 COC(=O)C1=CN(Cc2cccc(OC(F)(F)F)c2)C(C=C(CCCO)C=C1C(=O)OC)c3ccc(CN4CCCC4)cc3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 P17 compound treatment 7770.0 -370000.0 -1.85 4600.0 -348000.0 -1.64 -2.4635 -0.9982 3068998 PK04_096313 O=C/C=C/c1ccc(cc1)c2ccccc2 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 P18 compound treatment 120680.0 -257000.0 -1.28 135630.0 -217000.0 -1.02 -1.629 -0.9937 3187312 PK04_096314 CN1C(=O)C2C(C3C(C4CC4)N(Cc5cc6OCOc6cc5Br)C2C=C3c7ccc(CO)cc7)C1=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 P19 compound treatment 22330.0 -355000.0 -1.77 5130.0 -348000.0 -1.64 -2.4104 -0.9992 3187313 PK04_096315 O=C/C=C/c1ccc(\C=C\c2ccccc2)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 P20 compound treatment 224830.0 -152000.0 -0.76 331780.0 -21100.0 -0.1 -0.6088 -0.7926 3187314 PK04_096316 COc1cc2CCN(Cc3ccc(o3)[N+](=O)[O-])C(c4cccs4)c2cc1O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 P21 compound treatment 293290.0 -84000.0 -0.42 240110.0 -113000.0 -0.53 -0.6719 -0.9933 3069028 PK04_096317 [O-][N+](=O)c1cccc(c1)C2N(C(=O)CS2(=O)=O)c3ccccc3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 P22 compound treatment 222970.0 -154000.0 -0.77 319040.0 -33900.0 -0.16 -0.6577 -0.8355 3187315 PK04_096318 COC(=O)C1=CN(Cc2sc3ccccc3c2Cl)C(C=C(CCCO)C=C1C(=O)OC)c4ccc(CN5CCCC5)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 P23 compound treatment 130640.0 -247000.0 -1.23 160090.0 -193000.0 -0.91 -1.5125 -0.9886 3069029 PK04_096319 CCOc1ccc(cc1)N2C(c3cccc(c3)[N+](=O)[O-])S(=O)(=O)/C(=C\C=C\c4ccccc4OC)/C2=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2096 P24 compound treatment 303390.0 -73900.0 -0.37 367450.0 14600.0 0.07 -0.2127 -0.5664 3187316 PK04_096320 COC(=O)C1=CN(C)C(C=C(C=C1C(=O)OC)c2ccc(CO)cc2)C3CC3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 A01 compound treatment 490240.0 109000.0 0.54 463410.0 138000.0 0.65 0.8436 0.9958 2141518 PK04_097001 NC(=O)NCC#Cc1ccc2NC(=O)[C@]3([C@@H]([C@@H]4N([C@@H]3c5ccc(OCCO)cc5)[C@H]([C@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)N)c2c1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 A02 compound treatment 211770.0 -170000.0 -0.85 340220.0 15200.0 0.07 -0.5496 -0.6451 2141905 PK04_097002 OCCOc1ccc(cc1)[C@H]2N3[C@@H]([C@@H](C(=O)N4CCN(CC4)c5ncccn5)[C@]26C(=O)Nc7ccccc76)C(=O)O[C@@H]([C@@H]3c8ccccc8)c9ccccc9 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 A03 compound treatment 149960.0 -232000.0 -1.16 119840.0 -205000.0 -0.96 -1.5009 -0.9959 2141091 PK04_097003 COc1ccc(C#Cc2ccc3NC(=O)[C@@]4([C@H]([C@H]5N([C@H]4c6ccc(OCCO)cc6)[C@@H]([C@@H](OC5=O)c7ccccc7)c8ccccc8)C(=O)O)c3c2)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 A04 compound treatment 164800.0 -217000.0 -1.08 139960.0 -185000.0 -0.87 -1.3815 -0.9941 2141692 PK04_097004 NC(=O)NCC#Cc1ccc2NC(=O)[C@]3([C@@H]([C@@H]4N([C@@H]3c5ccccc5OCCO)[C@H]([C@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)NC[C@H](O)c8ccccc8)c2c1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 A05 compound treatment 272640.0 -109000.0 -0.54 409920.0 84900.0 0.4 -0.1028 -0.1521 2141533 PK04_097005 COc1cc2CCN(Cc2cc1OC)C(=O)[C@@H]3[C@@H]4N([C@H](c5ccc(OCCO)cc5)[C@@]36C(=O)Nc7ccc(C#CCCO)cc76)[C@H]([C@H](OC4=O)c8ccccc8)c9ccccc9 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 A06 compound treatment 9570.0 -372000.0 -1.86 9520.0 -315000.0 -1.48 -2.3636 -0.9938 2141714 PK04_097006 COC(=O)C(CC#Cc1ccc2NC(=O)[C@]3([C@@H]([C@@H]4N([C@@H]3c5ccccc5OCCO)[C@H]([C@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)NC[C@H](O)c8ccccc8)c2c1)C(=O)OC 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 A07 compound treatment 201410.0 -180000.0 -0.9 165220.0 -160000.0 -0.75 -1.1682 -0.996 2141463 PK04_097007 NC(=O)[C@H]1[C@H]2N([C@@H](c3ccc(O)cc3)[C@]14C(=O)Nc5ccc(C#CC6(O)CCCCCC6)cc54)[C@@H]([C@@H](OC2=O)c7ccccc7)c8ccccc8 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 A08 compound treatment 151420.0 -230000.0 -1.15 152210.0 -173000.0 -0.81 -1.388 -0.9855 2141076 PK04_097008 OCCOc1ccc(cc1)[C@@H]2N3[C@H]([C@H](C(=O)O)[C@@]24C(=O)Nc5ccccc54)C(=O)O[C@H]([C@H]3c6ccccc6)c7ccccc7 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 A09 compound treatment 427380.0 45600.0 0.23 195560.0 -129000.0 -0.61 -0.2693 -0.4142 2141109 PK04_097009 OCCOc1ccccc1[C@@H]2N3[C@H]([C@H](C(=O)O)[C@@]24C(=O)Nc5ccc(C#CCCO)cc54)C(=O)O[C@H]([C@H]3c6ccccc6)c7ccccc7 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 A10 compound treatment 228100.0 -154000.0 -0.77 143320.0 -182000.0 -0.85 -1.1468 -0.9986 2141546 PK04_097010 OCCOc1ccc(cc1)[C@H]2N3[C@@H]([C@@H](C(=O)NCC=C)[C@]24C(=O)Nc5ccc(C#CC6(O)CCCCCC6)cc54)C(=O)O[C@@H]([C@@H]3c7ccccc7)c8ccccc8 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 A11 compound treatment 160960.0 -221000.0 -1.1 185490.0 -139000.0 -0.66 -1.2437 -0.9693 2141079 PK04_097011 OC(=O)[C@H]1[C@H]2N([C@@H](c3ccc(O)cc3)[C@]14C(=O)Nc5ccccc54)[C@@H]([C@@H](OC2=O)c6ccccc6)c7ccccc7 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 A12 compound treatment 419950.0 38200.0 0.19 150630.0 -174000.0 -0.82 -0.4449 -0.5284 2141141 PK04_097012 COc1ccc(C#Cc2ccc3NC(=O)[C@]4([C@@H]([C@@H]5N([C@@H]4c6ccc(O)cc6)[C@H]([C@H](OC5=O)c7ccccc7)c8ccccc8)C(=O)O)c3c2)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 A13 mock treatment 169510.0 -212000.0 -1.06 177020.0 -148000.0 -0.7 -1.2416 -0.9792 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 A14 mock treatment 322670.0 -59100.0 -0.29 168330.0 -157000.0 -0.74 -0.7296 -0.9193 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 A15 compound treatment 144280.0 -237000.0 -1.19 174720.0 -150000.0 -0.71 -1.3384 -0.9694 2141882 PK04_097013 OCCOc1ccccc1[C@@H]2N3[C@H]([C@H](C(=O)Nc4nc5ccccc5s4)[C@@]26C(=O)Nc7ccccc76)C(=O)O[C@H]([C@H]3c8ccccc8)c9ccccc9 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 A16 compound treatment 426320.0 44600.0 0.22 287970.0 -37000.0 -0.17 0.0343 0.1215 2141936 PK04_097014 NC(=O)[C@@H]1[C@@H]2N([C@H](c3ccc(O)cc3)[C@@]14C(=O)Nc5ccccc54)[C@H]([C@H](OC2=O)c6ccccc6)c7ccccc7 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 A17 compound treatment 208320.0 -173000.0 -0.87 176890.0 -148000.0 -0.7 -1.105 -0.9942 2141372 PK04_097015 OCCOc1ccccc1[C@@H]2N3[C@H]([C@H](C(=O)N4CCCCCCC4)[C@@]25C(=O)Nc6ccc(C#CC7(O)CCCCCC7)cc65)C(=O)O[C@H]([C@H]3c8ccccc8)c9ccccc9 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 A18 compound treatment 369760.0 -12000.0 -0.06 231230.0 -93800.0 -0.44 -0.3541 -0.7957 2141092 PK04_097016 NC(=O)NCC#Cc1ccc2NC(=O)[C@@]3([C@H]([C@H]4N([C@H]3c5ccc(OCCO)cc5)[C@@H]([C@@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)O)c2c1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 A19 compound treatment 397230.0 15500.0 0.08 302150.0 -22800.0 -0.11 -0.0212 -0.1603 2141344 PK04_097017 NC(=O)NCC#Cc1ccc2NC(=O)[C@@]3([C@H]([C@H]4N([C@H]3c5ccccc5OCCO)[C@@H]([C@@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)N8CCN(CC8)c9ncccn9)c2c1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 A20 compound treatment 361380.0 -20400.0 -0.1 227650.0 -97300.0 -0.46 -0.3956 -0.8436 2141115 PK04_097018 COc1ccc(C#Cc2ccc3NC(=O)[C@@]4([C@H]([C@H]5N([C@H]4c6ccc(O)cc6)[C@@H]([C@@H](OC5=O)c7ccccc7)c8ccccc8)C(=O)O)c3c2)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 A21 compound treatment 217010.0 -165000.0 -0.82 333030.0 8040.0 0.04 -0.555 -0.6739 2141570 PK04_097019 OCCOc1ccc(cc1)[C@H]2N3[C@@H]([C@@H](C(=O)N4CCCCCCC4)[C@]25C(=O)Nc6ccc(C#CC7=CCCCC7)cc65)C(=O)O[C@@H]([C@@H]3c8ccccc8)c9ccccc9 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 A22 compound treatment 249530.0 -132000.0 -0.66 273950.0 -51000.0 -0.24 -0.6366 -0.9062 2141549 PK04_097020 OCCOc1ccc(cc1)[C@H]2N3[C@@H]([C@@H](C(=O)NC[C@H](O)c4ccccc4)[C@]25C(=O)Nc6ccc(C#CC7(O)CCCCCC7)cc65)C(=O)O[C@@H]([C@@H]3c8ccccc8)c9ccccc9 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 A23 compound treatment 167970.0 -214000.0 -1.07 279950.0 -45000.0 -0.21 -0.9047 -0.8312 2141876 PK04_097021 OCCOc1ccccc1[C@@H]2N3[C@H]([C@H](C(=O)NCC=C)[C@@]24C(=O)Nc5ccccc54)C(=O)O[C@H]([C@H]3c6ccccc6)c7ccccc7 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 A24 compound treatment 166810.0 -215000.0 -1.07 256750.0 -68200.0 -0.32 -0.986 -0.88 2141753 PK04_097022 COc1cc2CCN(Cc2cc1OC)C(=O)[C@@H]3[C@@H]4N([C@H](c5ccccc5OCCO)[C@@]36C(=O)Nc7ccc(C#CC8=CCCCC8)cc76)[C@H]([C@H](OC4=O)c9ccccc9)c%10ccccc%10 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 B01 compound treatment 269650.0 -112000.0 -0.56 431390.0 106000.0 0.5 -0.0419 -0.0559 2141940 PK04_097023 COc1cc2CCN(Cc2cc1OC)C(=O)[C@@H]3[C@@H]4N([C@H](c5ccc(O)cc5)[C@@]36C(=O)Nc7ccccc76)[C@H]([C@H](OC4=O)c8ccccc8)c9ccccc9 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 B02 compound treatment 144500.0 -237000.0 -1.18 162120.0 -163000.0 -0.77 -1.3795 -0.9777 2142685 PK04_097024 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccccc4OCCO)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N)c7cc(C#CCCO)ccc17 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 B03 compound treatment 421050.0 39300.0 0.2 307000.0 -18000.0 -0.08 0.079 0.3696 2141335 PK04_097025 COc1ccc(C#Cc2ccc3NC(=O)[C@@]4([C@H]([C@H]5N([C@H]4c6ccccc6OCCO)[C@@H]([C@@H](OC5=O)c7ccccc7)c8ccccc8)C(=O)N9CCc%10cc(OC)c(OC)cc%10C9)c3c2)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 B04 compound treatment 368700.0 -13000.0 -0.07 417550.0 92600.0 0.44 0.2618 0.5948 2143933 PK04_097026 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccccc4OCCO)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCN(CC7)c8ncccn8)c9cc(C#CCNC(=O)N)ccc19 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 B05 compound treatment 417410.0 35700.0 0.18 451750.0 127000.0 0.6 0.5476 0.88 2141445 PK04_097027 COc1cc2CCN(Cc2cc1OC)C(=O)[C@H]3[C@H]4N([C@@H](c5ccc(O)cc5)[C@]36C(=O)Nc7ccc(C#CCCO)cc76)[C@@H]([C@@H](OC4=O)c8ccccc8)c9ccccc9 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 B06 compound treatment 374620.0 -7110.0 -0.04 157440.0 -168000.0 -0.79 -0.5824 -0.7382 2144925 PK04_097028 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(O)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NC[C@H](O)c7ccccc7)c8ccccc18 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 B07 compound treatment 119220.0 -263000.0 -1.31 140450.0 -185000.0 -0.87 -1.5409 -0.9799 2141881 PK04_097029 NC(=O)[C@H]1[C@H]2N([C@@H](c3ccccc3OCCO)[C@]14C(=O)Nc5ccccc54)[C@@H]([C@@H](OC2=O)c6ccccc6)c7ccccc7 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 B08 compound treatment 431260.0 49500.0 0.25 154880.0 -170000.0 -0.8 -0.3909 -0.4667 2144289 PK04_097030 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(O)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)Nc7nc8ccccc8s7)c9cc(C#CCCO)ccc19 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 B09 compound treatment 216550.0 -165000.0 -0.83 208000.0 -117000.0 -0.55 -0.9725 -0.9806 2141150 PK04_097031 COc1ccc(C#Cc2ccc3NC(=O)[C@@]4([C@H]([C@H]5N([C@H]4c6ccc(OCCO)cc6)[C@@H]([C@@H](OC5=O)c7ccccc7)c8ccccc8)C(=O)NCC=C)c3c2)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 B10 compound treatment 136180.0 -246000.0 -1.23 188640.0 -136000.0 -0.64 -1.3207 -0.9543 2144633 PK04_097032 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(OCCO)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NCC=C)c7ccccc17 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 B11 compound treatment 245140.0 -137000.0 -0.68 237560.0 -87400.0 -0.41 -0.7732 -0.9706 2141161 PK04_097033 NC(=O)NCC#Cc1ccc2NC(=O)[C@@]3([C@H]([C@H]4N([C@H]3c5ccc(OCCO)cc5)[C@@H]([C@@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)NCC=C)c2c1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 B12 compound treatment 433440.0 51700.0 0.26 325060.0 72.7 0.0 0.1829 0.708 2144765 PK04_097034 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(O)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NC[C@H](O)c7ccccc7)c8ccccc18 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 B13 mock treatment 486240.0 105000.0 0.52 383690.0 58700.0 0.28 0.5643 0.9557 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 B14 mock treatment 504270.0 123000.0 0.61 395730.0 70700.0 0.33 0.668 0.959 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 B15 compound treatment 278400.0 -103000.0 -0.52 357290.0 32300.0 0.15 -0.2575 -0.4786 2141135 PK04_097035 OCCOc1ccccc1[C@H]2N3[C@@H]([C@@H](C(=O)O)[C@]24C(=O)Nc5ccc(C#CCCO)cc54)C(=O)O[C@@H]([C@@H]3c6ccccc6)c7ccccc7 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 B16 compound treatment 410100.0 28400.0 0.14 183730.0 -141000.0 -0.66 -0.3696 -0.5441 2144753 PK04_097036 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(O)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NCC=C)c7ccccc17 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 B17 compound treatment 319840.0 -61900.0 -0.31 278750.0 -46200.0 -0.22 -0.3724 -0.9852 2141225 PK04_097037 COc1cc2CCN(Cc2cc1OC)C(=O)[C@H]3[C@H]4N([C@@H](c5ccc(OCCO)cc5)[C@]36C(=O)Nc7ccc(C#CC8=CCCCC8)cc76)[C@@H]([C@@H](OC4=O)c9ccccc9)c%10ccccc%10 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 B18 compound treatment 246030.0 -136000.0 -0.68 130800.0 -194000.0 -0.91 -1.1251 -0.9892 2144045 PK04_097038 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccccc4OCCO)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N)c7cc(C#CC8(O)CCCCCC8)ccc17 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 B19 compound treatment 264020.0 -118000.0 -0.59 325920.0 933.0 0.0 -0.4126 -0.7018 2141420 PK04_097039 COc1ccc(C#Cc2ccc3NC(=O)[C@@]4([C@H]([C@H]5N([C@H]4c6ccc(O)cc6)[C@@H]([C@@H](OC5=O)c7ccccc7)c8ccccc8)C(=O)Nc9nc%10ccccc%10s9)c3c2)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 B20 compound treatment 260550.0 -121000.0 -0.61 360420.0 35400.0 0.17 -0.3101 -0.494 2144377 PK04_097040 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(O)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCc8cc(OC)c(OC)cc8C7)c9cc(C#CC%10(O)CCCCCC%10)ccc19 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 B21 compound treatment 442730.0 61000.0 0.3 372610.0 47600.0 0.22 0.3738 0.9886 2141808 PK04_097041 COC(=O)C(CC#Cc1ccc2NC(=O)[C@]3([C@@H]([C@@H]4N([C@@H]3c5ccc(O)cc5)[C@H]([C@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)N8CCc9cc(OC)c(OC)cc9C8)c2c1)C(=O)OC 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 B22 compound treatment 251040.0 -131000.0 -0.65 281040.0 -43900.0 -0.21 -0.6077 -0.8876 2143265 PK04_097042 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(OCCO)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NCC=C)c7cc(C#CCNC(=O)N)ccc17 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 B23 compound treatment 234480.0 -147000.0 -0.74 224670.0 -100000.0 -0.47 -0.8537 -0.977 2141931 PK04_097043 Oc1ccc(cc1)[C@H]2N3[C@@H]([C@@H](C(=O)NCC=C)[C@]24C(=O)Nc5ccccc54)C(=O)O[C@@H]([C@@H]3c6ccccc6)c7ccccc7 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 B24 compound treatment 281220.0 -101000.0 -0.5 244340.0 -80600.0 -0.38 -0.6232 -0.9905 2142705 PK04_097044 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccccc4OCCO)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NCC=C)c7cc(C#CCC(C(=O)OC)C(=O)OC)ccc17 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 C01 compound treatment 327970.0 -53800.0 -0.27 339880.0 14900.0 0.07 -0.1403 -0.5057 2141223 PK04_097045 OCCOc1ccc(cc1)[C@@H]2N3[C@H]([C@H](C(=O)N4CCN(CC4)c5ncccn5)[C@@]26C(=O)Nc7ccc(C#CC8=CCCCC8)cc76)C(=O)O[C@H]([C@H]3c9ccccc9)c%10ccccc%10 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 C02 compound treatment 456810.0 75100.0 0.37 403690.0 78700.0 0.37 0.5269 1.0 2141108 PK04_097046 NC(=O)NCC#Cc1ccc2NC(=O)[C@@]3([C@H]([C@H]4N([C@H]3c5ccccc5OCCO)[C@@H]([C@@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)O)c2c1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 C03 compound treatment 152180.0 -230000.0 -1.15 175770.0 -149000.0 -0.7 -1.307 -0.9723 2141329 PK04_097047 COc1ccc(C#Cc2ccc3NC(=O)[C@@]4([C@H]([C@H]5N([C@H]4c6ccccc6OCCO)[C@@H]([C@@H](OC5=O)c7ccccc7)c8ccccc8)C(=O)NC[C@H](O)c9ccccc9)c3c2)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 C04 compound treatment 146820.0 -235000.0 -1.17 168160.0 -157000.0 -0.74 -1.3512 -0.975 2141703 PK04_097048 OCCOc1ccccc1[C@H]2N3[C@@H]([C@@H](C(=O)NC[C@H](O)c4ccccc4)[C@]25C(=O)Nc6ccc(C#CCCO)cc65)C(=O)O[C@@H]([C@@H]3c7ccccc7)c8ccccc8 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 C05 compound treatment 414190.0 32500.0 0.16 155620.0 -169000.0 -0.8 -0.4487 -0.5519 2065845 PK04_097049 NC(=O)NCC#Cc1ccc2NC(=O)[C@]3([C@@H]([C@@H]4N([C@@H]3c5ccc(OCCO)cc5)[C@H]([C@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)O)c2c1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 C06 compound treatment 410080.0 28300.0 0.14 231290.0 -93700.0 -0.44 -0.2115 -0.4569 2141782 PK04_097050 NC(=O)NCC#Cc1ccc2NC(=O)[C@]3([C@@H]([C@@H]4N([C@@H]3c5ccc(O)cc5)[C@H]([C@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)N)c2c1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 C07 compound treatment 369350.0 -12400.0 -0.06 322680.0 -2310.0 -0.01 -0.0514 -0.8187 2141574 PK04_097051 OCCOc1ccc(cc1)[C@H]2N3[C@@H]([C@@H](C(=O)Nc4nc5ccccc5s4)[C@]26C(=O)Nc7ccc(C#CC8=CCCCC8)cc76)C(=O)O[C@@H]([C@@H]3c9ccccc9)c%10ccccc%10 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 C08 compound treatment 188380.0 -193000.0 -0.97 190610.0 -134000.0 -0.63 -1.1298 -0.9789 2141856 PK04_097052 OCCOc1ccc(cc1)[C@@H]2N3[C@H]([C@H](C(=O)N4CCCCCCC4)[C@@]25C(=O)Nc6ccccc65)C(=O)O[C@H]([C@H]3c7ccccc7)c8ccccc8 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 C09 compound treatment 163250.0 -218000.0 -1.09 285980.0 -39000.0 -0.18 -0.9013 -0.8146 2141751 PK04_097053 OCCOc1ccccc1[C@H]2N3[C@@H]([C@@H](C(=O)N4CCN(CC4)c5ncccn5)[C@]26C(=O)Nc7ccc(C#CC8=CCCCC8)cc76)C(=O)O[C@@H]([C@@H]3c9ccccc9)c%10ccccc%10 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 C10 compound treatment 244710.0 -137000.0 -0.68 370370.0 45400.0 0.21 -0.333 -0.4645 2141441 PK04_097054 NC(=O)[C@H]1[C@H]2N([C@@H](c3ccc(O)cc3)[C@]14C(=O)Nc5ccc(C#CCCO)cc54)[C@@H]([C@@H](OC2=O)c6ccccc6)c7ccccc7 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 C11 mock treatment 414670.0 32900.0 0.16 178990.0 -146000.0 -0.69 -0.3693 -0.5229 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 C12 mock treatment 226030.0 -156000.0 -0.78 376070.0 51100.0 0.24 -0.38 -0.4669 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 C13 compound treatment 170560.0 -211000.0 -1.05 376390.0 51400.0 0.24 -0.5748 -0.5312 2141937 PK04_097055 Oc1ccc(cc1)[C@H]2N3[C@@H]([C@@H](C(=O)Nc4nc5ccccc5s4)[C@]26C(=O)Nc7ccccc76)C(=O)O[C@@H]([C@@H]3c8ccccc8)c9ccccc9 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 C14 compound treatment 31720.0 -350000.0 -1.75 78670.0 -246000.0 -1.16 -2.0554 -0.98 2141727 PK04_097056 NC(=O)[C@@H]1[C@@H]2N([C@H](c3ccccc3OCCO)[C@@]14C(=O)Nc5ccc(C#CC6(O)CCCCCC6)cc54)[C@H]([C@H](OC2=O)c7ccccc7)c8ccccc8 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 C15 mock treatment 403310.0 21600.0 0.11 358260.0 33300.0 0.16 0.1869 0.9834 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 C16 mock treatment 369010.0 -12700.0 -0.06 449030.0 124000.0 0.58 0.3676 0.6264 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 C17 compound treatment 466130.0 84400.0 0.42 297730.0 -27300.0 -0.13 0.2074 0.4707 2141078 PK04_097057 OCCOc1ccccc1[C@@H]2N3[C@H]([C@H](C(=O)O)[C@@]24C(=O)Nc5ccccc54)C(=O)O[C@H]([C@H]3c6ccccc6)c7ccccc7 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 C18 compound treatment 215440.0 -166000.0 -0.83 195270.0 -130000.0 -0.61 -1.0187 -0.9885 2141467 PK04_097058 COc1cc2CCN(Cc2cc1OC)C(=O)[C@H]3[C@H]4N([C@@H](c5ccc(O)cc5)[C@]36C(=O)Nc7ccc(C#CC8(O)CCCCCC8)cc76)[C@@H]([C@@H](OC4=O)c9ccccc9)c%10ccccc%10 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 C19 compound treatment 280190.0 -102000.0 -0.51 252560.0 -72400.0 -0.34 -0.5995 -0.9813 2141339 PK04_097059 NC(=O)NCC#Cc1ccc2NC(=O)[C@@]3([C@H]([C@H]4N([C@H]3c5ccccc5OCCO)[C@@H]([C@@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)N8CCCCCCC8)c2c1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 C20 compound treatment 18690.0 -363000.0 -1.81 11690.0 -313000.0 -1.47 -2.3242 -0.9947 2141364 PK04_097060 COC(=O)C(CC#Cc1ccc2NC(=O)[C@@]3([C@H]([C@H]4N([C@H]3c5ccccc5OCCO)[C@@H]([C@@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)N)c2c1)C(=O)OC 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 C21 compound treatment 194580.0 -187000.0 -0.93 187200.0 -138000.0 -0.65 -1.1192 -0.984 2141370 PK04_097061 OCCOc1ccccc1[C@@H]2N3[C@H]([C@H](C(=O)NCC=C)[C@@]24C(=O)Nc5ccc(C#CC6(O)CCCCCC6)cc54)C(=O)O[C@H]([C@H]3c7ccccc7)c8ccccc8 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 C22 compound treatment 296320.0 -85400.0 -0.43 353650.0 28700.0 0.13 -0.2063 -0.4612 2141489 PK04_097062 COc1cc2CCN(Cc2cc1OC)C(=O)[C@H]3[C@H]4N([C@@H](c5ccc(O)cc5)[C@]36C(=O)Nc7ccc(C#CC8=CCCCC8)cc76)[C@@H]([C@@H](OC4=O)c9ccccc9)c%10ccccc%10 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 C23 compound treatment 224180.0 -158000.0 -0.79 144420.0 -181000.0 -0.85 -1.157 -0.9993 2141706 PK04_097063 OCCOc1ccccc1[C@H]2N3[C@@H]([C@@H](C(=O)Nc4nc5ccccc5s4)[C@]26C(=O)Nc7ccc(C#CCCO)cc76)C(=O)O[C@@H]([C@@H]3c8ccccc8)c9ccccc9 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 C24 compound treatment 231170.0 -151000.0 -0.75 284080.0 -40900.0 -0.19 -0.6678 -0.8603 2141172 PK04_097064 OCCOc1ccc(cc1)[C@@H]2N3[C@H]([C@H](C(=O)NCC=C)[C@@]24C(=O)Nc5ccc(C#CCCO)cc54)C(=O)O[C@H]([C@H]3c6ccccc6)c7ccccc7 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 D01 compound treatment 520230.0 138000.0 0.69 481120.0 156000.0 0.73 1.0084 0.9996 2141788 PK04_097065 OCCC#Cc1ccc2NC(=O)[C@]3([C@@H]([C@@H]4N([C@@H]3c5ccc(O)cc5)[C@H]([C@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)NCC=C)c2c1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 D02 compound treatment 273440.0 -108000.0 -0.54 374640.0 49700.0 0.23 -0.2173 -0.3689 2143973 PK04_097066 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccccc4OCCO)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCN(CC7)c8ncccn8)c9cc(C#CCCO)ccc19 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 D03 compound treatment 398080.0 16300.0 0.08 231680.0 -93300.0 -0.44 -0.2526 -0.5659 2141854 PK04_097067 OCCOc1ccc(cc1)[C@@H]2N3[C@H]([C@H](C(=O)NCC=C)[C@@]24C(=O)Nc5ccccc54)C(=O)O[C@H]([C@H]3c6ccccc6)c7ccccc7 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 D04 compound treatment 246910.0 -135000.0 -0.67 161040.0 -164000.0 -0.77 -1.0214 -0.9977 2141969 PK04_097068 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(OCCO)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)Nc7nc8ccccc8s7)c9cc(C#Cc%10ccc(OC)cc%10)ccc19 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 D05 compound treatment 333920.0 -47800.0 -0.24 444170.0 119000.0 0.56 0.2275 0.3734 2141087 PK04_097069 OCCOc1ccc(cc1)[C@H]2N3[C@@H]([C@@H](C(=O)O)[C@]24C(=O)Nc5ccccc54)C(=O)O[C@@H]([C@@H]3c6ccccc6)c7ccccc7 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 D06 compound treatment 239200.0 -143000.0 -0.71 157000.0 -168000.0 -0.79 -1.0621 -0.9986 2144657 PK04_097070 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(OCCO)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)Nc7nc8ccccc8s7)c9ccccc19 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 D07 compound treatment 472910.0 91200.0 0.46 478490.0 154000.0 0.72 0.8326 0.9753 2141768 PK04_097071 COc1ccc(C#Cc2ccc3NC(=O)[C@]4([C@@H]([C@@H]5N([C@@H]4c6ccc(O)cc6)[C@H]([C@H](OC5=O)c7ccccc7)c8ccccc8)C(=O)N9CCCCCCC9)c3c2)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 D08 compound treatment 183770.0 -198000.0 -0.99 247590.0 -77400.0 -0.36 -0.9566 -0.9079 2144733 PK04_097072 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccccc4OCCO)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N)c7ccccc17 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 D09 compound treatment 195840.0 -186000.0 -0.93 190690.0 -134000.0 -0.63 -1.1032 -0.9824 2141552 PK04_097073 OCCOc1ccc(cc1)[C@H]2N3[C@@H]([C@@H](C(=O)Nc4nc5ccccc5s4)[C@]26C(=O)Nc7ccc(C#CC8(O)CCCCCC8)cc76)C(=O)O[C@@H]([C@@H]3c9ccccc9)c%10ccccc%10 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 D10 compound treatment 139860.0 -242000.0 -1.21 259940.0 -65000.0 -0.31 -1.0706 -0.8591 2143885 PK04_097074 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccccc4OCCO)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N)c7cc(C#Cc8ccc(OC)cc8)ccc17 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 D11 mock treatment 291590.0 -90100.0 -0.45 234120.0 -90900.0 -0.43 -0.6206 -0.9997 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 D12 mock treatment 476800.0 95100.0 0.47 380960.0 56000.0 0.26 0.5219 0.9613 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 D13 compound treatment 274420.0 -107000.0 -0.54 374120.0 49100.0 0.23 -0.2156 -0.3693 2141513 PK04_097075 NC(=O)NCC#Cc1ccc2NC(=O)[C@]3([C@@H]([C@@H]4N([C@@H]3c5ccc(OCCO)cc5)[C@H]([C@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)NCC=C)c2c1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 D14 compound treatment 234730.0 -147000.0 -0.73 286240.0 -38700.0 -0.18 -0.648 -0.8566 2144449 PK04_097076 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(O)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)Nc7nc8ccccc8s7)c9cc(C#CC%10=CCCCC%10)ccc19 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 D15 mock treatment 311250.0 -70500.0 -0.35 197920.0 -127000.0 -0.6 -0.6715 -0.9681 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 D16 mock treatment 298330.0 -83400.0 -0.42 426490.0 102000.0 0.48 0.043 0.0679 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 D17 compound treatment 265300.0 -116000.0 -0.58 226050.0 -98900.0 -0.47 -0.7403 -0.9939 2141816 PK04_097077 Oc1ccc(cc1)[C@H]2N3[C@@H]([C@@H](C(=O)Nc4nc5ccccc5s4)[C@]26C(=O)Nc7ccc(C#CC8(O)CCCCCC8)cc76)C(=O)O[C@@H]([C@@H]3c9ccccc9)c%10ccccc%10 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 D18 compound treatment 170400.0 -211000.0 -1.06 308000.0 -17000.0 -0.08 -0.8029 -0.7585 2142085 PK04_097078 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(OCCO)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N)c7cc(C#CCC(C(=O)OC)C(=O)OC)ccc17 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 D19 compound treatment 242730.0 -139000.0 -0.69 307410.0 -17600.0 -0.08 -0.5494 -0.7858 2141432 PK04_097079 NC(=O)NCC#Cc1ccc2NC(=O)[C@@]3([C@H]([C@H]4N([C@H]3c5ccc(O)cc5)[C@@H]([C@@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)N8CCN(CC8)c9ncccn9)c2c1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 D20 compound treatment 324210.0 -57500.0 -0.29 209810.0 -115000.0 -0.54 -0.5862 -0.956 2144825 PK04_097080 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(OCCO)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCc8cc(OC)c(OC)cc8C7)c9ccccc19 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 D21 compound treatment 282490.0 -99200.0 -0.5 199580.0 -125000.0 -0.59 -0.7676 -0.9963 2141123 PK04_097081 COc1ccc(C#Cc2ccc3NC(=O)[C@]4([C@@H]([C@@H]5N([C@@H]4c6ccc(OCCO)cc6)[C@H]([C@H](OC5=O)c7ccccc7)c8ccccc8)C(=O)O)c3c2)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 D22 compound treatment 179480.0 -202000.0 -1.01 226640.0 -98300.0 -0.46 -1.0414 -0.9373 2144893 PK04_097082 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccccc4OCCO)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N)c7ccccc17 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 D23 compound treatment 373200.0 -8530.0 -0.04 212050.0 -113000.0 -0.53 -0.4058 -0.7614 2141421 PK04_097083 COc1ccc(C#Cc2ccc3NC(=O)[C@@]4([C@H]([C@H]5N([C@H]4c6ccc(O)cc6)[C@@H]([C@@H](OC5=O)c7ccccc7)c8ccccc8)C(=O)N9CCN(CC9)c%10ncccn%10)c3c2)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 D24 compound treatment 212930.0 -169000.0 -0.84 377090.0 52100.0 0.25 -0.4229 -0.4816 2143085 PK04_097084 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(O)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N)c7cc(C#CC8(O)CCCCCC8)ccc17 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 E01 mock treatment 479100.0 97400.0 0.49 473030.0 148000.0 0.7 0.8363 0.9846 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 E02 mock treatment 461390.0 79700.0 0.4 477280.0 152000.0 0.72 0.7878 0.9615 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 E03 compound treatment 273790.0 -108000.0 -0.54 250110.0 -74900.0 -0.35 -0.6303 -0.9787 2141878 PK04_097085 OCCOc1ccccc1[C@@H]2N3[C@H]([C@H](C(=O)N4CCCCCCC4)[C@@]25C(=O)Nc6ccccc65)C(=O)O[C@H]([C@H]3c7ccccc7)c8ccccc8 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 E04 compound treatment 220360.0 -161000.0 -0.81 179560.0 -145000.0 -0.68 -1.0536 -0.9967 2141520 PK04_097086 NC(=O)NCC#Cc1ccc2NC(=O)[C@]3([C@@H]([C@@H]4N([C@@H]3c5ccc(OCCO)cc5)[C@H]([C@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)N8CCN(CC8)c9ncccn9)c2c1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 E05 compound treatment 256180.0 -126000.0 -0.63 310940.0 -14000.0 -0.07 -0.4901 -0.7773 2141359 PK04_097087 COC(=O)C(CC#Cc1ccc2NC(=O)[C@@]3([C@H]([C@H]4N([C@H]3c5ccccc5OCCO)[C@@H]([C@@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)NCC=C)c2c1)C(=O)OC 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 E06 compound treatment 246190.0 -136000.0 -0.68 138530.0 -186000.0 -0.88 -1.0988 -0.9918 2141507 PK04_097088 COc1ccc(C#Cc2ccc3NC(=O)[C@]4([C@@H]([C@@H]5N([C@@H]4c6ccc(OCCO)cc6)[C@H]([C@H](OC5=O)c7ccccc7)c8ccccc8)C(=O)N)c3c2)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 E07 compound treatment 329510.0 -52200.0 -0.26 279650.0 -45300.0 -0.21 -0.3352 -0.995 2141863 PK04_097089 COc1cc2CCN(Cc2cc1OC)C(=O)[C@H]3[C@H]4N([C@@H](c5ccc(OCCO)cc5)[C@]36C(=O)Nc7ccccc76)[C@@H]([C@@H](OC4=O)c8ccccc8)c9ccccc9 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 E08 compound treatment 436600.0 54900.0 0.27 341180.0 16200.0 0.08 0.2476 0.8706 2141163 PK04_097090 NC(=O)NCC#Cc1ccc2NC(=O)[C@@]3([C@H]([C@H]4N([C@H]3c5ccc(OCCO)cc5)[C@@H]([C@@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)N8CCCCCCC8)c2c1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 E09 mock treatment 475530.0 93800.0 0.47 394490.0 69500.0 0.33 0.5624 0.9845 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 E10 mock treatment 553230.0 171000.0 0.86 305250.0 -19700.0 -0.09 0.54 0.6268 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 E11 compound treatment 501600.0 120000.0 0.6 438140.0 113000.0 0.53 0.7997 0.9983 2141456 PK04_097091 COC(=O)C(CC#Cc1ccc2NC(=O)[C@@]3([C@H]([C@H]4N([C@H]3c5ccc(O)cc5)[C@@H]([C@@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)N8CCc9cc(OC)c(OC)cc9C8)c2c1)C(=O)OC 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 E12 compound treatment 83210.0 -299000.0 -1.49 112190.0 -213000.0 -1.0 -1.762 -0.9812 2141683 PK04_097092 COc1ccc(C#Cc2ccc3NC(=O)[C@]4([C@@H]([C@@H]5N([C@@H]4c6ccccc6OCCO)[C@H]([C@H](OC5=O)c7ccccc7)c8ccccc8)C(=O)N)c3c2)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 E13 compound treatment 168400.0 -213000.0 -1.07 206290.0 -119000.0 -0.56 -1.1482 -0.9545 2141357 PK04_097093 COc1cc2CCN(Cc2cc1OC)C(=O)[C@H]3[C@H]4N([C@@H](c5ccccc5OCCO)[C@]36C(=O)Nc7ccc(C#CCCO)cc76)[C@@H]([C@@H](OC4=O)c8ccccc8)c9ccccc9 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 E14 compound treatment 48480.0 -333000.0 -1.66 36800.0 -288000.0 -1.36 -2.1354 -0.9948 2141366 PK04_097094 COC(=O)C(CC#Cc1ccc2NC(=O)[C@@]3([C@H]([C@H]4N([C@H]3c5ccccc5OCCO)[C@@H]([C@@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)N8CCN(CC8)c9ncccn9)c2c1)C(=O)OC 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 E15 compound treatment 195800.0 -186000.0 -0.93 326250.0 1260.0 0.01 -0.6524 -0.7026 2141575 PK04_097095 OCCOc1ccc(cc1)[C@H]2N3[C@@H]([C@@H](C(=O)N4CCN(CC4)c5ncccn5)[C@]26C(=O)Nc7ccc(C#CC8=CCCCC8)cc76)C(=O)O[C@@H]([C@@H]3c9ccccc9)c%10ccccc%10 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 E16 compound treatment 424670.0 42900.0 0.21 418560.0 93600.0 0.44 0.4629 0.9454 2141485 PK04_097096 NC(=O)[C@H]1[C@H]2N([C@@H](c3ccc(O)cc3)[C@]14C(=O)Nc5ccc(C#CC6=CCCCC6)cc54)[C@@H]([C@@H](OC2=O)c7ccccc7)c8ccccc8 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 E17 mock treatment 394630.0 12900.0 0.06 332520.0 7530.0 0.04 0.0706 0.9604 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 E18 mock treatment 435650.0 53900.0 0.27 426730.0 102000.0 0.48 0.5288 0.963 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 E19 compound treatment 187450.0 -194000.0 -0.97 233180.0 -91800.0 -0.43 -0.9915 -0.9335 2141377 PK04_097097 OCCOc1ccccc1[C@@H]2N3[C@H]([C@H](C(=O)N4CCN(CC4)c5ncccn5)[C@@]26C(=O)Nc7ccc(C#CC8(O)CCCCCC8)cc76)C(=O)O[C@H]([C@H]3c9ccccc9)c%10ccccc%10 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 E20 compound treatment 191720.0 -190000.0 -0.95 186990.0 -138000.0 -0.65 -1.13 -0.9828 2141326 PK04_097098 COc1ccc(C#Cc2ccc3NC(=O)[C@@]4([C@H]([C@H]5N([C@H]4c6ccccc6OCCO)[C@@H]([C@@H](OC5=O)c7ccccc7)c8ccccc8)C(=O)NCC=C)c3c2)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 E21 compound treatment 230240.0 -151000.0 -0.76 194330.0 -131000.0 -0.61 -0.9696 -0.9947 2141702 PK04_097099 OCCOc1ccccc1[C@H]2N3[C@@H]([C@@H](C(=O)N4CCCCCCC4)[C@]25C(=O)Nc6ccc(C#CCCO)cc65)C(=O)O[C@@H]([C@@H]3c7ccccc7)c8ccccc8 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 E22 compound treatment 379390.0 -2340.0 -0.01 162680.0 -162000.0 -0.76 -0.5481 -0.7179 2141417 PK04_097100 COc1ccc(C#Cc2ccc3NC(=O)[C@@]4([C@H]([C@H]5N([C@H]4c6ccc(O)cc6)[C@@H]([C@@H](OC5=O)c7ccccc7)c8ccccc8)C(=O)NC[C@H](O)c9ccccc9)c3c2)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 E23 compound treatment 326960.0 -54800.0 -0.27 312880.0 -12100.0 -0.06 -0.2337 -0.8364 2141167 PK04_097101 NC(=O)NCC#Cc1ccc2NC(=O)[C@@]3([C@H]([C@H]4N([C@H]3c5ccc(OCCO)cc5)[C@@H]([C@@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)Nc8nc9ccccc9s8)c2c1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 E24 compound treatment 263680.0 -118000.0 -0.59 185150.0 -140000.0 -0.66 -0.882 -0.9985 2141113 PK04_097102 OCCOc1ccccc1[C@@H]2N3[C@H]([C@H](C(=O)O)[C@@]24C(=O)Nc5ccc(C#CC6=CCCCC6)cc54)C(=O)O[C@H]([C@H]3c7ccccc7)c8ccccc8 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 F01 mock treatment 484060.0 102000.0 0.51 462980.0 138000.0 0.65 0.8203 0.993 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 F02 mock treatment 491900.0 110000.0 0.55 440440.0 115000.0 0.54 0.7731 1.0 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 F03 compound treatment 151900.0 -230000.0 -1.15 201440.0 -124000.0 -0.58 -1.2226 -0.9502 2141216 PK04_097103 OCCOc1ccc(cc1)[C@@H]2N3[C@H]([C@H](C(=O)NCC=C)[C@@]24C(=O)Nc5ccc(C#CC6=CCCCC6)cc54)C(=O)O[C@H]([C@H]3c7ccccc7)c8ccccc8 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 F04 compound treatment 474400.0 92700.0 0.46 154340.0 -171000.0 -0.8 -0.2403 -0.2594 2142933 PK04_097104 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(O)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCN(CC7)c8ncccn8)c9cc(C#Cc%10ccc(OC)cc%10)ccc19 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 F05 compound treatment 139360.0 -242000.0 -1.21 94400.0 -231000.0 -1.08 -1.6229 -0.9985 2141355 PK04_097105 OCCOc1ccccc1[C@@H]2N3[C@H]([C@H](C(=O)N4CCN(CC4)c5ncccn5)[C@@]26C(=O)Nc7ccc(C#CCCO)cc76)C(=O)O[C@H]([C@H]3c8ccccc8)c9ccccc9 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 F06 compound treatment 172010.0 -210000.0 -1.05 162250.0 -163000.0 -0.77 -1.2819 -0.9881 2142833 PK04_097106 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccccc4OCCO)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCCCCCC7)c8cc(C#CC9=CCCCC9)ccc18 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 F07 compound treatment 225760.0 -156000.0 -0.78 420190.0 95200.0 0.45 -0.2342 -0.2606 2141414 PK04_097107 COc1ccc(C#Cc2ccc3NC(=O)[C@@]4([C@H]([C@H]5N([C@H]4c6ccc(O)cc6)[C@@H]([C@@H](OC5=O)c7ccccc7)c8ccccc8)C(=O)NCC=C)c3c2)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 F08 compound treatment 468730.0 87000.0 0.43 316650.0 -8340.0 -0.04 0.2795 0.6407 2144249 PK04_097108 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(O)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)Nc7nc8ccccc8s7)c9cc(C#CCNC(=O)N)ccc19 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 F09 mock treatment 467750.0 86000.0 0.43 468570.0 144000.0 0.68 0.7813 0.9762 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 F10 mock treatment 513540.0 132000.0 0.66 270740.0 -54200.0 -0.26 0.2851 0.4038 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 F11 compound treatment 165130.0 -217000.0 -1.08 137450.0 -188000.0 -0.88 -1.3887 -0.9949 2141568 PK04_097109 OCCOc1ccc(cc1)[C@H]2N3[C@@H]([C@@H](C(=O)NCC=C)[C@]24C(=O)Nc5ccc(C#CC6=CCCCC6)cc54)C(=O)O[C@@H]([C@@H]3c7ccccc7)c8ccccc8 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 F12 compound treatment 202020.0 -180000.0 -0.9 172170.0 -153000.0 -0.72 -1.143 -0.9939 2142765 PK04_097110 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccccc4OCCO)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N)c7cc(C#CC8(O)CCCCCC8)ccc17 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 F13 compound treatment 297400.0 -84300.0 -0.42 246140.0 -78800.0 -0.37 -0.5601 -0.998 2141348 PK04_097111 OCCOc1ccccc1[C@@H]2N3[C@H]([C@H](C(=O)NCC=C)[C@@]24C(=O)Nc5ccc(C#CCCO)cc54)C(=O)O[C@H]([C@H]3c6ccccc6)c7ccccc7 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 F14 compound treatment 222010.0 -160000.0 -0.8 452160.0 127000.0 0.6 -0.1411 -0.1415 2142645 PK04_097112 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccccc4OCCO)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N)c7cc(C#CCNC(=O)N)ccc17 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 F15 compound treatment 330930.0 -50800.0 -0.25 196110.0 -129000.0 -0.61 -0.6081 -0.9253 2141505 PK04_097113 COc1ccc(C#Cc2ccc3NC(=O)[C@]4([C@@H]([C@@H]5N([C@@H]4c6ccc(OCCO)cc6)[C@H]([C@H](OC5=O)c7ccccc7)c8ccccc8)C(=O)NC[C@H](O)c9ccccc9)c3c2)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 F16 compound treatment 231330.0 -150000.0 -0.75 376080.0 51100.0 0.24 -0.3612 -0.458 2142977 PK04_097114 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(O)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCc8cc(OC)c(OC)cc8C7)c9cc(C#CCNC(=O)N)ccc19 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 F17 mock treatment 200850.0 -181000.0 -0.9 261220.0 -63800.0 -0.3 -0.8509 -0.8939 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 F18 mock treatment 454430.0 72700.0 0.36 404280.0 79300.0 0.37 0.5205 0.9999 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 F19 compound treatment 181440.0 -200000.0 -1.0 327550.0 2560.0 0.01 -0.6988 -0.6985 2141200 PK04_097115 OCCOc1ccc(cc1)[C@@H]2N3[C@H]([C@H](C(=O)Nc4nc5ccccc5s4)[C@@]26C(=O)Nc7ccc(C#CC8(O)CCCCCC8)cc76)C(=O)O[C@H]([C@H]3c9ccccc9)c%10ccccc%10 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 F20 compound treatment 167260.0 -214000.0 -1.07 144520.0 -180000.0 -0.85 -1.3577 -0.9934 2142045 PK04_097116 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(OCCO)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N)c7cc(C#CCCO)ccc17 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 F21 compound treatment 321770.0 -60000.0 -0.3 236560.0 -88400.0 -0.42 -0.5059 -0.987 2141938 PK04_097117 Oc1ccc(cc1)[C@H]2N3[C@@H]([C@@H](C(=O)N4CCN(CC4)c5ncccn5)[C@]26C(=O)Nc7ccccc76)C(=O)O[C@@H]([C@@H]3c8ccccc8)c9ccccc9 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 F22 compound treatment 248020.0 -134000.0 -0.67 212020.0 -113000.0 -0.53 -0.848 -0.9936 2144373 PK04_097118 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(O)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCN(CC7)c8ncccn8)c9cc(C#CC%10(O)CCCCCC%10)ccc19 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 F23 compound treatment 204840.0 -177000.0 -0.88 199430.0 -126000.0 -0.59 -1.0423 -0.9808 2141419 PK04_097119 COc1ccc(C#Cc2ccc3NC(=O)[C@@]4([C@H]([C@H]5N([C@H]4c6ccc(O)cc6)[C@@H]([C@@H](OC5=O)c7ccccc7)c8ccccc8)C(=O)N)c3c2)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 F24 compound treatment 351750.0 -30000.0 -0.15 203130.0 -122000.0 -0.57 -0.5112 -0.8629 2142769 PK04_097120 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccccc4OCCO)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)Nc7nc8ccccc8s7)c9cc(C#CC%10(O)CCCCCC%10)ccc19 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 G01 compound treatment 436990.0 55300.0 0.28 419740.0 94800.0 0.45 0.5103 0.9734 2141178 PK04_097121 OCCOc1ccc(cc1)[C@@H]2N3[C@H]([C@H](C(=O)Nc4nc5ccccc5s4)[C@@]26C(=O)Nc7ccc(C#CCCO)cc76)C(=O)O[C@H]([C@H]3c8ccccc8)c9ccccc9 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 G02 compound treatment 232650.0 -149000.0 -0.74 168800.0 -156000.0 -0.73 -1.046 -1.0 2141487 PK04_097122 Oc1ccc(cc1)[C@@H]2N3[C@H]([C@H](C(=O)N4CCN(CC4)c5ncccn5)[C@@]26C(=O)Nc7ccc(C#CC8=CCCCC8)cc76)C(=O)O[C@H]([C@H]3c9ccccc9)c%10ccccc%10 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 G03 mock treatment 517250.0 136000.0 0.68 466160.0 141000.0 0.66 0.9481 1.0 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 G04 mock treatment 528420.0 147000.0 0.73 248540.0 -76400.0 -0.36 0.2638 0.3232 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 G05 compound treatment 486320.0 105000.0 0.52 180030.0 -145000.0 -0.68 -0.1128 -0.1313 2141519 PK04_097123 NC(=O)NCC#Cc1ccc2NC(=O)[C@]3([C@@H]([C@@H]4N([C@@H]3c5ccc(OCCO)cc5)[C@H]([C@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)Nc8nc9ccccc9s8)c2c1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 G06 compound treatment 450050.0 68300.0 0.34 220200.0 -105000.0 -0.49 -0.1072 -0.1789 2141537 PK04_097124 COC(=O)C(CC#Cc1ccc2NC(=O)[C@]3([C@@H]([C@@H]4N([C@@H]3c5ccc(OCCO)cc5)[C@H]([C@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)N8CCCCCCC8)c2c1)C(=O)OC 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 G07 compound treatment 192490.0 -189000.0 -0.95 203880.0 -121000.0 -0.57 -1.0711 -0.9706 2141722 PK04_097125 OCCOc1ccccc1[C@H]2N3[C@@H]([C@@H](C(=O)NCC=C)[C@]24C(=O)Nc5ccc(C#CC6(O)CCCCCC6)cc54)C(=O)O[C@@H]([C@@H]3c7ccccc7)c8ccccc8 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 G08 compound treatment 182980.0 -199000.0 -0.99 159770.0 -165000.0 -0.78 -1.2514 -0.9927 2141577 PK04_097126 COc1cc2CCN(Cc2cc1OC)C(=O)[C@@H]3[C@@H]4N([C@H](c5ccc(OCCO)cc5)[C@@]36C(=O)Nc7ccc(C#CC8=CCCCC8)cc76)[C@H]([C@H](OC4=O)c9ccccc9)c%10ccccc%10 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 G09 compound treatment 439610.0 57900.0 0.29 235850.0 -89100.0 -0.42 -0.0921 -0.1808 2141458 PK04_097127 Oc1ccc(cc1)[C@@H]2N3[C@H]([C@H](C(=O)NCC=C)[C@@]24C(=O)Nc5ccc(C#CC6(O)CCCCCC6)cc54)C(=O)O[C@H]([C@H]3c7ccccc7)c8ccccc8 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 G10 compound treatment 258820.0 -123000.0 -0.61 247130.0 -77900.0 -0.37 -0.693 -0.9695 2141190 PK04_097128 COC(=O)C(CC#Cc1ccc2NC(=O)[C@@]3([C@H]([C@H]4N([C@H]3c5ccc(OCCO)cc5)[C@@H]([C@@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)N8CCN(CC8)c9ncccn9)c2c1)C(=O)OC 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 G11 compound treatment 325370.0 -56400.0 -0.28 356170.0 31200.0 0.15 -0.0953 -0.3004 2141333 PK04_097129 COc1ccc(C#Cc2ccc3NC(=O)[C@@]4([C@H]([C@H]5N([C@H]4c6ccccc6OCCO)[C@@H]([C@@H](OC5=O)c7ccccc7)c8ccccc8)C(=O)N9CCN(CC9)c%10ncccn%10)c3c2)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 G12 compound treatment 135220.0 -247000.0 -1.23 227530.0 -97500.0 -0.46 -1.1947 -0.9094 2141508 PK04_097130 COc1ccc(C#Cc2ccc3NC(=O)[C@]4([C@@H]([C@@H]5N([C@@H]4c6ccc(OCCO)cc6)[C@H]([C@H](OC5=O)c7ccccc7)c8ccccc8)C(=O)Nc9nc%10ccccc%10s9)c3c2)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 G13 compound treatment 205240.0 -176000.0 -0.88 354720.0 29700.0 0.14 -0.5244 -0.5876 2141118 PK04_097131 COC(=O)C(CC#Cc1ccc2NC(=O)[C@@]3([C@H]([C@H]4N([C@H]3c5ccc(O)cc5)[C@@H]([C@@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)O)c2c1)C(=O)OC 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 G14 compound treatment 152410.0 -229000.0 -1.15 240710.0 -84300.0 -0.4 -1.0902 -0.8995 2141927 PK04_097132 OCCOc1ccccc1[C@H]2N3[C@@H]([C@@H](C(=O)N4CCN(CC4)c5ncccn5)[C@]26C(=O)Nc7ccccc76)C(=O)O[C@@H]([C@@H]3c8ccccc8)c9ccccc9 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 G15 compound treatment 429730.0 48000.0 0.24 215950.0 -109000.0 -0.51 -0.1931 -0.3412 2141159 PK04_097133 COc1ccc(C#Cc2ccc3NC(=O)[C@@]4([C@H]([C@H]5N([C@H]4c6ccc(OCCO)cc6)[C@@H]([C@@H](OC5=O)c7ccccc7)c8ccccc8)C(=O)N9CCc%10cc(OC)c(OC)cc%10C9)c3c2)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 G16 compound treatment 191770.0 -190000.0 -0.95 329840.0 4850.0 0.02 -0.6547 -0.6899 2141713 PK04_097134 COC(=O)C(CC#Cc1ccc2NC(=O)[C@]3([C@@H]([C@@H]4N([C@@H]3c5ccccc5OCCO)[C@H]([C@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)N8CCCCCCC8)c2c1)C(=O)OC 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 G17 compound treatment 179430.0 -202000.0 -1.01 235790.0 -89200.0 -0.42 -1.0111 -0.9242 2141795 PK04_097135 OCCC#Cc1ccc2NC(=O)[C@]3([C@@H]([C@@H]4N([C@@H]3c5ccc(O)cc5)[C@H]([C@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)N8CCN(CC8)c9ncccn9)c2c1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 G18 compound treatment 263840.0 -118000.0 -0.59 191240.0 -134000.0 -0.63 -0.8612 -0.9995 2141553 PK04_097136 OCCOc1ccc(cc1)[C@H]2N3[C@@H]([C@@H](C(=O)N4CCN(CC4)c5ncccn5)[C@]26C(=O)Nc7ccc(C#CC8(O)CCCCCC8)cc76)C(=O)O[C@@H]([C@@H]3c9ccccc9)c%10ccccc%10 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 G19 mock treatment 258050.0 -124000.0 -0.62 175230.0 -150000.0 -0.7 -0.9349 -0.9979 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 G20 mock treatment 311360.0 -70400.0 -0.35 245600.0 -79400.0 -0.37 -0.5126 -0.9995 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 G21 compound treatment 225440.0 -156000.0 -0.78 392690.0 67700.0 0.32 -0.3268 -0.3876 2141819 PK04_097137 COc1cc2CCN(Cc2cc1OC)C(=O)[C@@H]3[C@@H]4N([C@H](c5ccc(O)cc5)[C@@]36C(=O)Nc7ccc(C#CC8(O)CCCCCC8)cc76)[C@H]([C@H](OC4=O)c9ccccc9)c%10ccccc%10 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 G22 compound treatment 157020.0 -225000.0 -1.12 369370.0 44400.0 0.21 -0.646 -0.5659 2141516 PK04_097138 NC(=O)NCC#Cc1ccc2NC(=O)[C@]3([C@@H]([C@@H]4N([C@@H]3c5ccc(OCCO)cc5)[C@H]([C@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)NC[C@H](O)c8ccccc8)c2c1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 G23 compound treatment 278720.0 -103000.0 -0.51 231940.0 -93000.0 -0.44 -0.6733 -0.9968 2141691 PK04_097139 NC(=O)NCC#Cc1ccc2NC(=O)[C@]3([C@@H]([C@@H]4N([C@@H]3c5ccccc5OCCO)[C@H]([C@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)N8CCCCCCC8)c2c1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 G24 compound treatment 153990.0 -228000.0 -1.14 157470.0 -168000.0 -0.79 -1.3615 -0.9839 2141155 PK04_097140 COc1ccc(C#Cc2ccc3NC(=O)[C@@]4([C@H]([C@H]5N([C@H]4c6ccc(OCCO)cc6)[C@@H]([C@@H](OC5=O)c7ccccc7)c8ccccc8)C(=O)N)c3c2)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 H01 compound treatment 339230.0 -42500.0 -0.21 206760.0 -118000.0 -0.56 -0.5433 -0.9128 2141157 PK04_097141 COc1ccc(C#Cc2ccc3NC(=O)[C@@]4([C@H]([C@H]5N([C@H]4c6ccc(OCCO)cc6)[C@@H]([C@@H](OC5=O)c7ccccc7)c8ccccc8)C(=O)N9CCN(CC9)c%10ncccn%10)c3c2)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 H02 compound treatment 503410.0 122000.0 0.61 475970.0 151000.0 0.71 0.9319 0.997 2143037 PK04_097142 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(O)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NC[C@H](O)c7ccccc7)c8cc(C#CCC(C(=O)OC)C(=O)OC)ccc18 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 H03 mock treatment 526400.0 145000.0 0.72 168840.0 -156000.0 -0.73 -0.0084 -0.0082 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 H04 mock treatment 479410.0 97700.0 0.49 185120.0 -140000.0 -0.66 -0.1202 -0.1468 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 H05 compound treatment 179380.0 -202000.0 -1.01 124820.0 -200000.0 -0.94 -1.3804 -0.9994 2141926 PK04_097143 OCCOc1ccccc1[C@H]2N3[C@@H]([C@@H](C(=O)Nc4nc5ccccc5s4)[C@]26C(=O)Nc7ccccc76)C(=O)O[C@@H]([C@@H]3c8ccccc8)c9ccccc9 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 H06 compound treatment 279460.0 -102000.0 -0.51 450650.0 126000.0 0.59 0.0568 0.0727 2143177 PK04_097144 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(O)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCc8cc(OC)c(OC)cc8C7)c9cc(C#CC%10=CCCCC%10)ccc19 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 H07 compound treatment 228270.0 -153000.0 -0.77 161220.0 -164000.0 -0.77 -1.0867 -1.0 2141694 PK04_097145 NC(=O)NCC#Cc1ccc2NC(=O)[C@]3([C@@H]([C@@H]4N([C@@H]3c5ccccc5OCCO)[C@H]([C@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)N)c2c1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 H08 compound treatment 380960.0 -773.0 0.0 186640.0 -138000.0 -0.65 -0.4629 -0.7113 2143025 PK04_097146 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(O)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NCC=C)c7cc(C#CCC(C(=O)OC)C(=O)OC)ccc17 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 H09 compound treatment 124330.0 -257000.0 -1.29 174080.0 -151000.0 -0.71 -1.411 -0.9608 2141749 PK04_097147 NC(=O)[C@@H]1[C@@H]2N([C@H](c3ccccc3OCCO)[C@@]14C(=O)Nc5ccc(C#CC6=CCCCC6)cc54)[C@H]([C@H](OC2=O)c7ccccc7)c8ccccc8 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 H10 compound treatment 173790.0 -208000.0 -1.04 248080.0 -76900.0 -0.36 -0.9902 -0.9003 2143077 PK04_097148 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(O)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NC[C@H](O)c7ccccc7)c8cc(C#CC9(O)CCCCCC9)ccc18 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 H11 compound treatment 103710.0 -278000.0 -1.39 166560.0 -158000.0 -0.75 -1.5088 -0.9574 2141097 PK04_097149 OCCOc1ccc(cc1)[C@@H]2N3[C@H]([C@H](C(=O)O)[C@@]24C(=O)Nc5ccc(C#CC6=CCCCC6)cc54)C(=O)O[C@H]([C@H]3c7ccccc7)c8ccccc8 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 H12 compound treatment 259360.0 -122000.0 -0.61 192660.0 -132000.0 -0.62 -0.8723 -1.0 2142913 PK04_097150 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(O)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCCCCCC7)c8cc(C#Cc9ccc(OC)cc9)ccc18 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 H13 compound treatment 191880.0 -190000.0 -0.95 206210.0 -119000.0 -0.56 -1.0655 -0.9682 2141401 PK04_097151 COc1cc2CCN(Cc2cc1OC)C(=O)[C@H]3[C@H]4N([C@@H](c5ccccc5OCCO)[C@]36C(=O)Nc7ccc(C#CC8=CCCCC8)cc76)[C@@H]([C@@H](OC4=O)c9ccccc9)c%10ccccc%10 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 H14 compound treatment 243240.0 -138000.0 -0.69 332080.0 7090.0 0.03 -0.4655 -0.6722 2143093 PK04_097152 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(O)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCN(CC7)c8ncccn8)c9cc(C#CC%10(O)CCCCCC%10)ccc19 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 H15 compound treatment 308040.0 -73700.0 -0.37 420680.0 95700.0 0.45 0.058 0.0998 2141777 PK04_097153 NC(=O)NCC#Cc1ccc2NC(=O)[C@]3([C@@H]([C@@H]4N([C@@H]3c5ccc(O)cc5)[C@H]([C@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)NCC=C)c2c1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 H16 compound treatment 225280.0 -156000.0 -0.78 157480.0 -168000.0 -0.79 -1.1097 -1.0 2143865 PK04_097154 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccccc4OCCO)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NCC=C)c7cc(C#Cc8ccc(OC)cc8)ccc17 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 H17 compound treatment 454160.0 72400.0 0.36 241770.0 -83200.0 -0.39 -0.021 -0.0394 2141142 PK04_097155 NC(=O)NCC#Cc1ccc2NC(=O)[C@]3([C@@H]([C@@H]4N([C@@H]3c5ccc(O)cc5)[C@H]([C@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)O)c2c1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 H18 compound treatment 269670.0 -112000.0 -0.56 380800.0 55800.0 0.26 -0.2101 -0.3399 2143925 PK04_097156 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccccc4OCCO)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N)c7cc(C#CCNC(=O)N)ccc17 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 H19 mock treatment 222510.0 -159000.0 -0.8 266660.0 -58300.0 -0.27 -0.7563 -0.8991 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 H20 mock treatment 396160.0 14400.0 0.07 209020.0 -116000.0 -0.55 -0.3348 -0.6084 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 H21 compound treatment 285830.0 -95900.0 -0.48 279470.0 -45500.0 -0.21 -0.4901 -0.9341 2141168 PK04_097157 NC(=O)NCC#Cc1ccc2NC(=O)[C@@]3([C@H]([C@H]4N([C@H]3c5ccc(OCCO)cc5)[C@@H]([C@@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)N8CCN(CC8)c9ncccn9)c2c1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 H22 compound treatment 395840.0 14100.0 0.07 275090.0 -49900.0 -0.23 -0.1161 -0.4739 2143057 PK04_097158 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(O)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCc8cc(OC)c(OC)cc8C7)c9cc(C#CCC(C(=O)OC)C(=O)OC)ccc19 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 H23 compound treatment 471420.0 89700.0 0.45 373610.0 48600.0 0.23 0.4785 0.9513 2141804 PK04_097159 COC(=O)C(CC#Cc1ccc2NC(=O)[C@]3([C@@H]([C@@H]4N([C@@H]3c5ccc(O)cc5)[C@H]([C@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)N)c2c1)C(=O)OC 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 H24 compound treatment 488220.0 106000.0 0.53 286450.0 -38500.0 -0.18 0.2479 0.4412 2142649 PK04_097160 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccccc4OCCO)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)Nc7nc8ccccc8s7)c9cc(C#CCNC(=O)N)ccc19 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 I01 compound treatment 470610.0 88900.0 0.44 251200.0 -73800.0 -0.35 0.0685 0.1215 2141890 PK04_097161 O[C@@H](CNC(=O)[C@H]1[C@H]2N([C@@H](c3ccc(O)cc3)[C@]14C(=O)Nc5ccccc54)[C@@H]([C@@H](OC2=O)c6ccccc6)c7ccccc7)c8ccccc8 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 I02 compound treatment 449010.0 67300.0 0.34 271090.0 -53900.0 -0.25 0.0583 0.1386 2141465 PK04_097162 Oc1ccc(cc1)[C@@H]2N3[C@H]([C@H](C(=O)N4CCN(CC4)c5ncccn5)[C@@]26C(=O)Nc7ccc(C#CC8(O)CCCCCC8)cc76)C(=O)O[C@H]([C@H]3c9ccccc9)c%10ccccc%10 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 I03 compound treatment 486770.0 105000.0 0.52 153090.0 -172000.0 -0.81 -0.2008 -0.2083 2141772 PK04_097163 COc1ccc(C#Cc2ccc3NC(=O)[C@]4([C@@H]([C@@H]5N([C@@H]4c6ccc(O)cc6)[C@H]([C@H](OC5=O)c7ccccc7)c8ccccc8)C(=O)Nc9nc%10ccccc%10s9)c3c2)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 I04 compound treatment 210920.0 -171000.0 -0.85 443250.0 118000.0 0.56 -0.2099 -0.2061 2141343 PK04_097164 NC(=O)NCC#Cc1ccc2NC(=O)[C@@]3([C@H]([C@H]4N([C@H]3c5ccccc5OCCO)[C@@H]([C@@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)Nc8nc9ccccc9s8)c2c1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 I05 mock treatment 380920.0 -813.0 0.0 224800.0 -100000.0 -0.47 -0.3361 -0.7132 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 I06 mock treatment 332230.0 -49500.0 -0.25 448030.0 123000.0 0.58 0.2344 0.3725 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 I07 compound treatment 284810.0 -96900.0 -0.48 103400.0 -222000.0 -1.04 -1.0793 -0.9392 2141794 PK04_097165 OCCC#Cc1ccc2NC(=O)[C@]3([C@@H]([C@@H]4N([C@@H]3c5ccc(O)cc5)[C@H]([C@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)Nc8nc9ccccc9s8)c2c1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 I08 compound treatment 165190.0 -217000.0 -1.08 385820.0 60800.0 0.29 -0.5624 -0.5027 2141922 PK04_097166 OCCOc1ccccc1[C@H]2N3[C@@H]([C@@H](C(=O)N4CCCCCCC4)[C@]25C(=O)Nc6ccccc65)C(=O)O[C@@H]([C@@H]3c7ccccc7)c8ccccc8 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 I09 compound treatment 240810.0 -141000.0 -0.7 149300.0 -176000.0 -0.83 -1.082 -0.9968 2141780 PK04_097167 NC(=O)NCC#Cc1ccc2NC(=O)[C@]3([C@@H]([C@@H]4N([C@@H]3c5ccc(O)cc5)[C@H]([C@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)NC[C@H](O)c8ccccc8)c2c1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 I10 compound treatment 171040.0 -211000.0 -1.05 485950.0 161000.0 0.76 -0.2087 -0.161 2141799 PK04_097168 COC(=O)C(CC#Cc1ccc2NC(=O)[C@]3([C@@H]([C@@H]4N([C@@H]3c5ccc(O)cc5)[C@H]([C@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)NCC=C)c2c1)C(=O)OC 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 I11 compound treatment 161280.0 -220000.0 -1.1 135230.0 -190000.0 -0.89 -1.4097 -0.9946 2141177 PK04_097169 NC(=O)[C@H]1[C@H]2N([C@@H](c3ccc(OCCO)cc3)[C@]14C(=O)Nc5ccc(C#CCCO)cc54)[C@@H]([C@@H](OC2=O)c6ccccc6)c7ccccc7 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 I12 compound treatment 109170.0 -273000.0 -1.36 126240.0 -199000.0 -0.93 -1.6236 -0.9832 2141747 PK04_097170 OCCOc1ccccc1[C@H]2N3[C@@H]([C@@H](C(=O)NC[C@H](O)c4ccccc4)[C@]25C(=O)Nc6ccc(C#CC7=CCCCC7)cc65)C(=O)O[C@@H]([C@@H]3c8ccccc8)c9ccccc9 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 I13 compound treatment 293500.0 -88200.0 -0.44 218130.0 -107000.0 -0.5 -0.667 -0.9979 2141423 PK04_097171 COc1ccc(C#Cc2ccc3NC(=O)[C@@]4([C@H]([C@H]5N([C@H]4c6ccc(O)cc6)[C@@H]([C@@H](OC5=O)c7ccccc7)c8ccccc8)C(=O)N9CCc%10cc(OC)c(OC)cc%10C9)c3c2)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 I14 compound treatment 336880.0 -44900.0 -0.22 334100.0 9110.0 0.04 -0.1281 -0.5616 2141775 PK04_097172 COc1ccc(C#Cc2ccc3NC(=O)[C@]4([C@@H]([C@@H]5N([C@@H]4c6ccc(O)cc6)[C@H]([C@H](OC5=O)c7ccccc7)c8ccccc8)C(=O)N9CCc%10cc(OC)c(OC)cc%10C9)c3c2)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 I15 compound treatment 398410.0 16700.0 0.08 330040.0 5050.0 0.02 0.0757 0.874 2141538 PK04_097173 COC(=O)C(CC#Cc1ccc2NC(=O)[C@]3([C@@H]([C@@H]4N([C@@H]3c5ccc(OCCO)cc5)[C@H]([C@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)NC[C@H](O)c8ccccc8)c2c1)C(=O)OC 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 I16 compound treatment 213460.0 -168000.0 -0.84 232160.0 -92800.0 -0.44 -0.903 -0.9535 2065871 PK04_097174 OCCOc1ccc(cc1)[C@H]2N3[C@@H]([C@@H](C(=O)O)[C@]24C(=O)Nc5ccc(C#CC6(O)CCCCCC6)cc54)C(=O)O[C@@H]([C@@H]3c7ccccc7)c8ccccc8 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 I17 compound treatment 182010.0 -200000.0 -1.0 312610.0 -12400.0 -0.06 -0.7465 -0.7471 2141729 PK04_097175 OCCOc1ccccc1[C@H]2N3[C@@H]([C@@H](C(=O)N4CCN(CC4)c5ncccn5)[C@]26C(=O)Nc7ccc(C#CC8(O)CCCCCC8)cc76)C(=O)O[C@@H]([C@@H]3c9ccccc9)c%10ccccc%10 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 I18 compound treatment 456860.0 75100.0 0.38 284190.0 -40800.0 -0.19 0.1296 0.3076 2141892 PK04_097176 NC(=O)[C@H]1[C@H]2N([C@@H](c3ccc(O)cc3)[C@]14C(=O)Nc5ccccc54)[C@@H]([C@@H](OC2=O)c6ccccc6)c7ccccc7 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 I19 compound treatment 446810.0 65100.0 0.33 258080.0 -66900.0 -0.31 0.0073 0.0161 2141687 PK04_097177 COc1ccc(C#Cc2ccc3NC(=O)[C@]4([C@@H]([C@@H]5N([C@@H]4c6ccccc6OCCO)[C@H]([C@H](OC5=O)c7ccccc7)c8ccccc8)C(=O)N9CCc%10cc(OC)c(OC)cc%10C9)c3c2)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 I20 compound treatment 285710.0 -96000.0 -0.48 255680.0 -69300.0 -0.33 -0.5696 -0.9823 2141680 PK04_097178 COc1ccc(C#Cc2ccc3NC(=O)[C@]4([C@@H]([C@@H]5N([C@@H]4c6ccccc6OCCO)[C@H]([C@H](OC5=O)c7ccccc7)c8ccccc8)C(=O)N9CCCCCCC9)c3c2)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 I21 mock treatment 201070.0 -181000.0 -0.9 223610.0 -101000.0 -0.48 -0.9752 -0.9556 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 I22 mock treatment 280720.0 -101000.0 -0.5 214480.0 -111000.0 -0.52 -0.7243 -0.9999 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 I23 compound treatment 275740.0 -106000.0 -0.53 296560.0 -28400.0 -0.13 -0.4689 -0.8587 2141841 PK04_097179 COc1cc2CCN(Cc2cc1OC)C(=O)[C@@H]3[C@@H]4N([C@H](c5ccc(O)cc5)[C@@]36C(=O)Nc7ccc(C#CC8=CCCCC8)cc76)[C@H]([C@H](OC4=O)c9ccccc9)c%10ccccc%10 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 I24 compound treatment 458990.0 77300.0 0.39 226370.0 -98600.0 -0.46 -0.0552 -0.0914 2141766 PK04_097180 COc1ccc(C#Cc2ccc3NC(=O)[C@]4([C@@H]([C@@H]5N([C@@H]4c6ccc(O)cc6)[C@H]([C@H](OC5=O)c7ccccc7)c8ccccc8)C(=O)NCC=C)c3c2)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 J01 compound treatment 344320.0 -37400.0 -0.19 167150.0 -158000.0 -0.74 -0.6571 -0.8583 2141705 PK04_097181 NC(=O)[C@@H]1[C@@H]2N([C@H](c3ccccc3OCCO)[C@@]14C(=O)Nc5ccc(C#CCCO)cc54)[C@H]([C@H](OC2=O)c6ccccc6)c7ccccc7 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 J02 compound treatment 276320.0 -105000.0 -0.53 308920.0 -16100.0 -0.08 -0.4257 -0.8004 2143397 PK04_097182 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(OCCO)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NC[C@H](O)c7ccccc7)c8cc(C#CC9(O)CCCCCC9)ccc18 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 J03 compound treatment 493470.0 112000.0 0.56 414920.0 89900.0 0.42 0.6937 0.9907 2141179 PK04_097183 OCCOc1ccc(cc1)[C@@H]2N3[C@H]([C@H](C(=O)N4CCN(CC4)c5ncccn5)[C@@]26C(=O)Nc7ccc(C#CCCO)cc76)C(=O)O[C@H]([C@H]3c8ccccc8)c9ccccc9 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 J04 compound treatment 526750.0 145000.0 0.72 493710.0 169000.0 0.79 1.0733 0.999 2144337 PK04_097184 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(O)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCc8cc(OC)c(OC)cc8C7)c9cc(C#CCC(C(=O)OC)C(=O)OC)ccc19 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 J05 mock treatment 472510.0 90800.0 0.45 179380.0 -146000.0 -0.68 -0.1637 -0.1993 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 J06 mock treatment 507000.0 125000.0 0.63 420640.0 95700.0 0.45 0.7605 0.9869 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 J07 compound treatment 483680.0 102000.0 0.51 156110.0 -169000.0 -0.79 -0.2016 -0.2137 2141805 PK04_097185 COC(=O)C(CC#Cc1ccc2NC(=O)[C@]3([C@@H]([C@@H]4N([C@@H]3c5ccc(O)cc5)[C@H]([C@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)Nc8nc9ccccc9s8)c2c1)C(=O)OC 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 J08 compound treatment 162560.0 -219000.0 -1.09 221160.0 -104000.0 -0.49 -1.1194 -0.9339 2143365 PK04_097186 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(OCCO)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N)c7cc(C#CCC(C(=O)OC)C(=O)OC)ccc17 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 J09 compound treatment 180000.0 -202000.0 -1.01 112070.0 -213000.0 -1.0 -1.4206 -1.0 2141901 PK04_097187 OCCOc1ccc(cc1)[C@H]2N3[C@@H]([C@@H](C(=O)NC[C@H](O)c4ccccc4)[C@]25C(=O)Nc6ccccc65)C(=O)O[C@@H]([C@@H]3c7ccccc7)c8ccccc8 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 J10 compound treatment 214460.0 -167000.0 -0.84 138920.0 -186000.0 -0.88 -1.2096 -0.9997 2144881 PK04_097188 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccccc4OCCO)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCCCCCC7)c8ccccc18 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 J11 compound treatment 170840.0 -211000.0 -1.05 122090.0 -203000.0 -0.95 -1.4196 -0.9988 2141717 PK04_097189 COC(=O)C(CC#Cc1ccc2NC(=O)[C@]3([C@@H]([C@@H]4N([C@@H]3c5ccccc5OCCO)[C@H]([C@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)Nc8nc9ccccc9s8)c2c1)C(=O)OC 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 J12 compound treatment 309150.0 -72600.0 -0.36 127150.0 -198000.0 -0.93 -0.9143 -0.9156 2143405 PK04_097190 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(OCCO)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N)c7cc(C#CC8(O)CCCCCC8)ccc17 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 J13 compound treatment 483040.0 101000.0 0.51 383240.0 58300.0 0.27 0.5515 0.9585 2141188 PK04_097191 COC(=O)C(CC#Cc1ccc2NC(=O)[C@@]3([C@H]([C@H]4N([C@H]3c5ccc(OCCO)cc5)[C@@H]([C@@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)N)c2c1)C(=O)OC 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 J14 compound treatment 232170.0 -150000.0 -0.75 290320.0 -34700.0 -0.16 -0.6435 -0.8416 2142929 PK04_097192 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(O)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)Nc7nc8ccccc8s7)c9cc(C#Cc%10ccc(OC)cc%10)ccc19 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 J15 compound treatment 462010.0 80300.0 0.4 254240.0 -70700.0 -0.33 0.0482 0.0925 2141365 PK04_097193 COC(=O)C(CC#Cc1ccc2NC(=O)[C@@]3([C@H]([C@H]4N([C@H]3c5ccccc5OCCO)[C@@H]([C@@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)Nc8nc9ccccc9s8)c2c1)C(=O)OC 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 J16 compound treatment 464410.0 82700.0 0.41 247700.0 -77300.0 -0.36 0.0349 0.0635 2144325 PK04_097194 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(O)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N)c7cc(C#CCC(C(=O)OC)C(=O)OC)ccc17 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 J17 compound treatment 210410.0 -171000.0 -0.86 154300.0 -171000.0 -0.8 -1.1728 -0.9995 2141221 PK04_097195 NC(=O)[C@H]1[C@H]2N([C@@H](c3ccc(OCCO)cc3)[C@]14C(=O)Nc5ccc(C#CC6=CCCCC6)cc54)[C@@H]([C@@H](OC2=O)c7ccccc7)c8ccccc8 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 J18 compound treatment 398560.0 16800.0 0.08 386260.0 61300.0 0.29 0.2632 0.8768 2143377 PK04_097196 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(OCCO)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCc8cc(OC)c(OC)cc8C7)c9cc(C#CCC(C(=O)OC)C(=O)OC)ccc19 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 J19 compound treatment 344080.0 -37700.0 -0.19 233560.0 -91400.0 -0.43 -0.4371 -0.9312 2141815 PK04_097197 NC(=O)[C@@H]1[C@@H]2N([C@H](c3ccc(O)cc3)[C@@]14C(=O)Nc5ccc(C#CC6(O)CCCCCC6)cc54)[C@H]([C@H](OC2=O)c7ccccc7)c8ccccc8 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 J20 compound treatment 280740.0 -101000.0 -0.5 163530.0 -161000.0 -0.76 -0.8937 -0.9802 2142585 PK04_097198 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccccc4OCCO)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NCC=C)c7cc(C#Cc8ccc(OC)cc8)ccc17 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 J21 mock treatment 284960.0 -96800.0 -0.48 431600.0 107000.0 0.5 0.0128 0.0184 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 J22 mock treatment 472340.0 90600.0 0.45 370250.0 45300.0 0.21 0.4705 0.9409 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 J23 compound treatment 287140.0 -94600.0 -0.47 332650.0 7660.0 0.04 -0.3086 -0.6513 2141186 PK04_097199 COC(=O)C(CC#Cc1ccc2NC(=O)[C@@]3([C@H]([C@H]4N([C@H]3c5ccc(OCCO)cc5)[C@@H]([C@@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)NC[C@H](O)c8ccccc8)c2c1)C(=O)OC 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 J24 compound treatment 228510.0 -153000.0 -0.77 382570.0 57600.0 0.27 -0.3496 -0.4307 2144237 PK04_097200 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(O)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NC[C@H](O)c7ccccc7)c8cc(C#CCNC(=O)N)ccc18 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 K01 compound treatment 261240.0 -120000.0 -0.6 436500.0 112000.0 0.52 -0.0546 -0.0685 2141164 PK04_097201 NC(=O)NCC#Cc1ccc2NC(=O)[C@@]3([C@H]([C@H]4N([C@H]3c5ccc(OCCO)cc5)[C@@H]([C@@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)NC[C@H](O)c8ccccc8)c2c1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 K02 compound treatment 502170.0 120000.0 0.6 501190.0 176000.0 0.83 1.0114 0.9876 2141443 PK04_097202 OCCC#Cc1ccc2NC(=O)[C@@]3([C@H]([C@H]4N([C@H]3c5ccc(O)cc5)[C@@H]([C@@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)N8CCN(CC8)c9ncccn9)c2c1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 K03 compound treatment 414040.0 32300.0 0.16 156370.0 -169000.0 -0.79 -0.4467 -0.5519 2141548 PK04_097203 OCCOc1ccc(cc1)[C@H]2N3[C@@H]([C@@H](C(=O)N4CCCCCCC4)[C@]25C(=O)Nc6ccc(C#CC7(O)CCCCCC7)cc65)C(=O)O[C@@H]([C@@H]3c8ccccc8)c9ccccc9 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 K04 compound treatment 206200.0 -176000.0 -0.88 444640.0 120000.0 0.56 -0.222 -0.2131 2141351 PK04_097204 OCCOc1ccccc1[C@@H]2N3[C@H]([C@H](C(=O)NC[C@H](O)c4ccccc4)[C@@]25C(=O)Nc6ccc(C#CCCO)cc65)C(=O)O[C@H]([C@H]3c7ccccc7)c8ccccc8 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 K05 compound treatment 526410.0 145000.0 0.72 139430.0 -186000.0 -0.87 -0.1062 -0.0937 2141786 PK04_097205 COc1cc2CCN(Cc2cc1OC)C(=O)[C@@H]3[C@@H]4N([C@H](c5ccc(O)cc5)[C@@]36C(=O)Nc7ccc(C#CCNC(=O)N)cc76)[C@H]([C@H](OC4=O)c8ccccc8)c9ccccc9 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 K06 compound treatment 314200.0 -67500.0 -0.34 148610.0 -176000.0 -0.83 -0.8251 -0.9214 2141746 PK04_097206 OCCOc1ccccc1[C@H]2N3[C@@H]([C@@H](C(=O)N4CCCCCCC4)[C@]25C(=O)Nc6ccc(C#CC7=CCCCC7)cc65)C(=O)O[C@@H]([C@@H]3c8ccccc8)c9ccccc9 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 K07 mock treatment 218010.0 -164000.0 -0.82 482670.0 158000.0 0.74 -0.0538 -0.0487 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 K08 mock treatment 502090.0 120000.0 0.6 501460.0 176000.0 0.83 1.012 0.9874 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 K09 compound treatment 146630.0 -235000.0 -1.17 95140.0 -230000.0 -1.08 -1.5948 -0.9991 2141350 PK04_097207 OCCOc1ccccc1[C@@H]2N3[C@H]([C@H](C(=O)N4CCCCCCC4)[C@@]25C(=O)Nc6ccc(C#CCCO)cc65)C(=O)O[C@H]([C@H]3c7ccccc7)c8ccccc8 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 K10 compound treatment 125830.0 -256000.0 -1.28 113560.0 -211000.0 -0.99 -1.607 -0.9923 2141331 PK04_097208 COc1ccc(C#Cc2ccc3NC(=O)[C@@]4([C@H]([C@H]5N([C@H]4c6ccccc6OCCO)[C@@H]([C@@H](OC5=O)c7ccccc7)c8ccccc8)C(=O)N)c3c2)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 K11 compound treatment 498120.0 116000.0 0.58 151130.0 -174000.0 -0.82 -0.1672 -0.1667 2141806 PK04_097209 COC(=O)C(CC#Cc1ccc2NC(=O)[C@]3([C@@H]([C@@H]4N([C@@H]3c5ccc(O)cc5)[C@H]([C@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)N8CCN(CC8)c9ncccn9)c2c1)C(=O)OC 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 K12 compound treatment 325940.0 -55800.0 -0.28 425460.0 100000.0 0.47 0.1371 0.25 2141720 PK04_097210 COC(=O)C(CC#Cc1ccc2NC(=O)[C@]3([C@@H]([C@@H]4N([C@@H]3c5ccccc5OCCO)[C@H]([C@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)N8CCc9cc(OC)c(OC)cc9C8)c2c1)C(=O)OC 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 K13 compound treatment 341890.0 -39800.0 -0.2 158560.0 -166000.0 -0.78 -0.6942 -0.8595 2141904 PK04_097211 OCCOc1ccc(cc1)[C@H]2N3[C@@H]([C@@H](C(=O)Nc4nc5ccccc5s4)[C@]26C(=O)Nc7ccccc76)C(=O)O[C@@H]([C@@H]3c8ccccc8)c9ccccc9 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 K14 compound treatment 214910.0 -167000.0 -0.83 163170.0 -162000.0 -0.76 -1.1274 -0.999 2141222 PK04_097212 OCCOc1ccc(cc1)[C@@H]2N3[C@H]([C@H](C(=O)Nc4nc5ccccc5s4)[C@@]26C(=O)Nc7ccc(C#CC8=CCCCC8)cc76)C(=O)O[C@H]([C@H]3c9ccccc9)c%10ccccc%10 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 K15 mock treatment 457840.0 76100.0 0.38 516930.0 192000.0 0.9 0.9072 0.9261 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 K16 mock treatment 199870.0 -182000.0 -0.91 288840.0 -36100.0 -0.17 -0.7625 -0.8251 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 K17 compound treatment 393300.0 11600.0 0.06 289600.0 -35400.0 -0.17 -0.0768 -0.4362 2141773 PK04_097213 COc1ccc(C#Cc2ccc3NC(=O)[C@]4([C@@H]([C@@H]5N([C@@H]4c6ccc(O)cc6)[C@H]([C@H](OC5=O)c7ccccc7)c8ccccc8)C(=O)N9CCN(CC9)c%10ncccn%10)c3c2)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 K18 compound treatment 351070.0 -30700.0 -0.15 282400.0 -42600.0 -0.2 -0.2499 -0.9912 2141524 PK04_097214 OCCOc1ccc(cc1)[C@H]2N3[C@@H]([C@@H](C(=O)NCC=C)[C@]24C(=O)Nc5ccc(C#CCCO)cc54)C(=O)O[C@@H]([C@@H]3c6ccccc6)c7ccccc7 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 K19 compound treatment 253570.0 -128000.0 -0.64 266570.0 -58400.0 -0.27 -0.6469 -0.9287 2141218 PK04_097215 OCCOc1ccc(cc1)[C@@H]2N3[C@H]([C@H](C(=O)N4CCCCCCC4)[C@@]25C(=O)Nc6ccc(C#CC7=CCCCC7)cc65)C(=O)O[C@H]([C@H]3c8ccccc8)c9ccccc9 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 K20 compound treatment 294560.0 -87200.0 -0.44 202440.0 -123000.0 -0.58 -0.7155 -0.9904 2141861 PK04_097216 OCCOc1ccc(cc1)[C@@H]2N3[C@H]([C@H](C(=O)N4CCN(CC4)c5ncccn5)[C@@]26C(=O)Nc7ccccc76)C(=O)O[C@H]([C@H]3c8ccccc8)c9ccccc9 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 K21 compound treatment 422900.0 41200.0 0.21 259840.0 -65100.0 -0.31 -0.0713 -0.1932 2141117 PK04_097217 OCCC#Cc1ccc2NC(=O)[C@@]3([C@H]([C@H]4N([C@H]3c5ccc(O)cc5)[C@@H]([C@@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)O)c2c1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 K22 compound treatment 252570.0 -129000.0 -0.65 210460.0 -115000.0 -0.54 -0.8371 -0.996 2141354 PK04_097218 OCCOc1ccccc1[C@@H]2N3[C@H]([C@H](C(=O)Nc4nc5ccccc5s4)[C@@]26C(=O)Nc7ccc(C#CCCO)cc76)C(=O)O[C@H]([C@H]3c8ccccc8)c9ccccc9 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 K23 mock treatment 454270.0 72500.0 0.36 521450.0 196000.0 0.92 0.9096 0.9164 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 K24 mock treatment 505210.0 123000.0 0.62 424110.0 99100.0 0.47 0.7658 0.9905 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 L01 compound treatment 322560.0 -59200.0 -0.3 142130.0 -183000.0 -0.86 -0.8172 -0.8985 2141684 PK04_097219 COc1ccc(C#Cc2ccc3NC(=O)[C@]4([C@@H]([C@@H]5N([C@@H]4c6ccccc6OCCO)[C@H]([C@H](OC5=O)c7ccccc7)c8ccccc8)C(=O)Nc9nc%10ccccc%10s9)c3c2)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 L02 compound treatment 213330.0 -168000.0 -0.84 423760.0 98800.0 0.46 -0.2662 -0.2771 2143489 PK04_097220 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(OCCO)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)Nc7nc8ccccc8s7)c9cc(C#CC%10=CCCCC%10)ccc19 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 L03 compound treatment 100990.0 -281000.0 -1.4 86440.0 -239000.0 -1.12 -1.7849 -0.9939 2141375 PK04_097221 NC(=O)[C@H]1[C@H]2N([C@@H](c3ccccc3OCCO)[C@]14C(=O)Nc5ccc(C#CC6(O)CCCCCC6)cc54)[C@@H]([C@@H](OC2=O)c7ccccc7)c8ccccc8 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 L04 compound treatment 464830.0 83100.0 0.42 254510.0 -70500.0 -0.33 0.0591 0.1112 2143313 PK04_097222 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(OCCO)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCCCCCC7)c8cc(C#CCCO)ccc18 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 L05 compound treatment 180180.0 -202000.0 -1.01 118690.0 -206000.0 -0.97 -1.398 -0.9998 2141889 PK04_097223 Oc1ccc(cc1)[C@@H]2N3[C@H]([C@H](C(=O)N4CCCCCCC4)[C@@]25C(=O)Nc6ccccc65)C(=O)O[C@H]([C@H]3c7ccccc7)c8ccccc8 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 L06 compound treatment 423590.0 41900.0 0.21 362000.0 37000.0 0.17 0.2709 0.9959 2144793 PK04_097224 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(OCCO)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NCC=C)c7ccccc17 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 L07 mock treatment 422720.0 41000.0 0.2 436570.0 112000.0 0.52 0.5159 0.9157 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 L08 mock treatment 241280.0 -140000.0 -0.7 170160.0 -155000.0 -0.73 -1.011 -0.9998 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 L09 compound treatment 535330.0 154000.0 0.77 181620.0 -143000.0 -0.67 0.0656 0.0642 2141438 PK04_097225 OCCC#Cc1ccc2NC(=O)[C@@]3([C@H]([C@H]4N([C@H]3c5ccc(O)cc5)[C@@H]([C@@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)N8CCCCCCC8)c2c1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 L10 compound treatment 385640.0 3910.0 0.02 490030.0 165000.0 0.78 0.5627 0.7247 2142993 PK04_097226 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(O)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCCCCCC7)c8cc(C#CCCO)ccc18 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 L11 compound treatment 494570.0 113000.0 0.56 415050.0 90100.0 0.42 0.698 0.9901 2141185 PK04_097227 COC(=O)C(CC#Cc1ccc2NC(=O)[C@@]3([C@H]([C@H]4N([C@H]3c5ccc(OCCO)cc5)[C@@H]([C@@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)N8CCCCCCC8)c2c1)C(=O)OC 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 L12 compound treatment 167530.0 -214000.0 -1.07 408320.0 83300.0 0.39 -0.4793 -0.4207 2144653 PK04_097228 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(OCCO)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N)c7ccccc17 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 L13 compound treatment 145830.0 -236000.0 -1.18 255270.0 -69700.0 -0.33 -1.065 -0.8708 2141893 PK04_097229 Oc1ccc(cc1)[C@@H]2N3[C@H]([C@H](C(=O)Nc4nc5ccccc5s4)[C@@]26C(=O)Nc7ccccc76)C(=O)O[C@H]([C@H]3c8ccccc8)c9ccccc9 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 L14 compound treatment 307380.0 -74400.0 -0.37 251800.0 -73200.0 -0.34 -0.506 -0.9993 2143417 PK04_097230 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(OCCO)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCc8cc(OC)c(OC)cc8C7)c9cc(C#CC%10(O)CCCCCC%10)ccc19 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 L15 mock treatment 201640.0 -180000.0 -0.9 238180.0 -86800.0 -0.41 -0.9247 -0.9362 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 L16 mock treatment 259310.0 -122000.0 -0.61 215750.0 -109000.0 -0.51 -0.7957 -0.9963 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 L17 compound treatment 249080.0 -133000.0 -0.66 330940.0 5950.0 0.03 -0.4487 -0.6766 2141152 PK04_097231 COc1ccc(C#Cc2ccc3NC(=O)[C@@]4([C@H]([C@H]5N([C@H]4c6ccc(OCCO)cc6)[C@@H]([C@@H](OC5=O)c7ccccc7)c8ccccc8)C(=O)N9CCCCCCC9)c3c2)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 L18 compound treatment 246470.0 -135000.0 -0.68 168210.0 -157000.0 -0.74 -0.9991 -0.999 2143325 PK04_097232 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(OCCO)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N)c7cc(C#CCCO)ccc17 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 L19 compound treatment 186170.0 -196000.0 -0.98 136930.0 -188000.0 -0.88 -1.3161 -0.9988 2141709 PK04_097233 COc1cc2CCN(Cc2cc1OC)C(=O)[C@@H]3[C@@H]4N([C@H](c5ccccc5OCCO)[C@@]36C(=O)Nc7ccc(C#CCCO)cc76)[C@H]([C@H](OC4=O)c8ccccc8)c9ccccc9 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 L20 compound treatment 241720.0 -140000.0 -0.7 204400.0 -121000.0 -0.57 -0.8955 -0.9946 2142773 PK04_097234 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccccc4OCCO)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCN(CC7)c8ncccn8)c9cc(C#CC%10(O)CCCCCC%10)ccc19 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 L21 compound treatment 215410.0 -166000.0 -0.83 360320.0 35300.0 0.17 -0.4699 -0.5546 2141174 PK04_097235 OCCOc1ccc(cc1)[C@@H]2N3[C@H]([C@H](C(=O)N4CCCCCCC4)[C@@]25C(=O)Nc6ccc(C#CCCO)cc65)C(=O)O[C@H]([C@H]3c7ccccc7)c8ccccc8 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 L22 compound treatment 347450.0 -34300.0 -0.17 174000.0 -151000.0 -0.71 -0.6233 -0.8531 2142985 PK04_097236 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(O)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NCC=C)c7cc(C#CCCO)ccc17 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 L23 mock treatment 436120.0 54400.0 0.27 386560.0 61600.0 0.29 0.3969 0.9995 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 L24 mock treatment 324360.0 -57400.0 -0.29 229470.0 -95500.0 -0.45 -0.5203 -0.9764 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 M01 compound treatment 491840.0 110000.0 0.55 457500.0 133000.0 0.62 0.8296 0.9981 2141838 PK04_097237 Oc1ccc(cc1)[C@H]2N3[C@@H]([C@@H](C(=O)Nc4nc5ccccc5s4)[C@]26C(=O)Nc7ccc(C#CC8=CCCCC8)cc76)C(=O)O[C@@H]([C@@H]3c9ccccc9)c%10ccccc%10 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 M02 compound treatment 377890.0 -3840.0 -0.02 341670.0 16700.0 0.08 0.0419 0.5189 2141189 PK04_097238 COC(=O)C(CC#Cc1ccc2NC(=O)[C@@]3([C@H]([C@H]4N([C@H]3c5ccc(OCCO)cc5)[C@@H]([C@@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)Nc8nc9ccccc9s8)c2c1)C(=O)OC 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 M03 compound treatment 203470.0 -178000.0 -0.89 117320.0 -208000.0 -0.98 -1.3203 -0.9989 2141724 PK04_097239 OCCOc1ccccc1[C@H]2N3[C@@H]([C@@H](C(=O)N4CCCCCCC4)[C@]25C(=O)Nc6ccc(C#CC7(O)CCCCCC7)cc65)C(=O)O[C@@H]([C@@H]3c8ccccc8)c9ccccc9 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 M04 compound treatment 171600.0 -210000.0 -1.05 265990.0 -59000.0 -0.28 -0.9383 -0.8644 2141153 PK04_097240 COc1ccc(C#Cc2ccc3NC(=O)[C@@]4([C@H]([C@H]5N([C@H]4c6ccc(OCCO)cc6)[C@@H]([C@@H](OC5=O)c7ccccc7)c8ccccc8)C(=O)NC[C@H](O)c9ccccc9)c3c2)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 M05 compound treatment 515520.0 134000.0 0.67 213860.0 -111000.0 -0.52 0.1029 0.1213 2141436 PK04_097241 OCCC#Cc1ccc2NC(=O)[C@@]3([C@H]([C@H]4N([C@H]3c5ccc(O)cc5)[C@@H]([C@@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)NCC=C)c2c1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 M06 compound treatment 499430.0 118000.0 0.59 360400.0 35400.0 0.17 0.5334 0.8731 2141769 PK04_097242 COc1ccc(C#Cc2ccc3NC(=O)[C@]4([C@@H]([C@@H]5N([C@@H]4c6ccc(O)cc6)[C@H]([C@H](OC5=O)c7ccccc7)c8ccccc8)C(=O)NC[C@H](O)c9ccccc9)c3c2)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 M07 compound treatment 446180.0 64400.0 0.32 148760.0 -176000.0 -0.83 -0.3585 -0.4032 2141771 PK04_097243 COc1ccc(C#Cc2ccc3NC(=O)[C@]4([C@@H]([C@@H]5N([C@@H]4c6ccc(O)cc6)[C@H]([C@H](OC5=O)c7ccccc7)c8ccccc8)C(=O)N)c3c2)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 M08 compound treatment 261370.0 -120000.0 -0.6 221440.0 -104000.0 -0.49 -0.7695 -0.9945 2141480 PK04_097244 Oc1ccc(cc1)[C@@H]2N3[C@H]([C@H](C(=O)NCC=C)[C@@]24C(=O)Nc5ccc(C#CC6=CCCCC6)cc54)C(=O)O[C@H]([C@H]3c7ccccc7)c8ccccc8 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 M09 mock treatment 534400.0 153000.0 0.76 181030.0 -144000.0 -0.68 0.0604 0.0592 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 M10 mock treatment 553640.0 172000.0 0.86 214110.0 -111000.0 -0.52 0.2383 0.2373 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 M11 compound treatment 323360.0 -58400.0 -0.29 115680.0 -209000.0 -0.98 -0.9023 -0.8788 2141571 PK04_097245 OCCOc1ccc(cc1)[C@H]2N3[C@@H]([C@@H](C(=O)NC[C@H](O)c4ccccc4)[C@]25C(=O)Nc6ccc(C#CC7=CCCCC7)cc65)C(=O)O[C@@H]([C@@H]3c8ccccc8)c9ccccc9 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 M12 compound treatment 150690.0 -231000.0 -1.15 82500.0 -242000.0 -1.14 -1.6225 -1.0 2141879 PK04_097246 OCCOc1ccccc1[C@@H]2N3[C@H]([C@H](C(=O)NC[C@H](O)c4ccccc4)[C@@]25C(=O)Nc6ccccc65)C(=O)O[C@H]([C@H]3c7ccccc7)c8ccccc8 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 M13 mock treatment 382640.0 907.0 0.0 432040.0 107000.0 0.5 0.3593 0.7134 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 M14 mock treatment 445180.0 63400.0 0.32 218980.0 -106000.0 -0.5 -0.1285 -0.2175 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 M15 compound treatment 255240.0 -126000.0 -0.63 148160.0 -177000.0 -0.83 -1.0349 -0.9908 2141832 PK04_097247 Oc1ccc(cc1)[C@H]2N3[C@@H]([C@@H](C(=O)NCC=C)[C@]24C(=O)Nc5ccc(C#CC6=CCCCC6)cc54)C(=O)O[C@@H]([C@@H]3c7ccccc7)c8ccccc8 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 M16 compound treatment 396740.0 15000.0 0.07 183080.0 -142000.0 -0.67 -0.419 -0.6238 2141542 PK04_097248 COC(=O)C(CC#Cc1ccc2NC(=O)[C@]3([C@@H]([C@@H]4N([C@@H]3c5ccc(OCCO)cc5)[C@H]([C@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)N8CCN(CC8)c9ncccn9)c2c1)C(=O)OC 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 M17 compound treatment 189020.0 -193000.0 -0.96 170770.0 -154000.0 -0.73 -1.1935 -0.9903 2141399 PK04_097249 OCCOc1ccccc1[C@@H]2N3[C@H]([C@H](C(=O)N4CCN(CC4)c5ncccn5)[C@@]26C(=O)Nc7ccc(C#CC8=CCCCC8)cc76)C(=O)O[C@H]([C@H]3c9ccccc9)c%10ccccc%10 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 M18 compound treatment 334600.0 -47100.0 -0.24 218900.0 -106000.0 -0.5 -0.5193 -0.9412 2141903 PK04_097250 NC(=O)[C@@H]1[C@@H]2N([C@H](c3ccc(OCCO)cc3)[C@@]14C(=O)Nc5ccccc54)[C@H]([C@H](OC2=O)c6ccccc6)c7ccccc7 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 M19 compound treatment 15780.0 -366000.0 -1.83 12650.0 -312000.0 -1.47 -2.3312 -0.9941 2141716 PK04_097251 COC(=O)C(CC#Cc1ccc2NC(=O)[C@]3([C@@H]([C@@H]4N([C@@H]3c5ccccc5OCCO)[C@H]([C@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)N)c2c1)C(=O)OC 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 M20 compound treatment 224990.0 -157000.0 -0.78 243240.0 -81700.0 -0.38 -0.8255 -0.9464 2141203 PK04_097252 COc1cc2CCN(Cc2cc1OC)C(=O)[C@H]3[C@H]4N([C@@H](c5ccc(OCCO)cc5)[C@]36C(=O)Nc7ccc(C#CC8(O)CCCCCC8)cc76)[C@@H]([C@@H](OC4=O)c9ccccc9)c%10ccccc%10 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 M21 compound treatment 178480.0 -203000.0 -1.02 420600.0 95600.0 0.45 -0.3998 -0.3601 2141110 PK04_097253 COC(=O)C(CC#Cc1ccc2NC(=O)[C@@]3([C@H]([C@H]4N([C@H]3c5ccccc5OCCO)[C@@H]([C@@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)O)c2c1)C(=O)OC 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 M22 compound treatment 184420.0 -197000.0 -0.99 167540.0 -157000.0 -0.74 -1.2205 -0.9901 2141731 PK04_097254 COc1cc2CCN(Cc2cc1OC)C(=O)[C@@H]3[C@@H]4N([C@H](c5ccccc5OCCO)[C@@]36C(=O)Nc7ccc(C#CC8(O)CCCCCC8)cc76)[C@H]([C@H](OC4=O)c9ccccc9)c%10ccccc%10 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 M23 compound treatment 268160.0 -114000.0 -0.57 187880.0 -137000.0 -0.64 -0.8571 -0.998 2141095 PK04_097255 OCCOc1ccc(cc1)[C@@H]2N3[C@H]([C@H](C(=O)O)[C@@]24C(=O)Nc5ccc(C#CC6(O)CCCCCC6)cc54)C(=O)O[C@H]([C@H]3c7ccccc7)c8ccccc8 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 M24 compound treatment 463300.0 81600.0 0.41 355750.0 30800.0 0.14 0.3904 0.903 2141894 PK04_097256 Oc1ccc(cc1)[C@@H]2N3[C@H]([C@H](C(=O)N4CCN(CC4)c5ncccn5)[C@@]26C(=O)Nc7ccccc76)C(=O)O[C@H]([C@H]3c8ccccc8)c9ccccc9 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 N01 compound treatment 457930.0 76200.0 0.38 319010.0 -5980.0 -0.03 0.2492 0.6531 2141340 PK04_097257 NC(=O)NCC#Cc1ccc2NC(=O)[C@@]3([C@H]([C@H]4N([C@H]3c5ccccc5OCCO)[C@@H]([C@@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)NC[C@H](O)c8ccccc8)c2c1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 N02 compound treatment 438170.0 56400.0 0.28 438460.0 113000.0 0.53 0.5767 0.9555 2142089 PK04_097258 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(OCCO)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)Nc7nc8ccccc8s7)c9cc(C#CCC(C(=O)OC)C(=O)OC)ccc19 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 N03 compound treatment 450730.0 69000.0 0.34 382660.0 57700.0 0.27 0.4355 0.993 2141511 PK04_097259 COc1ccc(C#Cc2ccc3NC(=O)[C@]4([C@@H]([C@@H]5N([C@@H]4c6ccc(OCCO)cc6)[C@H]([C@H](OC5=O)c7ccccc7)c8ccccc8)C(=O)N9CCc%10cc(OC)c(OC)cc%10C9)c3c2)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 N04 compound treatment 240890.0 -141000.0 -0.7 445490.0 121000.0 0.57 -0.0966 -0.107 2144305 PK04_097260 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(O)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NCC=C)c7cc(C#CCC(C(=O)OC)C(=O)OC)ccc17 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 N05 compound treatment 222750.0 -159000.0 -0.79 109040.0 -216000.0 -1.02 -1.2797 -0.9926 2141839 PK04_097261 Oc1ccc(cc1)[C@H]2N3[C@@H]([C@@H](C(=O)N4CCN(CC4)c5ncccn5)[C@]26C(=O)Nc7ccc(C#CC8=CCCCC8)cc76)C(=O)O[C@@H]([C@@H]3c9ccccc9)c%10ccccc%10 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 N06 compound treatment 495390.0 114000.0 0.57 349850.0 24900.0 0.12 0.4841 0.8352 2142057 PK04_097262 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(OCCO)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCc8cc(OC)c(OC)cc8C7)c9cc(C#CCCO)ccc19 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 N07 compound treatment 193700.0 -188000.0 -0.94 169150.0 -156000.0 -0.73 -1.1824 -0.9925 2141431 PK04_097263 NC(=O)NCC#Cc1ccc2NC(=O)[C@@]3([C@H]([C@H]4N([C@H]3c5ccc(O)cc5)[C@@H]([C@@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)Nc8nc9ccccc9s8)c2c1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 N08 compound treatment 453150.0 71400.0 0.36 257810.0 -67200.0 -0.32 0.0288 0.0604 2144369 PK04_097264 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(O)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)Nc7nc8ccccc8s7)c9cc(C#CC%10(O)CCCCCC%10)ccc19 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 N09 mock treatment 506620.0 125000.0 0.62 216710.0 -108000.0 -0.51 0.0809 0.1005 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 N10 mock treatment 391300.0 9570.0 0.05 442240.0 117000.0 0.55 0.4238 0.7655 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 N11 compound treatment 471170.0 89400.0 0.45 299680.0 -25300.0 -0.12 0.2317 0.5012 2141527 PK04_097265 OCCOc1ccc(cc1)[C@H]2N3[C@@H]([C@@H](C(=O)NC[C@H](O)c4ccccc4)[C@]25C(=O)Nc6ccc(C#CCCO)cc65)C(=O)O[C@@H]([C@@H]3c7ccccc7)c8ccccc8 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 N12 compound treatment 393620.0 11900.0 0.06 222310.0 -103000.0 -0.48 -0.2995 -0.6155 2144009 PK04_097266 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccccc4OCCO)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)Nc7nc8ccccc8s7)c9cc(C#CCC(C(=O)OC)C(=O)OC)ccc19 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 N13 mock treatment 221780.0 -160000.0 -0.8 214780.0 -110000.0 -0.52 -0.9314 -0.9781 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 N14 mock treatment 212000.0 -170000.0 -0.85 361630.0 36600.0 0.17 -0.4776 -0.552 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 N15 compound treatment 275520.0 -106000.0 -0.53 269540.0 -55400.0 -0.26 -0.5595 -0.9465 2141907 PK04_097267 COc1cc2CCN(Cc2cc1OC)C(=O)[C@@H]3[C@@H]4N([C@H](c5ccc(OCCO)cc5)[C@@]36C(=O)Nc7ccccc76)[C@H]([C@H](OC4=O)c8ccccc8)c9ccccc9 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 N16 compound treatment 233870.0 -148000.0 -0.74 205730.0 -119000.0 -0.56 -0.9188 -0.9908 2143157 PK04_097268 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(O)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NC[C@H](O)c7ccccc7)c8cc(C#CC9=CCCCC9)ccc18 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 N17 compound treatment 253570.0 -128000.0 -0.64 276850.0 -48100.0 -0.23 -0.6127 -0.9024 2141544 PK04_097269 COC(=O)C(CC#Cc1ccc2NC(=O)[C@]3([C@@H]([C@@H]4N([C@@H]3c5ccc(OCCO)cc5)[C@H]([C@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)N8CCc9cc(OC)c(OC)cc9C8)c2c1)C(=O)OC 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 N18 compound treatment 233810.0 -148000.0 -0.74 355290.0 30300.0 0.14 -0.4216 -0.5604 2144297 PK04_097270 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(O)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCc8cc(OC)c(OC)cc8C7)c9cc(C#CCCO)ccc19 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 N19 compound treatment 182120.0 -200000.0 -1.0 147630.0 -177000.0 -0.83 -1.2948 -0.9961 2141483 PK04_097271 O[C@@H](CNC(=O)[C@H]1[C@H]2N([C@@H](c3ccc(O)cc3)[C@]14C(=O)Nc5ccc(C#CC6=CCCCC6)cc54)[C@@H]([C@@H](OC2=O)c7ccccc7)c8ccccc8)c9ccccc9 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 N20 compound treatment 345190.0 -36500.0 -0.18 340240.0 15300.0 0.07 -0.0783 -0.3994 2142217 PK04_097272 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(OCCO)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCc8cc(OC)c(OC)cc8C7)c9cc(C#CC%10=CCCCC%10)ccc19 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 N21 compound treatment 338100.0 -43600.0 -0.22 221570.0 -103000.0 -0.49 -0.4981 -0.9344 2141887 PK04_097273 Oc1ccc(cc1)[C@@H]2N3[C@H]([C@H](C(=O)NCC=C)[C@@]24C(=O)Nc5ccccc54)C(=O)O[C@H]([C@H]3c6ccccc6)c7ccccc7 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 N22 compound treatment 309040.0 -72700.0 -0.36 377360.0 52400.0 0.25 -0.0825 -0.1881 2143065 PK04_097274 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(O)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NCC=C)c7cc(C#CC8(O)CCCCCC8)ccc17 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 N23 compound treatment 283330.0 -98400.0 -0.49 147590.0 -177000.0 -0.83 -0.9375 -0.9681 2141817 PK04_097275 Oc1ccc(cc1)[C@H]2N3[C@@H]([C@@H](C(=O)N4CCN(CC4)c5ncccn5)[C@]26C(=O)Nc7ccc(C#CC8(O)CCCCCC8)cc76)C(=O)O[C@@H]([C@@H]3c9ccccc9)c%10ccccc%10 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 N24 compound treatment 468180.0 86400.0 0.43 427920.0 103000.0 0.48 0.6477 0.9984 2144333 PK04_097276 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(O)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCN(CC7)c8ncccn8)c9cc(C#CCC(C(=O)OC)C(=O)OC)ccc19 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 O01 compound treatment 544200.0 162000.0 0.81 352660.0 27700.0 0.13 0.6658 0.8102 2141166 PK04_097277 NC(=O)NCC#Cc1ccc2NC(=O)[C@@]3([C@H]([C@H]4N([C@H]3c5ccc(OCCO)cc5)[C@@H]([C@@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)N)c2c1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 O02 compound treatment 339650.0 -42100.0 -0.21 247790.0 -77200.0 -0.36 -0.4054 -0.9662 2141900 PK04_097278 OCCOc1ccc(cc1)[C@H]2N3[C@@H]([C@@H](C(=O)N4CCCCCCC4)[C@]25C(=O)Nc6ccccc65)C(=O)O[C@@H]([C@@H]3c7ccccc7)c8ccccc8 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 O03 compound treatment 461960.0 80200.0 0.4 292370.0 -32600.0 -0.15 0.1749 0.4075 2141790 PK04_097279 OCCC#Cc1ccc2NC(=O)[C@]3([C@@H]([C@@H]4N([C@@H]3c5ccc(O)cc5)[C@H]([C@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)N8CCCCCCC8)c2c1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 O04 compound treatment 280450.0 -101000.0 -0.51 133600.0 -191000.0 -0.9 -0.9942 -0.9628 2141883 PK04_097280 OCCOc1ccccc1[C@@H]2N3[C@H]([C@H](C(=O)N4CCN(CC4)c5ncccn5)[C@@]26C(=O)Nc7ccccc76)C(=O)O[C@H]([C@H]3c8ccccc8)c9ccccc9 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 O05 compound treatment 478030.0 96300.0 0.48 157570.0 -167000.0 -0.79 -0.2167 -0.2349 2141427 PK04_097281 NC(=O)NCC#Cc1ccc2NC(=O)[C@@]3([C@H]([C@H]4N([C@H]3c5ccc(O)cc5)[C@@H]([C@@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)N8CCCCCCC8)c2c1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 O06 compound treatment 502180.0 120000.0 0.6 451050.0 126000.0 0.59 0.8447 1.0 2141093 PK04_097282 OCCOc1ccc(cc1)[C@@H]2N3[C@H]([C@H](C(=O)O)[C@@]24C(=O)Nc5ccc(C#CCCO)cc54)C(=O)O[C@H]([C@H]3c6ccccc6)c7ccccc7 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 O07 compound treatment 341700.0 -40000.0 -0.2 166460.0 -159000.0 -0.75 -0.6686 -0.8661 2141812 PK04_097283 Oc1ccc(cc1)[C@H]2N3[C@@H]([C@@H](C(=O)N4CCCCCCC4)[C@]25C(=O)Nc6ccc(C#CC7(O)CCCCCC7)cc65)C(=O)O[C@@H]([C@@H]3c8ccccc8)c9ccccc9 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 O08 compound treatment 461280.0 79500.0 0.4 450100.0 125000.0 0.59 0.6971 0.9817 2141430 PK04_097284 NC(=O)NCC#Cc1ccc2NC(=O)[C@@]3([C@H]([C@H]4N([C@H]3c5ccc(O)cc5)[C@@H]([C@@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)N)c2c1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 O09 compound treatment 281080.0 -101000.0 -0.5 201920.0 -123000.0 -0.58 -0.7648 -0.9975 2141454 PK04_097285 COC(=O)C(CC#Cc1ccc2NC(=O)[C@@]3([C@H]([C@H]4N([C@H]3c5ccc(O)cc5)[C@@H]([C@@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)N8CCN(CC8)c9ncccn9)c2c1)C(=O)OC 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 O10 compound treatment 323590.0 -58100.0 -0.29 195520.0 -129000.0 -0.61 -0.6359 -0.9426 2141529 PK04_097286 NC(=O)[C@@H]1[C@@H]2N([C@H](c3ccc(OCCO)cc3)[C@@]14C(=O)Nc5ccc(C#CCCO)cc54)[C@H]([C@H](OC2=O)c6ccccc6)c7ccccc7 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 O11 mock treatment 481680.0 99900.0 0.5 480640.0 156000.0 0.73 0.8707 0.9826 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 O12 mock treatment 280010.0 -102000.0 -0.51 372240.0 47300.0 0.22 -0.2021 -0.3644 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 O13 compound treatment 303390.0 -78300.0 -0.39 263690.0 -61300.0 -0.29 -0.4806 -0.9887 2141368 PK04_097287 COC(=O)C(CC#Cc1ccc2NC(=O)[C@@]3([C@H]([C@H]4N([C@H]3c5ccccc5OCCO)[C@@H]([C@@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)N8CCc9cc(OC)c(OC)cc9C8)c2c1)C(=O)OC 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 O14 compound treatment 488170.0 106000.0 0.53 335520.0 10500.0 0.05 0.4109 0.7697 2141362 PK04_097288 COC(=O)C(CC#Cc1ccc2NC(=O)[C@@]3([C@H]([C@H]4N([C@H]3c5ccccc5OCCO)[C@@H]([C@@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)NC[C@H](O)c8ccccc8)c2c1)C(=O)OC 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 O15 compound treatment 503460.0 122000.0 0.61 357310.0 32300.0 0.15 0.5374 0.8575 2141460 PK04_097289 Oc1ccc(cc1)[C@@H]2N3[C@H]([C@H](C(=O)N4CCCCCCC4)[C@@]25C(=O)Nc6ccc(C#CC7(O)CCCCCC7)cc65)C(=O)O[C@H]([C@H]3c8ccccc8)c9ccccc9 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 O16 compound treatment 260200.0 -122000.0 -0.61 172610.0 -152000.0 -0.72 -0.936 -0.9966 2141860 PK04_097290 OCCOc1ccc(cc1)[C@@H]2N3[C@H]([C@H](C(=O)Nc4nc5ccccc5s4)[C@@]26C(=O)Nc7ccccc76)C(=O)O[C@H]([C@H]3c8ccccc8)c9ccccc9 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 O17 compound treatment 390010.0 8280.0 0.04 260320.0 -64700.0 -0.3 -0.1858 -0.6054 2141175 PK04_097291 OCCOc1ccc(cc1)[C@@H]2N3[C@H]([C@H](C(=O)NC[C@H](O)c4ccccc4)[C@@]25C(=O)Nc6ccc(C#CCCO)cc65)C(=O)O[C@H]([C@H]3c7ccccc7)c8ccccc8 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 O18 compound treatment 303720.0 -78000.0 -0.39 239930.0 -85100.0 -0.4 -0.5584 -0.9999 2141486 PK04_097292 Oc1ccc(cc1)[C@@H]2N3[C@H]([C@H](C(=O)Nc4nc5ccccc5s4)[C@@]26C(=O)Nc7ccc(C#CC8=CCCCC8)cc76)C(=O)O[C@H]([C@H]3c9ccccc9)c%10ccccc%10 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 O19 compound treatment 178950.0 -203000.0 -1.01 119610.0 -205000.0 -0.97 -1.3992 -0.9997 2141156 PK04_097293 COc1ccc(C#Cc2ccc3NC(=O)[C@@]4([C@H]([C@H]5N([C@H]4c6ccc(OCCO)cc6)[C@@H]([C@@H](OC5=O)c7ccccc7)c8ccccc8)C(=O)Nc9nc%10ccccc%10s9)c3c2)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 O20 compound treatment 300020.0 -81700.0 -0.41 213660.0 -111000.0 -0.52 -0.6589 -0.9924 2141685 PK04_097294 COc1ccc(C#Cc2ccc3NC(=O)[C@]4([C@@H]([C@@H]5N([C@@H]4c6ccccc6OCCO)[C@H]([C@H](OC5=O)c7ccccc7)c8ccccc8)C(=O)N9CCN(CC9)c%10ncccn%10)c3c2)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 O21 compound treatment 169550.0 -212000.0 -1.06 176590.0 -148000.0 -0.7 -1.2429 -0.9795 2141094 PK04_097295 COC(=O)C(CC#Cc1ccc2NC(=O)[C@@]3([C@H]([C@H]4N([C@H]3c5ccc(OCCO)cc5)[C@@H]([C@@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)O)c2c1)C(=O)OC 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 O22 compound treatment 191680.0 -190000.0 -0.95 203450.0 -122000.0 -0.57 -1.0754 -0.9705 2141379 PK04_097296 COc1cc2CCN(Cc2cc1OC)C(=O)[C@H]3[C@H]4N([C@@H](c5ccccc5OCCO)[C@]36C(=O)Nc7ccc(C#CC8(O)CCCCCC8)cc76)[C@@H]([C@@H](OC4=O)c9ccccc9)c%10ccccc%10 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 O23 compound treatment 237620.0 -144000.0 -0.72 189210.0 -136000.0 -0.64 -0.9605 -0.9982 2141397 PK04_097297 NC(=O)[C@H]1[C@H]2N([C@@H](c3ccccc3OCCO)[C@]14C(=O)Nc5ccc(C#CC6=CCCCC6)cc54)[C@@H]([C@@H](OC2=O)c7ccccc7)c8ccccc8 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 O24 compound treatment 285760.0 -96000.0 -0.48 242050.0 -82900.0 -0.39 -0.6148 -0.9948 2065842 PK04_097298 COC(=O)C(CC#Cc1ccc2NC(=O)[C@]3([C@@H]([C@@H]4N([C@@H]3c5ccc(OCCO)cc5)[C@H]([C@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)O)c2c1)C(=O)OC 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 P01 compound treatment 112600.0 -269000.0 -1.34 211070.0 -114000.0 -0.54 -1.3294 -0.9187 2141898 PK04_097299 OCCOc1ccc(cc1)[C@H]2N3[C@@H]([C@@H](C(=O)NCC=C)[C@]24C(=O)Nc5ccccc54)C(=O)O[C@@H]([C@@H]3c6ccccc6)c7ccccc7 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 P02 compound treatment 342140.0 -39600.0 -0.2 285440.0 -39500.0 -0.19 -0.2714 -0.9995 2143305 PK04_097300 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(OCCO)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NCC=C)c7cc(C#CCCO)ccc17 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 P03 compound treatment 399850.0 18100.0 0.09 334010.0 9020.0 0.04 0.094 0.9404 2141555 PK04_097301 COc1cc2CCN(Cc2cc1OC)C(=O)[C@@H]3[C@@H]4N([C@H](c5ccc(OCCO)cc5)[C@@]36C(=O)Nc7ccc(C#CC8(O)CCCCCC8)cc76)[C@H]([C@H](OC4=O)c9ccccc9)c%10ccccc%10 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 P04 compound treatment 164610.0 -217000.0 -1.08 122990.0 -202000.0 -0.95 -1.4386 -0.9978 2144945 PK04_097302 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(O)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCc8cc(OC)c(OC)cc8C7)c9ccccc19 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 P05 compound treatment 62080.0 -320000.0 -1.6 45710.0 -279000.0 -1.31 -2.0578 -0.9953 2141923 PK04_097303 OCCOc1ccccc1[C@H]2N3[C@@H]([C@@H](C(=O)NC[C@H](O)c4ccccc4)[C@]25C(=O)Nc6ccccc65)C(=O)O[C@@H]([C@@H]3c7ccccc7)c8ccccc8 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 P06 compound treatment 151110.0 -231000.0 -1.15 272920.0 -52100.0 -0.24 -0.9877 -0.8387 2144433 PK04_097304 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(O)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCCCCCC7)c8cc(C#CC9=CCCCC9)ccc18 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 P07 compound treatment 196480.0 -185000.0 -0.93 160030.0 -165000.0 -0.78 -1.2029 -0.9962 2141482 PK04_097305 Oc1ccc(cc1)[C@@H]2N3[C@H]([C@H](C(=O)N4CCCCCCC4)[C@@]25C(=O)Nc6ccc(C#CC7=CCCCC7)cc65)C(=O)O[C@H]([C@H]3c8ccccc8)c9ccccc9 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 P08 compound treatment 203630.0 -178000.0 -0.89 308450.0 -16500.0 -0.08 -0.684 -0.766 2143929 PK04_097306 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccccc4OCCO)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)Nc7nc8ccccc8s7)c9cc(C#CCNC(=O)N)ccc19 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 P09 compound treatment 212180.0 -170000.0 -0.85 200960.0 -124000.0 -0.58 -1.0113 -0.9835 2141698 PK04_097307 COc1cc2CCN(Cc2cc1OC)C(=O)[C@@H]3[C@@H]4N([C@H](c5ccccc5OCCO)[C@@]36C(=O)Nc7ccc(C#CCNC(=O)N)cc76)[C@H]([C@H](OC4=O)c8ccccc8)c9ccccc9 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 P10 compound treatment 241070.0 -141000.0 -0.7 217200.0 -108000.0 -0.51 -0.8553 -0.9872 2142653 PK04_097308 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccccc4OCCO)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCN(CC7)c8ncccn8)c9cc(C#CCNC(=O)N)ccc19 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 P11 mock treatment 164110.0 -218000.0 -1.09 170120.0 -155000.0 -0.73 -1.2837 -0.9811 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 P12 mock treatment 177760.0 -204000.0 -1.02 160420.0 -165000.0 -0.77 -1.2677 -0.9908 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 P13 compound treatment 196890.0 -185000.0 -0.92 438960.0 114000.0 0.54 -0.2737 -0.2564 2141449 PK04_097309 COC(=O)C(CC#Cc1ccc2NC(=O)[C@@]3([C@H]([C@H]4N([C@H]3c5ccc(O)cc5)[C@@H]([C@@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)N8CCCCCCC8)c2c1)C(=O)OC 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 P14 compound treatment 216480.0 -165000.0 -0.83 218190.0 -107000.0 -0.5 -0.9388 -0.9717 2144933 PK04_097310 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(O)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N)c7ccccc17 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 P15 compound treatment 285930.0 -95800.0 -0.48 184670.0 -140000.0 -0.66 -0.805 -0.9875 2141416 PK04_097311 COc1ccc(C#Cc2ccc3NC(=O)[C@@]4([C@H]([C@H]5N([C@H]4c6ccc(O)cc6)[C@@H]([C@@H](OC5=O)c7ccccc7)c8ccccc8)C(=O)N9CCCCCCC9)c3c2)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 P16 compound treatment 215750.0 -166000.0 -0.83 166080.0 -159000.0 -0.75 -1.1147 -0.9987 2144445 PK04_097312 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(O)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N)c7cc(C#CC8=CCCCC8)ccc17 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 P17 compound treatment 391630.0 9900.0 0.05 171740.0 -153000.0 -0.72 -0.4747 -0.6571 2141453 PK04_097313 COC(=O)C(CC#Cc1ccc2NC(=O)[C@@]3([C@H]([C@H]4N([C@H]3c5ccc(O)cc5)[C@@H]([C@@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)Nc8nc9ccccc9s8)c2c1)C(=O)OC 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 P18 compound treatment 103840.0 -278000.0 -1.39 88930.0 -236000.0 -1.11 -1.7665 -0.9939 2142745 PK04_097314 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccccc4OCCO)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NCC=C)c7cc(C#CC8(O)CCCCCC8)ccc17 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 P19 compound treatment 261040.0 -121000.0 -0.6 223560.0 -101000.0 -0.48 -0.7636 -0.9933 2141541 PK04_097315 COC(=O)C(CC#Cc1ccc2NC(=O)[C@]3([C@@H]([C@@H]4N([C@@H]3c5ccc(OCCO)cc5)[C@H]([C@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)Nc8nc9ccccc9s8)c2c1)C(=O)OC 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 P20 compound treatment 276190.0 -106000.0 -0.53 263740.0 -61200.0 -0.29 -0.5764 -0.9596 2142193 PK04_097316 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(OCCO)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCCCCCC7)c8cc(C#CC9=CCCCC9)ccc18 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 P21 compound treatment 187240.0 -194000.0 -0.97 181850.0 -143000.0 -0.67 -1.163 -0.984 2141134 PK04_097317 NC(=O)NCC#Cc1ccc2NC(=O)[C@]3([C@@H]([C@@H]4N([C@@H]3c5ccccc5OCCO)[C@H]([C@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)O)c2c1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 P22 compound treatment 387650.0 5920.0 0.03 351800.0 26800.0 0.13 0.1101 0.8498 2142729 PK04_097318 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccccc4OCCO)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)Nc7nc8ccccc8s7)c9cc(C#CCC(C(=O)OC)C(=O)OC)ccc19 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 P23 compound treatment 361790.0 -19900.0 -0.1 287360.0 -37600.0 -0.18 -0.1956 -0.963 2141121 PK04_097319 OC(=O)[C@H]1[C@H]2N([C@@H](c3ccc(O)cc3)[C@]14C(=O)Nc5ccc(C#CC6=CCCCC6)cc54)[C@@H]([C@@H](OC2=O)c7ccccc7)c8ccccc8 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2097 P24 compound treatment 198310.0 -183000.0 -0.92 228590.0 -96400.0 -0.45 -0.9684 -0.9474 2144273 PK04_097320 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(O)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCCCCCC7)c8cc(C#CCCO)ccc18 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 A01 compound treatment 177140.0 -293000.0 -1.46 476280.0 64900.0 0.31 -0.8177 -0.5476 2141696 PK04_098001 NC(=O)NCC#Cc1ccc2NC(=O)[C@]3([C@@H]([C@@H]4N([C@@H]3c5ccccc5OCCO)[C@H]([C@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)N8CCN(CC8)c9ncccn9)c2c1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 A02 compound treatment 180160.0 -290000.0 -1.45 161440.0 -250000.0 -1.18 -1.8542 -0.9947 2144133 PK04_098002 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccccc4OCCO)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCN(CC7)c8ncccn8)c9cc(C#CC%10=CCCCC%10)ccc19 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 A03 compound treatment 299010.0 -171000.0 -0.85 318850.0 -92500.0 -0.44 -0.9109 -0.9513 2141089 PK04_098003 OCCOc1ccccc1[C@H]2N3[C@@H]([C@@H](C(=O)O)[C@]24C(=O)Nc5ccccc54)C(=O)O[C@@H]([C@@H]3c6ccccc6)c7ccccc7 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 A04 compound treatment 291200.0 -179000.0 -0.89 220730.0 -191000.0 -0.9 -1.2648 -1.0 2142093 PK04_098004 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(OCCO)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCN(CC7)c8ncccn8)c9cc(C#CCC(C(=O)OC)C(=O)OC)ccc19 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 A05 compound treatment 120660.0 -349000.0 -1.74 108320.0 -303000.0 -1.43 -2.241 -0.995 2141744 PK04_098005 OCCOc1ccccc1[C@H]2N3[C@@H]([C@@H](C(=O)NCC=C)[C@]24C(=O)Nc5ccc(C#CC6=CCCCC6)cc54)C(=O)O[C@@H]([C@@H]3c7ccccc7)c8ccccc8 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 A06 compound treatment 204510.0 -265000.0 -1.32 339040.0 -72300.0 -0.34 -1.1775 -0.8608 2143237 PK04_098006 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(OCCO)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NC[C@H](O)c7ccccc7)c8cc(C#Cc9ccc(OC)cc9)ccc18 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 A07 compound treatment 297170.0 -173000.0 -0.86 221530.0 -190000.0 -0.89 -1.2411 -0.9998 2141337 PK04_098007 NC(=O)NCC#Cc1ccc2NC(=O)[C@@]3([C@H]([C@H]4N([C@H]3c5ccccc5OCCO)[C@@H]([C@@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)NCC=C)c2c1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 A08 compound treatment 388370.0 -81400.0 -0.41 153770.0 -258000.0 -1.21 -1.1444 -0.8953 2144129 PK04_098008 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccccc4OCCO)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)Nc7nc8ccccc8s7)c9cc(C#CC%10=CCCCC%10)ccc19 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 A09 compound treatment 157470.0 -312000.0 -1.56 421190.0 9800.0 0.05 -1.0704 -0.6859 2141791 PK04_098009 OCCC#Cc1ccc2NC(=O)[C@]3([C@@H]([C@@H]4N([C@@H]3c5ccc(O)cc5)[C@H]([C@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)NC[C@H](O)c8ccccc8)c2c1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 A10 compound treatment 250750.0 -219000.0 -1.09 414400.0 3010.0 0.01 -0.7635 -0.6979 2144193 PK04_098010 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(O)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCCCCCC7)c8cc(C#Cc9ccc(OC)cc9)ccc18 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 A11 compound treatment 170110.0 -300000.0 -1.5 132200.0 -279000.0 -1.31 -1.9869 -0.9979 2141133 PK04_098011 COc1ccc(C#Cc2ccc3NC(=O)[C@]4([C@@H]([C@@H]5N([C@@H]4c6ccccc6OCCO)[C@H]([C@H](OC5=O)c7ccccc7)c8ccccc8)C(=O)O)c3c2)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 A12 compound treatment 352220.0 -118000.0 -0.59 307130.0 -104000.0 -0.49 -0.762 -0.996 2143993 PK04_098012 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccccc4OCCO)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCCCCCC7)c8cc(C#CCC(C(=O)OC)C(=O)OC)ccc18 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 A13 mock treatment 447870.0 -21900.0 -0.11 316930.0 -94500.0 -0.44 -0.3916 -0.8557 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 A14 mock treatment 188660.0 -281000.0 -1.4 188370.0 -223000.0 -1.05 -1.7346 -0.9897 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 A15 compound treatment 196840.0 -273000.0 -1.36 204440.0 -207000.0 -0.97 -1.6523 -0.9864 2141695 PK04_098013 NC(=O)NCC#Cc1ccc2NC(=O)[C@]3([C@@H]([C@@H]4N([C@@H]3c5ccccc5OCCO)[C@H]([C@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)Nc8nc9ccccc9s8)c2c1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 A16 compound treatment 362400.0 -107000.0 -0.54 247360.0 -164000.0 -0.77 -0.9248 -0.9842 2144913 PK04_098014 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(O)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NCC=C)c7ccccc17 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 A17 compound treatment 325710.0 -144000.0 -0.72 503320.0 91900.0 0.43 -0.2031 -0.2419 2141801 PK04_098015 COC(=O)C(CC#Cc1ccc2NC(=O)[C@]3([C@@H]([C@@H]4N([C@@H]3c5ccc(O)cc5)[C@H]([C@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)N8CCCCCCC8)c2c1)C(=O)OC 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 A18 compound treatment 205180.0 -265000.0 -1.32 262480.0 -149000.0 -0.7 -1.4298 -0.9559 2142117 PK04_098016 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(OCCO)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NC[C@H](O)c7ccccc7)c8cc(C#CC9(O)CCCCCC9)ccc18 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 A19 compound treatment 435040.0 -34700.0 -0.17 215760.0 -196000.0 -0.92 -0.7734 -0.8259 2141835 PK04_098017 O[C@@H](CNC(=O)[C@@H]1[C@@H]2N([C@H](c3ccc(O)cc3)[C@@]14C(=O)Nc5ccc(C#CC6=CCCCC6)cc54)[C@H]([C@H](OC2=O)c7ccccc7)c8ccccc8)c9ccccc9 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 A20 compound treatment 345440.0 -124000.0 -0.62 227170.0 -184000.0 -0.87 -1.0519 -0.9867 2144205 PK04_098018 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(O)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N)c7cc(C#Cc8ccc(OC)cc8)ccc17 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 A21 compound treatment 261860.0 -208000.0 -1.04 194780.0 -217000.0 -1.02 -1.4548 -1.0 2141920 PK04_098019 OCCOc1ccccc1[C@H]2N3[C@@H]([C@@H](C(=O)NCC=C)[C@]24C(=O)Nc5ccccc54)C(=O)O[C@@H]([C@@H]3c6ccccc6)c7ccccc7 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 A22 compound treatment 309790.0 -160000.0 -0.8 220600.0 -191000.0 -0.9 -1.1996 -0.9983 2141945 PK04_098020 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(OCCO)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NCC=C)c7cc(C#Cc8ccc(OC)cc8)ccc17 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 A23 compound treatment 198100.0 -272000.0 -1.36 342080.0 -69300.0 -0.33 -1.19 -0.8527 2141111 PK04_098021 OCCOc1ccccc1[C@@H]2N3[C@H]([C@H](C(=O)O)[C@@]24C(=O)Nc5ccc(C#CC6(O)CCCCCC6)cc54)C(=O)O[C@H]([C@H]3c7ccccc7)c8ccccc8 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 A24 compound treatment 187460.0 -282000.0 -1.41 179490.0 -232000.0 -1.09 -1.7684 -0.9919 2143385 PK04_098022 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(OCCO)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NCC=C)c7cc(C#CC8(O)CCCCCC8)ccc17 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 B01 compound treatment 102920.0 -367000.0 -1.83 126510.0 -285000.0 -1.34 -2.2431 -0.9882 2142845 PK04_098023 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccccc4OCCO)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N)c7cc(C#CC8=CCCCC8)ccc17 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 B02 compound treatment 531200.0 61400.0 0.31 349290.0 -62100.0 -0.29 0.0104 0.0245 2143009 PK04_098024 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(O)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)Nc7nc8ccccc8s7)c9cc(C#CCCO)ccc19 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 B03 compound treatment 509600.0 39800.0 0.2 240510.0 -171000.0 -0.8 -0.4277 -0.5166 2144209 PK04_098025 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(O)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)Nc7nc8ccccc8s7)c9cc(C#Cc%10ccc(OC)cc%10)ccc19 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 B04 compound treatment 448800.0 -21000.0 -0.1 307050.0 -104000.0 -0.49 -0.4211 -0.8392 2142037 PK04_098026 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(OCCO)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NC[C@H](O)c7ccccc7)c8cc(C#CCCO)ccc18 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 B05 compound treatment 547480.0 77700.0 0.39 325700.0 -85700.0 -0.4 -0.0106 -0.019 2144313 PK04_098027 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(O)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCCCCCC7)c8cc(C#CCC(C(=O)OC)C(=O)OC)ccc18 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 B06 compound treatment 177010.0 -293000.0 -1.46 196420.0 -215000.0 -1.01 -1.749 -0.9838 2143245 PK04_098028 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(OCCO)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N)c7cc(C#Cc8ccc(OC)cc8)ccc17 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 B07 compound treatment 369530.0 -100000.0 -0.5 355970.0 -55400.0 -0.26 -0.5384 -0.9537 2144661 PK04_098029 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(OCCO)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCN(CC7)c8ncccn8)c9ccccc19 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 B08 compound treatment 210480.0 -259000.0 -1.3 237350.0 -174000.0 -0.82 -1.4946 -0.9755 2143409 PK04_098030 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(OCCO)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)Nc7nc8ccccc8s7)c9cc(C#CC%10(O)CCCCCC%10)ccc19 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 B09 compound treatment 448520.0 -21300.0 -0.11 241710.0 -170000.0 -0.8 -0.6394 -0.7942 2144745 PK04_098031 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccccc4OCCO)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCc8cc(OC)c(OC)cc8C7)c9ccccc19 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 B10 compound treatment 557700.0 87900.0 0.44 404650.0 -6740.0 -0.03 0.2881 0.6544 2143049 PK04_098032 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(O)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)Nc7nc8ccccc8s7)c9cc(C#CCC(C(=O)OC)C(=O)OC)ccc19 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 B11 compound treatment 422120.0 -47700.0 -0.24 488320.0 76900.0 0.36 0.0875 0.2021 2143257 PK04_098033 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(OCCO)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCc8cc(OC)c(OC)cc8C7)c9cc(C#Cc%10ccc(OC)cc%10)ccc19 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 B12 compound treatment 177000.0 -293000.0 -1.46 229960.0 -181000.0 -0.85 -1.6374 -0.9671 2141502 PK04_098034 COc1ccc(C#Cc2ccc3NC(=O)[C@]4([C@@H]([C@@H]5N([C@@H]4c6ccc(OCCO)cc6)[C@H]([C@H](OC5=O)c7ccccc7)c8ccccc8)C(=O)NCC=C)c3c2)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 B13 mock treatment 496420.0 26600.0 0.13 524800.0 113000.0 0.53 0.4713 0.8572 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 B14 mock treatment 499200.0 29400.0 0.15 479060.0 67700.0 0.32 0.329 0.9383 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 B15 compound treatment 289920.0 -180000.0 -0.9 237030.0 -174000.0 -0.82 -1.2151 -0.999 2142113 PK04_098035 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(OCCO)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCCCCCC7)c8cc(C#CC9(O)CCCCCC9)ccc18 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 B16 compound treatment 577730.0 108000.0 0.54 505720.0 94300.0 0.44 0.695 0.9953 2141859 PK04_098036 NC(=O)[C@H]1[C@H]2N([C@@H](c3ccc(OCCO)cc3)[C@]14C(=O)Nc5ccccc54)[C@@H]([C@@H](OC2=O)c6ccccc6)c7ccccc7 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 B17 compound treatment 285010.0 -185000.0 -0.92 297490.0 -114000.0 -0.54 -1.0314 -0.9665 2144033 PK04_098037 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccccc4OCCO)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCCCCCC7)c8cc(C#CC9(O)CCCCCC9)ccc18 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 B18 compound treatment 549600.0 79800.0 0.4 473440.0 62100.0 0.29 0.4883 0.9883 2141540 PK04_098038 COC(=O)C(CC#Cc1ccc2NC(=O)[C@]3([C@@H]([C@@H]4N([C@@H]3c5ccc(OCCO)cc5)[C@H]([C@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)N)c2c1)C(=O)OC 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 B19 compound treatment 524800.0 55000.0 0.27 445500.0 34100.0 0.16 0.3077 0.9672 2144437 PK04_098039 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(O)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NC[C@H](O)c7ccccc7)c8cc(C#CC9=CCCCC9)ccc18 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 B20 compound treatment 124050.0 -346000.0 -1.73 116340.0 -295000.0 -1.39 -2.2023 -0.9941 2144725 PK04_098040 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccccc4OCCO)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NC[C@H](O)c7ccccc7)c8ccccc18 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 B21 compound treatment 412130.0 -57700.0 -0.29 244580.0 -167000.0 -0.78 -0.7584 -0.9074 2143413 PK04_098041 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(OCCO)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCN(CC7)c8ncccn8)c9cc(C#CC%10(O)CCCCCC%10)ccc19 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 B22 compound treatment 342330.0 -127000.0 -0.64 337620.0 -73800.0 -0.35 -0.6955 -0.9593 2141509 PK04_098042 COc1ccc(C#Cc2ccc3NC(=O)[C@]4([C@@H]([C@@H]5N([C@@H]4c6ccc(OCCO)cc6)[C@H]([C@H](OC5=O)c7ccccc7)c8ccccc8)C(=O)N9CCN(CC9)c%10ncccn%10)c3c2)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 B23 compound treatment 375040.0 -94700.0 -0.47 308480.0 -103000.0 -0.48 -0.6769 -0.9999 2142009 PK04_098043 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(OCCO)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)Nc7nc8ccccc8s7)c9cc(C#CCNC(=O)N)ccc19 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 B24 compound treatment 474040.0 4260.0 0.02 292510.0 -119000.0 -0.56 -0.3804 -0.6797 2141342 PK04_098044 NC(=O)NCC#Cc1ccc2NC(=O)[C@@]3([C@H]([C@H]4N([C@H]3c5ccccc5OCCO)[C@@H]([C@@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)N)c2c1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 C01 compound treatment 482720.0 12900.0 0.06 398290.0 -13100.0 -0.06 0.0021 0.0237 2141145 PK04_098045 OC(=O)[C@@H]1[C@@H]2N([C@H](c3ccc(O)cc3)[C@@]14C(=O)Nc5ccc(C#CC6(O)CCCCCC6)cc54)[C@H]([C@H](OC2=O)c7ccccc7)c8ccccc8 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 C02 compound treatment 274110.0 -196000.0 -0.98 287010.0 -124000.0 -0.59 -1.1047 -0.9699 2143097 PK04_098046 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(O)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCc8cc(OC)c(OC)cc8C7)c9cc(C#CC%10(O)CCCCCC%10)ccc19 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 C03 compound treatment 133250.0 -337000.0 -1.68 168770.0 -243000.0 -1.14 -1.9955 -0.9822 2141834 PK04_098047 Oc1ccc(cc1)[C@H]2N3[C@@H]([C@@H](C(=O)N4CCCCCCC4)[C@]25C(=O)Nc6ccc(C#CC7=CCCCC7)cc65)C(=O)O[C@@H]([C@@H]3c8ccccc8)c9ccccc9 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 C04 compound treatment 156840.0 -313000.0 -1.56 124220.0 -287000.0 -1.35 -2.0603 -0.9974 2142605 PK04_098048 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccccc4OCCO)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N)c7cc(C#Cc8ccc(OC)cc8)ccc17 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 C05 compound treatment 201760.0 -268000.0 -1.34 153350.0 -258000.0 -1.21 -1.8048 -0.9988 2141398 PK04_098049 OCCOc1ccccc1[C@@H]2N3[C@H]([C@H](C(=O)Nc4nc5ccccc5s4)[C@@]26C(=O)Nc7ccc(C#CC8=CCCCC8)cc76)C(=O)O[C@H]([C@H]3c9ccccc9)c%10ccccc%10 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 C06 compound treatment 316000.0 -154000.0 -0.77 215320.0 -196000.0 -0.92 -1.1952 -0.9959 2143013 PK04_098050 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(O)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCN(CC7)c8ncccn8)c9cc(C#CCCO)ccc19 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 C07 compound treatment 495380.0 25600.0 0.13 279680.0 -132000.0 -0.62 -0.3477 -0.5496 2141793 PK04_098051 NC(=O)[C@@H]1[C@@H]2N([C@H](c3ccc(O)cc3)[C@@]14C(=O)Nc5ccc(C#CCCO)cc54)[C@H]([C@H](OC2=O)c6ccccc6)c7ccccc7 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 C08 compound treatment 360770.0 -109000.0 -0.54 304340.0 -107000.0 -0.5 -0.741 -0.9992 2143277 PK04_098052 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(OCCO)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NC[C@H](O)c7ccccc7)c8cc(C#CCNC(=O)N)ccc18 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 C09 compound treatment 196800.0 -273000.0 -1.36 125810.0 -286000.0 -1.34 -1.9139 -1.0 2141681 PK04_098053 COc1ccc(C#Cc2ccc3NC(=O)[C@]4([C@@H]([C@@H]5N([C@@H]4c6ccccc6OCCO)[C@H]([C@H](OC5=O)c7ccccc7)c8ccccc8)C(=O)NC[C@H](O)c9ccccc9)c3c2)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 C10 compound treatment 135300.0 -334000.0 -1.67 126510.0 -285000.0 -1.34 -2.1288 -0.994 2144125 PK04_098054 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccccc4OCCO)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N)c7cc(C#CC8=CCCCC8)ccc17 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 C11 mock treatment 429980.0 -39800.0 -0.2 431520.0 20100.0 0.09 -0.0736 -0.3343 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 C12 mock treatment 377650.0 -92100.0 -0.46 407430.0 -3960.0 -0.02 -0.3386 -0.7351 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 C13 compound treatment 167200.0 -303000.0 -1.51 125280.0 -286000.0 -1.35 -2.0202 -0.9983 2141376 PK04_098055 OCCOc1ccccc1[C@@H]2N3[C@H]([C@H](C(=O)Nc4nc5ccccc5s4)[C@@]26C(=O)Nc7ccc(C#CC8(O)CCCCCC8)cc76)C(=O)O[C@H]([C@H]3c9ccccc9)c%10ccccc%10 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 C14 compound treatment 412520.0 -57300.0 -0.29 289570.0 -122000.0 -0.57 -0.6074 -0.9485 2143897 PK04_098056 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccccc4OCCO)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCc8cc(OC)c(OC)cc8C7)c9cc(C#Cc%10ccc(OC)cc%10)ccc19 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 C15 mock treatment 470290.0 505.0 0.0 374560.0 -36800.0 -0.17 -0.1207 -0.6967 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 C16 mock treatment 472380.0 2600.0 0.01 431260.0 19900.0 0.09 0.0753 0.7975 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 C17 compound treatment 298560.0 -171000.0 -0.86 296350.0 -115000.0 -0.54 -0.9873 -0.9756 2141461 PK04_098057 O[C@@H](CNC(=O)[C@H]1[C@H]2N([C@@H](c3ccc(O)cc3)[C@]14C(=O)Nc5ccc(C#CC6(O)CCCCCC6)cc54)[C@@H]([C@@H](OC2=O)c7ccccc7)c8ccccc8)c9ccccc9 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 C18 compound treatment 408720.0 -61100.0 -0.3 321760.0 -89600.0 -0.42 -0.5138 -0.9874 2143145 PK04_098058 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(O)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NCC=C)c7cc(C#CC8=CCCCC8)ccc17 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 C19 compound treatment 180980.0 -289000.0 -1.44 150910.0 -260000.0 -1.23 -1.8863 -0.9967 2141551 PK04_098059 NC(=O)[C@@H]1[C@@H]2N([C@H](c3ccc(OCCO)cc3)[C@@]14C(=O)Nc5ccc(C#CC6(O)CCCCCC6)cc54)[C@H]([C@H](OC2=O)c7ccccc7)c8ccccc8 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 C20 compound treatment 185180.0 -285000.0 -1.42 260380.0 -151000.0 -0.71 -1.5074 -0.9486 2144941 PK04_098060 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(O)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCN(CC7)c8ncccn8)c9ccccc19 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 C21 compound treatment 279330.0 -190000.0 -0.95 202020.0 -209000.0 -0.98 -1.369 -0.9998 2141535 PK04_098061 COC(=O)C(CC#Cc1ccc2NC(=O)[C@]3([C@@H]([C@@H]4N([C@@H]3c5ccc(OCCO)cc5)[C@H]([C@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)NCC=C)c2c1)C(=O)OC 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 C22 compound treatment 213490.0 -256000.0 -1.28 265210.0 -146000.0 -0.69 -1.3913 -0.9575 2142185 PK04_098062 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(OCCO)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NCC=C)c7cc(C#CC8=CCCCC8)ccc17 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 C23 compound treatment 440570.0 -29200.0 -0.15 342400.0 -69000.0 -0.32 -0.3326 -0.9349 2141425 PK04_098063 NC(=O)NCC#Cc1ccc2NC(=O)[C@@]3([C@H]([C@H]4N([C@H]3c5ccc(O)cc5)[C@@H]([C@@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)NCC=C)c2c1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 C24 compound treatment 338880.0 -131000.0 -0.65 289660.0 -122000.0 -0.57 -0.8672 -0.9978 2144353 PK04_098064 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(O)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCCCCCC7)c8cc(C#CC9(O)CCCCCC9)ccc18 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 D01 compound treatment 378440.0 -91300.0 -0.46 277440.0 -134000.0 -0.63 -0.7681 -0.9874 2143317 PK04_098065 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(OCCO)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NC[C@H](O)c7ccccc7)c8cc(C#CCCO)ccc18 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 D02 compound treatment 161570.0 -308000.0 -1.54 162790.0 -249000.0 -1.17 -1.9153 -0.9908 2144805 PK04_098066 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(OCCO)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NC[C@H](O)c7ccccc7)c8ccccc18 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 D03 compound treatment 490880.0 21100.0 0.11 199140.0 -212000.0 -1.0 -0.6314 -0.629 2142937 PK04_098067 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(O)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCc8cc(OC)c(OC)cc8C7)c9cc(C#Cc%10ccc(OC)cc%10)ccc19 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 D04 compound treatment 262950.0 -207000.0 -1.03 281640.0 -130000.0 -0.61 -1.162 -0.9685 2141997 PK04_098068 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(OCCO)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NC[C@H](O)c7ccccc7)c8cc(C#CCNC(=O)N)ccc18 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 D05 compound treatment 411590.0 -58200.0 -0.29 186370.0 -225000.0 -1.06 -0.9539 -0.8691 2144781 PK04_098069 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(O)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCN(CC7)c8ncccn8)c9ccccc19 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 D06 compound treatment 130470.0 -339000.0 -1.69 188290.0 -223000.0 -1.05 -1.9404 -0.9734 2144025 PK04_098070 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccccc4OCCO)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NCC=C)c7cc(C#CC8(O)CCCCCC8)ccc17 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 D07 compound treatment 201600.0 -268000.0 -1.34 171740.0 -240000.0 -1.13 -1.7442 -0.9963 2144817 PK04_098071 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(OCCO)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)Nc7nc8ccccc8s7)c9ccccc19 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 D08 compound treatment 518310.0 48500.0 0.24 241560.0 -170000.0 -0.8 -0.3935 -0.4714 2144197 PK04_098072 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(O)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NC[C@H](O)c7ccccc7)c8cc(C#Cc9ccc(OC)cc9)ccc18 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 D09 compound treatment 275640.0 -194000.0 -0.97 311240.0 -100000.0 -0.47 -1.0187 -0.945 2144761 PK04_098073 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(O)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCCCCCC7)c8ccccc18 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 D10 compound treatment 126740.0 -343000.0 -1.71 133350.0 -278000.0 -1.31 -2.1363 -0.9911 2142125 PK04_098074 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(OCCO)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N)c7cc(C#CC8(O)CCCCCC8)ccc17 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 D11 mock treatment 375740.0 -94000.0 -0.47 502500.0 91100.0 0.43 -0.0291 -0.0458 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 D12 mock treatment 470680.0 895.0 0.0 483710.0 72300.0 0.34 0.2437 0.7163 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 D13 compound treatment 251440.0 -218000.0 -1.09 243490.0 -168000.0 -0.79 -1.3295 -0.9874 2143225 PK04_098075 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(OCCO)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NCC=C)c7cc(C#Cc8ccc(OC)cc8)ccc17 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 D14 compound treatment 484650.0 14900.0 0.07 420990.0 9600.0 0.05 0.0844 0.9716 2144233 PK04_098076 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(O)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCCCCCC7)c8cc(C#CCNC(=O)N)ccc18 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 D15 mock treatment 502510.0 32700.0 0.16 528060.0 117000.0 0.55 0.5036 0.8795 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 D16 mock treatment 545280.0 75500.0 0.38 488110.0 76700.0 0.36 0.5218 0.9998 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 D17 compound treatment 449920.0 -19900.0 -0.1 427880.0 16500.0 0.08 -0.0153 -0.1215 2143045 PK04_098077 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(O)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N)c7cc(C#CCC(C(=O)OC)C(=O)OC)ccc17 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 D18 compound treatment 318100.0 -152000.0 -0.76 466650.0 55300.0 0.26 -0.3519 -0.4394 2142013 PK04_098078 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(OCCO)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCN(CC7)c8ncccn8)c9cc(C#CCNC(=O)N)ccc19 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 D19 compound treatment 448070.0 -21700.0 -0.11 274900.0 -136000.0 -0.64 -0.5306 -0.815 2142213 PK04_098079 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(OCCO)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCN(CC7)c8ncccn8)c9cc(C#CC%10=CCCCC%10)ccc19 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 D20 compound treatment 369220.0 -101000.0 -0.5 450680.0 39300.0 0.18 -0.2245 -0.4194 2141447 PK04_098080 COC(=O)C(CC#Cc1ccc2NC(=O)[C@@]3([C@H]([C@H]4N([C@H]3c5ccc(O)cc5)[C@@H]([C@@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)NCC=C)c2c1)C(=O)OC 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 D21 compound treatment 242720.0 -227000.0 -1.13 235590.0 -176000.0 -0.83 -1.3866 -0.988 2143393 PK04_098081 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(OCCO)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCCCCCC7)c8cc(C#CC9(O)CCCCCC9)ccc18 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 D22 compound treatment 385880.0 -83900.0 -0.42 458460.0 47100.0 0.22 -0.1398 -0.2949 2065844 PK04_098082 OCCOc1ccc(cc1)[C@H]2N3[C@@H]([C@@H](C(=O)O)[C@]24C(=O)Nc5ccc(C#CCCO)cc54)C(=O)O[C@@H]([C@@H]3c6ccccc6)c7ccccc7 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 D23 compound treatment 274640.0 -195000.0 -0.97 231420.0 -180000.0 -0.85 -1.2878 -0.9975 2144185 PK04_098083 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(O)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NCC=C)c7cc(C#Cc8ccc(OC)cc8)ccc17 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 D24 compound treatment 312030.0 -158000.0 -0.79 232280.0 -179000.0 -0.84 -1.1528 -0.9994 2141197 PK04_098084 OCCOc1ccc(cc1)[C@@H]2N3[C@H]([C@H](C(=O)NC[C@H](O)c4ccccc4)[C@@]25C(=O)Nc6ccc(C#CC7(O)CCCCCC7)cc65)C(=O)O[C@H]([C@H]3c8ccccc8)c9ccccc9 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 E01 mock treatment 541150.0 71400.0 0.36 489460.0 78100.0 0.37 0.5117 0.9999 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 E02 mock treatment 501730.0 31900.0 0.16 488810.0 77400.0 0.36 0.3703 0.9314 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 E03 compound treatment 179360.0 -290000.0 -1.45 224160.0 -187000.0 -0.88 -1.6484 -0.9714 2141526 PK04_098085 OCCOc1ccc(cc1)[C@H]2N3[C@@H]([C@@H](C(=O)N4CCCCCCC4)[C@]25C(=O)Nc6ccc(C#CCCO)cc65)C(=O)O[C@@H]([C@@H]3c7ccccc7)c8ccccc8 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 E04 compound treatment 497840.0 28100.0 0.14 210880.0 -201000.0 -0.94 -0.5678 -0.5955 2142637 PK04_098086 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccccc4OCCO)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NC[C@H](O)c7ccccc7)c8cc(C#CCNC(=O)N)ccc18 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 E05 compound treatment 456670.0 -13100.0 -0.07 332440.0 -78900.0 -0.37 -0.3089 -0.8192 2141181 PK04_098087 COc1cc2CCN(Cc2cc1OC)C(=O)[C@H]3[C@H]4N([C@@H](c5ccc(OCCO)cc5)[C@]36C(=O)Nc7ccc(C#CCCO)cc76)[C@@H]([C@@H](OC4=O)c8ccccc8)c9ccccc9 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 E06 compound treatment 205960.0 -264000.0 -1.32 259580.0 -152000.0 -0.71 -1.4367 -0.9586 2142777 PK04_098088 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccccc4OCCO)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCc8cc(OC)c(OC)cc8C7)c9cc(C#CC%10(O)CCCCCC%10)ccc19 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 E07 compound treatment 505340.0 35600.0 0.18 450480.0 39100.0 0.18 0.2556 0.9998 2141090 PK04_098089 OC(=O)[C@@H]1[C@@H]2N([C@H](c3ccc(O)cc3)[C@@]14C(=O)Nc5ccccc54)[C@H]([C@H](OC2=O)c6ccccc6)c7ccccc7 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 E08 compound treatment 180410.0 -289000.0 -1.45 241290.0 -170000.0 -0.8 -1.5877 -0.9611 2144801 PK04_098090 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(OCCO)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCCCCCC7)c8ccccc18 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 E09 mock treatment 322800.0 -147000.0 -0.73 424860.0 13500.0 0.06 -0.4743 -0.6437 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 E10 mock treatment 512240.0 42500.0 0.21 437800.0 26400.0 0.12 0.2378 0.9676 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 E11 compound treatment 334630.0 -135000.0 -0.68 270650.0 -141000.0 -0.66 -0.9454 -1.0 2141328 PK04_098091 COc1ccc(C#Cc2ccc3NC(=O)[C@@]4([C@H]([C@H]5N([C@H]4c6ccccc6OCCO)[C@@H]([C@@H](OC5=O)c7ccccc7)c8ccccc8)C(=O)N9CCCCCCC9)c3c2)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 E12 compound treatment 110810.0 -359000.0 -1.79 104330.0 -307000.0 -1.44 -2.289 -0.9943 2144117 PK04_098092 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccccc4OCCO)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NC[C@H](O)c7ccccc7)c8cc(C#CC9=CCCCC9)ccc18 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 E13 compound treatment 238280.0 -232000.0 -1.16 205040.0 -206000.0 -0.97 -1.5039 -0.9962 2141750 PK04_098093 OCCOc1ccccc1[C@H]2N3[C@@H]([C@@H](C(=O)Nc4nc5ccccc5s4)[C@]26C(=O)Nc7ccc(C#CC8=CCCCC8)cc76)C(=O)O[C@@H]([C@@H]3c9ccccc9)c%10ccccc%10 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 E14 compound treatment 367200.0 -103000.0 -0.51 370400.0 -41000.0 -0.19 -0.4986 -0.9108 2142133 PK04_098094 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(OCCO)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCN(CC7)c8ncccn8)c9cc(C#CC%10(O)CCCCCC%10)ccc19 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 E15 compound treatment 308020.0 -162000.0 -0.81 263230.0 -148000.0 -0.7 -1.0641 -0.9973 2141837 PK04_098095 NC(=O)[C@@H]1[C@@H]2N([C@H](c3ccc(O)cc3)[C@@]14C(=O)Nc5ccc(C#CC6=CCCCC6)cc54)[C@H]([C@H](OC2=O)c7ccccc7)c8ccccc8 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 E16 compound treatment 260970.0 -209000.0 -1.04 292930.0 -118000.0 -0.56 -1.1315 -0.9569 2143333 PK04_098096 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(OCCO)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCN(CC7)c8ncccn8)c9cc(C#CCCO)ccc19 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 E17 mock treatment 489850.0 20100.0 0.1 493850.0 82500.0 0.39 0.3451 0.8615 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 E18 mock treatment 498100.0 28300.0 0.14 539240.0 128000.0 0.6 0.5252 0.8502 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 E19 compound treatment 191710.0 -278000.0 -1.39 213610.0 -198000.0 -0.93 -1.6399 -0.981 2141392 PK04_098097 OCCOc1ccccc1[C@@H]2N3[C@H]([C@H](C(=O)NCC=C)[C@@]24C(=O)Nc5ccc(C#CC6=CCCCC6)cc54)C(=O)O[C@H]([C@H]3c7ccccc7)c8ccccc8 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 E20 compound treatment 279720.0 -190000.0 -0.95 331230.0 -80200.0 -0.38 -0.9379 -0.9182 2144457 PK04_098098 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(O)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCc8cc(OC)c(OC)cc8C7)c9cc(C#CC%10=CCCCC%10)ccc19 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 E21 compound treatment 448660.0 -21100.0 -0.11 415710.0 4320.0 0.02 -0.0602 -0.5606 2141783 PK04_098099 NC(=O)NCC#Cc1ccc2NC(=O)[C@]3([C@@H]([C@@H]4N([C@@H]3c5ccc(O)cc5)[C@H]([C@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)Nc8nc9ccccc9s8)c2c1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 E22 compound treatment 261650.0 -208000.0 -1.04 278020.0 -133000.0 -0.63 -1.1786 -0.9708 2142073 PK04_098100 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(OCCO)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCCCCCC7)c8cc(C#CCC(C(=O)OC)C(=O)OC)ccc18 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 E23 compound treatment 195230.0 -275000.0 -1.37 206570.0 -205000.0 -0.96 -1.6509 -0.9851 2141929 PK04_098101 COc1cc2CCN(Cc2cc1OC)C(=O)[C@@H]3[C@@H]4N([C@H](c5ccccc5OCCO)[C@@]36C(=O)Nc7ccccc76)[C@H]([C@H](OC4=O)c8ccccc8)c9ccccc9 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 E24 compound treatment 318320.0 -151000.0 -0.76 391850.0 -19500.0 -0.09 -0.5999 -0.7872 2141993 PK04_098102 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(OCCO)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCCCCCC7)c8cc(C#CCNC(=O)N)ccc18 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 F01 mock treatment 520020.0 50200.0 0.25 502890.0 91500.0 0.43 0.4817 0.967 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 F02 mock treatment 513020.0 43200.0 0.22 500320.0 88900.0 0.42 0.4485 0.9527 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 F03 compound treatment 186450.0 -283000.0 -1.42 387520.0 -23900.0 -0.11 -1.08 -0.7608 2142917 PK04_098103 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(O)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NC[C@H](O)c7ccccc7)c8cc(C#Cc9ccc(OC)cc9)ccc18 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 F04 compound treatment 499680.0 29900.0 0.15 492250.0 80900.0 0.38 0.3745 0.9166 2142953 PK04_098104 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(O)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCCCCCC7)c8cc(C#CCNC(=O)N)ccc18 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 F05 compound treatment 322020.0 -148000.0 -0.74 156000.0 -255000.0 -1.2 -1.3713 -0.9726 2144897 PK04_098105 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccccc4OCCO)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)Nc7nc8ccccc8s7)c9ccccc19 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 F06 compound treatment 353020.0 -117000.0 -0.58 323200.0 -88200.0 -0.41 -0.7057 -0.9861 2144329 PK04_098106 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(O)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)Nc7nc8ccccc8s7)c9cc(C#CCC(C(=O)OC)C(=O)OC)ccc19 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 F07 compound treatment 211720.0 -258000.0 -1.29 176660.0 -235000.0 -1.1 -1.6921 -0.997 2144721 PK04_098107 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccccc4OCCO)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCCCCCC7)c8ccccc18 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 F08 compound treatment 211470.0 -258000.0 -1.29 260640.0 -151000.0 -0.71 -1.4137 -0.9603 2143969 PK04_098108 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccccc4OCCO)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)Nc7nc8ccccc8s7)c9cc(C#CCCO)ccc19 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 F09 mock treatment 540860.0 71100.0 0.35 316210.0 -95200.0 -0.45 -0.0656 -0.1147 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 F10 mock treatment 243730.0 -226000.0 -1.13 510100.0 98700.0 0.46 -0.47 -0.385 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 F11 compound treatment 270370.0 -199000.0 -1.0 306080.0 -105000.0 -0.5 -1.0545 -0.948 2141973 PK04_098109 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(OCCO)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCN(CC7)c8ncccn8)c9cc(C#Cc%10ccc(OC)cc%10)ccc19 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 F12 compound treatment 219150.0 -251000.0 -1.25 466920.0 55500.0 0.26 -0.7005 -0.5478 2141515 PK04_098110 NC(=O)NCC#Cc1ccc2NC(=O)[C@]3([C@@H]([C@@H]4N([C@@H]3c5ccc(OCCO)cc5)[C@H]([C@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)N8CCCCCCC8)c2c1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 F13 compound treatment 405440.0 -64300.0 -0.32 226350.0 -185000.0 -0.87 -0.8427 -0.9083 2144053 PK04_098111 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccccc4OCCO)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCN(CC7)c8ncccn8)c9cc(C#CC%10(O)CCCCCC%10)ccc19 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 F14 compound treatment 486240.0 16500.0 0.08 245600.0 -166000.0 -0.78 -0.4933 -0.6291 2143249 PK04_098112 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(OCCO)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)Nc7nc8ccccc8s7)c9cc(C#Cc%10ccc(OC)cc%10)ccc19 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 F15 compound treatment 214660.0 -255000.0 -1.27 219940.0 -191000.0 -0.9 -1.5378 -0.9856 2144873 PK04_098113 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccccc4OCCO)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NCC=C)c7ccccc17 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 F16 compound treatment 353600.0 -116000.0 -0.58 259000.0 -152000.0 -0.72 -0.9172 -0.9945 2141199 PK04_098114 NC(=O)[C@H]1[C@H]2N([C@@H](c3ccc(OCCO)cc3)[C@]14C(=O)Nc5ccc(C#CC6(O)CCCCCC6)cc54)[C@@H]([C@@H](OC2=O)c7ccccc7)c8ccccc8 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 F17 mock treatment 508530.0 38700.0 0.19 261760.0 -150000.0 -0.7 -0.3608 -0.4943 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 F18 mock treatment 495800.0 26000.0 0.13 376400.0 -35000.0 -0.16 -0.0245 -0.1168 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 F19 compound treatment 266990.0 -203000.0 -1.01 247620.0 -164000.0 -0.77 -1.2609 -0.9909 2142825 PK04_098115 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccccc4OCCO)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NCC=C)c7cc(C#CC8=CCCCC8)ccc17 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 F20 compound treatment 365300.0 -104000.0 -0.52 416840.0 5450.0 0.03 -0.3509 -0.6716 2144217 PK04_098116 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(O)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCc8cc(OC)c(OC)cc8C7)c9cc(C#Cc%10ccc(OC)cc%10)ccc19 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 F21 compound treatment 347480.0 -122000.0 -0.61 269290.0 -142000.0 -0.67 -0.9046 -0.999 2144057 PK04_098117 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccccc4OCCO)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCc8cc(OC)c(OC)cc8C7)c9cc(C#CC%10(O)CCCCCC%10)ccc19 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 F22 compound treatment 496000.0 26200.0 0.13 332090.0 -79300.0 -0.37 -0.1712 -0.433 2141689 PK04_098118 NC(=O)NCC#Cc1ccc2NC(=O)[C@]3([C@@H]([C@@H]4N([C@@H]3c5ccccc5OCCO)[C@H]([C@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)NCC=C)c2c1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 F23 compound treatment 119380.0 -350000.0 -1.75 143730.0 -268000.0 -1.26 -2.1277 -0.9869 2144037 PK04_098119 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccccc4OCCO)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NC[C@H](O)c7ccccc7)c8cc(C#CC9(O)CCCCCC9)ccc18 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 F24 compound treatment 434300.0 -35500.0 -0.18 521530.0 110000.0 0.52 0.241 0.4402 2141464 PK04_098120 Oc1ccc(cc1)[C@@H]2N3[C@H]([C@H](C(=O)Nc4nc5ccccc5s4)[C@@]26C(=O)Nc7ccc(C#CC8(O)CCCCCC8)cc76)C(=O)O[C@H]([C@H]3c9ccccc9)c%10ccccc%10 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 G01 compound treatment 66080.0 -404000.0 -2.02 79840.0 -332000.0 -1.56 -2.5285 -0.9919 2141573 PK04_098121 NC(=O)[C@@H]1[C@@H]2N([C@H](c3ccc(OCCO)cc3)[C@@]14C(=O)Nc5ccc(C#CC6=CCCCC6)cc54)[C@H]([C@H](OC2=O)c7ccccc7)c8ccccc8 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 G02 compound treatment 398810.0 -71000.0 -0.35 206320.0 -205000.0 -0.96 -0.9327 -0.9076 2144113 PK04_098122 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccccc4OCCO)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCCCCCC7)c8cc(C#CC9=CCCCC9)ccc18 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 G03 mock treatment 546400.0 76600.0 0.38 519680.0 108000.0 0.51 0.6308 0.9901 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 G04 mock treatment 522840.0 53100.0 0.26 502990.0 91600.0 0.43 0.492 0.9727 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 G05 compound treatment 426570.0 -43200.0 -0.22 216410.0 -195000.0 -0.92 -0.8011 -0.8503 2141531 PK04_098123 OCCOc1ccc(cc1)[C@H]2N3[C@@H]([C@@H](C(=O)N4CCN(CC4)c5ncccn5)[C@]26C(=O)Nc7ccc(C#CCCO)cc76)C(=O)O[C@@H]([C@@H]3c8ccccc8)c9ccccc9 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 G06 compound treatment 63840.0 -406000.0 -2.03 29470.0 -382000.0 -1.8 -2.7039 -0.9982 2143985 PK04_098124 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccccc4OCCO)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NCC=C)c7cc(C#CCC(C(=O)OC)C(=O)OC)ccc17 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 G07 compound treatment 178720.0 -291000.0 -1.45 201920.0 -209000.0 -0.99 -1.7246 -0.982 2065843 PK04_098125 OCCOc1ccc(cc1)[C@H]2N3[C@@H]([C@@H](C(=O)O)[C@]24C(=O)Nc5ccc(C#CC6=CCCCC6)cc54)C(=O)O[C@@H]([C@@H]3c7ccccc7)c8ccccc8 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 G08 compound treatment 135710.0 -334000.0 -1.67 179920.0 -231000.0 -1.09 -1.9497 -0.9786 2144713 PK04_098126 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccccc4OCCO)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NCC=C)c7ccccc17 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 G09 compound treatment 442330.0 -27500.0 -0.14 173610.0 -238000.0 -1.12 -0.8878 -0.7879 2141779 PK04_098127 NC(=O)NCC#Cc1ccc2NC(=O)[C@]3([C@@H]([C@@H]4N([C@@H]3c5ccc(O)cc5)[C@H]([C@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)N8CCCCCCC8)c2c1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 G10 compound treatment 315400.0 -154000.0 -0.77 361970.0 -49400.0 -0.23 -0.7096 -0.8811 2142633 PK04_098128 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccccc4OCCO)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCCCCCC7)c8cc(C#CCNC(=O)N)ccc18 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 G11 compound treatment 41680.0 -428000.0 -2.14 40320.0 -371000.0 -1.75 -2.7461 -0.9949 2141711 PK04_098129 COC(=O)C(CC#Cc1ccc2NC(=O)[C@]3([C@@H]([C@@H]4N([C@@H]3c5ccccc5OCCO)[C@H]([C@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)NCC=C)c2c1)C(=O)OC 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 G12 compound treatment 186620.0 -283000.0 -1.41 206400.0 -205000.0 -0.96 -1.6818 -0.9826 2142689 PK04_098130 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccccc4OCCO)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)Nc7nc8ccccc8s7)c9cc(C#CCCO)ccc19 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 G13 compound treatment 525790.0 56000.0 0.28 470430.0 59000.0 0.28 0.3942 1.0 2141802 PK04_098131 COC(=O)C(CC#Cc1ccc2NC(=O)[C@]3([C@@H]([C@@H]4N([C@@H]3c5ccc(O)cc5)[C@H]([C@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)NC[C@H](O)c8ccccc8)c2c1)C(=O)OC 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 G14 compound treatment 439680.0 -30100.0 -0.15 497950.0 86600.0 0.41 0.1816 0.4184 2142905 PK04_098132 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(O)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NCC=C)c7cc(C#Cc8ccc(OC)cc8)ccc17 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 G15 compound treatment 309440.0 -160000.0 -0.8 345620.0 -65800.0 -0.31 -0.785 -0.9144 2141192 PK04_098133 COC(=O)C(CC#Cc1ccc2NC(=O)[C@@]3([C@H]([C@H]4N([C@H]3c5ccc(OCCO)cc5)[C@@H]([C@@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)N8CCc9cc(OC)c(OC)cc9C8)c2c1)C(=O)OC 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 G16 compound treatment 433370.0 -36400.0 -0.18 199930.0 -211000.0 -0.99 -0.8319 -0.8228 2142129 PK04_098134 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(OCCO)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)Nc7nc8ccccc8s7)c9cc(C#CC%10(O)CCCCCC%10)ccc19 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 G17 compound treatment 225480.0 -244000.0 -1.22 145920.0 -265000.0 -1.25 -1.7457 -0.9999 2141728 PK04_098135 OCCOc1ccccc1[C@H]2N3[C@@H]([C@@H](C(=O)Nc4nc5ccccc5s4)[C@]26C(=O)Nc7ccc(C#CC8(O)CCCCCC8)cc76)C(=O)O[C@@H]([C@@H]3c9ccccc9)c%10ccccc%10 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 G18 compound treatment 258560.0 -211000.0 -1.05 317160.0 -94200.0 -0.44 -1.0594 -0.9258 2144641 PK04_098136 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(OCCO)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCCCCCC7)c8ccccc18 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 G19 mock treatment 464650.0 -5130.0 -0.03 483900.0 72500.0 0.34 0.223 0.6521 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 G20 mock treatment 414000.0 -55800.0 -0.28 501450.0 90100.0 0.42 0.1025 0.2022 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 G21 compound treatment 293870.0 -176000.0 -0.88 352230.0 -59200.0 -0.28 -0.818 -0.8876 2141885 PK04_098137 COc1cc2CCN(Cc2cc1OC)C(=O)[C@H]3[C@H]4N([C@@H](c5ccccc5OCCO)[C@]36C(=O)Nc7ccccc76)[C@@H]([C@@H](OC4=O)c8ccccc8)c9ccccc9 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 G22 compound treatment 320520.0 -149000.0 -0.75 460840.0 49500.0 0.23 -0.3627 -0.4644 2144357 PK04_098138 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(O)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NC[C@H](O)c7ccccc7)c8cc(C#CC9(O)CCCCCC9)ccc18 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 G23 compound treatment 391860.0 -77900.0 -0.39 290160.0 -121000.0 -0.57 -0.6784 -0.9827 2141361 PK04_098139 COC(=O)C(CC#Cc1ccc2NC(=O)[C@@]3([C@H]([C@H]4N([C@H]3c5ccccc5OCCO)[C@@H]([C@@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)N8CCCCCCC8)c2c1)C(=O)OC 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 G24 compound treatment 469010.0 -775.0 0.0 423680.0 12300.0 0.06 0.0381 0.6583 2142625 PK04_098140 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccccc4OCCO)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NCC=C)c7cc(C#CCNC(=O)N)ccc17 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 H01 compound treatment 205380.0 -264000.0 -1.32 213440.0 -198000.0 -0.93 -1.5922 -0.9854 2142737 PK04_098141 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccccc4OCCO)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCc8cc(OC)c(OC)cc8C7)c9cc(C#CCC(C(=O)OC)C(=O)OC)ccc19 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 H02 compound treatment 371760.0 -98000.0 -0.49 315260.0 -96100.0 -0.45 -0.6659 -0.9992 2144017 PK04_098142 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccccc4OCCO)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCc8cc(OC)c(OC)cc8C7)c9cc(C#CCC(C(=O)OC)C(=O)OC)ccc19 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 H03 mock treatment 569390.0 99600.0 0.5 296800.0 -115000.0 -0.54 -0.0294 -0.04 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 H04 mock treatment 575060.0 105000.0 0.53 184280.0 -227000.0 -1.07 -0.3836 -0.3222 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 H05 compound treatment 361920.0 -108000.0 -0.54 419040.0 7650.0 0.04 -0.3555 -0.6584 2143493 PK04_098143 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(OCCO)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCN(CC7)c8ncccn8)c9cc(C#CC%10=CCCCC%10)ccc19 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 H06 compound treatment 243840.0 -226000.0 -1.13 279580.0 -132000.0 -0.62 -1.2364 -0.9602 2141857 PK04_098144 OCCOc1ccc(cc1)[C@@H]2N3[C@H]([C@H](C(=O)NC[C@H](O)c4ccccc4)[C@@]25C(=O)Nc6ccccc65)C(=O)O[C@H]([C@H]3c7ccccc7)c8ccccc8 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 H07 compound treatment 290400.0 -179000.0 -0.9 223330.0 -188000.0 -0.88 -1.259 -1.0 2143497 PK04_098145 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(OCCO)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCc8cc(OC)c(OC)cc8C7)c9cc(C#CC%10=CCCCC%10)ccc19 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 H08 compound treatment 483140.0 13400.0 0.07 466900.0 55500.0 0.26 0.2318 0.8601 2141183 PK04_098146 COC(=O)C(CC#Cc1ccc2NC(=O)[C@@]3([C@H]([C@H]4N([C@H]3c5ccc(OCCO)cc5)[C@@H]([C@@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)NCC=C)c2c1)C(=O)OC 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 H09 compound treatment 579710.0 110000.0 0.55 266280.0 -145000.0 -0.68 -0.0944 -0.1078 2143289 PK04_098147 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(OCCO)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)Nc7nc8ccccc8s7)c9cc(C#CCNC(=O)N)ccc19 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 H10 compound treatment 279960.0 -190000.0 -0.95 446720.0 35300.0 0.17 -0.5529 -0.5744 2142033 PK04_098148 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(OCCO)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCCCCCC7)c8cc(C#CCCO)ccc18 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 H11 compound treatment 236750.0 -233000.0 -1.16 206470.0 -205000.0 -0.96 -1.5046 -0.9956 2143345 PK04_098149 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(OCCO)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NCC=C)c7cc(C#CCC(C(=O)OC)C(=O)OC)ccc17 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 H12 compound treatment 325870.0 -144000.0 -0.72 318740.0 -92600.0 -0.44 -0.8164 -0.9713 2141965 PK04_098150 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(OCCO)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N)c7cc(C#Cc8ccc(OC)cc8)ccc17 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 H13 compound treatment 515370.0 45600.0 0.23 442790.0 31400.0 0.15 0.2654 0.978 2142053 PK04_098151 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(OCCO)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCN(CC7)c8ncccn8)c9cc(C#CCCO)ccc19 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 H14 compound treatment 437030.0 -32800.0 -0.16 567430.0 156000.0 0.73 0.4033 0.5363 2143285 PK04_098152 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(OCCO)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N)c7cc(C#CCNC(=O)N)ccc17 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 H15 compound treatment 322120.0 -148000.0 -0.74 323590.0 -87800.0 -0.41 -0.8135 -0.9624 2143953 PK04_098153 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccccc4OCCO)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCCCCCC7)c8cc(C#CCCO)ccc18 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 H16 compound treatment 279540.0 -190000.0 -0.95 211890.0 -199000.0 -0.94 -1.3354 -1.0 2142849 PK04_098154 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccccc4OCCO)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)Nc7nc8ccccc8s7)c9cc(C#CC%10=CCCCC%10)ccc19 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 H17 compound treatment 306840.0 -163000.0 -0.81 243360.0 -168000.0 -0.79 -1.1343 -0.9999 2142197 PK04_098155 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(OCCO)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NC[C@H](O)c7ccccc7)c8cc(C#CC9=CCCCC9)ccc18 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 H18 compound treatment 250240.0 -220000.0 -1.1 210200.0 -201000.0 -0.95 -1.4445 -0.9973 2141678 PK04_098156 COc1ccc(C#Cc2ccc3NC(=O)[C@]4([C@@H]([C@@H]5N([C@@H]4c6ccccc6OCCO)[C@H]([C@H](OC5=O)c7ccccc7)c8ccccc8)C(=O)NCC=C)c3c2)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 H19 mock treatment 541410.0 71600.0 0.36 473060.0 61700.0 0.29 0.4581 0.9946 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 H20 mock treatment 587090.0 117000.0 0.59 382140.0 -29200.0 -0.14 0.317 0.5267 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 H21 compound treatment 326130.0 -144000.0 -0.72 378030.0 -33400.0 -0.16 -0.6183 -0.8418 2142657 PK04_098157 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccccc4OCCO)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCc8cc(OC)c(OC)cc8C7)c9cc(C#CCNC(=O)N)ccc19 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 H22 compound treatment 342400.0 -127000.0 -0.64 237020.0 -174000.0 -0.82 -1.0298 -0.9921 2141194 PK04_098158 OCCOc1ccc(cc1)[C@@H]2N3[C@H]([C@H](C(=O)NCC=C)[C@@]24C(=O)Nc5ccc(C#CC6(O)CCCCCC6)cc54)C(=O)O[C@H]([C@H]3c7ccccc7)c8ccccc8 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 H23 compound treatment 248130.0 -222000.0 -1.11 208970.0 -202000.0 -0.95 -1.4561 -0.9972 2142665 PK04_098159 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccccc4OCCO)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NCC=C)c7cc(C#CCCO)ccc17 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 H24 compound treatment 487330.0 17500.0 0.09 254210.0 -157000.0 -0.74 -0.4608 -0.619 2141813 PK04_098160 O[C@@H](CNC(=O)[C@@H]1[C@@H]2N([C@H](c3ccc(O)cc3)[C@@]14C(=O)Nc5ccc(C#CC6(O)CCCCCC6)cc54)[C@H]([C@H](OC2=O)c7ccccc7)c8ccccc8)c9ccccc9 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 I01 compound treatment 101030.0 -369000.0 -1.84 143240.0 -268000.0 -1.26 -2.1942 -0.9829 2141395 PK04_098161 OCCOc1ccccc1[C@@H]2N3[C@H]([C@H](C(=O)NC[C@H](O)c4ccccc4)[C@@]25C(=O)Nc6ccc(C#CC7=CCCCC7)cc65)C(=O)O[C@H]([C@H]3c8ccccc8)c9ccccc9 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 I02 compound treatment 476220.0 6440.0 0.03 175960.0 -235000.0 -1.11 -0.7603 -0.6863 2144813 PK04_098162 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(OCCO)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N)c7ccccc17 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 I03 compound treatment 100240.0 -370000.0 -1.85 85670.0 -326000.0 -1.53 -2.3884 -0.9957 2141107 PK04_098163 COc1ccc(C#Cc2ccc3NC(=O)[C@@]4([C@H]([C@H]5N([C@H]4c6ccccc6OCCO)[C@@H]([C@@H](OC5=O)c7ccccc7)c8ccccc8)C(=O)O)c3c2)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 I04 compound treatment 320770.0 -149000.0 -0.74 301300.0 -110000.0 -0.52 -0.8924 -0.9843 2142597 PK04_098164 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccccc4OCCO)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NC[C@H](O)c7ccccc7)c8cc(C#Cc9ccc(OC)cc9)ccc18 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 I05 mock treatment 471380.0 1600.0 0.01 191430.0 -220000.0 -1.03 -0.7259 -0.7016 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 I06 mock treatment 522560.0 52800.0 0.26 237820.0 -174000.0 -0.82 -0.3909 -0.4557 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 I07 compound treatment 535060.0 65300.0 0.33 486400.0 75000.0 0.35 0.48 0.9992 2141144 PK04_098165 COC(=O)C(CC#Cc1ccc2NC(=O)[C@]3([C@@H]([C@@H]4N([C@@H]3c5ccc(O)cc5)[C@H]([C@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)O)c2c1)C(=O)OC 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 I08 compound treatment 264580.0 -205000.0 -1.02 313990.0 -97400.0 -0.46 -1.0487 -0.9341 2142693 PK04_098166 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccccc4OCCO)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCN(CC7)c8ncccn8)c9cc(C#CCCO)ccc19 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 I09 compound treatment 541230.0 71400.0 0.36 295580.0 -116000.0 -0.54 -0.1329 -0.204 2141896 PK04_098167 COc1cc2CCN(Cc2cc1OC)C(=O)[C@H]3[C@H]4N([C@@H](c5ccc(O)cc5)[C@]36C(=O)Nc7ccccc76)[C@@H]([C@@H](OC4=O)c8ccccc8)c9ccccc9 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 I10 compound treatment 215600.0 -254000.0 -1.27 184100.0 -227000.0 -1.07 -1.6537 -0.9963 2141957 PK04_098168 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(OCCO)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NC[C@H](O)c7ccccc7)c8cc(C#Cc9ccc(OC)cc9)ccc18 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 I11 compound treatment 408500.0 -61300.0 -0.31 122920.0 -288000.0 -1.36 -1.1759 -0.8454 2141394 PK04_098169 OCCOc1ccccc1[C@@H]2N3[C@H]([C@H](C(=O)N4CCCCCCC4)[C@@]25C(=O)Nc6ccc(C#CC7=CCCCC7)cc65)C(=O)O[C@H]([C@H]3c8ccccc8)c9ccccc9 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 I12 compound treatment 187040.0 -283000.0 -1.41 206530.0 -205000.0 -0.96 -1.6799 -0.9826 2142049 PK04_098170 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(OCCO)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)Nc7nc8ccccc8s7)c9cc(C#CCCO)ccc19 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 I13 compound treatment 529950.0 60200.0 0.3 366980.0 -44400.0 -0.21 0.0648 0.177 2141346 PK04_098171 COc1cc2CCN(Cc2cc1OC)C(=O)[C@H]3[C@H]4N([C@@H](c5ccccc5OCCO)[C@]36C(=O)Nc7ccc(C#CCNC(=O)N)cc76)[C@@H]([C@@H](OC4=O)c8ccccc8)c9ccccc9 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 I14 compound treatment 225810.0 -244000.0 -1.22 204440.0 -207000.0 -0.97 -1.5499 -0.9938 2143477 PK04_098172 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(OCCO)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NC[C@H](O)c7ccccc7)c8cc(C#CC9=CCCCC9)ccc18 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 I15 compound treatment 216160.0 -254000.0 -1.27 149200.0 -262000.0 -1.23 -1.7678 -0.9999 2141373 PK04_098173 OCCOc1ccccc1[C@@H]2N3[C@H]([C@H](C(=O)NC[C@H](O)c4ccccc4)[C@@]25C(=O)Nc6ccc(C#CC7(O)CCCCCC7)cc65)C(=O)O[C@H]([C@H]3c8ccccc8)c9ccccc9 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 I16 compound treatment 266590.0 -203000.0 -1.01 258760.0 -153000.0 -0.72 -1.2253 -0.9856 2144645 PK04_098174 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(OCCO)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NC[C@H](O)c7ccccc7)c8ccccc18 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 I17 compound treatment 304270.0 -166000.0 -0.83 325810.0 -85600.0 -0.4 -0.8692 -0.9453 2141116 PK04_098175 NC(=O)NCC#Cc1ccc2NC(=O)[C@@]3([C@H]([C@H]4N([C@H]3c5ccc(O)cc5)[C@@H]([C@@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)O)c2c1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 I18 compound treatment 300000.0 -170000.0 -0.85 265530.0 -146000.0 -0.69 -1.0847 -0.9945 2142097 PK04_098176 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(OCCO)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCc8cc(OC)c(OC)cc8C7)c9cc(C#CCC(C(=O)OC)C(=O)OC)ccc19 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 I19 compound treatment 473990.0 4210.0 0.02 450620.0 39200.0 0.18 0.1453 0.7825 2141442 PK04_098177 OCCC#Cc1ccc2NC(=O)[C@@]3([C@H]([C@H]4N([C@H]3c5ccc(O)cc5)[C@@H]([C@@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)Nc8nc9ccccc9s8)c2c1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 I20 compound treatment 529500.0 59700.0 0.3 334690.0 -76700.0 -0.36 -0.0442 -0.0944 2142005 PK04_098178 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(OCCO)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N)c7cc(C#CCNC(=O)N)ccc17 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 I21 mock treatment 551290.0 81500.0 0.41 317030.0 -94400.0 -0.44 -0.026 -0.0432 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 I22 mock treatment 563060.0 93300.0 0.47 490880.0 79500.0 0.37 0.5938 0.9941 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 I23 compound treatment 361380.0 -108000.0 -0.54 200000.0 -211000.0 -0.99 -1.0859 -0.9592 2141137 PK04_098179 OCCOc1ccccc1[C@H]2N3[C@@H]([C@@H](C(=O)O)[C@]24C(=O)Nc5ccc(C#CC6(O)CCCCCC6)cc54)C(=O)O[C@@H]([C@@H]3c7ccccc7)c8ccccc8 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 I24 compound treatment 218450.0 -251000.0 -1.26 253230.0 -158000.0 -0.74 -1.4137 -0.9688 2144905 PK04_098180 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccccc4OCCO)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCc8cc(OC)c(OC)cc8C7)c9ccccc19 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 J01 compound treatment 286910.0 -183000.0 -0.91 155690.0 -256000.0 -1.2 -1.4963 -0.9908 2142853 PK04_098181 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccccc4OCCO)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCN(CC7)c8ncccn8)c9cc(C#CC%10=CCCCC%10)ccc19 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 J02 compound treatment 173290.0 -296000.0 -1.48 305820.0 -106000.0 -0.5 -1.3982 -0.8952 2141434 PK04_098182 COc1cc2CCN(Cc2cc1OC)C(=O)[C@H]3[C@H]4N([C@@H](c5ccc(O)cc5)[C@]36C(=O)Nc7ccc(C#CCNC(=O)N)cc76)[C@@H]([C@@H](OC4=O)c8ccccc8)c9ccccc9 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 J03 compound treatment 205500.0 -264000.0 -1.32 187270.0 -224000.0 -1.05 -1.6788 -0.9938 2142925 PK04_098183 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(O)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N)c7cc(C#Cc8ccc(OC)cc8)ccc17 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 J04 compound treatment 204340.0 -265000.0 -1.33 193250.0 -218000.0 -1.03 -1.663 -0.992 2141810 PK04_098184 Oc1ccc(cc1)[C@H]2N3[C@@H]([C@@H](C(=O)NCC=C)[C@]24C(=O)Nc5ccc(C#CC6(O)CCCCCC6)cc54)C(=O)O[C@@H]([C@@H]3c7ccccc7)c8ccccc8 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 J05 mock treatment 161860.0 -308000.0 -1.54 205650.0 -206000.0 -0.97 -1.7718 -0.9751 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 J06 mock treatment 291200.0 -179000.0 -0.89 286490.0 -125000.0 -0.59 -1.0461 -0.9795 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 J07 compound treatment 362490.0 -107000.0 -0.54 278320.0 -133000.0 -0.63 -0.8215 -0.997 2143253 PK04_098185 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(OCCO)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCN(CC7)c8ncccn8)c9cc(C#Cc%10ccc(OC)cc%10)ccc19 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 J08 compound treatment 161980.0 -308000.0 -1.54 139410.0 -272000.0 -1.28 -1.9917 -0.9958 2141219 PK04_098186 OCCOc1ccc(cc1)[C@@H]2N3[C@H]([C@H](C(=O)NC[C@H](O)c4ccccc4)[C@@]25C(=O)Nc6ccc(C#CC7=CCCCC7)cc65)C(=O)O[C@H]([C@H]3c8ccccc8)c9ccccc9 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 J09 compound treatment 517460.0 47700.0 0.24 256000.0 -155000.0 -0.73 -0.3484 -0.4533 2142945 PK04_098187 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(O)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NCC=C)c7cc(C#CCNC(=O)N)ccc17 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 J10 compound treatment 190950.0 -279000.0 -1.39 497630.0 86200.0 0.41 -0.6979 -0.4811 2141450 PK04_098188 COC(=O)C(CC#Cc1ccc2NC(=O)[C@@]3([C@H]([C@H]4N([C@H]3c5ccc(O)cc5)[C@@H]([C@@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)NC[C@H](O)c8ccccc8)c2c1)C(=O)OC 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 J11 compound treatment 552260.0 82500.0 0.41 274560.0 -137000.0 -0.64 -0.1638 -0.2144 2144285 PK04_098189 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(O)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N)c7cc(C#CCCO)ccc17 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 J12 compound treatment 176750.0 -293000.0 -1.46 408580.0 -2810.0 -0.01 -1.0442 -0.7135 2141139 PK04_098190 OCCOc1ccccc1[C@H]2N3[C@@H]([C@@H](C(=O)O)[C@]24C(=O)Nc5ccc(C#CC6=CCCCC6)cc54)C(=O)O[C@@H]([C@@H]3c7ccccc7)c8ccccc8 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 J13 compound treatment 270570.0 -199000.0 -0.99 345130.0 -66300.0 -0.31 -0.9239 -0.8861 2143473 PK04_098191 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(OCCO)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCCCCCC7)c8cc(C#CC9=CCCCC9)ccc18 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 J14 compound treatment 228270.0 -242000.0 -1.21 304320.0 -107000.0 -0.5 -1.2091 -0.9249 2144013 PK04_098192 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccccc4OCCO)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCN(CC7)c8ncccn8)c9cc(C#CCC(C(=O)OC)C(=O)OC)ccc19 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 J15 compound treatment 212230.0 -258000.0 -1.29 191460.0 -220000.0 -1.03 -1.6411 -0.9942 2142837 PK04_098193 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccccc4OCCO)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NC[C@H](O)c7ccccc7)c8cc(C#CC9=CCCCC9)ccc18 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 J16 compound treatment 339040.0 -131000.0 -0.65 314440.0 -96900.0 -0.46 -0.7842 -0.9846 2141784 PK04_098194 NC(=O)NCC#Cc1ccc2NC(=O)[C@]3([C@@H]([C@@H]4N([C@@H]3c5ccc(O)cc5)[C@H]([C@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)N8CCN(CC8)c9ncccn9)c2c1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 J17 compound treatment 281960.0 -188000.0 -0.94 254880.0 -157000.0 -0.74 -1.1839 -0.9928 2144425 PK04_098195 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(O)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NCC=C)c7cc(C#CC8=CCCCC8)ccc17 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 J18 compound treatment 220070.0 -250000.0 -1.25 282490.0 -129000.0 -0.61 -1.3106 -0.9451 2141332 PK04_098196 COc1ccc(C#Cc2ccc3NC(=O)[C@@]4([C@H]([C@H]5N([C@H]4c6ccccc6OCCO)[C@@H]([C@@H](OC5=O)c7ccccc7)c8ccccc8)C(=O)Nc9nc%10ccccc%10s9)c3c2)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 J19 compound treatment 262930.0 -207000.0 -1.03 287690.0 -124000.0 -0.58 -1.142 -0.9631 2143957 PK04_098197 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccccc4OCCO)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NC[C@H](O)c7ccccc7)c8cc(C#CCCO)ccc18 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 J20 compound treatment 572160.0 102000.0 0.51 620710.0 209000.0 0.98 1.0578 0.9534 2141933 PK04_098198 Oc1ccc(cc1)[C@H]2N3[C@@H]([C@@H](C(=O)N4CCCCCCC4)[C@]25C(=O)Nc6ccccc65)C(=O)O[C@@H]([C@@H]3c7ccccc7)c8ccccc8 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 J21 mock treatment 439680.0 -30100.0 -0.15 487290.0 75900.0 0.36 0.1461 0.3772 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 J22 mock treatment 491400.0 21600.0 0.11 241200.0 -170000.0 -0.8 -0.4897 -0.6063 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 J23 compound treatment 246240.0 -224000.0 -1.12 143800.0 -268000.0 -1.26 -1.6795 -0.9982 2144049 PK04_098199 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccccc4OCCO)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)Nc7nc8ccccc8s7)c9cc(C#CC%10(O)CCCCCC%10)ccc19 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 J24 compound treatment 318080.0 -152000.0 -0.76 337760.0 -73600.0 -0.35 -0.7807 -0.9371 2141196 PK04_098200 OCCOc1ccc(cc1)[C@@H]2N3[C@H]([C@H](C(=O)N4CCCCCCC4)[C@@]25C(=O)Nc6ccc(C#CC7(O)CCCCCC7)cc65)C(=O)O[C@H]([C@H]3c8ccccc8)c9ccccc9 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 K01 compound treatment 507590.0 37800.0 0.19 248440.0 -163000.0 -0.77 -0.4085 -0.5174 2141522 PK04_098201 COc1cc2CCN(Cc2cc1OC)C(=O)[C@@H]3[C@@H]4N([C@H](c5ccc(OCCO)cc5)[C@@]36C(=O)Nc7ccc(C#CCNC(=O)N)cc76)[C@H]([C@H](OC4=O)c8ccccc8)c9ccccc9 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 K02 compound treatment 313020.0 -157000.0 -0.78 222190.0 -189000.0 -0.89 -1.1829 -0.998 2142617 PK04_098202 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccccc4OCCO)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCc8cc(OC)c(OC)cc8C7)c9cc(C#Cc%10ccc(OC)cc%10)ccc19 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 K03 compound treatment 531600.0 61800.0 0.31 153530.0 -258000.0 -1.21 -0.6393 -0.5108 2141439 PK04_098203 OCCC#Cc1ccc2NC(=O)[C@@]3([C@H]([C@H]4N([C@H]3c5ccc(O)cc5)[C@@H]([C@@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)NC[C@H](O)c8ccccc8)c2c1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 K04 compound treatment 502730.0 32900.0 0.16 181640.0 -230000.0 -1.08 -0.6478 -0.5926 2143329 PK04_098204 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(OCCO)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)Nc7nc8ccccc8s7)c9cc(C#CCCO)ccc19 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 K05 compound treatment 284090.0 -186000.0 -0.93 67880.0 -344000.0 -1.62 -1.7983 -0.9653 2141725 PK04_098205 OCCOc1ccccc1[C@H]2N3[C@@H]([C@@H](C(=O)NC[C@H](O)c4ccccc4)[C@]25C(=O)Nc6ccc(C#CC7(O)CCCCCC7)cc65)C(=O)O[C@@H]([C@@H]3c8ccccc8)c9ccccc9 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 K06 compound treatment 548990.0 79200.0 0.4 135090.0 -276000.0 -1.3 -0.6392 -0.4706 2142973 PK04_098206 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(O)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCN(CC7)c8ncccn8)c9cc(C#CCNC(=O)N)ccc19 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 K07 mock treatment 596230.0 126000.0 0.63 556960.0 146000.0 0.68 0.9307 0.9992 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 K08 mock treatment 540110.0 70300.0 0.35 562150.0 151000.0 0.71 0.7498 0.9475 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 K09 compound treatment 142780.0 -327000.0 -1.63 273680.0 -138000.0 -0.65 -1.6129 -0.918 2141136 PK04_098207 COC(=O)C(CC#Cc1ccc2NC(=O)[C@]3([C@@H]([C@@H]4N([C@@H]3c5ccccc5OCCO)[C@H]([C@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)O)c2c1)C(=O)OC 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 K10 compound treatment 588530.0 119000.0 0.59 502410.0 91000.0 0.43 0.7221 0.9872 2143005 PK04_098208 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(O)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N)c7cc(C#CCCO)ccc17 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 K11 compound treatment 176850.0 -293000.0 -1.46 88220.0 -323000.0 -1.52 -2.1094 -0.9998 2141925 PK04_098209 NC(=O)[C@@H]1[C@@H]2N([C@H](c3ccccc3OCCO)[C@@]14C(=O)Nc5ccccc54)[C@H]([C@H](OC2=O)c6ccccc6)c7ccccc7 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 K12 compound treatment 223730.0 -246000.0 -1.23 206410.0 -205000.0 -0.96 -1.5507 -0.9928 2144741 PK04_098210 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccccc4OCCO)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCN(CC7)c8ncccn8)c9ccccc19 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 K13 compound treatment 157370.0 -312000.0 -1.56 374050.0 -37300.0 -0.18 -1.2275 -0.7818 2141147 PK04_098211 OC(=O)[C@@H]1[C@@H]2N([C@H](c3ccc(O)cc3)[C@@]14C(=O)Nc5ccc(C#CC6=CCCCC6)cc54)[C@H]([C@H](OC2=O)c7ccccc7)c8ccccc8 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 K14 compound treatment 317930.0 -152000.0 -0.76 239420.0 -172000.0 -0.81 -1.1083 -0.9995 2143465 PK04_098212 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(OCCO)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NCC=C)c7cc(C#CC8=CCCCC8)ccc17 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 K15 mock treatment 525330.0 55500.0 0.28 376690.0 -34700.0 -0.16 0.0808 0.2509 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 K16 mock treatment 313610.0 -156000.0 -0.78 335690.0 -75700.0 -0.36 -0.8033 -0.9369 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 K17 compound treatment 370800.0 -99000.0 -0.49 389370.0 -22000.0 -0.1 -0.4228 -0.8371 2141530 PK04_098213 OCCOc1ccc(cc1)[C@H]2N3[C@@H]([C@@H](C(=O)Nc4nc5ccccc5s4)[C@]26C(=O)Nc7ccc(C#CCCO)cc76)C(=O)O[C@@H]([C@@H]3c8ccccc8)c9ccccc9 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 K18 compound treatment 535680.0 65900.0 0.33 331840.0 -79500.0 -0.37 -0.0319 -0.0639 2143169 PK04_098214 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(O)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)Nc7nc8ccccc8s7)c9cc(C#CC%10=CCCCC%10)ccc19 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 K19 compound treatment 202350.0 -267000.0 -1.34 215360.0 -196000.0 -0.92 -1.5965 -0.9836 2141707 PK04_098215 OCCOc1ccccc1[C@H]2N3[C@@H]([C@@H](C(=O)N4CCN(CC4)c5ncccn5)[C@]26C(=O)Nc7ccc(C#CCCO)cc76)C(=O)O[C@@H]([C@@H]3c8ccccc8)c9ccccc9 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 K20 compound treatment 495070.0 25300.0 0.13 469530.0 58100.0 0.27 0.2827 0.9384 2143073 PK04_098216 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(O)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCCCCCC7)c8cc(C#CC9(O)CCCCCC9)ccc18 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 K21 compound treatment 499950.0 30200.0 0.15 531760.0 120000.0 0.57 0.5069 0.8652 2141428 PK04_098217 NC(=O)NCC#Cc1ccc2NC(=O)[C@@]3([C@H]([C@H]4N([C@H]3c5ccc(O)cc5)[C@@H]([C@@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)NC[C@H](O)c8ccccc8)c2c1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 K22 compound treatment 91680.0 -378000.0 -1.89 81540.0 -330000.0 -1.55 -2.4324 -0.9952 2142725 PK04_098218 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccccc4OCCO)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N)c7cc(C#CCC(C(=O)OC)C(=O)OC)ccc17 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 K23 mock treatment 542890.0 73100.0 0.37 570280.0 159000.0 0.75 0.7867 0.9457 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 K24 mock treatment 544400.0 74600.0 0.37 378740.0 -32600.0 -0.15 0.1549 0.3844 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 L01 compound treatment 419370.0 -50400.0 -0.25 174560.0 -237000.0 -1.11 -0.9657 -0.8456 2143889 PK04_098219 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccccc4OCCO)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)Nc7nc8ccccc8s7)c9cc(C#Cc%10ccc(OC)cc%10)ccc19 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 L02 compound treatment 193880.0 -276000.0 -1.38 133460.0 -278000.0 -1.31 -1.8988 -0.9997 2141700 PK04_098220 OCCOc1ccccc1[C@H]2N3[C@@H]([C@@H](C(=O)NCC=C)[C@]24C(=O)Nc5ccc(C#CCCO)cc54)C(=O)O[C@@H]([C@@H]3c6ccccc6)c7ccccc7 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 L03 compound treatment 54530.0 -415000.0 -2.07 43060.0 -368000.0 -1.73 -2.6916 -0.996 2142733 PK04_098221 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccccc4OCCO)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCN(CC7)c8ncccn8)c9cc(C#CCC(C(=O)OC)C(=O)OC)ccc19 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 L04 compound treatment 482890.0 13100.0 0.07 523490.0 112000.0 0.53 0.4191 0.7888 2141934 PK04_098222 O[C@@H](CNC(=O)[C@@H]1[C@@H]2N([C@H](c3ccc(O)cc3)[C@@]14C(=O)Nc5ccccc54)[C@H]([C@H](OC2=O)c6ccccc6)c7ccccc7)c8ccccc8 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 L05 compound treatment 463250.0 -6530.0 -0.03 257470.0 -154000.0 -0.72 -0.535 -0.7382 2143873 PK04_098223 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccccc4OCCO)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCCCCCC7)c8cc(C#Cc9ccc(OC)cc9)ccc18 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 L06 compound treatment 519640.0 49900.0 0.25 162140.0 -249000.0 -1.17 -0.6529 -0.5448 2141797 PK04_098224 COc1cc2CCN(Cc2cc1OC)C(=O)[C@@H]3[C@@H]4N([C@H](c5ccc(O)cc5)[C@@]36C(=O)Nc7ccc(C#CCCO)cc76)[C@H]([C@H](OC4=O)c8ccccc8)c9ccccc9 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 L07 mock treatment 532180.0 62400.0 0.31 182610.0 -229000.0 -1.08 -0.5406 -0.4825 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 L08 mock treatment 261560.0 -208000.0 -1.04 328640.0 -82700.0 -0.39 -1.0106 -0.9101 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 L09 compound treatment 365950.0 -104000.0 -0.52 356000.0 -55400.0 -0.26 -0.5509 -0.9493 2142957 PK04_098225 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(O)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NC[C@H](O)c7ccccc7)c8cc(C#CCNC(=O)N)ccc18 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 L10 compound treatment 537280.0 67500.0 0.34 454450.0 43100.0 0.2 0.3816 0.9703 3413983 PK04_098226 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)c2ccc(Br)cc2)[C@@H]3OC(=O)[C@H](Cc4cccc(Br)c4)C/C=C/C[C@@H](Cc5cccc(Br)c5)C(=O)O[C@@H]13 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 L11 compound treatment 289610.0 -180000.0 -0.9 369810.0 -41600.0 -0.2 -0.7746 -0.8411 2142717 PK04_098227 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccccc4OCCO)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NC[C@H](O)c7ccccc7)c8cc(C#CCC(C(=O)OC)C(=O)OC)ccc18 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 L12 compound treatment 498900.0 29100.0 0.15 228100.0 -183000.0 -0.86 -0.5068 -0.5797 3413985 PK04_098228 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)c2c(OC)cccc2OC)[C@@H]3OC(=O)[C@H](Cc4cccc(Br)c4)C/C=C/C[C@@H](Cc5cccc(Br)c5)C(=O)O[C@@H]13 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 L13 compound treatment 212540.0 -257000.0 -1.28 271610.0 -140000.0 -0.66 -1.3734 -0.9516 2143357 PK04_098229 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(OCCO)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NC[C@H](O)c7ccccc7)c8cc(C#CCC(C(=O)OC)C(=O)OC)ccc18 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 L14 compound treatment 445030.0 -24800.0 -0.12 302670.0 -109000.0 -0.51 -0.449 -0.8535 3413987 PK04_098230 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2ccccc2)[C@@H]3OC(=O)[C@H](Cc4cccc(Br)c4)C/C=C/C[C@@H](Cc5cccc(Br)c5)C(=O)O[C@@H]13 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 L15 mock treatment 484360.0 14600.0 0.07 489800.0 78400.0 0.37 0.3123 0.8306 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 L16 mock treatment 501730.0 31900.0 0.16 477300.0 65900.0 0.31 0.332 0.9523 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 L17 compound treatment 500260.0 30500.0 0.15 383060.0 -28300.0 -0.13 0.0134 0.0663 2143089 PK04_098231 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(O)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)Nc7nc8ccccc8s7)c9cc(C#CC%10(O)CCCCCC%10)ccc19 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 L18 compound treatment 496400.0 26600.0 0.13 377980.0 -33400.0 -0.16 -0.0171 -0.0832 3413990 PK04_098232 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2cccc(F)c2)[C@@H]3OC(=O)[C@H](Cc4cccc(Br)c4)C/C=C/C[C@@H](Cc5cccc(Br)c5)C(=O)O[C@@H]13 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 L19 compound treatment 403330.0 -66500.0 -0.33 295440.0 -116000.0 -0.55 -0.6203 -0.9716 2144137 PK04_098233 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccccc4OCCO)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCc8cc(OC)c(OC)cc8C7)c9cc(C#CC%10=CCCCC%10)ccc19 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 L20 compound treatment 370260.0 -99500.0 -0.5 373560.0 -37800.0 -0.18 -0.4773 -0.904 3413992 PK04_098234 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2ccc(OC)cc2)[C@@H]3OC(=O)[C@H](Cc4cccc(Br)c4)C/C=C/C[C@@H](Cc5cccc(Br)c5)C(=O)O[C@@H]13 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 L21 compound treatment 366120.0 -104000.0 -0.52 280190.0 -131000.0 -0.62 -0.8025 -0.9962 2143369 PK04_098235 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(OCCO)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)Nc7nc8ccccc8s7)c9cc(C#CCC(C(=O)OC)C(=O)OC)ccc19 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 L22 compound treatment 381930.0 -87900.0 -0.44 453500.0 42100.0 0.2 -0.1702 -0.3536 3413998 PK04_098236 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2ccc3OCOc3c2)[C@@H]4OC(=O)[C@H](Cc5cccc(Br)c5)C/C=C/C[C@@H](Cc6cccc(Br)c6)C(=O)O[C@@H]14 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 L23 mock treatment 261070.0 -209000.0 -1.04 473400.0 62000.0 0.29 -0.5309 -0.4904 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 L24 mock treatment 427370.0 -42400.0 -0.21 508880.0 97500.0 0.46 0.1745 0.3454 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 M01 compound treatment 492970.0 23200.0 0.12 507630.0 96200.0 0.45 0.402 0.8603 2141977 PK04_098237 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(OCCO)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCc8cc(OC)c(OC)cc8C7)c9cc(C#Cc%10ccc(OC)cc%10)ccc19 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 M02 compound treatment 551460.0 81700.0 0.41 496440.0 85100.0 0.4 0.5713 1.0 2144277 PK04_098238 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(O)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NC[C@H](O)c7ccccc7)c8cc(C#CCCO)ccc18 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 M03 compound treatment 283700.0 -186000.0 -0.93 461530.0 50100.0 0.24 -0.4904 -0.5115 2143353 PK04_098239 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(OCCO)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCCCCCC7)c8cc(C#CCC(C(=O)OC)C(=O)OC)ccc18 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 M04 compound treatment 274190.0 -196000.0 -0.98 338840.0 -72500.0 -0.34 -0.9321 -0.9007 2142753 PK04_098240 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccccc4OCCO)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCCCCCC7)c8cc(C#CC9(O)CCCCCC9)ccc18 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 M05 compound treatment 448720.0 -21100.0 -0.11 235210.0 -176000.0 -0.83 -0.6604 -0.7905 2142713 PK04_098241 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccccc4OCCO)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCCCCCC7)c8cc(C#CCC(C(=O)OC)C(=O)OC)ccc18 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 M06 compound treatment 562190.0 92400.0 0.46 447280.0 35900.0 0.17 0.4457 0.907 2143893 PK04_098242 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccccc4OCCO)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCN(CC7)c8ncccn8)c9cc(C#Cc%10ccc(OC)cc%10)ccc19 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 M07 compound treatment 154370.0 -315000.0 -1.58 150400.0 -261000.0 -1.23 -1.982 -0.9924 2143173 PK04_098243 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(O)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCN(CC7)c8ncccn8)c9cc(C#CC%10=CCCCC%10)ccc19 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 M08 compound treatment 274240.0 -196000.0 -0.98 304710.0 -107000.0 -0.5 -1.0454 -0.9521 2143913 PK04_098244 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccccc4OCCO)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCCCCCC7)c8cc(C#CCNC(=O)N)ccc18 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 M09 mock treatment 174560.0 -295000.0 -1.47 520030.0 109000.0 0.51 -0.6813 -0.4366 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 M10 mock treatment 476890.0 7110.0 0.04 512800.0 101000.0 0.48 0.3624 0.7576 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 M11 compound treatment 108960.0 -361000.0 -1.8 184840.0 -227000.0 -1.07 -2.0278 -0.9686 2143965 PK04_098245 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccccc4OCCO)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N)c7cc(C#CCCO)ccc17 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 M12 compound treatment 429440.0 -40300.0 -0.2 376590.0 -34800.0 -0.16 -0.2582 -0.9947 2144453 PK04_098246 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(O)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCN(CC7)c8ncccn8)c9cc(C#CC%10=CCCCC%10)ccc19 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 M13 mock treatment 487160.0 17400.0 0.09 494880.0 83500.0 0.39 0.3391 0.843 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 M14 mock treatment 468220.0 -1560.0 -0.01 411680.0 291.0 0.0 -0.0046 -0.5746 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 M15 compound treatment 362120.0 -108000.0 -0.54 295040.0 -116000.0 -0.55 -0.7672 -1.0 2142065 PK04_098247 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(OCCO)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NCC=C)c7cc(C#CCC(C(=O)OC)C(=O)OC)ccc17 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 M16 compound treatment 423040.0 -46700.0 -0.23 274410.0 -137000.0 -0.64 -0.6207 -0.9057 2143293 PK04_098248 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(OCCO)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCN(CC7)c8ncccn8)c9cc(C#CCNC(=O)N)ccc19 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 M17 compound treatment 319920.0 -150000.0 -0.75 313990.0 -97400.0 -0.46 -0.8532 -0.9722 2142857 PK04_098249 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccccc4OCCO)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCc8cc(OC)c(OC)cc8C7)c9cc(C#CC%10=CCCCC%10)ccc19 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 M18 compound treatment 463550.0 -6230.0 -0.03 494400.0 83000.0 0.39 0.2541 0.6487 2142613 PK04_098250 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccccc4OCCO)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCN(CC7)c8ncccn8)c9cc(C#Cc%10ccc(OC)cc%10)ccc19 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 M19 compound treatment 319390.0 -150000.0 -0.75 391790.0 -19600.0 -0.09 -0.5963 -0.788 2142697 PK04_098251 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccccc4OCCO)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCc8cc(OC)c(OC)cc8C7)c9cc(C#CCCO)ccc19 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 M20 compound treatment 356930.0 -113000.0 -0.56 368890.0 -42500.0 -0.2 -0.5399 -0.9028 2144821 PK04_098252 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(OCCO)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCN(CC7)c8ncccn8)c9ccccc19 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 M21 compound treatment 521980.0 52200.0 0.26 418520.0 7130.0 0.03 0.2081 0.7916 2142965 PK04_098253 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(O)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N)c7cc(C#CCNC(=O)N)ccc17 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 M22 compound treatment 369280.0 -101000.0 -0.5 361050.0 -50300.0 -0.24 -0.5224 -0.9412 2144777 PK04_098254 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(O)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)Nc7nc8ccccc8s7)c9ccccc19 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 M23 compound treatment 508010.0 38200.0 0.19 367590.0 -43800.0 -0.21 -0.0107 -0.038 2141143 PK04_098255 OCCC#Cc1ccc2NC(=O)[C@]3([C@@H]([C@@H]4N([C@@H]3c5ccc(O)cc5)[C@H]([C@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)O)c2c1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 M24 compound treatment 281000.0 -189000.0 -0.94 453200.0 41800.0 0.2 -0.5277 -0.5478 2144937 PK04_098256 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(O)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)Nc7nc8ccccc8s7)c9ccccc19 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 N01 compound treatment 385920.0 -83900.0 -0.42 280960.0 -130000.0 -0.61 -0.73 -0.9827 2144901 PK04_098257 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccccc4OCCO)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCN(CC7)c8ncccn8)c9ccccc19 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 N02 compound treatment 472170.0 2390.0 0.01 224080.0 -187000.0 -0.88 -0.6146 -0.6975 3413999 PK04_098258 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2ccc(Br)cc2)[C@@H]3OC(=O)[C@H](Cc4cccc(Br)c4)C/C=C/C[C@@H](Cc5cccc(Br)c5)C(=O)O[C@@H]13 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 N03 compound treatment 524260.0 54500.0 0.27 549440.0 138000.0 0.65 0.6515 0.9254 2143297 PK04_098259 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(OCCO)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCc8cc(OC)c(OC)cc8C7)c9cc(C#CCNC(=O)N)ccc19 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 N04 compound treatment 160230.0 -310000.0 -1.55 173400.0 -238000.0 -1.12 -1.8848 -0.9874 3414005 PK04_098260 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2ccc(C#N)cc2)[C@@H]3OC(=O)[C@H](Cc4cccc(Br)c4)C/C=C/C[C@@H](Cc5cccc(Br)c5)C(=O)O[C@@H]13 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 N05 compound treatment 520250.0 50500.0 0.25 484170.0 72800.0 0.34 0.4203 0.9887 2142017 PK04_098261 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(OCCO)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCc8cc(OC)c(OC)cc8C7)c9cc(C#CCNC(=O)N)ccc19 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 N06 compound treatment 280110.0 -190000.0 -0.95 521050.0 110000.0 0.52 -0.3051 -0.2829 3188747 PK04_098262 CCOC(=O)[C@H]1C/C=C/C[C@H](C(=O)OCC)C(=O)O[C@H]2[C@H](OC(=O)CCc3ccccc3)[C@@H](CO)O[C@H](OC)[C@@H]2OC1=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 N07 compound treatment 242730.0 -227000.0 -1.13 170990.0 -240000.0 -1.13 -1.6014 -1.0 2143017 PK04_098263 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(O)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCc8cc(OC)c(OC)cc8C7)c9cc(C#CCCO)ccc19 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 N08 compound treatment 200410.0 -269000.0 -1.35 309280.0 -102000.0 -0.48 -1.291 -0.9037 3188748 PK04_098264 CCOC(=O)[C@H]1C/C=C/C[C@H](C(=O)OCC)C(=O)O[C@H]2[C@H](OC(=O)c3ccc(Br)cc3)[C@@H](CO)O[C@H](OC)[C@@H]2OC1=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 N09 mock treatment 539300.0 69500.0 0.35 413670.0 2280.0 0.01 0.2531 0.7286 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 N10 mock treatment 329440.0 -140000.0 -0.7 360330.0 -51100.0 -0.24 -0.6655 -0.8981 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 N11 compound treatment 247160.0 -223000.0 -1.11 382080.0 -29300.0 -0.14 -0.8837 -0.7887 2144265 PK04_098265 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(O)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NCC=C)c7cc(C#CCCO)ccc17 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 N12 compound treatment 350170.0 -120000.0 -0.6 249200.0 -162000.0 -0.76 -0.9619 -0.9927 3069249 PK04_098266 CCOC(=O)[C@H]1C/C=C/C[C@H](C(=O)OCC)C(=O)O[C@H]2[C@H](OC(=O)c3c(OC)cccc3OC)[C@@H](CO)O[C@H](OC)[C@@H]2OC1=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 N13 mock treatment 269520.0 -200000.0 -1.0 368650.0 -42700.0 -0.2 -0.8494 -0.8326 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 N14 mock treatment 349940.0 -120000.0 -0.6 396570.0 -14800.0 -0.07 -0.4725 -0.7842 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 N15 compound treatment 374170.0 -95600.0 -0.48 344040.0 -67300.0 -0.32 -0.5617 -0.9801 2143165 PK04_098267 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(O)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N)c7cc(C#CC8=CCCCC8)ccc17 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 N16 compound treatment 261850.0 -208000.0 -1.04 258310.0 -153000.0 -0.72 -1.2435 -0.984 3188751 PK04_098268 CCOC(=O)[C@H]1C/C=C/C[C@H](C(=O)OCC)C(=O)O[C@H]2[C@H](OC(=O)Nc3ccccc3)[C@@H](CO)O[C@H](OC)[C@@H]2OC1=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 N17 compound treatment 285060.0 -185000.0 -0.92 328370.0 -83000.0 -0.39 -0.9285 -0.9268 2144365 PK04_098269 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(O)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N)c7cc(C#CC8(O)CCCCCC8)ccc17 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 N18 compound treatment 149380.0 -320000.0 -1.6 138780.0 -273000.0 -1.28 -2.0383 -0.994 3188752 PK04_098270 CCOC(=O)[C@H]1C/C=C/C[C@H](C(=O)OCC)C(=O)O[C@H]2[C@H](OC(=O)Nc3cccc(F)c3)[C@@H](CO)O[C@H](OC)[C@@H]2OC1=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 N19 compound treatment 203630.0 -266000.0 -1.33 208800.0 -203000.0 -0.95 -1.6138 -0.9867 2142105 PK04_098271 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(OCCO)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NCC=C)c7cc(C#CC8(O)CCCCCC8)ccc17 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 N20 compound treatment 343410.0 -126000.0 -0.63 350240.0 -61100.0 -0.29 -0.6497 -0.9367 3068687 PK04_098272 CCOC(=O)[C@H]1C/C=C/C[C@H](C(=O)OCC)C(=O)O[C@H]2[C@H](OC(=O)Nc3ccc(OC)cc3)[C@@H](CO)O[C@H](OC)[C@@H]2OC1=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 N21 compound treatment 499370.0 29600.0 0.15 326680.0 -84700.0 -0.4 -0.1773 -0.4171 2144245 PK04_098273 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(O)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N)c7cc(C#CCNC(=O)N)ccc17 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 N22 compound treatment 193710.0 -276000.0 -1.38 179800.0 -232000.0 -1.09 -1.7453 -0.9932 3068689 PK04_098274 CCOC(=O)[C@H]1C/C=C/C[C@H](C(=O)OCC)C(=O)O[C@H]2[C@H](OC(=O)Nc3ccc4OCOc4c3)[C@@H](CO)O[C@H](OC)[C@@H]2OC1=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 N23 compound treatment 341890.0 -128000.0 -0.64 283520.0 -128000.0 -0.6 -0.877 -0.9995 2143153 PK04_098275 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(O)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCCCCCC7)c8cc(C#CC9=CCCCC9)ccc18 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 N24 compound treatment 142480.0 -327000.0 -1.63 99630.0 -312000.0 -1.47 -2.1928 -0.9985 3188876 PK04_098276 CCOC(=O)[C@H]1C/C=C/C[C@H](C(=O)OCC)C(=O)O[C@H]2[C@H](OC(=O)Nc3ccc(Br)cc3)[C@@H](CO)O[C@H](OC)[C@@H]2OC1=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 O01 compound treatment 236800.0 -233000.0 -1.16 396500.0 -14900.0 -0.07 -0.8723 -0.7483 2143373 PK04_098277 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(OCCO)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCN(CC7)c8ncccn8)c9cc(C#CCC(C(=O)OC)C(=O)OC)ccc19 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 O02 compound treatment 344010.0 -126000.0 -0.63 225760.0 -186000.0 -0.87 -1.0616 -0.9869 2142209 PK04_098278 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(OCCO)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)Nc7nc8ccccc8s7)c9cc(C#CC%10=CCCCC%10)ccc19 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 O03 compound treatment 490920.0 21100.0 0.11 269840.0 -142000.0 -0.67 -0.3961 -0.5877 2144345 PK04_098279 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(O)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NCC=C)c7cc(C#CC8(O)CCCCCC8)ccc17 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 O04 compound treatment 397690.0 -72100.0 -0.36 444710.0 33300.0 0.16 -0.1438 -0.3661 2142673 PK04_098280 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccccc4OCCO)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCCCCCC7)c8cc(C#CCCO)ccc18 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 O05 compound treatment 332800.0 -137000.0 -0.68 330100.0 -81300.0 -0.38 -0.7541 -0.9622 2143977 PK04_098281 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccccc4OCCO)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCc8cc(OC)c(OC)cc8C7)c9cc(C#CCCO)ccc19 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 O06 compound treatment 505600.0 35800.0 0.18 326000.0 -85400.0 -0.4 -0.1575 -0.3583 2142077 PK04_098282 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(OCCO)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NC[C@H](O)c7ccccc7)c8cc(C#CCC(C(=O)OC)C(=O)OC)ccc18 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 O07 compound treatment 312510.0 -157000.0 -0.79 407780.0 -3610.0 -0.02 -0.5674 -0.7222 2141985 PK04_098283 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(OCCO)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NCC=C)c7cc(C#CCNC(=O)N)ccc17 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 O08 compound treatment 158560.0 -311000.0 -1.55 150580.0 -261000.0 -1.23 -1.9666 -0.9931 2143485 PK04_098284 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(OCCO)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N)c7cc(C#CC8=CCCCC8)ccc17 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 O09 compound treatment 494450.0 24700.0 0.12 336220.0 -75200.0 -0.35 -0.1629 -0.4351 2144665 PK04_098285 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(OCCO)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCc8cc(OC)c(OC)cc8C7)c9ccccc19 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 O10 compound treatment 293700.0 -176000.0 -0.88 436260.0 24900.0 0.12 -0.5392 -0.6077 2143273 PK04_098286 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(OCCO)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCCCCCC7)c8cc(C#CCNC(=O)N)ccc18 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 O11 mock treatment 532050.0 62300.0 0.31 542640.0 131000.0 0.62 0.6564 0.9496 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 O12 mock treatment 488540.0 18800.0 0.09 323600.0 -87800.0 -0.41 -0.2257 -0.5332 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 O13 compound treatment 620530.0 151000.0 0.75 450180.0 38800.0 0.18 0.6614 0.8538 2144773 PK04_098287 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(O)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N)c7ccccc17 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 O14 compound treatment 328810.0 -141000.0 -0.7 341130.0 -70300.0 -0.33 -0.7316 -0.9405 2143945 PK04_098288 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccccc4OCCO)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NCC=C)c7cc(C#CCCO)ccc17 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 O15 compound treatment 370820.0 -99000.0 -0.49 435580.0 24200.0 0.11 -0.2691 -0.5305 2144317 PK04_098289 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(O)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NC[C@H](O)c7ccccc7)c8cc(C#CCC(C(=O)OC)C(=O)OC)ccc18 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 O16 compound treatment 361760.0 -108000.0 -0.54 409990.0 -1400.0 -0.01 -0.3862 -0.7157 2143905 PK04_098290 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccccc4OCCO)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NCC=C)c7cc(C#CCNC(=O)N)ccc17 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 O17 compound treatment 309560.0 -160000.0 -0.8 419460.0 8070.0 0.04 -0.539 -0.6728 2143917 PK04_098291 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccccc4OCCO)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NC[C@H](O)c7ccccc7)c8cc(C#CCNC(=O)N)ccc18 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 O18 compound treatment 455840.0 -13900.0 -0.07 358180.0 -53200.0 -0.25 -0.2262 -0.8708 2144253 PK04_098292 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(O)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCN(CC7)c8ncccn8)c9cc(C#CCNC(=O)N)ccc19 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 O19 compound treatment 197970.0 -272000.0 -1.36 162400.0 -249000.0 -1.17 -1.7881 -0.9973 2144105 PK04_098293 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccccc4OCCO)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NCC=C)c7cc(C#CC8=CCCCC8)ccc17 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 O20 compound treatment 364370.0 -105000.0 -0.53 237630.0 -174000.0 -0.82 -0.9502 -0.9774 2144293 PK04_098294 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(O)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCN(CC7)c8ncccn8)c9cc(C#CCCO)ccc19 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 O21 compound treatment 514030.0 44200.0 0.22 399310.0 -12100.0 -0.06 0.1161 0.5088 2142997 PK04_098295 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(O)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NC[C@H](O)c7ccccc7)c8cc(C#CCCO)ccc18 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 O22 compound treatment 245170.0 -225000.0 -1.12 208050.0 -203000.0 -0.96 -1.4696 -0.9968 2144737 PK04_098296 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccccc4OCCO)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)Nc7nc8ccccc8s7)c9ccccc19 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 O23 compound treatment 535210.0 65400.0 0.33 518440.0 107000.0 0.5 0.5871 0.9781 2141452 PK04_098297 COC(=O)C(CC#Cc1ccc2NC(=O)[C@@]3([C@H]([C@H]4N([C@H]3c5ccc(O)cc5)[C@@H]([C@@H](OC4=O)c6ccccc6)c7ccccc7)C(=O)N)c2c1)C(=O)OC 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 O24 compound treatment 410400.0 -59400.0 -0.3 293020.0 -118000.0 -0.56 -0.6034 -0.9565 2142677 PK04_098298 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccccc4OCCO)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NC[C@H](O)c7ccccc7)c8cc(C#CCCO)ccc18 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 P01 compound treatment 18020.0 -452000.0 -2.26 47810.0 -364000.0 -1.71 -2.8047 -0.9907 2144005 PK04_098299 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccccc4OCCO)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N)c7cc(C#CCC(C(=O)OC)C(=O)OC)ccc17 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 P02 compound treatment 48800.0 -421000.0 -2.1 68220.0 -343000.0 -1.61 -2.6281 -0.9915 3068772 PK04_098300 CCOC(=O)[C@H]1C/C=C/C[C@H](C(=O)OCC)C(=O)O[C@H]2[C@H](OC(=O)Nc3ccc(C#N)cc3)[C@@H](CO)O[C@H](OC)[C@@H]2OC1=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 P03 compound treatment 359170.0 -111000.0 -0.55 223270.0 -188000.0 -0.88 -1.0163 -0.9743 2142593 PK04_098301 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccccc4OCCO)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCCCCCC7)c8cc(C#Cc9ccc(OC)cc9)ccc18 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 P04 compound treatment 158630.0 -311000.0 -1.55 149690.0 -262000.0 -1.23 -1.9693 -0.9933 3000699 PK04_098302 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)CCc2ccccc2)[C@H](OC(=O)c3cc4ccccc4[nH]3)[C@H]1OC(=O)c5cc6ccccc6[nH]5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 P05 compound treatment 204220.0 -266000.0 -1.33 151950.0 -259000.0 -1.22 -1.8008 -0.9991 2144921 PK04_098303 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(O)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCCCCCC7)c8ccccc18 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 P06 compound treatment 123740.0 -346000.0 -1.73 156430.0 -255000.0 -1.2 -2.0701 -0.9841 3000700 PK04_098304 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)c2ccc(Br)cc2)[C@H](OC(=O)c3cc4ccccc4[nH]3)[C@H]1OC(=O)c5cc6ccccc6[nH]5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 P07 compound treatment 314210.0 -156000.0 -0.78 188180.0 -223000.0 -1.05 -1.2918 -0.989 2143937 PK04_098305 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccccc4OCCO)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCc8cc(OC)c(OC)cc8C7)c9cc(C#CCNC(=O)N)ccc19 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 P08 compound treatment 216240.0 -254000.0 -1.27 143440.0 -268000.0 -1.26 -1.7866 -1.0 3000701 PK04_098306 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)c2c(OC)cccc2OC)[C@H](OC(=O)c3cc4ccccc4[nH]3)[C@H]1OC(=O)c5cc6ccccc6[nH]5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 P09 compound treatment 189470.0 -280000.0 -1.4 344990.0 -66400.0 -0.31 -1.2108 -0.8441 2144785 PK04_098307 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(O)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCc8cc(OC)c(OC)cc8C7)c9ccccc19 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 P10 compound treatment 328870.0 -141000.0 -0.7 162880.0 -249000.0 -1.17 -1.3242 -0.9705 3089322 PK04_098308 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2ccccc2)[C@H](OC(=O)c3cc4ccccc4[nH]3)[C@H]1OC(=O)c5cc6ccccc6[nH]5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 P11 mock treatment 197340.0 -272000.0 -1.36 169140.0 -242000.0 -1.14 -1.7679 -0.9961 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 P12 mock treatment 387950.0 -81800.0 -0.41 273670.0 -138000.0 -0.65 -0.7471 -0.9753 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 P13 compound treatment 274970.0 -195000.0 -0.97 291680.0 -120000.0 -0.56 -1.0862 -0.9662 2144213 PK04_098309 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(O)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCN(CC7)c8ncccn8)c9cc(C#Cc%10ccc(OC)cc%10)ccc19 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 P14 compound treatment 252320.0 -217000.0 -1.09 379360.0 -32000.0 -0.15 -0.8745 -0.7976 3089323 PK04_098310 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2cccc(F)c2)[C@H](OC(=O)c3cc4ccccc4[nH]3)[C@H]1OC(=O)c5cc6ccccc6[nH]5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 P15 compound treatment 178240.0 -292000.0 -1.46 244740.0 -167000.0 -0.78 -1.5839 -0.9578 2144225 PK04_098311 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(O)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)NCC=C)c7cc(C#CCNC(=O)N)ccc17 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 P16 compound treatment 280580.0 -189000.0 -0.94 297850.0 -114000.0 -0.53 -1.0458 -0.9635 3000703 PK04_098312 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2ccc(OC)cc2)[C@H](OC(=O)c3cc4ccccc4[nH]3)[C@H]1OC(=O)c5cc6ccccc6[nH]5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 P17 compound treatment 296910.0 -173000.0 -0.86 316230.0 -95200.0 -0.45 -0.927 -0.9532 2141953 PK04_098313 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(OCCO)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCCCCCC7)c8cc(C#Cc9ccc(OC)cc9)ccc18 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 P18 compound treatment 234560.0 -235000.0 -1.17 277350.0 -134000.0 -0.63 -1.2765 -0.9574 3000704 PK04_098314 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2ccc3OCOc3c2)[C@H](OC(=O)c4cc5ccccc5[nH]4)[C@H]1OC(=O)c6cc7ccccc7[nH]6 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 P19 compound treatment 425090.0 -44700.0 -0.22 293940.0 -117000.0 -0.55 -0.5485 -0.9205 2143337 PK04_098315 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(OCCO)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCc8cc(OC)c(OC)cc8C7)c9cc(C#CCCO)ccc19 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 P20 compound treatment 186650.0 -283000.0 -1.41 153280.0 -258000.0 -1.21 -1.8584 -0.9971 3089326 PK04_098316 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2ccc(Br)cc2)[C@H](OC(=O)c3cc4ccccc4[nH]3)[C@H]1OC(=O)c5cc6ccccc6[nH]5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 P21 compound treatment 275080.0 -195000.0 -0.97 263970.0 -147000.0 -0.69 -1.1779 -0.9863 2143233 PK04_098317 COCCOC(=O)N1C(=O)[C@]2([C@@H]([C@@H]3N([C@@H]2c4ccc(OCCO)cc4)[C@H]([C@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)N7CCCCCCC7)c8cc(C#Cc9ccc(OC)cc9)ccc18 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 P22 compound treatment 329250.0 -141000.0 -0.7 324080.0 -87300.0 -0.41 -0.7867 -0.9674 3089328 PK04_098318 CO[C@H]1O[C@H](CO)[C@@H](OC(=O)Nc2ccc(C#N)cc2)[C@H](OC(=O)c3cc4ccccc4[nH]3)[C@H]1OC(=O)c5cc6ccccc6[nH]5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 P23 compound treatment 402150.0 -67600.0 -0.34 221240.0 -190000.0 -0.89 -0.8713 -0.9113 2142969 PK04_098319 COCCOC(=O)N1C(=O)[C@@]2([C@H]([C@H]3N([C@H]2c4ccc(O)cc4)[C@@H]([C@@H](OC3=O)c5ccccc5)c6ccccc6)C(=O)Nc7nc8ccccc8s7)c9cc(C#CCNC(=O)N)ccc19 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2098 P24 compound treatment 388080.0 -81700.0 -0.41 268450.0 -143000.0 -0.67 -0.764 -0.9714 3189006 PK04_098320 CC(C)[Si](OCCCNS(=O)(=O)c1ccc(Br)cc1)(C(C)C)C(C)C 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 A01 compound treatment 566740.0 125000.0 0.62 192320.0 -223000.0 -1.05 -0.3005 -0.2465 3052787 PK04_100001 CC(C)C[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3ccc(O)cc3)C(=O)NCCCCCNC(=O)CS 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 A02 compound treatment 184010.0 -258000.0 -1.29 164550.0 -251000.0 -1.18 -1.7446 -0.999 3052649 PK04_100002 C[N+](C)(C)CCCCCCNC(=O)[C@@H]1C[C@H]2N([C@@H]1c3cccc(OCCO)c3)C(=O)CNC2=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 A03 compound treatment 186740.0 -255000.0 -1.27 174240.0 -241000.0 -1.13 -1.7027 -0.9983 3176622 PK04_100003 CN(C)CCCCNC(=O)[C@H]1C[C@@H]2N([C@H]1c3ccc(O)cc3)C(=O)[C@@H]4CCCN4C2=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 A04 compound treatment 191640.0 -250000.0 -1.25 172320.0 -243000.0 -1.14 -1.6918 -0.999 3175961 PK04_100004 CC(=O)NCCCC[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3cccc(OCCO)c3)C(=O)NCCCCCC[N+](C)(C)C 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 A05 compound treatment 197170.0 -245000.0 -1.22 220210.0 -195000.0 -0.92 -1.513 -0.9899 3176556 PK04_100005 CN(C)CCCCNC(=O)[C@H]1C[C@@H]2N([C@H]1c3ccc(O)cc3)C(=O)[C@H](Cc4ccccc4)NC2=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 A06 compound treatment 181650.0 -260000.0 -1.3 306290.0 -109000.0 -0.51 -1.2815 -0.917 3176630 PK04_100006 C[N+](C)(C)CCCCCCNC(=O)[C@H]1C[C@@H]2N([C@H]1c3ccc(O)cc3)C(=O)[C@@H]4CCCN4C2=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 A07 compound treatment 189280.0 -253000.0 -1.26 168190.0 -247000.0 -1.16 -1.7138 -0.9991 3175901 PK04_100007 NCCCCCCNC(=O)[C@@H]1C[C@H]2N([C@@H]1c3ccc(O)cc3)C(=O)[C@H](CCCCN)NC2=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 A08 compound treatment 189170.0 -253000.0 -1.26 204870.0 -210000.0 -0.99 -1.5922 -0.9927 3176729 PK04_100008 C[N+](C)(C)CCCCCCNC(=O)[C@H]1C[C@@H]2N([C@H]1c3ccc(O)cc3)C(=O)[C@H](CCCC[N+](C)(C)C)NC2=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 A09 compound treatment 174270.0 -268000.0 -1.34 306100.0 -109000.0 -0.51 -1.3082 -0.9134 3052580 PK04_100009 CC(C)C[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3cccc(OCCO)c3)C(=O)OCCOc4ccc(cc4)[C@H]5N6[C@@H]([C@@H](C(=O)OCC=C)[C@]57C(=O)Nc8ccc(I)cc87)C(=O)O[C@@H]([C@@H]6c9ccccc9)c%10ccccc%10 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 A10 compound treatment 428090.0 -13900.0 -0.07 499850.0 84700.0 0.4 0.2327 0.5751 3176731 PK04_100010 C[N+](C)(C)CCCCNC(=O)[C@H]1C[C@@H]2N([C@H]1c3ccc(O)cc3)C(=O)[C@H](CCCC[N+](C)(C)C)NC2=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 A11 compound treatment 281810.0 -160000.0 -0.8 298160.0 -117000.0 -0.55 -0.9548 -0.9833 3176633 PK04_100011 Oc1ccc(cc1)[C@H]2[C@H](C[C@@H]3N2C(=O)[C@@H]4CCCN4C3=O)C(=O)OCCOc5ccc(cc5)[C@H]6N7[C@@H]([C@@H](C(=O)OCC=C)[C@]68C(=O)Nc9ccc(I)cc98)C(=O)O[C@@H]([C@@H]7c%10ccccc%10)c%11ccccc%11 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 A12 compound treatment 450330.0 8330.0 0.04 173650.0 -241000.0 -1.14 -0.7737 -0.6808 3176445 PK04_100012 CC(=O)NCCCC[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3ccc(O)cc3)C(=O)NCCCC[N+](C)(C)C 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 A13 mock treatment 204970.0 -237000.0 -1.18 187280.0 -228000.0 -1.07 -1.5949 -0.9988 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 A14 mock treatment 512640.0 70600.0 0.35 193700.0 -221000.0 -1.04 -0.487 -0.4429 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 A15 compound treatment 351950.0 -90100.0 -0.45 390950.0 -24200.0 -0.11 -0.3984 -0.8589 3175963 PK04_100013 CC(=O)NCCCC[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3cccc(OCCO)c3)C(=O)OCCOc4ccc(cc4)[C@@H]5N6[C@H]([C@H](C(=O)OCC=C)[C@@]57C(=O)Nc8ccc(I)cc87)C(=O)O[C@H]([C@H]6c9ccccc9)c%10ccccc%10 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 A16 compound treatment 228480.0 -214000.0 -1.07 380040.0 -35100.0 -0.17 -0.8708 -0.8069 3052785 PK04_100014 CC(C)C[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3ccc(O)cc3)C(=O)NCCCCCCNC(=O)CS 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 A17 compound treatment 488980.0 47000.0 0.23 412350.0 -2780.0 -0.01 0.1567 0.6667 3052837 PK04_100015 Oc1ccc(cc1)[C@H]2[C@H](C[C@@H]3N2C(=O)[C@@H]4CCCN4C3=O)C(=O)OCCOc5ccc(cc5)[C@@H]6N7[C@H]([C@H](C(=O)OCC=C)[C@@]68C(=O)Nc9ccc(I)cc98)C(=O)O[C@H]([C@H]7c%10ccccc%10)c%11ccccc%11 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 A18 compound treatment 464920.0 22900.0 0.11 488760.0 73600.0 0.35 0.3258 0.8933 3176262 PK04_100016 OCCOc1cccc(c1)[C@H]2[C@H](C[C@@H]3N2C(=O)CNC3=O)C(=O)NCCCCCCNC(=O)CS 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 A19 compound treatment 469680.0 27700.0 0.14 254330.0 -161000.0 -0.76 -0.4371 -0.5684 3176686 PK04_100017 CN(C)CCCC[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3ccc(O)cc3)C(=O)O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 A20 compound treatment 488440.0 46400.0 0.23 457920.0 42800.0 0.2 0.3063 0.9975 3176371 PK04_100018 C[N+](C)(C)CCCC[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3cccc(OCCO)c3)C(=O)NCc4ccc(F)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 A21 compound treatment 214570.0 -227000.0 -1.14 357330.0 -57800.0 -0.27 -0.9954 -0.8523 3052829 PK04_100019 OC(=O)[C@@H]1C[C@H]2N([C@@H]1c3ccc(O)cc3)C(=O)[C@@H]4CCCN4C2=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 A22 compound treatment 199920.0 -242000.0 -1.21 338830.0 -76300.0 -0.36 -1.1087 -0.8791 3052833 PK04_100020 Oc1ccc(cc1)[C@H]2[C@H](C[C@@H]3N2C(=O)[C@@H]4CCCN4C3=O)C(=O)NCc5ccc(F)cc5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 A23 compound treatment 506010.0 64000.0 0.32 324220.0 -90900.0 -0.43 -0.0763 -0.1429 3052878 PK04_100021 CN(C)CCCC[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3ccc(O)cc3)C(=O)O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 A24 compound treatment 245330.0 -197000.0 -0.98 289370.0 -126000.0 -0.59 -1.1128 -0.9705 3052694 PK04_100022 CN(C)CCCC[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3cccc(OCCO)c3)C(=O)NCCCCCNC(=O)CS 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 B01 compound treatment 547450.0 105000.0 0.53 531200.0 116000.0 0.55 0.7585 0.9998 3052928 PK04_100023 CN(C)CCCCCCNC(=O)[C@@H]1C[C@H]2N([C@@H]1c3ccc(O)cc3)C(=O)[C@H](CCCCN)NC2=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 B02 compound treatment 398650.0 -43400.0 -0.22 323870.0 -91300.0 -0.43 -0.4566 -0.9498 3052800 PK04_100024 Oc1ccc(cc1)[C@@H]2[C@@H](C[C@H]3N2C(=O)[C@H](Cc4ccccc4)NC3=O)C(=O)OCCOc5ccc(cc5)[C@H]6N7[C@@H]([C@@H](C(=O)OCC=C)[C@]68C(=O)Nc9ccc(I)cc98)C(=O)O[C@@H]([C@@H]7c%10ccccc%10)c%11ccccc%11 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 B03 compound treatment 519520.0 77500.0 0.39 518460.0 103000.0 0.49 0.6174 0.9937 3052842 PK04_100025 NCCCCCCNC(=O)[C@@H]1C[C@H]2N([C@@H]1c3ccc(O)cc3)C(=O)CNC2=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 B04 compound treatment 529280.0 87300.0 0.44 503310.0 88200.0 0.41 0.6015 0.9997 3176782 PK04_100026 C[N+](C)(C)CCCC[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3ccc(O)cc3)C(=O)OCCOc4ccc(cc4)[C@H]5N6[C@@H]([C@@H](C(=O)OCC=C)[C@]57C(=O)Nc8ccc(I)cc87)C(=O)O[C@@H]([C@@H]6c9ccccc9)c%10ccccc%10 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 B05 compound treatment 528200.0 86200.0 0.43 537290.0 122000.0 0.57 0.7107 0.9899 3175971 PK04_100027 CC(C)C[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3cccc(OCCO)c3)C(=O)NCCCCCCN 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 B06 compound treatment 498270.0 56300.0 0.28 364930.0 -50200.0 -0.24 0.0318 0.0865 3176561 PK04_100028 Oc1ccc(cc1)[C@@H]2[C@@H](C[C@H]3N2C(=O)[C@H](Cc4ccccc4)NC3=O)C(=O)NCCCCCCNC(=O)CS 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 B07 compound treatment 494600.0 52600.0 0.26 521280.0 106000.0 0.5 0.5388 0.955 3176369 PK04_100029 C[N+](C)(C)CCCC[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3cccc(OCCO)c3)C(=O)NCCCCCCN 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 B08 compound treatment 552960.0 111000.0 0.55 429380.0 14300.0 0.07 0.4393 0.7869 3176441 PK04_100030 CC(=O)NCCCC[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3ccc(O)cc3)C(=O)NCCCCCCNC(=O)CS 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 B09 compound treatment 380690.0 -61300.0 -0.31 374690.0 -40400.0 -0.19 -0.351 -0.9738 3052641 PK04_100031 OCCOc1cccc(c1)[C@@H]2[C@@H](C[C@H]3N2C(=O)[C@@H]4CCCN4C3=O)C(=O)OCCOc5ccc(cc5)[C@@H]6N7[C@H]([C@H](C(=O)OCC=C)[C@@]68C(=O)Nc9ccccc98)C(=O)O[C@H]([C@H]7c%10ccccc%10)c%11ccccc%11 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 B10 compound treatment 548830.0 107000.0 0.53 565280.0 150000.0 0.71 0.8767 0.9904 3176555 PK04_100032 CN(C)CCCCCCNC(=O)[C@@H]1C[C@H]2N([C@@H]1c3ccc(O)cc3)C(=O)[C@H](Cc4ccccc4)NC2=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 B11 compound treatment 388450.0 -53600.0 -0.27 550120.0 135000.0 0.63 0.2599 0.3772 3176554 PK04_100033 CC(=O)NCCCC[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3ccc(O)cc3)C(=O)OCCOc4ccc(cc4)[C@@H]5N6[C@H]([C@H](C(=O)OCC=C)[C@@]57C(=O)Nc8ccccc87)C(=O)O[C@H]([C@H]6c9ccccc9)c%10ccccc%10 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 B12 compound treatment 270620.0 -171000.0 -0.86 502880.0 87800.0 0.41 -0.3134 -0.3298 3052747 PK04_100034 CN(C)CCCCCCNC(=O)[C@@H]1C[C@H]2N([C@@H]1c3ccc(O)cc3)C(=O)[C@H](CCCCNC(=O)C)NC2=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 B13 mock treatment 513440.0 71400.0 0.36 568160.0 153000.0 0.72 0.7613 0.9476 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 B14 mock treatment 586100.0 144000.0 0.72 496520.0 81400.0 0.38 0.7796 0.9564 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 B15 compound treatment 303850.0 -138000.0 -0.69 399480.0 -15600.0 -0.07 -0.54 -0.7781 3052707 PK04_100035 C[N+](C)(C)CCCC[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3cccc(OCCO)c3)C(=O)OCCOc4ccc(cc4)[C@@H]5N6[C@H]([C@H](C(=O)OCC=C)[C@@]57C(=O)Nc8ccccc87)C(=O)O[C@H]([C@H]6c9ccccc9)c%10ccccc%10 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 B16 compound treatment 371610.0 -70400.0 -0.35 347960.0 -67200.0 -0.32 -0.472 -0.9986 3176447 PK04_100036 CC(=O)NCCCC[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3ccc(O)cc3)C(=O)OCCOc4ccc(cc4)[C@@H]5N6[C@H]([C@H](C(=O)OCC=C)[C@@]57C(=O)Nc8ccc(I)cc87)C(=O)O[C@H]([C@H]6c9ccccc9)c%10ccccc%10 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 B17 compound treatment 532380.0 90400.0 0.45 441190.0 26100.0 0.12 0.4059 0.8677 3176194 PK04_100037 NCCCCCNC(=O)[C@H]1C[C@@H]2N([C@H]1c3cccc(OCCO)c3)C(=O)[C@@H]4CCCN4C2=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 B18 compound treatment 449460.0 7460.0 0.04 527690.0 113000.0 0.53 0.4007 0.755 3176504 PK04_100038 CC(C)C[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3ccc(O)cc3)C(=O)NCCCCCNC(=O)CS 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 B19 compound treatment 422500.0 -19500.0 -0.1 479160.0 64000.0 0.3 0.1441 0.4552 3176439 PK04_100039 CC(=O)NCCCC[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3ccc(O)cc3)C(=O)NCCCCCN 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 B20 compound treatment 449810.0 7810.0 0.04 550950.0 136000.0 0.64 0.4793 0.7489 3176678 PK04_100040 Oc1ccc(cc1)[C@@H]2[C@@H](C[C@H]3N2C(=O)CNC3=O)C(=O)NCCCCCNC(=O)CS 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 B21 compound treatment 514240.0 72200.0 0.36 533560.0 118000.0 0.56 0.649 0.9779 3176260 PK04_100041 NCCCCCNC(=O)[C@@H]1C[C@H]2N([C@@H]1c3cccc(OCCO)c3)C(=O)CNC2=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 B22 compound treatment 608990.0 167000.0 0.83 542300.0 127000.0 0.6 1.0127 0.9867 3176621 PK04_100042 CN(C)CCCCCCNC(=O)[C@H]1C[C@@H]2N([C@H]1c3ccc(O)cc3)C(=O)[C@@H]4CCCN4C2=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 B23 compound treatment 487000.0 45000.0 0.22 527120.0 112000.0 0.53 0.5314 0.9279 3176370 PK04_100043 C[N+](C)(C)CCCC[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3cccc(OCCO)c3)C(=O)NCCCCCN 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 B24 compound treatment 454940.0 12900.0 0.06 451140.0 36000.0 0.17 0.1655 0.9127 3176636 PK04_100044 Oc1ccc(cc1)[C@H]2[C@H](C[C@@H]3N2C(=O)[C@@H]4CCCN4C3=O)C(=O)OCCOc5ccc(cc5)[C@H]6N7[C@@H]([C@@H](C(=O)OCC=C)[C@]68C(=O)Nc9ccccc98)C(=O)O[C@@H]([C@@H]7c%10ccccc%10)c%11ccccc%11 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 C01 compound treatment 476290.0 34300.0 0.17 448040.0 32900.0 0.15 0.2306 0.9987 3052532 PK04_100045 CC(=O)NCCCC[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3cccc(OCCO)c3)C(=O)NCCCCCNC(=O)CS 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 C02 compound treatment 471770.0 29800.0 0.15 425320.0 10200.0 0.05 0.139 0.89 3052638 PK04_100046 C[N+](C)(C)CCCCCCNC(=O)[C@@H]1C[C@H]2N([C@@H]1c3cccc(OCCO)c3)C(=O)[C@@H]4CCCN4C2=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 C03 compound treatment 451430.0 9430.0 0.05 471300.0 56200.0 0.26 0.2201 0.8202 3052540 PK04_100047 CC(C)C[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3cccc(OCCO)c3)C(=O)NCCCCN(C)C 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 C04 compound treatment 200510.0 -241000.0 -1.21 263490.0 -152000.0 -0.71 -1.3572 -0.9686 3052751 PK04_100048 CC(=O)NCCCC[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3ccc(O)cc3)C(=O)NCCCCCC[N+](C)(C)C 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 C05 compound treatment 488230.0 46200.0 0.23 196870.0 -218000.0 -1.03 -0.5627 -0.5347 3052702 PK04_100049 CN(C)CCCCNC(=O)[C@H]1C[C@@H]2N([C@H]1c3cccc(OCCO)c3)C(=O)[C@H](CCCC[N+](C)(C)C)NC2=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 C06 compound treatment 410740.0 -31300.0 -0.16 415650.0 520.0 0.0 -0.1087 -0.6959 3176680 PK04_100050 C[N+](C)(C)CCCCCCNC(=O)[C@H]1C[C@@H]2N([C@H]1c3ccc(O)cc3)C(=O)CNC2=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 C07 compound treatment 463550.0 21500.0 0.11 267900.0 -147000.0 -0.69 -0.4136 -0.5901 3052743 PK04_100051 CN(C)CCCCNC(=O)[C@@H]1C[C@H]2N([C@@H]1c3cccc(OCCO)c3)C(=O)[C@H](CCCCN)NC2=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 C08 compound treatment 316720.0 -125000.0 -0.63 422460.0 7330.0 0.03 -0.4181 -0.6671 3176043 PK04_100052 CC(C)C[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3cccc(OCCO)c3)C(=O)NCCCCCC[N+](C)(C)C 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 C09 compound treatment 299560.0 -142000.0 -0.71 422490.0 7360.0 0.03 -0.4786 -0.6719 3052925 PK04_100053 C[N+](C)(C)CCCC[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3ccc(O)cc3)C(=O)OCCOc4ccc(cc4)[C@H]5N6[C@@H]([C@@H](C(=O)OCC=C)[C@]57C(=O)Nc8ccc(I)cc87)C(=O)O[C@@H]([C@@H]6c9ccccc9)c%10ccccc%10 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 C10 compound treatment 356410.0 -85600.0 -0.43 268580.0 -147000.0 -0.69 -0.7897 -0.9736 3176324 PK04_100054 C[N+](C)(C)CCCCNC(=O)[C@H]1C[C@@H]2N([C@H]1c3cccc(OCCO)c3)C(=O)[C@H](CCCC[N+](C)(C)C)NC2=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 C11 mock treatment 393780.0 -48200.0 -0.24 466410.0 51300.0 0.24 3.0E-4 8.0E-4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 C12 mock treatment 306650.0 -135000.0 -0.68 289930.0 -125000.0 -0.59 -0.8944 -0.9976 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 C13 compound treatment 245640.0 -196000.0 -0.98 289600.0 -126000.0 -0.59 -1.111 -0.9705 3176376 PK04_100055 C[N+](C)(C)CCCC[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3cccc(OCCO)c3)C(=O)OCCOc4ccc(cc4)[C@H]5N6[C@@H]([C@@H](C(=O)OCC=C)[C@]57C(=O)Nc8ccc(I)cc87)C(=O)O[C@@H]([C@@H]6c9ccccc9)c%10ccccc%10 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 C14 compound treatment 441320.0 -681.0 0.0 416380.0 1250.0 0.01 0.0018 0.2583 3176324 PK04_100056 C[N+](C)(C)CCCCNC(=O)[C@H]1C[C@@H]2N([C@H]1c3cccc(OCCO)c3)C(=O)[C@H](CCCC[N+](C)(C)C)NC2=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 C15 mock treatment 388090.0 -53900.0 -0.27 451690.0 36600.0 0.17 -0.0688 -0.2153 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 C16 mock treatment 415200.0 -26800.0 -0.13 412010.0 -3120.0 -0.01 -0.105 -0.78 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 C17 compound treatment 397620.0 -44400.0 -0.22 522620.0 107000.0 0.51 0.2008 0.3637 3052884 PK04_100057 CN(C)CCCC[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3ccc(O)cc3)C(=O)OCCOc4ccc(cc4)[C@@H]5N6[C@H]([C@H](C(=O)OCC=C)[C@@]57C(=O)Nc8ccc(I)cc87)C(=O)O[C@H]([C@H]6c9ccccc9)c%10ccccc%10 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 C18 compound treatment 362580.0 -79400.0 -0.4 486190.0 71100.0 0.33 -0.0441 -0.0851 3176562 PK04_100058 Oc1ccc(cc1)[C@H]2[C@H](C[C@@H]3N2C(=O)[C@H](Cc4ccccc4)NC3=O)C(=O)NCCCCCCNC(=O)CS 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 C19 compound treatment 443200.0 1200.0 0.01 481250.0 66100.0 0.31 0.2242 0.7206 3176124 PK04_100059 OCCOc1cccc(c1)[C@@H]2[C@@H](C[C@H]3N2C(=O)[C@@H]4CCCN4C3=O)C(=O)O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 C20 compound treatment 375680.0 -66300.0 -0.33 458460.0 43300.0 0.2 -0.0901 -0.2317 3052784 PK04_100060 CC(C)C[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3ccc(O)cc3)C(=O)NCc4ccc(F)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 C21 compound treatment 354610.0 -87400.0 -0.44 501550.0 86400.0 0.41 -0.0212 -0.0355 3052792 PK04_100061 OC(=O)[C@@H]1C[C@H]2N([C@@H]1c3ccc(O)cc3)C(=O)[C@H](Cc4ccccc4)NC2=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 C22 compound treatment 298130.0 -144000.0 -0.72 439450.0 24300.0 0.11 -0.4272 -0.5871 3052749 PK04_100062 CC(=O)NCCCC[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3ccc(O)cc3)C(=O)NCc4ccc(F)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 C23 compound treatment 478320.0 36300.0 0.18 363420.0 -51700.0 -0.24 -0.0437 -0.1441 3176204 PK04_100063 OCCOc1cccc(c1)[C@H]2[C@H](C[C@@H]3N2C(=O)CNC3=O)C(=O)O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 C24 compound treatment 479490.0 37500.0 0.19 405280.0 -9850.0 -0.05 0.0996 0.5166 3176041 PK04_100064 CC(C)C[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3cccc(OCCO)c3)C(=O)NCCCCCNC(=O)CS 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 D01 compound treatment 494330.0 52300.0 0.26 491960.0 76800.0 0.36 0.4403 0.9873 3052926 PK04_100065 C[N+](C)(C)CCCC[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3ccc(O)cc3)C(=O)OCCOc4ccc(cc4)[C@@H]5N6[C@H]([C@H](C(=O)OCC=C)[C@@]57C(=O)Nc8ccccc87)C(=O)O[C@H]([C@H]6c9ccccc9)c%10ccccc%10 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 D02 compound treatment 343060.0 -98900.0 -0.49 502750.0 87600.0 0.41 -0.058 -0.0901 3176201 PK04_100066 OCCOc1cccc(c1)[C@@H]2[C@@H](C[C@H]3N2C(=O)[C@@H]4CCCN4C3=O)C(=O)OCCOc5ccc(cc5)[C@H]6N7[C@@H]([C@@H](C(=O)OCC=C)[C@]68C(=O)Nc9ccc(I)cc98)C(=O)O[C@@H]([C@@H]7c%10ccccc%10)c%11ccccc%11 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 D03 compound treatment 485790.0 43800.0 0.22 493200.0 78100.0 0.37 0.4143 0.9693 3052885 PK04_100067 CN(C)CCCC[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3ccc(O)cc3)C(=O)OCCOc4ccc(cc4)[C@@H]5N6[C@H]([C@H](C(=O)OCC=C)[C@@]57C(=O)Nc8ccccc87)C(=O)O[C@H]([C@H]6c9ccccc9)c%10ccccc%10 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 D04 compound treatment 438240.0 -3760.0 -0.02 304200.0 -111000.0 -0.52 -0.3822 -0.7321 3176377 PK04_100068 C[N+](C)(C)CCCC[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3cccc(OCCO)c3)C(=O)OCCOc4ccc(cc4)[C@H]5N6[C@@H]([C@@H](C(=O)OCC=C)[C@]57C(=O)Nc8ccc(I)cc87)C(=O)O[C@@H]([C@@H]6c9ccccc9)c%10ccccc%10 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 D05 compound treatment 301340.0 -141000.0 -0.7 499800.0 84700.0 0.4 -0.2152 -0.2664 3052790 PK04_100069 CC(C)C[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3ccc(O)cc3)C(=O)OCCOc4ccc(cc4)[C@@H]5N6[C@H]([C@H](C(=O)OCC=C)[C@@]57C(=O)Nc8ccccc87)C(=O)O[C@H]([C@H]6c9ccccc9)c%10ccccc%10 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 D06 compound treatment 555400.0 113000.0 0.57 414560.0 -570.0 0.0 0.3986 0.7038 3052881 PK04_100070 CN(C)CCCC[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3ccc(O)cc3)C(=O)NCCCCCCNC(=O)CS 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 D07 compound treatment 412570.0 -29400.0 -0.15 494720.0 79600.0 0.37 0.1608 0.3998 3052536 PK04_100071 CC(=O)NCCCC[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3cccc(OCCO)c3)C(=O)OCCOc4ccc(cc4)[C@@H]5N6[C@H]([C@H](C(=O)OCC=C)[C@@]57C(=O)Nc8ccccc87)C(=O)O[C@H]([C@H]6c9ccccc9)c%10ccccc%10 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 D08 compound treatment 432200.0 -9800.0 -0.05 463740.0 48600.0 0.23 0.1271 0.5434 3052923 PK04_100072 C[N+](C)(C)CCCC[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3ccc(O)cc3)C(=O)NCCCCCCNC(=O)CS 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 D09 compound treatment 535200.0 93200.0 0.47 542750.0 128000.0 0.6 0.7536 0.9921 3052690 PK04_100073 CN(C)CCCC[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3cccc(OCCO)c3)C(=O)NCCCCCCN 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 D10 compound treatment 499280.0 57300.0 0.29 510720.0 95600.0 0.45 0.5202 0.9762 3052841 PK04_100074 CN(C)CCCCCCNC(=O)[C@@H]1C[C@H]2N([C@@H]1c3ccc(O)cc3)C(=O)CNC2=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 D11 mock treatment 534350.0 92300.0 0.46 534160.0 119000.0 0.56 0.722 0.9954 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 D12 mock treatment 559240.0 117000.0 0.59 279220.0 -136000.0 -0.64 -0.038 -0.0438 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 D13 compound treatment 523690.0 81700.0 0.41 560160.0 145000.0 0.68 0.7709 0.9698 3176624 PK04_100075 NCCCCCCNC(=O)[C@H]1C[C@@H]2N([C@H]1c3ccc(O)cc3)C(=O)[C@@H]4CCCN4C2=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 D14 compound treatment 442780.0 779.0 0.0 270560.0 -145000.0 -0.68 -0.4781 -0.703 3176375 PK04_100076 C[N+](C)(C)CCCC[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3cccc(OCCO)c3)C(=O)OCCOc4ccc(cc4)[C@@H]5N6[C@H]([C@H](C(=O)OCC=C)[C@@]57C(=O)Nc8ccc(I)cc87)C(=O)O[C@H]([C@H]6c9ccccc9)c%10ccccc%10 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 D15 mock treatment 465230.0 23200.0 0.12 515130.0 100000.0 0.47 0.4146 0.8559 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 D16 mock treatment 495300.0 53300.0 0.27 591680.0 177000.0 0.83 0.7754 0.8892 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 D17 compound treatment 506770.0 64800.0 0.32 540070.0 125000.0 0.59 0.6443 0.9604 3176503 PK04_100077 CC(C)C[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3ccc(O)cc3)C(=O)NCCCCCCN 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 D18 compound treatment 393370.0 -48600.0 -0.24 522040.0 107000.0 0.5 0.1838 0.3292 3052543 PK04_100078 CC(C)C[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3cccc(OCCO)c3)C(=O)NCCCCCNC(=O)CS 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 D19 compound treatment 458990.0 17000.0 0.08 531100.0 116000.0 0.55 0.4457 0.8074 3052538 PK04_100079 CC(C)C[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3cccc(OCCO)c3)C(=O)O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 D20 compound treatment 519740.0 77700.0 0.39 551520.0 136000.0 0.64 0.7282 0.9711 3052705 PK04_100080 C[N+](C)(C)CCCC[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3cccc(OCCO)c3)C(=O)NCCCCCNC(=O)CS 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 D21 compound treatment 510110.0 68100.0 0.34 534920.0 120000.0 0.56 0.639 0.9708 3052691 PK04_100081 CN(C)CCCC[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3cccc(OCCO)c3)C(=O)NCCCCCN 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 D22 compound treatment 477120.0 35100.0 0.18 343470.0 -71700.0 -0.34 -0.1143 -0.3008 3052534 PK04_100082 CC(=O)NCCCC[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3cccc(OCCO)c3)C(=O)NCCCC[N+](C)(C)C 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 D23 compound treatment 348130.0 -93900.0 -0.47 275720.0 -139000.0 -0.66 -0.7952 -0.9865 3176202 PK04_100083 OCCOc1cccc(c1)[C@H]2[C@H](C[C@@H]3N2C(=O)[C@@H]4CCCN4C3=O)C(=O)OCCOc5ccc(cc5)[C@@H]6N7[C@H]([C@H](C(=O)OCC=C)[C@@]68C(=O)Nc9ccccc98)C(=O)O[C@H]([C@H]7c%10ccccc%10)c%11ccccc%11 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 D24 compound treatment 412720.0 -29300.0 -0.15 439930.0 24800.0 0.12 -0.0209 -0.1119 3176197 PK04_100084 C[N+](C)(C)CCCCNC(=O)[C@@H]1C[C@H]2N([C@@H]1c3cccc(OCCO)c3)C(=O)[C@@H]4CCCN4C2=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 E01 mock treatment 271060.0 -171000.0 -0.85 543920.0 129000.0 0.61 -0.1753 -0.1675 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 E02 mock treatment 455130.0 13100.0 0.07 411570.0 -3560.0 -0.02 0.0345 0.5102 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 E03 compound treatment 517360.0 75400.0 0.38 497480.0 82400.0 0.39 0.54 0.9999 3176672 PK04_100085 CN(C)CCCCNC(=O)[C@H]1C[C@@H]2N([C@H]1c3ccc(O)cc3)C(=O)CNC2=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 E04 compound treatment 499270.0 57300.0 0.29 521250.0 106000.0 0.5 0.5552 0.9651 3052883 PK04_100086 C[N+](C)(C)CCCCCCNC(=O)[C@@H]1C[C@H]2N([C@@H]1c3ccc(O)cc3)C(=O)[C@H](CCCC[N+](C)(C)C)NC2=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 E05 compound treatment 415680.0 -26300.0 -0.13 271630.0 -143000.0 -0.67 -0.5702 -0.8292 3176126 PK04_100087 CN(C)CCCCNC(=O)[C@H]1C[C@@H]2N([C@H]1c3cccc(OCCO)c3)C(=O)[C@@H]4CCCN4C2=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 E06 compound treatment 515910.0 73900.0 0.37 180060.0 -235000.0 -1.11 -0.5208 -0.4468 3052533 PK04_100088 CC(=O)NCCCC[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3cccc(OCCO)c3)C(=O)NCCCCCC[N+](C)(C)C 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 E07 compound treatment 513870.0 71900.0 0.36 201620.0 -214000.0 -1.0 -0.4563 -0.4279 3175839 PK04_100089 NCCCC[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3ccc(O)cc3)C(=O)NCc4ccc(F)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 E08 compound treatment 380020.0 -62000.0 -0.31 531240.0 116000.0 0.55 0.1673 0.2665 3052695 PK04_100090 C[N+](C)(C)CCCCCCNC(=O)[C@H]1C[C@@H]2N([C@H]1c3cccc(OCCO)c3)C(=O)[C@H](CCCC[N+](C)(C)C)NC2=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 E09 mock treatment 551120.0 109000.0 0.54 516720.0 102000.0 0.48 0.7233 0.9979 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 E10 mock treatment 526290.0 84300.0 0.42 593760.0 179000.0 0.84 0.8918 0.9489 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 E11 compound treatment 397860.0 -44100.0 -0.22 243210.0 -172000.0 -0.81 -0.7277 -0.8682 3176568 PK04_100091 Oc1ccc(cc1)[C@H]2[C@H](C[C@@H]3N2C(=O)[C@H](Cc4ccccc4)NC3=O)C(=O)OCCOc5ccc(cc5)[C@H]6N7[C@@H]([C@@H](C(=O)OCC=C)[C@]68C(=O)Nc9ccc(I)cc98)C(=O)O[C@@H]([C@@H]7c%10ccccc%10)c%11ccccc%11 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 E12 compound treatment 533870.0 91900.0 0.46 307940.0 -107000.0 -0.5 -0.0321 -0.047 3176044 PK04_100092 CC(C)C[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3cccc(OCCO)c3)C(=O)NCCCC[N+](C)(C)C 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 E13 compound treatment 320580.0 -121000.0 -0.61 263760.0 -151000.0 -0.71 -0.9323 -0.9968 3052753 PK04_100093 CC(=O)NCCCC[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3ccc(O)cc3)C(=O)OCCOc4ccc(cc4)[C@H]5N6[C@@H]([C@@H](C(=O)OCC=C)[C@]57C(=O)Nc8ccc(I)cc87)C(=O)O[C@@H]([C@@H]6c9ccccc9)c%10ccccc%10 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 E14 compound treatment 498450.0 56400.0 0.28 488340.0 73200.0 0.34 0.4429 0.9951 3175962 PK04_100094 CC(=O)NCCCC[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3cccc(OCCO)c3)C(=O)NCCCC[N+](C)(C)C 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 E15 compound treatment 509850.0 67800.0 0.34 546750.0 132000.0 0.62 0.6774 0.9598 3176325 PK04_100095 CN(C)CCCC[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3cccc(OCCO)c3)C(=O)OCCOc4ccc(cc4)[C@@H]5N6[C@H]([C@H](C(=O)OCC=C)[C@@]57C(=O)Nc8ccc(I)cc87)C(=O)O[C@H]([C@H]6c9ccccc9)c%10ccccc%10 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 E16 compound treatment 547680.0 106000.0 0.53 521090.0 106000.0 0.5 0.7256 0.9996 3052542 PK04_100096 CC(C)C[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3cccc(OCCO)c3)C(=O)NCCCCCCNC(=O)CS 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 E17 mock treatment 400860.0 -41100.0 -0.21 384160.0 -31000.0 -0.15 -0.2483 -0.9858 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 E18 mock treatment 527250.0 85200.0 0.43 460100.0 45000.0 0.21 0.4506 0.9479 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 E19 compound treatment 353280.0 -88700.0 -0.44 403520.0 -11600.0 -0.05 -0.3519 -0.7883 3052746 PK04_100097 CC(=O)NCCCC[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3ccc(O)cc3)C(=O)O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 E20 compound treatment 545200.0 103000.0 0.52 540290.0 125000.0 0.59 0.7807 0.9978 3176676 PK04_100098 Oc1ccc(cc1)[C@H]2[C@H](C[C@@H]3N2C(=O)CNC3=O)C(=O)NCc4ccc(F)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 E21 compound treatment 365000.0 -77000.0 -0.38 419530.0 4400.0 0.02 -0.2573 -0.6681 3052756 PK04_100099 CC(C)C[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3ccc(O)cc3)C(=O)O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 E22 compound treatment 514080.0 72100.0 0.36 317820.0 -97300.0 -0.46 -0.0691 -0.1186 3176560 PK04_100100 Oc1ccc(cc1)[C@H]2[C@H](C[C@@H]3N2C(=O)[C@H](Cc4ccccc4)NC3=O)C(=O)NCc5ccc(F)cc5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 E23 compound treatment 548040.0 106000.0 0.53 468060.0 52900.0 0.25 0.5505 0.9407 3052487 PK04_100101 CC(=O)NCCCC[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3cccc(OCCO)c3)C(=O)O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 E24 compound treatment 435150.0 -6850.0 -0.03 478250.0 63100.0 0.3 0.1857 0.6215 3176563 PK04_100102 Oc1ccc(cc1)[C@H]2[C@H](C[C@@H]3N2C(=O)[C@H](Cc4ccccc4)NC3=O)C(=O)NCCCCCNC(=O)CS 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 F01 mock treatment 349410.0 -92600.0 -0.46 351360.0 -63800.0 -0.3 -0.5391 -0.978 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 F02 mock treatment 536290.0 94300.0 0.47 257980.0 -157000.0 -0.74 -0.1897 -0.2164 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 F03 compound treatment 269020.0 -173000.0 -0.86 176550.0 -239000.0 -1.12 -1.4044 -0.9917 3176684 PK04_100103 Oc1ccc(cc1)[C@H]2[C@H](C[C@@H]3N2C(=O)CNC3=O)C(=O)OCCOc4ccc(cc4)[C@@H]5N6[C@H]([C@H](C(=O)OCC=C)[C@@]57C(=O)Nc8ccccc87)C(=O)O[C@H]([C@H]6c9ccccc9)c%10ccccc%10 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 F04 compound treatment 250610.0 -191000.0 -0.96 261800.0 -153000.0 -0.72 -1.1859 -0.9904 3176121 PK04_100104 OCCOc1cccc(c1)[C@@H]2[C@@H](C[C@H]3N2C(=O)[C@H](Cc4ccccc4)NC3=O)C(=O)OCCOc5ccc(cc5)[C@H]6N7[C@@H]([C@@H](C(=O)OCC=C)[C@]68C(=O)Nc9ccc(I)cc98)C(=O)O[C@@H]([C@@H]7c%10ccccc%10)c%11ccccc%11 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 F05 compound treatment 230010.0 -212000.0 -1.06 187860.0 -227000.0 -1.07 -1.5046 -1.0 3176435 PK04_100105 CC(=O)NCCCC[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3ccc(O)cc3)C(=O)O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 F06 compound treatment 388810.0 -53200.0 -0.27 344680.0 -70400.0 -0.33 -0.4222 -0.994 3176627 PK04_100106 Oc1ccc(cc1)[C@@H]2[C@@H](C[C@H]3N2C(=O)[C@@H]4CCCN4C3=O)C(=O)NCCCCCCNC(=O)CS 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 F07 compound treatment 301200.0 -141000.0 -0.7 197220.0 -218000.0 -1.02 -1.222 -0.9831 3176774 PK04_100107 CN(C)CCCC[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3ccc(O)cc3)C(=O)NCCCCCCN 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 F08 compound treatment 308480.0 -134000.0 -0.67 301390.0 -114000.0 -0.53 -0.8498 -0.994 3174822 PK04_100108 CC(=O)NCCCC[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3cccc(OCCO)c3)C(=O)NCCCCCCNC(=O)CS 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 F09 mock treatment 518650.0 76600.0 0.38 216480.0 -199000.0 -0.93 -0.39 -0.3862 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 F10 mock treatment 534560.0 92600.0 0.46 370000.0 -45100.0 -0.21 0.1768 0.3475 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 F11 compound treatment 287650.0 -154000.0 -0.77 383280.0 -31800.0 -0.15 -0.651 -0.829 3176192 PK04_100109 NCCCCCNC(=O)[C@@H]1C[C@H]2N([C@@H]1c3cccc(OCCO)c3)C(=O)[C@H](Cc4ccccc4)NC2=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 F12 compound treatment 508700.0 66700.0 0.33 270040.0 -145000.0 -0.68 -0.247 -0.3253 3052594 PK04_100110 CN(C)CCCCCCNC(=O)[C@@H]1C[C@H]2N([C@@H]1c3cccc(OCCO)c3)C(=O)[C@@H]4CCCN4C2=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 F13 compound treatment 474720.0 32700.0 0.16 352040.0 -63100.0 -0.3 -0.0943 -0.2783 3052748 PK04_100111 CC(=O)NCCCC[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3ccc(O)cc3)C(=O)NCCCCCN 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 F14 compound treatment 440220.0 -1780.0 -0.01 462520.0 47400.0 0.22 0.1513 0.6784 3176567 PK04_100112 Oc1ccc(cc1)[C@@H]2[C@@H](C[C@H]3N2C(=O)[C@H](Cc4ccccc4)NC3=O)C(=O)OCCOc5ccc(cc5)[C@@H]6N7[C@H]([C@H](C(=O)OCC=C)[C@@]68C(=O)Nc9ccc(I)cc98)C(=O)O[C@H]([C@H]7c%10ccccc%10)c%11ccccc%11 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 F15 compound treatment 442140.0 139.0 0.0 312480.0 -103000.0 -0.48 -0.3409 -0.7061 3052759 PK04_100113 CC(C)C[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3ccc(O)cc3)C(=O)NCCCCCN 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 F16 compound treatment 360550.0 -81500.0 -0.41 342560.0 -72600.0 -0.34 -0.529 -0.9962 3176780 PK04_100114 C[N+](C)(C)CCCC[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3ccc(O)cc3)C(=O)OCCOc4ccc(cc4)[C@@H]5N6[C@H]([C@H](C(=O)OCC=C)[C@@]57C(=O)Nc8ccc(I)cc87)C(=O)O[C@H]([C@H]6c9ccccc9)c%10ccccc%10 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 F17 mock treatment 571130.0 129000.0 0.64 525390.0 110000.0 0.52 0.8228 0.9942 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 F18 mock treatment 426410.0 -15600.0 -0.08 615760.0 201000.0 0.94 0.6122 0.6466 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 F19 compound treatment 487080.0 45100.0 0.23 510640.0 95500.0 0.45 0.4769 0.949 3176625 PK04_100115 NCCCCCNC(=O)[C@@H]1C[C@H]2N([C@@H]1c3ccc(O)cc3)C(=O)[C@@H]4CCCN4C2=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 F20 compound treatment 506580.0 64600.0 0.32 316360.0 -98800.0 -0.46 -0.1004 -0.1776 3052750 PK04_100116 CC(=O)NCCCC[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3ccc(O)cc3)C(=O)NCCCCCNC(=O)CS 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 F21 compound treatment 372920.0 -69100.0 -0.35 569050.0 154000.0 0.72 0.268 0.3341 3052889 PK04_100117 C[N+](C)(C)CCCC[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3ccc(O)cc3)C(=O)NCCCCCCN 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 F22 compound treatment 317210.0 -125000.0 -0.62 469760.0 54600.0 0.26 -0.259 -0.3842 3052696 PK04_100118 C[N+](C)(C)CCCCNC(=O)[C@@H]1C[C@H]2N([C@@H]1c3cccc(OCCO)c3)C(=O)[C@H](CCCC[N+](C)(C)C)NC2=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 F23 compound treatment 525940.0 83900.0 0.42 504610.0 89500.0 0.42 0.5941 1.0 3176674 PK04_100119 NCCCCCNC(=O)[C@H]1C[C@@H]2N([C@H]1c3ccc(O)cc3)C(=O)CNC2=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 F24 compound treatment 545320.0 103000.0 0.52 252510.0 -163000.0 -0.76 -0.176 -0.1907 3176436 PK04_100120 CN(C)CCCCCCNC(=O)[C@H]1C[C@@H]2N([C@H]1c3ccc(O)cc3)C(=O)[C@H](CCCCNC(=O)C)NC2=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 G01 compound treatment 571910.0 130000.0 0.65 412770.0 -2360.0 -0.01 0.4509 0.6949 3052845 PK04_100121 Oc1ccc(cc1)[C@H]2[C@H](C[C@@H]3N2C(=O)CNC3=O)C(=O)NCCCCCNC(=O)CS 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 G02 compound treatment 505440.0 63400.0 0.32 521280.0 106000.0 0.5 0.5771 0.9759 3052835 PK04_100122 C[N+](C)(C)CCCCCCNC(=O)[C@@H]1C[C@H]2N([C@@H]1c3ccc(O)cc3)C(=O)[C@@H]4CCCN4C2=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 G03 mock treatment 481080.0 39100.0 0.2 446020.0 30900.0 0.15 0.2408 0.9894 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 G04 mock treatment 538430.0 96400.0 0.48 202780.0 -212000.0 -1.0 -0.3657 -0.3298 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 G05 compound treatment 511860.0 69900.0 0.35 372900.0 -42200.0 -0.2 0.1063 0.2647 3176502 PK04_100123 CC(C)C[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3ccc(O)cc3)C(=O)NCCCCN(C)C 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 G06 compound treatment 533030.0 91000.0 0.45 529180.0 114000.0 0.54 0.7008 0.9966 3176265 PK04_100124 C[N+](C)(C)CCCCCCNC(=O)[C@H]1C[C@@H]2N([C@H]1c3cccc(OCCO)c3)C(=O)CNC2=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 G07 compound treatment 403060.0 -38900.0 -0.19 538880.0 124000.0 0.58 0.2741 0.4466 3052742 PK04_100125 NCCCC[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3cccc(OCCO)c3)C(=O)O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 G08 compound treatment 555840.0 114000.0 0.57 174410.0 -241000.0 -1.13 -0.3986 -0.3146 3052639 PK04_100126 C[N+](C)(C)CCCCCCNC(=O)[C@H]1C[C@@H]2N([C@H]1c3cccc(OCCO)c3)C(=O)[C@@H]4CCCN4C2=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 G09 compound treatment 298440.0 -144000.0 -0.72 311220.0 -104000.0 -0.49 -0.8526 -0.9825 3176200 PK04_100127 OCCOc1cccc(c1)[C@H]2[C@H](C[C@@H]3N2C(=O)[C@@H]4CCCN4C3=O)C(=O)OCCOc5ccc(cc5)[C@H]6N7[C@@H]([C@@H](C(=O)OCC=C)[C@]68C(=O)Nc9ccc(I)cc98)C(=O)O[C@@H]([C@@H]7c%10ccccc%10)c%11ccccc%11 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 G10 compound treatment 393250.0 -48800.0 -0.24 289650.0 -125000.0 -0.59 -0.5895 -0.9233 3052650 PK04_100128 C[N+](C)(C)CCCCNC(=O)[C@H]1C[C@@H]2N([C@H]1c3cccc(OCCO)c3)C(=O)CNC2=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 G11 compound treatment 470510.0 28500.0 0.14 520770.0 106000.0 0.5 0.452 0.8745 3176683 PK04_100129 Oc1ccc(cc1)[C@H]2[C@H](C[C@@H]3N2C(=O)CNC3=O)C(=O)OCCOc4ccc(cc4)[C@H]5N6[C@@H]([C@@H](C(=O)OCC=C)[C@]57C(=O)Nc8ccc(I)cc87)C(=O)O[C@@H]([C@@H]6c9ccccc9)c%10ccccc%10 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 G12 compound treatment 547520.0 106000.0 0.53 206900.0 -208000.0 -0.98 -0.3199 -0.2876 3176631 PK04_100130 C[N+](C)(C)CCCCNC(=O)[C@H]1C[C@@H]2N([C@H]1c3ccc(O)cc3)C(=O)[C@@H]4CCCN4C2=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 G13 compound treatment 310170.0 -132000.0 -0.66 436320.0 21200.0 0.1 -0.3951 -0.5933 3176045 PK04_100131 CC(C)C[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3cccc(OCCO)c3)C(=O)OCCOc4ccc(cc4)[C@@H]5N6[C@H]([C@H](C(=O)OCC=C)[C@@]57C(=O)Nc8ccc(I)cc87)C(=O)O[C@H]([C@H]6c9ccccc9)c%10ccccc%10 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 G14 compound treatment 490680.0 48700.0 0.24 596280.0 181000.0 0.85 0.7744 0.874 3176196 PK04_100132 OCCOc1cccc(c1)[C@H]2[C@H](C[C@@H]3N2C(=O)[C@@H]4CCCN4C3=O)C(=O)NCCCCCCNC(=O)CS 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 G15 compound treatment 368030.0 -74000.0 -0.37 516640.0 102000.0 0.48 0.0764 0.1265 3176446 PK04_100133 CC(=O)NCCCC[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3ccc(O)cc3)C(=O)OCCOc4ccc(cc4)[C@@H]5N6[C@H]([C@H](C(=O)OCC=C)[C@@]57C(=O)Nc8ccc(I)cc87)C(=O)O[C@H]([C@H]6c9ccccc9)c%10ccccc%10 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 G16 compound treatment 443520.0 1520.0 0.01 335850.0 -79300.0 -0.37 -0.2583 -0.6926 3052834 PK04_100134 Oc1ccc(cc1)[C@H]2[C@H](C[C@@H]3N2C(=O)[C@@H]4CCCN4C3=O)C(=O)NCCCCCCNC(=O)CS 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 G17 compound treatment 535460.0 93500.0 0.47 594400.0 179000.0 0.84 0.9263 0.9611 3052640 PK04_100135 OCCOc1cccc(c1)[C@H]2[C@H](C[C@@H]3N2C(=O)[C@@H]4CCCN4C3=O)C(=O)OCCOc5ccc(cc5)[C@@H]6N7[C@H]([C@H](C(=O)OCC=C)[C@@]68C(=O)Nc9ccc(I)cc98)C(=O)O[C@H]([C@H]7c%10ccccc%10)c%11ccccc%11 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 G18 compound treatment 523470.0 81500.0 0.41 536320.0 121000.0 0.57 0.6908 0.9863 3176727 PK04_100136 CN(C)CCCC[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3ccc(O)cc3)C(=O)NCCCCCCNC(=O)CS 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 G19 mock treatment 453520.0 11500.0 0.06 514610.0 99500.0 0.47 0.3716 0.7881 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 G20 mock treatment 500030.0 58000.0 0.29 592800.0 178000.0 0.84 0.7959 0.8998 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 G21 compound treatment 591070.0 149000.0 0.74 546000.0 131000.0 0.62 0.9617 0.9955 3176272 PK04_100137 CN(C)CCCC[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3cccc(OCCO)c3)C(=O)O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 G22 compound treatment 518410.0 76400.0 0.38 341670.0 -73500.0 -0.35 0.0255 0.0496 3176261 PK04_100138 OCCOc1cccc(c1)[C@H]2[C@H](C[C@@H]3N2C(=O)CNC3=O)C(=O)NCc4ccc(F)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 G23 compound treatment 500680.0 58700.0 0.29 435040.0 19900.0 0.09 0.2735 0.8888 3176513 PK04_100139 OC(=O)[C@H]1C[C@@H]2N([C@H]1c3ccc(O)cc3)C(=O)[C@H](Cc4ccccc4)NC2=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 G24 compound treatment 549830.0 108000.0 0.54 394200.0 -20900.0 -0.1 0.3112 0.5684 3052924 PK04_100140 C[N+](C)(C)CCCC[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3ccc(O)cc3)C(=O)NCCCCCNC(=O)CS 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 H01 compound treatment 515280.0 73300.0 0.37 237370.0 -178000.0 -0.84 -0.3324 -0.3642 3176557 PK04_100141 NCCCCCCNC(=O)[C@H]1C[C@@H]2N([C@H]1c3ccc(O)cc3)C(=O)[C@H](Cc4ccccc4)NC2=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 H02 compound treatment 547640.0 106000.0 0.53 559520.0 144000.0 0.68 0.8533 0.9922 3052875 PK04_100142 Oc1ccc(cc1)[C@@H]2[C@@H](C[C@H]3N2C(=O)CNC3=O)C(=O)OCCOc4ccc(cc4)[C@H]5N6[C@@H]([C@@H](C(=O)OCC=C)[C@]57C(=O)Nc8ccc(I)cc87)C(=O)O[C@@H]([C@@H]6c9ccccc9)c%10ccccc%10 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 H03 mock treatment 311380.0 -131000.0 -0.65 275760.0 -139000.0 -0.66 -0.9248 -1.0 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 H04 mock treatment 555210.0 113000.0 0.57 500960.0 85800.0 0.4 0.6853 0.9864 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 H05 compound treatment 468590.0 26600.0 0.13 301390.0 -114000.0 -0.53 -0.2844 -0.5159 3052652 PK04_100143 OCCOc1cccc(c1)[C@H]2[C@H](C[C@@H]3N2C(=O)CNC3=O)C(=O)OCCOc4ccc(cc4)[C@@H]5N6[C@H]([C@H](C(=O)OCC=C)[C@@]57C(=O)Nc8ccccc87)C(=O)O[C@H]([C@H]6c9ccccc9)c%10ccccc%10 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 H06 compound treatment 146880.0 -295000.0 -1.47 185020.0 -230000.0 -1.08 -1.8076 -0.9885 3052786 PK04_100144 CC(C)C[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3ccc(O)cc3)C(=O)NCCCCCCNC(=O)CS 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 H07 compound treatment 221280.0 -221000.0 -1.1 210360.0 -205000.0 -0.96 -1.4606 -0.9977 3176328 PK04_100145 CN(C)CCCC[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3cccc(OCCO)c3)C(=O)OCCOc4ccc(cc4)[C@@H]5N6[C@H]([C@H](C(=O)OCC=C)[C@@]57C(=O)Nc8ccccc87)C(=O)O[C@H]([C@H]6c9ccccc9)c%10ccccc%10 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 H08 compound treatment 228960.0 -213000.0 -1.06 553370.0 138000.0 0.65 -0.2926 -0.2346 3176321 PK04_100146 CN(C)CCCC[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3cccc(OCCO)c3)C(=O)NCCCCCCNC(=O)CS 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 H09 compound treatment 443130.0 1130.0 0.01 316800.0 -98300.0 -0.46 -0.3231 -0.6984 3176735 PK04_100147 CN(C)CCCC[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3ccc(O)cc3)C(=O)OCCOc4ccc(cc4)[C@@H]5N6[C@H]([C@H](C(=O)OCC=C)[C@@]57C(=O)Nc8ccccc87)C(=O)O[C@H]([C@H]6c9ccccc9)c%10ccccc%10 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 H10 compound treatment 403570.0 -38400.0 -0.19 165760.0 -249000.0 -1.17 -0.9651 -0.812 3175969 PK04_100148 CC(C)C[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3cccc(OCCO)c3)C(=O)NCCCCCCN(C)C 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 H11 compound treatment 590510.0 149000.0 0.74 570650.0 156000.0 0.73 1.0417 1.0 3176193 PK04_100149 NCCCCCNC(=O)[C@@H]1C[C@H]2N([C@@H]1c3cccc(OCCO)c3)C(=O)[C@@H]4CCCN4C2=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 H12 compound treatment 493140.0 51100.0 0.26 639390.0 224000.0 1.05 0.9265 0.8537 3176050 PK04_100150 CN(C)CCCCCCNC(=O)[C@@H]1C[C@H]2N([C@@H]1c3cccc(OCCO)c3)C(=O)[C@H](Cc4ccccc4)NC2=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 H13 compound treatment 389220.0 -52800.0 -0.26 410690.0 -4440.0 -0.02 -0.2012 -0.7607 3176569 PK04_100151 Oc1ccc(cc1)[C@@H]2[C@@H](C[C@H]3N2C(=O)[C@H](Cc4ccccc4)NC3=O)C(=O)OCCOc5ccc(cc5)[C@@H]6N7[C@H]([C@H](C(=O)OCC=C)[C@@]68C(=O)Nc9ccccc98)C(=O)O[C@H]([C@H]7c%10ccccc%10)c%11ccccc%11 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 H14 compound treatment 264020.0 -178000.0 -0.89 379400.0 -35700.0 -0.17 -0.7474 -0.8262 3052874 PK04_100152 Oc1ccc(cc1)[C@@H]2[C@@H](C[C@H]3N2C(=O)CNC3=O)C(=O)OCCOc4ccc(cc4)[C@@H]5N6[C@H]([C@H](C(=O)OCC=C)[C@@]57C(=O)Nc8ccc(I)cc87)C(=O)O[C@H]([C@H]6c9ccccc9)c%10ccccc%10 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 H15 compound treatment 568690.0 127000.0 0.63 389440.0 -25700.0 -0.12 0.362 0.5619 3052832 PK04_100153 NCCCCCNC(=O)[C@H]1C[C@@H]2N([C@H]1c3ccc(O)cc3)C(=O)[C@@H]4CCCN4C2=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 H16 compound treatment 390890.0 -51100.0 -0.26 413830.0 -1300.0 -0.01 -0.1848 -0.7238 3176267 PK04_100154 OCCOc1cccc(c1)[C@@H]2[C@@H](C[C@H]3N2C(=O)CNC3=O)C(=O)OCCOc4ccc(cc4)[C@@H]5N6[C@H]([C@H](C(=O)OCC=C)[C@@]57C(=O)Nc8ccc(I)cc87)C(=O)O[C@H]([C@H]6c9ccccc9)c%10ccccc%10 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 H17 compound treatment 363130.0 -78900.0 -0.39 275840.0 -139000.0 -0.66 -0.7418 -0.9704 3176378 PK04_100155 C[N+](C)(C)CCCC[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3cccc(OCCO)c3)C(=O)OCCOc4ccc(cc4)[C@@H]5N6[C@H]([C@H](C(=O)OCC=C)[C@@]57C(=O)Nc8ccccc87)C(=O)O[C@H]([C@H]6c9ccccc9)c%10ccccc%10 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 H18 compound treatment 537550.0 95500.0 0.48 543160.0 128000.0 0.6 0.7633 0.9934 3176322 PK04_100156 CN(C)CCCC[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3cccc(OCCO)c3)C(=O)NCCCCCNC(=O)CS 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 H19 mock treatment 311080.0 -131000.0 -0.65 378080.0 -37000.0 -0.17 -0.5856 -0.8654 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 H20 mock treatment 331160.0 -111000.0 -0.55 555330.0 140000.0 0.66 0.0749 0.0869 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 H21 compound treatment 349720.0 -92300.0 -0.46 373480.0 -41600.0 -0.2 -0.4644 -0.9274 3052801 PK04_100157 Oc1ccc(cc1)[C@H]2[C@H](C[C@@H]3N2C(=O)[C@H](Cc4ccccc4)NC3=O)C(=O)OCCOc5ccc(cc5)[C@@H]6N7[C@H]([C@H](C(=O)OCC=C)[C@@]68C(=O)Nc9ccccc98)C(=O)O[C@H]([C@H]7c%10ccccc%10)c%11ccccc%11 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 H22 compound treatment 534310.0 92300.0 0.46 355550.0 -59600.0 -0.28 0.1278 0.237 3176726 PK04_100158 CN(C)CCCC[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3ccc(O)cc3)C(=O)NCc4ccc(F)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 H23 compound treatment 285500.0 -157000.0 -0.78 235550.0 -180000.0 -0.84 -1.15 -0.9992 3176558 PK04_100159 NCCCCCCNC(=O)[C@@H]1C[C@H]2N([C@@H]1c3ccc(O)cc3)C(=O)[C@H](Cc4ccccc4)NC2=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 H24 compound treatment 431550.0 -10500.0 -0.05 447840.0 32700.0 0.15 0.0719 0.4425 3052704 PK04_100160 C[N+](C)(C)CCCC[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3cccc(OCCO)c3)C(=O)NCc4ccc(F)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 I01 compound treatment 420640.0 -21400.0 -0.11 535740.0 121000.0 0.57 0.3257 0.5642 3052648 PK04_100161 OCCOc1cccc(c1)[C@H]2[C@H](C[C@@H]3N2C(=O)CNC3=O)C(=O)NCCCCCNC(=O)CS 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 I02 compound treatment 543210.0 101000.0 0.51 504480.0 89400.0 0.42 0.6546 0.9958 3176506 PK04_100162 CC(C)C[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3ccc(O)cc3)C(=O)NCCCCCC[N+](C)(C)C 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 I03 compound treatment 338320.0 -104000.0 -0.52 463560.0 48400.0 0.23 -0.2051 -0.3625 3176274 PK04_100163 CN(C)CCCCNC(=O)[C@H]1C[C@@H]2N([C@H]1c3cccc(OCCO)c3)C(=O)[C@H](CCCCN(C)C)NC2=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 I04 compound treatment 221120.0 -221000.0 -1.1 536160.0 121000.0 0.57 -0.3775 -0.3041 3176679 PK04_100164 C[N+](C)(C)CCCCCCNC(=O)[C@@H]1C[C@H]2N([C@@H]1c3ccc(O)cc3)C(=O)CNC2=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 I05 mock treatment 248060.0 -194000.0 -0.97 198320.0 -217000.0 -1.02 -1.406 -0.9997 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 I06 mock treatment 615320.0 173000.0 0.87 245810.0 -169000.0 -0.8 0.0489 0.0416 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 I07 compound treatment 264350.0 -178000.0 -0.89 407450.0 -7680.0 -0.04 -0.6529 -0.7353 3052930 PK04_100165 NCCCCCNC(=O)[C@@H]1C[C@H]2N([C@@H]1c3ccc(O)cc3)C(=O)[C@H](CCCCN)NC2=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 I08 compound treatment 175680.0 -266000.0 -1.33 217480.0 -198000.0 -0.93 -1.5979 -0.9847 3176444 PK04_100166 CC(=O)NCCCC[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3ccc(O)cc3)C(=O)NCCCCCC[N+](C)(C)C 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 I09 compound treatment 328080.0 -114000.0 -0.57 553440.0 138000.0 0.65 0.0577 0.0667 3052697 PK04_100167 CN(C)CCCC[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3cccc(OCCO)c3)C(=O)OCCOc4ccc(cc4)[C@H]5N6[C@@H]([C@@H](C(=O)OCC=C)[C@]57C(=O)Nc8ccc(I)cc87)C(=O)O[C@@H]([C@@H]6c9ccccc9)c%10ccccc%10 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 I10 compound treatment 471200.0 29200.0 0.15 163580.0 -252000.0 -1.18 -0.7335 -0.6153 3176731 PK04_100168 C[N+](C)(C)CCCCNC(=O)[C@H]1C[C@@H]2N([C@H]1c3ccc(O)cc3)C(=O)[C@H](CCCC[N+](C)(C)C)NC2=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 I11 compound treatment 570960.0 129000.0 0.64 534570.0 119000.0 0.56 0.8527 0.9977 3052535 PK04_100169 CC(=O)NCCCC[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3cccc(OCCO)c3)C(=O)OCCOc4ccc(cc4)[C@H]5N6[C@@H]([C@@H](C(=O)OCC=C)[C@]57C(=O)Nc8ccc(I)cc87)C(=O)O[C@@H]([C@@H]6c9ccccc9)c%10ccccc%10 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 I12 compound treatment 307070.0 -135000.0 -0.67 532260.0 117000.0 0.55 -0.087 -0.0999 3176198 PK04_100170 C[N+](C)(C)CCCCNC(=O)[C@H]1C[C@@H]2N([C@H]1c3cccc(OCCO)c3)C(=O)[C@@H]4CCCN4C2=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 I13 compound treatment 503040.0 61000.0 0.3 566030.0 151000.0 0.71 0.7175 0.9288 3176119 PK04_100171 OCCOc1cccc(c1)[C@H]2[C@H](C[C@@H]3N2C(=O)[C@H](Cc4ccccc4)NC3=O)C(=O)OCCOc5ccc(cc5)[C@@H]6N7[C@H]([C@H](C(=O)OCC=C)[C@@]68C(=O)Nc9ccc(I)cc98)C(=O)O[C@H]([C@H]7c%10ccccc%10)c%11ccccc%11 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 I14 compound treatment 385410.0 -56600.0 -0.28 560710.0 146000.0 0.68 0.2843 0.3838 3176442 PK04_100172 CC(=O)NCCCC[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3ccc(O)cc3)C(=O)NCCCCCCNC(=O)CS 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 I15 compound treatment 454200.0 12200.0 0.06 378840.0 -36300.0 -0.17 -0.0776 -0.4282 3176566 PK04_100173 Oc1ccc(cc1)[C@H]2[C@H](C[C@@H]3N2C(=O)[C@H](Cc4ccccc4)NC3=O)C(=O)OCCOc5ccc(cc5)[C@@H]6N7[C@H]([C@H](C(=O)OCC=C)[C@@]68C(=O)Nc9ccc(I)cc98)C(=O)O[C@H]([C@H]7c%10ccccc%10)c%11ccccc%11 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 I16 compound treatment 554080.0 112000.0 0.56 542930.0 128000.0 0.6 0.8209 0.9994 3052844 PK04_100174 Oc1ccc(cc1)[C@H]2[C@H](C[C@@H]3N2C(=O)CNC3=O)C(=O)NCCCCCCNC(=O)CS 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 I17 compound treatment 501070.0 59100.0 0.3 595520.0 180000.0 0.85 0.8086 0.9001 3176781 PK04_100175 C[N+](C)(C)CCCC[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3ccc(O)cc3)C(=O)OCCOc4ccc(cc4)[C@@H]5N6[C@H]([C@H](C(=O)OCC=C)[C@@]57C(=O)Nc8ccc(I)cc87)C(=O)O[C@H]([C@H]6c9ccccc9)c%10ccccc%10 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 I18 compound treatment 440040.0 -1960.0 -0.01 584330.0 169000.0 0.8 0.5558 0.6984 3052891 PK04_100176 C[N+](C)(C)CCCC[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3ccc(O)cc3)C(=O)NCCCCCCNC(=O)CS 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 I19 compound treatment 446350.0 4350.0 0.02 586600.0 171000.0 0.81 0.5857 0.7259 3052840 PK04_100177 OC(=O)[C@@H]1C[C@H]2N([C@@H]1c3ccc(O)cc3)C(=O)CNC2=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 I20 compound treatment 491780.0 49800.0 0.25 248370.0 -167000.0 -0.78 -0.3788 -0.4604 3174821 PK04_100178 CC(=O)NCCCC[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3cccc(OCCO)c3)C(=O)NCc4ccc(F)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 I21 mock treatment 414110.0 -27900.0 -0.14 563920.0 149000.0 0.7 0.3964 0.5555 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 I22 mock treatment 561760.0 120000.0 0.6 589280.0 174000.0 0.82 1.0022 0.9881 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 I23 compound treatment 557460.0 115000.0 0.58 565690.0 151000.0 0.71 0.9085 0.9948 3176670 PK04_100179 OC(=O)[C@H]1C[C@@H]2N([C@H]1c3ccc(O)cc3)C(=O)[C@@H]4CCCN4C2=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 I24 compound treatment 539760.0 97800.0 0.49 546090.0 131000.0 0.62 0.7808 0.9934 3176728 PK04_100180 CN(C)CCCC[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3ccc(O)cc3)C(=O)NCCCCCNC(=O)CS 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 J01 compound treatment 573150.0 131000.0 0.66 279840.0 -135000.0 -0.64 0.0132 0.0145 3176783 PK04_100181 C[N+](C)(C)CCCC[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3ccc(O)cc3)C(=O)OCCOc4ccc(cc4)[C@@H]5N6[C@H]([C@H](C(=O)OCC=C)[C@@]57C(=O)Nc8ccccc87)C(=O)O[C@H]([C@H]6c9ccccc9)c%10ccccc%10 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 J02 compound treatment 411920.0 -30100.0 -0.15 371110.0 -44000.0 -0.21 -0.2526 -0.9876 3176448 PK04_100182 CC(=O)NCCCC[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3ccc(O)cc3)C(=O)OCCOc4ccc(cc4)[C@H]5N6[C@@H]([C@@H](C(=O)OCC=C)[C@]57C(=O)Nc8ccc(I)cc87)C(=O)O[C@@H]([C@@H]6c9ccccc9)c%10ccccc%10 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 J03 compound treatment 293000.0 -149000.0 -0.74 283690.0 -131000.0 -0.62 -0.9634 -0.9958 3176047 PK04_100183 CC(C)C[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3cccc(OCCO)c3)C(=O)OCCOc4ccc(cc4)[C@@H]5N6[C@H]([C@H](C(=O)OCC=C)[C@@]57C(=O)Nc8ccccc87)C(=O)O[C@H]([C@H]6c9ccccc9)c%10ccccc%10 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 J04 compound treatment 206560.0 -235000.0 -1.18 249810.0 -165000.0 -0.78 -1.3813 -0.9798 3176269 PK04_100184 OCCOc1cccc(c1)[C@@H]2[C@@H](C[C@H]3N2C(=O)CNC3=O)C(=O)OCCOc4ccc(cc4)[C@H]5N6[C@@H]([C@@H](C(=O)OCC=C)[C@]57C(=O)Nc8ccc(I)cc87)C(=O)O[C@@H]([C@@H]6c9ccccc9)c%10ccccc%10 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 J05 mock treatment 543200.0 101000.0 0.51 332330.0 -82800.0 -0.39 0.082 0.1285 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 J06 mock treatment 255260.0 -187000.0 -0.93 182460.0 -233000.0 -1.09 -1.4334 -0.9968 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 J07 compound treatment 275110.0 -167000.0 -0.83 476480.0 61400.0 0.29 -0.3853 -0.4369 3176635 PK04_100185 Oc1ccc(cc1)[C@H]2[C@H](C[C@@H]3N2C(=O)[C@@H]4CCCN4C3=O)C(=O)OCCOc5ccc(cc5)[C@@H]6N7[C@H]([C@H](C(=O)OCC=C)[C@@]68C(=O)Nc9ccccc98)C(=O)O[C@H]([C@H]7c%10ccccc%10)c%11ccccc%11 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 J08 compound treatment 430130.0 -11900.0 -0.06 258510.0 -157000.0 -0.74 -0.5628 -0.7616 3176114 PK04_100186 OCCOc1cccc(c1)[C@@H]2[C@@H](C[C@H]3N2C(=O)[C@H](Cc4ccccc4)NC3=O)C(=O)NCCCCCCNC(=O)CS 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 J09 compound treatment 511780.0 69800.0 0.35 558810.0 144000.0 0.68 0.7243 0.9526 3175966 PK04_100187 CC(=O)NCCCC[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3cccc(OCCO)c3)C(=O)OCCOc4ccc(cc4)[C@@H]5N6[C@H]([C@H](C(=O)OCC=C)[C@@]57C(=O)Nc8ccccc87)C(=O)O[C@H]([C@H]6c9ccccc9)c%10ccccc%10 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 J10 compound treatment 177520.0 -264000.0 -1.32 189600.0 -226000.0 -1.06 -1.6842 -0.9941 3052757 PK04_100188 CC(C)C[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3ccc(O)cc3)C(=O)NCCCCCCN(C)C 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 J11 compound treatment 519640.0 77600.0 0.39 548390.0 133000.0 0.63 0.7174 0.9733 3174819 PK04_100189 CC(=O)NCCCC[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3cccc(OCCO)c3)C(=O)NCCCCCCN 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 J12 compound treatment 444050.0 2050.0 0.01 281050.0 -134000.0 -0.63 -0.4387 -0.6955 3176738 PK04_100190 CN(C)CCCCCCNC(=O)[C@@H]1C[C@H]2N([C@@H]1c3ccc(O)cc3)C(=O)[C@H](CCCC[N+](C)(C)C)NC2=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 J13 compound treatment 561890.0 120000.0 0.6 542240.0 127000.0 0.6 0.8462 1.0 3176380 PK04_100191 CN(C)CCCCCCNC(=O)[C@H]1C[C@@H]2N([C@H]1c3cccc(OCCO)c3)C(=O)[C@H](CCCCN)NC2=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 J14 compound treatment 420220.0 -21800.0 -0.11 497760.0 82600.0 0.39 0.1979 0.4903 3176199 PK04_100192 OCCOc1cccc(c1)[C@@H]2[C@@H](C[C@H]3N2C(=O)[C@@H]4CCCN4C3=O)C(=O)OCCOc5ccc(cc5)[C@@H]6N7[C@H]([C@H](C(=O)OCC=C)[C@@]68C(=O)Nc9ccc(I)cc98)C(=O)O[C@H]([C@H]7c%10ccccc%10)c%11ccccc%11 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 J15 compound treatment 458830.0 16800.0 0.08 547940.0 133000.0 0.62 0.5012 0.7951 3176623 PK04_100193 NCCCCCCNC(=O)[C@@H]1C[C@H]2N([C@@H]1c3ccc(O)cc3)C(=O)[C@@H]4CCCN4C2=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 J16 compound treatment 411260.0 -30700.0 -0.15 404500.0 -10600.0 -0.05 -0.1439 -0.8913 3176632 PK04_100194 Oc1ccc(cc1)[C@@H]2[C@@H](C[C@H]3N2C(=O)[C@@H]4CCCN4C3=O)C(=O)OCCOc5ccc(cc5)[C@@H]6N7[C@H]([C@H](C(=O)OCC=C)[C@@]68C(=O)Nc9ccc(I)cc98)C(=O)O[C@H]([C@H]7c%10ccccc%10)c%11ccccc%11 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 J17 compound treatment 423680.0 -18300.0 -0.09 455520.0 40400.0 0.19 0.0696 0.3302 3052795 PK04_100195 NCCCCCNC(=O)[C@@H]1C[C@H]2N([C@@H]1c3ccc(O)cc3)C(=O)[C@H](Cc4ccccc4)NC2=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 J18 compound treatment 525770.0 83800.0 0.42 447370.0 32200.0 0.15 0.4031 0.9057 3052636 PK04_100196 OCCOc1cccc(c1)[C@@H]2[C@@H](C[C@H]3N2C(=O)[C@@H]4CCCN4C3=O)C(=O)NCCCCCNC(=O)CS 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 J19 compound treatment 490400.0 48400.0 0.24 364760.0 -50400.0 -0.24 0.0034 0.01 3052591 PK04_100197 OCCOc1cccc(c1)[C@@H]2[C@@H](C[C@H]3N2C(=O)[C@H](Cc4ccccc4)NC3=O)C(=O)OCCOc5ccc(cc5)[C@@H]6N7[C@H]([C@H](C(=O)OCC=C)[C@@]68C(=O)Nc9ccccc98)C(=O)O[C@H]([C@H]7c%10ccccc%10)c%11ccccc%11 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 J20 compound treatment 409470.0 -32500.0 -0.16 452890.0 37800.0 0.18 0.0107 0.0445 3176629 PK04_100198 Oc1ccc(cc1)[C@@H]2[C@@H](C[C@H]3N2C(=O)[C@@H]4CCCN4C3=O)C(=O)NCCCCCNC(=O)CS 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 J21 mock treatment 436350.0 -5650.0 -0.03 404420.0 -10700.0 -0.05 -0.0556 -0.9625 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 J22 mock treatment 440500.0 -1500.0 -0.01 345810.0 -69300.0 -0.33 -0.2359 -0.7232 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 J23 compound treatment 577820.0 136000.0 0.68 279100.0 -136000.0 -0.64 0.0272 0.0292 3176776 PK04_100199 C[N+](C)(C)CCCC[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3ccc(O)cc3)C(=O)NCCCCCN 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 J24 compound treatment 262290.0 -180000.0 -0.9 322740.0 -92400.0 -0.43 -0.942 -0.9446 3052544 PK04_100200 CC(C)C[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3cccc(OCCO)c3)C(=O)NCCCC[N+](C)(C)C 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 K01 compound treatment 393610.0 -48400.0 -0.24 575730.0 161000.0 0.76 0.3633 0.458 3176739 PK04_100201 CN(C)CCCCNC(=O)[C@H]1C[C@@H]2N([C@H]1c3ccc(O)cc3)C(=O)[C@H](CCCC[N+](C)(C)C)NC2=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 K02 compound treatment 549890.0 108000.0 0.54 517850.0 103000.0 0.48 0.7227 0.9985 3176042 PK04_100202 CC(C)C[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3cccc(OCCO)c3)C(=O)NCCCCCC[N+](C)(C)C 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 K03 compound treatment 551360.0 109000.0 0.55 240690.0 -174000.0 -0.82 -0.194 -0.1968 3052528 PK04_100203 CN(C)CCCCNC(=O)[C@H]1C[C@@H]2N([C@H]1c3cccc(OCCO)c3)C(=O)[C@H](CCCCNC(=O)C)NC2=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 K04 compound treatment 212360.0 -230000.0 -1.15 191360.0 -224000.0 -1.05 -1.5553 -0.9991 3176564 PK04_100204 C[N+](C)(C)CCCCCCNC(=O)[C@@H]1C[C@H]2N([C@@H]1c3ccc(O)cc3)C(=O)[C@H](Cc4ccccc4)NC2=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 K05 compound treatment 184240.0 -258000.0 -1.29 228660.0 -186000.0 -0.88 -1.5305 -0.9825 3176329 PK04_100205 CN(C)CCCC[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3cccc(OCCO)c3)C(=O)OCCOc4ccc(cc4)[C@H]5N6[C@@H]([C@@H](C(=O)OCC=C)[C@]57C(=O)Nc8ccccc87)C(=O)O[C@@H]([C@@H]6c9ccccc9)c%10ccccc%10 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 K06 compound treatment 187070.0 -255000.0 -1.27 218640.0 -196000.0 -0.92 -1.5538 -0.9876 3052588 PK04_100206 C[N+](C)(C)CCCCCCNC(=O)[C@H]1C[C@@H]2N([C@H]1c3cccc(OCCO)c3)C(=O)[C@H](Cc4ccccc4)NC2=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 K07 mock treatment 561920.0 120000.0 0.6 208970.0 -206000.0 -0.97 -0.2622 -0.23 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 K08 mock treatment 565410.0 123000.0 0.62 234100.0 -181000.0 -0.85 -0.1663 -0.1582 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 K09 compound treatment 235220.0 -207000.0 -1.03 358830.0 -56300.0 -0.26 -0.9175 -0.8606 3176733 PK04_100207 CN(C)CCCC[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3ccc(O)cc3)C(=O)OCCOc4ccc(cc4)[C@H]5N6[C@@H]([C@@H](C(=O)OCC=C)[C@]57C(=O)Nc8ccc(I)cc87)C(=O)O[C@@H]([C@@H]6c9ccccc9)c%10ccccc%10 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 K10 compound treatment 170720.0 -271000.0 -1.35 519480.0 104000.0 0.49 -0.611 -0.424 3052589 PK04_100208 C[N+](C)(C)CCCCNC(=O)[C@H]1C[C@@H]2N([C@H]1c3cccc(OCCO)c3)C(=O)[C@H](Cc4ccccc4)NC2=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 K11 compound treatment 541300.0 99300.0 0.5 377530.0 -37600.0 -0.18 0.2256 0.4285 3052651 PK04_100209 OCCOc1cccc(c1)[C@H]2[C@H](C[C@@H]3N2C(=O)CNC3=O)C(=O)OCCOc4ccc(cc4)[C@H]5N6[C@@H]([C@@H](C(=O)OCC=C)[C@]57C(=O)Nc8ccc(I)cc87)C(=O)O[C@@H]([C@@H]6c9ccccc9)c%10ccccc%10 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 K12 compound treatment 531840.0 89800.0 0.45 278930.0 -136000.0 -0.64 -0.1357 -0.1735 3176507 PK04_100210 CC(C)C[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3ccc(O)cc3)C(=O)NCCCC[N+](C)(C)C 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 K13 compound treatment 568330.0 126000.0 0.63 507680.0 92600.0 0.44 0.754 0.9836 3052706 PK04_100211 C[N+](C)(C)CCCC[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3cccc(OCCO)c3)C(=O)OCCOc4ccc(cc4)[C@@H]5N6[C@H]([C@H](C(=O)OCC=C)[C@@]57C(=O)Nc8ccc(I)cc87)C(=O)O[C@H]([C@H]6c9ccccc9)c%10ccccc%10 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 K14 compound treatment 574810.0 133000.0 0.66 594880.0 180000.0 0.85 1.0669 0.9928 3175959 PK04_100212 CC(=O)NCCCC[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3cccc(OCCO)c3)C(=O)NCCCCCCNC(=O)CS 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 K15 mock treatment 546970.0 105000.0 0.52 577610.0 162000.0 0.76 0.9111 0.9831 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 K16 mock treatment 636880.0 195000.0 0.97 613440.0 198000.0 0.93 1.3478 0.9998 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 K17 compound treatment 559800.0 118000.0 0.59 474240.0 59100.0 0.28 0.6126 0.9414 3174817 PK04_100213 CC(=O)NCCCC[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3cccc(OCCO)c3)C(=O)O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 K18 compound treatment 599010.0 157000.0 0.78 648650.0 234000.0 1.1 1.3312 0.9864 3176725 PK04_100214 CN(C)CCCC[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3ccc(O)cc3)C(=O)NCc4ccc(F)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 K19 compound treatment 564200.0 122000.0 0.61 373920.0 -41200.0 -0.19 0.2945 0.4599 3052537 PK04_100215 CC(C)C[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3cccc(OCCO)c3)C(=O)O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 K20 compound treatment 533150.0 91100.0 0.46 325780.0 -89300.0 -0.42 0.0247 0.0399 3052596 PK04_100216 OCCOc1cccc(c1)[C@H]2[C@H](C[C@@H]3N2C(=O)[C@@H]4CCCN4C3=O)C(=O)NCc5ccc(F)cc5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 K21 compound treatment 576450.0 134000.0 0.67 587040.0 172000.0 0.81 1.0466 0.9957 3176049 PK04_100217 OCCOc1cccc(c1)[C@H]2[C@H](C[C@@H]3N2C(=O)[C@H](Cc4ccccc4)NC3=O)C(=O)O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 K22 compound treatment 491710.0 49700.0 0.25 460370.0 45200.0 0.21 0.326 0.9971 3052637 PK04_100218 OCCOc1cccc(c1)[C@H]2[C@H](C[C@@H]3N2C(=O)[C@@H]4CCCN4C3=O)C(=O)NCCCCCNC(=O)CS 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 K23 mock treatment 368120.0 -73900.0 -0.37 629810.0 215000.0 1.01 0.4531 0.4215 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 K24 mock treatment 291040.0 -151000.0 -0.75 379050.0 -36100.0 -0.17 -0.6531 -0.8451 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 L01 compound treatment 548100.0 106000.0 0.53 527270.0 112000.0 0.53 0.7477 1.0 3052595 PK04_100219 NCCCCCCNC(=O)[C@@H]1C[C@H]2N([C@@H]1c3cccc(OCCO)c3)C(=O)[C@@H]4CCCN4C2=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 L02 compound treatment 324810.0 -117000.0 -0.59 269460.0 -146000.0 -0.69 -0.8984 -0.9969 3176046 PK04_100220 CC(C)C[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3cccc(OCCO)c3)C(=O)OCCOc4ccc(cc4)[C@H]5N6[C@@H]([C@@H](C(=O)OCC=C)[C@]57C(=O)Nc8ccc(I)cc87)C(=O)O[C@@H]([C@@H]6c9ccccc9)c%10ccccc%10 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 L03 compound treatment 222910.0 -219000.0 -1.09 516350.0 101000.0 0.48 -0.4371 -0.3663 3052585 PK04_100221 NCCCCCCNC(=O)[C@H]1C[C@@H]2N([C@H]1c3cccc(OCCO)c3)C(=O)[C@H](Cc4ccccc4)NC2=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 L04 compound treatment 504740.0 62700.0 0.31 173400.0 -242000.0 -1.14 -0.5824 -0.4938 3176734 PK04_100222 CN(C)CCCC[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3ccc(O)cc3)C(=O)OCCOc4ccc(cc4)[C@H]5N6[C@@H]([C@@H](C(=O)OCC=C)[C@]57C(=O)Nc8ccc(I)cc87)C(=O)O[C@@H]([C@@H]6c9ccccc9)c%10ccccc%10 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 L05 compound treatment 212650.0 -229000.0 -1.15 582240.0 167000.0 0.79 -0.2542 -0.183 3176688 PK04_100223 CN(C)CCCC[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3ccc(O)cc3)C(=O)NCCCCCCN 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 L06 compound treatment 511690.0 69700.0 0.35 537490.0 122000.0 0.58 0.6531 0.971 3176372 PK04_100224 C[N+](C)(C)CCCC[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3cccc(OCCO)c3)C(=O)NCCCCCCNC(=O)CS 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 L07 mock treatment 253720.0 -188000.0 -0.94 205460.0 -210000.0 -0.99 -1.3623 -0.9997 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 L08 mock treatment 412970.0 -29000.0 -0.14 541600.0 126000.0 0.59 0.3181 0.5195 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 L09 compound treatment 558500.0 116000.0 0.58 218180.0 -197000.0 -0.93 -0.2436 -0.2227 3176559 PK04_100225 NCCCCCNC(=O)[C@H]1C[C@@H]2N([C@H]1c3ccc(O)cc3)C(=O)[C@H](Cc4ccccc4)NC2=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 L10 compound treatment 231580.0 -210000.0 -1.05 408930.0 -6200.0 -0.03 -0.7638 -0.7264 3052527 PK04_100226 CN(C)CCCCCCNC(=O)[C@@H]1C[C@H]2N([C@@H]1c3cccc(OCCO)c3)C(=O)[C@H](CCCCNC(=O)C)NC2=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 L11 compound treatment 549930.0 108000.0 0.54 587640.0 173000.0 0.81 0.9549 0.9803 3176432 PK04_100227 C[N+](C)(C)CCCC[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3cccc(OCCO)c3)C(=O)NCCCCCCN 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 L12 compound treatment 433280.0 -8720.0 -0.04 295170.0 -120000.0 -0.56 -0.4298 -0.7594 3176326 PK04_100228 CN(C)CCCC[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3cccc(OCCO)c3)C(=O)OCCOc4ccc(cc4)[C@@H]5N6[C@H]([C@H](C(=O)OCC=C)[C@@]57C(=O)Nc8ccc(I)cc87)C(=O)O[C@H]([C@H]6c9ccccc9)c%10ccccc%10 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 L13 compound treatment 527050.0 85000.0 0.42 379320.0 -35800.0 -0.17 0.1813 0.3967 3176737 PK04_100229 C[N+](C)(C)CCCC[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3ccc(O)cc3)C(=O)O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 L14 compound treatment 409520.0 -32500.0 -0.16 499380.0 84300.0 0.4 0.1655 0.3865 3175964 PK04_100230 CC(=O)NCCCC[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3cccc(OCCO)c3)C(=O)OCCOc4ccc(cc4)[C@@H]5N6[C@H]([C@H](C(=O)OCC=C)[C@@]57C(=O)Nc8ccc(I)cc87)C(=O)O[C@H]([C@H]6c9ccccc9)c%10ccccc%10 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 L15 mock treatment 325440.0 -117000.0 -0.58 312990.0 -102000.0 -0.48 -0.7514 -0.9954 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 L16 mock treatment 354930.0 -87100.0 -0.43 535530.0 120000.0 0.57 0.0929 0.1302 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 L17 compound treatment 531290.0 89300.0 0.45 619010.0 204000.0 0.96 0.9934 0.9393 3176787 PK04_100231 CN(C)CCCCCCNC(=O)[C@H]1C[C@@H]2N([C@H]1c3ccc(O)cc3)C(=O)[C@H](CCCCN)NC2=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 L18 compound treatment 463270.0 21300.0 0.11 478090.0 63000.0 0.3 0.2845 0.9043 3175960 PK04_100232 CC(=O)NCCCC[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3cccc(OCCO)c3)C(=O)NCCCCCNC(=O)CS 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 L19 compound treatment 302240.0 -140000.0 -0.7 589520.0 174000.0 0.82 0.0864 0.0802 3176273 PK04_100233 CN(C)CCCC[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3cccc(OCCO)c3)C(=O)O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 L20 compound treatment 575300.0 133000.0 0.67 569540.0 154000.0 0.73 0.9843 0.9991 3052882 PK04_100234 CN(C)CCCC[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3ccc(O)cc3)C(=O)NCCCCCNC(=O)CS 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 L21 compound treatment 508160.0 66200.0 0.33 583630.0 169000.0 0.79 0.7941 0.9248 3176053 PK04_100235 NCCCCCNC(=O)[C@H]1C[C@@H]2N([C@H]1c3cccc(OCCO)c3)C(=O)[C@H](Cc4ccccc4)NC2=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 L22 compound treatment 452370.0 10400.0 0.05 529290.0 114000.0 0.54 0.4163 0.7717 3052696 PK04_100236 C[N+](C)(C)CCCCNC(=O)[C@@H]1C[C@H]2N([C@@H]1c3cccc(OCCO)c3)C(=O)[C@H](CCCC[N+](C)(C)C)NC2=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 L23 mock treatment 500420.0 58400.0 0.29 482050.0 66900.0 0.31 0.4289 0.9993 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 L24 mock treatment 557920.0 116000.0 0.58 547040.0 132000.0 0.62 0.8481 0.9994 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 M01 compound treatment 538480.0 96500.0 0.48 550460.0 135000.0 0.64 0.7908 0.9906 3176052 PK04_100237 CN(C)CCCCNC(=O)[C@H]1C[C@@H]2N([C@H]1c3cccc(OCCO)c3)C(=O)[C@H](Cc4ccccc4)NC2=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 M02 compound treatment 572750.0 131000.0 0.65 567520.0 152000.0 0.72 0.9686 0.9989 3176323 PK04_100238 C[N+](C)(C)CCCCCCNC(=O)[C@@H]1C[C@H]2N([C@@H]1c3cccc(OCCO)c3)C(=O)[C@H](CCCC[N+](C)(C)C)NC2=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 M03 compound treatment 566920.0 125000.0 0.62 485360.0 70200.0 0.33 0.6748 0.9558 3176206 PK04_100239 CN(C)CCCCNC(=O)[C@H]1C[C@@H]2N([C@H]1c3cccc(OCCO)c3)C(=O)CNC2=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 M04 compound treatment 579800.0 138000.0 0.69 159540.0 -256000.0 -1.2 -0.3634 -0.2624 3052883 PK04_100240 C[N+](C)(C)CCCCCCNC(=O)[C@@H]1C[C@H]2N([C@@H]1c3ccc(O)cc3)C(=O)[C@H](CCCC[N+](C)(C)C)NC2=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 M05 compound treatment 526560.0 84600.0 0.42 248640.0 -166000.0 -0.78 -0.2551 -0.2867 3052744 PK04_100241 NCCCCCCNC(=O)[C@@H]1C[C@H]2N([C@@H]1c3cccc(OCCO)c3)C(=O)[C@H](CCCCN)NC2=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 M06 compound treatment 345920.0 -96100.0 -0.48 495130.0 80000.0 0.38 -0.0732 -0.1201 3176505 PK04_100242 CC(C)C[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3ccc(O)cc3)C(=O)NCCCCCC[N+](C)(C)C 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 M07 compound treatment 242800.0 -199000.0 -0.99 200380.0 -215000.0 -1.01 -1.4178 -1.0 3176434 PK04_100243 NCCCC[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3cccc(OCCO)c3)C(=O)NCc4ccc(F)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 M08 compound treatment 550560.0 109000.0 0.54 325600.0 -89500.0 -0.42 0.0856 0.1247 3176729 PK04_100244 C[N+](C)(C)CCCCCCNC(=O)[C@H]1C[C@@H]2N([C@H]1c3ccc(O)cc3)C(=O)[C@H](CCCC[N+](C)(C)C)NC2=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 M09 mock treatment 610250.0 168000.0 0.84 358040.0 -57100.0 -0.27 0.4043 0.4583 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 M10 mock treatment 504060.0 62100.0 0.31 405360.0 -9770.0 -0.05 0.1867 0.5958 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 M11 compound treatment 255750.0 -186000.0 -0.93 488840.0 73700.0 0.35 -0.4126 -0.4156 3052590 PK04_100245 OCCOc1cccc(c1)[C@H]2[C@H](C[C@@H]3N2C(=O)[C@H](Cc4ccccc4)NC3=O)C(=O)OCCOc5ccc(cc5)[C@H]6N7[C@@H]([C@@H](C(=O)OCC=C)[C@]68C(=O)Nc9ccc(I)cc98)C(=O)O[C@@H]([C@@H]7c%10ccccc%10)c%11ccccc%11 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 M12 compound treatment 540030.0 98000.0 0.49 206900.0 -208000.0 -0.98 -0.3464 -0.3163 3176565 PK04_100246 C[N+](C)(C)CCCCNC(=O)[C@H]1C[C@@H]2N([C@H]1c3ccc(O)cc3)C(=O)[C@H](Cc4ccccc4)NC2=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 M13 mock treatment 331270.0 -111000.0 -0.55 383960.0 -31200.0 -0.15 -0.4947 -0.8647 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 M14 mock treatment 518680.0 76700.0 0.38 540800.0 126000.0 0.59 0.6888 0.9779 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 M15 compound treatment 424540.0 -17500.0 -0.09 583130.0 168000.0 0.79 0.4971 0.6253 3176508 PK04_100247 CC(C)C[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3ccc(O)cc3)C(=O)OCCOc4ccc(cc4)[C@@H]5N6[C@H]([C@H](C(=O)OCC=C)[C@@]57C(=O)Nc8ccc(I)cc87)C(=O)O[C@H]([C@H]6c9ccccc9)c%10ccccc%10 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 M16 compound treatment 480050.0 38000.0 0.19 526500.0 111000.0 0.52 0.5048 0.9059 3052587 PK04_100248 OCCOc1cccc(c1)[C@H]2[C@H](C[C@@H]3N2C(=O)[C@H](Cc4ccccc4)NC3=O)C(=O)NCCCCCCNC(=O)CS 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 M17 compound treatment 530210.0 88200.0 0.44 519060.0 104000.0 0.49 0.6572 0.9987 3052643 PK04_100249 OCCOc1cccc(c1)[C@@H]2[C@@H](C[C@H]3N2C(=O)CNC3=O)C(=O)O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 M18 compound treatment 516880.0 74900.0 0.37 543580.0 128000.0 0.6 0.6917 0.9734 3176777 PK04_100250 C[N+](C)(C)CCCC[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3ccc(O)cc3)C(=O)NCc4ccc(F)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 M19 compound treatment 543740.0 102000.0 0.51 500320.0 85200.0 0.4 0.6426 0.9931 3052583 PK04_100251 OCCOc1cccc(c1)[C@@H]2[C@@H](C[C@H]3N2C(=O)[C@H](Cc4ccccc4)NC3=O)C(=O)O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 M20 compound treatment 393120.0 -48900.0 -0.24 468880.0 53800.0 0.25 0.0061 0.0175 3052586 PK04_100252 OCCOc1cccc(c1)[C@H]2[C@H](C[C@@H]3N2C(=O)[C@H](Cc4ccccc4)NC3=O)C(=O)NCc5ccc(F)cc5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 M21 compound treatment 586790.0 145000.0 0.72 549970.0 135000.0 0.63 0.9598 0.9979 3052593 PK04_100253 OCCOc1cccc(c1)[C@H]2[C@H](C[C@@H]3N2C(=O)[C@@H]4CCCN4C3=O)C(=O)O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 M22 compound treatment 570590.0 129000.0 0.64 540720.0 126000.0 0.59 0.8718 0.9991 3176374 PK04_100254 C[N+](C)(C)CCCC[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3cccc(OCCO)c3)C(=O)NCCCCCNC(=O)CS 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 M23 compound treatment 313780.0 -128000.0 -0.64 454440.0 39300.0 0.18 -0.3221 -0.4832 3052699 PK04_100255 C[N+](C)(C)CCCC[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3cccc(OCCO)c3)C(=O)O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 M24 compound treatment 363860.0 -78100.0 -0.39 417960.0 2830.0 0.01 -0.2666 -0.6826 3176628 PK04_100256 Oc1ccc(cc1)[C@H]2[C@H](C[C@@H]3N2C(=O)[C@@H]4CCCN4C3=O)C(=O)NCCCCCNC(=O)CS 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 N01 compound treatment 534510.0 92500.0 0.46 510440.0 95300.0 0.45 0.6437 0.9999 3052530 PK04_100257 CC(=O)NCCCC[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3cccc(OCCO)c3)C(=O)NCCCCCN 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 N02 compound treatment 438630.0 -3370.0 -0.02 284000.0 -131000.0 -0.62 -0.448 -0.7261 3176510 PK04_100258 CC(C)C[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3ccc(O)cc3)C(=O)OCCOc4ccc(cc4)[C@H]5N6[C@@H]([C@@H](C(=O)OCC=C)[C@]57C(=O)Nc8ccc(I)cc87)C(=O)O[C@@H]([C@@H]6c9ccccc9)c%10ccccc%10 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 N03 compound treatment 393190.0 -48800.0 -0.24 482400.0 67300.0 0.32 0.0514 0.1286 3052646 PK04_100259 NCCCCCNC(=O)[C@H]1C[C@@H]2N([C@H]1c3cccc(OCCO)c3)C(=O)CNC2=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 N04 compound treatment 177530.0 -264000.0 -1.32 151360.0 -264000.0 -1.24 -1.8113 -0.9995 3176040 PK04_100260 CC(C)C[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3cccc(OCCO)c3)C(=O)NCCCCCCNC(=O)CS 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 N05 compound treatment 241020.0 -201000.0 -1.0 249730.0 -165000.0 -0.78 -1.2599 -0.9921 3052838 PK04_100261 Oc1ccc(cc1)[C@@H]2[C@@H](C[C@H]3N2C(=O)[C@@H]4CCCN4C3=O)C(=O)OCCOc5ccc(cc5)[C@@H]6N7[C@H]([C@H](C(=O)OCC=C)[C@@]68C(=O)Nc9ccccc98)C(=O)O[C@H]([C@H]7c%10ccccc%10)c%11ccccc%11 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 N06 compound treatment 230200.0 -212000.0 -1.06 174570.0 -241000.0 -1.13 -1.5481 -0.9994 3176263 PK04_100262 OCCOc1cccc(c1)[C@@H]2[C@@H](C[C@H]3N2C(=O)CNC3=O)C(=O)NCCCCCCNC(=O)CS 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 N07 compound treatment 306570.0 -135000.0 -0.68 339910.0 -75200.0 -0.35 -0.7285 -0.9543 3176511 PK04_100263 CC(C)C[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3ccc(O)cc3)C(=O)OCCOc4ccc(cc4)[C@@H]5N6[C@H]([C@H](C(=O)OCC=C)[C@@]57C(=O)Nc8ccccc87)C(=O)O[C@H]([C@H]6c9ccccc9)c%10ccccc%10 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 N08 compound treatment 353370.0 -88600.0 -0.44 297080.0 -118000.0 -0.56 -0.7056 -0.9937 3052644 PK04_100264 CN(C)CCCCCCNC(=O)[C@@H]1C[C@H]2N([C@@H]1c3cccc(OCCO)c3)C(=O)CNC2=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 N09 mock treatment 206140.0 -236000.0 -1.18 522350.0 107000.0 0.5 -0.4764 -0.3717 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 N10 mock treatment 229700.0 -212000.0 -1.06 264530.0 -151000.0 -0.71 -1.2507 -0.9808 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 N11 compound treatment 224800.0 -217000.0 -1.08 455440.0 40300.0 0.19 -0.633 -0.5748 3052880 PK04_100265 CN(C)CCCC[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3ccc(O)cc3)C(=O)NCCCCCN 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 N12 compound treatment 283040.0 -159000.0 -0.79 208350.0 -207000.0 -0.97 -1.2491 -0.9949 3176732 PK04_100266 CN(C)CCCC[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3ccc(O)cc3)C(=O)OCCOc4ccc(cc4)[C@@H]5N6[C@H]([C@H](C(=O)OCC=C)[C@@]57C(=O)Nc8ccc(I)cc87)C(=O)O[C@H]([C@H]6c9ccccc9)c%10ccccc%10 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 N13 mock treatment 428170.0 -13800.0 -0.07 260370.0 -155000.0 -0.73 -0.5636 -0.7707 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 N14 mock treatment 552040.0 110000.0 0.55 383300.0 -31800.0 -0.15 0.2828 0.4964 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 N15 compound treatment 396120.0 -45900.0 -0.23 497600.0 82500.0 0.39 0.1123 0.2492 3052703 PK04_100267 C[N+](C)(C)CCCC[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3cccc(OCCO)c3)C(=O)NCCCCCN 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 N16 compound treatment 505120.0 63100.0 0.32 397560.0 -17600.0 -0.08 0.1645 0.5047 3176120 PK04_100268 OCCOc1cccc(c1)[C@@H]2[C@@H](C[C@H]3N2C(=O)[C@H](Cc4ccccc4)NC3=O)C(=O)OCCOc5ccc(cc5)[C@@H]6N7[C@H]([C@H](C(=O)OCC=C)[C@@]68C(=O)Nc9ccc(I)cc98)C(=O)O[C@H]([C@H]7c%10ccccc%10)c%11ccccc%11 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 N17 compound treatment 515580.0 73600.0 0.37 425520.0 10400.0 0.05 0.2944 0.7942 3052843 PK04_100269 NCCCCCNC(=O)[C@@H]1C[C@H]2N([C@@H]1c3ccc(O)cc3)C(=O)CNC2=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 N18 compound treatment 592000.0 150000.0 0.75 388540.0 -26600.0 -0.13 0.4413 0.581 3176116 PK04_100270 OCCOc1cccc(c1)[C@@H]2[C@@H](C[C@H]3N2C(=O)[C@H](Cc4ccccc4)NC3=O)C(=O)NCCCCCNC(=O)CS 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 N19 compound treatment 365550.0 -76500.0 -0.38 533050.0 118000.0 0.55 0.1222 0.1815 3176319 PK04_100271 NCCCCCCNC(=O)[C@@H]1C[C@H]2N([C@@H]1c3cccc(OCCO)c3)C(=O)CNC2=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 N20 compound treatment 470910.0 28900.0 0.14 351270.0 -63900.0 -0.3 -0.1103 -0.331 3052797 PK04_100272 Oc1ccc(cc1)[C@@H]2[C@@H](C[C@H]3N2C(=O)[C@H](Cc4ccccc4)NC3=O)C(=O)NCCCCCNC(=O)CS 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 N21 compound treatment 455800.0 13800.0 0.07 497760.0 82600.0 0.39 0.3236 0.8197 3052581 PK04_100273 CC(C)C[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3cccc(OCCO)c3)C(=O)OCCOc4ccc(cc4)[C@@H]5N6[C@H]([C@H](C(=O)OCC=C)[C@@]57C(=O)Nc8ccccc87)C(=O)O[C@H]([C@H]6c9ccccc9)c%10ccccc%10 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 N22 compound treatment 365940.0 -76100.0 -0.38 485510.0 70400.0 0.33 -0.0345 -0.0685 3176118 PK04_100274 C[N+](C)(C)CCCCNC(=O)[C@@H]1C[C@H]2N([C@@H]1c3cccc(OCCO)c3)C(=O)[C@H](Cc4ccccc4)NC2=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 N23 compound treatment 497090.0 55100.0 0.28 601800.0 187000.0 0.88 0.8154 0.8862 3176207 PK04_100275 NCCCCCCNC(=O)[C@H]1C[C@@H]2N([C@H]1c3cccc(OCCO)c3)C(=O)CNC2=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 N24 compound treatment 465710.0 23700.0 0.12 360800.0 -54300.0 -0.26 -0.097 -0.3443 3176266 PK04_100276 C[N+](C)(C)CCCCNC(=O)[C@@H]1C[C@H]2N([C@@H]1c3cccc(OCCO)c3)C(=O)CNC2=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 O01 compound treatment 576280.0 134000.0 0.67 501660.0 86500.0 0.41 0.762 0.9714 3176687 PK04_100277 CN(C)CCCCNC(=O)[C@H]1C[C@@H]2N([C@H]1c3ccc(O)cc3)C(=O)[C@H](CCCCN(C)C)NC2=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 O02 compound treatment 503480.0 61500.0 0.31 561340.0 146000.0 0.69 0.7034 0.934 3176323 PK04_100278 C[N+](C)(C)CCCCCCNC(=O)[C@@H]1C[C@H]2N([C@@H]1c3cccc(OCCO)c3)C(=O)[C@H](CCCC[N+](C)(C)C)NC2=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 O03 compound treatment 594400.0 152000.0 0.76 513630.0 98500.0 0.46 0.8658 0.9717 3176438 PK04_100279 CN(C)CCCCNC(=O)[C@H]1C[C@@H]2N([C@H]1c3ccc(O)cc3)C(=O)[C@H](CCCCNC(=O)C)NC2=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 O04 compound treatment 242730.0 -199000.0 -1.0 220720.0 -194000.0 -0.91 -1.3504 -0.9991 3176117 PK04_100280 C[N+](C)(C)CCCCCCNC(=O)[C@@H]1C[C@H]2N([C@@H]1c3cccc(OCCO)c3)C(=O)[C@H](Cc4ccccc4)NC2=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 O05 compound treatment 203420.0 -239000.0 -1.19 280010.0 -135000.0 -0.64 -1.292 -0.9567 3176384 PK04_100281 NCCCCCNC(=O)[C@@H]1C[C@H]2N([C@@H]1c3cccc(OCCO)c3)C(=O)[C@H](CCCCN)NC2=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 O06 compound treatment 541600.0 99600.0 0.5 209130.0 -206000.0 -0.97 -0.3334 -0.3061 3052695 PK04_100282 C[N+](C)(C)CCCCCCNC(=O)[C@H]1C[C@@H]2N([C@H]1c3cccc(OCCO)c3)C(=O)[C@H](CCCC[N+](C)(C)C)NC2=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 O07 compound treatment 403680.0 -38300.0 -0.19 396000.0 -19100.0 -0.09 -0.199 -0.9408 3052929 PK04_100283 CN(C)CCCCNC(=O)[C@@H]1C[C@H]2N([C@@H]1c3ccc(O)cc3)C(=O)[C@H](CCCCN)NC2=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 O08 compound treatment 376570.0 -65400.0 -0.33 343420.0 -71700.0 -0.34 -0.4696 -0.9999 3052798 PK04_100284 C[N+](C)(C)CCCCCCNC(=O)[C@H]1C[C@@H]2N([C@H]1c3ccc(O)cc3)C(=O)[C@H](Cc4ccccc4)NC2=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 O09 compound treatment 435060.0 -6940.0 -0.03 505820.0 90700.0 0.43 0.2771 0.6475 3176509 PK04_100285 CC(C)C[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3ccc(O)cc3)C(=O)OCCOc4ccc(cc4)[C@H]5N6[C@@H]([C@@H](C(=O)OCC=C)[C@]57C(=O)Nc8ccc(I)cc87)C(=O)O[C@@H]([C@@H]6c9ccccc9)c%10ccccc%10 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 O10 compound treatment 423090.0 -18900.0 -0.09 586760.0 172000.0 0.81 0.5041 0.6201 3176681 PK04_100286 C[N+](C)(C)CCCCNC(=O)[C@H]1C[C@@H]2N([C@H]1c3ccc(O)cc3)C(=O)CNC2=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 O11 mock treatment 599360.0 157000.0 0.79 440800.0 25700.0 0.12 0.6411 0.8063 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 O12 mock treatment 509180.0 67200.0 0.34 402600.0 -12500.0 -0.06 0.1956 0.5741 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 O13 compound treatment 434240.0 -7760.0 -0.04 560480.0 145000.0 0.68 0.456 0.6659 3176682 PK04_100287 Oc1ccc(cc1)[C@H]2[C@H](C[C@@H]3N2C(=O)CNC3=O)C(=O)OCCOc4ccc(cc4)[C@@H]5N6[C@H]([C@H](C(=O)OCC=C)[C@@]57C(=O)Nc8ccc(I)cc87)C(=O)O[C@H]([C@H]6c9ccccc9)c%10ccccc%10 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 O14 compound treatment 440090.0 -1910.0 -0.01 450750.0 35600.0 0.17 0.1117 0.6658 3176320 PK04_100288 CN(C)CCCC[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3cccc(OCCO)c3)C(=O)NCCCCCCNC(=O)CS 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 O15 compound treatment 431110.0 -10900.0 -0.05 405120.0 -10000.0 -0.05 -0.0718 -0.9974 3176268 PK04_100289 OCCOc1cccc(c1)[C@H]2[C@H](C[C@@H]3N2C(=O)CNC3=O)C(=O)OCCOc4ccc(cc4)[C@@H]5N6[C@H]([C@H](C(=O)OCC=C)[C@@]57C(=O)Nc8ccc(I)cc87)C(=O)O[C@H]([C@H]6c9ccccc9)c%10ccccc%10 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 O16 compound treatment 526330.0 84300.0 0.42 410680.0 -4450.0 -0.02 0.283 0.6711 3176373 PK04_100290 C[N+](C)(C)CCCC[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3cccc(OCCO)c3)C(=O)NCCCCCCNC(=O)CS 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 O17 compound treatment 465880.0 23900.0 0.12 420010.0 4880.0 0.02 0.1006 0.828 3052700 PK04_100291 C[N+](C)(C)CCCC[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3cccc(OCCO)c3)C(=O)O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 O18 compound treatment 432330.0 -9670.0 -0.05 501560.0 86400.0 0.41 0.2533 0.6187 3176275 PK04_100292 CN(C)CCCC[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3cccc(OCCO)c3)C(=O)NCc4ccc(F)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 O19 compound treatment 525030.0 83000.0 0.41 569920.0 155000.0 0.73 0.8081 0.9644 3052887 PK04_100293 C[N+](C)(C)CCCC[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3ccc(O)cc3)C(=O)O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 O20 compound treatment 515470.0 73500.0 0.37 428000.0 12900.0 0.06 0.3023 0.8128 3176039 PK04_100294 CC(C)C[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3cccc(OCCO)c3)C(=O)NCc4ccc(F)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 O21 compound treatment 451680.0 9680.0 0.05 549440.0 134000.0 0.63 0.4809 0.759 3176637 PK04_100295 OC(=O)[C@H]1C[C@@H]2N([C@H]1c3ccc(O)cc3)C(=O)CNC2=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 O22 compound treatment 556260.0 114000.0 0.57 589220.0 174000.0 0.82 0.9825 0.9844 3176115 PK04_100296 OCCOc1cccc(c1)[C@H]2[C@H](C[C@@H]3N2C(=O)[C@H](Cc4ccccc4)NC3=O)C(=O)NCCCCCNC(=O)CS 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 O23 compound treatment 484530.0 42500.0 0.21 436480.0 21400.0 0.1 0.2212 0.9415 3052755 PK04_100297 CC(C)C[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3ccc(O)cc3)C(=O)O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 O24 compound treatment 444030.0 2030.0 0.01 548340.0 133000.0 0.63 0.4502 0.7185 3176443 PK04_100298 CC(=O)NCCCC[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3ccc(O)cc3)C(=O)NCCCCCNC(=O)CS 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 P01 compound treatment 301280.0 -141000.0 -0.7 293280.0 -122000.0 -0.57 -0.9022 -0.9949 3052698 PK04_100299 CN(C)CCCC[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3cccc(OCCO)c3)C(=O)OCCOc4ccc(cc4)[C@@H]5N6[C@H]([C@H](C(=O)OCC=C)[C@@]57C(=O)Nc8ccccc87)C(=O)O[C@H]([C@H]6c9ccccc9)c%10ccccc%10 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 P02 compound treatment 305080.0 -137000.0 -0.68 318800.0 -96300.0 -0.45 -0.8039 -0.98 3176634 PK04_100300 Oc1ccc(cc1)[C@@H]2[C@@H](C[C@H]3N2C(=O)[C@@H]4CCCN4C3=O)C(=O)OCCOc5ccc(cc5)[C@H]6N7[C@@H]([C@@H](C(=O)OCC=C)[C@]68C(=O)Nc9ccc(I)cc98)C(=O)O[C@@H]([C@@H]7c%10ccccc%10)c%11ccccc%11 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 P03 compound treatment 503230.0 61200.0 0.31 498560.0 83400.0 0.39 0.4937 0.9924 3174820 PK04_100301 CC(=O)NCCCC[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3cccc(OCCO)c3)C(=O)NCCCCCN 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 P04 compound treatment 383580.0 -58400.0 -0.29 163150.0 -252000.0 -1.19 -1.0444 -0.8556 3052597 PK04_100302 OCCOc1cccc(c1)[C@@H]2[C@@H](C[C@H]3N2C(=O)[C@@H]4CCCN4C3=O)C(=O)NCCCCCCNC(=O)CS 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 P05 compound treatment 146600.0 -295000.0 -1.48 231800.0 -183000.0 -0.86 -1.653 -0.9673 3176270 PK04_100303 OCCOc1cccc(c1)[C@@H]2[C@@H](C[C@H]3N2C(=O)CNC3=O)C(=O)OCCOc4ccc(cc4)[C@@H]5N6[C@H]([C@H](C(=O)OCC=C)[C@@]57C(=O)Nc8ccccc87)C(=O)O[C@H]([C@H]6c9ccccc9)c%10ccccc%10 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 P06 compound treatment 148740.0 -293000.0 -1.46 387960.0 -27200.0 -0.13 -1.1261 -0.7659 3176677 PK04_100304 Oc1ccc(cc1)[C@@H]2[C@@H](C[C@H]3N2C(=O)CNC3=O)C(=O)NCCCCCCNC(=O)CS 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 P07 compound treatment 450300.0 8300.0 0.04 418850.0 3720.0 0.02 0.0417 0.9264 3176122 PK04_100305 OCCOc1cccc(c1)[C@H]2[C@H](C[C@@H]3N2C(=O)[C@H](Cc4ccccc4)NC3=O)C(=O)OCCOc5ccc(cc5)[C@@H]6N7[C@H]([C@H](C(=O)OCC=C)[C@@]68C(=O)Nc9ccccc98)C(=O)O[C@H]([C@H]7c%10ccccc%10)c%11ccccc%11 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 P08 compound treatment 172520.0 -269000.0 -1.35 167520.0 -248000.0 -1.16 -1.7753 -0.9974 3052701 PK04_100306 CN(C)CCCCCCNC(=O)[C@@H]1C[C@H]2N([C@@H]1c3cccc(OCCO)c3)C(=O)[C@H](CCCC[N+](C)(C)C)NC2=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 P09 compound treatment 287560.0 -154000.0 -0.77 209130.0 -206000.0 -0.97 -1.2306 -0.9936 3175972 PK04_100307 CC(C)C[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3cccc(OCCO)c3)C(=O)NCCCCCN 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 P10 compound treatment 244130.0 -198000.0 -0.99 167940.0 -247000.0 -1.16 -1.521 -0.9967 3052830 PK04_100308 CN(C)CCCCCCNC(=O)[C@@H]1C[C@H]2N([C@@H]1c3ccc(O)cc3)C(=O)[C@@H]4CCCN4C2=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 P11 mock treatment 192890.0 -249000.0 -1.24 439410.0 24300.0 0.11 -0.799 -0.6395 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 P12 mock treatment 190960.0 -251000.0 -1.25 337350.0 -77800.0 -0.37 -1.1453 -0.8769 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 P13 compound treatment 413620.0 -28400.0 -0.14 230200.0 -185000.0 -0.87 -0.7153 -0.8116 3052541 PK04_100309 CC(C)C[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3cccc(OCCO)c3)C(=O)NCCCCCN 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 P14 compound treatment 383360.0 -58600.0 -0.29 436200.0 21100.0 0.1 -0.137 -0.4431 3052545 PK04_100310 CC(C)C[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3cccc(OCCO)c3)C(=O)OCCOc4ccc(cc4)[C@@H]5N6[C@H]([C@H](C(=O)OCC=C)[C@@]57C(=O)Nc8ccc(I)cc87)C(=O)O[C@H]([C@H]6c9ccccc9)c%10ccccc%10 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 P15 compound treatment 192930.0 -249000.0 -1.24 397170.0 -18000.0 -0.08 -0.9394 -0.7534 3176381 PK04_100311 CN(C)CCCCCCNC(=O)[C@@H]1C[C@H]2N([C@@H]1c3cccc(OCCO)c3)C(=O)[C@H](CCCCN)NC2=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 P16 compound treatment 400220.0 -41800.0 -0.21 263740.0 -151000.0 -0.71 -0.6511 -0.8774 3052789 PK04_100312 CC(C)C[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3ccc(O)cc3)C(=O)OCCOc4ccc(cc4)[C@@H]5N6[C@H]([C@H](C(=O)OCC=C)[C@@]57C(=O)Nc8ccc(I)cc87)C(=O)O[C@H]([C@H]6c9ccccc9)c%10ccccc%10 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 P17 compound treatment 455550.0 13500.0 0.07 408540.0 -6590.0 -0.03 0.0259 0.3484 3052890 PK04_100313 C[N+](C)(C)CCCC[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3ccc(O)cc3)C(=O)NCCCCCN 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 P18 compound treatment 300440.0 -142000.0 -0.71 434300.0 19200.0 0.09 -0.4362 -0.612 3176779 PK04_100314 C[N+](C)(C)CCCC[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3ccc(O)cc3)C(=O)NCCCCCNC(=O)CS 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 P19 compound treatment 297940.0 -144000.0 -0.72 328010.0 -87100.0 -0.41 -0.7985 -0.9644 3052876 PK04_100315 Oc1ccc(cc1)[C@@H]2[C@@H](C[C@H]3N2C(=O)CNC3=O)C(=O)OCCOc4ccc(cc4)[C@@H]5N6[C@H]([C@H](C(=O)OCC=C)[C@@]57C(=O)Nc8ccccc87)C(=O)O[C@H]([C@H]6c9ccccc9)c%10ccccc%10 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 P20 compound treatment 396200.0 -45800.0 -0.23 349990.0 -65100.0 -0.31 -0.3784 -0.9896 3176264 PK04_100316 OCCOc1cccc(c1)[C@@H]2[C@@H](C[C@H]3N2C(=O)CNC3=O)C(=O)NCCCCCNC(=O)CS 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 P21 compound treatment 405310.0 -36700.0 -0.18 272770.0 -142000.0 -0.67 -0.6031 -0.8687 3052692 PK04_100317 CN(C)CCCC[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3cccc(OCCO)c3)C(=O)NCCCCCN 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 P22 compound treatment 248320.0 -194000.0 -0.97 276850.0 -138000.0 -0.65 -1.1439 -0.9813 3176051 PK04_100318 CN(C)CCCCNC(=O)[C@@H]1C[C@H]2N([C@@H]1c3cccc(OCCO)c3)C(=O)[C@H](Cc4ccccc4)NC2=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 P23 compound treatment 425280.0 -16700.0 -0.08 554800.0 140000.0 0.66 0.4055 0.6123 3052754 PK04_100319 CC(=O)NCCCC[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3ccc(O)cc3)C(=O)OCCOc4ccc(cc4)[C@@H]5N6[C@H]([C@H](C(=O)OCC=C)[C@@]57C(=O)Nc8ccccc87)C(=O)O[C@H]([C@H]6c9ccccc9)c%10ccccc%10 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2100 P24 compound treatment 254940.0 -187000.0 -0.93 468930.0 53800.0 0.25 -0.4817 -0.4976 3176127 PK04_100320 CN(C)CCCCNC(=O)[C@@H]1C[C@H]2N([C@@H]1c3cccc(OCCO)c3)C(=O)[C@@H]4CCCN4C2=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 A01 compound treatment 117000.0 -265000.0 -1.32 450440.0 86800.0 0.41 -0.6472 -0.4673 3189007 PK04_101001 CC(C)N1CC=CC23O[C@@H]4C=CCOC(=O)[C@@H]4[C@H]3C(=O)N(CCCO)[C@@H]2C1=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 A02 compound treatment 124590.0 -257000.0 -1.29 437920.0 74300.0 0.35 -0.662 -0.4969 3069619 PK04_101002 OCCCN1[C@@H]2C(=O)N(Cc3ccccc3)CC=CC42O[C@@H]5C=CCCOC(=O)C5[C@H]4C1=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 A03 compound treatment 183680.0 -198000.0 -0.99 441570.0 77900.0 0.37 -0.4412 -0.4178 3189008 PK04_101003 CCCCCN1CC=CC23O[C@@H]4C=CCOC(=O)[C@@H]4[C@H]3C(=O)N(CCCO)[C@@H]2C1=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 A04 compound treatment 372320.0 -9660.0 -0.05 131720.0 -232000.0 -1.09 -0.8055 -0.7377 3189009 PK04_101004 CC(C)N1CC=CC23O[C@@H]4C=CCCOC(=O)C4[C@H]3C(=O)N(CCCO)[C@@H]2C1=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 A05 compound treatment 172840.0 -209000.0 -1.04 158490.0 -205000.0 -0.97 -1.421 -0.9992 3069620 PK04_101005 OCCCN1[C@@H]2C(=O)N(Cc3ccccc3)CC=CC42O[C@@H]5C=CCOC(=O)[C@@H]5[C@H]4C1=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 A06 compound treatment 194920.0 -187000.0 -0.93 418780.0 55100.0 0.26 -0.4773 -0.4923 3189010 PK04_101006 CCCCCN1CC=CC23O[C@@H]4C=CCCOC(=O)C4[C@H]3C(=O)N(CCCO)[C@@H]2C1=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 A07 compound treatment 168230.0 -214000.0 -1.07 186960.0 -177000.0 -0.83 -1.3426 -0.9923 3189011 PK04_101007 OCCCN1[C@@H]2C(=O)N(Cn3nnc4ccccc34)CC=CC52O[C@@H]6C=CCOC(=O)[C@@H]6[C@H]5C1=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 A08 compound treatment 499710.0 118000.0 0.59 190050.0 -174000.0 -0.82 -0.1616 -0.1606 3069621 PK04_101008 OCCCN1[C@@H]2C(=O)N(Cn3nnc4ccccc34)CC=CC52O[C@@H]6C=CCCOC(=O)C6[C@H]5C1=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 A09 compound treatment 167110.0 -215000.0 -1.07 180610.0 -183000.0 -0.86 -1.3676 -0.994 3189120 PK04_101009 CCCCN1CC=CC23O[C@@H]4C=CCOC(=O)[C@@H]4[C@H]3C(=O)N(CCCO)[C@@H]2C1=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 A10 compound treatment 151940.0 -230000.0 -1.15 153950.0 -210000.0 -0.99 -1.5099 -0.9971 3069622 PK04_101010 CCCCN1CC=CC23O[C@@H]4C=CCCOC(=O)C4[C@H]3C(=O)N(CCCO)[C@@H]2C1=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 A11 compound treatment 174010.0 -208000.0 -1.04 162980.0 -201000.0 -0.94 -1.4019 -0.9989 3189121 PK04_101011 CC(C)(C)N1CC=CC23O[C@@H]4C=CCOC(=O)[C@@H]4[C@H]3C(=O)N(CCCO)[C@@H]2C1=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 A12 compound treatment 395100.0 13100.0 0.07 152590.0 -211000.0 -0.99 -0.6557 -0.659 3069678 PK04_101012 CC(C)(C)N1CC=CC23O[C@@H]4C=CCCOC(=O)C4[C@H]3C(=O)N(CCCO)[C@@H]2C1=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 A13 mock treatment 235060.0 -147000.0 -0.73 177600.0 -186000.0 -0.88 -1.1377 -0.9962 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 A14 mock treatment 253160.0 -129000.0 -0.64 388530.0 24900.0 0.12 -0.3722 -0.5692 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 A15 compound treatment 225470.0 -157000.0 -0.78 266250.0 -97400.0 -0.46 -0.8767 -0.9676 3189122 PK04_101013 OCCCN1[C@@H]2C(=O)N(CCN3CCOCC3)CC=CC42O[C@@H]5C=CCOC(=O)[C@@H]5[C@H]4C1=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 A16 compound treatment 394400.0 12400.0 0.06 201010.0 -163000.0 -0.77 -0.4971 -0.6476 3069679 PK04_101014 OCCCN1[C@@H]2C(=O)N(CCN3CCOCC3)CC=CC42O[C@@H]5C=CCCOC(=O)C5[C@H]4C1=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 A17 compound treatment 373850.0 -8130.0 -0.04 426450.0 62800.0 0.3 0.1801 0.6042 3189123 PK04_101015 OCCCN1[C@@H]2C(=O)N(CC=CC32O[C@@H]4C=CCOC(=O)[C@@H]4[C@H]3C1=O)c5ccc6ccccc6c5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 A18 compound treatment 290200.0 -91800.0 -0.46 425710.0 62100.0 0.29 -0.1177 -0.2167 3189124 PK04_101016 OCCCN1[C@@H]2C(=O)N(CC=CC32O[C@@H]4C=CCCOC(=O)C4[C@H]3C1=O)c5ccc6ccccc6c5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 A19 compound treatment 195960.0 -186000.0 -0.93 417120.0 53500.0 0.25 -0.4791 -0.4978 3069680 PK04_101017 OCCCN1[C@@H]2C(=O)N(CC=CC32O[C@@H]4C=CCOC(=O)[C@@H]4[C@H]3C1=O)c5ccc(Cl)cc5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 A20 compound treatment 414580.0 32600.0 0.16 453650.0 90000.0 0.42 0.4145 0.9138 3189125 PK04_101018 OCCCN1[C@@H]2C(=O)N(CC=CC32O[C@@H]4C=CCCOC(=O)C4[C@H]3C1=O)c5ccc(Cl)cc5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 A21 compound treatment 331480.0 -50500.0 -0.25 267840.0 -95800.0 -0.45 -0.497 -0.9624 3069681 PK04_101019 CCN(CC)c1ccc(cc1)N2CC=CC34O[C@@H]5C=CCOC(=O)[C@@H]5[C@H]4C(=O)N(CCCO)[C@@H]3C2=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 A22 compound treatment 390790.0 8810.0 0.04 457480.0 93800.0 0.44 0.3432 0.7738 3189126 PK04_101020 CCN(CC)c1ccc(cc1)N2CC=CC34O[C@@H]5C=CCCOC(=O)C5[C@H]4C(=O)N(CCCO)[C@@H]3C2=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 A23 compound treatment 225530.0 -156000.0 -0.78 378900.0 15200.0 0.07 -0.5018 -0.6395 3189127 PK04_101021 OCCCCCN1[C@@H]2C(=O)N(Cc3ccccc3)CC=CC42O[C@@H]5C=CCOC(=O)[C@@H]5[C@H]4C1=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 A24 compound treatment 432330.0 50400.0 0.25 191200.0 -172000.0 -0.81 -0.3958 -0.466 3069682 PK04_101022 OCCN1[C@@H]2C(=O)N(Cc3ccccc3)CC=CC42O[C@@H]5C=CCCOC(=O)C5[C@H]4C1=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 B01 compound treatment 500480.0 119000.0 0.59 476080.0 112000.0 0.53 0.7924 0.9984 3189128 PK04_101023 CCCCCN1CC=CC23O[C@@H]4/C=C\CCCOC(=O)C4[C@H]3C(=O)N(CCO)[C@@H]2C1=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 B02 compound treatment 477760.0 95800.0 0.48 457940.0 94300.0 0.44 0.6519 0.9993 3189129 PK04_101024 CCCCN(CC=C)C(=O)C1N(C(=O)C2C(C3OC12C=C3)C(=O)O)c4c(Cl)cccc4CO 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 B03 compound treatment 333870.0 -48100.0 -0.24 497600.0 134000.0 0.63 0.2756 0.4087 3069683 PK04_101025 OCCN1[C@@H]2C(=O)N(Cn3nnc4ccccc34)CC=CC52O[C@@H]6/C=C\CCCOC(=O)C6[C@H]5C1=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 B04 compound treatment 305670.0 -76300.0 -0.38 465330.0 102000.0 0.48 0.0687 0.1123 3189130 PK04_101026 CC(C)(C)N(CC=C)C(=O)C1N(C(=O)C2C(C3OC12C=C3)C(=O)O)c4c(Cl)cccc4CO 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 B05 compound treatment 490140.0 108000.0 0.54 496050.0 132000.0 0.62 0.8223 0.9975 3069684 PK04_101027 CCCCN1CC=CC23O[C@@H]4/C=C\CCCOC(=O)C4[C@H]3C(=O)N(CCO)[C@@H]2C1=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 B06 compound treatment 423760.0 41800.0 0.21 474260.0 111000.0 0.52 0.5154 0.9195 3189131 PK04_101028 COc1ccc(cc1)N(CC=C)C(=O)C2N(C(=O)C3C(C4OC23C=C4)C(=O)O)c5c(Cl)cccc5CO 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 B07 compound treatment 436640.0 54700.0 0.27 505170.0 142000.0 0.67 0.6637 0.9225 3189132 PK04_101029 CC(C)(C)N1CC=CC23O[C@@H]4/C=C\CCCOC(=O)C4[C@H]3C(=O)N(CCO)[C@@H]2C1=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 B08 compound treatment 529950.0 148000.0 0.74 455930.0 92300.0 0.43 0.8295 0.9678 3069685 PK04_101030 OCc1cccc(Cl)c1N2C(C(=O)N(CC=C)Cc3ccccc3)C4(OC5C=C4)C(C5C(=O)O)C2=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 B09 compound treatment 498620.0 117000.0 0.58 493730.0 130000.0 0.61 0.8446 0.9997 3189133 PK04_101031 OCCN1[C@@H]2C(=O)N(CCN3CCOCC3)CC=CC42O[C@@H]5/C=C\CCCOC(=O)C5[C@H]4C1=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 B10 compound treatment 479530.0 97600.0 0.49 454530.0 90900.0 0.43 0.6468 0.9979 3189129 PK04_101032 CCCCN(CC=C)C(=O)C1N(C(=O)C2C(C3OC12C=C3)C(=O)O)c4c(Cl)cccc4CO 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 B11 compound treatment 459690.0 77700.0 0.39 453380.0 89700.0 0.42 0.5729 0.9991 3189134 PK04_101033 OCCN1[C@@H]2C(=O)N(CC=CC32O[C@@H]4/C=C\CCCOC(=O)C4[C@H]3C1=O)c5ccc6ccccc6c5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 B12 compound treatment 409090.0 27100.0 0.14 458990.0 95300.0 0.45 0.4128 0.8813 3069686 PK04_101034 CCCCCN(CC=C)C(=O)C1N(C(=O)C2C(C3OC12C=C3)C(=O)O)c4c(Cl)cccc4CO 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 B13 mock treatment 511250.0 129000.0 0.65 307550.0 -56100.0 -0.26 0.2699 0.387 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 B14 mock treatment 584010.0 202000.0 1.01 288670.0 -75000.0 -0.35 0.4641 0.4342 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 B15 compound treatment 537550.0 156000.0 0.78 440800.0 77100.0 0.36 0.806 0.9399 3189135 PK04_101035 C[C@]12C3[C@H](OC24C=CCN(C(=O)[C@H]4N(CCO)C1=O)c5ccc(Cl)cc5)/C=C\CCCOC3=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 B16 compound treatment 429080.0 47100.0 0.24 375360.0 11700.0 0.06 0.2053 0.8496 3069686 PK04_101036 CCCCCN(CC=C)C(=O)C1N(C(=O)C2C(C3OC12C=C3)C(=O)O)c4c(Cl)cccc4CO 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 B17 compound treatment 481720.0 99700.0 0.5 393990.0 30300.0 0.14 0.4531 0.8745 3189136 PK04_101037 CCN(CC)c1ccc(cc1)N2CC=CC34O[C@@H]5/C=C\CCCOC(=O)C5[C@H]4C(=O)N(CCO)[C@@H]3C2=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 B18 compound treatment 471060.0 89100.0 0.44 441540.0 77900.0 0.37 0.5736 0.9953 3069687 PK04_101038 COc1ccc(cc1)N(CC=C)C(=O)C2N(C(=O)C3C(C4OC23C=C4)C(=O)O)c5ccc(CCO)cc5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 B19 compound treatment 326640.0 -55300.0 -0.28 256700.0 -107000.0 -0.5 -0.5512 -0.9602 3189137 PK04_101039 CC1CC/C=C\[C@H]2OC34C=CCN(Cc5ccccc5)C(=O)[C@H]4N(CCO)C(=O)[C@@H]3C2C(=O)O1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 B20 compound treatment 522600.0 141000.0 0.7 528100.0 164000.0 0.77 1.0436 0.9988 3069688 PK04_101040 OCCc1ccc(cc1)N2C(C(=O)N(CC=C)Cc3ccccc3)C4(OC5C=C4)C(C5C(=O)O)C2=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 B21 compound treatment 478770.0 96800.0 0.48 487110.0 123000.0 0.58 0.7524 0.9958 3189138 PK04_101041 CC(C)N1CC=CC23O[C@@H]4/C=C\CCC(C)OC(=O)C4[C@H]3C(=O)N(CCO)[C@@H]2C1=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 B22 compound treatment 517210.0 135000.0 0.68 379950.0 16300.0 0.08 0.5318 0.7823 3189139 PK04_101042 CCCCN(CC=C)C(=O)C1N(C(=O)C2C(C3OC12C=C3)C(=O)O)c4ccc(CCO)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 B23 compound treatment 354720.0 -27300.0 -0.14 491840.0 128000.0 0.6 0.3301 0.534 3069689 PK04_101043 CCCCCN1CC=CC23O[C@@H]4/C=C\CCC(C)OC(=O)C4[C@H]3C(=O)N(CCO)[C@@H]2C1=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 B24 compound treatment 510430.0 128000.0 0.64 513280.0 150000.0 0.7 0.9513 0.9989 3189140 PK04_101044 CC(C)(C)N(CC=C)C(=O)C1N(C(=O)C2C(C3OC12C=C3)C(=O)O)c4ccc(CCO)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 C01 compound treatment 408840.0 26900.0 0.13 215230.0 -148000.0 -0.7 -0.3988 -0.561 3189247 PK04_101045 CC(C)N1CC=CC23O[C@@H]4C=CCOC(=O)[C@@H]4[C@H]3C(=O)N(CCCCCO)[C@@H]2C1=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 C02 compound treatment 400550.0 18600.0 0.09 365980.0 2330.0 0.01 0.0733 0.785 3069724 PK04_101046 CC(C)N1CC=CC23O[C@@H]4C=CCCOC(=O)C4[C@H]3C(=O)N(CCO)[C@@H]2C1=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 C03 compound treatment 205810.0 -176000.0 -0.88 179680.0 -184000.0 -0.87 -1.2341 -1.0 3189248 PK04_101047 CCCCCN1CC=CC23O[C@@H]4C=CCOC(=O)[C@@H]4[C@H]3C(=O)N(CCCCCO)[C@@H]2C1=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 C04 compound treatment 460000.0 78000.0 0.39 410080.0 46400.0 0.22 0.43 0.9625 3189249 PK04_101048 OCCN1[C@@H]2C(=O)N(Cn3nnc4ccccc34)CC=CC52O[C@@H]6C=CCCOC(=O)C6[C@H]5C1=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 C05 compound treatment 412410.0 30400.0 0.15 414940.0 51300.0 0.24 0.278 0.9752 3069725 PK04_101049 OCCCCCN1[C@@H]2C(=O)N(Cn3nnc4ccccc34)CC=CC52O[C@@H]6C=CCOC(=O)[C@@H]6[C@H]5C1=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 C06 compound treatment 220200.0 -162000.0 -0.81 224510.0 -139000.0 -0.65 -1.0341 -0.9945 3189250 PK04_101050 CCCCN1CC=CC23O[C@@H]4C=CCCOC(=O)C4[C@H]3C(=O)N(CCO)[C@@H]2C1=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 C07 compound treatment 450290.0 68300.0 0.34 229440.0 -134000.0 -0.63 -0.2051 -0.2859 3069726 PK04_101051 CCCCN1CC=CC23O[C@@H]4C=CCOC(=O)[C@@H]4[C@H]3C(=O)N(CCCCCO)[C@@H]2C1=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 C08 compound treatment 208740.0 -173000.0 -0.87 264000.0 -99700.0 -0.47 -0.9433 -0.9586 3189251 PK04_101052 CC(C)(C)N1CC=CC23O[C@@H]4C=CCCOC(=O)C4[C@H]3C(=O)N(CCO)[C@@H]2C1=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 C09 compound treatment 235280.0 -147000.0 -0.73 281920.0 -81700.0 -0.38 -0.7899 -0.9547 3189252 PK04_101053 CC(C)(C)N1CC=CC23O[C@@H]4C=CCOC(=O)[C@@H]4[C@H]3C(=O)N(CCCCCO)[C@@H]2C1=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 C10 compound treatment 182650.0 -199000.0 -1.0 154720.0 -209000.0 -0.98 -1.3989 -1.0 3069727 PK04_101054 OCCN1[C@@H]2C(=O)N(CCN3CCOCC3)CC=CC42O[C@@H]5C=CCCOC(=O)C5[C@H]4C1=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 C11 mock treatment 231770.0 -150000.0 -0.75 402080.0 38400.0 0.18 -0.4027 -0.5218 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 C12 mock treatment 236840.0 -145000.0 -0.72 404420.0 40800.0 0.19 -0.377 -0.5028 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 C13 compound treatment 301280.0 -80700.0 -0.4 200320.0 -163000.0 -0.77 -0.8282 -0.9547 3189253 PK04_101055 OCCCCCN1[C@@H]2C(=O)N(CCN3CCOCC3)CC=CC42O[C@@H]5C=CCOC(=O)[C@@H]5[C@H]4C1=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 C14 compound treatment 301240.0 -80700.0 -0.4 415050.0 51400.0 0.24 -0.1142 -0.2429 3069728 PK04_101056 OCCN1[C@@H]2C(=O)N(CC=CC32O[C@@H]4C=CCCOC(=O)C4[C@H]3C1=O)c5ccc6ccccc6c5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 C15 mock treatment 339490.0 -42500.0 -0.21 412500.0 48800.0 0.23 0.0124 0.0397 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 C16 mock treatment 265520.0 -116000.0 -0.58 424980.0 61300.0 0.29 -0.2073 -0.3193 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 C17 compound treatment 356420.0 -25600.0 -0.13 383490.0 19800.0 0.09 -0.0243 -0.1536 3189254 PK04_101057 OCCCCCN1[C@@H]2C(=O)N(CC=CC32O[C@@H]4C=CCOC(=O)[C@@H]4[C@H]3C1=O)c5ccc6ccccc6c5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 C18 compound treatment 316420.0 -65600.0 -0.33 219120.0 -145000.0 -0.68 -0.7123 -0.9439 3189255 PK04_101058 OCCN1[C@@H]2C(=O)N(CC=CC32O[C@@H]4C=CCCOC(=O)C4[C@H]3C1=O)c5ccc(Cl)cc5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 C19 compound treatment 223200.0 -159000.0 -0.79 317370.0 -46300.0 -0.22 -0.7147 -0.8691 3069729 PK04_101059 OCCCCCN1[C@@H]2C(=O)N(CC=CC32O[C@@H]4C=CCOC(=O)[C@@H]4[C@H]3C1=O)c5ccc(Cl)cc5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 C20 compound treatment 245090.0 -137000.0 -0.68 154890.0 -209000.0 -0.98 -1.1778 -0.9843 3189256 PK04_101060 CCN(CC)c1ccc(cc1)N2CC=CC34O[C@@H]5C=CCCOC(=O)C5[C@H]4C(=O)N(CCO)[C@@H]3C2=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 C21 compound treatment 380760.0 -1220.0 -0.01 196500.0 -167000.0 -0.79 -0.5603 -0.7126 3189257 PK04_101061 CCN(CC)c1ccc(cc1)N2CC=CC34O[C@@H]5C=CCOC(=O)[C@@H]5[C@H]4C(=O)N(CCCCCO)[C@@H]3C2=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 C22 compound treatment 432360.0 50400.0 0.25 183890.0 -180000.0 -0.85 -0.42 -0.476 3069730 PK04_101062 CC(CO)N1[C@@H]2C(=O)N(Cc3ccccc3)CC=CC42O[C@@H]5C=CCCOC(=O)C5[C@H]4C1=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 C23 compound treatment 387130.0 5150.0 0.03 388720.0 25100.0 0.12 0.1016 0.8416 3189258 PK04_101063 CC(C)C(CO)N1[C@@H]2C(=O)N(Cc3ccccc3)CC=CC42O[C@@H]5C=CCOC(=O)[C@@H]5[C@H]4C1=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 C24 compound treatment 230820.0 -151000.0 -0.75 375540.0 11900.0 0.06 -0.4943 -0.653 3069731 PK04_101064 CC(C)N1CC=CC23O[C@@H]4C=CCCOC(=O)C4[C@H]3C(=O)N(C(C)CO)[C@@H]2C1=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 D01 compound treatment 237140.0 -145000.0 -0.72 402430.0 38800.0 0.18 -0.3826 -0.5128 3189259 PK04_101065 CC1CC/C=C\[C@H]2OC34C=CCN(Cn5nnc6ccccc56)C(=O)[C@H]4N(CCO)C(=O)[C@@H]3C2C(=O)O1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 D02 compound treatment 458730.0 76800.0 0.38 462990.0 99300.0 0.47 0.6014 0.9952 3069687 PK04_101066 COc1ccc(cc1)N(CC=C)C(=O)C2N(C(=O)C3C(C4OC23C=C4)C(=O)O)c5ccc(CCO)cc5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 D03 compound treatment 472170.0 90200.0 0.45 484360.0 121000.0 0.57 0.72 0.9934 3189260 PK04_101067 CCCCN1CC=CC23O[C@@H]4/C=C\CCC(C)OC(=O)C4[C@H]3C(=O)N(CCO)[C@@H]2C1=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 D04 compound treatment 220840.0 -161000.0 -0.8 406160.0 42500.0 0.2 -0.4277 -0.5158 3069688 PK04_101068 OCCc1ccc(cc1)N2C(C(=O)N(CC=C)Cc3ccccc3)C4(OC5C=C4)C(C5C(=O)O)C2=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 D05 compound treatment 286560.0 -95400.0 -0.48 181220.0 -182000.0 -0.86 -0.9438 -0.9615 3069732 PK04_101069 CC1CC/C=C\[C@H]2OC34C=CCN(C(=O)[C@H]4N(CCO)C(=O)[C@@H]3C2C(=O)O1)C(C)(C)C 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 D06 compound treatment 429760.0 47800.0 0.24 450250.0 86600.0 0.41 0.4568 0.9676 3189139 PK04_101070 CCCCN(CC=C)C(=O)C1N(C(=O)C2C(C3OC12C=C3)C(=O)O)c4ccc(CCO)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 D07 compound treatment 356580.0 -25400.0 -0.13 352570.0 -11100.0 -0.05 -0.1266 -0.9228 3189261 PK04_101071 CC1CC/C=C\[C@H]2OC34C=CCN(CCN5CCOCC5)C(=O)[C@H]4N(CCO)C(=O)[C@@H]3C2C(=O)O1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 D08 compound treatment 519290.0 137000.0 0.69 249760.0 -114000.0 -0.54 0.1061 0.1219 3069733 PK04_101072 CCCCCN(CC=C)C(=O)C1N(C(=O)C2C(C3OC12C=C3)C(=O)O)c4ccc(CCO)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 D09 compound treatment 316240.0 -65700.0 -0.33 322030.0 -41600.0 -0.2 -0.3706 -0.9695 3189262 PK04_101073 CC1CC/C=C\[C@H]2OC34C=CCN(C(=O)[C@H]4N(CCO)C(=O)[C@@H]3C2C(=O)O1)c5ccc6ccccc6c5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 D10 compound treatment 417120.0 35100.0 0.18 425820.0 62200.0 0.29 0.3309 0.9702 3069733 PK04_101074 CCCCCN(CC=C)C(=O)C1N(C(=O)C2C(C3OC12C=C3)C(=O)O)c4ccc(CCO)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 D11 mock treatment 477340.0 95400.0 0.48 386950.0 23300.0 0.11 0.4143 0.8476 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 D12 mock treatment 460960.0 79000.0 0.39 307120.0 -56500.0 -0.27 0.0909 0.1911 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 D13 compound treatment 345440.0 -36500.0 -0.18 426000.0 62300.0 0.29 0.0783 0.2267 3189263 PK04_101075 CC1CC/C=C\[C@H]2OC34C=CCN(C(=O)[C@H]4N(CCO)C(=O)[C@]3(C)C2C(=O)O1)c5ccc(Cl)cc5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 D14 compound treatment 187780.0 -194000.0 -0.97 363270.0 -385.0 0.0 -0.6871 -0.7084 3069734 PK04_101076 CC(C)(C)N(CC=C)C(=O)C1N(CCOCCO)C(=O)C2C(C3OC12C=C3)C(=O)O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 D15 mock treatment 532740.0 151000.0 0.75 306030.0 -57600.0 -0.27 0.3408 0.4258 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 D16 mock treatment 406290.0 24300.0 0.12 497710.0 134000.0 0.63 0.5317 0.8281 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 D17 compound treatment 275260.0 -107000.0 -0.53 388890.0 25200.0 0.12 -0.293 -0.5365 3189264 PK04_101077 CCN(CC)c1ccc(cc1)N2CC=CC34O[C@@H]5/C=C\CCC(C)OC(=O)C5[C@H]4C(=O)N(CCO)[C@@H]3C2=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 D18 compound treatment 471930.0 90000.0 0.45 268320.0 -95300.0 -0.45 6.0E-4 9.0E-4 3069734 PK04_101078 CC(C)(C)N(CC=C)C(=O)C1N(CCOCCO)C(=O)C2C(C3OC12C=C3)C(=O)O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 D19 compound treatment 400550.0 18600.0 0.09 322190.0 -41500.0 -0.2 -0.0723 -0.3349 3069735 PK04_101079 CC1CC/C=C\[C@H]2OC34C=CCN(Cc5ccccc5)C(=O)[C@H]4N(CCCO)C(=O)[C@@H]3C2C(=O)O1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 D20 compound treatment 348590.0 -33400.0 -0.17 334620.0 -29000.0 -0.14 -0.2145 -0.9951 3189265 PK04_101080 COc1ccc(cc1)N(CC=C)C(=O)C2N(CCOCCO)C(=O)C3C(C4OC23C=C4)C(=O)O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 D21 compound treatment 379840.0 -2140.0 -0.01 387650.0 24000.0 0.11 0.0723 0.6373 3189266 PK04_101081 CC(C)N1CC=CC23O[C@@H]4/C=C\CCC(C)OC(=O)C4[C@H]3C(=O)N(CCCO)[C@@H]2C1=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 D22 compound treatment 488550.0 107000.0 0.53 479260.0 116000.0 0.54 0.7609 0.9999 3189265 PK04_101082 COc1ccc(cc1)N(CC=C)C(=O)C2N(CCOCCO)C(=O)C3C(C4OC23C=C4)C(=O)O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 D23 compound treatment 434880.0 52900.0 0.26 307260.0 -56400.0 -0.27 -7.0E-4 -0.002 3069736 PK04_101083 CCCCCN1CC=CC23O[C@@H]4/C=C\CCC(C)OC(=O)C4[C@H]3C(=O)N(CCCO)[C@@H]2C1=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 D24 compound treatment 410190.0 28200.0 0.14 205480.0 -158000.0 -0.74 -0.4265 -0.5632 3189267 PK04_101084 OCCOCCN1C(C(=O)N(CC=C)Cc2ccccc2)C3(OC4C=C3)C(C4C(=O)O)C1=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 E01 mock treatment 511680.0 130000.0 0.65 298690.0 -65000.0 -0.31 0.242 0.3379 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 E02 mock treatment 509350.0 127000.0 0.64 442420.0 78800.0 0.37 0.7118 0.9669 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 E03 compound treatment 354590.0 -27400.0 -0.14 208520.0 -155000.0 -0.73 -0.6127 -0.8253 3189373 PK04_101085 CC(C)C(CO)N1[C@@H]2C(=O)N(CC=CC32O[C@@H]4C=CCOC(=O)[C@@H]4[C@H]3C1=O)C(C)C 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 E04 compound treatment 255110.0 -127000.0 -0.63 464980.0 101000.0 0.48 -0.1111 -0.1401 3189374 PK04_101086 CCCCCN1CC=CC23O[C@@H]4C=CCCOC(=O)C4[C@H]3C(=O)N(C(C)CO)[C@@H]2C1=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 E05 compound treatment 441130.0 59200.0 0.3 458310.0 94700.0 0.45 0.5237 0.9802 3069761 PK04_101087 CCCCCN1CC=CC23O[C@@H]4C=CCOC(=O)[C@@H]4[C@H]3C(=O)N(C(CO)C(C)C)[C@@H]2C1=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 E06 compound treatment 495520.0 114000.0 0.57 234140.0 -130000.0 -0.61 -0.0298 -0.0358 3189375 PK04_101088 CC(CO)N1[C@@H]2C(=O)N(Cn3nnc4ccccc34)CC=CC52O[C@@H]6C=CCCOC(=O)C6[C@H]5C1=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 E07 compound treatment 219160.0 -163000.0 -0.81 489840.0 126000.0 0.59 -0.1553 -0.1543 3189376 PK04_101089 CC(C)C(CO)N1[C@@H]2C(=O)N(Cn3nnc4ccccc34)CC=CC52O[C@@H]6C=CCOC(=O)[C@@H]6[C@H]5C1=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 E08 compound treatment 471860.0 89900.0 0.45 390480.0 26800.0 0.13 0.4066 0.8721 3069762 PK04_101090 CCCCN1CC=CC23O[C@@H]4C=CCCOC(=O)C4[C@H]3C(=O)N(C(C)CO)[C@@H]2C1=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 E09 mock treatment 431290.0 49300.0 0.25 459290.0 95600.0 0.45 0.4922 0.9598 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 E10 mock treatment 450310.0 68300.0 0.34 457760.0 94100.0 0.44 0.5543 0.9917 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 E11 compound treatment 482510.0 101000.0 0.5 233230.0 -130000.0 -0.61 -0.0787 -0.0993 3189377 PK04_101091 CCCCN1CC=CC23O[C@@H]4C=CCOC(=O)[C@@H]4[C@H]3C(=O)N(C(CO)C(C)C)[C@@H]2C1=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 E12 compound treatment 198170.0 -184000.0 -0.92 320020.0 -43600.0 -0.21 -0.7943 -0.8443 3069763 PK04_101092 CC(CO)N1[C@@H]2C(=O)N(CC=CC32O[C@@H]4C=CCCOC(=O)C4[C@H]3C1=O)C(C)(C)C 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 E13 compound treatment 239880.0 -142000.0 -0.71 297550.0 -66100.0 -0.31 -0.7217 -0.9314 3189378 PK04_101093 CC(C)C(CO)N1[C@@H]2C(=O)N(CC=CC32O[C@@H]4C=CCOC(=O)[C@@H]4[C@H]3C1=O)C(C)(C)C 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 E14 compound treatment 367650.0 -14300.0 -0.07 358170.0 -5480.0 -0.03 -0.0688 -0.905 3189379 PK04_101094 CC(CO)N1[C@@H]2C(=O)N(CCN3CCOCC3)CC=CC42O[C@@H]5C=CCCOC(=O)C5[C@H]4C1=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 E15 compound treatment 415040.0 33100.0 0.17 235520.0 -128000.0 -0.6 -0.3094 -0.4951 3069764 PK04_101095 CC(C)C(CO)N1[C@@H]2C(=O)N(CCN3CCOCC3)CC=CC42O[C@@H]5C=CCOC(=O)[C@@H]5[C@H]4C1=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 E16 compound treatment 398100.0 16100.0 0.08 403520.0 39900.0 0.19 0.1895 0.9287 3189380 PK04_101096 CC(CO)N1[C@@H]2C(=O)N(CC=CC32O[C@@H]4C=CCCOC(=O)C4[C@H]3C1=O)c5ccc6ccccc6c5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 E17 mock treatment 437140.0 55200.0 0.28 469790.0 106000.0 0.5 0.5478 0.9607 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 E18 mock treatment 552730.0 171000.0 0.85 189770.0 -174000.0 -0.82 0.0247 0.0209 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 E19 compound treatment 338940.0 -43000.0 -0.21 439810.0 76200.0 0.36 0.1013 0.2425 3069765 PK04_101097 CC(C)C(CO)N1[C@@H]2C(=O)N(CC=CC32O[C@@H]4C=CCOC(=O)[C@@H]4[C@H]3C1=O)c5ccc6ccccc6c5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 E20 compound treatment 487140.0 105000.0 0.53 425550.0 61900.0 0.29 0.5773 0.9613 3189381 PK04_101098 CC(CO)N1[C@@H]2C(=O)N(CC=CC32O[C@@H]4C=CCCOC(=O)C4[C@H]3C1=O)c5ccc(Cl)cc5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 E21 compound treatment 461360.0 79400.0 0.4 441350.0 77700.0 0.37 0.5388 0.9992 3189382 PK04_101099 CC(C)C(CO)N1[C@@H]2C(=O)N(CC=CC32O[C@@H]4C=CCOC(=O)[C@@H]4[C@H]3C1=O)c5ccc(Cl)cc5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 E22 compound treatment 273960.0 -108000.0 -0.54 433090.0 69400.0 0.33 -0.1505 -0.2387 3069730 PK04_101100 CC(CO)N1[C@@H]2C(=O)N(Cc3ccccc3)CC=CC42O[C@@H]5C=CCCOC(=O)C5[C@H]4C1=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 E23 compound treatment 511200.0 129000.0 0.65 326730.0 -36900.0 -0.17 0.3336 0.4991 3069766 PK04_101101 CCN(CC)c1ccc(cc1)N2CC=CC34O[C@@H]5C=CCOC(=O)[C@@H]5[C@H]4C(=O)N(C(CO)C(C)C)[C@@H]3C2=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 E24 compound treatment 313560.0 -68400.0 -0.34 211950.0 -152000.0 -0.71 -0.7462 -0.9432 3069731 PK04_101102 CC(C)N1CC=CC23O[C@@H]4C=CCCOC(=O)C4[C@H]3C(=O)N(C(C)CO)[C@@H]2C1=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 F01 mock treatment 169680.0 -212000.0 -1.06 346790.0 -16900.0 -0.08 -0.8059 -0.7579 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 F02 mock treatment 236410.0 -146000.0 -0.73 502630.0 139000.0 0.65 -0.0519 -0.0531 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 F03 compound treatment 459200.0 77200.0 0.39 465700.0 102000.0 0.48 0.6121 0.9941 3189383 PK04_101103 CC1CC/C=C\[C@H]2OC34C=CCN(Cn5nnc6ccccc56)C(=O)[C@H]4N(CCCO)C(=O)[C@@H]3C2C(=O)O1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 F04 compound treatment 246280.0 -136000.0 -0.68 180400.0 -183000.0 -0.86 -1.0887 -0.9929 3189267 PK04_101104 OCCOCCN1C(C(=O)N(CC=C)Cc2ccccc2)C3(OC4C=C3)C(C4C(=O)O)C1=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 F05 compound treatment 171640.0 -210000.0 -1.05 486850.0 123000.0 0.58 -0.3331 -0.2776 3189384 PK04_101105 CCCCN1CC=CC23O[C@@H]4/C=C\CCC(C)OC(=O)C4[C@H]3C(=O)N(CCCO)[C@@H]2C1=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 F06 compound treatment 197950.0 -184000.0 -0.92 471280.0 108000.0 0.51 -0.292 -0.2782 3069767 PK04_101106 CCCCN(CC=C)C(=O)C1N(CCOCCO)C(=O)C2C(C3OC12C=C3)C(=O)O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 F07 compound treatment 413850.0 31900.0 0.16 453920.0 90300.0 0.42 0.4128 0.9103 3189385 PK04_101107 CC1CC/C=C\[C@H]2OC34C=CCN(C(=O)[C@H]4N(CCCO)C(=O)[C@@H]3C2C(=O)O1)C(C)(C)C 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 F08 compound treatment 512800.0 131000.0 0.65 220800.0 -143000.0 -0.67 -0.0131 -0.014 3069767 PK04_101108 CCCCN(CC=C)C(=O)C1N(CCOCCO)C(=O)C2C(C3OC12C=C3)C(=O)O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 F09 mock treatment 218560.0 -163000.0 -0.82 187520.0 -176000.0 -0.83 -1.163 -1.0 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 F10 mock treatment 497300.0 115000.0 0.58 420490.0 56800.0 0.27 0.5963 0.9391 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 F11 compound treatment 186990.0 -195000.0 -0.97 249450.0 -114000.0 -0.54 -1.0685 -0.9607 3069768 PK04_101109 CC1CC/C=C\[C@H]2OC34C=CCN(CCN5CCOCC5)C(=O)[C@H]4N(CCCO)C(=O)[C@@H]3C2C(=O)O1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 F12 compound treatment 241380.0 -141000.0 -0.7 518020.0 154000.0 0.73 0.0169 0.0167 3189386 PK04_101110 CCCCCN(CC=C)C(=O)C1N(CCOCCO)C(=O)C2C(C3OC12C=C3)C(=O)O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 F13 compound treatment 340830.0 -41100.0 -0.21 196960.0 -167000.0 -0.78 -0.6997 -0.8633 3189387 PK04_101111 CC1CC/C=C\[C@H]2OC34C=CCN(C(=O)[C@H]4N(CCCO)C(=O)[C@@H]3C2C(=O)O1)c5ccc6ccccc6c5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 F14 compound treatment 520480.0 139000.0 0.69 336640.0 -27000.0 -0.13 0.3993 0.5677 3189386 PK04_101112 CCCCCN(CC=C)C(=O)C1N(CCOCCO)C(=O)C2C(C3OC12C=C3)C(=O)O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 F15 compound treatment 382480.0 501.0 0.0 258200.0 -105000.0 -0.5 -0.349 -0.7035 3069769 PK04_101113 CC1CC/C=C\[C@H]2OC34C=CCN(C(=O)[C@H]4N(CCCO)C(=O)[C@]3(C)C2C(=O)O1)c5ccc(Cl)cc5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 F16 compound treatment 437190.0 55200.0 0.28 306290.0 -57400.0 -0.27 0.0042 0.0109 3189388 PK04_101114 CC(C)(C)N(CC=C)C(=O)C1N(C(=O)C2C(C3OC12C=C3)C(=O)O)C(C)(C)CO 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 F17 mock treatment 506480.0 125000.0 0.62 370310.0 6660.0 0.03 0.4618 0.7418 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 F18 mock treatment 512610.0 131000.0 0.65 265440.0 -98200.0 -0.46 0.1347 0.1685 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 F19 compound treatment 447680.0 65700.0 0.33 298810.0 -64800.0 -0.31 0.0164 0.0365 3189389 PK04_101115 CCN(CC)c1ccc(cc1)N2CC=CC34O[C@@H]5/C=C\CCC(C)OC(=O)C5[C@H]4C(=O)N(CCCO)[C@@H]3C2=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 F20 compound treatment 459380.0 77400.0 0.39 280850.0 -82800.0 -0.39 -0.0021 -0.0037 3189388 PK04_101116 CC(C)(C)N(CC=C)C(=O)C1N(C(=O)C2C(C3OC12C=C3)C(=O)O)C(C)(C)CO 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 F21 compound treatment 481480.0 99500.0 0.5 446400.0 82700.0 0.39 0.6266 0.9927 3069770 PK04_101117 OCCCN1[C@@H]2C(=O)N(Cc3ccccc3)CC=CC42O[C@@H]5/C=C\CCCOC(=O)C5[C@H]4C1=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 F22 compound treatment 519480.0 138000.0 0.69 411120.0 47500.0 0.22 0.6435 0.8911 3189390 PK04_101118 COc1ccc(cc1)N(CC=C)C(=O)C2N(C(=O)C3C(C4OC23C=C4)C(=O)O)C(C)(C)CO 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 F23 compound treatment 249120.0 -133000.0 -0.66 245120.0 -119000.0 -0.56 -0.8635 -0.9963 3189391 PK04_101119 CC(C)N1CC=CC23O[C@@H]4/C=C\CCCOC(=O)C4[C@H]3C(=O)N(CCCO)[C@@H]2C1=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 F24 compound treatment 206560.0 -175000.0 -0.88 208760.0 -155000.0 -0.73 -1.1347 -0.9958 3189390 PK04_101120 COc1ccc(cc1)N(CC=C)C(=O)C2N(C(=O)C3C(C4OC23C=C4)C(=O)O)C(C)(C)CO 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 G01 compound treatment 347080.0 -34900.0 -0.17 396980.0 33300.0 0.16 -0.0124 -0.0529 3189392 PK04_101121 CC(CO)N1[C@@H]2C(=O)N(Cc3ccccc3)CC=CC42O[C@@H]5C=CCOC(=O)[C@@H]5[C@H]4C1=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 G02 compound treatment 286250.0 -95700.0 -0.48 413310.0 49700.0 0.23 -0.1729 -0.325 3189374 PK04_101122 CCCCCN1CC=CC23O[C@@H]4C=CCCOC(=O)C4[C@H]3C(=O)N(C(C)CO)[C@@H]2C1=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 G03 mock treatment 286250.0 -95700.0 -0.48 336210.0 -27400.0 -0.13 -0.4294 -0.867 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 G04 mock treatment 200510.0 -181000.0 -0.91 169130.0 -195000.0 -0.91 -1.2879 -1.0 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 G05 compound treatment 531810.0 150000.0 0.75 481950.0 118000.0 0.56 0.9226 0.9894 3069794 PK04_101123 CC(C)N1CC=CC23O[C@@H]4C=CCOC(=O)[C@@H]4[C@H]3C(=O)N(C(C)CO)[C@@H]2C1=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 G06 compound treatment 196510.0 -185000.0 -0.93 195040.0 -169000.0 -0.79 -1.2158 -0.997 3189375 PK04_101124 CC(CO)N1[C@@H]2C(=O)N(Cn3nnc4ccccc34)CC=CC52O[C@@H]6C=CCCOC(=O)C6[C@H]5C1=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 G07 compound treatment 202080.0 -180000.0 -0.9 452990.0 89300.0 0.42 -0.3382 -0.341 3189393 PK04_101125 CCCCCN1CC=CC23O[C@@H]4C=CCOC(=O)[C@@H]4[C@H]3C(=O)N(C(C)CO)[C@@H]2C1=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 G08 compound treatment 508270.0 126000.0 0.63 475550.0 112000.0 0.53 0.8182 0.996 3069762 PK04_101126 CCCCN1CC=CC23O[C@@H]4C=CCCOC(=O)C4[C@H]3C(=O)N(C(C)CO)[C@@H]2C1=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 G09 compound treatment 514560.0 133000.0 0.66 469760.0 106000.0 0.5 0.8211 0.9903 3069795 PK04_101127 CC(CO)N1[C@@H]2C(=O)N(Cn3nnc4ccccc34)CC=CC52O[C@@H]6C=CCOC(=O)[C@@H]6[C@H]5C1=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 G10 compound treatment 180550.0 -201000.0 -1.01 481050.0 117000.0 0.55 -0.3209 -0.2796 3069763 PK04_101128 CC(CO)N1[C@@H]2C(=O)N(CC=CC32O[C@@H]4C=CCCOC(=O)C4[C@H]3C1=O)C(C)(C)C 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 G11 compound treatment 211170.0 -171000.0 -0.85 256480.0 -107000.0 -0.5 -0.9597 -0.9685 3189504 PK04_101129 CCCCN1CC=CC23O[C@@H]4C=CCOC(=O)[C@@H]4[C@H]3C(=O)N(C(C)CO)[C@@H]2C1=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 G12 compound treatment 481780.0 99800.0 0.5 180810.0 -183000.0 -0.86 -0.2557 -0.2572 3189379 PK04_101130 CC(CO)N1[C@@H]2C(=O)N(CCN3CCOCC3)CC=CC42O[C@@H]5C=CCCOC(=O)C5[C@H]4C1=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 G13 compound treatment 311160.0 -70800.0 -0.35 224130.0 -140000.0 -0.66 -0.7142 -0.9579 3069796 PK04_101131 CC(CO)N1[C@@H]2C(=O)N(CC=CC32O[C@@H]4C=CCOC(=O)[C@@H]4[C@H]3C1=O)C(C)(C)C 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 G14 compound treatment 359890.0 -22100.0 -0.11 356430.0 -7220.0 -0.03 -0.102 -0.8839 3189380 PK04_101132 CC(CO)N1[C@@H]2C(=O)N(CC=CC32O[C@@H]4C=CCCOC(=O)C4[C@H]3C1=O)c5ccc6ccccc6c5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 G15 compound treatment 223910.0 -158000.0 -0.79 315480.0 -48200.0 -0.23 -0.7185 -0.8747 3189505 PK04_101133 CC(CO)N1[C@@H]2C(=O)N(CCN3CCOCC3)CC=CC42O[C@@H]5C=CCOC(=O)[C@@H]5[C@H]4C1=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 G16 compound treatment 296120.0 -85900.0 -0.43 279040.0 -84600.0 -0.4 -0.5847 -0.9993 3189381 PK04_101134 CC(CO)N1[C@@H]2C(=O)N(CC=CC32O[C@@H]4C=CCCOC(=O)C4[C@H]3C1=O)c5ccc(Cl)cc5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 G17 compound treatment 457990.0 76000.0 0.38 357080.0 -6570.0 -0.03 0.2466 0.6474 3189506 PK04_101135 CC(CO)N1[C@@H]2C(=O)N(CC=CC32O[C@@H]4C=CCOC(=O)[C@@H]4[C@H]3C1=O)c5ccc6ccccc6c5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 G18 compound treatment 336990.0 -45000.0 -0.22 391250.0 27600.0 0.13 -0.0671 -0.2586 3069797 PK04_101136 CCN(CC)c1ccc(cc1)N2CC=CC34O[C@@H]5C=CCCOC(=O)C5[C@H]4C(=O)N(C(C)CO)[C@@H]3C2=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 G19 mock treatment 427840.0 45900.0 0.23 472720.0 109000.0 0.51 0.5247 0.934 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 G20 mock treatment 459620.0 77600.0 0.39 444260.0 80600.0 0.38 0.5423 0.9999 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 G21 compound treatment 475230.0 93300.0 0.47 454770.0 91100.0 0.43 0.6324 0.9991 3189507 PK04_101137 CC(CO)N1[C@@H]2C(=O)N(CC=CC32O[C@@H]4C=CCOC(=O)[C@@H]4[C@H]3C1=O)c5ccc(Cl)cc5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 G22 compound treatment 405820.0 23800.0 0.12 220680.0 -143000.0 -0.67 -0.3913 -0.573 3189508 PK04_101138 CC(C)C(CO)N1[C@@H]2C(=O)N(Cc3ccccc3)CC=CC42O[C@@H]5/C=C\CCCOC(=O)C5[C@H]4C1=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 G23 compound treatment 378530.0 -3450.0 -0.02 301040.0 -62600.0 -0.29 -0.2204 -0.7472 3069798 PK04_101139 CCN(CC)c1ccc(cc1)N2CC=CC34O[C@@H]5C=CCOC(=O)[C@@H]5[C@H]4C(=O)N(C(C)CO)[C@@H]3C2=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 G24 compound treatment 186730.0 -195000.0 -0.98 277800.0 -85900.0 -0.4 -0.9751 -0.9238 3189509 PK04_101140 CC(C)C(CO)N1[C@@H]2C(=O)N(CC=CC32O[C@@H]4/C=C\CCCOC(=O)C4[C@H]3C1=O)C(C)C 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 H01 compound treatment 161220.0 -221000.0 -1.1 198460.0 -165000.0 -0.78 -1.3291 -0.9853 3069799 PK04_101141 CCCCCN1CC=CC23O[C@@H]4/C=C\CCCOC(=O)C4[C@H]3C(=O)N(CCCO)[C@@H]2C1=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 H02 compound treatment 207470.0 -175000.0 -0.87 304480.0 -59200.0 -0.28 -0.8131 -0.8887 3189510 PK04_101142 CC(C)(CO)N1C(C(=O)N(CC=C)Cc2ccccc2)C3(OC4C=C3)C(C4C(=O)O)C1=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 H03 mock treatment 190250.0 -192000.0 -0.96 349380.0 -14300.0 -0.07 -0.7246 -0.7548 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 H04 mock treatment 520680.0 139000.0 0.69 517730.0 154000.0 0.72 1.0023 0.9997 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 H05 compound treatment 190840.0 -191000.0 -0.95 443360.0 79700.0 0.37 -0.4099 -0.3997 3189511 PK04_101143 OCCCN1[C@@H]2C(=O)N(Cn3nnc4ccccc34)CC=CC52O[C@@H]6/C=C\CCCOC(=O)C6[C@H]5C1=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 H06 compound treatment 247370.0 -135000.0 -0.67 548670.0 185000.0 0.87 0.14 0.1273 3069800 PK04_101144 CCCCN(CC=C)C(=O)C1N(C(=O)C2C(C3OC12C=C3)C(=O)O)C(C)(C)CO 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 H07 compound treatment 172880.0 -209000.0 -1.04 397400.0 33700.0 0.16 -0.6262 -0.5928 3189512 PK04_101145 CCCCN1CC=CC23O[C@@H]4/C=C\CCCOC(=O)C4[C@H]3C(=O)N(CCCO)[C@@H]2C1=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 H08 compound treatment 529530.0 148000.0 0.74 200060.0 -164000.0 -0.77 -0.023 -0.0216 3069800 PK04_101146 CCCCN(CC=C)C(=O)C1N(C(=O)C2C(C3OC12C=C3)C(=O)O)C(C)(C)CO 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 H09 compound treatment 503170.0 121000.0 0.61 243360.0 -120000.0 -0.57 0.0279 0.0337 3189513 PK04_101147 CC(C)(C)N1CC=CC23O[C@@H]4/C=C\CCCOC(=O)C4[C@H]3C(=O)N(CCCO)[C@@H]2C1=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 H10 compound treatment 427060.0 45100.0 0.23 287010.0 -76600.0 -0.36 -0.0957 -0.2252 3189510 PK04_101148 CC(C)(CO)N1C(C(=O)N(CC=C)Cc2ccccc2)C3(OC4C=C3)C(C4C(=O)O)C1=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 H11 compound treatment 298730.0 -83200.0 -0.42 513920.0 150000.0 0.71 0.2058 0.2509 3069801 PK04_101149 OCCCN1[C@@H]2C(=O)N(CCN3CCOCC3)CC=CC42O[C@@H]5/C=C\CCCOC(=O)C5[C@H]4C1=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 H12 compound treatment 311370.0 -70600.0 -0.35 195560.0 -168000.0 -0.79 -0.8084 -0.9338 3189514 PK04_101150 CCCCCN(CC=C)C(=O)C1N(C(=O)C2C(C3OC12C=C3)C(=O)O)C(C)(C)CO 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 H13 compound treatment 354030.0 -27900.0 -0.14 457140.0 93500.0 0.44 0.2122 0.46 3189515 PK04_101151 OCCCN1[C@@H]2C(=O)N(CC=CC32O[C@@H]4/C=C\CCCOC(=O)C4[C@H]3C1=O)c5ccc6ccccc6c5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 H14 compound treatment 533830.0 152000.0 0.76 224890.0 -139000.0 -0.65 0.0748 0.0747 3189514 PK04_101152 CCCCCN(CC=C)C(=O)C1N(C(=O)C2C(C3OC12C=C3)C(=O)O)C(C)(C)CO 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 H15 compound treatment 344480.0 -37500.0 -0.19 276850.0 -86800.0 -0.41 -0.4211 -0.9375 3069802 PK04_101153 C[C@]12C3[C@H](OC24C=CCN(C(=O)[C@H]4N(CCCO)C1=O)c5ccc(Cl)cc5)/C=C\CCCOC3=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 H16 compound treatment 333460.0 -48500.0 -0.24 418880.0 55200.0 0.26 0.0123 0.0347 3189516 PK04_101154 CC(C)(C)N(CC=C)C(=O)C1N(CCCCCCO)C(=O)C2C(C3OC12C=C3)C(=O)O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 H17 compound treatment 433530.0 51600.0 0.26 267360.0 -96300.0 -0.45 -0.1382 -0.2653 3189517 PK04_101155 CCN(CC)c1ccc(cc1)N2CC=CC34O[C@@H]5/C=C\CCCOC(=O)C5[C@H]4C(=O)N(CCCO)[C@@H]3C2=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 H18 compound treatment 371790.0 -10200.0 -0.05 380260.0 16600.0 0.08 0.0192 0.2065 3189516 PK04_101156 CC(C)(C)N(CC=C)C(=O)C1N(CCCCCCO)C(=O)C2C(C3OC12C=C3)C(=O)O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 H19 mock treatment 271570.0 -110000.0 -0.55 491760.0 128000.0 0.6 0.0362 0.0443 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 H20 mock treatment 590890.0 209000.0 1.04 252570.0 -111000.0 -0.52 0.3683 0.3156 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 H21 compound treatment 290360.0 -91600.0 -0.46 317790.0 -45900.0 -0.22 -0.4761 -0.9411 3069803 PK04_101157 OCCCCCN1[C@@H]2C(=O)N(Cc3ccccc3)CC=CC42O[C@@H]5/C=C\CCCOC(=O)C5[C@H]4C1=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 H22 compound treatment 308110.0 -73900.0 -0.37 232510.0 -131000.0 -0.62 -0.6971 -0.9698 3189518 PK04_101158 COc1ccc(cc1)N(CC=C)C(=O)C2N(CCCCCCO)C(=O)C3C(C4OC23C=C4)C(=O)O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 H23 compound treatment 444160.0 62200.0 0.31 451100.0 87400.0 0.41 0.5104 0.9904 3069804 PK04_101159 CC(C)N1CC=CC23O[C@@H]4/C=C\CCCOC(=O)C4[C@H]3C(=O)N(CCCCCO)[C@@H]2C1=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 H24 compound treatment 216650.0 -165000.0 -0.83 537540.0 174000.0 0.82 -0.0055 -0.0048 3189518 PK04_101160 COc1ccc(cc1)N(CC=C)C(=O)C2N(CCCCCCO)C(=O)C3C(C4OC23C=C4)C(=O)O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 I01 compound treatment 151000.0 -231000.0 -1.15 373660.0 10000.0 0.05 -0.7825 -0.6777 3189519 PK04_101161 OCCN1[C@@H]2C(=O)N(Cc3ccccc3)CC=CC42O[C@@H]5C=CCOC(=O)[C@@H]5[C@H]4C1=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 I02 compound treatment 295920.0 -86100.0 -0.43 354360.0 -9290.0 -0.04 -0.3348 -0.775 3189520 PK04_101162 CCCCCN1CC=CC23O[C@@H]4/C=C\CCCOC(=O)C4[C@H]3C(=O)N(C(CO)C(C)C)[C@@H]2C1=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 I03 compound treatment 480360.0 98400.0 0.49 383800.0 20100.0 0.09 0.4145 0.8282 3069839 PK04_101163 CC(C)N1CC=CC23O[C@@H]4C=CCOC(=O)[C@@H]4[C@H]3C(=O)N(CCO)[C@@H]2C1=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 I04 compound treatment 189330.0 -193000.0 -0.96 239360.0 -124000.0 -0.58 -1.0938 -0.9715 3189521 PK04_101164 CC(C)C(CO)N1[C@@H]2C(=O)N(Cn3nnc4ccccc34)CC=CC52O[C@@H]6/C=C\CCCOC(=O)C6[C@H]5C1=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 I05 mock treatment 483630.0 102000.0 0.51 205250.0 -158000.0 -0.75 -0.1679 -0.1862 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 I06 mock treatment 507450.0 125000.0 0.63 524860.0 161000.0 0.76 0.9793 0.9955 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 I07 compound treatment 377640.0 -4340.0 -0.02 493830.0 130000.0 0.61 0.4176 0.6817 3069840 PK04_101165 CCCCCN1CC=CC23O[C@@H]4C=CCOC(=O)[C@@H]4[C@H]3C(=O)N(CCO)[C@@H]2C1=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 I08 compound treatment 283470.0 -98500.0 -0.49 437130.0 73500.0 0.35 -0.1035 -0.1722 3189522 PK04_101166 CCCCN1CC=CC23O[C@@H]4/C=C\CCCOC(=O)C4[C@H]3C(=O)N(C(CO)C(C)C)[C@@H]2C1=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 I09 compound treatment 540240.0 158000.0 0.79 222590.0 -141000.0 -0.66 0.0897 0.087 3189523 PK04_101167 OCCN1[C@@H]2C(=O)N(Cn3nnc4ccccc34)CC=CC52O[C@@H]6C=CCOC(=O)[C@@H]6[C@H]5C1=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 I10 compound treatment 481160.0 99200.0 0.5 128250.0 -235000.0 -1.11 -0.4327 -0.3567 3069841 PK04_101168 CC(C)C(CO)N1[C@@H]2C(=O)N(CC=CC32O[C@@H]4/C=C\CCCOC(=O)C4[C@H]3C1=O)C(C)(C)C 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 I11 compound treatment 541700.0 160000.0 0.8 144510.0 -219000.0 -1.03 -0.1648 -0.1264 3189524 PK04_101169 CCCCN1CC=CC23O[C@@H]4C=CCOC(=O)[C@@H]4[C@H]3C(=O)N(CCO)[C@@H]2C1=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 I12 compound treatment 174990.0 -207000.0 -1.03 173930.0 -190000.0 -0.89 -1.362 -0.9973 3189640 PK04_101170 CC(C)C(CO)N1[C@@H]2C(=O)N(CCN3CCOCC3)CC=CC42O[C@@H]5/C=C\CCCOC(=O)C5[C@H]4C1=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 I13 compound treatment 564840.0 183000.0 0.91 377530.0 13900.0 0.07 0.692 0.7557 3069842 PK04_101171 CC(C)(C)N1CC=CC23O[C@@H]4C=CCOC(=O)[C@@H]4[C@H]3C(=O)N(CCO)[C@@H]2C1=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 I14 compound treatment 515040.0 133000.0 0.66 416530.0 52900.0 0.25 0.6458 0.9101 3189641 PK04_101172 CC(C)C(CO)N1[C@@H]2C(=O)N(CC=CC32O[C@@H]4/C=C\CCCOC(=O)C4[C@H]3C1=O)c5ccc6ccccc6c5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 I15 compound treatment 524400.0 142000.0 0.71 288800.0 -74900.0 -0.35 0.254 0.32 3069843 PK04_101173 OCCN1[C@@H]2C(=O)N(CCN3CCOCC3)CC=CC42O[C@@H]5C=CCOC(=O)[C@@H]5[C@H]4C1=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 I16 compound treatment 443360.0 61400.0 0.31 289310.0 -74300.0 -0.35 -0.0305 -0.0656 3189642 PK04_101174 CC(C)C(CO)N1[C@@H]2C(=O)N(CC=CC32O[C@@H]4/C=C\CCCOC(=O)C4[C@@]3(C)C1=O)c5ccc(Cl)cc5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 I17 compound treatment 450280.0 68300.0 0.34 205670.0 -158000.0 -0.74 -0.2842 -0.3476 3069844 PK04_101175 OCCN1[C@@H]2C(=O)N(CC=CC32O[C@@H]4C=CCOC(=O)[C@@H]4[C@H]3C1=O)c5ccc6ccccc6c5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 I18 compound treatment 368380.0 -13600.0 -0.07 322430.0 -41200.0 -0.19 -0.1851 -0.9011 3189643 PK04_101176 CCN(CC)c1ccc(cc1)N2CC=CC34O[C@@H]5/C=C\CCCOC(=O)C5[C@H]4C(=O)N(C(CO)C(C)C)[C@@H]3C2=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 I19 compound treatment 493330.0 111000.0 0.56 483360.0 120000.0 0.56 0.7914 1.0 3069845 PK04_101177 OCCN1[C@@H]2C(=O)N(CC=CC32O[C@@H]4C=CCOC(=O)[C@@H]4[C@H]3C1=O)c5ccc(Cl)cc5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 I20 compound treatment 510560.0 129000.0 0.64 247210.0 -116000.0 -0.55 0.0668 0.0792 3189644 PK04_101178 CC(C)C(CO)N1[C@@H]2C(=O)N(Cc3ccccc3)CC=CC42O[C@@H]5/C=C\CCC(C)OC(=O)C5[C@H]4C1=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 I21 mock treatment 361190.0 -20800.0 -0.1 254210.0 -109000.0 -0.51 -0.4374 -0.833 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 I22 mock treatment 495200.0 113000.0 0.57 503320.0 140000.0 0.66 0.8644 0.9972 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 I23 compound treatment 469640.0 87700.0 0.44 391640.0 28000.0 0.13 0.4027 0.8808 3189645 PK04_101179 CCN(CC)c1ccc(cc1)N2CC=CC34O[C@@H]5C=CCOC(=O)[C@@H]5[C@H]4C(=O)N(CCO)[C@@H]3C2=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 I24 compound treatment 208640.0 -173000.0 -0.87 208350.0 -155000.0 -0.73 -1.1287 -0.9964 3069846 PK04_101180 CC(C)C(CO)N1[C@@H]2C(=O)N(CC=CC32O[C@@H]4/C=C\CCC(C)OC(=O)C4[C@H]3C1=O)C(C)C 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 J01 compound treatment 463270.0 81300.0 0.41 154640.0 -209000.0 -0.98 -0.4081 -0.3837 3189646 PK04_101181 CCCCCN1CC=CC23O[C@@H]4/C=C\CCCOC(=O)C4[C@H]3C(=O)N(CCCCCO)[C@@H]2C1=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 J02 compound treatment 294090.0 -87900.0 -0.44 484960.0 121000.0 0.57 0.0931 0.1293 3189647 PK04_101182 OCCCCCCN1C(C(=O)N(CC=C)Cc2ccccc2)C3(OC4C=C3)C(C4C(=O)O)C1=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 J03 compound treatment 218000.0 -164000.0 -0.82 124450.0 -239000.0 -1.13 -1.3747 -0.9878 3069847 PK04_101183 OCCCCCN1[C@@H]2C(=O)N(Cn3nnc4ccccc34)CC=CC52O[C@@H]6/C=C\CCCOC(=O)C6[C@H]5C1=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 J04 compound treatment 186920.0 -195000.0 -0.97 129560.0 -234000.0 -1.1 -1.4675 -0.9981 3189647 PK04_101184 OCCCCCCN1C(C(=O)N(CC=C)Cc2ccccc2)C3(OC4C=C3)C(C4C(=O)O)C1=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 J05 mock treatment 214740.0 -167000.0 -0.84 233210.0 -130000.0 -0.61 -1.0245 -0.9885 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 J06 mock treatment 521880.0 140000.0 0.7 311580.0 -52100.0 -0.24 0.3209 0.4334 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 J07 compound treatment 459580.0 77600.0 0.39 154530.0 -209000.0 -0.98 -0.4215 -0.3987 3189648 PK04_101185 CCCCN1CC=CC23O[C@@H]4/C=C\CCCOC(=O)C4[C@H]3C(=O)N(CCCCCO)[C@@H]2C1=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 J08 compound treatment 544010.0 162000.0 0.81 204240.0 -159000.0 -0.75 0.042 0.0381 3189649 PK04_101186 CCCCN(CC=C)C(=O)C1N(CCCCCCO)C(=O)C2C(C3OC12C=C3)C(=O)O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 J09 compound treatment 182080.0 -200000.0 -1.0 420510.0 56900.0 0.27 -0.5169 -0.5001 3069848 PK04_101187 CC(C)(C)N1CC=CC23O[C@@H]4/C=C\CCCOC(=O)C4[C@H]3C(=O)N(CCCCCO)[C@@H]2C1=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 J10 compound treatment 241550.0 -140000.0 -0.7 354530.0 -9120.0 -0.04 -0.5263 -0.749 3189649 PK04_101188 CCCCN(CC=C)C(=O)C1N(CCCCCCO)C(=O)C2C(C3OC12C=C3)C(=O)O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 J11 compound treatment 426930.0 45000.0 0.22 268600.0 -95100.0 -0.45 -0.1574 -0.3146 3189650 PK04_101189 OCCCCCN1[C@@H]2C(=O)N(CCN3CCOCC3)CC=CC42O[C@@H]5/C=C\CCCOC(=O)C5[C@H]4C1=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 J12 compound treatment 387620.0 5640.0 0.03 442720.0 79100.0 0.37 0.2829 0.7585 3189651 PK04_101190 CCCCCN(CC=C)C(=O)C1N(CCCCCCO)C(=O)C2C(C3OC12C=C3)C(=O)O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 J13 compound treatment 404960.0 23000.0 0.11 263550.0 -100000.0 -0.47 -0.2518 -0.5195 3069849 PK04_101191 OCCCCCN1[C@@H]2C(=O)N(CC=CC32O[C@@H]4/C=C\CCCOC(=O)C4[C@H]3C1=O)c5ccc6ccccc6c5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 J14 compound treatment 470180.0 88200.0 0.44 262600.0 -101000.0 -0.48 -0.0246 -0.038 3189651 PK04_101192 CCCCCN(CC=C)C(=O)C1N(CCCCCCO)C(=O)C2C(C3OC12C=C3)C(=O)O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 J15 compound treatment 363970.0 -18000.0 -0.09 337040.0 -26600.0 -0.13 -0.1521 -0.9868 3189652 PK04_101193 C[C@]12C3[C@H](OC24C=CCN(C(=O)[C@H]4N(CCCCCO)C1=O)c5ccc(Cl)cc5)/C=C\CCCOC3=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 J16 compound treatment 350890.0 -31100.0 -0.16 297500.0 -66200.0 -0.31 -0.3298 -0.9484 3069850 PK04_101194 CC(C)(C)N(CC=C)C(=O)C(N(C(=O)/C=C\C(=O)O)c1c(Cl)cccc1CO)c2cccs2 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 J17 compound treatment 385030.0 3050.0 0.02 267580.0 -96100.0 -0.45 -0.3088 -0.6829 3189653 PK04_101195 CCN(CC)c1ccc(cc1)N2CC=CC34O[C@@H]5/C=C\CCCOC(=O)C5[C@H]4C(=O)N(CCCCCO)[C@@H]3C2=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 J18 compound treatment 343800.0 -38200.0 -0.19 349920.0 -13700.0 -0.06 -0.1805 -0.8966 3069850 PK04_101196 CC(C)(C)N(CC=C)C(=O)C(N(C(=O)/C=C\C(=O)O)c1c(Cl)cccc1CO)c2cccs2 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 J19 compound treatment 354000.0 -28000.0 -0.14 306090.0 -57600.0 -0.27 -0.2903 -0.9527 3189654 PK04_101197 CC1CC/C=C\[C@H]2OC34C=CCN(Cc5ccccc5)C(=O)[C@H]4N(CCCCCO)C(=O)[C@@H]3C2C(=O)O1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 J20 compound treatment 275170.0 -107000.0 -0.53 361840.0 -1810.0 -0.01 -0.3832 -0.7183 3069851 PK04_101198 COc1ccc(cc1)N(CC=C)C(=O)C(N(C(=O)/C=C\C(=O)O)c2c(Cl)cccc2CO)c3cccs3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 J21 mock treatment 510170.0 128000.0 0.64 476010.0 112000.0 0.53 0.8264 0.9955 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 J22 mock treatment 454680.0 72700.0 0.36 534260.0 171000.0 0.8 0.8242 0.9357 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 J23 compound treatment 199960.0 -182000.0 -0.91 391380.0 27700.0 0.13 -0.5506 -0.5995 3189655 PK04_101199 CC(C)N1CC=CC23O[C@@H]4/C=C\CCC(C)OC(=O)C4[C@H]3C(=O)N(CCCCCO)[C@@H]2C1=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 J24 compound treatment 506570.0 125000.0 0.62 231960.0 -132000.0 -0.62 0.002 0.0023 3069851 PK04_101200 COc1ccc(cc1)N(CC=C)C(=O)C(N(C(=O)/C=C\C(=O)O)c2c(Cl)cccc2CO)c3cccs3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 K01 compound treatment 531860.0 150000.0 0.75 222120.0 -142000.0 -0.67 0.0586 0.0585 3189656 PK04_101201 OCCCCCCN1[C@@H]2C(=O)N(Cc3ccccc3)CC=CC42O[C@@H]5C=CCOC(=O)[C@@H]5[C@H]4C1=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 K02 compound treatment 178780.0 -203000.0 -1.01 485680.0 122000.0 0.57 -0.3118 -0.2674 3189657 PK04_101202 CCCCCN1CC=CC23O[C@@H]4/C=C\CCC(C)OC(=O)C4[C@H]3C(=O)N(C(CO)C(C)C)[C@@H]2C1=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 K03 compound treatment 407630.0 25700.0 0.13 178750.0 -185000.0 -0.87 -0.5244 -0.5965 3069890 PK04_101203 CC(C)N1CC=CC23O[C@@H]4C=CCOC(=O)[C@@H]4[C@H]3C(=O)N(CCCCCCO)[C@@H]2C1=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 K04 compound treatment 105050.0 -277000.0 -1.38 463650.0 100000.0 0.47 -0.6454 -0.4418 3189658 PK04_101204 CC(C)C(CO)N1[C@@H]2C(=O)N(Cn3nnc4ccccc34)CC=CC52O[C@@H]6/C=C\CCC(C)OC(=O)C6[C@H]5C1=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 K05 compound treatment 205030.0 -177000.0 -0.88 149120.0 -215000.0 -1.01 -1.3385 -0.9978 3069891 PK04_101205 CCCCCN1CC=CC23O[C@@H]4C=CCOC(=O)[C@@H]4[C@H]3C(=O)N(CCCCCCO)[C@@H]2C1=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 K06 compound treatment 182520.0 -199000.0 -1.0 165120.0 -199000.0 -0.93 -1.3647 -0.9995 3189659 PK04_101206 CCCCN1CC=CC23O[C@@H]4/C=C\CCC(C)OC(=O)C4[C@H]3C(=O)N(C(CO)C(C)C)[C@@H]2C1=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 K07 mock treatment 209570.0 -172000.0 -0.86 286640.0 -77000.0 -0.36 -0.865 -0.926 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 K08 mock treatment 171010.0 -211000.0 -1.05 534740.0 171000.0 0.8 -0.176 -0.1328 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 K09 compound treatment 502210.0 120000.0 0.6 209540.0 -154000.0 -0.72 -0.088 -0.0935 3187684 PK04_101207 OCCCCCCN1[C@@H]2C(=O)N(Cn3nnc4ccccc34)CC=CC52O[C@@H]6C=CCOC(=O)[C@@H]6[C@H]5C1=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 K10 compound treatment 235080.0 -147000.0 -0.73 169990.0 -194000.0 -0.91 -1.1629 -0.9942 3069892 PK04_101208 CC(C)C(CO)N1[C@@H]2C(=O)N(CC=CC32O[C@@H]4/C=C\CCC(C)OC(=O)C4[C@H]3C1=O)C(C)(C)C 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 K11 compound treatment 222420.0 -160000.0 -0.8 167320.0 -196000.0 -0.92 -1.2165 -0.9973 3187685 PK04_101209 CCCCN1CC=CC23O[C@@H]4C=CCOC(=O)[C@@H]4[C@H]3C(=O)N(CCCCCCO)[C@@H]2C1=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 K12 compound treatment 307650.0 -74300.0 -0.37 194650.0 -169000.0 -0.79 -0.8246 -0.9399 3187686 PK04_101210 CC(C)C(CO)N1[C@@H]2C(=O)N(CCN3CCOCC3)CC=CC42O[C@@H]5/C=C\CCC(C)OC(=O)C5[C@H]4C1=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 K13 compound treatment 420640.0 38700.0 0.19 372180.0 8530.0 0.04 0.1649 0.8361 3069893 PK04_101211 CC(C)(C)N1CC=CC23O[C@@H]4C=CCOC(=O)[C@@H]4[C@H]3C(=O)N(CCCCCCO)[C@@H]2C1=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 K14 compound treatment 399880.0 17900.0 0.09 284430.0 -79200.0 -0.37 -0.2003 -0.5226 3187687 PK04_101212 CC(C)C(CO)N1[C@@H]2C(=O)N(CC=CC32O[C@@H]4/C=C\CCC(C)OC(=O)C4[C@H]3C1=O)c5ccc6ccccc6c5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 K15 mock treatment 529960.0 148000.0 0.74 247870.0 -116000.0 -0.54 0.1375 0.1498 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 K16 mock treatment 412330.0 30400.0 0.15 395870.0 32200.0 0.15 0.2143 1.0 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 K17 compound treatment 501230.0 119000.0 0.6 327850.0 -35800.0 -0.17 0.3021 0.488 3069894 PK04_101213 OCCCCCCN1[C@@H]2C(=O)N(CCN3CCOCC3)CC=CC42O[C@@H]5C=CCOC(=O)[C@@H]5[C@H]4C1=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 K18 compound treatment 367450.0 -14500.0 -0.07 480930.0 117000.0 0.55 0.3387 0.6088 3187688 PK04_101214 CC(C)C(CO)N1[C@@H]2C(=O)N(CC=CC32O[C@@H]4/C=C\CCC(C)OC(=O)C4[C@@]3(C)C1=O)c5ccc(Cl)cc5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 K19 compound treatment 550800.0 169000.0 0.84 525880.0 162000.0 0.76 1.1358 0.9988 3069895 PK04_101215 OCCCCCCN1[C@@H]2C(=O)N(CC=CC32O[C@@H]4C=CCOC(=O)[C@@H]4[C@H]3C1=O)c5ccc6ccccc6c5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 K20 compound treatment 493960.0 112000.0 0.56 405170.0 41500.0 0.2 0.5336 0.9007 3187689 PK04_101216 CCN(CC)c1ccc(cc1)N2CC=CC34O[C@@H]5/C=C\CCC(C)OC(=O)C5[C@H]4C(=O)N(C(CO)C(C)C)[C@@H]3C2=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 K21 compound treatment 442010.0 60000.0 0.3 322510.0 -41100.0 -0.19 0.0752 0.2106 3187690 PK04_101217 OCCCCCCN1[C@@H]2C(=O)N(CC=CC32O[C@@H]4C=CCOC(=O)[C@@H]4[C@H]3C1=O)c5ccc(Cl)cc5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 K22 compound treatment 466500.0 84500.0 0.42 257640.0 -106000.0 -0.5 -0.0541 -0.0828 3069896 PK04_101218 CC(CO)N1[C@@H]2C(=O)N(Cc3ccccc3)CC=CC42O[C@@H]5/C=C\CCC(C)OC(=O)C5[C@H]4C1=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 K23 mock treatment 472440.0 90500.0 0.45 483120.0 119000.0 0.56 0.7168 0.9942 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 K24 mock treatment 532800.0 151000.0 0.75 424610.0 61000.0 0.29 0.7354 0.9124 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 L01 compound treatment 438400.0 56400.0 0.28 387840.0 24200.0 0.11 0.2797 0.9204 3187691 PK04_101219 CCCCCN1CC=CC23O[C@@H]4/C=C\CCC(C)OC(=O)C4[C@H]3C(=O)N(CCCCCO)[C@@H]2C1=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 L02 compound treatment 168160.0 -214000.0 -1.07 176830.0 -187000.0 -0.88 -1.3765 -0.9953 3187692 PK04_101220 OCc1cccc(Cl)c1N(C(C(=O)N(CC=C)Cc2ccccc2)c3cccs3)C(=O)/C=C\C(=O)O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 L03 compound treatment 467770.0 85800.0 0.43 248770.0 -115000.0 -0.54 -0.0791 -0.1147 3069897 PK04_101221 CC1CC/C=C\[C@H]2OC34C=CCN(Cn5nnc6ccccc56)C(=O)[C@H]4N(CCCCCO)C(=O)[C@@H]3C2C(=O)O1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 L04 compound treatment 416650.0 34700.0 0.17 246770.0 -117000.0 -0.55 -0.2663 -0.462 3187693 PK04_101222 CCCCN(CC=C)C(=O)C(N(C(=O)/C=C\C(=O)O)c1c(Cl)cccc1CO)c2cccs2 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 L05 compound treatment 171000.0 -211000.0 -1.05 412050.0 48400.0 0.23 -0.5841 -0.5419 3187694 PK04_101223 CCCCN1CC=CC23O[C@@H]4/C=C\CCC(C)OC(=O)C4[C@H]3C(=O)N(CCCCCO)[C@@H]2C1=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 L06 compound treatment 244050.0 -138000.0 -0.69 181630.0 -182000.0 -0.86 -1.0925 -0.9942 3187693 PK04_101224 CCCCN(CC=C)C(=O)C(N(C(=O)/C=C\C(=O)O)c1c(Cl)cccc1CO)c2cccs2 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 L07 mock treatment 249010.0 -133000.0 -0.66 480970.0 117000.0 0.55 -0.0794 -0.092 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 L08 mock treatment 158400.0 -224000.0 -1.12 504090.0 140000.0 0.66 -0.3225 -0.2486 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 L09 compound treatment 278720.0 -103000.0 -0.52 380960.0 17300.0 0.08 -0.3071 -0.5882 3069898 PK04_101225 CC1CC/C=C\[C@H]2OC34C=CCN(C(=O)[C@H]4N(CCCCCO)C(=O)[C@@H]3C2C(=O)O1)C(C)(C)C 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 L10 compound treatment 172320.0 -210000.0 -1.05 483790.0 120000.0 0.57 -0.3409 -0.2865 3187692 PK04_101226 OCc1cccc(Cl)c1N(C(C(=O)N(CC=C)Cc2ccccc2)c3cccs3)C(=O)/C=C\C(=O)O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 L11 compound treatment 172350.0 -210000.0 -1.05 318250.0 -45400.0 -0.21 -0.8914 -0.8342 3187695 PK04_101227 CC1CC/C=C\[C@H]2OC34C=CCN(CCN5CCOCC5)C(=O)[C@H]4N(CCCCCO)C(=O)[C@@H]3C2C(=O)O1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 L12 compound treatment 411800.0 29800.0 0.15 268660.0 -95000.0 -0.45 -0.2106 -0.4472 3187696 PK04_101228 CCCCCN(CC=C)C(=O)C(N(C(=O)/C=C\C(=O)O)c1c(Cl)cccc1CO)c2cccs2 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 L13 compound treatment 495000.0 113000.0 0.56 202630.0 -161000.0 -0.76 -0.1364 -0.1444 3069899 PK04_101229 CC1CC/C=C\[C@H]2OC34C=CCN(C(=O)[C@H]4N(CCCCCO)C(=O)[C@@H]3C2C(=O)O1)c5ccc6ccccc6c5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 L14 compound treatment 515960.0 134000.0 0.67 413020.0 49400.0 0.23 0.6374 0.8998 3187696 PK04_101230 CCCCCN(CC=C)C(=O)C(N(C(=O)/C=C\C(=O)O)c1c(Cl)cccc1CO)c2cccs2 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 L15 mock treatment 334250.0 -47700.0 -0.24 485950.0 122000.0 0.58 0.2382 0.3825 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 L16 mock treatment 507120.0 125000.0 0.63 238690.0 -125000.0 -0.59 0.0263 0.0307 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 L17 compound treatment 458240.0 76300.0 0.38 310720.0 -52900.0 -0.25 0.0933 0.205 3187697 PK04_101231 CC1CC/C=C\[C@H]2OC34C=CCN(C(=O)[C@H]4N(CCCCCO)C(=O)[C@]3(C)C2C(=O)O1)c5ccc(Cl)cc5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 L18 compound treatment 482560.0 101000.0 0.5 331620.0 -32000.0 -0.15 0.2487 0.4741 3187698 PK04_101232 CC(C)(C)N(CC=C)C(=O)C(N(C(=O)/C=C\C(=O)O)c1ccc(CCO)cc1)c2cccs2 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 L19 compound treatment 222150.0 -160000.0 -0.8 285390.0 -78300.0 -0.37 -0.8248 -0.9382 3069900 PK04_101233 CCN(CC)c1ccc(cc1)N2CC=CC34O[C@@H]5/C=C\CCC(C)OC(=O)C5[C@H]4C(=O)N(CCCCCO)[C@@H]3C2=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 L20 compound treatment 330050.0 -51900.0 -0.26 323930.0 -39700.0 -0.19 -0.3155 -0.9871 3187698 PK04_101234 CC(C)(C)N(CC=C)C(=O)C(N(C(=O)/C=C\C(=O)O)c1ccc(CCO)cc1)c2cccs2 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 L21 compound treatment 465720.0 83700.0 0.42 381990.0 18300.0 0.09 0.3567 0.8353 3187699 PK04_101235 CC1CC/C=C\[C@H]2OC34C=CCN(Cc5ccccc5)C(=O)[C@H]4N(CCCCCCO)C(=O)[C@@H]3C2C(=O)O1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 L22 compound treatment 459620.0 77600.0 0.39 385280.0 21600.0 0.1 0.3461 0.8634 3187700 PK04_101236 COc1ccc(cc1)N(CC=C)C(=O)C(N(C(=O)/C=C\C(=O)O)c2ccc(CCO)cc2)c3cccs3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 L23 mock treatment 381680.0 -299.0 0.0 383300.0 19600.0 0.09 0.0643 0.6956 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 L24 mock treatment 349790.0 -32200.0 -0.16 296250.0 -67400.0 -0.32 -0.3379 -0.9505 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 M01 compound treatment 474830.0 92900.0 0.46 430730.0 67100.0 0.32 0.551 0.9824 3187701 PK04_101237 CCN(CC)c1ccc(cc1)N2CC=CC34O[C@@H]5C=CCOC(=O)[C@@H]5[C@H]4C(=O)N(CCCCCCO)[C@@H]3C2=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 M02 compound treatment 381680.0 -299.0 0.0 155480.0 -208000.0 -0.98 -0.6934 -0.7082 3069926 PK04_101238 CC(C)N1CC=CC23O[C@@H]4/C=C\CCC(C)OC(=O)C4[C@H]3C(=O)N(C(C)CO)[C@@H]2C1=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 M03 compound treatment 222910.0 -159000.0 -0.79 505560.0 142000.0 0.67 -0.0898 -0.0865 3187702 PK04_101239 OCCCCCCN1[C@@H]2C(=O)N(Cc3ccccc3)CC=CC42O[C@@H]5C=CCCOC(=O)C5[C@H]4C1=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 M04 compound treatment 144160.0 -238000.0 -1.19 453370.0 89700.0 0.42 -0.5415 -0.4296 3069927 PK04_101240 CCCCCN1CC=CC23O[C@@H]4/C=C\CCC(C)OC(=O)C4[C@H]3C(=O)N(C(C)CO)[C@@H]2C1=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 M05 compound treatment 469760.0 87800.0 0.44 512720.0 149000.0 0.7 0.8058 0.9744 3187703 PK04_101241 CC(C)N1CC=CC23O[C@@H]4C=CCCOC(=O)C4[C@H]3C(=O)N(CCCCCCO)[C@@H]2C1=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 M06 compound treatment 495200.0 113000.0 0.57 301600.0 -62100.0 -0.29 0.1935 0.304 3187824 PK04_101242 CC(CO)N1[C@@H]2C(=O)N(Cn3nnc4ccccc34)CC=CC52O[C@@H]6/C=C\CCC(C)OC(=O)C6[C@H]5C1=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 M07 compound treatment 487640.0 106000.0 0.53 177960.0 -186000.0 -0.87 -0.2445 -0.2396 3069928 PK04_101243 CCCCCN1CC=CC23O[C@@H]4C=CCCOC(=O)C4[C@H]3C(=O)N(CCCCCCO)[C@@H]2C1=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 M08 compound treatment 483920.0 102000.0 0.51 365730.0 2080.0 0.01 0.3669 0.7205 3187825 PK04_101244 CCCCN1CC=CC23O[C@@H]4/C=C\CCC(C)OC(=O)C4[C@H]3C(=O)N(C(C)CO)[C@@H]2C1=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 M09 mock treatment 267290.0 -115000.0 -0.57 439460.0 75800.0 0.36 -0.1529 -0.2266 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 M10 mock treatment 490510.0 109000.0 0.54 232870.0 -131000.0 -0.62 -0.0517 -0.063 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 M11 compound treatment 237050.0 -145000.0 -0.72 184990.0 -179000.0 -0.84 -1.1061 -0.9972 3187826 PK04_101245 OCCCCCCN1[C@@H]2C(=O)N(Cn3nnc4ccccc34)CC=CC52O[C@@H]6C=CCCOC(=O)C6[C@H]5C1=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 M12 compound treatment 369960.0 -12000.0 -0.06 281790.0 -81900.0 -0.39 -0.3147 -0.8076 3069929 PK04_101246 CC(CO)N1[C@@H]2C(=O)N(CC=CC32O[C@@H]4/C=C\CCC(C)OC(=O)C4[C@H]3C1=O)C(C)(C)C 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 M13 mock treatment 289760.0 -92200.0 -0.46 317970.0 -45700.0 -0.21 -0.4776 -0.9398 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 M14 mock treatment 478260.0 96300.0 0.48 407770.0 44100.0 0.21 0.4868 0.9294 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 M15 compound treatment 430890.0 48900.0 0.24 198130.0 -166000.0 -0.78 -0.3778 -0.463 3187827 PK04_101247 CCCCN1CC=CC23O[C@@H]4C=CCCOC(=O)C4[C@H]3C(=O)N(CCCCCCO)[C@@H]2C1=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 M16 compound treatment 358460.0 -23500.0 -0.12 211590.0 -152000.0 -0.72 -0.5888 -0.8124 3187828 PK04_101248 CC(CO)N1[C@@H]2C(=O)N(CCN3CCOCC3)CC=CC42O[C@@H]5/C=C\CCC(C)OC(=O)C5[C@H]4C1=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 M17 compound treatment 452640.0 70700.0 0.35 267520.0 -96100.0 -0.45 -0.0702 -0.1224 3069930 PK04_101249 CC(C)(C)N1CC=CC23O[C@@H]4C=CCCOC(=O)C4[C@H]3C(=O)N(CCCCCCO)[C@@H]2C1=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 M18 compound treatment 313570.0 -68400.0 -0.34 428450.0 64800.0 0.3 -0.0261 -0.057 3187829 PK04_101250 CC(CO)N1[C@@H]2C(=O)N(CC=CC32O[C@@H]4/C=C\CCC(C)OC(=O)C4[C@H]3C1=O)c5ccc6ccccc6c5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 M19 compound treatment 454970.0 73000.0 0.36 366560.0 2910.0 0.01 0.2674 0.7331 3069931 PK04_101251 OCCCCCCN1[C@@H]2C(=O)N(CCN3CCOCC3)CC=CC42O[C@@H]5C=CCCOC(=O)C5[C@H]4C1=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 M20 compound treatment 482670.0 101000.0 0.5 382720.0 19100.0 0.09 0.419 0.8203 3187830 PK04_101252 CC(CO)N1[C@@H]2C(=O)N(CC=CC32O[C@@H]4/C=C\CCC(C)OC(=O)C4[C@@]3(C)C1=O)c5ccc(Cl)cc5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 M21 compound treatment 418340.0 36400.0 0.18 361440.0 -2210.0 -0.01 0.121 0.6654 3187831 PK04_101253 OCCCCCCN1[C@@H]2C(=O)N(CC=CC32O[C@@H]4C=CCCOC(=O)C4[C@H]3C1=O)c5ccc6ccccc6c5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 M22 compound treatment 328210.0 -53800.0 -0.27 442630.0 79000.0 0.37 0.0728 0.1588 3069932 PK04_101254 CCN(CC)c1ccc(cc1)N2CC=CC34O[C@@H]5/C=C\CCC(C)OC(=O)C5[C@H]4C(=O)N(C(C)CO)[C@@H]3C2=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 M23 compound treatment 424400.0 42400.0 0.21 382940.0 19300.0 0.09 0.214 0.9283 3187832 PK04_101255 OCCCCCCN1[C@@H]2C(=O)N(CC=CC32O[C@@H]4C=CCCOC(=O)C4[C@H]3C1=O)c5ccc(Cl)cc5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 M24 compound treatment 382990.0 1010.0 0.01 165560.0 -198000.0 -0.93 -0.6553 -0.7033 3187833 PK04_101256 CC(CO)N1[C@@H]2C(=O)N(Cc3ccccc3)CC=CC42O[C@@H]5/C=C\CCCOC(=O)C5[C@H]4C1=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 N01 compound treatment 501230.0 119000.0 0.6 475360.0 112000.0 0.53 0.7927 0.998 3069933 PK04_101257 CC(C)N1CC=CC23O[C@@H]4/C=C\CCC(C)OC(=O)C4[C@H]3C(=O)N(CCCCCCO)[C@@H]2C1=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 N02 compound treatment 160760.0 -221000.0 -1.1 503810.0 140000.0 0.66 -0.3151 -0.2449 3187700 PK04_101258 COc1ccc(cc1)N(CC=C)C(=O)C(N(C(=O)/C=C\C(=O)O)c2ccc(CCO)cc2)c3cccs3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 N03 compound treatment 165280.0 -217000.0 -1.08 463400.0 99700.0 0.47 -0.4336 -0.3675 3187834 PK04_101259 CCCCCN1CC=CC23O[C@@H]4/C=C\CCC(C)OC(=O)C4[C@H]3C(=O)N(CCCCCCO)[C@@H]2C1=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 N04 compound treatment 532220.0 150000.0 0.75 359330.0 -4320.0 -0.02 0.5162 0.6877 3069934 PK04_101260 OCCc1ccc(cc1)N(C(C(=O)N(CC=C)Cc2ccccc2)c3cccs3)C(=O)/C=C\C(=O)O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 N05 compound treatment 368700.0 -13300.0 -0.07 482240.0 119000.0 0.56 0.3475 0.6187 3187835 PK04_101261 CC1CC/C=C\[C@H]2OC34C=CCN(Cn5nnc6ccccc56)C(=O)[C@H]4N(CCCCCCO)C(=O)[C@@H]3C2C(=O)O1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 N06 compound treatment 284590.0 -97400.0 -0.49 486690.0 123000.0 0.58 0.0653 0.0863 3069934 PK04_101262 OCCc1ccc(cc1)N(C(C(=O)N(CC=C)Cc2ccccc2)c3cccs3)C(=O)/C=C\C(=O)O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 N07 compound treatment 499650.0 118000.0 0.59 356020.0 -7630.0 -0.04 0.3902 0.6627 3187836 PK04_101263 CCCCN1CC=CC23O[C@@H]4/C=C\CCC(C)OC(=O)C4[C@H]3C(=O)N(CCCCCCO)[C@@H]2C1=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 N08 compound treatment 470680.0 88700.0 0.44 193410.0 -170000.0 -0.8 -0.253 -0.2764 3069935 PK04_101264 CCCCN(CC=C)C(=O)C(N(C(=O)/C=C\C(=O)O)c1ccc(CCO)cc1)c2cccs2 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 N09 mock treatment 336570.0 -45400.0 -0.23 148740.0 -215000.0 -1.01 -0.8752 -0.8447 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 N10 mock treatment 320890.0 -61100.0 -0.31 219680.0 -144000.0 -0.68 -0.6946 -0.9352 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 N11 compound treatment 500350.0 118000.0 0.59 170880.0 -193000.0 -0.91 -0.2231 -0.2061 3187837 PK04_101265 CC1CC/C=C\[C@H]2OC34C=CCN(C(=O)[C@H]4N(CCCCCCO)C(=O)[C@@H]3C2C(=O)O1)C(C)(C)C 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 N12 compound treatment 263770.0 -118000.0 -0.59 477230.0 114000.0 0.53 -0.0397 -0.0499 3069935 PK04_101266 CCCCN(CC=C)C(=O)C(N(C(=O)/C=C\C(=O)O)c1ccc(CCO)cc1)c2cccs2 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 N13 mock treatment 316280.0 -65700.0 -0.33 368250.0 4600.0 0.02 -0.2167 -0.6591 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 N14 mock treatment 503390.0 121000.0 0.61 242620.0 -121000.0 -0.57 0.0262 0.0315 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 N15 compound treatment 489530.0 108000.0 0.54 422340.0 58700.0 0.28 0.575 0.9521 3069936 PK04_101267 CC1CC/C=C\[C@H]2OC34C=CCN(CCN5CCOCC5)C(=O)[C@H]4N(CCCCCCO)C(=O)[C@@H]3C2C(=O)O1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 N16 compound treatment 281640.0 -100000.0 -0.5 308060.0 -55600.0 -0.26 -0.5393 -0.954 3187838 PK04_101268 CCCCCN(CC=C)C(=O)C(N(C(=O)/C=C\C(=O)O)c1ccc(CCO)cc1)c2cccs2 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 N17 compound treatment 342780.0 -39200.0 -0.2 165000.0 -199000.0 -0.93 -0.7992 -0.8371 3187839 PK04_101269 CC1CC/C=C\[C@H]2OC34C=CCN(C(=O)[C@H]4N(CCCCCCO)C(=O)[C@]3(C)C2C(=O)O1)c5ccc(Cl)cc5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 N18 compound treatment 317600.0 -64400.0 -0.32 343150.0 -20500.0 -0.1 -0.2956 -0.8805 3187838 PK04_101270 CCCCCN(CC=C)C(=O)C(N(C(=O)/C=C\C(=O)O)c1ccc(CCO)cc1)c2cccs2 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 N19 compound treatment 391550.0 9570.0 0.05 310080.0 -53600.0 -0.25 -0.1444 -0.5629 3187840 PK04_101271 CCN(CC)c1ccc(cc1)N2CC=CC34O[C@@H]5/C=C\CCC(C)OC(=O)C5[C@H]4C(=O)N(CCCCCCO)[C@@H]3C2=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 N20 compound treatment 358750.0 -23200.0 -0.12 392010.0 28400.0 0.13 0.0123 0.0694 3187841 PK04_101272 CC(C)(C)N(CC=C)C(=O)C(N(CCOCCO)C(=O)/C=C\C(=O)O)c1cccs1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 N21 compound treatment 290610.0 -91400.0 -0.46 284730.0 -78900.0 -0.37 -0.5852 -0.9948 3069973 PK04_101273 OCCCCCCN1[C@@H]2C(=O)N(Cc3ccccc3)CC=CC42O[C@@H]5/C=C\CCCOC(=O)C5[C@H]4C1=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 N22 compound treatment 348480.0 -33500.0 -0.17 472210.0 109000.0 0.51 0.2427 0.4518 3187841 PK04_101274 CC(C)(C)N(CC=C)C(=O)C(N(CCOCCO)C(=O)/C=C\C(=O)O)c1cccs1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 N23 compound treatment 451160.0 69200.0 0.35 229630.0 -134000.0 -0.63 -0.2014 -0.2802 3187842 PK04_101275 CC(C)N1CC=CC23O[C@@H]4/C=C\CCCOC(=O)C4[C@H]3C(=O)N(CCCCCCO)[C@@H]2C1=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 N24 compound treatment 530360.0 148000.0 0.74 223250.0 -140000.0 -0.66 0.057 0.0575 3187843 PK04_101276 COc1ccc(cc1)N(CC=C)C(=O)C(N(CCOCCO)C(=O)/C=C\C(=O)O)c2cccs2 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 O01 compound treatment 223840.0 -158000.0 -0.79 361980.0 -1670.0 -0.01 -0.5641 -0.7141 3069974 PK04_101277 CCN(CC)c1ccc(cc1)N2CC=CC34O[C@@H]5C=CCCOC(=O)C5[C@H]4C(=O)N(CCCCCCO)[C@@H]3C2=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 O02 compound treatment 490090.0 108000.0 0.54 352260.0 -11400.0 -0.05 0.3439 0.6338 3187957 PK04_101278 CC(C)N1CC=CC23O[C@@H]4/C=C\CCCOC(=O)C4[C@H]3C(=O)N(C(C)CO)[C@@H]2C1=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 O03 compound treatment 431120.0 49100.0 0.25 484220.0 121000.0 0.57 0.5745 0.9298 3187958 PK04_101279 OCCCCCN1[C@@H]2C(=O)N(Cc3ccccc3)CC=CC42O[C@@H]5C=CCCOC(=O)C5[C@H]4C1=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 O04 compound treatment 449550.0 67600.0 0.34 447100.0 83400.0 0.39 0.5162 0.9972 3069975 PK04_101280 CCCCCN1CC=CC23O[C@@H]4/C=C\CCCOC(=O)C4[C@H]3C(=O)N(C(C)CO)[C@@H]2C1=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 O05 compound treatment 489280.0 107000.0 0.54 380370.0 16700.0 0.08 0.4345 0.8023 3187959 PK04_101281 CC(C)N1CC=CC23O[C@@H]4C=CCCOC(=O)C4[C@H]3C(=O)N(CCCCCO)[C@@H]2C1=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 O06 compound treatment 161830.0 -220000.0 -1.1 252960.0 -111000.0 -0.52 -1.1457 -0.9417 3187960 PK04_101282 CC(CO)N1[C@@H]2C(=O)N(Cn3nnc4ccccc34)CC=CC52O[C@@H]6/C=C\CCCOC(=O)C6[C@H]5C1=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 O07 compound treatment 521440.0 139000.0 0.7 309020.0 -54600.0 -0.26 0.3108 0.4186 3069976 PK04_101283 CCCCCN1CC=CC23O[C@@H]4C=CCCOC(=O)C4[C@H]3C(=O)N(CCCCCO)[C@@H]2C1=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 O08 compound treatment 447880.0 65900.0 0.33 378470.0 14800.0 0.07 0.282 0.8382 3187961 PK04_101284 CCCCN1CC=CC23O[C@@H]4/C=C\CCCOC(=O)C4[C@H]3C(=O)N(C(C)CO)[C@@H]2C1=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 O09 compound treatment 309230.0 -72700.0 -0.36 315640.0 -48000.0 -0.23 -0.4166 -0.9738 3069977 PK04_101285 OCCCCCN1[C@@H]2C(=O)N(Cn3nnc4ccccc34)CC=CC52O[C@@H]6C=CCCOC(=O)C6[C@H]5C1=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 O10 compound treatment 450920.0 68900.0 0.34 397310.0 33700.0 0.16 0.3554 0.9378 3187962 PK04_101286 CC(CO)N1[C@@H]2C(=O)N(CC=CC32O[C@@H]4/C=C\CCCOC(=O)C4[C@H]3C1=O)C(C)(C)C 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 O11 mock treatment 289950.0 -92000.0 -0.46 546480.0 183000.0 0.86 0.2831 0.2903 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 O12 mock treatment 316760.0 -65200.0 -0.33 326420.0 -37200.0 -0.18 -0.3542 -0.9577 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 O13 compound treatment 435330.0 53400.0 0.27 417390.0 53700.0 0.25 0.3671 0.9997 3187963 PK04_101287 CCCCN1CC=CC23O[C@@H]4C=CCCOC(=O)C4[C@H]3C(=O)N(CCCCCO)[C@@H]2C1=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 O14 compound treatment 318650.0 -63300.0 -0.32 189280.0 -174000.0 -0.82 -0.8036 -0.9142 3069978 PK04_101288 CC(CO)N1[C@@H]2C(=O)N(CCN3CCOCC3)CC=CC42O[C@@H]5/C=C\CCCOC(=O)C5[C@H]4C1=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 O15 compound treatment 338620.0 -43400.0 -0.22 334670.0 -29000.0 -0.14 -0.2495 -0.9751 3187964 PK04_101289 CC(C)(C)N1CC=CC23O[C@@H]4C=CCCOC(=O)C4[C@H]3C(=O)N(CCCCCO)[C@@H]2C1=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 O16 compound treatment 438800.0 56800.0 0.28 466560.0 103000.0 0.48 0.5429 0.9676 3187965 PK04_101290 CC(CO)N1[C@@H]2C(=O)N(CC=CC32O[C@@H]4/C=C\CCCOC(=O)C4[C@H]3C1=O)c5ccc6ccccc6c5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 O17 compound treatment 429160.0 47200.0 0.24 373550.0 9900.0 0.05 0.1995 0.8307 3069979 PK04_101291 OCCCCCN1[C@@H]2C(=O)N(CCN3CCOCC3)CC=CC42O[C@@H]5C=CCCOC(=O)C5[C@H]4C1=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 O18 compound treatment 475360.0 93400.0 0.47 241960.0 -122000.0 -0.57 -0.075 -0.1015 3187966 PK04_101292 CC(CO)N1[C@@H]2C(=O)N(CC=CC32O[C@@H]4/C=C\CCCOC(=O)C4[C@@]3(C)C1=O)c5ccc(Cl)cc5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 O19 compound treatment 365120.0 -16900.0 -0.08 316180.0 -47500.0 -0.22 -0.2174 -0.9111 3187967 PK04_101293 OCCCCCN1[C@@H]2C(=O)N(CC=CC32O[C@@H]4C=CCCOC(=O)C4[C@H]3C1=O)c5ccc6ccccc6c5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 O20 compound treatment 387700.0 5720.0 0.03 306570.0 -57100.0 -0.27 -0.1697 -0.6283 3069980 PK04_101294 CCN(CC)c1ccc(cc1)N2CC=CC34O[C@@H]5/C=C\CCCOC(=O)C5[C@H]4C(=O)N(C(C)CO)[C@@H]3C2=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 O21 compound treatment 379090.0 -2890.0 -0.01 392120.0 28500.0 0.13 0.0845 0.6273 3187968 PK04_101295 OCCCCCN1[C@@H]2C(=O)N(CC=CC32O[C@@H]4C=CCCOC(=O)C4[C@H]3C1=O)c5ccc(Cl)cc5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 O22 compound treatment 369800.0 -12200.0 -0.06 434490.0 70800.0 0.33 0.1926 0.5686 3069981 PK04_101296 OCCN1[C@@H]2C(=O)N(Cc3ccccc3)CC=CC42O[C@@H]5/C=C\CCCOC(=O)C5[C@H]4C1=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 O23 compound treatment 401050.0 19100.0 0.1 349610.0 -14000.0 -0.07 0.0206 0.1781 3187969 PK04_101297 CCN(CC)c1ccc(cc1)N2CC=CC34O[C@@H]5C=CCCOC(=O)C5[C@H]4C(=O)N(CCCCCO)[C@@H]3C2=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 O24 compound treatment 279770.0 -102000.0 -0.51 537150.0 173000.0 0.82 0.2161 0.2245 3187970 PK04_101298 CC(C)N1CC=CC23O[C@@H]4/C=C\CCCOC(=O)C4[C@H]3C(=O)N(CCO)[C@@H]2C1=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 P01 compound treatment 206400.0 -176000.0 -0.88 185210.0 -178000.0 -0.84 -1.2136 -0.9998 3069982 PK04_101299 CCCCCN1CC=CC23O[C@@H]4/C=C\CCCOC(=O)C4[C@H]3C(=O)N(CCCCCCO)[C@@H]2C1=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 P02 compound treatment 180340.0 -202000.0 -1.01 455580.0 91900.0 0.43 -0.4064 -0.3708 3187843 PK04_101300 COc1ccc(cc1)N(CC=C)C(=O)C(N(CCOCCO)C(=O)/C=C\C(=O)O)c2cccs2 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 P03 compound treatment 384700.0 2720.0 0.01 251440.0 -112000.0 -0.53 -0.3636 -0.6887 3187971 PK04_101301 OCCCCCCN1[C@@H]2C(=O)N(Cn3nnc4ccccc34)CC=CC52O[C@@H]6/C=C\CCCOC(=O)C6[C@H]5C1=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 P04 compound treatment 123310.0 -259000.0 -1.29 149070.0 -215000.0 -1.01 -1.6272 -0.9925 3069983 PK04_101302 OCCOCCN(C(C(=O)N(CC=C)Cc1ccccc1)c2cccs2)C(=O)/C=C\C(=O)O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 P05 compound treatment 185950.0 -196000.0 -0.98 146620.0 -217000.0 -1.02 -1.4142 -0.9998 3187972 PK04_101303 CCCCN1CC=CC23O[C@@H]4/C=C\CCCOC(=O)C4[C@H]3C(=O)N(CCCCCCO)[C@@H]2C1=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 P06 compound treatment 237200.0 -145000.0 -0.72 245490.0 -118000.0 -0.56 -0.9043 -0.9916 3187973 PK04_101304 OCCOCCc1ccc(cc1)N(C(C(=O)N(CC=C)Cc2ccccc2)c3cccs3)C(=O)/C=C\C(=O)O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 P07 compound treatment 163360.0 -219000.0 -1.09 184830.0 -179000.0 -0.84 -1.3669 -0.9917 3069985 PK04_101305 CC(C)(C)N1CC=CC23O[C@@H]4/C=C\CCCOC(=O)C4[C@H]3C(=O)N(CCCCCCO)[C@@H]2C1=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 P08 compound treatment 193200.0 -189000.0 -0.94 419250.0 55600.0 0.26 -0.4818 -0.4924 3187974 PK04_101306 CCCCN(CC=C)C(=O)C(N(CCOCCO)C(=O)/C=C\C(=O)O)c1cccs1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 P09 compound treatment 282560.0 -99400.0 -0.5 293670.0 -70000.0 -0.33 -0.5839 -0.9801 3187975 PK04_101307 OCCCCCCN1[C@@H]2C(=O)N(CCN3CCOCC3)CC=CC42O[C@@H]5/C=C\CCCOC(=O)C5[C@H]4C1=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 P10 compound treatment 229500.0 -152000.0 -0.76 180990.0 -183000.0 -0.86 -1.146 -0.9982 3187974 PK04_101308 CCCCN(CC=C)C(=O)C(N(CCOCCO)C(=O)/C=C\C(=O)O)c1cccs1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 P11 mock treatment 237330.0 -145000.0 -0.72 211280.0 -152000.0 -0.72 -1.0176 -1.0 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 P12 mock treatment 226760.0 -155000.0 -0.78 258770.0 -105000.0 -0.49 -0.897 -0.9762 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 P13 compound treatment 211720.0 -170000.0 -0.85 349650.0 -14000.0 -0.07 -0.6479 -0.7596 3069986 PK04_101309 OCCCCCCN1[C@@H]2C(=O)N(CC=CC32O[C@@H]4/C=C\CCCOC(=O)C4[C@H]3C1=O)c5ccc6ccccc6c5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 P14 compound treatment 206130.0 -176000.0 -0.88 209930.0 -154000.0 -0.72 -1.1323 -0.9953 3069301 PK04_101310 CCCCCN(CC=C)C(=O)C(N(CCOCCO)C(=O)/C=C\C(=O)O)c1cccs1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 P15 compound treatment 371540.0 -10400.0 -0.05 245700.0 -118000.0 -0.55 -0.4292 -0.7702 3187976 PK04_101311 C[C@]12C3[C@H](OC24C=CCN(C(=O)[C@H]4N(CCCCCCO)C1=O)c5ccc(Cl)cc5)/C=C\CCCOC3=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 P16 compound treatment 319160.0 -62800.0 -0.31 253230.0 -110000.0 -0.52 -0.5891 -0.9709 3069301 PK04_101312 CCCCCN(CC=C)C(=O)C(N(CCOCCO)C(=O)/C=C\C(=O)O)c1cccs1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 P17 compound treatment 383710.0 1730.0 0.01 203760.0 -160000.0 -0.75 -0.5257 -0.6989 3187977 PK04_101313 CCN(CC)c1ccc(cc1)N2CC=CC34O[C@@H]5/C=C\CCCOC(=O)C5[C@H]4C(=O)N(CCCCCCO)[C@@H]3C2=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 P18 compound treatment 236710.0 -145000.0 -0.73 267620.0 -96000.0 -0.45 -0.8324 -0.974 3069302 PK04_101314 CC(C)(C)N(CC=C)C(=O)C(N(C(=O)/C=C\C(=O)O)C(C)(C)CO)c1cccs1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 P19 compound treatment 265830.0 -116000.0 -0.58 171480.0 -192000.0 -0.9 -1.0494 -0.977 3189130 PK04_101315 CC(C)(C)N(CC=C)C(=O)C1N(C(=O)C2C(C3OC12C=C3)C(=O)O)c4c(Cl)cccc4CO 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 P20 compound treatment 260010.0 -122000.0 -0.61 352550.0 -11100.0 -0.05 -0.4677 -0.7649 3069302 PK04_101316 CC(C)(C)N(CC=C)C(=O)C(N(C(=O)/C=C\C(=O)O)C(C)(C)CO)c1cccs1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 P21 compound treatment 302080.0 -79900.0 -0.4 364690.0 1040.0 0.0 -0.2787 -0.6984 3189131 PK04_101317 COc1ccc(cc1)N(CC=C)C(=O)C2N(C(=O)C3C(C4OC23C=C4)C(=O)O)c5c(Cl)cccc5CO 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 P22 compound treatment 229720.0 -152000.0 -0.76 191700.0 -172000.0 -0.81 -1.1096 -0.9995 3069303 PK04_101318 COc1ccc(cc1)N(CC=C)C(=O)C(N(C(=O)/C=C\C(=O)O)C(C)(C)CO)c2cccs2 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 P23 compound treatment 215120.0 -167000.0 -0.83 170340.0 -193000.0 -0.91 -1.2322 -0.9991 3069685 PK04_101319 OCc1cccc(Cl)c1N2C(C(=O)N(CC=C)Cc3ccccc3)C4(OC5C=C4)C(C5C(=O)O)C2=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2101 P24 compound treatment 275940.0 -106000.0 -0.53 411870.0 48200.0 0.23 -0.2141 -0.3717 3069303 PK04_101320 COc1ccc(cc1)N(CC=C)C(=O)C(N(C(=O)/C=C\C(=O)O)C(C)(C)CO)c2cccs2 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 A01 compound treatment 164360.0 -351000.0 -1.75 226530.0 -269000.0 -1.27 -2.1352 -0.9871 3188092 PK04_102001 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCn4cc(CCO)nn4)C(=O)N(CC=C)c5ccccc53 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 A02 compound treatment 66190.0 -449000.0 -2.24 72040.0 -423000.0 -1.99 -2.9958 -0.9982 3188093 PK04_102002 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCO)C(=O)N(Cc4ccccc4)c5ccc(cc53)N6CCCCC6=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 A03 compound treatment 240800.0 -275000.0 -1.37 132000.0 -363000.0 -1.71 -2.1797 -0.9941 3069304 PK04_102003 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCO)C(=O)N(CC=C)c4ccccc43 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 A04 compound treatment 336180.0 -179000.0 -0.9 300850.0 -195000.0 -0.92 -1.2812 -0.9999 3188094 PK04_102004 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCn4cc(CCO)nn4)C(=O)N(Cc5ccc(cc5)N6C(=O)c7cccc8cccc6c78)c9ccccc93 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 A05 compound treatment 198400.0 -317000.0 -1.58 417450.0 -78000.0 -0.37 -1.38 -0.8484 3069305 PK04_102005 COc1ccc(cc1)[Si](C)(C)[C@H](CC(=O)N2CCC[C@H]2CO)/C=C/C 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 A06 compound treatment 152430.0 -363000.0 -1.81 168430.0 -327000.0 -1.54 -2.3706 -0.9966 3188095 PK04_102006 COc1ccc(cc1)C(=O)Nc2cccc(CN3C(=O)[C@]4(O[C@H](CCn5cc(nn5)[C@H](O)c6ccccc6)[C@H]([C@@H]4C)[Si](C)(C)c7ccc(OC)cc7)c8ccccc38)c2 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 A07 compound treatment 104980.0 -411000.0 -2.05 137690.0 -358000.0 -1.68 -2.6404 -0.9952 3069306 PK04_102007 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCn4cc(CCO)nn4)C(=O)N(c5ccccc53)c6ccccc6 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 A08 compound treatment 104970.0 -411000.0 -2.05 92480.0 -403000.0 -1.9 -2.7908 -0.9992 3188096 PK04_102008 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCO)C(=O)N(Cc4ccc(NC(=O)C)cc4)c5ccccc53 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 A09 compound treatment 318320.0 -197000.0 -0.99 198330.0 -297000.0 -1.4 -1.6853 -0.9854 3188097 PK04_102009 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CC(=O)N4Cc5ccccc5C[C@H]4CO)C(=O)N(C)c6ccccc63 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 A10 compound treatment 136510.0 -379000.0 -1.89 102090.0 -393000.0 -1.85 -2.6475 -0.9999 3069307 PK04_102010 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCO)C(=O)N(Cc4ccccc4)c5ccc(cc53)N6CCOC6=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 A11 compound treatment 443300.0 -72400.0 -0.36 465120.0 -30400.0 -0.14 -0.3566 -0.9175 3188098 PK04_102011 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCn4cc(nn4)[C@H](O)c5ccccc5)C(=O)N(c6ccccc63)c7ccccc7 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 A12 compound treatment 115650.0 -400000.0 -2.0 159570.0 -336000.0 -1.58 -2.53 -0.9933 3069308 PK04_102012 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCO)C(=O)N(Cc4cccc(c4)N(C=O)c5ccccc5)c6ccccc63 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 A13 mock treatment 460270.0 -55400.0 -0.28 424800.0 -70700.0 -0.33 -0.4307 -0.9958 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 A14 mock treatment 331890.0 -184000.0 -0.92 396540.0 -99000.0 -0.47 -0.9781 -0.9505 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 A15 compound treatment 120000.0 -396000.0 -1.98 165990.0 -330000.0 -1.55 -2.4933 -0.9928 3188099 PK04_102013 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCO)C(=O)N(c4ccccc43)c5ccccc5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 A16 compound treatment 255280.0 -260000.0 -1.3 160170.0 -335000.0 -1.58 -2.0349 -0.9954 3188100 PK04_102014 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCn4cc(CCO)nn4)C(=O)N(Cc5cccc(c5)N6C(=O)c7cccc8cccc6c78)c9ccccc93 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 A17 compound treatment 134240.0 -381000.0 -1.91 124450.0 -371000.0 -1.75 -2.5811 -0.999 3069309 PK04_102015 COc1ccc(cc1)C(=O)Nc2ccc3N(Cc4ccccc4)C(=O)[C@]5(O[C@H](CCO)[C@H]([C@@H]5C)[Si](C)(C)c6ccc(OC)cc6)c3c2 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 A18 compound treatment 143140.0 -373000.0 -1.86 119730.0 -376000.0 -1.77 -2.5654 -0.9997 3188101 PK04_102016 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCO)C(=O)N(Cc4ccc(NC(=O)[C@H](C)O)cc4)c5ccccc53 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 A19 compound treatment 91010.0 -425000.0 -2.12 100650.0 -395000.0 -1.86 -2.813 -0.9978 3069310 PK04_102017 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCO)C(=O)N(CC=C)c4ccc(cc43)N5C(=O)COc6ccccc56 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 A20 compound treatment 124490.0 -391000.0 -1.95 124250.0 -371000.0 -1.75 -2.6162 -0.9984 3188102 PK04_102018 COc1ccc(cc1)C(=O)Nc2ccc3N(Cc4ccccc4)C(=O)[C@@]5(O[C@@H](CCO)[C@@H]([C@H]5C)[Si](C)(C)c6ccc(OC)cc6)c3c2 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 A21 compound treatment 346880.0 -169000.0 -0.84 268920.0 -227000.0 -1.07 -1.3497 -0.9933 3188103 PK04_102019 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCn4cc(nn4)[C@H](O)c5ccccc5)C(=O)N(Cc6ccc(cc6)N7C(=O)c8cccc9cccc7c89)c%10ccccc%103 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 A22 compound treatment 96290.0 -419000.0 -2.09 139330.0 -356000.0 -1.68 -2.6657 -0.9939 3069311 PK04_102020 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCO)C(=O)N(Cc4ccc(NC(=O)[C@H](C)O)cc4)c5ccccc53 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 A23 compound treatment 284020.0 -232000.0 -1.16 199550.0 -296000.0 -1.39 -1.8024 -0.9958 3188104 PK04_102021 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCn4cc(nn4)[C@H](O)c5ccccc5)C(=O)N(CC=C)c6ccc(cc63)N7CCOC7=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 A24 compound treatment 392220.0 -123000.0 -0.62 304330.0 -191000.0 -0.9 -1.0718 -0.9831 3188105 PK04_102022 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCn4cc(nn4)[C@H](O)c5ccccc5)C(=O)N(CC=C)c6ccc(cc63)N7CCOC7=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 B01 compound treatment 545760.0 30100.0 0.15 513310.0 17800.0 0.08 0.1656 0.9619 3069350 PK04_102023 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCO)C(=O)N(CC=C)c4ccc(cc43)N5CCC5=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 B02 compound treatment 260880.0 -255000.0 -1.27 261170.0 -234000.0 -1.1 -1.6792 -0.9974 3188106 PK04_102024 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCO)C(=O)N(Cc4ccc(cc4)N5CCC5=O)c6ccccc63 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 B03 compound treatment 437480.0 -78200.0 -0.39 498600.0 3110.0 0.01 -0.2658 -0.6802 3069351 PK04_102025 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CC(=O)N4CCC[C@H]4CO)C(=O)N(Cc5ccc(cc5)N6CCCCC6=O)c7ccccc73 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 B04 compound treatment 446670.0 -69000.0 -0.34 195520.0 -300000.0 -1.41 -1.2414 -0.8547 3188107 PK04_102026 COc1ccc(cc1)C(=O)Nc2cccc(CN3C(=O)[C@]4(O[C@H](CC(=O)N5Cc6ccccc6C[C@H]5CO)[C@H]([C@@H]4C)[Si](C)(C)c7ccc(OC)cc7)c8ccccc38)c2 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 B05 compound treatment 278510.0 -237000.0 -1.18 239360.0 -256000.0 -1.2 -1.6894 -1.0 3188221 PK04_102027 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CC(=O)N4CCC[C@H]4CO)C(=O)N(Cc5ccc(cc5)N6C(=O)c7cccc8cccc6c78)c9ccccc93 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 B06 compound treatment 240650.0 -275000.0 -1.37 391230.0 -104000.0 -0.49 -1.318 -0.9037 3069352 PK04_102028 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CC(=O)N(CCO)Cc4ccccc4)C(=O)N(Cc5cccc(I)c5)c6ccccc63 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 B07 compound treatment 239730.0 -276000.0 -1.38 324040.0 -171000.0 -0.81 -1.5447 -0.9674 3188222 PK04_102029 COc1ccc(cc1)C(=O)Nc2ccc(CN3C(=O)[C@]4(O[C@H](CC(=O)N(CCO)Cc5ccccc5)[C@H]([C@@H]4C)[Si](C)(C)c6ccc(OC)cc6)c7ccccc37)cc2 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 B08 compound treatment 202080.0 -314000.0 -1.57 370210.0 -125000.0 -0.59 -1.5242 -0.9108 3069353 PK04_102030 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CC(=O)N(CCO)Cc4ccccc4)C(=O)N(Cc5ccc(I)cc5)c6ccccc63 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 B09 compound treatment 315090.0 -201000.0 -1.0 318950.0 -177000.0 -0.83 -1.2955 -0.9957 3188223 PK04_102031 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CC(=O)N(CCO)Cc4ccccc4)C(=O)N(Cc5cccc(c5)N6CCOC6=O)c7ccccc73 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 B10 compound treatment 355540.0 -160000.0 -0.8 207410.0 -288000.0 -1.36 -1.5237 -0.9684 3188224 PK04_102032 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CC(=O)N4Cc5ccccc5C[C@H]4CO)C(=O)N(Cc6cccc(c6)N7CCOC7=O)c8ccccc83 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 B11 compound treatment 276480.0 -239000.0 -1.19 227120.0 -268000.0 -1.26 -1.7373 -0.9996 3069354 PK04_102033 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CC(=O)N4CCC[C@H]4CO)C(=O)N(Cc5ccc(cc5)N6C(=O)c7cccc8cccc6c78)c9ccccc93 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 B12 compound treatment 169440.0 -346000.0 -1.73 194750.0 -301000.0 -1.41 -2.223 -0.995 3188225 PK04_102034 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CC(=O)N4Cc5ccccc5C[C@H]4CO)C(=O)N(Cc6cccc(c6)N7CCCCC7=O)c8ccccc83 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 B13 mock treatment 502280.0 -13400.0 -0.07 513700.0 18200.0 0.09 0.0133 0.1224 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 B14 mock treatment 525810.0 10100.0 0.05 511780.0 16300.0 0.08 0.09 0.9799 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 B15 compound treatment 317500.0 -198000.0 -0.99 180400.0 -315000.0 -1.48 -1.7478 -0.9807 3188226 PK04_102035 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CC(=O)N(CCO)Cc4ccccc4)C(=O)N(Cc5ccc(cc5)N6C(=O)c7cccc8cccc6c78)c9ccccc93 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 B16 compound treatment 445280.0 -70400.0 -0.35 199890.0 -296000.0 -1.39 -1.2317 -0.8589 3069355 PK04_102036 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CC(=O)N4CCC[C@H]4CO)C(=O)N(Cc5cccc(I)c5)c6ccccc63 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 B17 compound treatment 218990.0 -297000.0 -1.48 175420.0 -320000.0 -1.51 -2.1123 -1.0 3188227 PK04_102037 COc1ccc(cc1)C(=O)Nc2ccc(CN3C(=O)[C@]4(O[C@H](CC(=O)N5Cc6ccccc6C[C@H]5CO)[C@H]([C@@H]4C)[Si](C)(C)c7ccc(OC)cc7)c8ccccc38)cc2 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 B18 compound treatment 160850.0 -355000.0 -1.77 143810.0 -352000.0 -1.65 -2.4228 -0.9994 3069356 PK04_102038 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CC(=O)N(CCO)Cc4ccccc4)C(=O)N(Cc5cccc(I)c5)c6ccccc63 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 B19 compound treatment 366400.0 -149000.0 -0.75 271320.0 -224000.0 -1.05 -1.2727 -0.9856 3188228 PK04_102039 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CC(=O)N4CCC[C@H]4CO)C(=O)N(Cc5cccc(c5)N6CCC6=O)c7ccccc73 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 B20 compound treatment 398880.0 -117000.0 -0.58 199000.0 -296000.0 -1.39 -1.3986 -0.9252 3188229 PK04_102040 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCn4cc(CCO)nn4)C(=O)N(Cc5cccc(c5)N6CCC6=O)c7ccccc73 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 B21 compound treatment 496700.0 -19000.0 -0.09 252000.0 -243000.0 -1.15 -0.8768 -0.763 3069357 PK04_102041 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCn4cc(nn4)[C@H](O)c5ccccc5)C(=O)N(C)c6c3cc(C)cc6Br 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 B22 compound treatment 242110.0 -274000.0 -1.37 252120.0 -243000.0 -1.14 -1.7755 -0.9961 3188230 PK04_102042 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CC(=O)N4Cc5ccccc5C[C@H]4CO)C(=O)N(Cc6cccc(I)c6)c7ccccc73 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 B23 compound treatment 311300.0 -204000.0 -1.02 194240.0 -301000.0 -1.42 -1.7237 -0.987 3069358 PK04_102043 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CC(=O)N4Cc5ccccc5C[C@H]4CO)C(=O)N(Cc6cccc(c6)N7C(=O)COc8ccccc78)c9ccccc93 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 B24 compound treatment 436640.0 -79000.0 -0.39 250010.0 -245000.0 -1.15 -1.0956 -0.8978 3188231 PK04_102044 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CC(=O)N4CCC[C@H]4CO)C(=O)N(Cc5ccc(I)cc5)c6ccccc63 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 C01 compound treatment 537890.0 22200.0 0.11 510010.0 14500.0 0.07 0.1268 0.9728 3188232 PK04_102045 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CC(=O)N4CCC[C@H]4CO)C(=O)N(c5ccccc53)c6ccccc6 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 C02 compound treatment 165300.0 -350000.0 -1.75 166510.0 -329000.0 -1.55 -2.3315 -0.9981 3069359 PK04_102046 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCO)C(=O)N(Cc4ccccc4)c5ccc(cc53)N6C(=O)COc7ccccc67 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 C03 compound treatment 326080.0 -190000.0 -0.95 174270.0 -321000.0 -1.51 -1.7379 -0.9747 3188233 PK04_102047 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CC(=O)N4Cc5ccccc5C[C@H]4CO)C(=O)N(c6ccccc63)c7ccccc7 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 C04 compound treatment 366000.0 -150000.0 -0.75 388640.0 -107000.0 -0.5 -0.8839 -0.9813 3188234 PK04_102048 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCn4cc(nn4)[C@H](O)c5ccccc5)C(=O)N(Cc6ccc(cc6)N7CCOC7=O)c8ccccc83 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 C05 compound treatment 452960.0 -62700.0 -0.31 503530.0 8040.0 0.04 -0.1947 -0.6173 3069360 PK04_102049 COc1ccc(cc1)[Si](C)(C)[C@H](CCn2cc(nn2)[C@H](O)c3ccccc3)/C=C/C 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 C06 compound treatment 10720.0 -505000.0 -2.52 11270.0 -484000.0 -2.28 -3.3938 -0.9987 3188235 PK04_102050 COc1ccc(cc1)C(=O)Nc2cccc(CN3C(=O)[C@]4(O[C@H](CCO)[C@H]([C@@H]4C)[Si](C)(C)c5ccc(OC)cc5)c6ccccc36)c2 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 C07 compound treatment 360530.0 -155000.0 -0.77 510250.0 14800.0 0.07 -0.4988 -0.6412 3069393 PK04_102051 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCn4cc(nn4)[C@H](O)c5ccccc5)C(=O)N(CC=C)c6ccccc63 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 C08 compound treatment 207400.0 -308000.0 -1.54 197700.0 -298000.0 -1.4 -2.0791 -0.9989 3188236 PK04_102052 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCO)C(=O)N(Cc4ccccc4)c5ccc(cc53)N6C(=O)c7ccccc7Oc8ccccc68 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 C09 compound treatment 112330.0 -403000.0 -2.01 149340.0 -346000.0 -1.63 -2.5757 -0.9944 3069394 PK04_102053 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCO)C(=O)N(C)c4c3cc(C)cc4Br 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 C10 compound treatment 124820.0 -391000.0 -1.95 106120.0 -389000.0 -1.83 -2.6754 -0.9995 3188352 PK04_102054 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCO)C(=O)N(Cc4ccc(cc4)N5C(=O)COc6ccccc56)c7ccccc73 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 C11 mock treatment 470040.0 -45600.0 -0.23 481020.0 -14500.0 -0.07 -0.2093 -0.8799 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 C12 mock treatment 463150.0 -52500.0 -0.26 380750.0 -115000.0 -0.54 -0.5671 -0.9451 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 C13 compound treatment 330150.0 -186000.0 -0.93 232680.0 -263000.0 -1.24 -1.5293 -0.9899 3188353 PK04_102055 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCn4cc(nn4)[C@H](O)c5ccccc5)C(=O)N(C)c6ccccc63 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 C14 compound treatment 68800.0 -447000.0 -2.23 53200.0 -442000.0 -2.08 -3.0492 -0.9994 3069395 PK04_102056 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCO)C(=O)N(CC=C)c4ccc(cc43)N5C(=O)c6ccccc6Oc7ccccc57 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 C15 mock treatment 499870.0 -15800.0 -0.08 438420.0 -57100.0 -0.27 -0.2456 -0.8778 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 C16 mock treatment 503600.0 -12100.0 -0.06 473220.0 -22300.0 -0.1 -0.1167 -0.9655 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 C17 compound treatment 183050.0 -333000.0 -1.66 127970.0 -368000.0 -1.73 -2.397 -0.9998 3188354 PK04_102057 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCO)C(=O)N(Cc4cccc(c4)N5C(=O)c6cccc7cccc5c67)c8ccccc83 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 C18 compound treatment 145520.0 -370000.0 -1.85 110680.0 -385000.0 -1.81 -2.5871 -0.9999 3069396 PK04_102058 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCO)C(=O)N(CC=C)c4ccc(NC(=O)[C@H](C)O)cc43 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 C19 compound treatment 120560.0 -395000.0 -1.97 84010.0 -411000.0 -1.94 -2.7639 -1.0 3188355 PK04_102059 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCO)C(=O)N(Cc4cccc(c4)N5C(=O)COc6ccccc56)c7ccccc73 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 C20 compound treatment 99560.0 -416000.0 -2.08 107960.0 -388000.0 -1.82 -2.7585 -0.9979 3188356 PK04_102060 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCO)C(=O)N(Cc4cccc(c4)N5C(=O)c6ccccc6Oc7ccccc57)c8ccccc83 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 C21 compound treatment 167590.0 -348000.0 -1.74 162020.0 -333000.0 -1.57 -2.3384 -0.9987 3069397 PK04_102061 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCn4cc(CCO)nn4)C(=O)N(Cc5ccc(cc5)N6CCOC6=O)c7ccccc73 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 C22 compound treatment 255150.0 -261000.0 -1.3 156490.0 -339000.0 -1.59 -2.0476 -0.9949 3188357 PK04_102062 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCO)C(=O)N(Cc4ccccc4)c5ccc(cc53)N6C(=O)COc7ccccc67 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 C23 compound treatment 162140.0 -354000.0 -1.77 144160.0 -351000.0 -1.65 -2.417 -0.9995 3188358 PK04_102063 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCO)C(=O)N(Cc4ccc(cc4)N5C(=O)c6cccc7cccc5c67)c8ccccc83 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 C24 compound treatment 255630.0 -260000.0 -1.3 150720.0 -345000.0 -1.62 -2.0651 -0.9939 3069398 PK04_102064 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCn4cc(CCO)nn4)C(=O)N(Cc5ccc(cc5)N6C(=O)c7cccc8cccc6c78)c9ccccc93 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 D01 compound treatment 451560.0 -64100.0 -0.32 403410.0 -92100.0 -0.43 -0.5327 -0.9889 3188359 PK04_102065 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CC(=O)N(CCO)Cc4ccccc4)C(=O)N(Cc5cccc(c5)N6CCC6=O)c7ccccc73 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 D02 compound treatment 293230.0 -222000.0 -1.11 408600.0 -86900.0 -0.41 -1.0746 -0.9078 3069399 PK04_102066 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CC(=O)N4Cc5ccccc5C[C@H]4CO)C(=O)N(Cc6ccc(I)cc6)c7ccccc73 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 D03 compound treatment 316600.0 -199000.0 -0.99 360320.0 -135000.0 -0.64 -1.1526 -0.9767 3188360 PK04_102067 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CC(=O)N4Cc5ccccc5C[C@H]4CO)C(=O)N(Cc6ccc(cc6)N7CCC7=O)c8ccccc83 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 D04 compound treatment 479040.0 -36600.0 -0.18 203060.0 -292000.0 -1.38 -1.102 -0.7941 3188361 PK04_102068 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CC(=O)N4CCC[C@H]4CO)C(=O)N(Cc5cccc(c5)N6CCOC6=O)c7ccccc73 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 D05 compound treatment 231890.0 -284000.0 -1.42 212120.0 -283000.0 -1.33 -1.9447 -0.9995 3069400 PK04_102069 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CC(=O)N(CCO)Cc4ccccc4)C(=O)N(Cc5cccc(c5)N6CCC6=O)c7ccccc73 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 D06 compound treatment 470090.0 -45600.0 -0.23 430850.0 -64600.0 -0.3 -0.3759 -0.9898 3188362 PK04_102070 C[C@H](C=C)[C@H](O)c1ccc(O)c2ccccc12 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 D07 compound treatment 267680.0 -248000.0 -1.24 245310.0 -250000.0 -1.18 -1.7079 -0.9997 3188363 PK04_102071 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCn4cc(nn4)[C@H](O)c5ccccc5)C(=O)N(Cc6ccc(cc6)N7CCC7=O)c8ccccc83 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 D08 compound treatment 464040.0 -51600.0 -0.26 550720.0 55200.0 0.26 0.0014 0.0038 3069401 PK04_102072 CO[C@H](C=C)[C@H](O)c1ccc(OC)c(O)c1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 D09 compound treatment 261510.0 -254000.0 -1.27 274460.0 -221000.0 -1.04 -1.6327 -0.9951 3188364 PK04_102073 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CC(=O)N(CCO)Cc4ccccc4)C(=O)N(Cc5cccc(c5)N6CCOC6=O)c7ccccc73 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 D10 compound treatment 393730.0 -122000.0 -0.61 246640.0 -249000.0 -1.17 -1.2583 -0.9536 3069402 PK04_102074 CO[C@H](C=C)[C@H](OC(=O)Nc1ccc(OC)cc1)c2ccc(O)c(F)c2 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 D11 mock treatment 500800.0 -14900.0 -0.07 302930.0 -193000.0 -0.91 -0.6929 -0.7625 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 D12 mock treatment 536180.0 20500.0 0.1 519250.0 23800.0 0.11 0.1515 0.9991 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 D13 compound treatment 316870.0 -199000.0 -0.99 228170.0 -267000.0 -1.26 -1.5912 -0.9932 3069403 PK04_102075 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCn4cc(CCO)nn4)C(=O)N(CC=C)c5ccc(cc53)N6CCC6=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 D14 compound treatment 264090.0 -252000.0 -1.26 203150.0 -292000.0 -1.38 -1.8608 -0.999 3188365 PK04_102076 CSc1ccc(NC(=O)O[C@@H]([C@@H](C)C=C)c2ccc(O)c3ccccc23)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 D15 mock treatment 560980.0 45300.0 0.23 254050.0 -241000.0 -1.14 -0.643 -0.5553 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 D16 mock treatment 527150.0 11500.0 0.06 243720.0 -252000.0 -1.18 -0.7968 -0.6721 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 D17 compound treatment 329320.0 -186000.0 -0.93 357210.0 -138000.0 -0.65 -1.118 -0.9847 3188366 PK04_102077 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CC(=O)N4CCC[C@H]4CO)C(=O)N(Cc5ccc(cc5)N6CCC6=O)c7ccccc73 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 D18 compound treatment 501280.0 -14400.0 -0.07 215730.0 -280000.0 -1.32 -0.9813 -0.7446 3069404 PK04_102078 C[C@@H](C=C)[C@@H](O)c1ccc(OCCO)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 D19 compound treatment 242370.0 -273000.0 -1.36 210510.0 -285000.0 -1.34 -1.913 -1.0 3188367 PK04_102079 COc1ccc(cc1)C(=O)Nc2cccc(CN3C(=O)[C@]4(O[C@H](CC(=O)N5CCC[C@H]5CO)[C@H]([C@@H]4C)[Si](C)(C)c6ccc(OC)cc6)c7ccccc37)c2 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 D20 compound treatment 102660.0 -413000.0 -2.06 152640.0 -343000.0 -1.61 -2.5989 -0.9926 3069405 PK04_102080 COc1ccc(NC(=O)O[C@H]([C@H](C)C=C)c2ccc(O)c3ccccc23)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 D21 compound treatment 182900.0 -333000.0 -1.66 202080.0 -293000.0 -1.38 -2.1511 -0.9957 3188368 PK04_102081 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CC(=O)N4Cc5ccccc5C[C@H]4CO)C(=O)N(Cc6ccc(cc6)N7CCOC7=O)c8ccccc83 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 D22 compound treatment 423680.0 -92000.0 -0.46 405640.0 -89900.0 -0.42 -0.6237 -0.9991 3069440 PK04_102082 COc1ccc(NC(=O)O[C@@H]([C@@H](C)C=C)c2ccc(OCCO)cc2)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 D23 compound treatment 302240.0 -213000.0 -1.07 174610.0 -321000.0 -1.51 -1.821 -0.9855 3188485 PK04_102083 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CC(=O)N4Cc5ccccc5C[C@H]4CO)C(=O)N(Cc6cccc(c6)N7CCOC7=O)c8ccccc83 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 D24 compound treatment 344050.0 -172000.0 -0.86 163170.0 -332000.0 -1.56 -1.7114 -0.96 3069441 PK04_102084 O[C@H](CC=C)c1ccc(O)c(F)c1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 E01 mock treatment 620220.0 105000.0 0.52 545920.0 50400.0 0.24 0.537 0.9362 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 E02 mock treatment 624920.0 109000.0 0.55 606740.0 111000.0 0.52 0.7559 0.9998 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 E03 compound treatment 285780.0 -230000.0 -1.15 477360.0 -18100.0 -0.09 -0.8722 -0.7575 3069442 PK04_102085 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCn4cc(nn4)[C@H](O)c5ccccc5)C(=O)N(c6ccccc63)c7ccccc7 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 E04 compound treatment 113070.0 -403000.0 -2.01 133290.0 -362000.0 -1.7 -2.6265 -0.9966 3188486 PK04_102086 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCO)C(=O)N(CC=C)c4ccc(cc43)N5CCCCC5=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 E05 compound treatment 130760.0 -385000.0 -1.92 175040.0 -320000.0 -1.51 -2.4252 -0.9928 3188487 PK04_102087 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CC(=O)N4Cc5ccccc5C[C@H]4CO)C(=O)N(c6ccccc63)c7ccccc7 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 E06 compound treatment 271840.0 -244000.0 -1.22 409450.0 -86000.0 -0.4 -1.1473 -0.894 3069443 PK04_102088 COc1ccc(cc1)C(=O)Nc2ccc3N(CC=C)C(=O)[C@@]4(O[C@@H](CCn5cc(nn5)[C@H](O)c6ccccc6)[C@@H]([C@H]4C)[Si](C)(C)c7ccc(OC)cc7)c3c2 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 E07 compound treatment 226320.0 -289000.0 -1.45 304920.0 -191000.0 -0.9 -1.6557 -0.9736 3188488 PK04_102089 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCn4cc(CCO)nn4)C(=O)N(c5ccccc53)c6ccccc6 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 E08 compound treatment 163370.0 -352000.0 -1.76 139200.0 -356000.0 -1.68 -2.4292 -0.9997 3188489 PK04_102090 COc1ccc(cc1)C(=O)Nc2cccc(CN3C(=O)[C@]4(O[C@H](CCn5cc(CCO)nn5)[C@H]([C@@H]4C)[Si](C)(C)c6ccc(OC)cc6)c7ccccc37)c2 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 E09 mock treatment 376030.0 -140000.0 -0.7 604360.0 109000.0 0.51 -0.131 -0.1515 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 E10 mock treatment 529280.0 13600.0 0.07 507760.0 12300.0 0.06 0.0889 0.9967 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 E11 compound treatment 326820.0 -189000.0 -0.94 199420.0 -296000.0 -1.39 -1.6517 -0.982 3069444 PK04_102091 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CC(=O)N(CCO)Cc4ccccc4)C(=O)N(C)c5ccccc53 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 E12 compound treatment 170990.0 -345000.0 -1.72 243210.0 -252000.0 -1.19 -2.0564 -0.9835 3188490 PK04_102092 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCO)C(=O)N(Cc4ccc(cc4)N(C=O)c5ccccc5)c6ccccc63 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 E13 compound treatment 342360.0 -173000.0 -0.87 430620.0 -64900.0 -0.31 -0.8278 -0.902 3069445 PK04_102093 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CC(=O)N(CCO)Cc4ccccc4)C(=O)N(C)c5c3cc(C)cc5Br 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 E14 compound treatment 336410.0 -179000.0 -0.9 257040.0 -238000.0 -1.12 -1.4261 -0.9938 3188491 PK04_102094 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCO)C(=O)N(Cc4ccc(cc4)N(C=O)c5ccccc5)c6ccccc63 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 E15 compound treatment 200440.0 -315000.0 -1.57 319250.0 -176000.0 -0.83 -1.6994 -0.9551 3188492 PK04_102095 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CC(=O)N4Cc5ccccc5C[C@H]4CO)C(=O)N(C)c6c3cc(C)cc6Br 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 E16 compound treatment 296050.0 -220000.0 -1.1 292980.0 -203000.0 -0.95 -1.4491 -0.9975 3069446 PK04_102096 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCn4cc(nn4)[C@H](O)c5ccccc5)C(=O)N(Cc6cccc(c6)N7C(=O)c8cccc9cccc7c89)c%10ccccc%103 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 E17 mock treatment 406140.0 -110000.0 -0.55 354880.0 -141000.0 -0.66 -0.8545 -0.9956 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 E18 mock treatment 408880.0 -107000.0 -0.53 291040.0 -204000.0 -0.96 -1.0571 -0.9613 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 E19 compound treatment 151700.0 -364000.0 -1.82 134760.0 -361000.0 -1.7 -2.4852 -0.9994 3188493 PK04_102097 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCO)C(=O)N(Cc4cccc(c4)N5CCCCC5=O)c6ccccc63 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 E20 compound treatment 219810.0 -296000.0 -1.48 344160.0 -151000.0 -0.71 -1.5482 -0.9439 3188494 PK04_102098 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCn4cc(nn4)[C@H](O)c5ccccc5)C(=O)N(Cc6ccc(cc6)N7CCOC7=O)c8ccccc83 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 E21 compound treatment 180610.0 -335000.0 -1.67 228520.0 -267000.0 -1.26 -2.0712 -0.99 3069448 PK04_102099 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCO)C(=O)N(Cc4ccc(cc4)N5CCOC5=O)c6ccccc63 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 E22 compound treatment 161380.0 -354000.0 -1.77 140440.0 -355000.0 -1.67 -2.4321 -0.9996 3188495 PK04_102100 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCO)C(=O)N(CC=C)c4ccc(cc43)N5CCOC5=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 E23 compound treatment 119060.0 -397000.0 -1.98 125340.0 -370000.0 -1.74 -2.6318 -0.9979 3069450 PK04_102101 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCO)C(=O)N(Cc4ccc(cc4)N5CCOC5=O)c6ccccc63 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 E24 compound treatment 127600.0 -388000.0 -1.94 165280.0 -330000.0 -1.55 -2.4688 -0.994 3188496 PK04_102102 COc1ccc(cc1)C(=O)Nc2ccc3N(CC=C)C(=O)[C@]4(O[C@H](CCn5cc(CCO)nn5)[C@H]([C@@H]4C)[Si](C)(C)c6ccc(OC)cc6)c3c2 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 F01 mock treatment 580160.0 64500.0 0.32 586080.0 90600.0 0.43 0.5291 0.9905 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 F02 mock treatment 656490.0 141000.0 0.7 602810.0 107000.0 0.5 0.8543 0.9868 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 F03 compound treatment 219360.0 -296000.0 -1.48 486480.0 -9010.0 -0.04 -1.0764 -0.7271 3188497 PK04_102103 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCn4cc(nn4)[C@H](O)c5ccccc5)C(=O)N(CC=C)c6ccc(cc63)N7CCC7=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 F04 compound treatment 127470.0 -388000.0 -1.94 344660.0 -151000.0 -0.71 -1.8726 -0.907 3069264 PK04_102104 C[C@H](C=C)[C@@H](O)c1ccc(O)c2ccccc12 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 F05 compound treatment 173290.0 -342000.0 -1.71 235840.0 -260000.0 -1.22 -2.0727 -0.9864 3069265 PK04_102105 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CC(=O)N4CCC[C@H]4CO)C(=O)N(Cc5ccc(cc5)N6CCOC6=O)c7ccccc73 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 F06 compound treatment 380700.0 -135000.0 -0.67 297800.0 -198000.0 -0.93 -1.1342 -0.9875 3188498 PK04_102106 CSc1ccc(NC(=O)O[C@H]([C@@H](C)C=C)c2ccc(O)c3ccccc23)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 F07 compound treatment 219520.0 -296000.0 -1.48 139080.0 -356000.0 -1.68 -2.2313 -0.9981 3188499 PK04_102107 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCO)C(=O)N(Cc4ccc(cc4)N5CCC5=O)c6ccccc63 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 F08 compound treatment 417040.0 -98600.0 -0.49 485610.0 -9880.0 -0.05 -0.3812 -0.7704 3069441 PK04_102108 O[C@H](CC=C)c1ccc(O)c(F)c1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 F09 mock treatment 502660.0 -13000.0 -0.06 515800.0 20300.0 0.1 0.0216 0.1872 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 F10 mock treatment 576000.0 60300.0 0.3 557480.0 62000.0 0.29 0.4193 0.9999 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 F11 compound treatment 293830.0 -222000.0 -1.11 224010.0 -271000.0 -1.28 -1.6864 -0.9975 3188500 PK04_102109 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CC(=O)N(CCO)Cc4ccccc4)C(=O)N(Cc5ccc(cc5)N6C(=O)c7cccc8cccc6c78)c9ccccc93 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 F12 compound treatment 514730.0 -933.0 0.0 448320.0 -47200.0 -0.22 -0.1602 -0.7218 3069270 PK04_102110 CO[C@@H](C=C)[C@@H](O)c1ccc(OCCO)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 F13 compound treatment 291520.0 -224000.0 -1.12 239360.0 -256000.0 -1.2 -1.6435 -0.9993 3188501 PK04_102111 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCn4cc(CCO)nn4)C(=O)N(C)c5c3cc(C)cc5Br 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 F14 compound treatment 552990.0 37300.0 0.19 503940.0 8450.0 0.04 0.1599 0.839 3188502 PK04_102112 CSc1ccc(NC(=O)O[C@H]([C@@H](C)C=C)c2ccc(OCCO)cc2)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 F15 compound treatment 481160.0 -34500.0 -0.17 197040.0 -298000.0 -1.4 -1.1145 -0.788 3188623 PK04_102113 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CC(=O)N4CCC[C@H]4CO)C(=O)N(Cc5cccc(c5)N6C(=O)c7cccc8cccc6c78)c9ccccc93 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 F16 compound treatment 491700.0 -24000.0 -0.12 391680.0 -104000.0 -0.49 -0.4299 -0.8551 3069312 PK04_102114 CO[C@H](C=C)[C@H](OC(=O)Nc1ccc(SC)cc1)c2ccc(O)c(F)c2 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 F17 mock treatment 592860.0 77200.0 0.39 400080.0 -95400.0 -0.45 -0.0447 -0.0756 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 F18 mock treatment 489880.0 -25800.0 -0.13 586080.0 90600.0 0.43 0.2102 0.4723 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 F19 compound treatment 235200.0 -280000.0 -1.4 176830.0 -319000.0 -1.5 -2.0504 -0.9994 3188624 PK04_102115 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CC(=O)N4Cc5ccccc5C[C@H]4CO)C(=O)N(Cc6cccc(c6)N7CCC7=O)c8ccccc83 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 F20 compound treatment 507110.0 -8550.0 -0.04 183110.0 -312000.0 -1.47 -1.0692 -0.7274 3069314 PK04_102116 CO[C@H](C=C)[C@H](O)c1ccc(O)c(F)c1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 F21 compound treatment 259800.0 -256000.0 -1.28 390590.0 -105000.0 -0.49 -1.2525 -0.9143 3069316 PK04_102117 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCn4cc(nn4)[C@H](O)c5ccccc5)C(=O)N(CC=C)c6ccc(cc63)N7CCC7=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 F22 compound treatment 269960.0 -246000.0 -1.23 302590.0 -193000.0 -0.91 -1.5093 -0.989 3188625 PK04_102118 O[C@@H](CC=C)c1ccc(O)c2ccccc12 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 F23 compound treatment 254300.0 -261000.0 -1.31 155870.0 -340000.0 -1.6 -2.0526 -0.995 3188626 PK04_102119 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CC(=O)N(CCO)Cc4ccccc4)C(=O)N(Cc5ccc(cc5)N6CCOC6=O)c7ccccc73 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 F24 compound treatment 295840.0 -220000.0 -1.1 481300.0 -14200.0 -0.07 -0.8235 -0.7487 3069318 PK04_102120 CO[C@@H](C=C)[C@@H](OC(=O)Nc1ccc(OC)cc1)c2ccc(OC)c(O)c2 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 G01 compound treatment 392050.0 -124000.0 -0.62 300450.0 -195000.0 -0.92 -1.0853 -0.9814 3069320 PK04_102121 COc1ccc(cc1)[Si](C)(C)[C@H](CCn2cc(CCO)nn2)/C=C/C 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 G02 compound treatment 317230.0 -198000.0 -0.99 429520.0 -66000.0 -0.31 -0.9202 -0.8861 3188627 PK04_102122 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCn4cc(CCO)nn4)C(=O)N(CC=C)c5ccc(cc53)N6CCOC6=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 G03 mock treatment 632600.0 117000.0 0.58 608530.0 113000.0 0.53 0.7889 0.9989 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 G04 mock treatment 598920.0 83300.0 0.42 583840.0 88300.0 0.42 0.5879 1.0 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 G05 compound treatment 187070.0 -329000.0 -1.64 180830.0 -315000.0 -1.48 -2.207 -0.9987 3069321 PK04_102123 COc1ccc(cc1)[Si](C)(C)[C@H](CC(=O)N2Cc3ccccc3C[C@H]2CO)/C=C/C 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 G06 compound treatment 103070.0 -413000.0 -2.06 161160.0 -334000.0 -1.57 -2.5691 -0.9911 3188628 PK04_102124 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCn4cc(CCO)nn4)C(=O)N(CC=C)c5ccc(cc53)N6C(=O)c7cccc8cccc6c78 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 G07 compound treatment 175840.0 -340000.0 -1.7 167080.0 -328000.0 -1.54 -2.2924 -0.9989 3069362 PK04_102125 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCO)C(=O)N(C)c4ccccc43 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 G08 compound treatment 214690.0 -301000.0 -1.5 336160.0 -159000.0 -0.75 -1.5929 -0.9483 3188629 PK04_102126 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCO)C(=O)N(Cc4ccccc4)c5ccc(cc53)N6CCOC6=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 G09 compound treatment 212700.0 -303000.0 -1.51 154940.0 -341000.0 -1.6 -2.2026 -0.9996 3188630 PK04_102127 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCO)C(=O)N(CC=C)c4ccc(I)cc43 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 G10 compound treatment 167040.0 -349000.0 -1.74 443750.0 -51700.0 -0.24 -1.4033 -0.7982 3188631 PK04_102128 COc1ccc(cc1)C(=O)Nc2cccc(CN3C(=O)[C@@]4(O[C@@H](CCn5cc(nn5)[C@H](O)c6ccccc6)[C@@H]([C@H]4C)[Si](C)(C)c7ccc(OC)cc7)c8ccccc38)c2 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 G11 compound treatment 138040.0 -378000.0 -1.89 132800.0 -363000.0 -1.71 -2.5399 -0.9987 3069365 PK04_102129 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCO)C(=O)N(C)c4c3cc(C)cc4Br 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 G12 compound treatment 451890.0 -63800.0 -0.32 214810.0 -281000.0 -1.32 -1.1588 -0.8532 3188632 PK04_102130 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCn4cc(nn4)[C@H](O)c5ccccc5)C(=O)N(Cc6cccc(c6)N7C(=O)c8cccc9cccc7c89)c%10ccccc%103 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 G13 compound treatment 139520.0 -376000.0 -1.88 129400.0 -366000.0 -1.72 -2.546 -0.9991 3069368 PK04_102131 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCO)C(=O)N(CC=C)c4ccccc43 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 G14 compound treatment 153780.0 -362000.0 -1.81 111600.0 -384000.0 -1.81 -2.5549 -1.0 3069370 PK04_102132 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCO)C(=O)N(Cc4cccc(NC(=O)C)c4)c5ccccc53 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 G15 compound treatment 365920.0 -150000.0 -0.75 311230.0 -184000.0 -0.87 -1.1417 -0.9973 3188633 PK04_102133 COc1ccc(cc1)[Si](C)(C)[C@@H](CC(=O)N2Cc3ccccc3C[C@H]2CO)/C=C/C 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 G16 compound treatment 219680.0 -296000.0 -1.48 150200.0 -345000.0 -1.62 -2.1937 -0.9989 3188634 PK04_102134 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCO)C(=O)N(Cc4ccc(cc4)N5C(=O)COc6ccccc56)c7ccccc73 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 G17 compound treatment 188650.0 -327000.0 -1.63 77510.0 -418000.0 -1.97 -2.5451 -0.9958 3188635 PK04_102135 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCO)C(=O)N(Cc4cccc(NC(=O)[C@H](C)O)c4)c5ccccc53 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 G18 compound treatment 430560.0 -85100.0 -0.43 246720.0 -249000.0 -1.17 -1.128 -0.906 3069408 PK04_102136 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCn4cc(CCO)nn4)C(=O)N(CC=C)c5ccc(cc53)N6CCOC6=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 G19 mock treatment 548090.0 32400.0 0.16 248480.0 -247000.0 -1.16 -0.707 -0.6027 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 G20 mock treatment 527920.0 12300.0 0.06 372730.0 -123000.0 -0.58 -0.365 -0.6286 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 G21 compound treatment 207110.0 -309000.0 -1.54 149840.0 -346000.0 -1.63 -2.2393 -0.9996 3188636 PK04_102137 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCO)C(=O)N(CC=C)c4ccc(cc43)N(C=O)c5ccccc5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 G22 compound treatment 205940.0 -310000.0 -1.55 106400.0 -389000.0 -1.83 -2.3879 -0.9965 3188637 PK04_102138 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCn4cc(CCO)nn4)C(=O)N(Cc5cccc(c5)N6CCOC6=O)c7ccccc73 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 G23 compound treatment 158040.0 -358000.0 -1.79 184990.0 -311000.0 -1.46 -2.2957 -0.995 3069412 PK04_102139 COc1ccc(cc1)C(=O)Nc2ccc3N(CC=C)C(=O)[C@@]4(O[C@@H](CCn5cc(CCO)nn5)[C@@H]([C@H]4C)[Si](C)(C)c6ccc(OC)cc6)c3c2 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 G24 compound treatment 147720.0 -368000.0 -1.84 187060.0 -308000.0 -1.45 -2.3253 -0.9931 3188638 PK04_102140 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCO)C(=O)N(Cc4ccc(cc4)N5CCCCC5=O)c6ccccc63 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 H01 compound treatment 241280.0 -274000.0 -1.37 203390.0 -292000.0 -1.37 -1.9406 -1.0 3188639 PK04_102141 COc1ccc(cc1)C(=O)Nc2ccc(CN3C(=O)[C@@]4(O[C@@H](CC(=O)N(CCO)Cc5ccccc5)[C@@H]([C@H]4C)[Si](C)(C)c6ccc(OC)cc6)c7ccccc37)cc2 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 H02 compound treatment 529310.0 13600.0 0.07 516920.0 21400.0 0.1 0.1195 0.9819 3069414 PK04_102142 CSc1ccc(NC(=O)O[C@H]([C@H](C)C=C)c2ccc(OCCO)cc2)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 H03 mock treatment 611440.0 95800.0 0.48 580820.0 85300.0 0.4 0.6221 0.9962 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 H04 mock treatment 556060.0 40400.0 0.2 335360.0 -160000.0 -0.75 -0.3899 -0.5001 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 H05 compound treatment 463700.0 -52000.0 -0.26 265640.0 -230000.0 -1.08 -0.948 -0.8526 3188755 PK04_102143 COc1ccc(cc1)C(=O)Nc2ccc(CN3C(=O)[C@@]4(O[C@@H](CC(=O)N5Cc6ccccc6C[C@H]5CO)[C@@H]([C@H]4C)[Si](C)(C)c7ccc(OC)cc7)c8ccccc38)cc2 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 H06 compound treatment 195580.0 -320000.0 -1.6 510460.0 15000.0 0.07 -1.0806 -0.6753 3188362 PK04_102144 C[C@H](C=C)[C@H](O)c1ccc(O)c2ccccc12 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 H07 compound treatment 188320.0 -327000.0 -1.63 278010.0 -217000.0 -1.02 -1.8794 -0.9745 3188756 PK04_102145 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CC(=O)N4Cc5ccccc5C[C@H]4CO)C(=O)N(Cc6cccc(c6)N7CCCCC7=O)c8ccccc83 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 H08 compound treatment 266040.0 -250000.0 -1.25 278050.0 -217000.0 -1.02 -1.6048 -0.9952 3069452 PK04_102146 CSc1ccc(NC(=O)O[C@@H](CC=C)c2ccc(O)c(F)c2)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 H09 compound treatment 296850.0 -219000.0 -1.09 223120.0 -272000.0 -1.28 -1.6787 -0.9969 3188757 PK04_102147 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CC(=O)N4Cc5ccccc5C[C@H]4CO)C(=O)N(Cc6ccc(cc6)N7CCOC7=O)c8ccccc83 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 H10 compound treatment 200590.0 -315000.0 -1.57 143320.0 -352000.0 -1.66 -2.284 -0.9997 3069454 PK04_102148 COc1ccc(NC(=O)O[C@@H]([C@@H](C)C=C)c2ccc(O)c3ccccc23)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 H11 compound treatment 141080.0 -375000.0 -1.87 97650.0 -398000.0 -1.87 -2.6461 -1.0 3188758 PK04_102149 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCn4cc(CCO)nn4)C(=O)N(Cc5cccc(c5)N6CCOC6=O)c7ccccc73 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 H12 compound treatment 164800.0 -351000.0 -1.75 146460.0 -349000.0 -1.64 -2.4 -0.9995 3069456 PK04_102150 COc1ccc(NC(=O)O[C@H](CC=C)c2ccc(O)c(F)c2)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 H13 compound treatment 225180.0 -290000.0 -1.45 274240.0 -221000.0 -1.04 -1.7618 -0.9867 3188759 PK04_102151 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CC(=O)N4CCC[C@H]4CO)C(=O)N(Cc5cccc(c5)N6C(=O)COc7ccccc67)c8ccccc83 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 H14 compound treatment 159850.0 -356000.0 -1.78 94880.0 -401000.0 -1.88 -2.589 -0.9996 3069458 PK04_102152 CSc1ccc(NC(=O)O[C@@H](CC=C)c2ccc(O)c3ccccc23)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 H15 compound treatment 254280.0 -261000.0 -1.31 221960.0 -274000.0 -1.29 -1.8329 -1.0 3188760 PK04_102153 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCn4cc(CCO)nn4)C(=O)N(CC=C)c5ccc(cc53)N6CCC6=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 H16 compound treatment 571050.0 55400.0 0.28 284680.0 -211000.0 -0.99 -0.5055 -0.4911 3069460 PK04_102154 COc1ccc(NC(=O)O[C@H](CC=C)c2ccc(OCCO)cc2)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 H17 compound treatment 285600.0 -230000.0 -1.15 267840.0 -228000.0 -1.07 -1.5697 -0.9994 3188761 PK04_102155 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCO)C(=O)N(Cc4ccccc4)c5ccc(cc53)N6CCC6=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 H18 compound treatment 212120.0 -304000.0 -1.52 50260.0 -445000.0 -2.09 -2.5528 -0.9874 3069461 PK04_102156 COc1ccc(NC(=O)O[C@H](CC=C)c2ccc(O)c3ccccc23)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 H19 mock treatment 423920.0 -91700.0 -0.46 594170.0 98700.0 0.46 0.0042 0.0064 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 H20 mock treatment 459570.0 -56100.0 -0.28 504090.0 8600.0 0.04 -0.1695 -0.5988 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 H21 compound treatment 325480.0 -190000.0 -0.95 272000.0 -223000.0 -1.05 -1.415 -0.9987 3188762 PK04_102157 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CC(=O)N4CCC[C@H]4CO)C(=O)N(Cc5cccc(c5)N6CCCCC6=O)c7ccccc73 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 H22 compound treatment 386420.0 -129000.0 -0.65 218310.0 -277000.0 -1.3 -1.3783 -0.9474 3069504 PK04_102158 O[C@H](CC=C)c1ccc(O)c2ccccc12 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 H23 compound treatment 239040.0 -277000.0 -1.38 216510.0 -279000.0 -1.31 -1.9048 -0.9997 3188763 PK04_102159 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CC(=O)N(CCO)Cc4ccccc4)C(=O)N(Cc5ccc(cc5)N6CCC6=O)c7ccccc73 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 H24 compound treatment 415200.0 -100000.0 -0.5 578050.0 82600.0 0.39 -0.0802 -0.1264 3069401 PK04_102160 CO[C@H](C=C)[C@H](O)c1ccc(OC)c(O)c1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 I01 compound treatment 283300.0 -232000.0 -1.16 378110.0 -117000.0 -0.55 -1.211 -0.9423 3069507 PK04_102161 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CC(=O)N(CCO)Cc4ccccc4)C(=O)N(C)c5ccccc53 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 I02 compound treatment 354020.0 -162000.0 -0.81 177990.0 -318000.0 -1.49 -1.6269 -0.9583 3188764 PK04_102162 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCO)C(=O)N(Cc4ccccc4)c5ccc(cc53)N6C(=O)c7ccccc7Oc8ccccc68 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 I03 compound treatment 425920.0 -89700.0 -0.45 403680.0 -91800.0 -0.43 -0.6223 -0.9998 3188765 PK04_102163 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCn4cc(CCO)nn4)C(=O)N(C)c5ccccc53 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 I04 compound treatment 94310.0 -421000.0 -2.1 125160.0 -370000.0 -1.74 -2.7198 -0.9956 3069594 PK04_102164 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCO)C(=O)N(Cc4cccc(NC(=O)C)c4)c5ccccc53 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 I05 mock treatment 205200.0 -310000.0 -1.55 574670.0 79200.0 0.37 -0.8331 -0.5224 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 I06 mock treatment 539870.0 24200.0 0.12 576520.0 81000.0 0.38 0.355 0.8878 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 I07 compound treatment 479680.0 -36000.0 -0.18 262830.0 -233000.0 -1.09 -0.9009 -0.8123 3188766 PK04_102165 COc1ccc(cc1)[Si](C)(C)[C@@H](CCn2cc(nn2)[C@H](O)c3ccccc3)/C=C/C 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 I08 compound treatment 500530.0 -15100.0 -0.08 187360.0 -308000.0 -1.45 -1.0783 -0.743 3188767 PK04_102166 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCn4cc(nn4)[C@H](O)c5ccccc5)C(=O)N(Cc6cccc(c6)N7CCOC7=O)c8ccccc83 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 I09 compound treatment 565040.0 49400.0 0.25 319740.0 -176000.0 -0.83 -0.4102 -0.4755 3069598 PK04_102167 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CC(=O)N4CCC[C@H]4CO)C(=O)N(C)c5ccccc53 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 I10 compound treatment 204710.0 -311000.0 -1.55 247840.0 -248000.0 -1.16 -1.9219 -0.99 3188768 PK04_102168 COc1ccc(cc1)C(=O)Nc2ccc(CN3C(=O)[C@@]4(O[C@@H](CCn5cc(CCO)nn5)[C@@H]([C@H]4C)[Si](C)(C)c6ccc(OC)cc6)c7ccccc37)cc2 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 I11 compound treatment 116640.0 -399000.0 -1.99 102750.0 -393000.0 -1.85 -2.7155 -0.9993 3188769 PK04_102169 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCO)C(=O)N(CC=C)c4ccc(I)cc43 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 I12 compound treatment 132960.0 -383000.0 -1.91 110180.0 -385000.0 -1.81 -2.6331 -0.9996 3069636 PK04_102170 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCO)C(=O)N(Cc4cccc(c4)N5CCOC5=O)c6ccccc63 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 I13 compound treatment 135200.0 -380000.0 -1.9 177790.0 -318000.0 -1.49 -2.4003 -0.9929 3188770 PK04_102171 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CC(=O)N(CCO)Cc4ccccc4)C(=O)N(c5ccccc53)c6ccccc6 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 I14 compound treatment 147310.0 -368000.0 -1.84 111250.0 -384000.0 -1.81 -2.5789 -1.0 3188771 PK04_102172 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCO)C(=O)N(Cc4ccc(cc4)N5C(=O)c6ccccc6Oc7ccccc57)c8ccccc83 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 I15 compound treatment 459460.0 -56200.0 -0.28 365570.0 -130000.0 -0.61 -0.6306 -0.9377 3069640 PK04_102173 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCn4cc(CCO)nn4)C(=O)N(C)c5ccccc53 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 I16 compound treatment 171240.0 -344000.0 -1.72 132160.0 -363000.0 -1.71 -2.4248 -1.0 3188888 PK04_102174 COc1ccc(cc1)C(=O)Nc2ccc3N(CC=C)C(=O)[C@]4(O[C@H](CCO)[C@H]([C@@H]4C)[Si](C)(C)c5ccc(OC)cc5)c3c2 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 I17 compound treatment 184560.0 -331000.0 -1.65 246320.0 -249000.0 -1.17 -1.9981 -0.9858 3069645 PK04_102175 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCO)C(=O)N(CC=C)c4ccc(NC(=O)C)cc43 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 I18 compound treatment 267680.0 -248000.0 -1.24 581000.0 85500.0 0.4 -0.5914 -0.4541 3188889 PK04_102176 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCn4cc(nn4)[C@H](O)c5ccccc5)C(=O)N(CC=C)c6ccc(cc63)N7C(=O)c8cccc9cccc7c89 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 I19 compound treatment 176930.0 -339000.0 -1.69 190830.0 -305000.0 -1.43 -2.2096 -0.9966 3069647 PK04_102177 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCO)C(=O)N(Cc4cccc(c4)N5C(=O)c6cccc7cccc5c67)c8ccccc83 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 I20 compound treatment 386020.0 -130000.0 -0.65 227720.0 -268000.0 -1.26 -1.3485 -0.9522 3188890 PK04_102178 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCO)C(=O)N(Cc4ccc(cc4)N5C(=O)c6ccccc6Oc7ccccc57)c8ccccc83 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 I21 mock treatment 558040.0 42400.0 0.21 426040.0 -69500.0 -0.33 -0.0813 -0.209 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 I22 mock treatment 518950.0 3290.0 0.02 556520.0 61000.0 0.29 0.2146 0.7463 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 I23 compound treatment 141850.0 -374000.0 -1.87 161280.0 -334000.0 -1.57 -2.4318 -0.9963 3188891 PK04_102179 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCO)C(=O)N(CC=C)c4ccc(cc43)N5C(=O)c6cccc7cccc5c67 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 I24 compound treatment 152720.0 -363000.0 -1.81 189460.0 -306000.0 -1.44 -2.2996 -0.9935 3069706 PK04_102180 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCO)C(=O)N(CC=C)c4ccc(cc43)N(C=O)c5ccccc5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 J01 compound treatment 424540.0 -91100.0 -0.46 468640.0 -26900.0 -0.13 -0.4111 -0.8704 3188892 PK04_102181 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CC(=O)N(CCO)Cc4ccccc4)C(=O)N(Cc5ccc(cc5)N6CCC6=O)c7ccccc73 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 J02 compound treatment 470450.0 -45200.0 -0.23 499960.0 4470.0 0.02 -0.1448 -0.6385 3069707 PK04_102182 CSc1ccc(NC(=O)O[C@@H](CC=C)c2ccc(OCCO)cc2)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 J03 compound treatment 181120.0 -335000.0 -1.67 334760.0 -161000.0 -0.76 -1.7161 -0.9357 3188893 PK04_102183 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CC(=O)N(CCO)Cc4ccccc4)C(=O)N(Cc5cccc(c5)N6CCCCC6=O)c7ccccc73 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 J04 compound treatment 470830.0 -44800.0 -0.22 583380.0 87900.0 0.41 0.134 0.285 3069711 PK04_102184 CO[C@H](C=C)[C@H](OC(=O)Nc1ccc(OC)cc1)c2ccc(OC)c(O)c2 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 J05 mock treatment 542200.0 26500.0 0.13 577480.0 82000.0 0.39 0.3664 0.8985 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 J06 mock treatment 253040.0 -263000.0 -1.31 583840.0 88300.0 0.42 -0.6336 -0.4605 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 J07 compound treatment 378950.0 -137000.0 -0.68 232020.0 -263000.0 -1.24 -1.3591 -0.9606 3188894 PK04_102185 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCn4cc(nn4)[C@H](O)c5ccccc5)C(=O)N(Cc6cccc(c6)N7CCC7=O)c8ccccc83 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 J08 compound treatment 38510.0 -477000.0 -2.38 19630.0 -476000.0 -2.24 -3.2678 -0.9995 3069714 PK04_102186 COc1ccc(NC(=O)O[C@@H](CC=C)c2ccc(O)c3ccccc23)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 J09 compound treatment 289980.0 -226000.0 -1.13 216320.0 -279000.0 -1.31 -1.7256 -0.9971 3188895 PK04_102187 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CC(=O)N4Cc5ccccc5C[C@H]4CO)C(=O)N(Cc6cccc(c6)N7CCC7=O)c8ccccc83 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 J10 compound treatment 276820.0 -239000.0 -1.19 503680.0 8190.0 0.04 -0.8163 -0.6839 3069716 PK04_102188 CO[C@@H](C=C)[C@@H](O)c1ccc(O)c(F)c1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 J11 compound treatment 188100.0 -328000.0 -1.64 191040.0 -304000.0 -1.43 -2.1694 -0.9978 3188896 PK04_102189 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CC(=O)N(CCO)Cc4ccccc4)C(=O)N(Cc5ccc(cc5)N6CCOC6=O)c7ccccc73 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 J12 compound treatment 64000.0 -452000.0 -2.26 78120.0 -417000.0 -1.96 -2.9833 -0.9976 3069744 PK04_102190 COc1ccc(NC(=O)O[C@H]([C@@H](C)C=C)c2ccc(O)c3ccccc23)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 J13 compound treatment 135370.0 -380000.0 -1.9 145330.0 -350000.0 -1.65 -2.5077 -0.9975 3188897 PK04_102191 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CC(=O)N4Cc5ccccc5C[C@H]4CO)C(=O)N(Cc6cccc(c6)N7C(=O)c8cccc9cccc7c89)c%10ccccc%103 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 J14 compound treatment 456280.0 -59400.0 -0.3 599620.0 104000.0 0.49 0.1366 0.2386 3069746 PK04_102192 OCCOc1ccc(cc1)[C@@H](O)CC=C 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 J15 compound treatment 187890.0 -328000.0 -1.64 165120.0 -330000.0 -1.55 -2.2564 -0.9997 3069749 PK04_102193 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCn4cc(CCO)nn4)C(=O)N(Cc5cccc(c5)N6CCC6=O)c7ccccc73 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 J16 compound treatment 526400.0 10700.0 0.05 533160.0 37700.0 0.18 0.1632 0.8816 3188898 PK04_102194 CO[C@H](C=C)[C@H](OC(=O)Nc1ccc(SC)cc1)c2ccc(OCCO)cc2 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 J17 compound treatment 255360.0 -260000.0 -1.3 244860.0 -251000.0 -1.18 -1.7529 -0.9988 3188899 PK04_102195 COc1ccc(cc1)C(=O)Nc2ccc(CN3C(=O)[C@]4(O[C@H](CC(=O)N5CCC[C@H]5CO)[C@H]([C@@H]4C)[Si](C)(C)c6ccc(OC)cc6)c7ccccc37)cc2 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 J18 compound treatment 391810.0 -124000.0 -0.62 379580.0 -116000.0 -0.55 -0.8229 -0.998 3069504 PK04_102196 O[C@H](CC=C)c1ccc(O)c2ccccc12 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 J19 compound treatment 232530.0 -283000.0 -1.41 215960.0 -280000.0 -1.31 -1.9296 -0.9993 3188900 PK04_102197 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CC(=O)N4Cc5ccccc5C[C@H]4CO)C(=O)N(Cc6ccc(cc6)N7C(=O)c8cccc9cccc7c89)c%10ccccc%103 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 J20 compound treatment 445060.0 -70600.0 -0.35 495480.0 -12.0 0.0 -0.2494 -0.7072 3069264 PK04_102198 C[C@H](C=C)[C@@H](O)c1ccc(O)c2ccccc12 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 J21 mock treatment 447290.0 -68400.0 -0.34 563610.0 68100.0 0.32 -0.0149 -0.0318 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 J22 mock treatment 414720.0 -101000.0 -0.5 515080.0 19600.0 0.09 -0.2913 -0.5685 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 J23 compound treatment 224040.0 -292000.0 -1.46 262470.0 -233000.0 -1.1 -1.8049 -0.9902 3069786 PK04_102199 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CC(=O)N4CCC[C@H]4CO)C(=O)N(Cc5ccc(cc5)N6CCC6=O)c7ccccc73 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 J24 compound treatment 376640.0 -139000.0 -0.69 489520.0 -5970.0 -0.03 -0.5108 -0.7351 3188901 PK04_102200 CSc1ccc(NC(=O)O[C@H](CC=C)c2ccc(OCCO)cc2)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 K01 compound treatment 512530.0 -3130.0 -0.02 496000.0 508.0 0.0 -0.0094 -0.5923 3069787 PK04_102201 COc1ccc(cc1)[Si](C)(C)[C@@H](CCn2cc(CCO)nn2)/C=C/C 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 K02 compound treatment 112010.0 -404000.0 -2.02 286260.0 -209000.0 -0.98 -2.1215 -0.9456 3188902 PK04_102202 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCO)C(=O)N(Cc4ccccc4)c5ccc(NC(=O)[C@H](C)O)cc53 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 K03 compound treatment 513480.0 -2180.0 -0.01 598830.0 103000.0 0.49 0.336 0.6911 3188903 PK04_102203 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCn4cc(nn4)[C@H](O)c5ccccc5)C(=O)N(C)c6ccccc63 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 K04 compound treatment 389850.0 -126000.0 -0.63 157570.0 -338000.0 -1.59 -1.5683 -0.9176 3069790 PK04_102204 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCO)C(=O)N(Cc4ccccc4)c5ccc(cc53)N(C=O)c6ccccc6 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 K05 compound treatment 568480.0 52800.0 0.26 582460.0 87000.0 0.41 0.4758 0.9775 3188904 PK04_102205 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CC(=O)N4CCC[C@H]4CO)C(=O)N(C)c5c3cc(C)cc5Br 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 K06 compound treatment 17760.0 -498000.0 -2.49 29760.0 -466000.0 -2.19 -3.3074 -0.998 3189012 PK04_102206 COc1ccc(cc1)C(=O)Nc2ccc(CN3C(=O)[C@]4(O[C@H](CCO)[C@H]([C@@H]4C)[Si](C)(C)c5ccc(OC)cc5)c6ccccc36)cc2 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 K07 mock treatment 570430.0 54800.0 0.27 545680.0 50200.0 0.24 0.3603 0.9973 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 K08 mock treatment 601180.0 85500.0 0.43 609450.0 114000.0 0.54 0.681 0.9937 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 K09 compound treatment 289760.0 -226000.0 -1.13 447550.0 -47900.0 -0.23 -0.9573 -0.832 3069821 PK04_102207 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCn4cc(nn4)[C@H](O)c5ccccc5)C(=O)N(CC=C)c6ccccc63 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 K10 compound treatment 200170.0 -315000.0 -1.58 266560.0 -229000.0 -1.08 -1.8756 -0.9828 3189013 PK04_102208 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCO)C(=O)N(CC=C)c4ccc(NC(=O)C)cc43 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 K11 compound treatment 215920.0 -300000.0 -1.5 152180.0 -343000.0 -1.61 -2.2004 -0.9993 3069825 PK04_102209 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCO)C(=O)N4c5c3cc(OC)cc5C(=CC4(C)C)C 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 K12 compound treatment 232670.0 -283000.0 -1.41 164890.0 -331000.0 -1.56 -2.099 -0.9989 3189014 PK04_102210 COc1ccc(cc1)C(=O)Nc2ccc(CN3C(=O)[C@@]4(O[C@@H](CCO)[C@@H]([C@H]4C)[Si](C)(C)c5ccc(OC)cc5)c6ccccc36)cc2 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 K13 compound treatment 483780.0 -31900.0 -0.16 372030.0 -123000.0 -0.58 -0.5232 -0.8689 3189015 PK04_102211 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CC(=O)N4CCC[C@H]4CO)C(=O)N(C)c5c3cc(C)cc5Br 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 K14 compound treatment 122670.0 -393000.0 -1.96 202090.0 -293000.0 -1.38 -2.3638 -0.9851 3069831 PK04_102212 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCO)C(=O)N(Cc4cccc(c4)N5CCOC5=O)c6ccccc63 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 K15 mock treatment 599570.0 83900.0 0.42 347550.0 -148000.0 -0.7 -0.1957 -0.2409 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 K16 mock treatment 640970.0 125000.0 0.63 551250.0 55800.0 0.26 0.628 0.9255 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 K17 compound treatment 229930.0 -286000.0 -1.43 175930.0 -320000.0 -1.5 -2.072 -0.9997 3189016 PK04_102213 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCO)C(=O)N(CC=C)c4ccc(cc43)N5C(=O)COc6ccccc56 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 K18 compound treatment 166750.0 -349000.0 -1.74 162090.0 -333000.0 -1.57 -2.3411 -0.9986 3069867 PK04_102214 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCO)C(=O)N(Cc4ccccc4)c5ccc(NC(=O)C)cc53 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 K19 compound treatment 184840.0 -331000.0 -1.65 177550.0 -318000.0 -1.5 -2.2258 -0.9988 3189017 PK04_102215 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCO)C(=O)N(Cc4ccccc4)c5ccc(cc53)N6C(=O)c7cccc8cccc6c78 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 K20 compound treatment 170610.0 -345000.0 -1.72 157490.0 -338000.0 -1.59 -2.3428 -0.9992 3069873 PK04_102216 COc1ccc(cc1)C(=O)Nc2ccc3N(CC=C)C(=O)[C@@]4(O[C@@H](CCO)[C@@H]([C@H]4C)[Si](C)(C)c5ccc(OC)cc5)c3c2 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 K21 compound treatment 154600.0 -361000.0 -1.8 173440.0 -322000.0 -1.51 -2.3463 -0.9962 3189018 PK04_102217 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCO)C(=O)N(Cc4ccc(cc4)N5C(=O)c6cccc7cccc5c67)c8ccccc83 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 K22 compound treatment 284680.0 -231000.0 -1.15 171840.0 -324000.0 -1.52 -1.8922 -0.9906 3189019 PK04_102218 COc1ccc(cc1)C(=O)Nc2ccc(CN3C(=O)[C@]4(O[C@H](CCn5cc(CCO)nn5)[C@H]([C@@H]4C)[Si](C)(C)c6ccc(OC)cc6)c7ccccc37)cc2 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 K23 mock treatment 464490.0 -51200.0 -0.26 652000.0 157000.0 0.74 0.3398 0.4361 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 K24 mock treatment 510790.0 -4870.0 -0.02 602740.0 107000.0 0.5 0.3395 0.6722 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 L01 compound treatment 418250.0 -97400.0 -0.49 436400.0 -59100.0 -0.28 -0.5406 -0.9647 3069879 PK04_102219 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CC(=O)N4CCC[C@H]4CO)C(=O)N(Cc5cccc(c5)N6C(=O)c7cccc8cccc6c78)c9ccccc93 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 L02 compound treatment 478640.0 -37000.0 -0.18 470310.0 -25200.0 -0.12 -0.2145 -0.9768 3189020 PK04_102220 C[C@@H](C=C)[C@H](O)c1ccc(OCCO)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 L03 compound treatment 309410.0 -206000.0 -1.03 421350.0 -74100.0 -0.35 -0.975 -0.8965 3189021 PK04_102221 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CC(=O)N4Cc5ccccc5C[C@H]4CO)C(=O)N(Cc6ccc(cc6)N7C(=O)c8cccc9cccc7c89)c%10ccccc%103 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 L04 compound treatment 331290.0 -184000.0 -0.92 604960.0 109000.0 0.51 -0.2871 -0.2721 3069907 PK04_102222 C[C@H](C=C)[C@@H](O)c1ccc(OCCO)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 L05 compound treatment 394090.0 -122000.0 -0.61 180800.0 -315000.0 -1.48 -1.476 -0.9226 3189022 PK04_102223 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CC(=O)N4Cc5ccccc5C[C@H]4CO)C(=O)N(Cc6ccc(cc6)N7CCC7=O)c8ccccc83 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 L06 compound treatment 199580.0 -316000.0 -1.58 364400.0 -131000.0 -0.62 -1.5523 -0.9159 3069909 PK04_102224 C[C@@H](C=C)[C@@H](O)c1ccc(O)c2ccccc12 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 L07 mock treatment 565150.0 49500.0 0.25 244000.0 -251000.0 -1.18 -0.6617 -0.5475 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 L08 mock treatment 514310.0 -1350.0 -0.01 622180.0 127000.0 0.6 0.4166 0.699 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 L09 compound treatment 167470.0 -348000.0 -1.74 250320.0 -245000.0 -1.15 -2.0451 -0.9801 3189023 PK04_102225 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCO)C(=O)N(Cc4cccc(c4)N5CCC5=O)c6ccccc63 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 L10 compound treatment 403390.0 -112000.0 -0.56 467410.0 -28100.0 -0.13 -0.4899 -0.8504 3069912 PK04_102226 COc1ccc(NC(=O)O[C@H]([C@@H](C)C=C)c2ccc(OCCO)cc2)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 L11 compound treatment 307910.0 -208000.0 -1.04 466300.0 -29200.0 -0.14 -0.8308 -0.7938 3189024 PK04_102227 COc1ccc(cc1)C(=O)Nc2cccc(CN3C(=O)[C@@]4(O[C@@H](CC(=O)N5CCC[C@H]5CO)[C@@H]([C@H]4C)[Si](C)(C)c6ccc(OC)cc6)c7ccccc37)c2 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 L12 compound treatment 542890.0 27200.0 0.14 592500.0 97000.0 0.46 0.4188 0.8796 3069746 PK04_102228 OCCOc1ccc(cc1)[C@@H](O)CC=C 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 L13 compound treatment 171680.0 -344000.0 -1.72 143200.0 -352000.0 -1.66 -2.3865 -0.9998 3069917 PK04_102229 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCO)C(=O)N(CC=C)c4ccc(cc43)N5CCC5=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 L14 compound treatment 238410.0 -277000.0 -1.38 236920.0 -259000.0 -1.22 -1.8392 -0.9979 3069920 PK04_102230 O[C@@H](CC=C)c1ccc(O)c(F)c1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 L15 mock treatment 568380.0 52700.0 0.26 503740.0 8250.0 0.04 0.2136 0.8026 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 L16 mock treatment 613220.0 97600.0 0.49 604820.0 109000.0 0.51 0.7082 0.9996 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 L17 compound treatment 418200.0 -97500.0 -0.49 377230.0 -118000.0 -0.56 -0.7375 -0.9978 3189025 PK04_102231 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CC(=O)N4CCC[C@H]4CO)C(=O)N(Cc5cccc(c5)N6CCOC6=O)c7ccccc73 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 L18 compound treatment 441320.0 -74300.0 -0.37 604580.0 109000.0 0.51 0.1003 0.1583 3069953 PK04_102232 CO[C@H](C=C)[C@H](O)c1ccc(OCCO)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 L19 compound treatment 137970.0 -378000.0 -1.89 139420.0 -356000.0 -1.67 -2.5182 -0.9982 3189026 PK04_102233 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCn4cc(CCO)nn4)C(=O)N(Cc5ccc(cc5)N6CCC6=O)c7ccccc73 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 L20 compound treatment 470420.0 -45200.0 -0.23 387320.0 -108000.0 -0.51 -0.5196 -0.9332 3069956 PK04_102234 CO[C@@H](C=C)[C@@H](O)c1ccc(OC)c(O)c1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 L21 compound treatment 461760.0 -53900.0 -0.27 493340.0 -2150.0 -0.01 -0.1975 -0.7332 3189027 PK04_102235 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CC(=O)N4CCC[C@H]4CO)C(=O)N(Cc5cccc(c5)N6CCCCC6=O)c7ccccc73 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 L22 compound treatment 408230.0 -107000.0 -0.54 545130.0 49600.0 0.23 -0.2143 -0.3663 3069961 PK04_102236 CO[C@H](C=C)[C@H](OC(=O)Nc1ccc(OC)cc1)c2ccc(OCCO)cc2 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 L23 mock treatment 444920.0 -70700.0 -0.35 473840.0 -21700.0 -0.1 -0.3219 -0.8753 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 L24 mock treatment 491520.0 -24100.0 -0.12 277920.0 -218000.0 -1.02 -0.8089 -0.785 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 M01 compound treatment 166630.0 -349000.0 -1.74 310530.0 -185000.0 -0.87 -1.8478 -0.9484 3069962 PK04_102237 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CC(=O)N(CCO)Cc4ccccc4)C(=O)N(c5ccccc53)c6ccccc6 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 M02 compound treatment 74460.0 -441000.0 -2.2 132350.0 -363000.0 -1.71 -2.766 -0.9921 3188628 PK04_102238 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCn4cc(CCO)nn4)C(=O)N(CC=C)c5ccc(cc53)N6C(=O)c7cccc8cccc6c78 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 M03 compound treatment 308100.0 -208000.0 -1.04 181760.0 -314000.0 -1.48 -1.7765 -0.9851 3189028 PK04_102239 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CC(=O)N4Cc5ccccc5C[C@H]4CO)C(=O)N(C)c6c3cc(C)cc6Br 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 M04 compound treatment 125310.0 -390000.0 -1.95 359230.0 -136000.0 -0.64 -1.8318 -0.8926 3189141 PK04_102240 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCO)C(=O)N(CC=C)c4ccc(cc43)N5CCCCC5=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 M05 compound treatment 100660.0 -415000.0 -2.07 166290.0 -329000.0 -1.55 -2.5606 -0.9897 3069277 PK04_102241 COc1ccc(cc1)[Si](C)(C)[C@@H](CC(=O)N(CCO)Cc2ccccc2)/C=C/C 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 M06 compound treatment 39950.0 -476000.0 -2.38 89230.0 -406000.0 -1.91 -3.0313 -0.9942 3189142 PK04_102242 COc1ccc(cc1)C(=O)Nc2cccc(CN3C(=O)[C@@]4(O[C@@H](CCn5cc(CCO)nn5)[C@@H]([C@H]4C)[Si](C)(C)c6ccc(OC)cc6)c7ccccc37)c2 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 M07 compound treatment 153860.0 -362000.0 -1.81 325120.0 -170000.0 -0.8 -1.8444 -0.9331 3189143 PK04_102243 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCO)C(=O)N4c5c3cc(OC)cc5C(=CC4(C)C)C 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 M08 compound treatment 155470.0 -360000.0 -1.8 142080.0 -353000.0 -1.66 -2.4475 -0.9992 3069284 PK04_102244 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCO)C(=O)N(Cc4ccccc4)c5ccc(NC(=O)[C@H](C)O)cc53 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 M09 mock treatment 484160.0 -31500.0 -0.16 606200.0 111000.0 0.52 0.257 0.4724 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 M10 mock treatment 555140.0 39500.0 0.2 581600.0 86100.0 0.41 0.4258 0.9453 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 M11 compound treatment 497370.0 -18300.0 -0.09 459170.0 -36300.0 -0.17 -0.1854 -0.957 3189144 PK04_102245 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CC(=O)N4CCC[C@H]4CO)C(=O)N(C)c5ccccc53 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 M12 compound treatment 202140.0 -314000.0 -1.57 275010.0 -220000.0 -1.04 -1.8406 -0.98 3189145 PK04_102246 COc1ccc(cc1)C(=O)Nc2ccc(CN3C(=O)[C@]4(O[C@H](CCn5cc(nn5)[C@H](O)c6ccccc6)[C@H]([C@@H]4C)[Si](C)(C)c7ccc(OC)cc7)c8ccccc38)cc2 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 M13 mock treatment 589440.0 73800.0 0.37 552200.0 56700.0 0.27 0.4492 0.9874 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 M14 mock treatment 575570.0 59900.0 0.3 586300.0 90800.0 0.43 0.5136 0.9848 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 M15 compound treatment 206790.0 -309000.0 -1.54 138030.0 -357000.0 -1.68 -2.2797 -0.9991 3189146 PK04_102247 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCn4cc(CCO)nn4)C(=O)N(CC=C)c5ccccc53 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 M16 compound treatment 385300.0 -130000.0 -0.65 211270.0 -284000.0 -1.34 -1.4057 -0.9453 3189147 PK04_102248 COc1ccc(cc1)C(=O)Nc2ccc(CN3C(=O)[C@@]4(O[C@@H](CCn5cc(nn5)[C@H](O)c6ccccc6)[C@@H]([C@H]4C)[Si](C)(C)c7ccc(OC)cc7)c8ccccc38)cc2 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 M17 compound treatment 126200.0 -389000.0 -1.95 114130.0 -381000.0 -1.79 -2.6439 -0.9992 3069327 PK04_102249 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCO)C(=O)N(Cc4ccccc4)c5ccc(NC(=O)C)cc53 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 M18 compound treatment 165070.0 -351000.0 -1.75 257280.0 -238000.0 -1.12 -2.0305 -0.9767 3189148 PK04_102250 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCO)C(=O)N(CC=C)c4ccc(cc43)N5CCOC5=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 M19 compound treatment 194560.0 -321000.0 -1.6 363400.0 -132000.0 -0.62 -1.5734 -0.9148 3069330 PK04_102251 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCn4cc(nn4)[C@H](O)c5ccccc5)C(=O)N(Cc6ccc(cc6)N7C(=O)c8cccc9cccc7c89)c%10ccccc%103 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 M20 compound treatment 267090.0 -249000.0 -1.24 125720.0 -370000.0 -1.74 -2.1077 -0.9863 3189149 PK04_102252 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCO)C(=O)N(Cc4cccc(c4)N5CCCCC5=O)c6ccccc63 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 M21 compound treatment 146320.0 -369000.0 -1.84 156750.0 -339000.0 -1.59 -2.431 -0.9973 3189150 PK04_102253 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCO)C(=O)N(Cc4cccc(c4)N5C(=O)c6ccccc6Oc7ccccc57)c8ccccc83 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 M22 compound treatment 251680.0 -264000.0 -1.32 268840.0 -227000.0 -1.07 -1.6861 -0.9944 3189151 PK04_102254 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCn4cc(nn4)[C@H](O)c5ccccc5)C(=O)N(Cc6cccc(c6)N7CCOC7=O)c8ccccc83 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 M23 compound treatment 144220.0 -371000.0 -1.86 189820.0 -306000.0 -1.44 -2.3285 -0.9921 3189152 PK04_102255 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCO)C(=O)N(Cc4ccccc4)c5ccc(cc53)N6C(=O)c7cccc8cccc6c78 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 M24 compound treatment 114330.0 -401000.0 -2.0 129460.0 -366000.0 -1.72 -2.6348 -0.9971 3069375 PK04_102256 COc1ccc(cc1)C(=O)Nc2cccc(CN3C(=O)[C@@]4(O[C@@H](CCO)[C@@H]([C@H]4C)[Si](C)(C)c5ccc(OC)cc5)c6ccccc36)c2 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 N01 compound treatment 181340.0 -334000.0 -1.67 180730.0 -315000.0 -1.48 -2.2276 -0.9982 3189153 PK04_102257 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CC(=O)N(CCO)Cc4ccccc4)C(=O)N(Cc5cccc(c5)N6C(=O)c7cccc8cccc6c78)c9ccccc93 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 N02 compound treatment 505450.0 -10200.0 -0.05 533600.0 38100.0 0.18 0.0907 0.4866 3069379 PK04_102258 CSc1ccc(NC(=O)O[C@@H]([C@H](C)C=C)c2ccc(OCCO)cc2)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 N03 compound treatment 191800.0 -324000.0 -1.62 574580.0 79100.0 0.37 -0.8807 -0.5306 3189154 PK04_102259 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCn4cc(nn4)[C@H](O)c5ccccc5)C(=O)N(Cc6ccc(cc6)N7CCC7=O)c8ccccc83 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 N04 compound treatment 219100.0 -297000.0 -1.48 552000.0 56500.0 0.27 -0.8594 -0.5711 3069716 PK04_102260 CO[C@@H](C=C)[C@@H](O)c1ccc(O)c(F)c1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 N05 compound treatment 143450.0 -372000.0 -1.86 397840.0 -97700.0 -0.46 -1.6393 -0.8561 3069403 PK04_102261 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCn4cc(CCO)nn4)C(=O)N(CC=C)c5ccc(cc53)N6CCC6=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 N06 compound treatment 462970.0 -52700.0 -0.26 534190.0 38700.0 0.18 -0.0574 -0.1793 3069417 PK04_102262 C[C@H](C=C)[C@H](O)c1ccc(OCCO)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 N07 compound treatment 178900.0 -337000.0 -1.68 231870.0 -264000.0 -1.24 -2.0661 -0.9888 3189155 PK04_102263 COc1ccc(cc1)C(=O)Nc2cccc(CN3C(=O)[C@]4(O[C@H](CC(=O)N(CCO)Cc5ccccc5)[C@H]([C@@H]4C)[Si](C)(C)c6ccc(OC)cc6)c7ccccc37)c2 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 N08 compound treatment 463620.0 -52000.0 -0.26 468160.0 -27300.0 -0.13 -0.2747 -0.9473 3069421 PK04_102264 CO[C@@H](C=C)[C@@H](OC(=O)Nc1ccc(SC)cc1)c2ccc(OCCO)cc2 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 N09 mock treatment 515070.0 -593.0 0.0 527290.0 31800.0 0.15 0.1037 0.693 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 N10 mock treatment 462320.0 -53300.0 -0.27 556330.0 60800.0 0.29 0.014 0.0357 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 N11 compound treatment 248060.0 -268000.0 -1.34 361320.0 -134000.0 -0.63 -1.3913 -0.9413 3189156 PK04_102265 COc1ccc(cc1)C(=O)Nc2cccc(CN3C(=O)[C@@]4(O[C@@H](CC(=O)N5Cc6ccccc6C[C@H]5CO)[C@@H]([C@H]4C)[Si](C)(C)c7ccc(OC)cc7)c8ccccc38)c2 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 N12 compound treatment 273120.0 -243000.0 -1.21 279200.0 -216000.0 -1.02 -1.576 -0.9962 3069424 PK04_102266 CO[C@@H](C=C)[C@@H](OC(=O)Nc1ccc(OC)cc1)c2ccc(O)c(F)c2 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 N13 mock treatment 496610.0 -19100.0 -0.1 529760.0 34300.0 0.16 0.0467 0.2494 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 N14 mock treatment 566280.0 50600.0 0.25 505560.0 10100.0 0.05 0.2122 0.8252 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 N15 compound treatment 176100.0 -340000.0 -1.7 205090.0 -290000.0 -1.37 -2.1651 -0.9942 3189268 PK04_102267 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CC(=O)N4Cc5ccccc5C[C@H]4CO)C(=O)N(Cc6cccc(c6)N7C(=O)c8cccc9cccc7c89)c%10ccccc%103 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 N16 compound treatment 448000.0 -67700.0 -0.34 556320.0 60800.0 0.29 -0.0366 -0.0828 3069404 PK04_102268 C[C@@H](C=C)[C@@H](O)c1ccc(OCCO)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 N17 compound treatment 289440.0 -226000.0 -1.13 317280.0 -178000.0 -0.84 -1.3917 -0.9892 3069428 PK04_102269 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CC(=O)N4CCC[C@H]4CO)C(=O)N(Cc5cccc(c5)N6CCC6=O)c7ccccc73 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 N18 compound treatment 459970.0 -55700.0 -0.28 544670.0 49200.0 0.23 -0.0331 -0.0916 3189269 PK04_102270 CO[C@@H](C=C)[C@@H](OC(=O)Nc1ccc(OC)cc1)c2ccc(OCCO)cc2 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 N19 compound treatment 199370.0 -316000.0 -1.58 215680.0 -280000.0 -1.32 -2.0477 -0.9959 3070277 PK04_102271 COc1ccc(cc1)C(=O)Nc2ccc(CN3C(=O)[C@@]4(O[C@@H](CC(=O)N5CCC[C@H]5CO)[C@@H]([C@H]4C)[Si](C)(C)c6ccc(OC)cc6)c7ccccc37)cc2 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 N20 compound treatment 403560.0 -112000.0 -0.56 189710.0 -306000.0 -1.44 -1.4129 -0.9155 3069270 PK04_102272 CO[C@@H](C=C)[C@@H](O)c1ccc(OCCO)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 N21 compound treatment 146880.0 -369000.0 -1.84 123750.0 -372000.0 -1.75 -2.5388 -0.9997 3070278 PK04_102273 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCO)C(=O)N(Cc4cccc(c4)N5CCC5=O)c6ccccc63 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 N22 compound treatment 220800.0 -295000.0 -1.47 184250.0 -311000.0 -1.46 -2.0765 -1.0 3070279 PK04_102274 CSc1ccc(NC(=O)O[C@H](CC=C)c2ccc(O)c(F)c2)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 N23 compound treatment 305490.0 -210000.0 -1.05 241810.0 -254000.0 -1.19 -1.586 -0.998 3070280 PK04_102275 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CC(=O)N(CCO)Cc4ccccc4)C(=O)N(Cc5cccc(c5)N6C(=O)COc7ccccc67)c8ccccc83 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 N24 compound treatment 356770.0 -159000.0 -0.79 513770.0 18300.0 0.09 -0.5004 -0.6268 3189270 PK04_102276 CO[C@@H](C=C)[C@@H](OC(=O)Nc1ccc(SC)cc1)c2ccc(OC)c(O)c2 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 O01 compound treatment 519840.0 4180.0 0.02 559220.0 63700.0 0.3 0.2267 0.7545 3189271 PK04_102277 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CC(=O)N4CCC[C@H]4CO)C(=O)N(c5ccccc53)c6ccccc6 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 O02 compound treatment 113130.0 -403000.0 -2.01 188700.0 -307000.0 -1.44 -2.442 -0.9868 3070281 PK04_102278 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCO)C(=O)N(Cc4cccc(c4)N(C=O)c5ccccc5)c6ccccc63 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 O03 compound treatment 251530.0 -264000.0 -1.32 412370.0 -83100.0 -0.39 -1.2093 -0.8789 3189272 PK04_102279 COc1ccc(cc1)[Si](C)(C)[C@@H](CC(=O)N2CCC[C@H]2CO)/C=C/C 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 O04 compound treatment 68590.0 -447000.0 -2.23 241610.0 -254000.0 -1.19 -2.4233 -0.957 3189273 PK04_102280 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCO)C(=O)N(Cc4cccc(NC(=O)[C@H](C)O)c4)c5ccccc53 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 O05 compound treatment 107400.0 -408000.0 -2.04 150500.0 -345000.0 -1.62 -2.5893 -0.9936 3070282 PK04_102281 COc1ccc(cc1)[Si](C)(C)[C@H](CC(=O)N(CCO)Cc2ccccc2)/C=C/C 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 O06 compound treatment 24390.0 -491000.0 -2.45 76000.0 -419000.0 -1.97 -3.1302 -0.9942 3189274 PK04_102282 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCO)C(=O)N(CC=C)c4ccc(cc43)N5C(=O)c6cccc7cccc5c67 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 O07 compound treatment 175060.0 -341000.0 -1.7 289340.0 -206000.0 -0.97 -1.8885 -0.9645 3070283 PK04_102283 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CC(=O)N(CCO)Cc4ccccc4)C(=O)N(C)c5c3cc(C)cc5Br 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 O08 compound treatment 173940.0 -342000.0 -1.71 209440.0 -286000.0 -1.35 -2.1583 -0.9931 3189275 PK04_102284 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCO)C(=O)N(Cc4ccccc4)c5ccc(cc53)N(C=O)c6ccccc6 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 O09 compound treatment 162800.0 -353000.0 -1.76 187520.0 -308000.0 -1.45 -2.2705 -0.9953 3189276 PK04_102285 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CC(=O)N4Cc5ccccc5C[C@H]4CO)C(=O)N(C)c6ccccc63 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 O10 compound treatment 157480.0 -358000.0 -1.79 174940.0 -321000.0 -1.51 -2.3311 -0.9964 3070284 PK04_102286 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCn4cc(CCO)nn4)C(=O)N(Cc5ccc(cc5)N6CCOC6=O)c7ccccc73 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 O11 mock treatment 429530.0 -86100.0 -0.43 518750.0 23300.0 0.11 -0.2268 -0.511 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 O12 mock treatment 586100.0 70400.0 0.35 579970.0 84500.0 0.4 0.5297 0.9982 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 O13 compound treatment 200320.0 -315000.0 -1.57 189920.0 -306000.0 -1.44 -2.13 -0.999 3189277 PK04_102287 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCO)C(=O)N(C)c4ccccc43 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 O14 compound treatment 287570.0 -228000.0 -1.14 217380.0 -278000.0 -1.31 -1.7305 -0.9976 3189278 PK04_102288 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCO)C(=O)N(CC=C)c4ccc(NC(=O)[C@H](C)O)cc43 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 O15 compound treatment 154280.0 -361000.0 -1.8 163870.0 -332000.0 -1.56 -2.3792 -0.9974 3070285 PK04_102289 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCO)C(=O)N(c4ccccc43)c5ccccc5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 O16 compound treatment 173280.0 -342000.0 -1.71 155480.0 -340000.0 -1.6 -2.3401 -0.9994 3189279 PK04_102290 COc1ccc(cc1)C(=O)Nc2ccc3N(CC=C)C(=O)[C@]4(O[C@H](CCn5cc(nn5)[C@H](O)c6ccccc6)[C@H]([C@@H]4C)[Si](C)(C)c7ccc(OC)cc7)c3c2 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 O17 compound treatment 243770.0 -272000.0 -1.36 247060.0 -248000.0 -1.17 -1.7865 -0.9972 3070286 PK04_102291 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCn4cc(nn4)[C@H](O)c5ccccc5)C(=O)N(CC=C)c6ccc(cc63)N7C(=O)c8cccc9cccc7c89 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 O18 compound treatment 190630.0 -325000.0 -1.62 155880.0 -340000.0 -1.6 -2.2774 -1.0 3189280 PK04_102292 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCO)C(=O)N(Cc4ccccc4)c5ccc(cc53)N6CCCCC6=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 O19 compound treatment 160660.0 -355000.0 -1.77 177600.0 -318000.0 -1.5 -2.3111 -0.9964 3189281 PK04_102293 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCn4cc(CCO)nn4)C(=O)N(Cc5cccc(c5)N6C(=O)c7cccc8cccc6c78)c9ccccc93 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 O20 compound treatment 140490.0 -375000.0 -1.87 132500.0 -363000.0 -1.71 -2.5323 -0.9989 3070287 PK04_102294 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCO)C(=O)N(Cc4ccc(cc4)N5CCCCC5=O)c6ccccc63 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 O21 compound treatment 117000.0 -399000.0 -1.99 125060.0 -370000.0 -1.74 -2.64 -0.9978 3189282 PK04_102295 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCO)C(=O)N(Cc4cccc(c4)N5C(=O)COc6ccccc56)c7ccccc73 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 O22 compound treatment 136210.0 -379000.0 -1.9 142850.0 -353000.0 -1.66 -2.513 -0.9978 3070288 PK04_102296 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCO)C(=O)N(CC=C)c4ccc(cc43)N5C(=O)c6ccccc6Oc7ccccc57 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 O23 compound treatment 174530.0 -341000.0 -1.7 147740.0 -348000.0 -1.64 -2.3614 -0.9998 3189283 PK04_102297 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCn4cc(CCO)nn4)C(=O)N(CC=C)c5ccc(cc53)N6C(=O)c7cccc8cccc6c78 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 O24 compound treatment 119390.0 -396000.0 -1.98 173970.0 -322000.0 -1.51 -2.4689 -0.9912 3189284 PK04_102298 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCO)C(=O)N(Cc4ccc(NC(=O)C)cc4)c5ccccc53 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 P01 compound treatment 143360.0 -372000.0 -1.86 176180.0 -319000.0 -1.5 -2.3769 -0.9944 3070289 PK04_102299 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCn4cc(CCO)nn4)C(=O)N(Cc5ccc(cc5)N6CCC6=O)c7ccccc73 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 P02 compound treatment 440320.0 -75300.0 -0.38 522770.0 27300.0 0.13 -0.1754 -0.4411 3069953 PK04_102300 CO[C@H](C=C)[C@H](O)c1ccc(OCCO)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 P03 compound treatment 149850.0 -366000.0 -1.83 129060.0 -366000.0 -1.72 -2.5107 -0.9996 3189285 PK04_102301 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CC(=O)N4Cc5ccccc5C[C@H]4CO)C(=O)N(Cc6cccc(c6)N7C(=O)COc8ccccc78)c9ccccc93 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 P04 compound treatment 268160.0 -248000.0 -1.24 281290.0 -214000.0 -1.01 -1.5865 -0.9948 3070290 PK04_102302 C[C@@H](C=C)[C@H](O)c1ccc(O)c2ccccc12 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 P05 compound treatment 227680.0 -288000.0 -1.44 218420.0 -277000.0 -1.3 -1.9386 -0.9988 3189394 PK04_102303 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCn4cc(CCO)nn4)C(=O)N(C)c5c3cc(C)cc5Br 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 P06 compound treatment 338250.0 -177000.0 -0.89 216900.0 -279000.0 -1.31 -1.5532 -0.9818 3069907 PK04_102304 C[C@H](C=C)[C@@H](O)c1ccc(OCCO)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 P07 compound treatment 204810.0 -311000.0 -1.55 392350.0 -103000.0 -0.49 -1.4409 -0.8858 3189395 PK04_102305 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CCn4cc(nn4)[C@H](O)c5ccccc5)C(=O)N(Cc6cccc(c6)N7CCC7=O)c8ccccc83 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 P08 compound treatment 431290.0 -84400.0 -0.42 465760.0 -29700.0 -0.14 -0.3969 -0.8938 3069314 PK04_102306 CO[C@H](C=C)[C@H](O)c1ccc(O)c(F)c1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 P09 compound treatment 209490.0 -306000.0 -1.53 283260.0 -212000.0 -1.0 -1.7872 -0.9786 3070291 PK04_102307 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CC(=O)N(CCO)Cc4ccccc4)C(=O)N(Cc5cccc(c5)N6CCCCC6=O)c7ccccc73 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 P10 compound treatment 319950.0 -196000.0 -0.98 361870.0 -134000.0 -0.63 -1.1356 -0.9772 3189396 PK04_102308 CSc1ccc(NC(=O)O[C@@H]([C@@H](C)C=C)c2ccc(OCCO)cc2)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 P11 mock treatment 460650.0 -55000.0 -0.27 442840.0 -52700.0 -0.25 -0.3694 -0.9987 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 P12 mock treatment 302800.0 -213000.0 -1.06 388530.0 -107000.0 -0.5 -1.1075 -0.9416 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 P13 compound treatment 154910.0 -361000.0 -1.8 223650.0 -272000.0 -1.28 -2.1782 -0.9859 3189397 PK04_102309 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CC(=O)N(CCO)Cc4ccccc4)C(=O)N(Cc5cccc(c5)N6C(=O)c7cccc8cccc6c78)c9ccccc93 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 P14 compound treatment 252820.0 -263000.0 -1.31 412500.0 -83000.0 -0.39 -1.2043 -0.8793 3070292 PK04_102310 OCCOc1ccc(cc1)[C@H](O)CC=C 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 P15 compound treatment 201720.0 -314000.0 -1.57 178400.0 -317000.0 -1.49 -2.1634 -0.9997 3070293 PK04_102311 COc1ccc(cc1)C(=O)Nc2cccc(CN3C(=O)[C@@]4(O[C@@H](CC(=O)N(CCO)Cc5ccccc5)[C@@H]([C@H]4C)[Si](C)(C)c6ccc(OC)cc6)c7ccccc37)c2 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 P16 compound treatment 340840.0 -175000.0 -0.87 223810.0 -272000.0 -1.28 -1.521 -0.9828 3070292 PK04_102312 OCCOc1ccc(cc1)[C@H](O)CC=C 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 P17 compound treatment 206720.0 -309000.0 -1.54 196770.0 -299000.0 -1.41 -2.0846 -0.9989 3189398 PK04_102313 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CC(=O)N4CCC[C@H]4CO)C(=O)N(Cc5ccc(cc5)N6CCOC6=O)c7ccccc73 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 P18 compound treatment 284720.0 -231000.0 -1.15 240080.0 -255000.0 -1.2 -1.6651 -0.9998 3070294 PK04_102314 CO[C@@H](C=C)[C@@H](OC(=O)Nc1ccc(SC)cc1)c2ccc(O)c(F)c2 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 P19 compound treatment 160420.0 -355000.0 -1.77 167850.0 -328000.0 -1.54 -2.3443 -0.9975 3189399 PK04_102315 COc1ccc(cc1)[Si](C)(C)[C@@H]2[C@@H](C)[C@@]3(O[C@H]2CC(=O)N4CCC[C@H]4CO)C(=O)N(Cc5cccc(c5)N6C(=O)COc7ccccc67)c8ccccc83 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 P20 compound treatment 248960.0 -267000.0 -1.33 180970.0 -315000.0 -1.48 -1.988 -0.9986 3070290 PK04_102316 C[C@@H](C=C)[C@H](O)c1ccc(O)c2ccccc12 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 P21 compound treatment 119040.0 -397000.0 -1.98 119120.0 -376000.0 -1.77 -2.6525 -0.9984 3189400 PK04_102317 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCO)C(=O)N(Cc4ccccc4)c5ccc(cc53)N6CCC6=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 P22 compound treatment 212410.0 -303000.0 -1.51 374080.0 -121000.0 -0.57 -1.4748 -0.9111 3070295 PK04_102318 COc1ccc(NC(=O)O[C@@H]([C@H](C)C=C)c2ccc(OCCO)cc2)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 P23 compound treatment 124000.0 -392000.0 -1.96 174960.0 -321000.0 -1.51 -2.4493 -0.9917 3189401 PK04_102319 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCn4cc(nn4)[C@H](O)c5ccccc5)C(=O)N(C)c6c3cc(C)cc6Br 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2102 P24 compound treatment 397480.0 -118000.0 -0.59 192270.0 -303000.0 -1.43 -1.4259 -0.9238 3414053 PK04_102320 OCCCOc1ccc(cc1)C2=N[C@](Cc3ccccc3)([C@H](O2)c4ccccc4)C(=O)NO 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 A01 compound treatment 411450.0 60600.0 0.3 222950.0 -172000.0 -0.81 -0.357 -0.414 3221174 PK04_130001 COC(=O)c1ccc(cc1)[C@@H]2C[C@H](OCCCCO)OC(=C2)C(=O)N[C@@H]3[C@H](O)Cc4ccccc34 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 A02 compound treatment 426430.0 75600.0 0.38 163040.0 -232000.0 -1.09 -0.5034 -0.4366 3211805 PK04_130002 CO[C@H](CCO)[C@H](OC(=O)Nc1ccc(SC)cc1)c2ccc(OCCO)cc2 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 A03 compound treatment 453760.0 103000.0 0.51 472970.0 78300.0 0.37 0.6239 0.9867 3221177 PK04_130003 Cn1c(cc(=O)n1c2ccccc2)[C@@H]3C[C@H](OCCCCO)OC(=C3)C(=O)NCc4ccccc4F 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 A04 compound treatment 189920.0 -161000.0 -0.8 415710.0 21100.0 0.1 -0.4983 -0.6152 3080218 PK04_130004 OCCC[C@@H](O)c1ccc(OCCO)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 A05 compound treatment 422340.0 71500.0 0.36 410920.0 16300.0 0.08 0.3066 0.8397 3221180 PK04_130005 OCCCCO[C@H]1C[C@H](C=C(O1)C(=O)Nc2ccc(O)cc2)c3cccs3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 A06 compound treatment 419580.0 68700.0 0.34 285440.0 -109000.0 -0.51 -0.1205 -0.1951 3211801 PK04_130006 CSc1ccc(NC(=O)O[C@H](CCCO)c2ccc(OCCO)cc2)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 A07 compound treatment 196060.0 -155000.0 -0.77 284260.0 -110000.0 -0.52 -0.9138 -0.9812 3221183 PK04_130007 OCCCCO[C@H]1C[C@H](C=C(O1)C(=O)Nc2ccccc2O)c3cccs3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 A08 compound treatment 136590.0 -214000.0 -1.07 181460.0 -213000.0 -1.0 -1.4657 -0.9995 3080220 PK04_130008 COc1ccc(NC(=O)O[C@@H](CC=C)c2ccc(OCCO)cc2)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 A09 compound treatment 174800.0 -176000.0 -0.88 396700.0 2060.0 0.01 -0.6149 -0.6993 3221185 PK04_130009 OCCCCO[C@H]1C[C@H](C=C(O1)C(=O)Nc2ccc(O)cc2)c3coc4ccccc4c3=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 A10 compound treatment 438980.0 88100.0 0.44 184070.0 -211000.0 -0.99 -0.3891 -0.359 3080222 PK04_130010 CO[C@H](CCO)[C@H](OC(=O)Nc1ccc(OC)cc1)c2ccc(OCCO)cc2 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 A11 compound treatment 338760.0 -12100.0 -0.06 331240.0 -63400.0 -0.3 -0.2536 -0.8335 3221188 PK04_130011 OCCCCO[C@H]1C[C@H](C=C(O1)C(=O)NCc2ccc(Cl)cc2)c3coc4ccccc4c3=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 A12 compound treatment 385470.0 34600.0 0.17 146200.0 -248000.0 -1.17 -0.7041 -0.596 3211814 PK04_130012 C[C@H](CCO)[C@@H](O)c1ccc(OCCO)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 A13 mock treatment 151380.0 -199000.0 -1.0 179540.0 -215000.0 -1.01 -1.4199 -1.0 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 A14 mock treatment 166670.0 -184000.0 -0.92 207360.0 -187000.0 -0.88 -1.2734 -0.9998 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 A15 compound treatment 168350.0 -183000.0 -0.91 174790.0 -220000.0 -1.03 -1.3758 -0.998 3221191 PK04_130013 OCCCCCCNC(=O)C1=C[C@@H](C[C@H](OCCCCO)O1)c2coc3ccccc3c2=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 A16 compound treatment 268750.0 -82100.0 -0.41 429660.0 35000.0 0.16 -0.1735 -0.3926 3080206 PK04_130014 CSc1ccc(NC(=O)O[C@H](CCCO)c2ccc(O)c(F)c2)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 A17 compound treatment 194240.0 -157000.0 -0.78 515540.0 121000.0 0.57 -0.151 -0.1561 3221194 PK04_130015 Cn1c(cc(=O)n1c2ccccc2)[C@@H]3C[C@H](OCCCCO)OC(=C3)C(=O)N[C@@H]4[C@H](O)Cc5ccccc45 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 A18 compound treatment 201540.0 -149000.0 -0.75 289000.0 -106000.0 -0.5 -0.8787 -0.9805 3211690 PK04_130016 COc1ccc(NC(=O)O[C@H](CCCO)c2ccc(O)c(F)c2)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 A19 compound treatment 239520.0 -111000.0 -0.56 149290.0 -245000.0 -1.15 -1.2092 -0.944 3221197 PK04_130017 OCCCCO[C@H]1C[C@H](C=C(O1)C(=O)NCc2ccccc2F)c3coc4ccccc4c3=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 A20 compound treatment 166680.0 -184000.0 -0.92 196540.0 -198000.0 -0.93 -1.3093 -1.0 3189020 PK04_130018 C[C@@H](C=C)[C@H](O)c1ccc(OCCO)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 A21 compound treatment 168710.0 -182000.0 -0.91 123750.0 -271000.0 -1.27 -1.5443 -0.9864 2019329 PK04_130019 COC(=O)c1ccc(cc1)[C@@H]2C[C@H](OCCCCO)OC(=C2)C(=O)N3CCCCCCC3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 A22 compound treatment 377120.0 26300.0 0.13 187740.0 -207000.0 -0.97 -0.5954 -0.6063 3080190 PK04_130020 CO[C@@H](CCO)[C@@H](OC(=O)Nc1ccc(SC)cc1)c2ccc(OC)c(O)c2 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 A23 compound treatment 414620.0 63800.0 0.32 230780.0 -164000.0 -0.77 -0.3198 -0.3835 3221200 PK04_130021 OCCCCO[C@H]1C[C@H](C=C(O1)C(=O)N2CCCCCCC2)c3cccs3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 A24 compound treatment 307870.0 -43000.0 -0.21 202020.0 -193000.0 -0.91 -0.7925 -0.8511 3211695 PK04_130022 CO[C@@H](CCO)[C@@H](O)c1ccc(O)c(F)c1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 B01 compound treatment 317400.0 -33500.0 -0.17 499400.0 105000.0 0.49 0.2303 0.4425 3176327 PK04_130023 CN(C)CCCC[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3cccc(OCCO)c3)C(=O)OCCOc4ccc(cc4)[C@H]5N6[C@@H]([C@@H](C(=O)OCC=C)[C@]57C(=O)Nc8ccc(I)cc87)C(=O)O[C@@H]([C@@H]6c9ccccc9)c%10ccccc%10 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 B02 compound treatment 489410.0 139000.0 0.69 461650.0 67000.0 0.32 0.7122 0.9366 3221203 PK04_130024 C[C@@H]1[C@H]([C@H](CC(=O)N2Cc3ccccc3C[C@H]2CO)O[C@@]14C(=O)N(c5ccccc54)c6ccccc6)[Si](C)(C)F 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 B03 compound treatment 421470.0 70600.0 0.35 497780.0 103000.0 0.49 0.5924 0.9877 3052745 PK04_130025 NCCCC[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3cccc(OCCO)c3)C(=O)NCc4ccc(F)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 B04 compound treatment 478250.0 127000.0 0.64 467260.0 72600.0 0.34 0.6914 0.9575 3221205 PK04_130026 C[C@H]1[C@@H]([C@@H](CC(=O)N(CCO)Cc2ccccc2)O[C@]13C(=O)N(c4ccccc43)c5ccccc5)[Si](C)(C)F 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 B05 compound treatment 472500.0 122000.0 0.61 434170.0 39500.0 0.19 0.5611 0.8831 3176512 PK04_130027 CC(C)C[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3ccc(O)cc3)C(=O)OCCOc4ccc(cc4)[C@H]5N6[C@@H]([C@@H](C(=O)OCC=C)[C@]57C(=O)Nc8ccccc87)C(=O)O[C@@H]([C@@H]6c9ccccc9)c%10ccccc%10 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 B06 compound treatment 200870.0 -150000.0 -0.75 498960.0 104000.0 0.49 -0.1827 -0.2041 3221207 PK04_130028 C[C@@H]1[C@H]([C@H](CCO)O[C@@]12C(=O)N(C)c3ccccc32)[Si](C)(C)F 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 B07 compound treatment 428360.0 77500.0 0.39 290750.0 -104000.0 -0.49 -0.0718 -0.1152 3176123 PK04_130029 OCCOc1cccc(c1)[C@@H]2[C@@H](C[C@H]3N2C(=O)[C@H](Cc4ccccc4)NC3=O)C(=O)OCCOc5ccc(cc5)[C@H]6N7[C@@H]([C@@H](C(=O)OCC=C)[C@]68C(=O)Nc9ccccc98)C(=O)O[C@@H]([C@@H]7c%10ccccc%10)c%11ccccc%11 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 B08 compound treatment 492060.0 141000.0 0.71 509660.0 115000.0 0.54 0.8812 0.9914 3221209 PK04_130030 C[C@H]1[C@@H]([C@@H](CC(=O)N2CCC[C@H]2CO)O[C@]13C(=O)N(C)c4c3cc(C)cc4Br)[Si](C)(C)F 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 B09 compound treatment 471200.0 120000.0 0.6 529340.0 135000.0 0.63 0.873 0.9997 3052645 PK04_130031 CN(C)CCCCNC(=O)[C@@H]1C[C@H]2N([C@@H]1c3cccc(OCCO)c3)C(=O)CNC2=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 B10 compound treatment 409220.0 58400.0 0.29 276400.0 -118000.0 -0.56 -0.1871 -0.2981 3221211 PK04_130032 C[C@@H]1[C@H]([C@H](CCn2cc(nn2)[C@H](O)c3ccccc3)O[C@@]14C(=O)N(C)c5ccccc54)[Si](C)(C)F 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 B11 compound treatment 470570.0 120000.0 0.6 441130.0 46500.0 0.22 0.5774 0.907 3052831 PK04_130033 CN(C)CCCCNC(=O)[C@@H]1C[C@H]2N([C@@H]1c3ccc(O)cc3)C(=O)[C@@H]4CCCN4C2=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 B12 compound treatment 263050.0 -87800.0 -0.44 190950.0 -204000.0 -0.96 -0.9876 -0.9373 3221213 PK04_130034 C[C@H]1[C@@H]([C@@H](CC(=O)N2Cc3ccccc3C[C@H]2CO)O[C@]14C(=O)N(c5ccccc54)c6ccccc6)[Si](C)(C)F 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 B13 mock treatment 497780.0 147000.0 0.73 334830.0 -59800.0 -0.28 0.32 0.4071 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 B14 mock treatment 504540.0 154000.0 0.77 486250.0 91600.0 0.43 0.8474 0.9627 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 B15 compound treatment 479410.0 129000.0 0.64 499470.0 105000.0 0.49 0.8027 0.9915 3176778 PK04_130035 C[N+](C)(C)CCCC[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3ccc(O)cc3)C(=O)NCc4ccc(F)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 B16 compound treatment 464320.0 113000.0 0.57 440070.0 45400.0 0.21 0.5518 0.9111 3221214 PK04_130036 C[C@@H]1[C@H]([C@H](CCO)O[C@@]12C(=O)N(CC=C)c3ccccc32)[Si](C)(C)F 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 B17 compound treatment 467640.0 117000.0 0.58 390110.0 -4530.0 -0.02 0.3974 0.6808 3176195 PK04_130037 OCCOc1cccc(c1)[C@@H]2[C@@H](C[C@H]3N2C(=O)[C@@H]4CCCN4C3=O)C(=O)NCc5ccc(F)cc5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 B18 compound treatment 244980.0 -106000.0 -0.53 443900.0 49300.0 0.23 -0.2101 -0.3639 3221216 PK04_130038 C[C@H]1[C@@H]([C@@H](CCn2cc(CCO)nn2)O[C@]13C(=O)N(CC=C)c4ccccc43)[Si](C)(C)F 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 B19 compound treatment 435440.0 84600.0 0.42 416170.0 21500.0 0.1 0.3703 0.8525 3052584 PK04_130039 CN(C)CCCCCCNC(=O)[C@H]1C[C@@H]2N([C@H]1c3cccc(OCCO)c3)C(=O)[C@H](Cc4ccccc4)NC2=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 B20 compound treatment 424560.0 73700.0 0.37 362940.0 -31700.0 -0.15 0.1549 0.3899 3221218 PK04_130040 C[C@@H]1[C@H]([C@H](CC(=O)N2CCC[C@H]2CO)O[C@@]13C(=O)N(C)c4ccccc43)[Si](C)(C)F 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 B21 compound treatment 408760.0 57900.0 0.29 475750.0 81100.0 0.38 0.4743 0.9907 3176736 PK04_130041 CN(C)CCCC[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3ccc(O)cc3)C(=O)OCCOc4ccc(cc4)[C@H]5N6[C@@H]([C@@H](C(=O)OCC=C)[C@]57C(=O)Nc8ccccc87)C(=O)O[C@@H]([C@@H]6c9ccccc9)c%10ccccc%10 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 B22 compound treatment 290510.0 -60400.0 -0.3 191590.0 -203000.0 -0.96 -0.8885 -0.8871 3221220 PK04_130042 C[C@H]1[C@@H]([C@@H](CCO)O[C@]12C(=O)N(C)c3c2cc(C)cc3Br)[Si](C)(C)F 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 B23 compound treatment 422970.0 72100.0 0.36 477790.0 83200.0 0.39 0.5312 0.9992 3052927 PK04_130043 C[N+](C)(C)CCCC[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3ccc(O)cc3)C(=O)OCCOc4ccc(cc4)[C@H]5N6[C@@H]([C@@H](C(=O)OCC=C)[C@]57C(=O)Nc8ccccc87)C(=O)O[C@@H]([C@@H]6c9ccccc9)c%10ccccc%10 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 B24 compound treatment 346190.0 -4670.0 -0.02 397060.0 2420.0 0.01 -0.0084 -0.3248 3221222 PK04_130044 C[C@H]1[C@@H]([C@@H](CCn2cc(CCO)nn2)O[C@]13C(=O)N(c4ccccc43)c5ccccc5)[Si](C)(C)F 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 C01 compound treatment 343880.0 -6980.0 -0.03 320320.0 -74300.0 -0.35 -0.2718 -0.7738 3221224 PK04_130045 COC(=O)c1ccc(cc1)[C@@H]2C[C@H](OCCCCO)OC(=C2)C(=O)NCc3ccc(Cl)cc3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 C02 compound treatment 391540.0 40700.0 0.2 352980.0 -41700.0 -0.2 0.0051 0.0181 3211914 PK04_130046 COc1ccc(NC(=O)O[C@H]([C@H](C)CCO)c2ccc(O)c3ccccc23)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 C03 compound treatment 436720.0 85900.0 0.43 431130.0 36500.0 0.17 0.4246 0.9192 3221227 PK04_130047 OCCCCO[C@H]1C[C@H](C=C(O1)C(=O)N2CCOCCOCCOCCOCC2)c3cccs3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 C04 compound treatment 415860.0 65000.0 0.32 389280.0 -5360.0 -0.03 0.2117 0.6503 3211809 PK04_130048 CSc1ccc(NC(=O)O[C@@H]([C@H](C)CCO)c2ccc(OCCO)cc2)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 C05 compound treatment 183380.0 -167000.0 -0.84 256500.0 -138000.0 -0.65 -1.0509 -0.9922 2019446 PK04_130049 COC(CN(C)C(=O)C1=C[C@@H](C[C@H](OCCCCO)O1)c2coc3ccccc3c2=O)OC 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 C06 compound treatment 373280.0 22400.0 0.11 375690.0 -18900.0 -0.09 0.0162 0.1129 3069417 PK04_130050 C[C@H](C=C)[C@H](O)c1ccc(OCCO)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 C07 compound treatment 177600.0 -173000.0 -0.87 224000.0 -171000.0 -0.8 -1.1794 -0.9993 3221230 PK04_130051 COC(=O)c1ccc(cc1)[C@@H]2C[C@H](OCCCCO)OC(=C2)C(=O)Nc3ccc(O)cc3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 C08 compound treatment 251380.0 -99500.0 -0.5 187480.0 -207000.0 -0.97 -1.0403 -0.9512 3080227 PK04_130052 CSc1ccc(NC(=O)O[C@H]([C@H](C)CCO)c2ccc(OCCO)cc2)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 C09 compound treatment 389450.0 38600.0 0.19 418490.0 23900.0 0.11 0.2156 0.9669 3221232 PK04_130053 OCCCCO[C@H]1C[C@H](C=C(O1)C(=O)O)c2cccs2 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 C10 compound treatment 271760.0 -79100.0 -0.4 404160.0 9520.0 0.04 -0.2477 -0.6229 3080226 PK04_130054 COc1ccc(NC(=O)O[C@@H]([C@@H](C)CCO)c2ccc(OCCO)cc2)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 C11 mock treatment 374130.0 23300.0 0.12 427210.0 32600.0 0.15 0.1905 0.9907 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 C12 mock treatment 322100.0 -28800.0 -0.14 433510.0 38900.0 0.18 0.0277 0.1192 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 C13 compound treatment 433060.0 82200.0 0.41 221330.0 -173000.0 -0.82 -0.2861 -0.3135 3221235 PK04_130055 Cn1c(cc(=O)n1c2ccccc2)[C@@H]3C[C@H](OCCCCO)OC(=C3)C(=O)NCCCCCCO 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 C14 compound treatment 210080.0 -141000.0 -0.7 160210.0 -234000.0 -1.1 -1.2769 -0.9764 3080272 PK04_130056 OCCC[C@H](O)c1ccc(O)c2ccccc12 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 C15 mock treatment 256610.0 -94300.0 -0.47 440830.0 46200.0 0.22 -0.1792 -0.3457 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 C16 mock treatment 403360.0 52500.0 0.26 327200.0 -67400.0 -0.32 -0.0389 -0.0945 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 C17 compound treatment 246880.0 -104000.0 -0.52 343200.0 -51400.0 -0.24 -0.5383 -0.9396 3221238 PK04_130057 Cn1c(cc(=O)n1c2ccccc2)[C@@H]3C[C@H](OCCCCO)OC(=C3)C(=O)Nc4ccc(O)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 C18 compound treatment 128120.0 -223000.0 -1.11 194460.0 -200000.0 -0.94 -1.4524 -0.9966 3080228 PK04_130058 OCCC[C@@H](O)c1ccc(O)c2ccccc12 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 C19 compound treatment 189160.0 -162000.0 -0.81 194720.0 -200000.0 -0.94 -1.236 -0.9971 2019457 PK04_130059 Nc1ccccc1NC(=O)C2=C[C@@H](C[C@H](OCCCCO)O2)c3coc4ccccc4c3=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 C20 compound treatment 299100.0 -51800.0 -0.26 325300.0 -69300.0 -0.33 -0.4134 -0.9934 3080205 PK04_130060 OCCC[C@@H](O)c1ccc(O)c(F)c1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 C21 compound treatment 253510.0 -97400.0 -0.49 257220.0 -137000.0 -0.65 -0.8009 -0.9902 3221241 PK04_130061 OCCCCO[C@H]1C[C@H](C=C(O1)C(=O)N[C@@H]2[C@H](O)Cc3ccccc23)c4cccs4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 C22 compound treatment 238090.0 -113000.0 -0.56 356100.0 -38500.0 -0.18 -0.5264 -0.8897 3211908 PK04_130062 COc1ccc(NC(=O)O[C@@H]([C@H](C)CCO)c2ccc(O)c3ccccc23)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 C23 compound treatment 262850.0 -88000.0 -0.44 268690.0 -126000.0 -0.59 -0.7297 -0.9892 2019323 PK04_130063 COC(=O)c1ccc(cc1)[C@@H]2C[C@H](OCCCCO)OC(=C2)C(=O)Nc3ccccc3O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 C24 compound treatment 298930.0 -51900.0 -0.26 344530.0 -50100.0 -0.24 -0.3501 -0.9989 3211812 PK04_130064 C[C@@H](CCO)[C@H](O)c1ccc(OCCO)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 D01 compound treatment 257730.0 -93100.0 -0.47 459300.0 64700.0 0.3 -0.1138 -0.2048 3175965 PK04_130065 CC(=O)NCCCC[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3cccc(OCCO)c3)C(=O)OCCOc4ccc(cc4)[C@H]5N6[C@@H]([C@@H](C(=O)OCC=C)[C@]57C(=O)Nc8ccc(I)cc87)C(=O)O[C@@H]([C@@H]6c9ccccc9)c%10ccccc%10 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 D02 compound treatment 472800.0 122000.0 0.61 445760.0 51100.0 0.24 0.6007 0.9174 3221243 PK04_130066 COc1cc2c3N(C(=O)[C@@]42O[C@H](CCO)[C@H]([C@@H]4C)[Si](C)(C)F)C(C)(C)C=C(C)c3c1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 D03 compound treatment 462410.0 112000.0 0.56 456360.0 61700.0 0.29 0.5992 0.9538 3176379 PK04_130067 NCCCC[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3cccc(OCCO)c3)C(=O)O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 D04 compound treatment 179940.0 -171000.0 -0.85 197350.0 -197000.0 -0.93 -1.2598 -0.9991 3221245 PK04_130068 C[C@H]1[C@@H]([C@@H](CCO)O[C@]12C(=O)N(C)c3ccccc32)[Si](C)(C)F 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 D05 compound treatment 206030.0 -145000.0 -0.72 382690.0 -11900.0 -0.06 -0.5512 -0.7597 3052839 PK04_130069 Oc1ccc(cc1)[C@@H]2[C@@H](C[C@H]3N2C(=O)[C@@H]4CCCN4C3=O)C(=O)OCCOc5ccc(cc5)[C@H]6N7[C@@H]([C@@H](C(=O)OCC=C)[C@]68C(=O)Nc9ccccc98)C(=O)O[C@@H]([C@@H]7c%10ccccc%10)c%11ccccc%11 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 D06 compound treatment 383210.0 32300.0 0.16 374350.0 -20300.0 -0.1 0.0468 0.2493 3221246 PK04_130070 C[C@@H]1[C@H]([C@H](CC(=O)N2Cc3ccccc3C[C@H]2CO)O[C@@]14C(=O)N(C)c5c4cc(C)cc5Br)[Si](C)(C)F 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 D07 compound treatment 301670.0 -49200.0 -0.25 387060.0 -7580.0 -0.04 -0.1989 -0.8013 3176048 PK04_130071 CC(C)C[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3cccc(OCCO)c3)C(=O)OCCOc4ccc(cc4)[C@H]5N6[C@@H]([C@@H](C(=O)OCC=C)[C@]57C(=O)Nc8ccccc87)C(=O)O[C@@H]([C@@H]6c9ccccc9)c%10ccccc%10 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 D08 compound treatment 481540.0 131000.0 0.65 503090.0 108000.0 0.51 0.8222 0.9926 3221248 PK04_130072 C[C@@H]1[C@H]([C@H](CC(=O)N2CCC[C@H]2CO)O[C@@]13C(=O)N(c4ccccc43)c5ccccc5)[Si](C)(C)F 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 D09 compound treatment 431040.0 80200.0 0.4 425680.0 31000.0 0.15 0.3864 0.9066 3175970 PK04_130073 CC(C)C[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3cccc(OCCO)c3)C(=O)NCCCCN(C)C 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 D10 compound treatment 209600.0 -141000.0 -0.71 482720.0 88100.0 0.41 -0.2059 -0.2517 3221250 PK04_130074 C[C@H]1[C@@H]([C@@H](CC(=O)N2CCC[C@H]2CO)O[C@]13C(=O)N(c4ccccc43)c5ccccc5)[Si](C)(C)F 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 D11 mock treatment 451490.0 101000.0 0.5 506950.0 112000.0 0.53 0.7289 0.9997 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 D12 mock treatment 421370.0 70500.0 0.35 475360.0 80700.0 0.38 0.5175 0.9993 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 D13 compound treatment 365760.0 14900.0 0.07 483390.0 88800.0 0.42 0.3478 0.8202 3176675 PK04_130075 Oc1ccc(cc1)[C@@H]2[C@@H](C[C@H]3N2C(=O)CNC3=O)C(=O)NCc4ccc(F)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 D14 compound treatment 286320.0 -64500.0 -0.32 363960.0 -30700.0 -0.14 -0.33 -0.9343 3221251 PK04_130076 C[C@@H]1[C@H]([C@H](CC(=O)N2Cc3ccccc3C[C@H]2CO)O[C@@]14C(=O)N(C)c5ccccc54)[Si](C)(C)F 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 D15 mock treatment 401070.0 50200.0 0.25 511000.0 116000.0 0.55 0.5643 0.9374 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 D16 mock treatment 431520.0 80700.0 0.4 468720.0 74100.0 0.35 0.5313 0.9974 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 D17 compound treatment 328430.0 -22400.0 -0.11 342080.0 -52600.0 -0.25 -0.254 -0.9359 3052531 PK04_130077 CC(=O)NCCCC[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3cccc(OCCO)c3)C(=O)NCc4ccc(F)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 D18 compound treatment 361770.0 10900.0 0.05 338560.0 -56100.0 -0.26 -0.148 -0.5494 3221253 PK04_130078 C[C@H]1[C@@H]([C@@H](CCn2cc(CCO)nn2)O[C@]13C(=O)N(C)c4ccccc43)[Si](C)(C)F 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 D19 compound treatment 396960.0 46100.0 0.23 347110.0 -47500.0 -0.22 0.0047 0.0148 3052793 PK04_130079 CN(C)CCCCCCNC(=O)[C@H]1C[C@@H]2N([C@H]1c3ccc(O)cc3)C(=O)[C@H](Cc4ccccc4)NC2=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 D20 compound treatment 354520.0 3660.0 0.02 318100.0 -76500.0 -0.36 -0.2416 -0.6703 3221255 PK04_130080 C[C@H]1[C@@H]([C@@H](CCn2cc(nn2)[C@H](O)c3ccccc3)O[C@]14C(=O)N(C)c5ccccc54)[Si](C)(C)F 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 D21 compound treatment 395880.0 45000.0 0.22 316240.0 -78400.0 -0.37 -0.1018 -0.2356 3052828 PK04_130081 Oc1ccc(cc1)[C@H]2[C@H](C[C@@H]3N2C(=O)[C@H](Cc4ccccc4)NC3=O)C(=O)OCCOc5ccc(cc5)[C@H]6N7[C@@H]([C@@H](C(=O)OCC=C)[C@]68C(=O)Nc9ccccc98)C(=O)O[C@@H]([C@@H]7c%10ccccc%10)c%11ccccc%11 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 D22 compound treatment 324640.0 -26200.0 -0.13 289250.0 -105000.0 -0.5 -0.4431 -0.8643 3221256 PK04_130082 C[C@@H]1[C@H]([C@H](CCn2cc(CCO)nn2)O[C@@]13C(=O)N(c4ccccc43)c5ccccc5)[Si](C)(C)F 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 D23 compound treatment 261530.0 -89300.0 -0.45 391560.0 -3080.0 -0.01 -0.3257 -0.7297 3052592 PK04_130083 OCCOc1cccc(c1)[C@H]2[C@H](C[C@@H]3N2C(=O)[C@H](Cc4ccccc4)NC3=O)C(=O)OCCOc5ccc(cc5)[C@H]6N7[C@@H]([C@@H](C(=O)OCC=C)[C@]68C(=O)Nc9ccccc98)C(=O)O[C@@H]([C@@H]7c%10ccccc%10)c%11ccccc%11 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 D24 compound treatment 407960.0 57100.0 0.29 384030.0 -10600.0 -0.05 0.1664 0.5747 3221257 PK04_130084 C[C@@H]1[C@H]([C@H](CCO)O[C@@]12C(=O)N(C)c3c2cc(C)cc3Br)[Si](C)(C)F 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 E01 mock treatment 522200.0 171000.0 0.86 509950.0 115000.0 0.54 0.9886 0.9758 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 E02 mock treatment 443210.0 92300.0 0.46 468590.0 74000.0 0.35 0.5721 0.9903 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 E03 compound treatment 199250.0 -152000.0 -0.76 451310.0 56700.0 0.27 -0.3469 -0.4322 2019322 PK04_130085 COC(=O)c1ccc(cc1)[C@@H]2C[C@H](OCCCCO)OC(=C2)C(=O)Nc3ccccc3N 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 E04 compound treatment 413280.0 62400.0 0.31 214420.0 -180000.0 -0.85 -0.379 -0.4196 3080210 PK04_130086 CO[C@@H](CCO)[C@@H](OC(=O)Nc1ccc(OC)cc1)c2ccc(O)c(F)c2 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 E05 compound treatment 373310.0 22400.0 0.11 414180.0 19500.0 0.09 0.1443 0.9951 3221259 PK04_130087 OCCCCCCNC(=O)C1=C[C@@H](C[C@H](OCCCCO)O1)c2cccs2 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 E06 compound treatment 192710.0 -158000.0 -0.79 472490.0 77900.0 0.37 -0.2996 -0.3441 3211802 PK04_130088 OCCC[C@H](O)c1ccc(OCCO)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 E07 compound treatment 396610.0 45700.0 0.23 384800.0 -9840.0 -0.05 0.1289 0.5527 3221261 PK04_130089 Cn1c(cc(=O)n1c2ccccc2)[C@@H]3C[C@H](OCCCCO)OC(=C3)C(=O)NCc4ccc(Cl)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 E08 compound treatment 487090.0 136000.0 0.68 471600.0 77000.0 0.36 0.7371 0.9564 3080219 PK04_130090 COc1ccc(NC(=O)O[C@H](CCCO)c2ccc(OCCO)cc2)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 E09 mock treatment 333280.0 -17600.0 -0.09 247040.0 -148000.0 -0.69 -0.553 -0.7902 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 E10 mock treatment 428480.0 77600.0 0.39 473340.0 78700.0 0.37 0.5359 0.9997 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 E11 compound treatment 477210.0 126000.0 0.63 488270.0 93600.0 0.44 0.7576 0.9845 3221264 PK04_130091 COC(CN(C)C(=O)C1=C[C@@H](C[C@H](OCCCCO)O1)c2cc(=O)n(c3ccccc3)n2C)OC 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 E12 compound treatment 411960.0 61100.0 0.31 304860.0 -89800.0 -0.42 -0.0828 -0.1589 3069920 PK04_130092 O[C@@H](CC=C)c1ccc(O)c(F)c1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 E13 compound treatment 293280.0 -57600.0 -0.29 467040.0 72400.0 0.34 0.0375 0.084 3221266 PK04_130093 Cn1c(cc(=O)n1c2ccccc2)[C@@H]3C[C@H](OCCCCO)OC(=C3)C(=O)Nc4ccccc4N 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 E14 compound treatment 440990.0 90100.0 0.45 279040.0 -116000.0 -0.54 -0.0662 -0.0937 3211678 PK04_130094 CO[C@H](CCO)[C@H](OC(=O)Nc1ccc(OC)cc1)c2ccc(OC)c(O)c2 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 E15 compound treatment 444850.0 94000.0 0.47 254040.0 -141000.0 -0.66 -0.1357 -0.1673 3221269 PK04_130095 Cn1c(cc(=O)n1c2ccccc2)[C@@H]3C[C@H](OCCCCO)OC(=C3)C(=O)N4CCOCCOCCOCCOCC4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 E16 compound treatment 278480.0 -72400.0 -0.36 303140.0 -91500.0 -0.43 -0.5599 -0.9962 3211906 PK04_130096 CSc1ccc(NC(=O)O[C@@H]([C@H](C)C=C)c2ccc(O)c3ccccc23)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 E17 mock treatment 368730.0 17900.0 0.09 462170.0 67500.0 0.32 0.2877 0.872 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 E18 mock treatment 446340.0 95500.0 0.48 339860.0 -54800.0 -0.26 0.155 0.286 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 E19 compound treatment 383160.0 32300.0 0.16 313730.0 -80900.0 -0.38 -0.155 -0.3751 2019458 PK04_130097 OCCCCO[C@H]1C[C@H](C=C(O1)C(=O)Nc2ccccc2O)c3coc4ccccc4c3=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 E20 compound treatment 355250.0 4390.0 0.02 315150.0 -79500.0 -0.37 -0.2489 -0.6645 3211804 PK04_130098 COc1ccc(NC(=O)O[C@@H](CCCO)c2ccc(OCCO)cc2)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 E21 compound treatment 285640.0 -65200.0 -0.33 285190.0 -109000.0 -0.51 -0.5944 -0.9756 3221271 PK04_130099 OCCCCO[C@H]1C[C@H](C=C(O1)C(=O)NCc2ccccc2F)c3cccs3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 E22 compound treatment 388070.0 37200.0 0.19 421500.0 26900.0 0.13 0.2208 0.9823 3211680 PK04_130100 CO[C@@H](CCO)[C@@H](OC(=O)Nc1ccc(OC)cc1)c2ccc(OC)c(O)c2 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 E23 compound treatment 255730.0 -95100.0 -0.48 243040.0 -152000.0 -0.71 -0.8402 -0.9805 2019464 PK04_130101 OCCCCO[C@H]1C[C@H](C=C(O1)C(=O)N2CCCCCCC2)c3coc4ccccc4c3=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 E24 compound treatment 348280.0 -2580.0 -0.01 314210.0 -80400.0 -0.38 -0.2766 -0.7308 3211909 PK04_130102 CSc1ccc(NC(=O)O[C@H]([C@@H](C)CCO)c2ccc(O)c3ccccc23)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 F01 mock treatment 494880.0 144000.0 0.72 454520.0 59900.0 0.28 0.7078 0.9163 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 F02 mock treatment 465450.0 115000.0 0.57 464250.0 69600.0 0.33 0.6362 0.9649 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 F03 compound treatment 495810.0 145000.0 0.72 482350.0 87700.0 0.41 0.8036 0.9645 3176785 PK04_130103 NCCCC[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3ccc(O)cc3)C(=O)O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 F04 compound treatment 447460.0 96600.0 0.48 440160.0 45500.0 0.21 0.4926 0.9332 3221273 PK04_130104 C[C@H]1[C@@H]([C@@H](CC(=O)N2Cc3ccccc3C[C@H]2CO)O[C@]14C(=O)N(C)c5c4cc(C)cc5Br)[Si](C)(C)F 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 F05 compound treatment 194320.0 -157000.0 -0.78 225690.0 -169000.0 -0.79 -1.1148 -1.0 3176500 PK04_130105 CC(=O)NCCCC[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3ccc(O)cc3)C(=O)OCCOc4ccc(cc4)[C@H]5N6[C@@H]([C@@H](C(=O)OCC=C)[C@]57C(=O)Nc8ccccc87)C(=O)O[C@@H]([C@@H]6c9ccccc9)c%10ccccc%10 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 F06 compound treatment 367470.0 16600.0 0.08 312280.0 -82400.0 -0.39 -0.2153 -0.5434 3221274 PK04_130106 C[C@@H]1[C@H]([C@H](CCn2cc(CCO)nn2)O[C@@]13C(=O)N(CC=C)c4ccccc43)[Si](C)(C)F 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 F07 compound treatment 481290.0 130000.0 0.65 254450.0 -140000.0 -0.66 -0.0056 -0.0061 3052886 PK04_130107 CN(C)CCCC[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3ccc(O)cc3)C(=O)OCCOc4ccc(cc4)[C@H]5N6[C@@H]([C@@H](C(=O)OCC=C)[C@]57C(=O)Nc8ccccc87)C(=O)O[C@@H]([C@@H]6c9ccccc9)c%10ccccc%10 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 F08 compound treatment 493030.0 142000.0 0.71 483410.0 88800.0 0.42 0.7974 0.968 3221275 PK04_130108 C[C@@H]1[C@H]([C@H](CCO)O[C@@]12C(=O)N(c3ccccc32)c4ccccc4)[Si](C)(C)F 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 F09 mock treatment 452720.0 102000.0 0.51 449360.0 54700.0 0.26 0.5417 0.9502 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 F10 mock treatment 438440.0 87600.0 0.44 247080.0 -148000.0 -0.69 -0.1815 -0.2212 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 F11 compound treatment 200640.0 -150000.0 -0.75 423460.0 28800.0 0.14 -0.4347 -0.5701 3052654 PK04_130109 CN(C)CCCCNC(=O)[C@@H]1C[C@H]2N([C@@H]1c3cccc(OCCO)c3)C(=O)[C@H](CCCCN(C)C)NC2=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 F12 compound treatment 492160.0 141000.0 0.71 233920.0 -161000.0 -0.76 -0.0355 -0.0343 3221277 PK04_130110 C[C@H]1[C@@H]([C@@H](CC(=O)N(CCO)Cc2ccccc2)O[C@]13C(=O)N(C)c4ccccc43)[Si](C)(C)F 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 F13 compound treatment 460960.0 110000.0 0.55 509570.0 115000.0 0.54 0.7711 1.0 3052647 PK04_130111 OCCOc1cccc(c1)[C@@H]2[C@@H](C[C@H]3N2C(=O)CNC3=O)C(=O)NCc4ccc(F)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 F14 compound treatment 219770.0 -131000.0 -0.65 325850.0 -68800.0 -0.32 -0.6917 -0.9472 3221279 PK04_130112 C[C@H]1[C@@H]([C@@H](CC(=O)N2Cc3ccccc3C[C@H]2CO)O[C@]14C(=O)N(C)c5ccccc54)[Si](C)(C)F 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 F15 compound treatment 257140.0 -93700.0 -0.47 310460.0 -84200.0 -0.4 -0.611 -0.9965 3176113 PK04_130113 OCCOc1cccc(c1)[C@@H]2[C@@H](C[C@H]3N2C(=O)[C@H](Cc4ccccc4)NC3=O)C(=O)NCc5ccc(F)cc5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 F16 compound treatment 269510.0 -81400.0 -0.41 247130.0 -148000.0 -0.69 -0.7779 -0.9675 3221280 PK04_130114 C[C@H]1[C@@H]([C@@H](CCn2cc(nn2)[C@H](O)c3ccccc3)O[C@]14C(=O)N(CC=C)c5ccccc54)[Si](C)(C)F 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 F17 mock treatment 262480.0 -88400.0 -0.44 466670.0 72000.0 0.34 -0.0725 -0.1304 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 F18 mock treatment 430600.0 79700.0 0.4 477700.0 83100.0 0.39 0.5579 1.0 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 F19 compound treatment 208170.0 -143000.0 -0.71 202090.0 -193000.0 -0.91 -1.1443 -0.993 3052888 PK04_130115 CN(C)CCCCCCNC(=O)[C@H]1C[C@@H]2N([C@H]1c3ccc(O)cc3)C(=O)[C@H](CCCC[N+](C)(C)C)NC2=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 F20 compound treatment 246050.0 -105000.0 -0.52 184160.0 -210000.0 -0.99 -1.0702 -0.9556 3221282 PK04_130116 C[C@H]1[C@@H]([C@@H](CCO)O[C@]12C(=O)N(c3ccccc32)c4ccccc4)[Si](C)(C)F 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 F21 compound treatment 276290.0 -74600.0 -0.37 298720.0 -95900.0 -0.45 -0.5824 -0.9955 3176499 PK04_130117 CC(=O)NCCCC[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3ccc(O)cc3)C(=O)OCCOc4ccc(cc4)[C@H]5N6[C@@H]([C@@H](C(=O)OCC=C)[C@]57C(=O)Nc8ccccc87)C(=O)O[C@@H]([C@@H]6c9ccccc9)c%10ccccc%10 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 F22 compound treatment 335360.0 -15500.0 -0.08 262080.0 -133000.0 -0.62 -0.4956 -0.7889 3221283 PK04_130118 C[C@@H]1[C@H]([C@H](CC(=O)N(CCO)Cc2ccccc2)O[C@@]13C(=O)N(C)c4ccccc43)[Si](C)(C)F 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 F23 compound treatment 278640.0 -72200.0 -0.36 290560.0 -104000.0 -0.49 -0.6012 -0.9887 3175968 PK04_130119 CC(=O)NCCCC[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3cccc(OCCO)c3)C(=O)OCCOc4ccc(cc4)[C@H]5N6[C@@H]([C@@H](C(=O)OCC=C)[C@]57C(=O)Nc8ccccc87)C(=O)O[C@@H]([C@@H]6c9ccccc9)c%10ccccc%10 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 F24 compound treatment 322880.0 -28000.0 -0.14 284640.0 -110000.0 -0.52 -0.4647 -0.867 3221284 PK04_130120 C[C@@H]1[C@H]([C@H](CC(=O)N2CCC[C@H]2CO)O[C@@]13C(=O)N(C)c4c3cc(C)cc4Br)[Si](C)(C)F 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 G01 compound treatment 433490.0 82600.0 0.41 427610.0 33000.0 0.16 0.4015 0.9107 2019328 PK04_130121 COC(=O)c1ccc(cc1)[C@@H]2C[C@H](OCCCCO)OC(=C2)C(=O)N3CCOCCOCCOCCOCC3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 G02 compound treatment 239230.0 -112000.0 -0.56 236110.0 -159000.0 -0.75 -0.9215 -0.9897 3211907 PK04_130122 COc1ccc(NC(=O)O[C@@H]([C@H](C)C=C)c2ccc(O)c3ccccc23)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 G03 mock treatment 454880.0 104000.0 0.52 457180.0 62500.0 0.29 0.5754 0.9637 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 G04 mock treatment 208490.0 -142000.0 -0.71 480530.0 85900.0 0.4 -0.2171 -0.2655 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 G05 compound treatment 416740.0 65900.0 0.33 195320.0 -199000.0 -0.94 -0.4303 -0.433 3221285 PK04_130123 COC(=O)c1ccc(cc1)[C@@H]2C[C@H](OCCCCO)OC(=C2)C(=O)NCCCCCCO 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 G06 compound treatment 427370.0 76500.0 0.38 410500.0 15900.0 0.07 0.323 0.8295 3211815 PK04_130124 COc1ccc(NC(=O)O[C@H]([C@H](C)C=C)c2ccc(OCCO)cc2)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 G07 compound treatment 441330.0 90500.0 0.45 385670.0 -8970.0 -0.04 0.2897 0.6383 3221287 PK04_130125 COC(=O)c1ccc(cc1)[C@@H]2C[C@H](OCCCCO)OC(=C2)C(=O)NCc3ccccc3F 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 G08 compound treatment 395620.0 44800.0 0.22 316120.0 -78500.0 -0.37 -0.1031 -0.2388 3211803 PK04_130126 CSc1ccc(NC(=O)O[C@@H](CCCO)c2ccc(OCCO)cc2)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 G09 compound treatment 271780.0 -79100.0 -0.39 355540.0 -39100.0 -0.18 -0.4093 -0.9395 3221289 PK04_130127 Cn1c(cc(=O)n1c2ccccc2)[C@@H]3C[C@H](OCCCCO)OC(=C3)C(=O)N4CCCCCCC4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 G10 compound treatment 335410.0 -15500.0 -0.08 207940.0 -187000.0 -0.88 -0.6755 -0.7663 3211807 PK04_130128 CO[C@@H](CCO)[C@@H](OC(=O)Nc1ccc(SC)cc1)c2ccc(OCCO)cc2 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 G11 compound treatment 206320.0 -145000.0 -0.72 435530.0 40900.0 0.19 -0.3745 -0.5012 2019311 PK04_130129 COC(CN(C)C(=O)C1=C[C@@H](C[C@H](OCCCCO)O1)c2ccc(cc2)C(=O)OC)OC 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 G12 compound treatment 371520.0 20700.0 0.1 255600.0 -139000.0 -0.65 -0.3895 -0.5883 3211818 PK04_130130 COc1ccc(NC(=O)O[C@H](CCCO)c2ccc(O)c3ccccc23)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 G13 compound treatment 201330.0 -150000.0 -0.75 192180.0 -202000.0 -0.95 -1.2015 -0.9928 3221292 PK04_130131 Cn1c(cc(=O)n1c2ccccc2)[C@@H]3C[C@H](OCCCCO)OC(=C3)C(=O)Nc4ccccc4O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 G14 compound treatment 503750.0 153000.0 0.76 234150.0 -160000.0 -0.75 0.0062 0.0058 3080207 PK04_130132 OCCC[C@H](O)c1ccc(O)c(F)c1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 G15 compound treatment 275360.0 -75500.0 -0.38 492720.0 98100.0 0.46 0.0596 0.1 2019470 PK04_130133 OCCCCO[C@H]1C[C@H](C=C(O1)C(=O)O)c2coc3ccccc3c2=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 G16 compound treatment 228900.0 -122000.0 -0.61 343040.0 -51600.0 -0.24 -0.6023 -0.9186 3080225 PK04_130134 COc1ccc(NC(=O)O[C@H]([C@@H](C)CCO)c2ccc(OCCO)cc2)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 G17 compound treatment 196710.0 -154000.0 -0.77 211200.0 -183000.0 -0.86 -1.1545 -0.9984 3221294 PK04_130135 OCCCCO[C@H]1C[C@H](C=C(O1)C(=O)N[C@@H]2[C@H](O)Cc3ccccc23)c4coc5ccccc5c4=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 G18 compound treatment 485800.0 135000.0 0.67 205570.0 -189000.0 -0.89 -0.1523 -0.1365 3211806 PK04_130136 CO[C@@H](CCO)[C@@H](O)c1ccc(OCCO)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 G19 mock treatment 343390.0 -7470.0 -0.04 314720.0 -79900.0 -0.38 -0.2922 -0.7735 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 G20 mock treatment 253280.0 -97600.0 -0.49 298690.0 -95900.0 -0.45 -0.6637 -0.9993 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 G21 compound treatment 225710.0 -125000.0 -0.63 349920.0 -44700.0 -0.21 -0.5907 -0.8957 2019463 PK04_130137 OCCCCO[C@H]1C[C@H](C=C(O1)C(=O)N2CCOCCOCCOCCOCC2)c3coc4ccccc4c3=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 G22 compound treatment 247800.0 -103000.0 -0.51 189510.0 -205000.0 -0.96 -1.0462 -0.9567 3080280 PK04_130138 COc1ccc(NC(=O)O[C@H]([C@@H](C)CCO)c2ccc(O)c3ccccc23)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 G23 compound treatment 386410.0 35500.0 0.18 414640.0 20000.0 0.09 0.1921 0.9559 3221297 PK04_130139 Cn1c(cc(=O)n1c2ccccc2)[C@@H]3C[C@H](OCCCCO)OC(=C3)C(=O)O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 G24 compound treatment 261210.0 -89700.0 -0.45 167880.0 -227000.0 -1.07 -1.0708 -0.9257 3211912 PK04_130140 C[C@H](CCO)[C@@H](O)c1ccc(O)c2ccccc12 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 H01 compound treatment 253140.0 -97700.0 -0.49 210660.0 -184000.0 -0.87 -0.957 -0.9633 3052931 PK04_130141 NCCCC[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3ccc(O)cc3)C(=O)NCc4ccc(F)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 H02 compound treatment 185280.0 -166000.0 -0.83 244440.0 -150000.0 -0.71 -1.0843 -0.9969 3221300 PK04_130142 C[C@@H]1[C@H]([C@H](CCn2cc(CCO)nn2)O[C@@]13C(=O)N(C)c4ccccc43)[Si](C)(C)F 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 H03 mock treatment 518270.0 167000.0 0.84 469120.0 74500.0 0.35 0.839 0.9254 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 H04 mock treatment 513120.0 162000.0 0.81 215520.0 -179000.0 -0.84 -0.0227 -0.0194 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 H05 compound treatment 239400.0 -111000.0 -0.56 445280.0 50600.0 0.24 -0.2252 -0.3719 3176330 PK04_130143 CN(C)CCCC[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3cccc(OCCO)c3)C(=O)OCCOc4ccc(cc4)[C@H]5N6[C@@H]([C@@H](C(=O)OCC=C)[C@]57C(=O)Nc8ccccc87)C(=O)O[C@@H]([C@@H]6c9ccccc9)c%10ccccc%10 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 H06 compound treatment 438880.0 88000.0 0.44 185360.0 -209000.0 -0.98 -0.3852 -0.3573 3221301 PK04_130144 C[C@@H]1[C@H]([C@H](CC(=O)N(CCO)Cc2ccccc2)O[C@@]13C(=O)N(c4ccccc43)c5ccccc5)[Si](C)(C)F 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 H07 compound treatment 149770.0 -201000.0 -1.0 227240.0 -167000.0 -0.79 -1.2669 -0.9927 3176685 PK04_130145 Oc1ccc(cc1)[C@@H]2[C@@H](C[C@H]3N2C(=O)CNC3=O)C(=O)OCCOc4ccc(cc4)[C@H]5N6[C@@H]([C@@H](C(=O)OCC=C)[C@]57C(=O)Nc8ccccc87)C(=O)O[C@@H]([C@@H]6c9ccccc9)c%10ccccc%10 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 H08 compound treatment 484810.0 134000.0 0.67 490430.0 95800.0 0.45 0.7917 0.9815 3221302 PK04_130146 C[C@H]1[C@@H]([C@@H](CC(=O)N2CCC[C@H]2CO)O[C@]13C(=O)N(C)c4ccccc43)[Si](C)(C)F 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 H09 compound treatment 208110.0 -143000.0 -0.71 229010.0 -166000.0 -0.78 -1.055 -0.999 3052879 PK04_130147 CN(C)CCCCNC(=O)[C@@H]1C[C@H]2N([C@@H]1c3ccc(O)cc3)C(=O)[C@H](CCCCN(C)C)NC2=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 H10 compound treatment 218720.0 -132000.0 -0.66 230260.0 -164000.0 -0.77 -1.0134 -0.9969 3221303 PK04_130148 C[C@H]1[C@@H]([C@@H](CC(=O)N(CCO)Cc2ccccc2)O[C@]13C(=O)N(C)c4c3cc(C)cc4Br)[Si](C)(C)F 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 H11 compound treatment 306290.0 -44600.0 -0.22 526210.0 132000.0 0.62 0.2802 0.426 3176775 PK04_130149 CN(C)CCCCNC(=O)[C@@H]1C[C@H]2N([C@@H]1c3ccc(O)cc3)C(=O)[C@H](CCCC[N+](C)(C)C)NC2=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 H12 compound treatment 185250.0 -166000.0 -0.83 175270.0 -219000.0 -1.03 -1.3145 -0.994 3221305 PK04_130150 COc1cc2c3N(C(=O)[C@]42O[C@@H](CCO)[C@@H]([C@H]4C)[Si](C)(C)O)C(C)(C)C=C(C)c3c1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 H13 compound treatment 416810.0 65900.0 0.33 300320.0 -94300.0 -0.44 -0.0808 -0.1462 3052783 PK04_130151 CC(C)C[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3ccc(O)cc3)C(=O)NCc4ccc(F)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 H14 compound treatment 301380.0 -49500.0 -0.25 286310.0 -108000.0 -0.51 -0.535 -0.9448 3221307 PK04_130152 C[C@@H]1[C@H]([C@H](CCn2cc(nn2)[C@H](O)c3ccccc3)O[C@@]14C(=O)N(CC=C)c5ccccc54)[Si](C)(C)F 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 H15 compound treatment 478790.0 128000.0 0.64 242560.0 -152000.0 -0.72 -0.054 -0.0563 3176626 PK04_130153 Oc1ccc(cc1)[C@@H]2[C@@H](C[C@H]3N2C(=O)[C@@H]4CCCN4C3=O)C(=O)NCc5ccc(F)cc5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 H16 compound treatment 184640.0 -166000.0 -0.83 239650.0 -155000.0 -0.73 -1.1025 -0.9979 3221308 PK04_130154 C[C@H]1[C@@H]([C@@H](CCO)O[C@]12C(=O)N(CC=C)c3ccccc32)[Si](C)(C)F 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 H17 compound treatment 182680.0 -168000.0 -0.84 404580.0 9940.0 0.05 -0.5609 -0.6667 3176501 PK04_130155 CC(C)C[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3ccc(O)cc3)C(=O)NCCCCCCN(C)C 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 H18 compound treatment 215060.0 -136000.0 -0.68 240230.0 -154000.0 -0.73 -0.9932 -0.9994 3221309 PK04_130156 C[C@@H]1[C@H]([C@H](CC(=O)N(CCO)Cc2ccccc2)O[C@@]13C(=O)N(C)c4c3cc(C)cc4Br)[Si](C)(C)F 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 H19 mock treatment 224480.0 -126000.0 -0.63 409810.0 15200.0 0.07 -0.3959 -0.6232 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 H20 mock treatment 296260.0 -54600.0 -0.27 445410.0 50800.0 0.24 -0.024 -0.0661 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 H21 compound treatment 328280.0 -22600.0 -0.11 365520.0 -29100.0 -0.14 -0.1766 -0.9953 3052741 PK04_130157 C[N+](C)(C)CCCC[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3cccc(OCCO)c3)C(=O)OCCOc4ccc(cc4)[C@H]5N6[C@@H]([C@@H](C(=O)OCC=C)[C@]57C(=O)Nc8ccccc87)C(=O)O[C@@H]([C@@H]6c9ccccc9)c%10ccccc%10 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 H22 compound treatment 211950.0 -139000.0 -0.69 202940.0 -192000.0 -0.9 -1.1282 -0.9916 3221310 PK04_130158 C[C@@H]1[C@H]([C@H](CCn2cc(nn2)[C@H](O)c3ccccc3)O[C@@]14C(=O)N(c5ccccc54)c6ccccc6)[Si](C)(C)F 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 H23 compound treatment 377440.0 26600.0 0.13 421790.0 27200.0 0.13 0.1842 0.9998 3176203 PK04_130159 OCCOc1cccc(c1)[C@H]2[C@H](C[C@@H]3N2C(=O)[C@@H]4CCCN4C3=O)C(=O)OCCOc5ccc(cc5)[C@H]6N7[C@@H]([C@@H](C(=O)OCC=C)[C@]68C(=O)Nc9ccccc98)C(=O)O[C@@H]([C@@H]7c%10ccccc%10)c%11ccccc%11 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 H24 compound treatment 186960.0 -164000.0 -0.82 215710.0 -179000.0 -0.84 -1.1739 -0.9999 3221312 PK04_130160 C[C@H]1[C@@H]([C@@H](CCn2cc(nn2)[C@H](O)c3ccccc3)O[C@]14C(=O)N(c5ccccc54)c6ccccc6)[Si](C)(C)F 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 I01 compound treatment 216500.0 -134000.0 -0.67 432320.0 37700.0 0.18 -0.3492 -0.5031 3221313 PK04_130161 OCCCCO[C@H]1C[C@H](C=C(O1)C(=O)NCc2ccc(Cl)cc2)c3cccs3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 I02 compound treatment 472870.0 122000.0 0.61 477620.0 83000.0 0.39 0.7069 0.9768 3080209 PK04_130162 CO[C@H](CCO)[C@H](OC(=O)Nc1ccc(OC)cc1)c2ccc(O)c(F)c2 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 I03 compound treatment 260200.0 -90700.0 -0.45 490620.0 96000.0 0.45 -9.0E-4 -0.0015 3221314 PK04_130163 Nc1ccccc1NC(=O)C2=C[C@@H](C[C@H](OCCCCO)O2)c3cccs3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 I04 compound treatment 461780.0 111000.0 0.55 483520.0 88900.0 0.42 0.6874 0.9904 3069956 PK04_130164 CO[C@@H](C=C)[C@@H](O)c1ccc(OC)c(O)c1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 I05 mock treatment 414930.0 64100.0 0.32 187380.0 -207000.0 -0.97 -0.4631 -0.4513 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 I06 mock treatment 311730.0 -39100.0 -0.2 495280.0 101000.0 0.47 0.1965 0.3838 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 I07 compound treatment 412060.0 61200.0 0.31 279310.0 -115000.0 -0.54 -0.1674 -0.2689 3221316 PK04_130165 COC(CN(C)C(=O)C1=C[C@@H](C[C@H](OCCCCO)O1)c2cccs2)OC 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 I08 compound treatment 508700.0 158000.0 0.79 504930.0 110000.0 0.52 0.9243 0.9794 3211693 PK04_130166 CO[C@H](CCO)[C@H](O)c1ccc(O)c(F)c1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 I09 compound treatment 266570.0 -84300.0 -0.42 247210.0 -147000.0 -0.69 -0.788 -0.9714 2019335 PK04_130167 COC(=O)c1ccc(cc1)[C@@H]2C[C@H](OCCCCO)OC(=C2)C(=O)O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 I10 compound treatment 338740.0 -12100.0 -0.06 268570.0 -126000.0 -0.59 -0.4621 -0.7753 3080278 PK04_130168 CSc1ccc(NC(=O)O[C@@H]([C@H](C)CCO)c2ccc(O)c3ccccc23)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 I11 compound treatment 213980.0 -137000.0 -0.68 466240.0 71600.0 0.34 -0.2453 -0.3218 3221318 PK04_130169 COc1cc2c[n+](Cc3cc4OCOc4cc3Br)ccc2cc1O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 I12 compound treatment 334260.0 -16600.0 -0.08 297300.0 -97300.0 -0.46 -0.3824 -0.8218 3211911 PK04_130170 COc1ccc(NC(=O)O[C@@H]([C@@H](C)CCO)c2ccc(O)c3ccccc23)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 I13 compound treatment 343700.0 -7160.0 -0.04 468900.0 74300.0 0.35 0.2217 0.6314 3221319 PK04_130171 COc1cc2c[n+](Cc3sc4ccccc4c3Cl)ccc2cc1O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 I14 compound treatment 357980.0 7120.0 0.04 292860.0 -102000.0 -0.48 -0.3134 -0.6528 3080208 PK04_130172 COc1ccc(NC(=O)O[C@@H](CCCO)c2ccc(O)c(F)c2)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 I15 compound treatment 400200.0 49300.0 0.25 402610.0 7970.0 0.04 0.2008 0.8055 3221320 PK04_130173 COc1cc2c[n+](Cc3ccc(o3)[N+](=O)[O-])ccc2cc1O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 I16 compound treatment 395010.0 44100.0 0.22 240560.0 -154000.0 -0.72 -0.3565 -0.4707 3080223 PK04_130174 CO[C@@H](CCO)[C@@H](OC(=O)Nc1ccc(OC)cc1)c2ccc(OCCO)cc2 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 I17 compound treatment 405040.0 54200.0 0.27 310740.0 -83900.0 -0.39 -0.0877 -0.1833 3221321 PK04_130175 COc1cc2c[n+](Cc3cccc(OC(F)(F)F)c3)ccc2cc1O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 I18 compound treatment 182140.0 -169000.0 -0.84 187680.0 -207000.0 -0.97 -1.2842 -0.9974 3080282 PK04_130176 CSc1ccc(NC(=O)O[C@H]([C@H](C)C=C)c2ccc(O)c3ccccc23)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 I19 compound treatment 200600.0 -150000.0 -0.75 246420.0 -148000.0 -0.7 -1.0236 -0.9993 3221322 PK04_130177 COP(=O)(OC)/N=C\1/CC(=CC(N1Cc2cccc(OC(F)(F)F)c2)c3cccs3)CCCO 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 I20 compound treatment 302530.0 -48300.0 -0.24 288320.0 -106000.0 -0.5 -0.5243 -0.9442 3211594 PK04_130178 CO[C@H](C=C)[C@H](OC(=O)Nc1ccc(SC)cc1)c2ccc(OC)c(O)c2 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 I21 mock treatment 280650.0 -70200.0 -0.35 179160.0 -215000.0 -1.01 -0.9646 -0.8994 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 I22 mock treatment 434170.0 83300.0 0.42 259790.0 -135000.0 -0.63 -0.1543 -0.2034 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 I23 compound treatment 268370.0 -82500.0 -0.41 310980.0 -83700.0 -0.39 -0.5696 -0.9997 3221324 PK04_130179 COP(=O)(OC)/N=C\1/CC(=CC(N1Cc2cc3OCOc3cc2Br)c4cccs4)CCCO 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 I24 compound treatment 204900.0 -146000.0 -0.73 247200.0 -147000.0 -0.69 -1.0059 -0.9997 3211811 PK04_130180 CSc1ccc(NC(=O)O[C@H]([C@@H](C)CCO)c2ccc(OCCO)cc2)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 J01 compound treatment 319400.0 -31500.0 -0.16 461480.0 66800.0 0.31 0.1112 0.3164 3176788 PK04_130181 CN(C)CCCCNC(=O)[C@H]1C[C@@H]2N([C@H]1c3ccc(O)cc3)C(=O)[C@H](CCCCN)NC2=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 J02 compound treatment 178720.0 -172000.0 -0.86 193660.0 -201000.0 -0.95 -1.2764 -0.9989 3221326 PK04_130182 C[C@@H]1[C@H]([C@H](CCO)O[C@@]12C(=O)N(Cc3ccccc3)c4ccc(cc42)N5CCOC5=O)[Si](C)(C)F 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 J03 compound treatment 505810.0 155000.0 0.77 460050.0 65400.0 0.31 0.7648 0.9183 3176789 PK04_130183 NCCCCCCNC(=O)[C@H]1C[C@@H]2N([C@H]1c3ccc(O)cc3)C(=O)[C@H](CCCCN)NC2=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 J04 compound treatment 188640.0 -162000.0 -0.81 163630.0 -231000.0 -1.09 -1.3412 -0.9896 3221328 PK04_130184 C[C@H]1[C@@H]([C@@H](CCO)O[C@]12C(=O)N(Cc3cccc(c3)N(C=O)c4ccccc4)c5ccccc52)[Si](C)(C)F 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 J05 mock treatment 227680.0 -123000.0 -0.62 483360.0 88700.0 0.42 -0.1399 -0.1882 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 J06 mock treatment 390990.0 40100.0 0.2 517890.0 123000.0 0.58 0.5517 0.8993 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 J07 compound treatment 440250.0 89400.0 0.45 362880.0 -31800.0 -0.15 0.2101 0.4462 3052827 PK04_130185 Oc1ccc(cc1)[C@@H]2[C@@H](C[C@H]3N2C(=O)[C@H](Cc4ccccc4)NC3=O)C(=O)OCCOc5ccc(cc5)[C@H]6N7[C@@H]([C@@H](C(=O)OCC=C)[C@]68C(=O)Nc9ccccc98)C(=O)O[C@@H]([C@@H]7c%10ccccc%10)c%11ccccc%11 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 J08 compound treatment 129960.0 -221000.0 -1.1 192440.0 -202000.0 -0.95 -1.4526 -0.9973 3221330 PK04_130186 C[C@H]1[C@@H]([C@@H](CCO)O[C@]12C(=O)N(CC=C)c3ccc(cc32)N4CCOC4=O)[Si](C)(C)F 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 J09 compound treatment 175780.0 -175000.0 -0.87 511440.0 117000.0 0.55 -0.2298 -0.2226 3052794 PK04_130187 CN(C)CCCCNC(=O)[C@@H]1C[C@H]2N([C@@H]1c3ccc(O)cc3)C(=O)[C@H](Cc4ccccc4)NC2=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 J10 compound treatment 146400.0 -204000.0 -1.02 181790.0 -213000.0 -1.0 -1.43 -1.0 3221332 PK04_130188 C[C@@H]1[C@H]([C@H](CCO)O[C@@]12C(=O)N(CC=C)c3ccc(cc32)N4C(=O)c5cccc6cccc4c56)[Si](C)(C)F 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 J11 compound treatment 166170.0 -185000.0 -0.92 434660.0 40000.0 0.19 -0.5191 -0.5514 3176437 PK04_130189 CN(C)CCCCNC(=O)[C@@H]1C[C@H]2N([C@@H]1c3ccc(O)cc3)C(=O)[C@H](CCCCNC(=O)C)NC2=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 J12 compound treatment 156190.0 -195000.0 -0.97 182660.0 -212000.0 -1.0 -1.3925 -0.9999 3221334 PK04_130190 C[C@@H]1[C@H]([C@H](CCO)O[C@@]12C(=O)N(CC=C)c3ccc(cc32)N4CCOC4=O)[Si](C)(C)F 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 J13 compound treatment 166970.0 -184000.0 -0.92 187410.0 -207000.0 -0.97 -1.3387 -0.9996 3176038 PK04_130191 CC(C)C[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3cccc(OCCO)c3)C(=O)NCc4ccc(F)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 J14 compound treatment 191150.0 -160000.0 -0.8 200450.0 -194000.0 -0.91 -1.2099 -0.9977 3221335 PK04_130192 C[C@H]1[C@@H]([C@@H](CCO)O[C@]12C(=O)N(Cc3cccc(c3)N4CCC4=O)c5ccccc52)[Si](C)(C)F 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 J15 compound treatment 478080.0 127000.0 0.64 459120.0 64500.0 0.3 0.6638 0.9427 3052796 PK04_130193 Oc1ccc(cc1)[C@@H]2[C@@H](C[C@H]3N2C(=O)[C@H](Cc4ccccc4)NC3=O)C(=O)NCc5ccc(F)cc5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 J16 compound treatment 207310.0 -144000.0 -0.72 181410.0 -213000.0 -1.0 -1.2162 -0.9865 3221337 PK04_130194 C[C@H]1[C@@H]([C@@H](CCO)O[C@]12C(=O)N(Cc3ccccc3)c4ccc(cc42)N5CCCCC5=O)[Si](C)(C)F 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 J17 compound treatment 247520.0 -103000.0 -0.52 205570.0 -189000.0 -0.89 -0.9938 -0.9665 3176331 PK04_130195 CN(C)CCCCCCNC(=O)[C@H]1C[C@@H]2N([C@H]1c3cccc(OCCO)c3)C(=O)[C@H](CCCC[N+](C)(C)C)NC2=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 J18 compound treatment 224060.0 -127000.0 -0.63 208850.0 -186000.0 -0.87 -1.0657 -0.9875 3221339 PK04_130196 C[C@H]1[C@@H]([C@@H](CCO)O[C@]12C(=O)N(Cc3ccccc3)c4ccc(cc42)N5CCC5=O)[Si](C)(C)F 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 J19 compound treatment 457860.0 107000.0 0.53 255810.0 -139000.0 -0.65 -0.0838 -0.0994 3176671 PK04_130197 CN(C)CCCCCCNC(=O)[C@H]1C[C@@H]2N([C@H]1c3ccc(O)cc3)C(=O)CNC2=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 J20 compound treatment 316320.0 -34500.0 -0.17 218460.0 -176000.0 -0.83 -0.7079 -0.8364 3221341 PK04_130198 C[C@H]1[C@@H]([C@@H](CCO)O[C@]12C(=O)N(Cc3cccc(c3)N4C(=O)c5ccccc5Oc6ccccc46)c7ccccc72)[Si](C)(C)F 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 J21 mock treatment 288480.0 -62400.0 -0.31 202310.0 -192000.0 -0.9 -0.86 -0.8988 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 J22 mock treatment 216510.0 -134000.0 -0.67 435480.0 40800.0 0.19 -0.3386 -0.4852 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 J23 compound treatment 446320.0 95500.0 0.48 267840.0 -127000.0 -0.6 -0.0846 -0.1108 3176271 PK04_130199 OCCOc1cccc(c1)[C@H]2[C@H](C[C@@H]3N2C(=O)CNC3=O)C(=O)OCCOc4ccc(cc4)[C@H]5N6[C@@H]([C@@H](C(=O)OCC=C)[C@]57C(=O)Nc8ccccc87)C(=O)O[C@@H]([C@@H]6c9ccccc9)c%10ccccc%10 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 J24 compound treatment 215850.0 -135000.0 -0.67 207100.0 -188000.0 -0.88 -1.1006 -0.9912 3221343 PK04_130200 C[C@H]1[C@@H]([C@@H](CCO)O[C@]12C(=O)N(CC=C)c3ccc(cc32)N4C(=O)c5ccccc5Oc6ccccc46)[Si](C)(C)F 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 K01 compound treatment 203750.0 -147000.0 -0.73 362820.0 -31800.0 -0.15 -0.6254 -0.834 3221345 PK04_130201 COP(=O)(OC)/N=C\1/CC(=CC(N1Cc2cccc(OC(F)(F)F)c2)c3cccs3)c4ccc(CO)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 K02 compound treatment 431210.0 80300.0 0.4 416000.0 21400.0 0.1 0.3548 0.8577 3211905 PK04_130202 C[C@H](CCO)[C@H](O)c1ccc(O)c2ccccc12 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 K03 compound treatment 184860.0 -166000.0 -0.83 355710.0 -38900.0 -0.18 -0.7157 -0.843 3221347 PK04_130203 COc1ccc(CN2CCc3cc(OC)c(O)cc3C2C#Cc4ccccc4)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 K04 compound treatment 465610.0 115000.0 0.57 521440.0 127000.0 0.6 0.827 0.9998 3211691 PK04_130204 CSc1ccc(NC(=O)O[C@@H](CCCO)c2ccc(O)c(F)c2)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 K05 compound treatment 360730.0 9870.0 0.05 450610.0 56000.0 0.26 0.221 0.8252 3221348 PK04_130205 COc1cc2CCN(C)C(C#Cc3ccccc3)c2cc1O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 K06 compound treatment 455210.0 104000.0 0.52 497440.0 103000.0 0.48 0.7104 0.9993 3211813 PK04_130206 CSc1ccc(NC(=O)O[C@@H]([C@@H](C)CCO)c2ccc(OCCO)cc2)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 K07 mock treatment 507800.0 157000.0 0.78 168360.0 -226000.0 -1.06 -0.1983 -0.15 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 K08 mock treatment 207910.0 -143000.0 -0.71 230950.0 -164000.0 -0.77 -1.0493 -0.9993 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 K09 compound treatment 176530.0 -174000.0 -0.87 297780.0 -96900.0 -0.46 -0.9378 -0.9543 3221349 PK04_130207 COc1cc2CCN(Cc3ccc(o3)[N+](=O)[O-])C(C#Cc4ccccc4)c2cc1O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 K10 compound treatment 211290.0 -140000.0 -0.7 118300.0 -276000.0 -1.3 -1.412 -0.9573 3211817 PK04_130208 CSc1ccc(NC(=O)O[C@H](CC=C)c2ccc(O)c3ccccc23)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 K11 compound treatment 431360.0 80500.0 0.4 422240.0 27600.0 0.13 0.3761 0.8902 3221350 PK04_130209 COCC#CC1N(Cc2ccc(OC)cc2)CCc3cc(OC)c(O)cc13 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 K12 compound treatment 167720.0 -183000.0 -0.91 165680.0 -229000.0 -1.08 -1.4083 -0.9967 3080279 PK04_130210 C[C@@H](CCO)[C@@H](O)c1ccc(O)c2ccccc12 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 K13 compound treatment 223160.0 -128000.0 -0.64 479490.0 84900.0 0.4 -0.1688 -0.2243 3221351 PK04_130211 COCC#CC1N(C)CCc2cc(OC)c(O)cc12 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 K14 compound treatment 503680.0 153000.0 0.76 241440.0 -153000.0 -0.72 0.0302 0.0287 3080188 PK04_130212 CO[C@H](CCO)[C@H](O)c1ccc(OC)c(O)c1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 K15 mock treatment 191950.0 -159000.0 -0.79 300330.0 -94300.0 -0.44 -0.8749 -0.9622 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 K16 mock treatment 209920.0 -141000.0 -0.7 288160.0 -106000.0 -0.5 -0.8519 -0.9861 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 K17 compound treatment 161840.0 -189000.0 -0.94 246590.0 -148000.0 -0.7 -1.16 -0.9888 3221353 PK04_130213 COCC#CC1N(Cc2ccc(o2)[N+](=O)[O-])CCc3cc(OC)c(O)cc13 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 K18 compound treatment 396600.0 45700.0 0.23 511680.0 117000.0 0.55 0.5508 0.9241 3080221 PK04_130214 CO[C@H](CCO)[C@H](O)c1ccc(OCCO)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 K19 compound treatment 191060.0 -160000.0 -0.8 217460.0 -177000.0 -0.83 -1.1536 -0.9998 3221354 PK04_130215 COc1ccc(CN2CCc3cc(OC)c(O)cc3C2C#C)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 K20 compound treatment 175140.0 -176000.0 -0.88 338110.0 -56500.0 -0.27 -0.8086 -0.8817 3211696 PK04_130216 CO[C@@H](CCO)[C@@H](OC(=O)Nc1ccc(SC)cc1)c2ccc(O)c(F)c2 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 K21 compound treatment 171840.0 -179000.0 -0.89 210330.0 -184000.0 -0.87 -1.2452 -0.9999 3221356 PK04_130217 COc1cc2CCN(C)C(C#C)c2cc1O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 K22 compound treatment 191880.0 -159000.0 -0.79 201990.0 -193000.0 -0.91 -1.2022 -0.9978 3211816 PK04_130218 COc1ccc(NC(=O)O[C@H]([C@H](C)CCO)c2ccc(OCCO)cc2)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 K23 mock treatment 317670.0 -33200.0 -0.17 441250.0 46600.0 0.22 0.0378 0.1376 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 K24 mock treatment 401090.0 50200.0 0.25 392960.0 -1680.0 -0.01 0.1718 0.6846 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 L01 compound treatment 388210.0 37300.0 0.19 508870.0 114000.0 0.54 0.5118 0.8999 3176382 PK04_130219 CN(C)CCCCNC(=O)[C@H]1C[C@@H]2N([C@H]1c3cccc(OCCO)c3)C(=O)[C@H](CCCCN)NC2=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 L02 compound treatment 501600.0 151000.0 0.75 493560.0 98900.0 0.47 0.8614 0.9733 3221357 PK04_130220 C[C@@H]1[C@H]([C@H](CCO)O[C@@]12C(=O)N(CC=C)c3ccc(cc32)N4CCCCC4=O)[Si](C)(C)F 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 L03 compound treatment 475790.0 125000.0 0.62 349530.0 -45100.0 -0.21 0.2912 0.4418 3176383 PK04_130221 NCCCCCCNC(=O)[C@H]1C[C@@H]2N([C@H]1c3cccc(OCCO)c3)C(=O)[C@H](CCCCN)NC2=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 L04 compound treatment 282090.0 -68800.0 -0.34 222360.0 -172000.0 -0.81 -0.8159 -0.927 3221359 PK04_130222 C[C@H](O)C(=O)Nc1ccc2N(CC=C)C(=O)[C@]3(O[C@H](CCO)[C@H]([C@@H]3C)[Si](C)(C)F)c2c1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 L05 compound treatment 234720.0 -116000.0 -0.58 256510.0 -138000.0 -0.65 -0.8696 -0.9984 3052642 PK04_130223 OCCOc1cccc(c1)[C@@H]2[C@@H](C[C@H]3N2C(=O)[C@@H]4CCCN4C3=O)C(=O)OCCOc5ccc(cc5)[C@H]6N7[C@@H]([C@@H](C(=O)OCC=C)[C@]68C(=O)Nc9ccccc98)C(=O)O[C@@H]([C@@H]7c%10ccccc%10)c%11ccccc%11 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 L06 compound treatment 424380.0 73500.0 0.37 163800.0 -231000.0 -1.09 -0.5081 -0.4433 3221361 PK04_130224 C[C@H]1[C@@H]([C@@H](CCO)O[C@]12C(=O)N(CC=C)c3ccc(cc32)N4CCC4=O)[Si](C)(C)F 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 L07 mock treatment 214780.0 -136000.0 -0.68 280450.0 -114000.0 -0.54 -0.8604 -0.9932 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 L08 mock treatment 377440.0 26600.0 0.13 210260.0 -184000.0 -0.87 -0.5194 -0.592 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 L09 compound treatment 474200.0 123000.0 0.62 514280.0 120000.0 0.56 0.8335 0.999 3176673 PK04_130225 CN(C)CCCCNC(=O)[C@@H]1C[C@H]2N([C@@H]1c3ccc(O)cc3)C(=O)CNC2=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 L10 compound treatment 155200.0 -196000.0 -0.98 138580.0 -256000.0 -1.2 -1.5426 -0.9946 3221363 PK04_130226 COc1ccc(cc1)C(=O)Nc2cccc(CN3C(=O)[C@]4(O[C@H](CCO)[C@H]([C@@H]4C)[Si](C)(C)F)c5ccccc35)c2 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 L11 compound treatment 194940.0 -156000.0 -0.78 465160.0 70500.0 0.33 -0.3161 -0.3734 3052529 PK04_130227 CN(C)CCCCNC(=O)[C@@H]1C[C@H]2N([C@@H]1c3cccc(OCCO)c3)C(=O)[C@H](CCCCNC(=O)C)NC2=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 L12 compound treatment 257540.0 -93300.0 -0.47 302420.0 -92200.0 -0.43 -0.6363 -0.9994 3221365 PK04_130228 C[C@@H]1[C@H]([C@H](CCO)O[C@@]12C(=O)N(Cc3cccc(c3)N(C=O)c4ccccc4)c5ccccc52)[Si](C)(C)F 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 L13 compound treatment 466340.0 115000.0 0.58 495650.0 101000.0 0.48 0.7438 0.9954 3052693 PK04_130229 CN(C)CCCC[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3cccc(OCCO)c3)C(=O)NCc4ccc(F)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 L14 compound treatment 153120.0 -198000.0 -0.99 315380.0 -79300.0 -0.37 -0.962 -0.9113 3221366 PK04_130230 C[C@@H]1[C@H]([C@H](CCO)O[C@@]12C(=O)N(Cc3ccccc3)c4ccc(NC(=O)C)cc42)[Si](C)(C)F 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 L15 mock treatment 483410.0 133000.0 0.66 362120.0 -32500.0 -0.15 0.36 0.5298 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 L16 mock treatment 429340.0 78500.0 0.39 467140.0 72500.0 0.34 0.5183 0.9976 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 L17 compound treatment 401890.0 51000.0 0.25 291950.0 -103000.0 -0.48 -0.1613 -0.2954 3176205 PK04_130231 CN(C)CCCCCCNC(=O)[C@H]1C[C@@H]2N([C@H]1c3cccc(OCCO)c3)C(=O)CNC2=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 L18 compound treatment 170240.0 -181000.0 -0.9 198480.0 -196000.0 -0.92 -1.2903 -0.9999 3221368 PK04_130232 C[C@H]1[C@@H]([C@@H](CCO)O[C@]12C(=O)N(Cc3cccc(c3)N4CCOC4=O)c5ccccc52)[Si](C)(C)F 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 L19 compound treatment 208480.0 -142000.0 -0.71 462940.0 68300.0 0.32 -0.2757 -0.3533 3176125 PK04_130233 CN(C)CCCCCCNC(=O)[C@H]1C[C@@H]2N([C@H]1c3cccc(OCCO)c3)C(=O)[C@@H]4CCCN4C2=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 L20 compound treatment 166560.0 -184000.0 -0.92 146240.0 -248000.0 -1.17 -1.477 -0.993 3221370 PK04_130234 COc1ccc(cc1)C(=O)Nc2ccc3N(CC=C)C(=O)[C@@]4(O[C@@H](CCO)[C@@H]([C@H]4C)[Si](C)(C)F)c3c2 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 L21 compound treatment 296800.0 -54100.0 -0.27 330760.0 -63900.0 -0.3 -0.4034 -0.9986 3052877 PK04_130235 Oc1ccc(cc1)[C@H]2[C@H](C[C@@H]3N2C(=O)CNC3=O)C(=O)OCCOc4ccc(cc4)[C@H]5N6[C@@H]([C@@H](C(=O)OCC=C)[C@]57C(=O)Nc8ccccc87)C(=O)O[C@@H]([C@@H]6c9ccccc9)c%10ccccc%10 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 L22 compound treatment 175930.0 -175000.0 -0.87 178190.0 -216000.0 -1.02 -1.3377 -0.9971 3221372 PK04_130236 C[C@H]1[C@@H]([C@@H](CCO)O[C@]12C(=O)N(CC=C)c3ccc(NC(=O)C)cc32)[Si](C)(C)F 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 L23 mock treatment 315120.0 -35700.0 -0.18 274370.0 -120000.0 -0.57 -0.5262 -0.8871 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 L24 mock treatment 230310.0 -121000.0 -0.6 423680.0 29000.0 0.14 -0.3291 -0.5331 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 M01 compound treatment 211730.0 -139000.0 -0.69 368070.0 -26600.0 -0.12 -0.5797 -0.8211 3221374 PK04_130237 COc1cc2CCN(Cc3ccc(o3)[N+](=O)[O-])C(C#C)c2cc1O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 M02 compound treatment 486110.0 135000.0 0.68 524440.0 130000.0 0.61 0.9094 0.9987 3211810 PK04_130238 C[C@@H](CCO)[C@@H](O)c1ccc(OCCO)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 M03 compound treatment 474120.0 123000.0 0.62 476270.0 81600.0 0.38 0.7068 0.9742 3221375 PK04_130239 CC(C)C(=C=CC[C@@H](O)c1ccc(OCCO)cc1)C[C@@H](O)c2cc(Cl)cc(Cl)c2O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 M04 compound treatment 479400.0 129000.0 0.64 393850.0 -786.0 0.0 0.4513 0.703 3080224 PK04_130240 COc1ccc(NC(=O)O[C@@H]([C@H](C)CCO)c2ccc(OCCO)cc2)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 M05 compound treatment 394750.0 43900.0 0.22 452320.0 57700.0 0.27 0.3469 0.9944 3221376 PK04_130241 COCC(=C=CC[C@@H](O)c1ccc(OCCO)cc1)C[C@@H](O)c2cc(Cl)cc(Cl)c2O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 M06 compound treatment 293680.0 -57200.0 -0.29 272160.0 -122000.0 -0.58 -0.6093 -0.9476 3211820 PK04_130242 COc1ccc(NC(=O)O[C@@H](CCCO)c2ccc(O)c3ccccc23)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 M07 compound treatment 497990.0 147000.0 0.73 467860.0 73200.0 0.34 0.7632 0.9404 3221377 PK04_130243 CCCCC(=C=CC[C@@H](O)c1cccc(OCCO)c1)C[C@@H](O)c2cc(Cl)cc(Cl)c2O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 M08 compound treatment 207200.0 -144000.0 -0.72 408800.0 14200.0 0.07 -0.4603 -0.6387 3211694 PK04_130244 CO[C@H](CCO)[C@H](OC(=O)Nc1ccc(SC)cc1)c2ccc(O)c(F)c2 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 M09 mock treatment 263250.0 -87600.0 -0.44 521340.0 127000.0 0.6 0.112 0.1515 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 M10 mock treatment 220100.0 -131000.0 -0.65 489380.0 94700.0 0.45 -0.1467 -0.1855 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 M11 compound treatment 185680.0 -165000.0 -0.82 457920.0 63300.0 0.3 -0.3729 -0.4251 3221378 PK04_130245 CC(C)C(=C=CC[C@@H](O)c1cccc(OCCO)c1)C[C@@H](O)c2cc(Cl)cc(Cl)c2O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 M12 compound treatment 405990.0 55100.0 0.28 221710.0 -173000.0 -0.81 -0.3805 -0.443 3080189 PK04_130246 CO[C@H](CCO)[C@H](OC(=O)Nc1ccc(SC)cc1)c2ccc(OC)c(O)c2 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 M13 mock treatment 219040.0 -132000.0 -0.66 510170.0 116000.0 0.54 -0.0813 -0.0952 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 M14 mock treatment 252490.0 -98400.0 -0.49 302040.0 -92600.0 -0.44 -0.6554 -0.9982 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 M15 compound treatment 406570.0 55700.0 0.28 255890.0 -139000.0 -0.65 -0.2647 -0.3731 3221379 PK04_130247 COCC(=C=CC[C@@H](O)c1cccc(OCCO)c1)C[C@@H](O)c2cc(Cl)cc(Cl)c2O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 M16 compound treatment 437060.0 86200.0 0.43 483400.0 88800.0 0.42 0.5997 0.9999 3211679 PK04_130248 CO[C@@H](CCO)[C@@H](O)c1ccc(OC)c(O)c1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 M17 compound treatment 230750.0 -120000.0 -0.6 452560.0 57900.0 0.27 -0.2315 -0.3514 3221380 PK04_130249 CCCCC(=C=CC[C@@H](O)c1ccccc1OCCO)C[C@@H](O)c2cc(Cl)cc(Cl)c2O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 M18 compound treatment 237760.0 -113000.0 -0.56 368520.0 -26100.0 -0.12 -0.4863 -0.8412 3211808 PK04_130250 C[C@H](CCO)[C@H](O)c1ccc(OCCO)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 M19 mock treatment 320680.0 -30200.0 -0.15 466760.0 72100.0 0.34 0.1333 0.3591 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 M20 compound treatment 185410.0 -165000.0 -0.83 208730.0 -186000.0 -0.87 -1.2026 -0.9996 3080271 PK04_130251 CSc1ccc(NC(=O)O[C@H](CCCO)c2ccc(O)c3ccccc23)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 M21 mock treatment 318420.0 -32400.0 -0.16 351040.0 -43600.0 -0.21 -0.2596 -0.9932 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 M22 compound treatment 308010.0 -42900.0 -0.21 288530.0 -106000.0 -0.5 -0.5042 -0.9286 3211910 PK04_130252 C[C@@H](CCO)[C@H](O)c1ccc(O)c2ccccc12 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 M23 mock treatment 281610.0 -69300.0 -0.35 317530.0 -77100.0 -0.36 -0.501 -0.9997 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 M24 compound treatment 144930.0 -206000.0 -1.03 239900.0 -155000.0 -0.73 -1.2419 -0.9857 3211692 PK04_130253 COc1ccc(NC(=O)O[C@@H](CC=C)c2ccc(O)c(F)c2)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 N01 compound treatment 186450.0 -164000.0 -0.82 517630.0 123000.0 0.58 -0.1716 -0.1708 3176433 PK04_130254 NCCCCCNC(=O)[C@H]1C[C@@H]2N([C@H]1c3cccc(OCCO)c3)C(=O)[C@H](CCCCN)NC2=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 N02 compound treatment 216640.0 -134000.0 -0.67 140390.0 -254000.0 -1.2 -1.3196 -0.9626 3221382 PK04_130255 C[C@@H]1[C@H]([C@H](CCO)O[C@@]12C(=O)N(Cc3ccccc3)c4ccc(cc42)N5CCCCC5=O)[Si](C)(C)F 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 N03 compound treatment 389690.0 38800.0 0.19 526850.0 132000.0 0.62 0.5769 0.8856 3175967 PK04_130256 CC(=O)NCCCC[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3cccc(OCCO)c3)C(=O)OCCOc4ccc(cc4)[C@H]5N6[C@@H]([C@@H](C(=O)OCC=C)[C@]57C(=O)Nc8ccccc87)C(=O)O[C@@H]([C@@H]6c9ccccc9)c%10ccccc%10 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 N04 compound treatment 301280.0 -49600.0 -0.25 481680.0 87000.0 0.41 0.1144 0.2391 3221383 PK04_130257 C[C@H]1[C@@H]([C@@H](CCO)O[C@]12C(=O)N(Cc3ccccc3)c4ccc(cc42)N5C(=O)c6ccccc6Oc7ccccc57)[Si](C)(C)F 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 N05 compound treatment 354110.0 3250.0 0.02 317410.0 -77200.0 -0.36 -0.2454 -0.6748 3052653 PK04_130258 OCCOc1cccc(c1)[C@@H]2[C@@H](C[C@H]3N2C(=O)CNC3=O)C(=O)OCCOc4ccc(cc4)[C@H]5N6[C@@H]([C@@H](C(=O)OCC=C)[C@]57C(=O)Nc8ccccc87)C(=O)O[C@@H]([C@@H]6c9ccccc9)c%10ccccc%10 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 N06 compound treatment 445330.0 94500.0 0.47 177650.0 -217000.0 -1.02 -0.3881 -0.3451 3221385 PK04_130259 C[C@H]1[C@@H]([C@@H](CCO)O[C@]12C(=O)N(CC=C)c3ccc(cc32)N4C(=O)c5cccc6cccc4c56)[Si](C)(C)F 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 N07 compound treatment 289500.0 -61400.0 -0.31 176960.0 -218000.0 -1.02 -0.9407 -0.8802 3052758 PK04_130260 CC(C)C[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3ccc(O)cc3)C(=O)NCCCCN(C)C 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 N08 compound treatment 163360.0 -188000.0 -0.94 219070.0 -176000.0 -0.83 -1.2461 -0.998 3221386 PK04_130261 C[C@H]1[C@@H]([C@@H](CCO)O[C@]12C(=O)N(Cc3ccc(cc3)N4CCCCC4=O)c5ccccc52)[Si](C)(C)F 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 N09 mock treatment 466720.0 116000.0 0.58 222350.0 -172000.0 -0.81 -0.1638 -0.1645 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 N10 mock treatment 170730.0 -180000.0 -0.9 249240.0 -145000.0 -0.68 -1.1197 -0.9908 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 N11 compound treatment 322910.0 -28000.0 -0.14 221860.0 -173000.0 -0.81 -0.6734 -0.8166 3176332 PK04_130262 CN(C)CCCCNC(=O)[C@@H]1C[C@H]2N([C@@H]1c3cccc(OCCO)c3)C(=O)[C@H](CCCC[N+](C)(C)C)NC2=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 N12 compound treatment 150920.0 -200000.0 -1.0 227780.0 -167000.0 -0.78 -1.2611 -0.9929 3221388 PK04_130263 C[C@H]1[C@@H]([C@@H](CCO)O[C@]12C(=O)N(Cc3ccccc3)c4ccc(NC(=O)C)cc42)[Si](C)(C)F 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 N13 mock treatment 204680.0 -146000.0 -0.73 451740.0 57100.0 0.27 -0.3263 -0.4195 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 N14 mock treatment 270030.0 -80800.0 -0.4 480120.0 85500.0 0.4 -0.0011 -0.002 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 N15 compound treatment 181120.0 -170000.0 -0.85 212160.0 -182000.0 -0.86 -1.2064 -1.0 3176440 PK04_130264 CC(=O)NCCCC[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3ccc(O)cc3)C(=O)NCc4ccc(F)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 N16 compound treatment 418850.0 68000.0 0.34 310040.0 -84600.0 -0.4 -0.0413 -0.0789 3221389 PK04_130265 C[C@@H]1[C@H]([C@H](CCO)O[C@@]12C(=O)N(Cc3cccc(c3)N4C(=O)c5cccc6cccc4c56)c7ccccc72)[Si](C)(C)F 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 N17 compound treatment 205780.0 -145000.0 -0.72 279200.0 -115000.0 -0.54 -0.8963 -0.9899 3174818 PK04_130266 CN(C)CCCCCCNC(=O)[C@H]1C[C@@H]2N([C@H]1c3cccc(OCCO)c3)C(=O)[C@H](CCCCNC(=O)C)NC2=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 N18 compound treatment 182730.0 -168000.0 -0.84 186970.0 -208000.0 -0.98 -1.2845 -0.9972 3221391 PK04_130267 C[C@H]1[C@@H]([C@@H](CCO)O[C@]12C(=O)N(Cc3ccccc3)c4ccc(cc42)N5CCOC5=O)[Si](C)(C)F 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 N19 compound treatment 196040.0 -155000.0 -0.77 396610.0 1970.0 0.01 -0.5402 -0.6986 3052539 PK04_130268 CC(C)C[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3cccc(OCCO)c3)C(=O)NCCCCCCN(C)C 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 N20 compound treatment 165330.0 -186000.0 -0.93 138180.0 -256000.0 -1.21 -1.5082 -0.9915 3221392 PK04_130269 C[C@@H]1[C@H]([C@H](CCO)O[C@@]12C(=O)N(Cc3ccccc3)c4ccc(cc42)N(C=O)c5ccccc5)[Si](C)(C)F 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 N21 compound treatment 401960.0 51100.0 0.26 364160.0 -30500.0 -0.14 0.0791 0.2702 3052582 PK04_130270 CC(C)C[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3cccc(OCCO)c3)C(=O)OCCOc4ccc(cc4)[C@H]5N6[C@@H]([C@@H](C(=O)OCC=C)[C@]57C(=O)Nc8ccccc87)C(=O)O[C@@H]([C@@H]6c9ccccc9)c%10ccccc%10 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 N22 compound treatment 230030.0 -121000.0 -0.6 152210.0 -242000.0 -1.14 -1.233 -0.9557 3221394 PK04_130271 C[C@H](O)C(=O)Nc1ccc(CN2C(=O)[C@@]3(O[C@@H](CCO)[C@@H]([C@H]3C)[Si](C)(C)F)c4ccccc24)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 N23 compound treatment 362460.0 11600.0 0.06 323460.0 -71200.0 -0.33 -0.1958 -0.5762 3052791 PK04_130272 CC(C)C[C@@H]1NC(=O)[C@@H]2C[C@@H]([C@@H](N2C1=O)c3ccc(O)cc3)C(=O)OCCOc4ccc(cc4)[C@H]5N6[C@@H]([C@@H](C(=O)OCC=C)[C@]57C(=O)Nc8ccccc87)C(=O)O[C@@H]([C@@H]6c9ccccc9)c%10ccccc%10 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 N24 compound treatment 156270.0 -195000.0 -0.97 159620.0 -235000.0 -1.11 -1.4689 -0.9979 3221396 PK04_130273 C[C@H]1[C@@H]([C@@H](CCO)O[C@]12C(=O)N(Cc3cccc(NC(=O)C)c3)c4ccccc42)[Si](C)(C)F 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 O01 mock treatment 471840.0 121000.0 0.6 496340.0 102000.0 0.48 0.7655 0.9933 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 O02 compound treatment 392210.0 41300.0 0.21 433990.0 39400.0 0.19 0.2769 0.9985 3211913 PK04_130274 CSc1ccc(NC(=O)O[C@H]([C@H](C)CCO)c2ccc(O)c3ccccc23)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 O03 mock treatment 470160.0 119000.0 0.6 564580.0 170000.0 0.8 0.9866 0.9895 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 O04 mock treatment 445120.0 94300.0 0.47 510050.0 115000.0 0.54 0.7168 0.9975 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 O05 mock treatment 214410.0 -136000.0 -0.68 300450.0 -94200.0 -0.44 -0.7952 -0.9782 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 O06 mock treatment 511900.0 161000.0 0.8 528540.0 134000.0 0.63 1.0141 0.9927 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 O07 mock treatment 426560.0 75700.0 0.38 285060.0 -110000.0 -0.52 -0.0971 -0.1519 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 O08 mock treatment 464160.0 113000.0 0.57 544480.0 150000.0 0.7 0.8985 0.9941 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 O09 mock treatment 216450.0 -134000.0 -0.67 520480.0 126000.0 0.59 -0.0561 -0.0627 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 O10 mock treatment 535000.0 184000.0 0.92 524040.0 129000.0 0.61 1.0807 0.9799 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 O11 mock treatment 192280.0 -159000.0 -0.79 446810.0 52200.0 0.25 -0.3865 -0.4661 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 O12 mock treatment 475250.0 124000.0 0.62 390680.0 -3960.0 -0.02 0.4261 0.6856 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 O13 mock treatment 423170.0 72300.0 0.36 489080.0 94400.0 0.44 0.5695 0.9947 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 O14 mock treatment 370240.0 19400.0 0.1 498660.0 104000.0 0.49 0.4144 0.8309 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 O15 mock treatment 434830.0 84000.0 0.42 277930.0 -117000.0 -0.55 -0.0916 -0.1326 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 O16 mock treatment 397230.0 46400.0 0.23 358330.0 -36300.0 -0.17 0.043 0.1495 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 O17 mock treatment 309280.0 -41600.0 -0.21 505980.0 111000.0 0.52 0.2235 0.3967 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 O18 mock treatment 485280.0 134000.0 0.67 402080.0 7440.0 0.04 0.4995 0.743 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 O19 mock treatment 426720.0 75900.0 0.38 439850.0 45200.0 0.21 0.4183 0.9627 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 O20 mock treatment 284960.0 -65900.0 -0.33 399680.0 5040.0 0.02 -0.216 -0.6544 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 O21 mock treatment 253320.0 -97500.0 -0.49 243390.0 -151000.0 -0.71 -0.8475 -0.9829 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 O22 mock treatment 289620.0 -61200.0 -0.31 421250.0 26600.0 0.13 -0.1278 -0.3866 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 O23 mock treatment 387650.0 36800.0 0.18 348820.0 -45800.0 -0.22 -0.0225 -0.0793 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 O24 mock treatment 303520.0 -47300.0 -0.24 484510.0 89900.0 0.42 0.1317 0.272 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 P01 compound treatment 244280.0 -107000.0 -0.53 472190.0 77600.0 0.36 -0.1185 -0.1836 3175838 PK04_130275 NCCCCCNC(=O)[C@H]1C[C@@H]2N([C@H]1c3ccc(O)cc3)C(=O)[C@H](CCCCN)NC2=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 P02 compound treatment 239210.0 -112000.0 -0.56 346660.0 -48000.0 -0.23 -0.5539 -0.9207 3221398 PK04_130276 C[C@@H]1[C@H]([C@H](CCO)O[C@@]12C(=O)N(Cc3ccc(cc3)N4CCCCC4=O)c5ccccc52)[Si](C)(C)F 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 P03 compound treatment 395460.0 44600.0 0.22 192720.0 -202000.0 -0.95 -0.5141 -0.527 3052740 PK04_130277 C[N+](C)(C)CCCC[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3cccc(OCCO)c3)C(=O)OCCOc4ccc(cc4)[C@H]5N6[C@@H]([C@@H](C(=O)OCC=C)[C@]57C(=O)Nc8ccccc87)C(=O)O[C@@H]([C@@H]6c9ccccc9)c%10ccccc%10 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 P04 compound treatment 161440.0 -189000.0 -0.95 156660.0 -238000.0 -1.12 -1.4605 -0.9965 3221399 PK04_130278 C[C@@H]1[C@H]([C@H](CCO)O[C@@]12C(=O)N(Cc3cccc(NC(=O)C)c3)c4ccccc42)[Si](C)(C)F 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 P05 compound treatment 143610.0 -207000.0 -1.04 165990.0 -229000.0 -1.08 -1.4924 -0.9998 3176784 PK04_130279 C[N+](C)(C)CCCC[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3ccc(O)cc3)C(=O)OCCOc4ccc(cc4)[C@H]5N6[C@@H]([C@@H](C(=O)OCC=C)[C@]57C(=O)Nc8ccccc87)C(=O)O[C@@H]([C@@H]6c9ccccc9)c%10ccccc%10 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 P06 compound treatment 165600.0 -185000.0 -0.93 356440.0 -38200.0 -0.18 -0.7813 -0.8289 3221400 PK04_130280 C[C@@H]1[C@H]([C@H](CCO)O[C@@]12C(=O)N(Cc3ccccc3)c4ccc(cc42)N5C(=O)c6ccccc6Oc7ccccc57)[Si](C)(C)F 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 P07 compound treatment 183370.0 -167000.0 -0.84 269620.0 -125000.0 -0.59 -1.0073 -0.9851 3052752 PK04_130281 CC(=O)NCCCC[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3ccc(O)cc3)C(=O)NCCCC[N+](C)(C)C 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 P08 compound treatment 134620.0 -216000.0 -1.08 186670.0 -208000.0 -0.98 -1.4554 -0.9988 3221401 PK04_130282 C[C@@H]1[C@H]([C@H](CCO)O[C@@]12C(=O)N(Cc3ccccc3)c4ccc(cc42)N5CCC5=O)[Si](C)(C)F 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 P09 compound treatment 182420.0 -168000.0 -0.84 195370.0 -199000.0 -0.94 -1.2576 -0.9985 3052788 PK04_130283 CC(C)C[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3ccc(O)cc3)C(=O)NCCCC[N+](C)(C)C 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 P10 compound treatment 219330.0 -132000.0 -0.66 272500.0 -122000.0 -0.57 -0.8707 -0.9978 3221402 PK04_130284 C[C@@H]1[C@H]([C@H](CCO)O[C@@]12C(=O)N(Cc3cccc(c3)N4CCCCC4=O)c5ccccc52)[Si](C)(C)F 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 P11 mock treatment 208020.0 -143000.0 -0.71 421950.0 27300.0 0.13 -0.4136 -0.5706 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 P12 mock treatment 158170.0 -193000.0 -0.96 412270.0 17600.0 0.08 -0.6219 -0.6438 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 P13 compound treatment 144040.0 -207000.0 -1.03 415210.0 20600.0 0.1 -0.662 -0.6381 3052846 PK04_130285 C[N+](C)(C)CCCCNC(=O)[C@@H]1C[C@H]2N([C@@H]1c3ccc(O)cc3)C(=O)CNC2=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 P14 compound treatment 129460.0 -221000.0 -1.11 131540.0 -263000.0 -1.24 -1.657 -0.9984 3221404 PK04_130286 C[C@H](O)C(=O)Nc1cccc(CN2C(=O)[C@]3(O[C@H](CCO)[C@H]([C@@H]3C)[Si](C)(C)F)c4ccccc24)c1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 P15 compound treatment 404890.0 54000.0 0.27 213290.0 -181000.0 -0.85 -0.4123 -0.4609 3052836 PK04_130287 C[N+](C)(C)CCCCNC(=O)[C@@H]1C[C@H]2N([C@@H]1c3ccc(O)cc3)C(=O)[C@@H]4CCCN4C2=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 P16 compound treatment 130650.0 -220000.0 -1.1 185120.0 -210000.0 -0.99 -1.4746 -0.9985 3221406 PK04_130288 C[C@H]1[C@@H]([C@@H](CCO)O[C@]12C(=O)N(Cc3cccc(c3)N4CCCCC4=O)c5ccccc52)[Si](C)(C)F 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 P17 compound treatment 189850.0 -161000.0 -0.8 308980.0 -85700.0 -0.4 -0.8535 -0.9489 3176730 PK04_130289 C[N+](C)(C)CCCCNC(=O)[C@@H]1C[C@H]2N([C@@H]1c3ccc(O)cc3)C(=O)[C@H](CCCC[N+](C)(C)C)NC2=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 P18 compound treatment 150030.0 -201000.0 -1.0 151070.0 -244000.0 -1.15 -1.5194 -0.9978 3221407 PK04_130290 C[C@H](O)C(=O)Nc1ccc(CN2C(=O)[C@]3(O[C@H](CCO)[C@H]([C@@H]3C)[Si](C)(C)F)c4ccccc24)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 P19 compound treatment 192030.0 -159000.0 -0.79 190580.0 -204000.0 -0.96 -1.2396 -0.9955 3052799 PK04_130291 C[N+](C)(C)CCCCNC(=O)[C@@H]1C[C@H]2N([C@@H]1c3ccc(O)cc3)C(=O)[C@H](Cc4ccccc4)NC2=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 P20 compound treatment 109920.0 -241000.0 -1.2 143650.0 -251000.0 -1.18 -1.6857 -1.0 3221408 PK04_130292 COc1ccc(cc1)C(=O)Nc2ccc(CN3C(=O)[C@]4(O[C@H](CCO)[C@H]([C@@H]4C)[Si](C)(C)F)c5ccccc35)cc2 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 P21 compound treatment 251170.0 -99700.0 -0.5 242260.0 -152000.0 -0.72 -0.8589 -0.9842 3176730 PK04_130293 C[N+](C)(C)CCCCNC(=O)[C@@H]1C[C@H]2N([C@@H]1c3ccc(O)cc3)C(=O)[C@H](CCCC[N+](C)(C)C)NC2=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 P22 compound treatment 130980.0 -220000.0 -1.1 162470.0 -232000.0 -1.09 -1.5487 -1.0 3221410 PK04_130294 C[C@@H]1[C@H]([C@H](CCO)O[C@@]12C(=O)N(CC=C)c3ccc(cc32)N4CCC4=O)[Si](C)(C)F 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 P23 compound treatment 418560.0 67700.0 0.34 220850.0 -174000.0 -0.82 -0.3389 -0.3831 3176786 PK04_130295 NCCCC[C@@H]1NC(=O)[C@H]2C[C@H]([C@H](N2C1=O)c3ccc(O)cc3)C(=O)O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2130 P24 compound treatment 154580.0 -196000.0 -0.98 173150.0 -221000.0 -1.04 -1.4299 -0.9995 3221411 PK04_130296 C[C@H]1[C@@H]([C@@H](CCO)O[C@]12C(=O)N(Cc3cccc(c3)N4C(=O)COc5ccccc45)c6ccccc62)[Si](C)(C)F 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 A01 compound treatment 311690.0 -143000.0 -0.71 259240.0 -105000.0 -0.49 -0.8526 -0.984 3561840 PK04_181001 CC(C)(C)N(CC=C)C(=O)C1N(Cc2ccccc2)C(=O)C3C(C4OC13C=C4)C(=O)O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 A02 compound treatment 234080.0 -220000.0 -1.1 150300.0 -214000.0 -1.01 -1.489 -0.999 3561841 PK04_181002 COc1ccc(CN2[C@@H]3C(=O)N(Cc4ccccc4)CC=C[C@]53O[C@@H]6/C=C/CCC(=O)N(C)[C@H](C)[C@H](OC(=O)[C@@H]6[C@H]5C2=O)c7ccccc7)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 A03 compound treatment 424190.0 -30000.0 -0.15 319600.0 -44600.0 -0.21 -0.2545 -0.9864 3561843 PK04_181003 OC1CCC(CC1)N2C(C(=O)N(CC=C)c3ccccc3)C4(OC5C=C4)C(C5C(=O)OCC=C)C2=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 A04 compound treatment 394750.0 -59500.0 -0.3 286510.0 -77700.0 -0.37 -0.4685 -0.9947 2065615 PK04_181004 COc1ccc(CN2[C@H]3C(=O)N(Cc4ccccc4)C/C=C/CCC(=O)N(C)[C@H](C)[C@H](OC(=O)[C@@H]5[C@H]6O[C@]3(C=C6)[C@H]5C2=O)c7ccccc7)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 A05 compound treatment 141870.0 -312000.0 -1.56 325120.0 -39100.0 -0.18 -1.2332 -0.7851 3561844 PK04_181005 O=C(Cc1ccccc1)N(Cc2ccccc2)C(C(=O)NCc3ccccc3)c4ccco4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 A06 compound treatment 193600.0 -261000.0 -1.3 117790.0 -246000.0 -1.16 -1.7401 -0.9983 3561845 PK04_181006 CCCCCN1CC=C[C@@]23O[C@@H]4/C=C/CCC(=O)N(C)[C@H](C)[C@H](OC(=O)[C@@H]4[C@H]3C(=O)N([C@@H]2C1=O)c5ccccc5Cl)c6ccccc6 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 A07 compound treatment 387330.0 -66900.0 -0.33 138080.0 -226000.0 -1.06 -0.9884 -0.8865 3561847 PK04_181007 Cc1cccc2OC(CC(=O)c12)c3ccccc3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 A08 compound treatment 383860.0 -70400.0 -0.35 207930.0 -156000.0 -0.74 -0.7683 -0.9429 3561848 PK04_181008 CCCCCN1C/C=C/CCC(=O)N(C)[C@H](C)[C@H](OC(=O)[C@@H]2[C@H]3O[C@]4(C=C3)[C@H]2C(=O)N([C@H]4C1=O)c5ccccc5Cl)c6ccccc6 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 A09 compound treatment 204640.0 -250000.0 -1.25 328640.0 -35600.0 -0.17 -0.9998 -0.7949 3561850 PK04_181009 O=C(Cc1ccccc1)N(Cc2ccccc2)C(C(=O)NCc3ccccc3)c4ccccc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 A10 compound treatment 390690.0 -63500.0 -0.32 265280.0 -99000.0 -0.47 -0.5535 -0.9826 3561851 PK04_181010 CCOC(=O)[C@H]1C2OC3(C=C2)[C@H](N(C(=O)[C@H]13)C(C)(C)C)C(=O)N(CC=C)Cc4ccccc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 A11 compound treatment 379460.0 -74800.0 -0.37 128750.0 -235000.0 -1.11 -1.0472 -0.8959 3561853 PK04_181011 Brc1ccc(CN(C(C(=O)NCc2ccccc2)c3ccco3)C(=O)Cc4ccccc4)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 A12 compound treatment 403050.0 -51200.0 -0.26 171170.0 -193000.0 -0.91 -0.8228 -0.8722 3561854 PK04_181012 CCOC(=O)[C@H]1C2OC3(C=C2)[C@H](N(C(=O)[C@H]13)C(C)(C)C)C(=O)NCc4ccccc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 A13 mock treatment 169820.0 -284000.0 -1.42 157790.0 -206000.0 -0.97 -1.691 -0.9828 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 A14 mock treatment 392320.0 -61900.0 -0.31 367300.0 3070.0 0.01 -0.2084 -0.6734 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 A15 compound treatment 254970.0 -199000.0 -1.0 148800.0 -215000.0 -1.01 -1.4202 -1.0 3561850 PK04_181013 O=C(Cc1ccccc1)N(Cc2ccccc2)C(C(=O)NCc3ccccc3)c4ccccc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 A16 compound treatment 462300.0 8090.0 0.04 273550.0 -90700.0 -0.43 -0.2731 -0.6373 3561856 PK04_181014 C[C@H](C(OC(=O)[C@@H]1[C@H]2O[C@@]3(C=C2)[C@H](CN(CC=C)Cc4ccccc4)N(C(=O)[C@@H]13)C(C)(C)C)c5ccccc5)N(C)C(=O)CCC=C 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 A17 compound treatment 404440.0 -49800.0 -0.25 334480.0 -29800.0 -0.14 -0.2747 -0.9631 3561858 PK04_181015 COc1ccc(CNC(=O)OCC2c3ccccc3-c4ccccc24)cc1OC 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 A18 compound treatment 460060.0 5850.0 0.03 388980.0 24700.0 0.12 0.1029 0.8579 3561856 PK04_181016 C[C@H](C(OC(=O)[C@@H]1[C@H]2O[C@@]3(C=C2)[C@H](CN(CC=C)Cc4ccccc4)N(C(=O)[C@@H]13)C(C)(C)C)c5ccccc5)N(C)C(=O)CCC=C 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 A19 compound treatment 391490.0 -62700.0 -0.31 396070.0 31800.0 0.15 -0.1156 -0.333 3561859 PK04_181017 CCOC(=O)C1C2OC3(C=C2)C(N(Cc4cc(OC)cc(OC)c4)C(=O)C13)C(=O)NCc5ccccc5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 A20 compound treatment 246530.0 -208000.0 -1.04 321870.0 -42400.0 -0.2 -0.8744 -0.8278 3561860 PK04_181018 COc1ccc(CN2[C@H](C(=O)N(CC=C)Cc3ccccc3)C4(OC5C=C4)[C@@H]([C@H]5C(=O)O)C2=O)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 A21 compound treatment 234400.0 -220000.0 -1.1 150270.0 -214000.0 -1.01 -1.4879 -0.9991 3561861 PK04_181019 CCOC(=O)C1C2OC3(C=C2)C(N(Cc4ccccc4)C(=O)C13)C(=O)NCc5ccccc5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 A22 compound treatment 387840.0 -66400.0 -0.33 403460.0 39200.0 0.18 -0.1039 -0.274 3561862 PK04_181020 COc1cc(CN2[C@H](C(=O)N(CC=C)Cc3ccccc3)C4(OC5C=C4)[C@@H]([C@H]5C(=O)O)C2=O)ccc1O[SiH](C(C)C)C(C)C 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 A23 compound treatment 284090.0 -170000.0 -0.85 312580.0 -51700.0 -0.24 -0.7726 -0.8743 3561864 PK04_181021 O=C(Cc1ccccc1)OC(C(=O)NCc2ccccc2)c3ccco3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 A24 compound treatment 202910.0 -251000.0 -1.26 325940.0 -38300.0 -0.18 -1.0149 -0.8004 3561865 PK04_181022 COc1cc(CN2[C@H]3C(=O)N(Cc4ccccc4)C/C=C/CCC(=O)N(C)[C@H](C)[C@H](OC(=O)[C@@H]5[C@H]6O[C@]3(C=C6)[C@H]5C2=O)c7ccccc7)ccc1O[SiH](C(C)C)C(C)C 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 B01 compound treatment 442180.0 -12000.0 -0.06 450190.0 86000.0 0.4 0.2434 0.5954 3561867 PK04_181023 OC(CC=C)c1cccc(c1)[N+](=O)[O-] 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 B02 compound treatment 507120.0 52900.0 0.26 442240.0 78000.0 0.37 0.4463 0.987 1008566 PK04_181024 Cc1cc(c(O)c(c1)C(C)(C)C)C(C)(C)C 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 B03 compound treatment 405480.0 -48700.0 -0.24 293490.0 -70700.0 -0.33 -0.4074 -0.9882 3561868 PK04_181025 CC(C)(C)OC(=O)OC(CC=C)c1ccc(cc1)[N+](=O)[O-] 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 B04 compound treatment 342560.0 -112000.0 -0.56 305600.0 -58600.0 -0.28 -0.5893 -0.9473 3561869 PK04_181026 CC(C)CC1CC(=O)C(=C(Cl)N1C(=O)OC(C)(C)C)[Se]c2ccccc2 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 B05 compound treatment 452980.0 -1230.0 -0.01 303590.0 -60600.0 -0.29 -0.2061 -0.7222 3561870 PK04_181027 OC(CC1CO1)c2ccc(cc2)[N+](=O)[O-] 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 B06 compound treatment 351690.0 -103000.0 -0.51 214080.0 -150000.0 -0.71 -0.8615 -0.9875 3561871 PK04_181028 CC(C)CC1CC(=O)C(=C(Cl)N1C(=O)OC(C)(C)C)Cl 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 B07 compound treatment 365310.0 -88900.0 -0.44 300580.0 -63700.0 -0.3 -0.5257 -0.9816 3561872 PK04_181029 OC(CSc1nc(c(o1)c2ccccc2)c3ccccc3)CC(O)c4ccc(cc4)[N+](=O)[O-] 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 B08 compound treatment 137350.0 -317000.0 -1.58 81050.0 -283000.0 -1.33 -2.0609 -0.9963 3561873 PK04_181030 CC(C)CC1CC(=O)C=C(Cl)N1C(=O)OC(C)(C)C 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 B09 compound treatment 486320.0 32100.0 0.16 381390.0 17200.0 0.08 0.1704 0.9495 3561874 PK04_181031 COC(=O)CCCCCCC(=O)Nc1ccc(cc1)C2OC(CSc3nc(c(o3)c4ccccc4)c5ccccc5)CC(O2)c6ccc(cc6)[N+](=O)[O-] 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 B10 compound treatment 443680.0 -10500.0 -0.05 394370.0 30100.0 0.14 0.063 0.4168 3561875 PK04_181032 COC(=O)C1=C(Cl)N(C(CC(C)C)CC1=O)C(=O)OC(C)(C)C 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 B11 compound treatment 438100.0 -16100.0 -0.08 363360.0 -874.0 0.0 -0.0598 -0.7422 3561876 PK04_181033 OC(=O)CCCCCCC(=O)Nc1ccc(cc1)C2CC(CSc3nc(c(o3)c4ccccc4)c5ccccc5)OC(O2)c6ccccc6 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 B12 compound treatment 130530.0 -324000.0 -1.62 102090.0 -262000.0 -1.23 -2.015 -0.9911 3561877 PK04_181034 COC(=O)C1=C(OC)N(C(CC(C)C)CC1=O)C(=O)OC(C)(C)C 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 B13 mock treatment 459400.0 5190.0 0.03 342940.0 -21300.0 -0.1 -0.0525 -0.5076 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 B14 mock treatment 495650.0 41400.0 0.21 406750.0 42500.0 0.2 0.2877 0.9999 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 B15 compound treatment 288060.0 -166000.0 -0.83 156210.0 -208000.0 -0.98 -1.2787 -0.9966 3561878 PK04_181035 ONC(=O)CCCCCCC(=O)Nc1ccc(cc1)C2CC(CSc3nc(c(o3)c4ccccc4)c5ccccc5)OC(O2)c6ccccc6 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 B16 compound treatment 12050.0 -442000.0 -2.21 8230.0 -356000.0 -1.67 -2.7456 -0.9907 3561879 PK04_181036 CC(C)CC1CC(=O)C(=C(Cl)N1C(=O)OC(C)(C)C)I 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 B17 compound treatment 397950.0 -56300.0 -0.28 356070.0 -8160.0 -0.04 -0.2259 -0.7963 3561880 PK04_181037 OC(CC1CO1)c2ccccc2 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 B18 compound treatment 477380.0 23200.0 0.12 368860.0 4630.0 0.02 0.0972 0.8256 3561881 PK04_181038 CC(C)(C)OC(=O)NCC=C 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 B19 compound treatment 466640.0 12400.0 0.06 397960.0 33700.0 0.16 0.1561 0.9161 3561882 PK04_181039 CN(CC(O)CC(O)c1ccccc1)Cc2ccccc2 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 B20 compound treatment 447160.0 -7050.0 -0.04 355240.0 -8990.0 -0.04 -0.0548 -0.9959 3561883 PK04_181040 COc1ccc(CN(C(=C)C=C)S(=O)(=O)c2ccc(Br)cc2)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 B21 compound treatment 463300.0 9090.0 0.05 406350.0 42100.0 0.2 0.1722 0.8471 3561884 PK04_181041 OC(=O)CCCCCCC(=O)Nc1ccc(cc1)C2OC(CSc3nc(c(o3)c4ccccc4)c5ccccc5)CC(O2)c6ccc(cc6)[N+](=O)[O-] 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 B22 compound treatment 13730.0 -440000.0 -2.2 11240.0 -353000.0 -1.66 -2.7297 -0.9904 3561885 PK04_181042 COc1ccc(CNS(=O)(=O)c2ccc(cc2[N+](=O)[O-])[N+](=O)[O-])c(OC)c1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 B23 compound treatment 471840.0 17600.0 0.09 411210.0 47000.0 0.22 0.2185 0.9186 3561886 PK04_181043 OC(=O)CCCCCCC(=O)Nc1ccc(cc1)C2OC(CSc3ccncc3)CC(O2)c4ccccc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 B24 compound treatment 86050.0 -368000.0 -1.84 57340.0 -307000.0 -1.44 -2.321 -0.9928 3561887 PK04_181044 Brc1ccc(cc1)S(=O)(=O)N2C[C@H]2C=C 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 C01 compound treatment 399550.0 -54700.0 -0.27 270280.0 -94000.0 -0.44 -0.5055 -0.9732 3561889 PK04_181045 O=C(Cc1ccccc1)N2CC(=O)Oc3ccccc23 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 C02 compound treatment 415810.0 -38400.0 -0.19 360830.0 -3400.0 -0.02 -0.147 -0.7635 3561890 PK04_181046 CCCCCNC(=O)[C@H]1N(C(=O)[C@@H]2[C@H](C3OC12C=C3)C(=O)OCC)c4ccccc4Cl 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 C03 compound treatment 335140.0 -119000.0 -0.59 199200.0 -165000.0 -0.78 -0.9694 -0.9913 3561892 PK04_181047 CCOC(=O)C1C2OC3(C=C2)C(N(CCCCCCO)C(=O)C13)C(=O)N(CC=C)Cc4ccccc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 C04 compound treatment 391220.0 -63000.0 -0.31 316550.0 -47700.0 -0.22 -0.3811 -0.9862 2065568 PK04_181048 CCCCCNC(=O)C(OC(=O)c1ccccc1)c2ccco2 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 C05 compound treatment 41360.0 -413000.0 -2.06 89490.0 -275000.0 -1.29 -2.3719 -0.9747 3561893 PK04_181049 OCCCCCCN1C(C(=O)N(CC=C)Cc2ccccc2)C3(OC4C=C3)C(C4C(=O)OCC=C)C1=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 C06 compound treatment 359210.0 -95000.0 -0.47 326520.0 -37700.0 -0.18 -0.461 -0.9099 2065566 PK04_181050 CCCCNC(=O)C(OC(=O)c1ccccc1)c2ccco2 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 C07 compound treatment 389810.0 -64400.0 -0.32 326770.0 -37500.0 -0.18 -0.3521 -0.9599 3561894 PK04_181051 CCOC(=O)C1C2OC3(C=C2)C(N(C4CCC(O)CC4)C(=O)C13)C(=O)N(CC=C)c5ccccc5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 C08 compound treatment 373830.0 -80400.0 -0.4 268670.0 -95600.0 -0.45 -0.6017 -0.9984 2065605 PK04_181052 CC(C)(C)NC(=O)C(OC(=O)c1ccccc1)c2cccs2 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 C09 compound treatment 403640.0 -50600.0 -0.25 260190.0 -104000.0 -0.49 -0.5247 -0.9527 3561895 PK04_181053 O=C(Cc1ccccc1)OC(COCc2ccccc2)C(=O)NCc3ccccc3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 C10 compound treatment 361830.0 -92400.0 -0.46 315000.0 -49200.0 -0.23 -0.49 -0.9492 2065603 PK04_181054 COc1ccc(NC(=O)C(OC(=O)c2ccccc2)c3cccs3)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 C11 mock treatment 303520.0 -151000.0 -0.75 298100.0 -66100.0 -0.31 -0.7522 -0.9236 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 C12 mock treatment 428010.0 -26200.0 -0.13 333410.0 -30800.0 -0.14 -0.1951 -0.9987 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 C13 compound treatment 378510.0 -75700.0 -0.38 321080.0 -43200.0 -0.2 -0.4109 -0.9575 3561896 PK04_181055 CCOC(=O)C1C2OC3(C=C2)C(N(C4CCC(O)CC4)C(=O)C13)C(=O)NCc5ccccc5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 C14 compound treatment 372420.0 -81800.0 -0.41 314900.0 -49300.0 -0.23 -0.453 -0.9641 2065601 PK04_181056 O=C(NCc1ccccc1)C(OC(=O)c2ccccc2)c3cccs3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 C15 mock treatment 376590.0 -77600.0 -0.39 315870.0 -48400.0 -0.23 -0.435 -0.9677 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 C16 mock treatment 421280.0 -32900.0 -0.16 242130.0 -122000.0 -0.57 -0.5224 -0.8745 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 C17 compound treatment 318560.0 -136000.0 -0.68 199940.0 -164000.0 -0.77 -1.0255 -0.9979 3561897 PK04_181057 OC1CCC(CC1)N2C(C(=O)NCc3ccccc3)C4(OC5C=C4)C(C5C(=O)OCC=C)C2=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 C18 compound treatment 380530.0 -73700.0 -0.37 284660.0 -79600.0 -0.37 -0.5249 -1.0 3057099 PK04_181058 O=C(NCc1ccccc1)C(OC(=O)c2ccccc2)c3ccco3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 C19 compound treatment 163560.0 -291000.0 -1.45 195290.0 -169000.0 -0.79 -1.5884 -0.9598 3561892 PK04_181059 CCOC(=O)C1C2OC3(C=C2)C(N(CCCCCCO)C(=O)C13)C(=O)N(CC=C)Cc4ccccc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 C20 compound treatment 361820.0 -92400.0 -0.46 302530.0 -61700.0 -0.29 -0.5315 -0.975 3057100 PK04_181060 COc1ccc(NC(=O)C(OC(=O)c2ccccc2)c3ccco3)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 C21 compound treatment 394080.0 -60100.0 -0.3 346900.0 -17300.0 -0.08 -0.27 -0.8677 3561898 PK04_181061 CC(CO)N1[C@@H]2C(=O)N(Cc3ccccc3)CC=C[C@]42O[C@@H]5/C=C/CCC(=O)N(C)[C@H](C)[C@H](OC(=O)[C@@H]5[C@H]4C1=O)c6ccccc6 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 C22 compound treatment 383940.0 -70300.0 -0.35 285370.0 -78900.0 -0.37 -0.5105 -0.9996 3176076 PK04_181062 CC(C)(C)NC(=O)C(OC(=O)c1ccccc1)c2ccco2 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 C23 compound treatment 399940.0 -54300.0 -0.27 397120.0 32900.0 0.15 -0.0823 -0.2637 3561899 PK04_181063 CC(CO)N1[C@H]2C(=O)N(Cc3ccccc3)C/C=C/CCC(=O)N(C)[C@H](C)[C@H](OC(=O)[C@@H]4[C@H]5O[C@]2(C=C5)[C@H]4C1=O)c6ccccc6 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 C24 compound treatment 332640.0 -122000.0 -0.61 348160.0 -16100.0 -0.08 -0.4828 -0.7891 2065566 PK04_181064 CCCCNC(=O)C(OC(=O)c1ccccc1)c2ccco2 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 D01 compound treatment 462460.0 8250.0 0.04 397870.0 33600.0 0.16 0.141 0.8624 3561900 PK04_181065 COCC1CC(OC(O1)c2ccc(NC(=O)CCCCCCC(=O)O)cc2)c3ccccc3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 D02 compound treatment 471740.0 17500.0 0.09 392800.0 28600.0 0.13 0.1569 0.9784 3561901 PK04_181066 COc1cc(OC)c(CNS(=O)(=O)c2ccc(Br)cc2)c(OC)c1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 D03 compound treatment 470320.0 16100.0 0.08 412550.0 48300.0 0.23 0.2176 0.9025 3561902 PK04_181067 OCCSCC1CC(OC(O1)c2ccc(NC(=O)CCCCCCC(=O)O)cc2)c3ccccc3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 D04 compound treatment 441460.0 -12800.0 -0.06 353070.0 -11200.0 -0.05 -0.0822 -0.9954 3561903 PK04_181068 COc1ccc(CN(C(COC(=O)c2cccc(OC)c2O)C=C)S(=O)(=O)c3ccc(Br)cc3)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 D05 compound treatment 196490.0 -258000.0 -1.29 173670.0 -191000.0 -0.9 -1.544 -0.9844 3215593 PK04_181069 OCCSCC1CC(OC(O1)c2ccc(NC(=O)CCCCCCC(=O)NO)cc2)c3ccccc3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 D06 compound treatment 427600.0 -26600.0 -0.13 247480.0 -117000.0 -0.55 -0.4823 -0.8536 3561904 PK04_181070 COC(=O)C1CC=C(CC1C(=O)OC)N(Cc2ccc(OC)cc2)S(=O)(=O)c3ccc(Br)cc3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 D07 compound treatment 443520.0 -10700.0 -0.05 340920.0 -23300.0 -0.11 -0.1153 -0.9454 3561905 PK04_181071 COC(=O)CCCCCCC(=O)Nc1ccc(cc1)C2OC(CN(C)Cc3ccccc3)CC(O2)c4ccccc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 D08 compound treatment 413570.0 -40600.0 -0.2 332370.0 -31900.0 -0.15 -0.2495 -0.9889 3561906 PK04_181072 COc1ccc(CN([C@H](COC(=O)c2ccc(cc2)[N+](=O)[O-])C=C)S(=O)(=O)c3ccc(Br)cc3)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 D09 compound treatment 429300.0 -24900.0 -0.12 345710.0 -18500.0 -0.09 -0.1496 -0.9848 3561908 PK04_181073 OC(CSc1nc2ccccc2o1)CC(O)c3ccccc3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 D10 compound treatment 306530.0 -148000.0 -0.74 337030.0 -27200.0 -0.13 -0.6121 -0.8176 3561909 PK04_181074 Brc1ccc(cc1)N2C(CN(C2=O)S(=O)(=O)c3ccc(Br)cc3)C=C 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 D11 mock treatment 443040.0 -11200.0 -0.06 366560.0 2330.0 0.01 -0.0317 -0.5579 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 D12 mock treatment 449400.0 -4810.0 -0.02 344330.0 -19900.0 -0.09 -0.0832 -0.8608 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 D13 compound treatment 463260.0 9050.0 0.05 339910.0 -24300.0 -0.11 -0.049 -0.398 3561910 PK04_181075 COC(=O)CCCCCCC(=O)NOCc1ccccc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 D14 compound treatment 268850.0 -185000.0 -0.93 351720.0 -12500.0 -0.06 -0.6963 -0.7505 3561911 PK04_181076 COc1ccc(CN([C@H](CI)C=C)S(=O)(=O)c2ccc(Br)cc2)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 D15 mock treatment 458930.0 4720.0 0.02 373300.0 9070.0 0.04 0.0468 0.9608 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 D16 mock treatment 461130.0 6920.0 0.03 343390.0 -20800.0 -0.1 -0.0449 -0.432 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 D17 compound treatment 423520.0 -30700.0 -0.15 370360.0 6130.0 0.03 -0.088 -0.5643 3561913 PK04_181077 OC(=O)CCCCCCC(=O)NOCc1ccccc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 D18 compound treatment 380490.0 -73700.0 -0.37 178400.0 -186000.0 -0.87 -0.8785 -0.9262 3561914 PK04_181078 COc1ccc(CN(C2=CCC3C(C2)C(=O)N(C)C3=O)S(=O)(=O)c4ccc(Br)cc4)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 D19 compound treatment 478880.0 24700.0 0.12 371610.0 7380.0 0.03 0.1116 0.8723 3561915 PK04_181079 OCc1ccc(NC(=O)CCCCCCC(=O)NOCc2ccccc2)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 D20 compound treatment 312960.0 -141000.0 -0.71 216400.0 -148000.0 -0.7 -0.9906 -1.0 3561916 PK04_181080 COCCCN(CC(O)CO)C[C@]1(O)CCC2[C@]1(C)CCC3[C@@]4(C)CC[C@H](O)C[C@@]54C=C[C@]23C(=C5)C(=O)c6ccc(OC)cc6 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 D21 compound treatment 457440.0 3230.0 0.02 371680.0 7450.0 0.04 0.0362 0.9379 3561917 PK04_181081 O=Cc1ccc(NC(=O)CCCCCCC(=O)NOCc2ccccc2)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 D22 compound treatment 435550.0 -18700.0 -0.09 342400.0 -21800.0 -0.1 -0.1385 -0.9988 3561918 PK04_181082 COCCCN(CC(O)CO)C[C@]1(O)CCC2C3=CC=C4C[C@@H](O)CC[C@]4(C)C3CC[C@@]21C 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 D23 compound treatment 364060.0 -90200.0 -0.45 359170.0 -5060.0 -0.02 -0.3352 -0.7435 3561919 PK04_181083 OC(CN=[N+]=[N-])CC(O)c1ccccc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 D24 compound treatment 346740.0 -107000.0 -0.54 367850.0 3620.0 0.02 -0.3675 -0.6844 3561920 PK04_181084 COCCCN(C[C@]1(O)CCC2C3=CC=C4C[C@@H](O)CC[C@]4(C)C3CC[C@@]21C)C(=O)O[C@H]5C[C@@H](C)CC[C@@H]5C(C)C 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 E01 mock treatment 496500.0 42300.0 0.21 409280.0 45000.0 0.21 0.2992 1.0 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 E02 mock treatment 473680.0 19500.0 0.1 416570.0 52300.0 0.25 0.2428 0.9174 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 E03 compound treatment 470720.0 16500.0 0.08 397670.0 33400.0 0.16 0.1695 0.9546 3561899 PK04_181085 CC(CO)N1[C@H]2C(=O)N(Cc3ccccc3)C/C=C/CCC(=O)N(C)[C@H](C)[C@H](OC(=O)[C@@H]4[C@H]5O[C@]2(C=C5)[C@H]4C1=O)c6ccccc6 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 E04 compound treatment 405120.0 -49100.0 -0.25 333780.0 -30500.0 -0.14 -0.2747 -0.9672 2065568 PK04_181086 CCCCCNC(=O)C(OC(=O)c1ccccc1)c2ccco2 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 E05 compound treatment 472690.0 18500.0 0.09 387490.0 23300.0 0.11 0.1426 0.9964 3561899 PK04_181087 CC(CO)N1[C@H]2C(=O)N(Cc3ccccc3)C/C=C/CCC(=O)N(C)[C@H](C)[C@H](OC(=O)[C@@H]4[C@H]5O[C@]2(C=C5)[C@H]4C1=O)c6ccccc6 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 E06 compound treatment 401340.0 -52900.0 -0.26 326730.0 -37500.0 -0.18 -0.3115 -0.9808 2065570 PK04_181088 O=C(NCc1ccccc1)C(COCc2ccccc2)OC(=O)c3ccccc3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 E07 compound treatment 349650.0 -105000.0 -0.52 237460.0 -127000.0 -0.6 -0.7909 -0.9978 3561899 PK04_181089 CC(CO)N1[C@H]2C(=O)N(Cc3ccccc3)C/C=C/CCC(=O)N(C)[C@H](C)[C@H](OC(=O)[C@@H]4[C@H]5O[C@]2(C=C5)[C@H]4C1=O)c6ccccc6 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 E08 compound treatment 417040.0 -37200.0 -0.19 328270.0 -36000.0 -0.17 -0.2509 -0.9989 2065572 PK04_181090 COc1ccc(NC(=O)C(COCc2ccccc2)OC(=O)c3ccccc3)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 E09 mock treatment 482720.0 28500.0 0.14 373960.0 9730.0 0.05 0.133 0.8895 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 E10 mock treatment 441030.0 -13200.0 -0.07 375940.0 11700.0 0.06 -0.0076 -0.0889 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 E11 compound treatment 215360.0 -239000.0 -1.19 199040.0 -165000.0 -0.78 -1.393 -0.9784 3561921 PK04_181091 COc1ccc(CN2[C@@H](C(=O)N(CC=C)Cc3ccccc3)[C@]4(O[C@H]5C=C4)[C@H]([C@@H]5C(=O)OC([C@@H](C)N(C)C(=O)CCC=C)c6ccccc6)C2=O)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 E12 compound treatment 465440.0 11200.0 0.06 317370.0 -46900.0 -0.22 -0.1162 -0.511 2065574 PK04_181092 CC(C)(C)NC(=O)C(COCc1ccccc1)OC(=O)c2ccccc2 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 E13 compound treatment 414990.0 -39200.0 -0.2 327430.0 -36800.0 -0.17 -0.2609 -0.9981 3561922 PK04_181093 CCOC(=O)[C@@H]1[C@H]2O[C@@]3(C=C2)[C@@H](N(Cc4ccc(OC)cc4)C(=O)[C@@H]13)C(=O)NCc5ccccc5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 E14 compound treatment 380120.0 -74100.0 -0.37 352490.0 -11700.0 -0.06 -0.3007 -0.8037 2065576 PK04_181094 CCCCNC(=O)C(COCc1ccccc1)OC(=O)c2ccccc2 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 E15 compound treatment 478880.0 24700.0 0.12 336900.0 -27300.0 -0.13 -0.0038 -0.0214 3561841 PK04_181095 COc1ccc(CN2[C@@H]3C(=O)N(Cc4ccccc4)CC=C[C@]53O[C@@H]6/C=C/CCC(=O)N(C)[C@H](C)[C@H](OC(=O)[C@@H]6[C@H]5C2=O)c7ccccc7)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 E16 compound treatment 417350.0 -36900.0 -0.18 349010.0 -15200.0 -0.07 -0.1808 -0.9153 2065599 PK04_181096 CCCCCNC(=O)C(COCc1ccccc1)OC(=O)c2ccccc2 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 E17 mock treatment 464100.0 9890.0 0.05 355240.0 -8990.0 -0.04 0.005 0.0769 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 E18 mock treatment 466890.0 12700.0 0.06 317040.0 -47200.0 -0.22 -0.1122 -0.4861 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 E19 compound treatment 441760.0 -12500.0 -0.06 339410.0 -24800.0 -0.12 -0.1265 -0.9565 3561841 PK04_181097 COc1ccc(CN2[C@@H]3C(=O)N(Cc4ccccc4)CC=C[C@]53O[C@@H]6/C=C/CCC(=O)N(C)[C@H](C)[C@H](OC(=O)[C@@H]6[C@H]5C2=O)c7ccccc7)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 E20 compound treatment 432320.0 -21900.0 -0.11 335230.0 -29000.0 -0.14 -0.1738 -0.994 3561923 PK04_181098 CCCNC(=O)COc1ccc(C=O)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 E21 compound treatment 426880.0 -27300.0 -0.14 372850.0 8620.0 0.04 -0.0679 -0.4766 3561841 PK04_181099 COc1ccc(CN2[C@@H]3C(=O)N(Cc4ccccc4)CC=C[C@]53O[C@@H]6/C=C/CCC(=O)N(C)[C@H](C)[C@H](OC(=O)[C@@H]6[C@H]5C2=O)c7ccccc7)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 E22 compound treatment 478580.0 24400.0 0.12 397380.0 33100.0 0.16 0.1963 0.9925 3561924 PK04_181100 CCCNC(=O)Cc1ccc(N)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 E23 compound treatment 441020.0 -13200.0 -0.07 354640.0 -9590.0 -0.05 -0.0785 -0.9829 3561841 PK04_181101 COc1ccc(CN2[C@@H]3C(=O)N(Cc4ccccc4)CC=C[C@]53O[C@@H]6/C=C/CCC(=O)N(C)[C@H](C)[C@H](OC(=O)[C@@H]6[C@H]5C2=O)c7ccccc7)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 E24 compound treatment 469150.0 14900.0 0.07 409820.0 45600.0 0.21 0.2044 0.9002 3561925 PK04_181102 CCOC(=O)/C=C/c1ccccc1OC 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 F01 mock treatment 465760.0 11500.0 0.06 403490.0 39300.0 0.18 0.1713 0.8857 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 F02 mock treatment 439710.0 -14500.0 -0.07 400640.0 36400.0 0.17 0.0699 0.3757 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 F03 compound treatment 402750.0 -51500.0 -0.26 237980.0 -126000.0 -0.59 -0.6017 -0.9298 3561927 PK04_181103 OC(CSc1nc(c(o1)c2ccccc2)c3ccccc3)CC(O)c4ccccc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 F04 compound treatment 355010.0 -99200.0 -0.5 278450.0 -85800.0 -0.4 -0.6357 -0.9948 1366116 PK04_181104 Brc1ccc2ncnc(NCC=C)c2c1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 F05 compound treatment 433460.0 -20800.0 -0.1 375450.0 11200.0 0.05 -0.036 -0.3095 3561928 PK04_181105 CN(CC1CC(OC(O1)c2ccc(NC(=O)CCCCCCC(=O)O)cc2)c3ccccc3)Cc4ccccc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 F06 compound treatment 420060.0 -34200.0 -0.17 325780.0 -38500.0 -0.18 -0.2485 -0.9996 1945167 PK04_181106 C/C(=C/C(=O)c1ccc(Cl)cc1)/Nc2cccc(O)c2 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 F07 compound treatment 459000.0 4790.0 0.02 361630.0 -2600.0 -0.01 0.0082 0.3068 3561929 PK04_181107 OC(CSc1nc2ccccc2s1)CC(O)c3ccccc3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 F08 compound treatment 421070.0 -33100.0 -0.17 365920.0 1690.0 0.01 -0.1114 -0.6725 1448632 PK04_181108 Nn1cnc2-c3ccccc3CC4(CCCC4)c2c1=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 F09 mock treatment 484260.0 30000.0 0.15 394410.0 30200.0 0.14 0.2065 0.9996 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 F10 mock treatment 433700.0 -20500.0 -0.1 377980.0 13700.0 0.06 -0.0267 -0.2206 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 F11 compound treatment 483110.0 28900.0 0.14 327090.0 -37100.0 -0.17 -0.0215 -0.0948 3561930 PK04_181109 OC(CSc1ccccn1)CC(O)c2ccccc2 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 F12 compound treatment 434240.0 -20000.0 -0.1 175640.0 -189000.0 -0.89 -0.6978 -0.7817 3561931 PK04_181110 [O-][N+](=O)c1ccccc1/C=C/c2ccncc2 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 F13 compound treatment 194260.0 -260000.0 -1.3 153400.0 -211000.0 -0.99 -1.6193 -0.9912 3561933 PK04_181111 ONC(=O)CCCCCCC(=O)NOCc1ccccc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 F14 compound treatment 450200.0 -4010.0 -0.02 188440.0 -176000.0 -0.83 -0.5989 -0.724 1679359 PK04_181112 OC(=O)CCCN1C(=O)CSC1=S 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 F15 compound treatment 433810.0 -20400.0 -0.1 340800.0 -23400.0 -0.11 -0.15 -0.9992 1020755 PK04_181113 O=C(C[n+]1ccc2ccccc2c1)c3ccccc3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 F16 compound treatment 437050.0 -17200.0 -0.09 350240.0 -14000.0 -0.07 -0.1072 -0.9915 3561934 PK04_181114 COc1ccc(/C=C/2\SC(=S)N(CCCC(=O)O)C2=O)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 F17 mock treatment 393760.0 -60500.0 -0.3 362950.0 -1280.0 -0.01 -0.2178 -0.7211 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 F18 mock treatment 409780.0 -44400.0 -0.22 292350.0 -71900.0 -0.34 -0.396 -0.9792 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 F19 compound treatment 354600.0 -99600.0 -0.5 303680.0 -60600.0 -0.28 -0.5532 -0.965 3561936 PK04_181115 Brc1c2OCOc2ccc1C[n+]3ccc4ccccc4c3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 F20 compound treatment 129520.0 -325000.0 -1.62 104670.0 -260000.0 -1.22 -2.01 -0.9902 3561937 PK04_181116 COc1ccc(cc1)S(=O)(=O)Nc2ccccc2/C=C/c3ccncc3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 F21 compound treatment 437060.0 -17200.0 -0.09 334690.0 -29500.0 -0.14 -0.1588 -0.973 3561939 PK04_181117 CC(C)(C)[Si](C)(C)Oc1ccc2cc[n+](Cc3ccccc3Br)cc2c1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 F22 compound treatment 401120.0 -53100.0 -0.27 379840.0 15600.0 0.07 -0.1356 -0.4928 1936946 PK04_181118 COc1ccc(/C=C/2\SC(=S)N(CCCC(=O)NC3(CC4CC5CC(C4)C3)C5)C2=O)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 F23 compound treatment 383220.0 -71000.0 -0.35 304650.0 -59600.0 -0.28 -0.4489 -0.9932 3561940 PK04_181119 COc1ccc(Br)c(C[N+]2=Cc3cc(OC)c(OC)cc3CC2)c1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 F24 compound treatment 416230.0 -38000.0 -0.19 395260.0 31000.0 0.15 -0.031 -0.1293 3561941 PK04_181120 COc1cccc(/C=C/2\SC(=S)N(CCCC(=O)O)C2=O)c1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 G01 compound treatment 442080.0 -12100.0 -0.06 377980.0 13700.0 0.06 0.0029 0.0323 3561841 PK04_181121 COc1ccc(CN2[C@@H]3C(=O)N(Cc4ccccc4)CC=C[C@]53O[C@@H]6/C=C/CCC(=O)N(C)[C@H](C)[C@H](OC(=O)[C@@H]6[C@H]5C2=O)c7ccccc7)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 G02 compound treatment 457020.0 2810.0 0.01 363230.0 -1000.0 0.0 0.0066 0.4443 3561943 PK04_181122 O=C1CSC(N1c2ccc(cc2)c3ccccc3)c4ccccc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 G03 mock treatment 444480.0 -9730.0 -0.05 353400.0 -10800.0 -0.05 -0.0704 -0.9997 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 G04 mock treatment 461930.0 7720.0 0.04 395550.0 31300.0 0.15 0.1314 0.863 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 G05 compound treatment 298170.0 -156000.0 -0.78 237130.0 -127000.0 -0.6 -0.9738 -0.9914 PK04_181123 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 G06 compound treatment 438270.0 -15900.0 -0.08 358900.0 -5330.0 -0.03 -0.0741 -0.8869 3561944 PK04_181124 CC(C)(C)c1ccc(cc1)N2C(SCC2=O)c3ccccc3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 G07 compound treatment 426080.0 -28100.0 -0.14 339040.0 -25200.0 -0.12 -0.1832 -0.9964 PK04_181125 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 G08 compound treatment 484490.0 30300.0 0.15 351780.0 -12500.0 -0.06 0.0655 0.4039 3561945 PK04_181126 CCOC(=O)/C=C(\C)/c1ccccc1OC 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 G09 compound treatment 375740.0 -78500.0 -0.39 222750.0 -141000.0 -0.67 -0.7477 -0.9681 3561841 PK04_181127 COc1ccc(CN2[C@@H]3C(=O)N(Cc4ccccc4)CC=C[C@]53O[C@@H]6/C=C/CCC(=O)N(C)[C@H](C)[C@H](OC(=O)[C@@H]6[C@H]5C2=O)c7ccccc7)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 G10 compound treatment 433560.0 -20700.0 -0.1 372510.0 8280.0 0.04 -0.0454 -0.4119 3561947 PK04_181128 CCOC(=O)/C=C/c1c(OC)cccc1OC 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 G11 compound treatment 297540.0 -157000.0 -0.78 286240.0 -78000.0 -0.37 -0.8127 -0.9404 3561899 PK04_181129 CC(CO)N1[C@H]2C(=O)N(Cc3ccccc3)C/C=C/CCC(=O)N(C)[C@H](C)[C@H](OC(=O)[C@@H]4[C@H]5O[C@]2(C=C5)[C@H]4C1=O)c6ccccc6 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 G12 compound treatment 448520.0 -5690.0 -0.03 351800.0 -12400.0 -0.06 -0.0615 -0.9451 3561949 PK04_181130 CCCNC(=O)Cc1ccc(cc1)N2C(SCC2=O)c3ccccc3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 G13 compound treatment 400500.0 -53700.0 -0.27 332480.0 -31800.0 -0.15 -0.2953 -0.9618 3561950 PK04_181131 C[C@@H]1[C@H](OC(=O)[C@@H]2[C@H]3O[C@]4(C=C3)[C@H]2C(=O)N([C@H]4C(=O)N(Cc5ccccc5)C/C=C/CCC(=O)N1C)c6cccc(Cl)c6CO)c7ccccc7 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 G14 compound treatment 423750.0 -30500.0 -0.15 291600.0 -72600.0 -0.34 -0.3492 -0.9336 3561952 PK04_181132 COc1cc(/C=C/CO)cc(OC)c1OC 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 G15 compound treatment 294560.0 -160000.0 -0.8 226500.0 -138000.0 -0.65 -1.0219 -0.9947 3561841 PK04_181133 COc1ccc(CN2[C@@H]3C(=O)N(Cc4ccccc4)CC=C[C@]53O[C@@H]6/C=C/CCC(=O)N(C)[C@H](C)[C@H](OC(=O)[C@@H]6[C@H]5C2=O)c7ccccc7)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 G16 compound treatment 414630.0 -39600.0 -0.2 340110.0 -24100.0 -0.11 -0.22 -0.9653 3561954 PK04_181134 COc1ccccc1/C=C/CO 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 G17 compound treatment 438560.0 -15700.0 -0.08 333990.0 -30200.0 -0.14 -0.1559 -0.9603 3561956 PK04_181135 CCOC(=O)[C@@H]1[C@H]2O[C@@]3(C=C2)[C@@H](N(C(=O)[C@@H]13)c4cccc(Cl)c4CO)C(=O)N(CC=C)Cc5ccccc5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 G18 compound treatment 415890.0 -38300.0 -0.19 226880.0 -137000.0 -0.65 -0.5922 -0.8788 3561958 PK04_181136 O=C1CS(=O)(=O)C(N1c2ccc(cc2)c3ccccc3)c4ccccc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 G19 mock treatment 469540.0 15300.0 0.08 355580.0 -8650.0 -0.04 0.0253 0.2923 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 G20 mock treatment 476800.0 22600.0 0.11 377390.0 13200.0 0.06 0.1235 0.96 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 G21 compound treatment 436560.0 -17700.0 -0.09 349600.0 -14600.0 -0.07 -0.111 -0.9925 3561959 PK04_181137 CC(CO)N1[C@@H](C(=O)N(CC=C)Cc2ccccc2)[C@]3(O[C@H]4C=C3)[C@H]([C@@H]4C(=O)O[C@@H]([C@@H](C)N(C)C(=O)CCC=C)c5ccccc5)C1=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 G22 compound treatment 423470.0 -30700.0 -0.15 210190.0 -154000.0 -0.72 -0.6209 -0.8383 3561961 PK04_181138 CC(C)(C)c1ccc(cc1)N2C(c3ccccc3)S(=O)(=O)CC2=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 G23 compound treatment 309870.0 -144000.0 -0.72 260590.0 -104000.0 -0.49 -0.8545 -0.9818 3561959 PK04_181139 CC(CO)N1[C@@H](C(=O)N(CC=C)Cc2ccccc2)[C@]3(O[C@H]4C=C3)[C@H]([C@@H]4C(=O)O[C@@H]([C@@H](C)N(C)C(=O)CCC=C)c5ccccc5)C1=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 G24 compound treatment 449890.0 -4320.0 -0.02 369120.0 4890.0 0.02 0.001 0.031 2093329 PK04_181140 COC(=O)/C=C/c1cc(OC)c(OC)c(OC)c1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 H01 compound treatment 422660.0 -31600.0 -0.16 409490.0 45300.0 0.21 0.0391 0.1476 3561962 PK04_181141 Brc1ccccc1C(=O)[n+]2ccc3ccccc3c2 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 H02 compound treatment 481440.0 27200.0 0.14 423520.0 59300.0 0.28 0.2933 0.9455 3561963 PK04_181142 COc1ccccc1/C=C/2\SC(=S)N(CCCC(=O)O)C2=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 H03 mock treatment 441640.0 -12600.0 -0.06 401130.0 36900.0 0.17 0.0783 0.4243 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 H04 mock treatment 431440.0 -22800.0 -0.11 388440.0 24200.0 0.11 1.0E-4 5.0E-4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 H05 compound treatment 332230.0 -122000.0 -0.61 298050.0 -66200.0 -0.31 -0.6509 -0.9514 3561965 PK04_181143 COc1cc2CC[N+](=Cc2cc1O[Si](C)(C)C(C)(C)C)Cc3ccccc3Br 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 H06 compound treatment 474890.0 20700.0 0.1 381140.0 16900.0 0.08 0.1292 0.9917 3561966 PK04_181144 COc1cccc(/C=C/2\SC(=S)N(CCCC(=O)NC3(CC4CC5CC(C4)C3)C5)C2=O)c1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 H07 compound treatment 528910.0 74700.0 0.37 427240.0 63000.0 0.3 0.4734 0.9935 3561968 PK04_181145 COc1cc2CC[N+](=Cc2cc1OC)C(=O)c3ccccc3Br 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 H08 compound treatment 481830.0 27600.0 0.14 390560.0 26300.0 0.12 0.1851 0.9986 3561969 PK04_181146 COc1ccc(/C=C/2\SC(=S)N(CCCC(=O)NC3C4CC5CC(C4)CC3C5)C2=O)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 H09 compound treatment 456000.0 1790.0 0.01 330430.0 -33800.0 -0.16 -0.1061 -0.6664 3561971 PK04_181147 Oc1ccc2CCN(Cc3ccccc3Br)C(C=C)c2c1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 H10 compound treatment 393920.0 -60300.0 -0.3 345870.0 -18400.0 -0.09 -0.274 -0.8747 3561972 PK04_181148 COc1ccc(/C=C/2\SC(=S)N(CCCC(=O)NC3(CC4CC5CC(O)(C4)C3)C5)C2=O)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 H11 compound treatment 194130.0 -260000.0 -1.3 290750.0 -73500.0 -0.35 -1.1629 -0.8652 3561974 PK04_181149 Brc1c[n+](Cc2ccccc2)cc3ccccc13 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 H12 compound treatment 433820.0 -20400.0 -0.1 242890.0 -121000.0 -0.57 -0.4756 -0.8203 3561975 PK04_181150 COc1ccc(/C=C/2\SC(=S)N(CCCC(=O)NCC3(CC4CC5CC(C4)C3)C5)C2=O)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 H13 compound treatment 179060.0 -275000.0 -1.37 165070.0 -199000.0 -0.94 -1.6342 -0.9826 3561977 PK04_181151 COc1ccc(Br)c(C[n+]2cc(Br)c3ccccc3c2)c1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 H14 compound treatment 462740.0 8530.0 0.04 216280.0 -148000.0 -0.7 -0.462 -0.6626 3561978 PK04_181152 COc1ccccc1/C=C/2\SC(=S)N(CCCC(=O)NC3(CC4CC5CC(C4)C3)C5)C2=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 H15 compound treatment 496160.0 41900.0 0.21 215720.0 -149000.0 -0.7 -0.3458 -0.4742 1003512 PK04_181153 C[n+]1ccc2ccccc2c1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 H16 compound treatment 149710.0 -305000.0 -1.52 264100.0 -100000.0 -0.47 -1.4084 -0.8846 3561980 PK04_181154 COc1ccc(cc1OC)[C@H]2C[C@H]3C(=C[C@@H]2C(=O)[C@@]43CO4)Br 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 H17 compound treatment 441360.0 -12900.0 -0.06 330040.0 -34200.0 -0.16 -0.1591 -0.9189 1032420 PK04_181155 C(c1ccccc1)[n+]2ccc3ccccc3c2 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 H18 compound treatment 193370.0 -261000.0 -1.3 228390.0 -136000.0 -0.64 -1.373 -0.9462 3561982 PK04_181156 COc1ccc(cc1OC)[C@H]2C[C@H]3C(=C[C@@H]2C(=O)[C@@]43CO4)I 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 H19 mock treatment 326330.0 -128000.0 -0.64 359730.0 -4500.0 -0.02 -0.4666 -0.7302 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 H20 mock treatment 473710.0 19500.0 0.1 393670.0 29400.0 0.14 0.1668 0.9852 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 H21 compound treatment 368930.0 -85300.0 -0.43 340640.0 -23600.0 -0.11 -0.3797 -0.8625 3561984 PK04_181157 COc1ccc(Br)c(C[n+]2ccc3ccccc3c2)c1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 H22 compound treatment 13190.0 -441000.0 -2.2 12530.0 -352000.0 -1.65 -2.7273 -0.99 3561985 PK04_181158 O=C1C=C[C@@H]2[C@@H]3C=C[C@H]([C@@H]2[C@]41CO4)[C@@]5(CO5)C3=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 H23 compound treatment 31150.0 -423000.0 -2.11 29470.0 -335000.0 -1.57 -2.6075 -0.9895 3561987 PK04_181159 COc1ccc(Br)c(C[n+]2ccc3c(cccc3c2)[N+](=O)[O-])c1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 H24 compound treatment 317470.0 -137000.0 -0.68 331740.0 -32500.0 -0.15 -0.591 -0.8445 3561988 PK04_181160 CC1(C)C[C@H]2C[C@H]3C(=C[C@]2(CO1)C(=O)[C@@]43CO4)Br 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 I01 compound treatment 453440.0 -775.0 0.0 355370.0 -8860.0 -0.04 -0.0322 -0.7694 3561956 PK04_181161 CCOC(=O)[C@@H]1[C@H]2O[C@@]3(C=C2)[C@@H](N(C(=O)[C@@H]13)c4cccc(Cl)c4CO)C(=O)N(CC=C)Cc5ccccc5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 I02 compound treatment 439840.0 -14400.0 -0.07 392890.0 28700.0 0.13 0.0445 0.2917 3561990 PK04_181162 CCCNC(=O)Cc1ccc(cc1)N2C(c3ccccc3)S(=O)(=O)CC2=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 I03 compound treatment 446960.0 -7250.0 -0.04 376960.0 12700.0 0.06 0.0167 0.2388 3561991 PK04_181163 OCc1c(Cl)cccc1N2[C@@H](C(=O)N(CC=C)Cc3ccccc3)[C@]4(O[C@H]5C=C4)[C@H]([C@@H]5C(=O)OCC=C)C2=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 I04 compound treatment 427680.0 -26500.0 -0.13 348860.0 -15400.0 -0.07 -0.1448 -0.9594 3561993 PK04_181164 COc1ccccc1/C(=C/CO)/C 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 I05 mock treatment 461690.0 7480.0 0.04 401970.0 37700.0 0.18 0.1519 0.8375 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 I06 mock treatment 393500.0 -60700.0 -0.3 397300.0 33100.0 0.16 -0.1044 -0.3065 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 I07 compound treatment 322240.0 -132000.0 -0.66 319050.0 -45200.0 -0.21 -0.6164 -0.89 3561995 PK04_181165 CCOC(=O)[C@@H]1[C@H]2O[C@@]3(C=C2)[C@@H](N(C(=O)[C@@H]13)C(C)(C)C)C(=O)NCc4ccccc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 I08 compound treatment 466620.0 12400.0 0.06 396000.0 31800.0 0.15 0.1495 0.924 3561996 PK04_181166 COc1ccccc1/C(=C/C=O)/C 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 I09 compound treatment 416640.0 -37600.0 -0.19 339370.0 -24900.0 -0.12 -0.2154 -0.9741 3561998 PK04_181167 OCc1c(Cl)cccc1N2[C@@H](C(=O)NCc3ccccc3)[C@]4(O[C@H]5C=C4)[C@H]([C@@H]5C(=O)O)C2=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 I10 compound treatment 124490.0 -330000.0 -1.65 119290.0 -245000.0 -1.15 -1.9792 -0.9847 2069262 PK04_181168 COc1cc(/C=C/C=O)cc(OC)c1OC 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 I11 compound treatment 462240.0 8030.0 0.04 286510.0 -77700.0 -0.37 -0.2302 -0.6258 3562000 PK04_181169 CCOC(=O)[C@@H]1[C@H]2O[C@@]3(C=C2)[C@@H](N(C(=O)[C@@H]13)c4ccccc4Cl)C(=O)N(CC=C)Cc5ccccc5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 I12 compound treatment 474000.0 19800.0 0.1 376750.0 12500.0 0.06 0.1115 0.9694 3562002 PK04_181170 CCOC(=O)/C=C/c1cccc(c1)[N+](=O)[O-] 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 I13 compound treatment 432480.0 -21700.0 -0.11 327040.0 -37200.0 -0.17 -0.2005 -0.9737 3562003 PK04_181171 C[C@@H]1[C@H](OC(=O)[C@@H]2[C@H]3C(=O)N(Cc4ccccc4)[C@@H]5C(=O)N(Cc6ccccc6)CC=C[C@]35O[C@@H]2/C=C/CCC(=O)N1C)c7ccccc7 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 I14 compound treatment 482240.0 28000.0 0.14 381920.0 17700.0 0.08 0.1578 0.9691 3562005 PK04_181172 COc1cccc(OC)c1/C=C/CO 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 I15 compound treatment 177650.0 -277000.0 -1.38 185880.0 -178000.0 -0.84 -1.5699 -0.9714 3562007 PK04_181173 CCCCNC(=O)[C@@H]1N(C2CCCCC2)C(=O)[C@H]3[C@@H]([C@H]4O[C@@]13C=C4)C(=O)OCC 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 I16 compound treatment 456410.0 2200.0 0.01 258300.0 -106000.0 -0.5 -0.3446 -0.6914 3562009 PK04_181174 Clc1cccc(c1)N2C(SCC2=O)c3ccccc3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 I17 compound treatment 383100.0 -71100.0 -0.36 286520.0 -77700.0 -0.37 -0.5096 -0.9999 3561995 PK04_181175 CCOC(=O)[C@@H]1[C@H]2O[C@@]3(C=C2)[C@@H](N(C(=O)[C@@H]13)C(C)(C)C)C(=O)NCc4ccccc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 I18 compound treatment 480100.0 25900.0 0.13 376010.0 11800.0 0.06 0.1306 0.9284 3065130 PK04_181176 Clc1ccc(cc1)N2C(SCC2=O)c3ccccc3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 I19 compound treatment 475620.0 21400.0 0.11 390510.0 26300.0 0.12 0.163 0.9974 3562010 PK04_181177 C[C@H]([C@H](OC(=O)[C@@H]1[C@H]2O[C@@]3(C=C2)[C@@H](N(C(=O)[C@@H]13)C(C)(C)C)C(=O)N(CC=C)Cc4ccccc4)c5ccccc5)N(C)C(=O)CCC=C 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 I20 compound treatment 419610.0 -34600.0 -0.17 389560.0 25300.0 0.12 -0.038 -0.1809 3562012 PK04_181178 OC/C=C/c1cccc(c1)[N+](=O)[O-] 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 I21 mock treatment 462840.0 8630.0 0.04 363750.0 -484.0 0.0 0.0289 0.6688 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 I22 mock treatment 477170.0 23000.0 0.11 364690.0 456.0 0.0 0.0826 0.7202 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 I23 compound treatment 379910.0 -74300.0 -0.37 357770.0 -6460.0 -0.03 -0.2839 -0.7625 3562014 PK04_181179 C[C@@H]1[C@H](OC(=O)[C@@H]2[C@H]3C(=O)N([C@@H]4C(=O)N(Cc5ccccc5)CC=C[C@]34O[C@@H]2/C=C/CCC(=O)N1C)C(C)(C)C)c6ccccc6 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 I24 compound treatment 392380.0 -61800.0 -0.31 431600.0 67400.0 0.32 0.0057 0.0128 3215604 PK04_181180 O=C/1N(C(c2ccccc2)S(=O)(=O)\C1=C/c3ccc4ccccc4c3)c5ccccc5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 J01 compound treatment 418660.0 -35600.0 -0.18 392800.0 28600.0 0.13 -0.0306 -0.1372 3562016 PK04_181181 COc1ccc(Br)c(C[n+]2ccccc2C)c1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 J02 compound treatment 292540.0 -162000.0 -0.81 211360.0 -153000.0 -0.72 -1.0794 -0.9983 3562017 PK04_181182 OCCCCCCO[C@H]1C[C@H]2C(=C[C@]1(Br)C(=O)[C@@]32CO3)Br 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 J03 compound treatment 376490.0 -77700.0 -0.39 286810.0 -77400.0 -0.36 -0.532 -0.9995 3562019 PK04_181183 COc1ccc(Br)c(C[n+]2ccc3ccccc3c2C)c1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 J04 compound treatment 257600.0 -197000.0 -0.98 224380.0 -140000.0 -0.66 -1.1595 -0.981 3562020 PK04_181184 OCCCCO[C@H]1C[C@H]2C(=C[C@]1(Br)C(=O)[C@@]32CO3)Br 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 J05 mock treatment 448450.0 -5760.0 -0.03 348240.0 -16000.0 -0.08 -0.0736 -0.9131 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 J06 mock treatment 479790.0 25600.0 0.13 363120.0 -1110.0 -0.01 0.0866 0.6775 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 J07 compound treatment 370690.0 -83500.0 -0.42 358210.0 -6020.0 -0.03 -0.315 -0.7534 3562022 PK04_181185 Cc1[n+](Cc2ccccc2)ccc3ccccc13 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 J08 compound treatment 65150.0 -389000.0 -1.94 99790.0 -264000.0 -1.24 -2.2536 -0.9768 3562023 PK04_181186 BrC1=C[C@@]2(Br)[C@H](C[C@@H]1[C@@]3(CO3)C2=O)c4ccccc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 J09 compound treatment 227290.0 -227000.0 -1.13 287110.0 -77100.0 -0.36 -1.0579 -0.889 3562025 PK04_181187 COc1ccc(Br)c(C[n+]2cccc3cc(OC)ccc23)c1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 J10 compound treatment 83040.0 -371000.0 -1.85 67470.0 -297000.0 -1.4 -2.2979 -0.9902 3562026 PK04_181188 COc1ccc(cc1OC)[C@H]2C[C@H]3C(=C[C@]2(Br)C(=O)[C@@]43CO4)Br 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 J11 compound treatment 434630.0 -19600.0 -0.1 329730.0 -34500.0 -0.16 -0.1839 -0.9706 3562028 PK04_181189 COc1ccc(Br)c(C[N+]2=C(C)CCC2)c1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 J12 compound treatment 200990.0 -253000.0 -1.26 144690.0 -220000.0 -1.03 -1.6245 -0.9949 3562029 PK04_181190 COc1ccc(CCNC(=O)[C@]2(CC(=O)N(Cc3ccccc3)[C@@H]2c4ccccc4)c5cc(ccc5F)[N+](=O)[O-])cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 J13 compound treatment 353030.0 -101000.0 -0.51 345150.0 -19100.0 -0.09 -0.4208 -0.8199 3562031 PK04_181191 COc1ccc(Br)c(CN2CCc3cc(OC)c(OC)cc3C2C#Cc4ccccc4)c1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 J14 compound treatment 238250.0 -216000.0 -1.08 208520.0 -156000.0 -0.73 -1.2806 -0.9822 3562032 PK04_181192 COc1ccc(CCNC(=O)[C@@]2(CC(=O)N(Cc3ccccc3)[C@@H]2c4ccccc4)c5cc(ccc5F)[N+](=O)[O-])cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 J15 compound treatment 282180.0 -172000.0 -0.86 321310.0 -42900.0 -0.2 -0.7503 -0.8501 3562033 PK04_181193 COC(CN(Cc1cccc(OC)c1)S(=O)(=O)c2ccc(C)cc2)OC 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 J16 compound treatment 208210.0 -246000.0 -1.23 181360.0 -183000.0 -0.86 -1.477 -0.9848 3562034 PK04_181194 COc1ccc(CCN2C(=O)C3(CC(=O)N(Cc4ccccc4)C3c5ccccc5)c6cc(ccc26)[N+](=O)[O-])cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 J17 compound treatment 269040.0 -185000.0 -0.92 336690.0 -27500.0 -0.13 -0.7456 -0.7984 3562035 PK04_181195 COc1ccc(C[N+]2=Cc3cc(OC)c(OC)cc3CC2)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 J18 compound treatment 449490.0 -4720.0 -0.02 352390.0 -11800.0 -0.06 -0.0561 -0.9269 3562036 PK04_181196 C[C@@]1(CCc2ccccc2)C[C@@H](C[Si](C)(C)C(c3ccccc3)c4ccccc4)OO1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 J19 compound treatment 426880.0 -27300.0 -0.14 389480.0 25200.0 0.12 -0.0126 -0.0695 3562038 PK04_181197 COc1ccc(CN2CCc3cc(OC)c(OC)cc3C2C#Cc4ccccc4)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 J20 compound treatment 424290.0 -29900.0 -0.15 360260.0 -3970.0 -0.02 -0.1189 -0.7894 3562039 PK04_181198 CCCCCCC1C[C@]2(CC[C@@H](CC2)C(C)(C)C)OO1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 J21 mock treatment 468970.0 14800.0 0.07 370610.0 6380.0 0.03 0.0733 0.9215 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 J22 mock treatment 481190.0 27000.0 0.13 389920.0 25700.0 0.12 0.1807 0.9985 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 J23 compound treatment 399070.0 -55100.0 -0.28 357940.0 -6290.0 -0.03 -0.2157 -0.7786 3562041 PK04_181199 COc1cc2CCN(CC=C)C(C#Cc3ccccc3)c2cc1OC 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 J24 compound treatment 484440.0 30200.0 0.15 405500.0 41300.0 0.19 0.244 0.9923 3562042 PK04_181200 Cc1ccc(cc1)C2C[C@]3(CC[C@@H](CC3)C(C)(C)C)OO2 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 K01 compound treatment 486250.0 32000.0 0.16 420390.0 56200.0 0.26 0.2999 0.9712 3562010 PK04_181201 C[C@H]([C@H](OC(=O)[C@@H]1[C@H]2O[C@@]3(C=C2)[C@@H](N(C(=O)[C@@H]13)C(C)(C)C)C(=O)N(CC=C)Cc4ccccc4)c5ccccc5)N(C)C(=O)CCC=C 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 K02 compound treatment 491550.0 37300.0 0.19 387170.0 22900.0 0.11 0.2081 0.9662 3215602 PK04_181202 Cc1c(NC(=O)/C(=C/c2ccc3ccccc3c2)/C#N)c(=O)n(c4ccccc4)n1C 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 K03 compound treatment 378590.0 -75600.0 -0.38 206140.0 -158000.0 -0.74 -0.7929 -0.9507 3562044 PK04_181203 CC(C)(C)N1[C@@H](C(=O)N(CC=C)Cc2ccccc2)[C@]3(O[C@H]4C=C3)[C@H]([C@@H]4C(=O)O)C1=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 K04 compound treatment 436830.0 -17400.0 -0.09 361860.0 -2370.0 -0.01 -0.0693 -0.7915 3562046 PK04_181204 COc1cccc(OC)c1/C=C/C=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 K05 compound treatment 455770.0 1560.0 0.01 274660.0 -89600.0 -0.42 -0.2924 -0.694 2065615 PK04_181205 COc1ccc(CN2[C@H]3C(=O)N(Cc4ccccc4)C/C=C/CCC(=O)N(C)[C@H](C)[C@H](OC(=O)[C@@H]5[C@H]6O[C@]3(C=C6)[C@H]5C2=O)c7ccccc7)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 K06 compound treatment 426970.0 -27200.0 -0.14 374720.0 10500.0 0.05 -0.0613 -0.4238 3562048 PK04_181206 Clc1ccc(cc1)N2C(c3ccccc3)S(=O)(=O)CC2=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 K07 mock treatment 430510.0 -23700.0 -0.12 366410.0 2180.0 0.01 -0.0765 -0.6436 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 K08 mock treatment 497310.0 43100.0 0.22 381120.0 16900.0 0.08 0.2084 0.9082 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 K09 compound treatment 110190.0 -344000.0 -1.72 94650.0 -270000.0 -1.27 -2.1116 -0.9888 3562049 PK04_181207 CC(C)(C)N1[C@@H](C(=O)N(CC=C)Cc2ccccc2)[C@]3(O[C@H]4C=C3)[C@H]([C@@H]4C(=O)OCC=C)C1=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 K10 compound treatment 301350.0 -153000.0 -0.76 306210.0 -58000.0 -0.27 -0.7329 -0.9039 3562051 PK04_181208 Clc1cccc(c1)N2C(c3ccccc3)S(=O)(=O)CC2=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 K11 compound treatment 130260.0 -324000.0 -1.62 102620.0 -262000.0 -1.23 -2.0142 -0.9909 3562052 PK04_181209 CCCCCCN1[C@@H](C(=O)Nc2ccc(OC)cc2)[C@]3(O[C@H]4C=C3)[C@H]([C@@H]4C(=O)OCC)C1=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 K12 compound treatment 361090.0 -93100.0 -0.47 386290.0 22100.0 0.1 -0.2555 -0.5362 3562054 PK04_181210 O=C1CSCN1c2ccccc2 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 K13 compound treatment 303680.0 -151000.0 -0.75 181600.0 -183000.0 -0.86 -1.1391 -0.9978 3562052 PK04_181211 CCCCCCN1[C@@H](C(=O)Nc2ccc(OC)cc2)[C@]3(O[C@H]4C=C3)[C@H]([C@@H]4C(=O)OCC)C1=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 K14 compound treatment 513410.0 59200.0 0.3 408750.0 44500.0 0.21 0.3571 0.9857 1951450 PK04_181212 Cc1c(N2C(SCC2=O)c3ccccc3)c(=O)n(c4ccccc4)n1C 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 K15 mock treatment 413080.0 -41100.0 -0.21 377230.0 13000.0 0.06 -0.102 -0.4761 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 K16 mock treatment 465880.0 11700.0 0.06 388570.0 24300.0 0.11 0.1221 0.9509 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 K17 compound treatment 428710.0 -25500.0 -0.13 369360.0 5130.0 0.02 -0.073 -0.5633 3562052 PK04_181213 CCCCCCN1[C@@H](C(=O)Nc2ccc(OC)cc2)[C@]3(O[C@H]4C=C3)[C@H]([C@@H]4C(=O)OCC)C1=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 K18 compound treatment 487700.0 33500.0 0.17 429410.0 65200.0 0.31 0.335 0.9594 3562055 PK04_181214 CN1C(SCC1=O)c2ccccc2 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 K19 compound treatment 418840.0 -35400.0 -0.18 321220.0 -43000.0 -0.2 -0.268 -0.9977 3562056 PK04_181215 COCOc1ccc2cc(Br)ccc2c1c3c(OCOC)ccc4cc(Br)ccc34 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 K20 compound treatment 491430.0 37200.0 0.19 403700.0 39500.0 0.19 0.2627 1.0 3562057 PK04_181216 O=C1CS(=O)(=O)CN1c2ccccc2 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 K21 compound treatment 441920.0 -12300.0 -0.06 351210.0 -13000.0 -0.06 -0.0867 -1.0 3220192 PK04_181217 CC(CO)N1C2C(=O)N(Cc3ccccc3)CC=CC42OC5C=CCOC(=O)C5C4C1=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 K22 compound treatment 499520.0 45300.0 0.23 402720.0 38500.0 0.18 0.288 0.9939 3562058 PK04_181218 CN1C(c2ccccc2)S(=O)(=O)CC1=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 K23 mock treatment 512030.0 57800.0 0.29 301800.0 -62400.0 -0.29 -0.0035 -0.0084 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 K24 mock treatment 521060.0 66800.0 0.33 440840.0 76600.0 0.36 0.4909 0.9993 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 L01 compound treatment 382460.0 -71800.0 -0.36 326670.0 -37600.0 -0.18 -0.3783 -0.9469 3562059 PK04_181219 COc1cc2CC[N+](=Cc2cc1OC)Cc3ccc(Br)cc3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 L02 compound treatment 479740.0 25500.0 0.13 345620.0 -18600.0 -0.09 0.0282 0.1826 3562060 PK04_181220 CCOC(=O)CCC1(C)C[C@]2(CC[C@@H](CC2)C(C)(C)C)OO1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 L03 compound treatment 313180.0 -141000.0 -0.7 241440.0 -123000.0 -0.58 -0.9065 -0.9951 3562062 PK04_181221 Cc1cc2ccccc2c[n+]1CCCC=C 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 L04 compound treatment 38300.0 -416000.0 -2.08 34300.0 -330000.0 -1.55 -2.5662 -0.9897 3562063 PK04_181222 CC1(CCc2ccccc2)CC(CO)OO1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 L05 compound treatment 121440.0 -333000.0 -1.66 176800.0 -187000.0 -0.88 -1.7986 -0.956 3562064 PK04_181223 COc1ccc(Br)c(C[n+]2cc3ccccc3cc2C)c1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 L06 compound treatment 442880.0 -11300.0 -0.06 327840.0 -36400.0 -0.17 -0.1611 -0.8934 3562065 PK04_181224 CC(C)(C)[C@H]1CC[C@]2(CC(C)(CC(C)(C)CO)OO2)CC1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 L07 mock treatment 450590.0 -3620.0 -0.02 315460.0 -48800.0 -0.23 -0.175 -0.7605 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 L08 mock treatment 450570.0 -3640.0 -0.02 270720.0 -93500.0 -0.44 -0.3239 -0.7357 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 L09 compound treatment 431810.0 -22400.0 -0.11 388480.0 24200.0 0.11 0.0015 0.0095 3562067 PK04_181225 CC1=[N+](C)C2C3CC=CC3C1c4ccccc24 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 L10 compound treatment 133080.0 -321000.0 -1.6 99860.0 -264000.0 -1.24 -2.0134 -0.9921 3562068 PK04_181226 CC(C)(C)[C@H]1CC[C@]2(CC(C)(CCO)OO2)CC1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 L11 compound treatment 476070.0 21900.0 0.11 323680.0 -40600.0 -0.19 -0.0577 -0.2625 1006359 PK04_181227 Cc1cccc[n+]1C 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 L12 compound treatment 247490.0 -207000.0 -1.03 251250.0 -113000.0 -0.53 -1.1059 -0.9523 3562070 PK04_181228 CC1(CCOCc2ccccc2)CC(C)(CCc3ccccc3)OO1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 L13 compound treatment 470310.0 16100.0 0.08 359550.0 -4680.0 -0.02 0.0413 0.4951 3562071 PK04_181229 C[n+]1cc2ccccc2cc1C#N 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 L14 compound treatment 205630.0 -249000.0 -1.24 246190.0 -118000.0 -0.56 -1.2705 -0.9342 3562072 PK04_181230 COc1ccc(CN/2C(C3CC3)c4ccccc4C\C2=N\P(=O)(Oc5ccccc5)Oc6ccccc6)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 L15 mock treatment 492480.0 38300.0 0.19 343290.0 -20900.0 -0.1 0.0655 0.3045 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 L16 mock treatment 457790.0 3580.0 0.02 307680.0 -56600.0 -0.27 -0.1755 -0.6582 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 L17 compound treatment 365410.0 -88800.0 -0.44 282600.0 -81600.0 -0.38 -0.5851 -0.9974 3562074 PK04_181231 CCCCOC1CC2[N+](=C(C)C1c3ccccc23)C 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 L18 compound treatment 470400.0 16200.0 0.08 393470.0 29200.0 0.14 0.1544 0.9679 3562075 PK04_181232 CCCCCCC1C[C@]2(CCC[C@@H](C)C2)OO1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 L19 compound treatment 255450.0 -199000.0 -0.99 274350.0 -89900.0 -0.42 -1.0009 -0.9276 3188663 PK04_181233 COC(=O)[C@H](Cc1ccccc1)N2CC(=C)[C@@H](/C=C/C=C)[C@@H]2[C@@H](O)Cc3ccccc3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 L20 compound treatment 134310.0 -320000.0 -1.6 91130.0 -273000.0 -1.28 -2.0381 -0.9941 3562077 PK04_181234 CC1(CCO)CC(C)(CCc2ccccc2)OO1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 L21 compound treatment 469600.0 15400.0 0.08 418310.0 54100.0 0.25 0.2342 0.8814 3070955 PK04_181235 COC(=O)[C@H](Cc1ccccc1)N2CC(C)(OC)O[C@@H](Cc3ccccc3)[C@H]2/C=C/C4CC4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 L22 compound treatment 56250.0 -398000.0 -1.99 57530.0 -307000.0 -1.44 -2.4256 -0.9876 3562078 PK04_181236 COC(=O)CC1(C)CC(C)(CCc2ccccc2)OO1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 L23 mock treatment 477530.0 23300.0 0.12 421560.0 57300.0 0.27 0.273 0.9295 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 L24 mock treatment 496350.0 42100.0 0.21 442740.0 78500.0 0.37 0.4099 0.9645 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 M01 compound treatment 429770.0 -24400.0 -0.12 350330.0 -13900.0 -0.07 -0.1326 -0.9572 3562079 PK04_181237 CC(C)(C)N1[C@H]2C(=O)N(Cc3ccccc3)C/C=C\COC(=O)[C@@H]4[C@H]5O[C@]2(C=C5)[C@H]4C1=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 M02 compound treatment 232320.0 -222000.0 -1.11 136480.0 -228000.0 -1.07 -1.5412 -0.9999 3562081 PK04_181238 Clc1ccccc1/C=C/C=C\2/C(=O)N(CS2(=O)=O)c3ccccc3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 M03 compound treatment 183900.0 -270000.0 -1.35 88390.0 -276000.0 -1.3 -1.8721 -0.9998 3562049 PK04_181239 CC(C)(C)N1[C@@H](C(=O)N(CC=C)Cc2ccccc2)[C@]3(O[C@H]4C=C3)[C@H]([C@@H]4C(=O)OCC=C)C1=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 M04 compound treatment 20110.0 -434000.0 -2.17 13210.0 -351000.0 -1.65 -2.7006 -0.991 3562083 PK04_181240 CN1C(c2ccccc2)S(=O)(=O)/C(=C\C=C\c3ccccc3Cl)/C1=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 M05 compound treatment 279100.0 -175000.0 -0.87 144100.0 -220000.0 -1.04 -1.3506 -0.9965 3562085 PK04_181241 CCOC(=O)[C@@H]1[C@H]2O[C@@]3(C=C2)[C@@H](N(CCCCCCO)C(=O)[C@@H]13)C(=O)NCc4ccccc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 M06 compound treatment 493220.0 39000.0 0.19 399530.0 35300.0 0.17 0.2551 0.9968 1053847 PK04_181242 O=C1CSC(N1c2ccccc2)c3ccccc3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 M07 compound treatment 396880.0 -57300.0 -0.29 343680.0 -20600.0 -0.1 -0.2708 -0.8961 3562085 PK04_181243 CCOC(=O)[C@@H]1[C@H]2O[C@@]3(C=C2)[C@@H](N(CCCCCCO)C(=O)[C@@H]13)C(=O)NCc4ccccc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 M08 compound treatment 295110.0 -159000.0 -0.79 187840.0 -176000.0 -0.83 -1.1486 -0.9998 3562087 PK04_181244 COc1ccccc1/C=C/C=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 M09 mock treatment 458120.0 3910.0 0.02 387760.0 23500.0 0.11 0.092 0.8191 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 M10 mock treatment 481920.0 27700.0 0.14 403790.0 39600.0 0.19 0.2294 0.9894 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 M11 compound treatment 223400.0 -231000.0 -1.15 298140.0 -66100.0 -0.31 -1.035 -0.8668 3562085 PK04_181245 CCOC(=O)[C@@H]1[C@H]2O[C@@]3(C=C2)[C@@H](N(CCCCCCO)C(=O)[C@@H]13)C(=O)NCc4ccccc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 M12 compound treatment 400100.0 -54100.0 -0.27 407490.0 43300.0 0.2 -0.0472 -0.1397 3562088 PK04_181246 O=C1CS(=O)(=O)C(N1c2ccccc2)c3ccccc3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 M13 mock treatment 506310.0 52100.0 0.26 367360.0 3130.0 0.01 0.1944 0.7459 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 M14 mock treatment 431040.0 -23200.0 -0.12 395330.0 31100.0 0.15 0.0216 0.1157 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 M15 compound treatment 130910.0 -323000.0 -1.61 106720.0 -258000.0 -1.21 -1.9983 -0.99 3562089 PK04_181247 CCCCCNC(=O)[C@@H]1N(C(=O)[C@H]2[C@@H]([C@H]3O[C@@]12C=C3)C(=O)OCC)c4ccccc4Cl 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 M16 compound treatment 46880.0 -407000.0 -2.03 38960.0 -325000.0 -1.53 -2.5204 -0.9901 2118235 PK04_181248 [O-][N+](=O)c1cccc(/C=C/C=O)c1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 M17 compound treatment 246850.0 -207000.0 -1.04 240160.0 -124000.0 -0.58 -1.145 -0.9632 3562089 PK04_181249 CCCCCNC(=O)[C@@H]1N(C(=O)[C@H]2[C@@H]([C@H]3O[C@@]12C=C3)C(=O)OCC)c4ccccc4Cl 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 M18 compound treatment 383080.0 -71100.0 -0.36 310020.0 -54200.0 -0.26 -0.4315 -0.9868 3562090 PK04_181250 CC(C)Cc1ccc(/C=C/C=O)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 M19 compound treatment 200840.0 -253000.0 -1.27 197760.0 -166000.0 -0.78 -1.4485 -0.9734 3561852 PK04_181251 CCOC(=O)C1C2OC3(C=C2)C(N(C(=O)C13)C(C)(C)C)C(=O)N(CC=C)Cc4ccccc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 M20 compound treatment 105540.0 -349000.0 -1.74 168480.0 -196000.0 -0.92 -1.8825 -0.9556 3215597 PK04_181252 COc1ccccc1/C=C/C=C\2/C(=O)N(C(c3cccc(c3)[N+](=O)[O-])S2(=O)=O)c4cc(C)cc(C)c4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 M21 compound treatment 336100.0 -118000.0 -0.59 318630.0 -45600.0 -0.21 -0.5688 -0.9062 3562092 PK04_181253 O=C1C2C3C(OC42C=CCN(Cc5ccccc5)C(=O)C4N1C6CCCCC6)C=CCOC3=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 M22 compound treatment 470120.0 15900.0 0.08 398580.0 34300.0 0.16 0.1704 0.9466 3562093 PK04_181254 CCOc1ccc(cc1)N2C(c3ccccc3)S(=O)(=O)CC2=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 M23 compound treatment 162310.0 -292000.0 -1.46 184730.0 -180000.0 -0.84 -1.6279 -0.9663 3562094 PK04_181255 O=C1C2C3C4OC2(C=C4)C(N1C5CCCCC5)C(=O)N(Cc6ccccc6)CCCCOC3=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 M24 compound treatment 497060.0 42800.0 0.21 445010.0 80800.0 0.38 0.42 0.9631 3562095 PK04_181256 Cc1cc(C)cc(c1)N2C(c3ccccc3)S(=O)(=O)CC2=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 N01 compound treatment 435390.0 -18800.0 -0.09 390890.0 26700.0 0.13 0.0222 0.1415 3188533 PK04_181257 O=C1O[C@@H](Cc2ccccc2)[C@@H](/C=C/C3CC3)N(CC#C)[C@H]1Cc4ccccc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 N02 compound treatment 510510.0 56300.0 0.28 407800.0 43600.0 0.2 0.3437 0.9879 3562096 PK04_181258 CC1(CCc2ccccc2)CC(C)(CC(=O)O)OO1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 N03 compound treatment 341860.0 -112000.0 -0.56 252860.0 -111000.0 -0.52 -0.7672 -0.9994 3562097 PK04_181259 C=C/C=C/[C@H]1[C@@H]2[C@H](Cc3ccccc3)OC(=O)[C@H](Cc4ccccc4)N2CC1=C 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 N04 compound treatment 394940.0 -59300.0 -0.3 309380.0 -54900.0 -0.26 -0.3918 -0.9977 3562099 PK04_181260 CC1(CCOCc2ccccc2)CC(C)(COCc3ccccc3)OO1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 N05 compound treatment 322520.0 -132000.0 -0.66 351290.0 -12900.0 -0.06 -0.5082 -0.7693 3562100 PK04_181261 Cn1c(=O)n2[C@H]3[C@@H]4[C@H](Cc5ccccc5)OC(=O)[C@H](Cc6ccccc6)N4CC3=C[C@@H](C7CC7)n2c1=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 N06 compound treatment 522890.0 68700.0 0.34 376800.0 12600.0 0.06 0.2843 0.8169 3562102 PK04_181262 C[C@@H]1CCC[C@]2(CC(C)(CCOCc3ccccc3)OO2)C1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 N07 compound treatment 254750.0 -199000.0 -1.0 203230.0 -161000.0 -0.76 -1.2399 -0.9908 3562104 PK04_181263 O=C1O[C@@H](Cc2ccccc2)[C@H]3[C@@H]4C=CCCC=C4CN3[C@H]1Cc5ccccc5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 N08 compound treatment 466500.0 12300.0 0.06 398600.0 34400.0 0.16 0.1577 0.912 3562106 PK04_181264 CC1(C)O[C@]2(C)CC[C@@H]1OO2 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 N09 mock treatment 460990.0 6780.0 0.03 383700.0 19500.0 0.09 0.0887 0.9084 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 N10 mock treatment 441550.0 -12700.0 -0.06 384170.0 19900.0 0.09 0.0216 0.1908 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 N11 compound treatment 397840.0 -56400.0 -0.28 383650.0 19400.0 0.09 -0.1345 -0.4544 3188666 PK04_181265 COC(=O)[C@H](Cc1ccccc1)N2CC3=C[C@@H](C4CC4)n5n([C@H]3[C@@H]2[C@@H](O)Cc6ccccc6)c(=O)n(C)c5=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 N12 compound treatment 471240.0 17000.0 0.09 396430.0 32200.0 0.15 0.1672 0.9628 3562108 PK04_181266 CC[C@]1(CC[C@@H]2OO1)OC2(C)C 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 N13 mock treatment 469960.0 15700.0 0.08 387280.0 23000.0 0.11 0.1323 0.9876 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 N14 mock treatment 499940.0 45700.0 0.23 388800.0 24600.0 0.12 0.2432 0.9502 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 N15 compound treatment 445860.0 -8350.0 -0.04 263270.0 -101000.0 -0.47 -0.3653 -0.7663 3188536 PK04_181267 O=C1O[C@H](Cc2ccccc2)[C@H](/C=C/C3CC3)N(CC#C)[C@H]1Cc4ccccc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 N16 compound treatment 470680.0 16500.0 0.08 386690.0 22500.0 0.11 0.1328 0.9923 3562110 PK04_181268 CCC[C@]1(CC[C@@H]2OO1)OC2(C)C 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 N17 compound treatment 485280.0 31100.0 0.16 348030.0 -16200.0 -0.08 0.0558 0.3229 3188535 PK04_181269 COC(=O)[C@H](Cc1ccccc1)N2CC(=C)[C@H](/C=C/C=C)[C@H]2[C@H](O)Cc3ccccc3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 N18 compound treatment 452960.0 -1250.0 -0.01 372380.0 8150.0 0.04 0.0227 0.5837 3562112 PK04_181270 CC1(C)O[C@]2(CCc3ccccc3)CC[C@@H]1OO2 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 N19 compound treatment 309140.0 -145000.0 -0.72 345620.0 -18600.0 -0.09 -0.5743 -0.7868 3070940 PK04_181271 COC(=O)[C@H](Cc1ccccc1)N2CC(=C[C@H]2[C@H](O)Cc3ccccc3)/C=C/C4CC4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 N20 compound treatment 147560.0 -307000.0 -1.53 137400.0 -227000.0 -1.07 -1.8374 -0.9844 3562114 PK04_181272 ONC(=O)CCCCCCC(=O)Nc1ccc(cc1)C2OC(CSc3nc(c(o3)c4ccccc4)c5ccccc5)CC(O2)c6ccccc6 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 N21 compound treatment 145090.0 -309000.0 -1.54 155260.0 -209000.0 -0.98 -1.7868 -0.9762 3188534 PK04_181273 COC(=O)[C@H](Cc1ccccc1)N2CC3=CCCC=C[C@@H]3[C@H]2[C@H](O)Cc4ccccc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 N22 compound treatment 376640.0 -77600.0 -0.39 419310.0 55100.0 0.26 -0.0908 -0.1948 3562115 PK04_181274 CC(C)(C)[C@H]1CC[C@]2(CC(C[Si](C)(C)C)OO2)CC1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 N23 compound treatment 450170.0 -4040.0 -0.02 368650.0 4420.0 0.02 4.0E-4 0.0139 3562117 PK04_181275 COC(=O)[C@H](Cc1ccccc1)N2CC3=C[C@H](C4CC4)n5n([C@@H]3[C@H]2[C@H](O)Cc6ccccc6)c(=O)n(C)c5=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 N24 compound treatment 476200.0 22000.0 0.11 437050.0 72800.0 0.34 0.3198 0.8892 1004341 PK04_181276 c1ccc2cnccc2c1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 O01 compound treatment 443600.0 -10600.0 -0.05 412720.0 48500.0 0.23 0.1238 0.5286 3562118 PK04_181277 CCOC(=O)[C@H]1C2OC3(C=C2)[C@H](N(C(=O)[C@H]13)c4cccc(Cl)c4CO)C(=O)NCc5ccccc5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 O02 compound treatment 182560.0 -272000.0 -1.36 142050.0 -222000.0 -1.05 -1.6984 -0.9917 3562120 PK04_181278 CCOc1ccc(cc1)N2C(c3ccccc3)S(=O)(=O)/C(=C\C=C\c4ccccc4OC)/C2=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 O03 compound treatment 327530.0 -127000.0 -0.63 310440.0 -53800.0 -0.25 -0.6263 -0.9191 3562122 PK04_181279 C[C@@H]1[C@H](OC(=O)[C@@H]2[C@H]3O[C@]4(C=C3)[C@H]2C(=O)N([C@H]4C(=O)N(Cc5ccccc5)C/C=C/CCC(=O)N1C)C(C)(C)C)c6ccccc6 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 O04 compound treatment 123390.0 -331000.0 -1.65 71470.0 -293000.0 -1.38 -2.1421 -0.9959 3562124 PK04_181280 COc1ccccc1/C=C/C=C\2/C(=O)N(C(c3cccc(c3)[N+](=O)[O-])S2(=O)=O)c4ccccc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 O05 compound treatment 466330.0 12100.0 0.06 412400.0 48200.0 0.23 0.203 0.8656 3562122 PK04_181281 C[C@@H]1[C@H](OC(=O)[C@@H]2[C@H]3O[C@]4(C=C3)[C@H]2C(=O)N([C@H]4C(=O)N(Cc5ccccc5)C/C=C/CCC(=O)N1C)C(C)(C)C)c6ccccc6 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 O06 compound treatment 161930.0 -292000.0 -1.46 113820.0 -250000.0 -1.18 -1.8651 -0.9943 3562126 PK04_181282 COc1ccccc1/C=C/C=C\2/C(=O)N(C(c3ccccc3)S2(=O)=O)c4cc(C)cc(C)c4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 O07 compound treatment 93000.0 -361000.0 -1.8 103850.0 -260000.0 -1.22 -2.1417 -0.9822 3562128 PK04_181283 CCCCN1CC=C[C@@]23O[C@@H]4/C=C/CCC(=O)N(C)[C@H](C)[C@H](OC(=O)[C@@H]4[C@H]3C(=O)N([C@@H]2C1=O)C(C)(C)C)c5ccccc5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 O08 compound treatment 117690.0 -337000.0 -1.68 74260.0 -290000.0 -1.36 -2.1529 -0.9946 3215600 PK04_181284 COc1ccccc1/C=C/C=C\2/C(=O)N(C(c3ccccc3)S2(=O)=O)c4ccccc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 O09 compound treatment 61930.0 -392000.0 -1.96 74370.0 -290000.0 -1.36 -2.3495 -0.9843 3562128 PK04_181285 CCCCN1CC=C[C@@]23O[C@@H]4/C=C/CCC(=O)N(C)[C@H](C)[C@H](OC(=O)[C@@H]4[C@H]3C(=O)N([C@@H]2C1=O)C(C)(C)C)c5ccccc5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 O10 compound treatment 475840.0 21600.0 0.11 393040.0 28800.0 0.14 0.1722 0.9937 3562130 PK04_181286 OCCSCC(O)CC(O)c1ccccc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 O11 mock treatment 458910.0 4700.0 0.02 269070.0 -95200.0 -0.45 -0.2999 -0.6691 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 O12 mock treatment 514210.0 60000.0 0.3 449360.0 85100.0 0.4 0.495 0.9898 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 O13 compound treatment 476490.0 22300.0 0.11 432480.0 68200.0 0.32 0.3057 0.8997 3561848 PK04_181287 CCCCCN1C/C=C/CCC(=O)N(C)[C@H](C)[C@H](OC(=O)[C@@H]2[C@H]3O[C@]4(C=C3)[C@H]2C(=O)N([C@H]4C1=O)c5ccccc5Cl)c6ccccc6 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 O14 compound treatment 475730.0 21500.0 0.11 408760.0 44500.0 0.21 0.2241 0.9519 3562131 PK04_181288 OC(CSc1ccncc1)CC(O)c2ccccc2 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 O15 compound treatment 269120.0 -185000.0 -0.92 348180.0 -16100.0 -0.08 -0.7071 -0.7623 3562132 PK04_181289 C[C@H](C(O)c1ccccc1)N(C)C(=O)CCC=C 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 O16 compound treatment 527700.0 73500.0 0.37 458830.0 94600.0 0.44 0.5741 0.9954 3562134 PK04_181290 COC(=O)CCCCCCC(=O)Nc1ccc(C=O)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 O17 compound treatment 421620.0 -32600.0 -0.16 356570.0 -7660.0 -0.04 -0.1406 -0.8433 3562132 PK04_181291 C[C@H](C(O)c1ccccc1)N(C)C(=O)CCC=C 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 O18 compound treatment 497920.0 43700.0 0.22 411270.0 47000.0 0.22 0.3108 1.0 3562135 PK04_181292 COC(=O)CCCCCCC(=O)Nc1ccc(cc1)C2OC(CSc3ccccn3)CC(O2)c4ccccc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 O19 compound treatment 210890.0 -243000.0 -1.22 328660.0 -35600.0 -0.17 -0.9777 -0.7969 3561921 PK04_181293 COc1ccc(CN2[C@@H](C(=O)N(CC=C)Cc3ccccc3)[C@]4(O[C@H]5C=C4)[C@H]([C@@H]5C(=O)OC([C@@H](C)N(C)C(=O)CCC=C)c6ccccc6)C2=O)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 O20 compound treatment 486470.0 32300.0 0.16 453890.0 89700.0 0.42 0.4121 0.9129 3562136 PK04_181294 COC(=O)CCCCCCC(=O)Nc1ccc(cc1)C2OC(CSc3nc4ccccc4s3)CC(O2)c5ccccc5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 O21 compound treatment 416040.0 -38200.0 -0.19 264160.0 -100000.0 -0.47 -0.4677 -0.9208 3561921 PK04_181295 COc1ccc(CN2[C@@H](C(=O)N(CC=C)Cc3ccccc3)[C@]4(O[C@H]5C=C4)[C@H]([C@@H]5C(=O)OC([C@@H](C)N(C)C(=O)CCC=C)c6ccccc6)C2=O)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 O22 compound treatment 504220.0 50000.0 0.25 474400.0 110000.0 0.52 0.543 0.944 3562137 PK04_181296 OC(CC=C)c1ccc(cc1)[N+](=O)[O-] 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 O23 compound treatment 526340.0 72100.0 0.36 439040.0 74800.0 0.35 0.5035 0.9999 3561921 PK04_181297 COc1ccc(CN2[C@@H](C(=O)N(CC=C)Cc3ccccc3)[C@]4(O[C@H]5C=C4)[C@H]([C@@H]5C(=O)OC([C@@H](C)N(C)C(=O)CCC=C)c6ccccc6)C2=O)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 O24 compound treatment 437000.0 -17200.0 -0.09 436390.0 72200.0 0.34 0.1792 0.5118 3562138 PK04_181298 CC(C)(C)OC(=O)OC(CC=C)c1ccccc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 P01 compound treatment 289790.0 -164000.0 -0.82 244830.0 -119000.0 -0.56 -0.9778 -0.9828 3562139 PK04_181299 COC(=O)C1(CCCCC1)N2CC3=CCCC=C[C@H]3[C@@H]2[C@@H](O)Cc4ccccc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 P02 compound treatment 478950.0 24700.0 0.12 412060.0 47800.0 0.22 0.2464 0.9602 1015751 PK04_181300 Cc1ccncc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 P03 compound treatment 279470.0 -175000.0 -0.87 359430.0 -4800.0 -0.02 -0.6331 -0.7252 3562141 PK04_181301 COC(=O)[C@@H]1N2[C@H](SC1(C)C)[C@H](N(CC#C)[C@H](/C=C/C3CC3)[C@@H](O)Cc4ccccc4)C2=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 P04 compound treatment 504320.0 50100.0 0.25 454640.0 90400.0 0.43 0.4776 0.968 3562143 PK04_181302 COc1cc2CCN(=Cc2cc1OC)Cl 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 P05 compound treatment 355420.0 -98800.0 -0.49 299940.0 -64300.0 -0.3 -0.5627 -0.9724 3562144 PK04_181303 COC(=O)[C@@H]1N2[C@H](SC1(C)C)[C@H](N3CC4=CCCC=C[C@H]4[C@@H]3[C@@H](O)Cc5ccccc5)C2=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 P06 compound treatment 461170.0 6960.0 0.03 406470.0 42200.0 0.2 0.165 0.8183 1024512 PK04_181304 COc1cc2CCN=C(C)c2cc1OC 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 P07 compound treatment 115810.0 -338000.0 -1.69 168600.0 -196000.0 -0.92 -1.8458 -0.9591 3562146 PK04_181305 O=C1O[C@@H](Cc2ccccc2)[C@H]3[C@@H]4C=CCCC=C4CN3C51CCCCC5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 P08 compound treatment 393000.0 -61200.0 -0.31 392130.0 27900.0 0.13 -0.1234 -0.3709 3562148 PK04_181306 COc1cc2CC(C)N(=Cc2cc1OC)Cl 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 P09 compound treatment 215450.0 -239000.0 -1.19 362410.0 -1820.0 -0.01 -0.8493 -0.7122 3562149 PK04_181307 COC(=O)C1(CCCC1)N(CC#C)[C@H](/C=C/C2CC2)[C@@H](O)Cc3ccccc3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 P10 compound treatment 474440.0 20200.0 0.1 400520.0 36300.0 0.17 0.1921 0.9687 1003512 PK04_181308 C[n+]1ccc2ccccc2c1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 P11 mock treatment 434560.0 -19700.0 -0.1 394310.0 30100.0 0.14 0.0306 0.1778 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 P12 mock treatment 452210.0 -2000.0 -0.01 346400.0 -17800.0 -0.08 -0.0664 -0.7859 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 P13 compound treatment 191050.0 -263000.0 -1.31 271040.0 -93200.0 -0.44 -1.2394 -0.8945 3562151 PK04_181309 COC(=O)[C@@H]1N2[C@H](SC1(C)C)[C@H](N3C[C@](C)(OC)O[C@@H](Cc4ccccc4)[C@H]3/C=C/C5CC5)C2=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 P14 compound treatment 454330.0 115.0 0.0 406800.0 42600.0 0.2 0.142 0.7091 1009497 PK04_181310 Cc1cc[n+](C)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 P15 compound treatment 344390.0 -110000.0 -0.55 151970.0 -212000.0 -1.0 -1.0938 -0.9602 3562153 PK04_181311 COC(=O)[C@@H]1N[C@H](SC1(C)C)[C@@H]2N(CC#C)[C@H](/C=C/C3CC3)[C@H](Cc4ccccc4)OC2=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 P16 compound treatment 409550.0 -44700.0 -0.22 401670.0 37400.0 0.18 -0.0332 -0.1169 1023898 PK04_181312 COc1cc2CC[N+](=Cc2cc1OC)C 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 P17 compound treatment 356330.0 -97900.0 -0.49 199580.0 -165000.0 -0.77 -0.8933 -0.9754 3562155 PK04_181313 COC(=O)[C@@H]1N2[C@H](SC1(C)C)[C@H](N3CC(=C[C@@H]3[C@@H](O)Cc4ccccc4)/C=C/C5CC5)C2=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 P18 compound treatment 416320.0 -37900.0 -0.19 392320.0 28100.0 0.13 -0.0404 -0.1751 1071838 PK04_181314 COc1cc2CC[N+](=C(C)c2cc1OC)C 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 P19 compound treatment 403360.0 -50900.0 -0.25 375060.0 10800.0 0.05 -0.1436 -0.5543 3562157 PK04_181315 O=C1O[C@@H](Cc2ccccc2)[C@@H](/C=C/C3CC3)N(CC#C)C41CCCC4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 P20 compound treatment 415120.0 -39100.0 -0.2 380660.0 16400.0 0.08 -0.0834 -0.3973 1023900 PK04_181316 COc1cc2CC(C)[N+](=Cc2cc1OC)C 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 P21 compound treatment 228180.0 -226000.0 -1.13 232910.0 -131000.0 -0.62 -1.2351 -0.9597 3562159 PK04_181317 COC(=O)[C@@H]1N2[C@H](SC1(C)C)[C@H](N3CC4=C[C@@H](C5CC5)n6n(C4[C@@H]3[C@@H](O)Cc7ccccc7)c(=O)n(C)c6=O)C2=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 P22 compound treatment 401390.0 -52800.0 -0.26 394780.0 30500.0 0.14 -0.085 -0.2828 1107245 PK04_181318 COc1ccc(C[n+]2ccc3ccccc3c2)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 P23 compound treatment 451120.0 -3090.0 -0.02 454030.0 89800.0 0.42 0.2877 0.6808 3562161 PK04_181319 CC(=CCc1cc(/C=C/2\OC(=O)C(=C2O)c3cc4CCC(C)(C)Oc4cc3O)ccc1O)C 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2181 P24 compound treatment 418810.0 -35400.0 -0.18 324480.0 -39800.0 -0.19 -0.2573 -0.9996 3562163 PK04_181320 COc1ccc(C[n+]2ccc(C)cc2)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 A01 compound treatment 245720.0 -237000.0 -1.18 285660.0 -184000.0 -0.87 -1.451 -0.9883 1952677 BCB03_000001 CCCCCCC#Cc1c(C(CC(=O)C)c2ccccc2)c(=O)oc3ccccc13 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 A02 compound treatment 522850.0 40000.0 0.2 568400.0 98300.0 0.46 0.4681 0.9294 3092787 BCB03_000002 CC(C)OC(=O)/C=C\1/C[C@H](O[C@H](O1)c2cccc(c2)C(F)(F)F)c3cccc(c3)C(F)(F)F 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 A03 compound treatment 536320.0 53400.0 0.27 537670.0 67600.0 0.32 0.4135 0.9962 1952679 BCB03_000003 Clc1ccc2oc(=O)cc(Sc3ccccc3)c2c1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 A04 compound treatment 193280.0 -290000.0 -1.45 496010.0 25900.0 0.12 -0.9366 -0.6452 3092788 BCB03_000004 CC(C)OC(=O)/C=C/1\C[C@H](O[C@H](O1)c2ccccc2C(F)(F)F)c3ccccc3C(F)(F)F 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 A05 compound treatment 186590.0 -296000.0 -1.48 207840.0 -262000.0 -1.23 -1.9187 -0.9959 1952690 BCB03_000005 COC(=O)CC(C(=O)OC)c1ccccc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 A06 compound treatment 464980.0 -17900.0 -0.09 155690.0 -314000.0 -1.48 -1.1089 -0.7485 3001175 BCB03_000006 CON(C)C(=O)/C=C/1\C[C@H](O[C@H](O1)c2cccc(Cl)c2)c3cccc(Cl)c3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 A07 compound treatment 522190.0 39300.0 0.2 542150.0 72100.0 0.34 0.3785 0.9663 1952707 BCB03_000007 CCCCSc1cc(=O)oc2cc(OC)ccc12 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 A08 compound treatment 222140.0 -261000.0 -1.3 294580.0 -176000.0 -0.83 -1.5046 -0.9758 3001176 BCB03_000008 CC(C)OC(=O)CC(=O)CC(O)c1ccc(cc1)[N+](=O)[O-] 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 A09 compound treatment 212220.0 -271000.0 -1.35 483840.0 13800.0 0.06 -0.9102 -0.6725 1952793 BCB03_000009 FC(F)(F)c1ccc(cc1)C(=O)Oc2ccccc2C#Cc3ccccc3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 A10 compound treatment 354880.0 -128000.0 -0.64 480200.0 10100.0 0.05 -0.4185 -0.6527 3001249 BCB03_000010 CC(C)OC(=O)CC(=O)CC(O)c1cccc(c1)[N+](=O)[O-] 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 A11 compound treatment 286300.0 -197000.0 -0.98 344730.0 -125000.0 -0.59 -1.1112 -0.9702 1952795 BCB03_000011 COC(=O)/C=C/c1cc(OC)cc(C#Cc2ccc(Oc3ccccc3)c(OC)c2)c1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 A12 compound treatment 471940.0 -11000.0 -0.05 479400.0 9310.0 0.04 -0.0077 -0.1099 3001250 BCB03_000012 CC(C)OC(=O)CC(=O)CC(O)c1cccc(C#N)c1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 A13 mock treatment 378240.0 -105000.0 -0.52 463250.0 -6840.0 -0.03 -0.3923 -0.7492 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 A14 mock treatment 442490.0 -40400.0 -0.2 498610.0 28500.0 0.13 -0.0478 -0.1973 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 A15 compound treatment 440600.0 -42300.0 -0.21 494800.0 24700.0 0.12 -0.0672 -0.2786 1952801 BCB03_000013 Oc1ccccc1C#Cc2ccccc2 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 A16 compound treatment 471700.0 -11200.0 -0.06 489600.0 19500.0 0.09 0.0254 0.2362 3001251 BCB03_000014 CC(C)OC(=O)CC(=O)CC(O)c1ccc(C#N)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 A17 compound treatment 317810.0 -165000.0 -0.82 489940.0 19900.0 0.09 -0.517 -0.623 1952761 BCB03_000015 COc1ccc(cc1)C(=C2C(=O)Oc3ccccc23)c4ccc(OC)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 A18 compound treatment 535430.0 52500.0 0.26 521770.0 51700.0 0.24 0.3574 0.9993 3001252 BCB03_000016 COC(=O)C1=CCC(CC1)(C=C)C(=O)OC 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 A19 compound treatment 296500.0 -186000.0 -0.93 455390.0 -14700.0 -0.07 -0.7071 -0.7575 1952804 BCB03_000017 COc1cc(CO[Si](C)(C)C(C)(C)C)cc(C#CC2(O)CCCCC2)c1O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 A20 compound treatment 316440.0 -166000.0 -0.83 329920.0 -140000.0 -0.66 -1.054 -0.9934 3001253 BCB03_000018 COC(=O)/C=C(/CC(O)c1cccc(Cl)c1)\OC 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 A21 compound treatment 511490.0 28600.0 0.14 336200.0 -134000.0 -0.63 -0.3443 -0.5332 1952805 BCB03_000019 CC(C)(C)[Si](C)(C)OCCNC(=O)c1cc(cc2c(coc12)C(O)(c3ccccc3)c4ccccc4)c5cc(I)cc(I)c5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 A22 compound treatment 247520.0 -235000.0 -1.18 497630.0 27500.0 0.13 -0.7396 -0.6254 3001254 BCB03_000020 OC(C/C(=C/C(=O)OCCF)/OCCF)c1cccc(Cl)c1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 A23 compound treatment 212750.0 -270000.0 -1.35 482240.0 12200.0 0.06 -0.9136 -0.6765 1952808 BCB03_000021 CCCCCc1cc2ccccc2o1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 A24 compound treatment 471570.0 -11300.0 -0.06 190440.0 -280000.0 -1.32 -0.9701 -0.7368 3001255 BCB03_000022 CCO/C(=C\C(=O)OC)/CC(O)c1cccc(Cl)c1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 B01 compound treatment 546880.0 64000.0 0.32 566330.0 96200.0 0.45 0.5461 0.9855 3000770 BCB03_000023 Cc1ccc(cc1)S(=O)(=O)N2C[C@H]([C@@H](C[C@H]2c3ccccc3)Sc4ccccc4)C(=O)O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 B02 compound treatment 197340.0 -286000.0 -1.43 165510.0 -305000.0 -1.43 -2.0215 -1.0 3070361 BCB03_000024 CN1C(=O)C2C(C3C(N(Cc4cccc(OC(F)(F)F)c4)C2C=C3c5ccc(CO)cc5)c6cccs6)C1=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 B03 compound treatment 572190.0 89300.0 0.45 578330.0 108000.0 0.51 0.6754 0.9978 3000771 BCB03_000025 CCOC(=O)C1=C[C@H](N([C@H]1c2ccccc2)S(=O)(=O)c3ccc(C)cc3)c4ccccc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 B04 compound treatment 425450.0 -57400.0 -0.29 491560.0 21500.0 0.1 -0.1314 -0.4322 3189527 BCB03_000026 OCCCC1=CC(C2CC2)N(Cc3cccc(OC(F)(F)F)c3)/C(=N\P(=O)(Oc4ccccc4)Oc5ccccc5)/C1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 B05 compound treatment 569360.0 86500.0 0.43 471860.0 1770.0 0.01 0.3113 0.7206 3092495 BCB03_000027 CCOC(=O)C1=C[C@H](N([C@H]1c2ccc(F)cc2)S(=O)(=O)c3ccc(C)cc3)c4ccccc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 B06 compound treatment 204130.0 -279000.0 -1.39 259840.0 -210000.0 -0.99 -1.6838 -0.986 3189528 BCB03_000028 OCc1ccc(cc1)C2=CC(C3CC3)N(Cc4sc5ccccc5c4Cl)/C(=N\P(=O)(Oc6ccccc6)Oc7ccccc7)/C2 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 B07 compound treatment 559120.0 76200.0 0.38 416360.0 -53700.0 -0.25 0.0905 0.1981 3092496 BCB03_000029 CCOC(=O)C1=C[C@H](N([C@H]1c2ccc(OC)cc2)S(=O)(=O)c3ccc(C)cc3)c4ccccc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 B08 compound treatment 541560.0 58700.0 0.29 569570.0 99500.0 0.47 0.5381 0.9746 3189529 BCB03_000030 CN1C(=O)C2C(C3C(C4CC4)N(C)C2C=C3c5ccc(CO)cc5)C1=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 B09 compound treatment 395360.0 -87500.0 -0.44 368860.0 -101000.0 -0.48 -0.6458 -0.9991 3000773 BCB03_000031 CCOC(=O)C1=C[C@H](N([C@H]1c2cccc(Cl)c2)S(=O)(=O)c3ccc(C)cc3)c4ccccc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 B10 compound treatment 557120.0 74200.0 0.37 528730.0 58600.0 0.28 0.4572 0.9894 3070364 BCB03_000032 CN1C(=O)C2C(C3C(N(C)C2C=C3CCCO)c4ccc(CN5CCCC5)cc4)C1=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 B11 compound treatment 473620.0 -9270.0 -0.05 314240.0 -156000.0 -0.73 -0.5511 -0.7503 3000774 BCB03_000033 CCOC(=O)C1=C[C@H](N([C@H]1c2ccccc2Cl)S(=O)(=O)c3ccc(C)cc3)c4ccccc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 B12 compound treatment 421970.0 -60900.0 -0.3 480350.0 10300.0 0.05 -0.181 -0.5876 3189532 BCB03_000034 CN/1C(C=C(CCCO)C\C1=N\P(=O)(Oc2ccccc2)Oc3ccccc3)c4cccs4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 B13 mock treatment 559460.0 76600.0 0.38 433770.0 -36300.0 -0.17 0.1496 0.3572 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 B14 mock treatment 487200.0 4310.0 0.02 316700.0 -153000.0 -0.72 -0.4949 -0.6857 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 B15 compound treatment 457460.0 -25400.0 -0.13 277990.0 -192000.0 -0.9 -0.7287 -0.7987 3000775 BCB03_000035 CCOC(=O)C1=C[C@H](N([C@H]1c2ccc(C)cc2)S(=O)(=O)c3ccc(C)cc3)C(C)(C)C 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 B16 compound treatment 484500.0 1610.0 0.01 510010.0 39900.0 0.19 0.1385 0.7367 3189533 BCB03_000036 CC1C=C(CCCO)C/C(=N/P(=O)(Oc2ccccc2)Oc3ccccc3)/N1Cc4cccc(OC(F)(F)F)c4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 B17 compound treatment 499040.0 16100.0 0.08 517730.0 47600.0 0.22 0.2155 0.9048 3092507 BCB03_000037 CCOC(=O)C1=C[C@H](N([C@H]1c2ccc(OC)cc2)S(=O)(=O)c3ccc(C)cc3)C(C)(C)C 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 B18 compound treatment 268070.0 -215000.0 -1.07 287440.0 -183000.0 -0.86 -1.3662 -0.9939 3189534 BCB03_000038 CN1C(=O)C2C(C3C(N(Cc4sc5ccccc5c4Cl)C2C=C3CCCO)c6ccc(CN7CCCC7)cc6)C1=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 B19 compound treatment 385310.0 -97600.0 -0.49 554370.0 84300.0 0.4 -0.0643 -0.1023 3092508 BCB03_000039 CCOC(=O)C1=C[C@H](N([C@H]1c2ccc(C#N)cc2)S(=O)(=O)c3ccc(C)cc3)C(C)(C)C 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 B20 compound treatment 296680.0 -186000.0 -0.93 217360.0 -253000.0 -1.19 -1.4982 -0.9926 3070367 BCB03_000040 CC1C2C3C(C(C=C2CCCO)N1Cc4cccc(OC(F)(F)F)c4)C(=O)N(C)C3=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 B21 compound treatment 456160.0 -26700.0 -0.13 512380.0 42300.0 0.2 0.0463 0.1931 3000857 BCB03_000041 CCOC(=O)C1=C[C@H](N([C@H]1c2ccc(F)cc2)S(=O)(=O)c3ccc(C)cc3)C(C)(C)C 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 B22 compound treatment 426030.0 -56900.0 -0.28 467720.0 -2370.0 -0.01 -0.2087 -0.7343 3189537 BCB03_000042 CN1C(=O)C2C(C3C(N(C)C2C=C3c4ccc(CO)cc4)c5cccs5)C1=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 B23 compound treatment 321860.0 -161000.0 -0.8 231840.0 -238000.0 -1.12 -1.3611 -0.9868 3000858 BCB03_000043 CCOC(=O)C1=C[C@H](N([C@H]1c2ccc(Cl)c(Cl)c2)S(=O)(=O)c3ccc(C)cc3)C(C)(C)C 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 B24 compound treatment 393760.0 -89100.0 -0.45 186250.0 -284000.0 -1.34 -1.2588 -0.8945 3189538 BCB03_000044 CN1C(=O)C2C(C3C(C4CC4)N(Cc5sc6ccccc6c5Cl)C2C=C3CCCO)C1=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 C01 compound treatment 517440.0 34500.0 0.17 504000.0 33900.0 0.16 0.2348 0.9992 1952809 BCB03_000045 CC(=O)Oc1ccccc1C#Cc2ccccc2 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 C02 compound treatment 476860.0 -6030.0 -0.03 427100.0 -43000.0 -0.2 -0.1643 -0.8036 3092872 BCB03_000046 FCCOC(=O)C1=CCC(O1)c2cccc(Cl)c2 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 C03 compound treatment 511920.0 29000.0 0.14 554670.0 84600.0 0.4 0.3838 0.9065 1952811 BCB03_000047 CC(C)(C)[Si](C)(C)Oc1ccc(C#C)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 C04 compound treatment 306770.0 -176000.0 -0.88 358240.0 -112000.0 -0.53 -0.994 -0.9698 3000746 BCB03_000048 CC(C)OC(=O)C1=CCC(O1)c2cccc(Cl)c2 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 C05 compound treatment 226800.0 -256000.0 -1.28 405210.0 -64900.0 -0.31 -1.1202 -0.8519 1952813 BCB03_000049 OCCCC#Cc1cc(O)cc(Cl)c1O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 C06 compound treatment 489950.0 7060.0 0.04 489120.0 19000.0 0.09 0.0882 0.917 3000748 BCB03_000050 CCOC(=O)C1=CCC(O1)c2cccc(Cl)c2 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 C07 compound treatment 284750.0 -198000.0 -0.99 448490.0 -21600.0 -0.1 -0.7716 -0.7756 1952814 BCB03_000051 CC(=O)Cc1c(Cl)cc(cc1I)C(=O)NCCO[Si](C)(C)C(C)(C)C 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 C08 compound treatment 341880.0 -141000.0 -0.7 510080.0 40000.0 0.19 -0.365 -0.5007 3000750 BCB03_000052 COC(=O)C1=CCC(O1)c2cccc(Cl)c2 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 C09 compound treatment 501600.0 18700.0 0.09 514580.0 44500.0 0.21 0.2141 0.934 1952821 BCB03_000053 CC(C)(C)[Si](C)(C)COCNC(=O)C1CC2C3C(OC2C(Cl)C1)C4(CCCC4)OC3=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 C10 compound treatment 493570.0 10700.0 0.05 532090.0 62000.0 0.29 0.2439 0.8228 2065163 BCB03_000054 CCOC(=O)/C=C/c1ccccc1O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 C11 mock treatment 489330.0 6440.0 0.03 426900.0 -43200.0 -0.2 -0.1209 -0.5878 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 C12 mock treatment 466470.0 -16400.0 -0.08 472800.0 2710.0 0.01 -0.049 -0.59 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 C13 compound treatment 242740.0 -240000.0 -1.2 285510.0 -185000.0 -0.87 -1.462 -0.9874 1952823 BCB03_000055 C#Cc1ccccc1Oc2ccccc2 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 C14 compound treatment 502490.0 19600.0 0.1 450940.0 -19100.0 -0.09 0.0055 0.0416 3000752 BCB03_000056 CCOC(=O)/C=C/c1cc(F)ccc1O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 C15 mock treatment 299040.0 -184000.0 -0.92 461440.0 -8650.0 -0.04 -0.6781 -0.7377 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 C16 mock treatment 494650.0 11800.0 0.06 457760.0 -12300.0 -0.06 5.0E-4 0.0064 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 C17 compound treatment 315950.0 -167000.0 -0.83 214970.0 -255000.0 -1.2 -1.4381 -0.9842 1952825 BCB03_000057 CCCC(C)(O)C#Cc1cc(cc(C(=O)NCCO[Si](C)(C)C(C)(C)C)c1OC(=O)C)c2cc(F)cc(F)c2 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 C18 compound treatment 425760.0 -57100.0 -0.29 431680.0 -38400.0 -0.18 -0.3295 -0.9757 3000753 BCB03_000058 CCOC(=O)/C=C/c1cc(ccc1O)[N+](=O)[O-] 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 C19 compound treatment 33470.0 -449000.0 -2.24 45600.0 -424000.0 -2.0 -2.999 -0.9983 1952828 BCB03_000059 CCc1cc(OC)c(O)c(C#CC(O)c2ccccc2)c1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 C20 compound treatment 243860.0 -239000.0 -1.19 274680.0 -195000.0 -0.92 -1.4941 -0.9917 3000754 BCB03_000060 CCOC(=O)/C=C/c1cccc(OC)c1O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 C21 compound treatment 428320.0 -54600.0 -0.27 252920.0 -217000.0 -1.02 -0.915 -0.8655 1952829 BCB03_000061 O=C(/C(=C\c1ccccc1)/c2cccc(c2)S(=O)=O)c3ccccc3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 C22 compound treatment 424180.0 -58700.0 -0.29 225690.0 -244000.0 -1.15 -1.0202 -0.8599 3000755 BCB03_000062 CCOC(=O)/C=C/c1cccc(C)c1O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 C23 compound treatment 218640.0 -264000.0 -1.32 213760.0 -256000.0 -1.21 -1.7858 -0.999 1952832 BCB03_000063 CCc1cc(OC)c(O)c(C#CC(C)(O)C=C)c1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 C24 compound treatment 196130.0 -287000.0 -1.43 192490.0 -278000.0 -1.31 -1.936 -0.9989 3000762 BCB03_000064 CCOC(=O)/C=C/c1ccccc1OC(=O)C#CC 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 D01 compound treatment 352930.0 -130000.0 -0.65 347780.0 -122000.0 -0.58 -0.8658 -0.9982 3000859 BCB03_000065 CCOC(=O)C1=C[C@H](N([C@H]1c2cccc(Cl)c2)S(=O)(=O)c3ccc(C)cc3)C(C)(C)C 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 D02 compound treatment 131200.0 -352000.0 -1.76 138280.0 -332000.0 -1.56 -2.3456 -0.9983 3189665 BCB03_000066 OCCCC1=CC(N(Cc2cccc(OC(F)(F)F)c2)/C(=N\P(=O)(Oc3ccccc3)Oc4ccccc4)/C1)c5ccc(CN6CCCC6)cc5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 D03 compound treatment 572270.0 89400.0 0.45 570460.0 100000.0 0.47 0.6495 0.9996 3092513 BCB03_000067 CCOC(=O)C1=C[C@H](N([C@H]1c2ccccc2Cl)S(=O)(=O)c3ccc(C)cc3)C(C)(C)C 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 D04 compound treatment 223600.0 -259000.0 -1.3 370240.0 -99800.0 -0.47 -1.2478 -0.9058 3189666 BCB03_000068 OCCCC1=CC(C2CC2)N(Cc3cc4OCOc4cc3Br)/C(=N\P(=O)(Oc5ccccc5)Oc6ccccc6)/C1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 D05 compound treatment 558770.0 75900.0 0.38 437760.0 -32300.0 -0.15 0.1605 0.393 3092514 BCB03_000069 CCOC(=O)C1=C[C@H](N([C@H]1c2cccc3ccccc23)S(=O)(=O)c4ccc(C)cc4)C(C)(C)C 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 D06 compound treatment 164450.0 -318000.0 -1.59 255290.0 -215000.0 -1.01 -1.839 -0.976 3189668 BCB03_000070 OCCCC1=CC(N(Cc2sc3ccccc3c2Cl)/C(=N\P(=O)(Oc4ccccc4)Oc5ccccc5)/C1)c6ccc(CN7CCCC7)cc6 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 D07 compound treatment 572960.0 90100.0 0.45 249410.0 -221000.0 -1.04 -0.4159 -0.3676 3000861 BCB03_000071 CCOC(=O)C1=C[C@@H](C(C)C)N([C@H]1c2ccc(cc2)C(F)(F)F)S(=O)(=O)c3ccc(C)cc3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 D08 compound treatment 337870.0 -145000.0 -0.72 431560.0 -38500.0 -0.18 -0.6403 -0.8576 3189669 BCB03_000072 CN1C(=O)C2C(C3C(C4CC4)N(Cc5cc6OCOc6cc5Br)C2C=C3CCCO)C1=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 D09 compound treatment 486330.0 3440.0 0.02 396870.0 -73200.0 -0.34 -0.2314 -0.671 3092596 BCB03_000073 CCOC(=O)C1=C[C@@H](C(C)C)N([C@H]1c2ccc(cc2)C(C)C)S(=O)(=O)c3ccc(C)cc3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 D10 compound treatment 526420.0 43500.0 0.22 507970.0 37900.0 0.18 0.2797 0.9951 3189670 BCB03_000074 NC(=O)N1C(=O)C2C(C3C(N(Cc4cc5OCOc5cc4Br)C2C=C3CCCO)c6ccc(CN7CCCC7)cc6)C1=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 D11 mock treatment 546580.0 63700.0 0.32 539160.0 69100.0 0.32 0.4547 0.9999 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 D12 mock treatment 584040.0 101000.0 0.51 387430.0 -82700.0 -0.39 0.0823 0.1291 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 D13 compound treatment 469480.0 -13400.0 -0.07 389990.0 -80100.0 -0.38 -0.3138 -0.82 3000869 BCB03_000075 CCOC(=O)C1=C[C@@H](C(C)C)N([C@H]1c2ccccc2F)S(=O)(=O)c3ccc(C)cc3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 D14 compound treatment 408260.0 -74600.0 -0.37 191650.0 -278000.0 -1.31 -1.1896 -0.8737 3070434 BCB03_000076 NC(=O)N1C(=O)C2C(C3C(N(Cc4sc5ccccc5c4Cl)C2C=C3CCCO)c6ccc(CN7CCCC7)cc6)C1=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 D15 mock treatment 578200.0 95300.0 0.48 540480.0 70400.0 0.33 0.5707 0.9843 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 D16 mock treatment 374110.0 -109000.0 -0.54 384320.0 -85800.0 -0.4 -0.6694 -0.9893 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 D17 compound treatment 472090.0 -10800.0 -0.05 516040.0 46000.0 0.22 0.1147 0.5148 3000870 BCB03_000077 CCOC(=O)C1=C[C@@H](CC)N([C@H]1c2ccccc2)S(=O)(=O)c3ccc(C)cc3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 D18 compound treatment 248000.0 -235000.0 -1.17 408800.0 -61300.0 -0.29 -1.0334 -0.8554 3189673 BCB03_000078 NC(=O)N1C(=O)C2C(C3C(N(Cc4cccc(OC(F)(F)F)c4)C2C=C3CCCO)c5cccs5)C1=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 D19 compound treatment 472260.0 -10600.0 -0.05 387250.0 -82800.0 -0.39 -0.3131 -0.7961 3092599 BCB03_000079 CCOC(=O)C1=CCN(C1c2ccccc2)S(=O)(=O)c3ccc(C)cc3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 D20 compound treatment 255790.0 -227000.0 -1.13 255040.0 -215000.0 -1.01 -1.5173 -0.9984 3189674 BCB03_000080 OCc1ccc(cc1)C2=CC(N(Cc3cccc(OC(F)(F)F)c3)CC2)c4cccs4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 D21 compound treatment 296930.0 -186000.0 -0.93 462330.0 -7760.0 -0.04 -0.6825 -0.7343 3092600 BCB03_000081 CCC[C@@H]1C=C([C@@H](N1S(=O)(=O)c2ccc(C)cc2)c3ccccc3)C(=O)OCC 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 D22 compound treatment 185550.0 -297000.0 -1.49 219960.0 -250000.0 -1.18 -1.882 -0.9933 3070436 BCB03_000082 NC(=O)N1C(=O)C2C(C3C(C4CC4)N(Cc5sc6ccccc6c5Cl)C2C=C3c7ccc(CO)cc7)C1=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 D23 compound treatment 339080.0 -144000.0 -0.72 456720.0 -13400.0 -0.06 -0.5523 -0.7661 3092601 BCB03_000083 CCOC(=O)C1=C[C@H](N([C@H]1c2ccccc2)S(=O)(=O)c3ccc(C)cc3)C(C)(C)C 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 D24 compound treatment 511360.0 28500.0 0.14 421670.0 -48400.0 -0.23 -0.0605 -0.2253 3070437 BCB03_000084 CN1CCC(=CC1C2CC2)CCCO 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 E01 mock treatment 448520.0 -34400.0 -0.17 554120.0 84000.0 0.4 0.1581 0.3669 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 E02 mock treatment 610240.0 127000.0 0.64 580260.0 110000.0 0.52 0.8162 0.9948 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 E03 mock treatment 543580.0 60700.0 0.3 559120.0 89000.0 0.42 0.5105 0.9874 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 E04 compound treatment 553560.0 70700.0 0.35 516890.0 46800.0 0.22 0.4052 0.9742 3093836 BCB03_000085 CCOC(=O)[C@H]1CC=C2[C@@H]1c3ccccc3OC2=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 E05 compound treatment 583010.0 100000.0 0.5 384010.0 -86100.0 -0.4 0.0673 0.1046 1952837 BCB03_000086 COCCNC(=O)c1ccc(c(C#CC(C)(O)CC(C)C)c1O)c2cc(F)cc(F)c2 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 E06 compound treatment 541320.0 58400.0 0.29 397870.0 -72200.0 -0.34 -0.0338 -0.0756 3000764 BCB03_000087 CCOC(=O)[C@H]1CC=C2[C@@H]1c3cc(Br)ccc3OC2=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 E07 compound treatment 406660.0 -76200.0 -0.38 335930.0 -134000.0 -0.63 -0.7154 -0.9707 1952838 BCB03_000088 COc1cc(CO[Si](C)(C)C(C)(C)C)cc(C#CC2(O)CCC3C2CC4Cc5cc(O)ccc5C43)c1O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 E08 compound treatment 522640.0 39700.0 0.2 519640.0 49600.0 0.23 0.3052 0.9968 3000765 BCB03_000089 CCOC(=O)/C=C/c1cc(Br)ccc1OC(=O)C#CC 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 E09 mock treatment 615220.0 132000.0 0.66 550350.0 80300.0 0.38 0.7343 0.9647 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 E10 mock treatment 567840.0 84900.0 0.42 560000.0 89900.0 0.42 0.5991 1.0 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 E11 compound treatment 436640.0 -46300.0 -0.23 484160.0 14100.0 0.07 -0.1165 -0.485 1952839 BCB03_000090 Oc1ccccc1C#CC#Cc2ccccc2O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 E12 compound treatment 211250.0 -272000.0 -1.36 126720.0 -343000.0 -1.62 -2.1014 -0.9962 3000766 BCB03_000091 O=c1oc2ccccc2cc1C#C 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 E13 compound treatment 454400.0 -28500.0 -0.14 342270.0 -128000.0 -0.6 -0.5257 -0.851 1952842 BCB03_000092 COC(=O)Cc1cc(cc(I)c1O)c2cc(F)cc(I)c2 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 E14 compound treatment 553210.0 70300.0 0.35 513120.0 43000.0 0.2 0.3915 0.9657 3000767 BCB03_000093 Cn1c2C3NC(C(=O)c2c4ccccc14)C(C)(C=C3)C(=O)OCc5ccccc5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 E15 compound treatment 326520.0 -156000.0 -0.78 299760.0 -170000.0 -0.8 -1.1188 -0.9999 2065685 BCB03_000094 CCOCOc1cc(O)c(C(=O)/C=C/c2ccccc2)c(OCOCC)c1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 E16 compound treatment 413170.0 -69700.0 -0.35 402040.0 -68000.0 -0.32 -0.4726 -0.9991 3000768 BCB03_000095 [O-][N+](=O)c1ccccc1S(=O)(=O)N2C3CC=C(C2C(=O)c4c3[nH]c5ccccc45)C(=O)OCc6ccccc6 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 E17 mock treatment 532820.0 49900.0 0.25 483470.0 13400.0 0.06 0.2208 0.8587 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 E18 mock treatment 465700.0 -17200.0 -0.09 260960.0 -209000.0 -0.98 -0.7563 -0.7659 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 E19 compound treatment 264010.0 -219000.0 -1.09 385710.0 -84400.0 -0.4 -1.0536 -0.906 2065729 BCB03_000096 CCOCOc1cc(OCOCC)c2C(=O)CC(Oc2c1)c3ccccc3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 E20 compound treatment 426360.0 -56500.0 -0.28 500420.0 30300.0 0.14 -0.0988 -0.3122 3093843 BCB03_000097 CCOC(=O)C1=CC[C@@H]2[C@H]1C(=O)N(C2=O)c3ccccc3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 E21 compound treatment 503580.0 20700.0 0.1 271300.0 -199000.0 -0.94 -0.5881 -0.6252 1952773 BCB03_000098 CCCNC(=O)c1cc(cc2c3C(=O)OC4(CCCC4)c3oc12)c5cc(F)cc(F)c5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 E22 compound treatment 429180.0 -53700.0 -0.27 237310.0 -233000.0 -1.09 -0.9639 -0.8551 3000776 BCB03_000099 CCOC(=O)C1=CC[C@@H]2[C@H]1C(=O)N(CC)C2=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 E23 compound treatment 396810.0 -86100.0 -0.43 219360.0 -251000.0 -1.18 -1.1379 -0.9065 1952780 BCB03_000100 COc1cccc(c1)c2c(oc3ccccc23)c4ccccc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 E24 compound treatment 231680.0 -251000.0 -1.25 350080.0 -120000.0 -0.56 -1.2863 -0.935 3000848 BCB03_000101 CCOC(=O)[C@H]1[C@H](C[C@@H]2[C@H]1C(=O)N(CC)C2=O)Sc3ccccc3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 F01 mock treatment 587700.0 105000.0 0.52 568900.0 98800.0 0.46 0.6988 0.9982 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 F02 mock treatment 580320.0 97400.0 0.49 570450.0 100000.0 0.47 0.6779 0.9999 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 F03 compound treatment 578330.0 95400.0 0.48 538100.0 68000.0 0.32 0.5633 0.9812 3000874 BCB03_000102 Cc1ccc(cc1)[C@@H]2N(CC=C2C(=O)O)S(=O)(=O)c3ccc(C)cc3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 F04 compound treatment 491260.0 8370.0 0.04 459530.0 -10600.0 -0.05 -0.0056 -0.0856 3187712 BCB03_000103 OCCCC1=CC(N(Cc2cc3OCOc3cc2Br)CC1)c4ccc(CN5CCCC5)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 F05 compound treatment 281190.0 -202000.0 -1.01 578300.0 108000.0 0.51 -0.3524 -0.3122 3092602 BCB03_000104 C[C@@H]1C=C([C@@H](N1S(=O)(=O)c2ccc(C)cc2)c3ccc(C)cc3)C(=O)O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 F06 compound treatment 548030.0 65100.0 0.33 365050.0 -105000.0 -0.49 -0.1193 -0.2017 3187713 BCB03_000105 CN1C(C2CC2)C3C4C(C1C=C3c5ccc(CO)cc5)C(=O)N(C(=O)N)C4=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 F07 compound treatment 630370.0 147000.0 0.74 207880.0 -262000.0 -1.23 -0.3513 -0.2445 3092680 BCB03_000106 CC[C@@H]1C=C([C@@H](N1S(=O)(=O)c2ccc(C)cc2)c3ccc(C)cc3)C(=O)O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 F08 compound treatment 567260.0 84400.0 0.42 494340.0 24300.0 0.11 0.3786 0.8673 3187714 BCB03_000107 OCCCC1=CC(C2CC2)N(Cc3cc4OCOc4cc3Br)CC1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 F09 mock treatment 373790.0 -109000.0 -0.54 540700.0 70600.0 0.33 -0.1504 -0.2358 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 F10 mock treatment 565760.0 82900.0 0.41 342570.0 -128000.0 -0.6 -0.1315 -0.1804 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 F11 compound treatment 279430.0 -203000.0 -1.02 544890.0 74800.0 0.35 -0.4698 -0.4368 3092681 BCB03_000108 CCC[C@@H]1C=C([C@@H](N1S(=O)(=O)c2ccc(C)cc2)c3ccc(C)cc3)C(=O)O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 F12 compound treatment 463520.0 -19400.0 -0.1 290630.0 -179000.0 -0.84 -0.6653 -0.783 3070498 BCB03_000109 CC1C=C(CCCO)CCN1Cc2cccc(OC(F)(F)F)c2 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 F13 compound treatment 352610.0 -130000.0 -0.65 399890.0 -70200.0 -0.33 -0.6936 -0.9505 3000959 BCB03_000110 CC(C)[C@@H]1C=C([C@@H](N1S(=O)(=O)c2ccc(C)cc2)c3ccc(C)cc3)C(=O)O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 F14 compound treatment 530160.0 47300.0 0.24 341180.0 -129000.0 -0.61 -0.2618 -0.4024 3070499 BCB03_000111 CN1CCC(=CC1c2cccs2)c3ccc(CO)cc3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 F15 compound treatment 580020.0 97100.0 0.49 519320.0 49200.0 0.23 0.5068 0.9427 3092683 BCB03_000112 Cc1ccc(cc1)[C@@H]2N([C@@H](C=C2C(=O)O)C(C)(C)C)S(=O)(=O)c3ccc(C)cc3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 F16 compound treatment 523920.0 41000.0 0.2 497020.0 26900.0 0.13 0.2345 0.9733 3187718 BCB03_000113 CN1C(C2C3C(C1C=C2CCCO)C(=O)N(C(=O)N)C3=O)c4cccs4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 F17 mock treatment 493350.0 10500.0 0.05 395970.0 -74100.0 -0.35 -0.2096 -0.5945 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 F18 mock treatment 508490.0 25600.0 0.13 501120.0 31000.0 0.15 0.1936 0.9978 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 F19 compound treatment 478520.0 -4370.0 -0.02 463900.0 -6190.0 -0.03 -0.036 -0.99 3092684 BCB03_000114 CC[C@@H]1C=C([C@@H](N1S(=O)(=O)c2ccc(C)cc2)c3ccccc3)C(=O)O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 F20 compound treatment 213720.0 -269000.0 -1.34 199080.0 -271000.0 -1.27 -1.852 -0.9996 3187719 BCB03_000115 OCCCC1=CC(N(Cc2sc3ccccc3c2Cl)CC1)c4ccc(CN5CCCC5)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 F21 compound treatment 400960.0 -81900.0 -0.41 546020.0 75900.0 0.36 -0.0368 -0.0678 3000962 BCB03_000116 CC[C@@H]1C=C([C@@H](N1S(=O)(=O)c2ccc(C)cc2)c3ccc(C#N)cc3)C(=O)O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 F22 compound treatment 141460.0 -341000.0 -1.71 185820.0 -284000.0 -1.34 -2.1513 -0.9928 3187720 BCB03_000117 OCc1ccc(cc1)C2=CC(C3CC3)N(Cc4sc5ccccc5c4Cl)CC2 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 F23 compound treatment 493490.0 10600.0 0.05 464640.0 -5450.0 -0.03 0.0193 0.3284 3092686 BCB03_000118 CC[C@@H]1C=C([C@@H](N1S(=O)(=O)c2ccc(C)cc2)c3ccc(OC)cc3)C(=O)O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 F24 compound treatment 499860.0 17000.0 0.08 450400.0 -19700.0 -0.09 -0.0055 -0.0442 3070502 BCB03_000119 CN1C(C2C3C(C1C=C2c4ccc(CO)cc4)C(=O)N(C(=O)N)C3=O)c5cccs5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 G01 compound treatment 596120.0 113000.0 0.57 553600.0 83500.0 0.39 0.6776 0.9841 3107406 BCB03_000120 COC(=O)/C=C/c1cc(OC)c2oc(c(C)c2c1)c3ccccc3.c1ccsc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 G02 compound treatment 624720.0 142000.0 0.71 592270.0 122000.0 0.57 0.9073 0.9946 3000850 BCB03_000121 OC(=O)C1=CC[C@@H]2[C@H]1C(=O)N(C2=O)c3ccccc3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 G03 mock treatment 610560.0 128000.0 0.64 245180.0 -225000.0 -1.06 -0.2972 -0.2406 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 G04 mock treatment 658960.0 176000.0 0.88 588170.0 118000.0 0.56 1.0146 0.9754 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 G05 compound treatment 208410.0 -274000.0 -1.37 416420.0 -53700.0 -0.25 -1.1479 -0.8235 1952785 BCB03_000122 CCc1cc(OC)c2oc(c(C(=O)c3ccccc3)c2c1)c4ccc(Oc5ccccc5)c(OC)c4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 G06 compound treatment 581860.0 99000.0 0.49 513500.0 43400.0 0.2 0.4939 0.9235 3092501 BCB03_000123 OC(=O)[C@H]1[C@H](C[C@@H]2[C@H]1C(=O)N(C2=O)c3ccccc3)Sc4ccccc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 G07 compound treatment 531640.0 48700.0 0.24 516800.0 46700.0 0.22 0.3275 0.9987 1952788 BCB03_000124 CCc1cc(OC)c2oc(c(C(=O)c3ccc(OC)cc3)c2c1)c4ccc(Oc5ccccc5)c(OC)c4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 G08 compound treatment 340260.0 -143000.0 -0.71 222560.0 -248000.0 -1.16 -1.327 -0.9722 3092502 BCB03_000125 CCOC(=O)C1=CC[C@H](N([C@H]1c2ccccc2)S(=O)(=O)c3ccc(C)cc3)c4ccccc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 G09 compound treatment 405280.0 -77600.0 -0.39 327850.0 -142000.0 -0.67 -0.7472 -0.9663 2065776 BCB03_000126 Cc1ccc(SC2(CC(=O)N(Cc3ccccc3)C2c4ccccc4I)C(=O)NCc5ccccc5)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 G10 compound treatment 570170.0 87300.0 0.44 554810.0 84700.0 0.4 0.59 0.999 3000853 BCB03_000127 CCOC(=O)C1=CC[C@H](N(C1)S(=O)(=O)c2ccc(C)cc2)c3ccccc3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 G11 compound treatment 498330.0 15400.0 0.08 244800.0 -225000.0 -1.06 -0.6948 -0.6539 1034979 BCB03_000128 c1c(cn2ccccc12)c3ccccc3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 G12 compound treatment 442080.0 -40800.0 -0.2 510320.0 40200.0 0.19 -0.0103 -0.0371 3000854 BCB03_000129 CCOC(=O)C1=CC[C@H](N([C@H]1c2cccc(OC)c2)S(=O)(=O)c3ccc(C)cc3)c4ccccc4Cl 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 G13 compound treatment 472360.0 -10500.0 -0.05 520320.0 50200.0 0.24 0.1299 0.5366 2065809 BCB03_000130 COC(=O)Cc1cn[nH]c1C(=O)OC 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 G14 compound treatment 545600.0 62700.0 0.31 228320.0 -242000.0 -1.14 -0.5826 -0.494 3000855 BCB03_000131 CCOC(=O)C1=CCC(N(C1)S(=O)(=O)c2ccc(C)cc2)C(C)(C)C 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 G15 compound treatment 532000.0 49100.0 0.25 452830.0 -17300.0 -0.08 0.116 0.4491 2065826 BCB03_000132 CC(C(=O)O)c1ccccc1C(=O)O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 G16 compound treatment 401600.0 -81300.0 -0.41 238240.0 -232000.0 -1.09 -1.0582 -0.9094 3000862 BCB03_000133 CCOC(=O)C1=CC[C@H](N([C@H]1c2ccccc2C)S(=O)(=O)c3ccc(C)cc3)c4ccccc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 G17 compound treatment 481140.0 -1750.0 -0.01 550720.0 80600.0 0.38 0.262 0.6906 2065840 BCB03_000134 CCOC(=O)CC(CC(=O)OCC)(C(=O)OCC)c1cccnc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 G18 compound treatment 306720.0 -176000.0 -0.88 492900.0 22800.0 0.11 -0.5463 -0.6163 3000863 BCB03_000135 CCOC(=O)C1=CC[C@H](N([C@H]1c2ccccc2)S(=O)(=O)C[Si](C)(C)C)c3ccccc3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 G19 mock treatment 293070.0 -190000.0 -0.95 492350.0 22300.0 0.1 -0.5963 -0.6252 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 G20 mock treatment 201790.0 -281000.0 -1.4 510160.0 40100.0 0.19 -0.8595 -0.6067 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 G21 compound treatment 440960.0 -41900.0 -0.21 486770.0 16700.0 0.08 -0.0926 -0.414 2065855 BCB03_000136 CCOC(=O)CC(C(=O)OCC)c1cccnc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 G22 compound treatment 217560.0 -265000.0 -1.33 207840.0 -262000.0 -1.23 -1.8093 -0.9994 3092589 BCB03_000137 CCOC(=O)C1=CC[C@H](N([C@H]1/C=C/c2ccccc2)S(=O)(=O)c3ccc(C)cc3)c4ccccc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 G23 compound treatment 29790.0 -453000.0 -2.26 24870.0 -445000.0 -2.09 -3.081 -0.9992 2065872 BCB03_000138 CCOC(=O)/C(=C/1\NSc2ccccc12)/C#N 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 G24 compound treatment 287010.0 -196000.0 -0.98 240520.0 -230000.0 -1.08 -1.4553 -0.9988 3092590 BCB03_000139 CCOC(=O)C1=CC[C@H](N([C@H]1c2ccc(C#N)cc2)S(=O)(=O)c3ccc(C)cc3)c4cccc(Cl)c4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 H01 compound treatment 253710.0 -229000.0 -1.14 585340.0 115000.0 0.54 -0.4261 -0.3364 3092687 BCB03_000140 CC[C@@H]1C=C([C@@H](N1S(=O)(=O)c2ccc(C)cc2)c3cccc(Cl)c3)C(=O)O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 H02 compound treatment 404670.0 -78200.0 -0.39 227740.0 -242000.0 -1.14 -1.0823 -0.8982 3187850 BCB03_000141 OCCCC1=CC(C2CC2)N(Cc3cccc(OC(F)(F)F)c3)CC1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 H03 mock treatment 268440.0 -214000.0 -1.07 200240.0 -270000.0 -1.27 -1.6549 -0.9964 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 H04 mock treatment 507950.0 25100.0 0.13 541890.0 71800.0 0.34 0.3273 0.9088 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 H05 compound treatment 356320.0 -127000.0 -0.63 540540.0 70500.0 0.33 -0.2127 -0.298 3092697 BCB03_000142 CC[C@@H]1C=C([C@@H](N1S(=O)(=O)c2ccc(cc2)[N+](=O)[O-])c3ccccc3)C(=O)O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 H06 compound treatment 254600.0 -228000.0 -1.14 564370.0 94300.0 0.44 -0.4927 -0.4027 3187852 BCB03_000143 CN1C(C2C3C(C1C=C2CCCO)C(=O)N(C(=O)N)C3=O)c4ccc(CN5CCCC5)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 H07 compound treatment 360970.0 -122000.0 -0.61 203280.0 -267000.0 -1.25 -1.318 -0.9449 3092698 BCB03_000144 CC[C@@H]1C=C([C@@H](N1S(=O)(=O)c2ccc(C)cc2)c3ccco3)C(=O)O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 H08 compound treatment 281940.0 -201000.0 -1.0 537020.0 66900.0 0.31 -0.4871 -0.4631 3187853 BCB03_000145 CC1C2C3C(C(C=C2CCCO)N1Cc4cccc(OC(F)(F)F)c4)C(=O)N(C(=O)N)C3=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 H09 compound treatment 557210.0 74300.0 0.37 569970.0 99900.0 0.47 0.5947 0.9932 3092699 BCB03_000146 CC[C@@H]1C=C([C@@H](N1S(=O)(=O)c2ccc(C)cc2)c3cccc4ccccc34)C(=O)O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 H10 compound treatment 496720.0 13800.0 0.07 513800.0 43700.0 0.21 0.1942 0.8955 3070552 BCB03_000147 OCCCC1=CC(C2CC2)N(Cc3sc4ccccc4c3Cl)CC1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 H11 compound treatment 167810.0 -315000.0 -1.57 244530.0 -226000.0 -1.06 -1.863 -0.9816 3092700 BCB03_000148 CC[C@@H]1C=C([C@@H](N1S(=O)(=O)c2ccc(C)cc2)c3ccc(Br)cc3)C(=O)O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 H12 compound treatment 531060.0 48200.0 0.24 533230.0 63100.0 0.3 0.3801 0.9945 3070553 BCB03_000149 CN1CCC(=CC1c2cccs2)CCCO 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 H13 compound treatment 281090.0 -202000.0 -1.01 537080.0 67000.0 0.32 -0.4899 -0.4639 3000975 BCB03_000150 CC[C@@H]1C=C([C@@H](N1S(=O)(=O)c2ccc(C)cc2)c3ccc(cc3)C(C)C)C(=O)O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 H14 compound treatment 518490.0 35600.0 0.18 510960.0 40900.0 0.19 0.2617 0.9992 3187856 BCB03_000151 OCCCC1=CC(N(Cc2cccc(OC(F)(F)F)c2)CC1)c3cccs3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 H15 compound treatment 375360.0 -108000.0 -0.54 430740.0 -39300.0 -0.19 -0.5106 -0.8989 3000976 BCB03_000152 Cc1ccc(cc1)S(=O)(=O)N2[C@@H](C=C([C@@H]2c3ccccc3)C(=O)O)C(C)(C)C 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 H16 compound treatment 231650.0 -251000.0 -1.25 502140.0 32100.0 0.15 -0.7807 -0.6177 3187857 BCB03_000153 NC(=O)N1C(=O)C2C(C3C(N(Cc4cccc(OC(F)(F)F)c4)C2C=C3CCCO)c5ccc(CN6CCCC6)cc5)C1=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 H17 compound treatment 601350.0 118000.0 0.59 585440.0 115000.0 0.54 0.802 0.9991 3092773 BCB03_000154 CC(C)[C@@H]1[C@@H](Sc2ccccc2)[C@H]([C@@H](N1S(=O)(=O)c3ccc(C)cc3)c4ccc(C)cc4)C(=O)O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 H18 compound treatment 299370.0 -184000.0 -0.92 184850.0 -285000.0 -1.34 -1.5968 -0.9827 3070555 BCB03_000155 OCc1ccc(cc1)C2=CC(C3CC3)N(Cc4cc5OCOc5cc4Br)CC2 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 H19 mock treatment 441690.0 -41200.0 -0.21 544000.0 73900.0 0.35 0.1003 0.2483 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 H20 mock treatment 493880.0 11000.0 0.05 372590.0 -97500.0 -0.46 -0.2855 -0.6181 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 H21 compound treatment 571140.0 88200.0 0.44 329350.0 -141000.0 -0.66 -0.1564 -0.1967 3092774 BCB03_000156 CC[C@@H]1C(Sc2ccccc2)C([C@@H](N1S(=O)(=O)c3ccc(C)cc3)c4ccc(C)cc4)C(=O)O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 H22 compound treatment 190120.0 -293000.0 -1.46 182750.0 -287000.0 -1.35 -1.9896 -0.9992 3070556 BCB03_000157 NC(=O)N1C(=O)C2C(C3C(C4CC4)N(Cc5sc6ccccc6c5Cl)C2C=C3CCCO)C1=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 H23 compound treatment 355940.0 -127000.0 -0.63 160880.0 -309000.0 -1.45 -1.4768 -0.9308 3092783 BCB03_000158 CCC[C@@H]1[C@@H](Sc2ccccc2)[C@H]([C@@H](N1S(=O)(=O)c3ccc(C)cc3)c4ccc(C)cc4)C(=O)O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 H24 compound treatment 184330.0 -299000.0 -1.49 490430.0 20300.0 0.1 -0.9868 -0.6604 3070597 BCB03_000159 NC(=O)N1C(=O)C2C(C3C(C4CC4)N(Cc5cc6OCOc6cc5Br)C2C=C3c7ccc(CO)cc7)C1=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 I01 compound treatment 530670.0 47800.0 0.24 557330.0 87200.0 0.41 0.4589 0.9667 2065633 BCB03_000160 CCOC(=O)CC(C#N)(C(=O)OCC)c1nsc2ccccc12 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 I02 compound treatment 359460.0 -123000.0 -0.62 609170.0 139000.0 0.65 0.0267 0.0297 3000865 BCB03_000161 CCOC(=O)C1=CC[C@H](N([C@H]1c2ccccc2I)S(=O)(=O)c3ccc(C)cc3)c4ccccc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 I03 compound treatment 620450.0 138000.0 0.69 590290.0 120000.0 0.57 0.8856 0.9953 2065650 BCB03_000162 [O-][N+](=O)c1ccc(OS(=O)(=O)C(F)(F)F)c(I)c1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 I04 compound treatment 231880.0 -251000.0 -1.25 196030.0 -274000.0 -1.29 -1.798 -0.9999 3000866 BCB03_000163 CCOC(=O)C1=CC[C@H](N([C@H]1c2ccc(C#N)cc2)S(=O)(=O)c3ccc(C)cc3)c4ccccc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 I05 mock treatment 540520.0 57600.0 0.29 608530.0 138000.0 0.65 0.664 0.9326 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 I06 mock treatment 590210.0 107000.0 0.54 229240.0 -241000.0 -1.13 -0.422 -0.3368 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 I07 compound treatment 280570.0 -202000.0 -1.01 256820.0 -213000.0 -1.0 -1.4238 -1.0 1065064 BCB03_000164 [O-][N+](=O)c1ccc(CBr)c(I)c1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 I08 compound treatment 515210.0 32300.0 0.16 562330.0 92200.0 0.43 0.4209 0.9093 3000867 BCB03_000165 CCOC(=O)C1=CC[C@H](N([C@H]1c2ccccc2)S(=O)(=O)c3ccc(C)cc3)c4ccccc4F 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 I09 compound treatment 569280.0 86400.0 0.43 596560.0 126000.0 0.59 0.7257 0.9876 2065874 BCB03_000166 COC(=O)C(C(=O)OC)c1ccc(cc1I)[N+](=O)[O-] 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 I10 compound treatment 263970.0 -219000.0 -1.09 322890.0 -147000.0 -0.69 -1.2627 -0.9757 3092595 BCB03_000167 CCOC(=O)C1=CC[C@H](N([C@H]1c2ccc(SC)cc2)S(=O)(=O)c3ccc(C)cc3)c4ccc(OCc5ccccc5)c(OC)c4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 I11 compound treatment 465820.0 -17100.0 -0.09 462440.0 -7650.0 -0.04 -0.0857 -0.9264 BCB03_000168 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 I12 compound treatment 200960.0 -282000.0 -1.41 158940.0 -311000.0 -1.46 -2.0306 -0.9998 3000949 BCB03_000169 CCOC(=O)C1=CC[C@H](N([C@H]1c2ccc(cc2)[N+](=O)[O-])S(=O)(=O)c3ccc(C)cc3)c4cccc(Br)c4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 I13 compound treatment 10800.0 -472000.0 -2.36 11680.0 -458000.0 -2.16 -3.1919 -0.999 3107360 BCB03_000170 Cc1ccc(cc1)S(=O)(=O)O.Cc1cc(=O)oc2ccccc12 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 I14 compound treatment 612820.0 130000.0 0.65 523560.0 53500.0 0.25 0.6367 0.9149 3000951 BCB03_000171 CCOC(=O)C1=CCC(N(C1)S(=O)(=O)c2ccc(C)cc2)c3ccc(C)cc3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 I15 compound treatment 530840.0 47900.0 0.24 574030.0 104000.0 0.49 0.5151 0.9461 1952728 BCB03_000172 Cc1ccc2oc(=O)cc(c3cccs3)c2c1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 I16 compound treatment 357530.0 -125000.0 -0.63 181690.0 -288000.0 -1.36 -1.4019 -0.9383 3000952 BCB03_000173 CCOC(=O)C1=CCC(N(C1)S(=O)(=O)c2ccc(C)cc2)c3cccc4ccccc34 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 I17 compound treatment 521090.0 38200.0 0.19 235110.0 -235000.0 -1.11 -0.6466 -0.5765 1952730 BCB03_000174 O=c1cc(Cc2ccccc2)c3ccccc3o1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 I18 compound treatment 496590.0 13700.0 0.07 429440.0 -40600.0 -0.19 -0.0868 -0.4275 3092606 BCB03_000175 CCOC(=O)C1=CCC(N(C1)S(=O)(=O)c2ccc(C)cc2)c3ccc(F)cc3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 I19 compound treatment 114720.0 -368000.0 -1.84 106300.0 -364000.0 -1.71 -2.5102 -0.9994 1952746 BCB03_000176 Cc1ccc(cc1)c2cc(=O)oc3ccccc23 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 I20 compound treatment 399240.0 -83700.0 -0.42 420960.0 -49100.0 -0.23 -0.4588 -0.961 3092607 BCB03_000177 CCOC(=O)[C@@H]1N([C@@H](CC=C1C(=O)OCC)c2ccccc2)S(=O)(=O)c3ccc(C)cc3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 I21 mock treatment 526040.0 43100.0 0.22 437680.0 -32400.0 -0.15 0.0446 0.169 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 I22 mock treatment 347800.0 -135000.0 -0.67 501440.0 31400.0 0.15 -0.3728 -0.5398 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 I23 compound treatment 289410.0 -193000.0 -0.97 531810.0 61700.0 0.29 -0.478 -0.4737 3005760 BCB03_000178 CCOP(=O)(O)OCC.Cc1cc(=O)oc2ccc(Cl)cc12 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 I24 compound treatment 527490.0 44600.0 0.22 263890.0 -206000.0 -0.97 -0.5283 -0.5309 3000954 BCB03_000179 CCOC(=O)C1=CC[C@H](N([C@H]1c2ccc(C)cc2)S(=O)(=O)c3ccc(C)cc3)c4ccc(OC)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 J01 compound treatment 543460.0 60600.0 0.3 595960.0 126000.0 0.59 0.6326 0.9514 3092784 BCB03_000180 CCS[C@@H]1[C@@H](CC)N([C@H]([C@@H]1C(=O)O)c2ccc(C)cc2)S(=O)(=O)c3ccc(C)cc3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 J02 compound treatment 336400.0 -146000.0 -0.73 532660.0 62600.0 0.29 -0.3092 -0.3921 3187985 BCB03_000181 NC(=O)N1C(=O)C2C(C3C(N(Cc4cc5OCOc5cc4Br)C2C=C3CCCO)c6cccs6)C1=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 J03 compound treatment 548040.0 65100.0 0.33 596170.0 126000.0 0.59 0.6494 0.9601 3092785 BCB03_000182 CCOC1=C2C(N(CC2C3C(C1)C(=O)N(C3=O)c4ccccc4)S(=O)(=O)c5ccc(C)cc5)c6ccc(C)cc6 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 J04 compound treatment 475200.0 -7690.0 -0.04 495490.0 25400.0 0.12 0.0573 0.4568 3187986 BCB03_000183 CN1CCC(=CC1c2ccc(CN3CCCC3)cc2)CCCO 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 J05 mock treatment 228320.0 -255000.0 -1.27 532820.0 62700.0 0.3 -0.6904 -0.5289 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 J06 mock treatment 588160.0 105000.0 0.53 207680.0 -262000.0 -1.23 -0.501 -0.3734 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 J07 compound treatment 242010.0 -241000.0 -1.2 243160.0 -227000.0 -1.07 -1.6055 -0.9982 3001173 BCB03_000184 CCOC1=C2C(N(CC2n3n(C1)c(=O)n(c4ccccc4)c3=O)S(=O)(=O)c5ccc(C)cc5)c6ccc(C)cc6 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 J08 compound treatment 104800.0 -378000.0 -1.89 301470.0 -169000.0 -0.79 -1.8961 -0.9258 3070607 BCB03_000185 OCCCC1=CC(N(Cc2cccc(OC(F)(F)F)c2)CC1)c3ccc(CN4CCCC4)cc3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 J09 compound treatment 603750.0 121000.0 0.6 572020.0 102000.0 0.48 0.7659 0.9935 3001174 BCB03_000186 Cc1ccc(cc1)C2C3C(CN2S(=O)(=O)c4ccc(C)cc4)C5C(CC3=O)C(=O)N(C5=O)c6ccccc6 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 J10 compound treatment 188520.0 -294000.0 -1.47 495930.0 25800.0 0.12 -0.9537 -0.6464 3070608 BCB03_000187 OCCCC1=CC(N(Cc2cc3OCOc3cc2Br)CC1)c4cccs4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 J11 compound treatment 193560.0 -289000.0 -1.45 233210.0 -237000.0 -1.11 -1.8097 -0.9917 3092789 BCB03_000188 CCN1C(=O)C2CC(=O)C3C(N(CC3C2C1=O)S(=O)(=O)c4ccc(C)cc4)c5ccc(C)cc5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 J12 compound treatment 393220.0 -89700.0 -0.45 335770.0 -134000.0 -0.63 -0.7634 -0.9858 3070609 BCB03_000189 CN1CCC(=CC1C2CC2)c3ccc(CO)cc3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 J13 compound treatment 469030.0 -13900.0 -0.07 404000.0 -66100.0 -0.31 -0.2688 -0.8439 3092790 BCB03_000190 CC[C@@H]1[C@@H]2[C@H]([C@@H](N1S(=O)(=O)c3ccc(C)cc3)c4ccc(C)cc4)C(=O)CC5C2C(=O)N(CC)C5=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 J14 compound treatment 262530.0 -220000.0 -1.1 254270.0 -216000.0 -1.02 -1.496 -0.9992 3187991 BCB03_000191 NC(=O)N1C(=O)C2C(C3C(C4CC4)N(Cc5cc6OCOc6cc5Br)C2C=C3CCCO)C1=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 J15 compound treatment 303720.0 -179000.0 -0.89 384420.0 -85700.0 -0.4 -0.9177 -0.9351 3092866 BCB03_000192 CC[C@@H]1[C@H]2[C@@H]([C@@H](N1S(=O)(=O)c3ccc(C)cc3)c4ccc(C)cc4)C(=O)CC5C2C(=O)N(CC)C5=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 J16 compound treatment 399360.0 -83500.0 -0.42 480770.0 10700.0 0.05 -0.2595 -0.6175 3187992 BCB03_000193 NC(=O)N1C(=O)C2C(C3C(C4CC4)N(Cc5cccc(OC(F)(F)F)c5)C2C=C3CCCO)C1=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 J17 compound treatment 599490.0 117000.0 0.58 476570.0 6480.0 0.03 0.4334 0.7431 3092867 BCB03_000194 CCOC(=O)C1=CC[C@H](N([C@H]1CC)S(=O)(=O)c2ccc(C)cc2)c3ccc(OC)cc3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 J18 compound treatment 482130.0 -761.0 0.0 518420.0 48300.0 0.23 0.1581 0.6952 3187993 BCB03_000195 CN1C(C2CC2)C3C4C(C1C=C3CCCO)C(=O)N(C(=O)N)C4=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 J19 compound treatment 428640.0 -54300.0 -0.27 485950.0 15900.0 0.07 -0.1388 -0.494 3092868 BCB03_000196 CCOC(=O)C1=CC[C@H](N(C1)S(=O)(=O)c2ccc(C)cc2)c3ccccc3Cl 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 J20 compound treatment 234580.0 -248000.0 -1.24 209810.0 -260000.0 -1.22 -1.7426 -1.0 3187994 BCB03_000197 CS(=O)(=O)CCOC(=O)C1=CN(Cc2cccc(OC(F)(F)F)c2)C(C=C(CCCO)C=C1C(=O)OCCS(=O)(=O)C)C3CC3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 J21 mock treatment 531090.0 48200.0 0.24 311090.0 -159000.0 -0.75 -0.3586 -0.4564 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 J22 mock treatment 508740.0 25800.0 0.13 510500.0 40400.0 0.19 0.2257 0.9822 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 J23 compound treatment 337880.0 -145000.0 -0.72 459570.0 -10500.0 -0.05 -0.5471 -0.7536 3092869 BCB03_000198 CCOC(=O)C1=CC[C@H](N(C1)S(=O)(=O)c2ccc(C)cc2)c3cccc(Cl)c3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 J24 compound treatment 412370.0 -70500.0 -0.35 216810.0 -253000.0 -1.19 -1.0914 -0.8786 3070656 BCB03_000199 CN1C=C(C(=O)OCCS(=O)(=O)C)C(=CC(=CC1c2cccs2)CCCO)C(=O)OCCS(=O)(=O)C 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 K01 compound treatment 317760.0 -165000.0 -0.82 608660.0 139000.0 0.65 -0.1223 -0.1163 3005761 BCB03_000200 Cc1ccc(cc1)S(=O)(=O)O.Cc1cc(=O)oc2ccc(Cl)cc12 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 K02 compound treatment 660820.0 178000.0 0.89 633170.0 163000.0 0.77 1.1708 0.9973 3000955 BCB03_000201 CCOC(=O)C1=CC[C@H](N([C@H]1C)S(=O)(=O)c2ccc(C)cc2)c3ccccc3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 K03 compound treatment 584320.0 101000.0 0.51 646450.0 176000.0 0.83 0.9448 0.972 1952748 BCB03_000202 O=Cc1cccc(c1)c2cc(=O)oc3ccccc23 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 K04 compound treatment 542400.0 59500.0 0.3 515780.0 45700.0 0.21 0.3621 0.9873 3092688 BCB03_000203 CCOC(=O)C1=CCC(N(C1)S(=O)(=O)c2ccc(C)cc2)c3ccncc3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 K05 compound treatment 17300.0 -466000.0 -2.33 23480.0 -447000.0 -2.1 -3.1297 -0.9987 1107217 BCB03_000204 Cc1cccnc1I 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 K06 compound treatment 196120.0 -287000.0 -1.43 560590.0 90500.0 0.43 -0.7118 -0.4763 3000965 BCB03_000205 CCOC(=O)C1=CC[C@H](N([C@H]1C=C(C)C)S(=O)(=O)c2ccc(C)cc2)c3ccccc3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 K07 mock treatment 664370.0 181000.0 0.91 568990.0 98900.0 0.47 0.9699 0.952 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 K08 mock treatment 440520.0 -42400.0 -0.21 635060.0 165000.0 0.78 0.3991 0.4961 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 K09 compound treatment 685080.0 202000.0 1.01 645890.0 176000.0 0.83 1.2988 0.9951 3005761 BCB03_000206 Cc1ccc(cc1)S(=O)(=O)O.Cc1cc(=O)oc2ccc(Cl)cc12 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 K10 compound treatment 302950.0 -180000.0 -0.9 183260.0 -287000.0 -1.35 -1.5895 -0.9805 3000966 BCB03_000207 CCOC(=O)C1=CC[C@H](N([C@H]1C#N)S(=O)(=O)c2ccc(C)cc2)c3ccccc3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 K11 compound treatment 179690.0 -303000.0 -1.51 355320.0 -115000.0 -0.54 -1.4525 -0.9035 1952755 BCB03_000208 C=C(c1ccccc1)c2cc(=O)oc3ccccc23 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 K12 compound treatment 216980.0 -266000.0 -1.33 438520.0 -31600.0 -0.15 -1.0441 -0.7813 3092692 BCB03_000209 CCOC(=O)C1=CC[C@H](N([C@H]1c2cccc(OC)c2)S(=O)(=O)c3ccc(C)cc3)c4ccccc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 K13 compound treatment 410720.0 -72200.0 -0.36 300920.0 -169000.0 -0.8 -0.8175 -0.9359 1952760 BCB03_000210 CC(C)(C)[Si](C)(C)OCCNC(=O)c1cc(c2cc(F)cc(F)c2)c3oc4c(C(=O)OC4(c5ccccc5)c6ccccc6)c3c1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 K14 compound treatment 297170.0 -186000.0 -0.93 472100.0 2010.0 0.01 -0.6492 -0.6999 3092693 BCB03_000211 CCOC(=O)C1=CC[C@H](N([C@H]1c2ccc(C#N)cc2)S(=O)(=O)c3ccc(C)cc3)c4ccccc4C(F)(F)F 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 K15 mock treatment 587480.0 105000.0 0.52 312820.0 -157000.0 -0.74 -0.1537 -0.1697 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 K16 mock treatment 459200.0 -23700.0 -0.12 568860.0 98800.0 0.46 0.2449 0.5107 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 K17 compound treatment 589130.0 106000.0 0.53 585190.0 115000.0 0.54 0.758 0.9999 1952770 BCB03_000212 O=C/1Oc2ccccc2C\C1=C(/c3ccccc3)\c4ccc5ccccc5c4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 K18 compound treatment 552550.0 69700.0 0.35 604210.0 134000.0 0.63 0.6921 0.9607 3000969 BCB03_000213 CCOC(=O)C1=CC[C@H](N([C@H]1C=C)S(=O)(=O)c2ccc(C)cc2)c3ccccc3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 K19 compound treatment 585440.0 103000.0 0.51 482760.0 12700.0 0.06 0.4043 0.7841 3000871 BCB03_000214 O=c1cccc(o1)c2ccccc2 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 K20 compound treatment 218880.0 -264000.0 -1.32 243240.0 -227000.0 -1.07 -1.6869 -0.9945 3001047 BCB03_000215 CCOC(=O)C1=CC[C@H](N([C@H]1c2ccccc2)S(=O)(=O)c3ccc(C)cc3)c4ccc(c(OC)c4)c5ccc(OCc6ccccc6)cc5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 K21 compound treatment 576510.0 93600.0 0.47 418570.0 -51500.0 -0.24 0.1593 0.3025 3000872 BCB03_000216 COc1cccc(c1)c2cccc(=O)o2 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 K22 compound treatment 484240.0 1350.0 0.01 227080.0 -243000.0 -1.14 -0.8035 -0.7029 3001048 BCB03_000217 CCOC(=O)C1=CC[C@H](N([C@H]1c2ccccc2)S(=O)(=O)c3ccc(C)cc3)c4ccc(cc4)[N+](=O)[O-] 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 K23 mock treatment 568690.0 85800.0 0.43 457790.0 -12300.0 -0.06 0.2621 0.6062 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 K24 mock treatment 456390.0 -26500.0 -0.13 284930.0 -185000.0 -0.87 -0.7094 -0.8053 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 L01 compound treatment 598490.0 116000.0 0.58 518120.0 48000.0 0.23 0.568 0.9162 3092870 BCB03_000218 CCOC(=O)C1=CC[C@H](N(C1)S(=O)(=O)c2ccc(C)cc2)c3ccccc3C(F)(F)F 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 L02 compound treatment 493850.0 11000.0 0.05 487590.0 17500.0 0.08 0.0969 0.9803 3188115 BCB03_000219 CS(=O)(=O)CCOC(=O)C1=CN(Cc2cc3OCOc3cc2Br)C(C=C(CCCO)C=C1C(=O)OCCS(=O)(=O)C)c4cccs4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 L03 compound treatment 524170.0 41300.0 0.21 556240.0 86200.0 0.41 0.4323 0.9509 3092871 BCB03_000220 CCOC(=O)C1=CC[C@H](N([C@H]1c2cccc(Br)c2)S(=O)(=O)c3ccc(C)cc3)c4ccc(OCC=C)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 L04 compound treatment 204910.0 -278000.0 -1.39 529850.0 59800.0 0.28 -0.783 -0.5527 3188116 BCB03_000221 CC1C=C(CCCO)C=C(C(=O)OCCS(=O)(=O)C)C(=CN1Cc2cccc(OC(F)(F)F)c2)C(=O)OCCS(=O)(=O)C 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 L05 compound treatment 569660.0 86800.0 0.43 572540.0 102000.0 0.48 0.6472 0.9986 3092774 BCB03_000222 CC[C@@H]1C(Sc2ccccc2)C([C@@H](N1S(=O)(=O)c3ccc(C)cc3)c4ccc(C)cc4)C(=O)O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 L06 compound treatment 483840.0 949.0 0.0 262340.0 -208000.0 -0.98 -0.6876 -0.7037 3188117 BCB03_000223 CS(=O)(=O)CCOC(=O)C1=CN(Cc2sc3ccccc3c2Cl)C(C=C(CCCO)C=C1C(=O)OCCS(=O)(=O)C)C4CC4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 L07 mock treatment 567370.0 84500.0 0.42 572250.0 102000.0 0.48 0.6381 0.9979 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 L08 mock treatment 541440.0 58500.0 0.29 217520.0 -253000.0 -1.19 -0.6333 -0.5176 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 L09 compound treatment 408410.0 -74500.0 -0.37 320920.0 -149000.0 -0.7 -0.7592 -0.956 3187870 BCB03_000224 COC(=O)C[C@H]1O[C@@H](CCc2ccccc2)[C@@H](C)[C@@H]1[Si](C)(C)c3ccc(OC)cc3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 L10 compound treatment 319130.0 -164000.0 -0.82 468330.0 -1760.0 -0.01 -0.5842 -0.7142 3188119 BCB03_000225 CS(=O)(=O)CCOC(=O)C1=CN(Cc2sc3ccccc3c2Cl)C(C=C(CCCO)C=C1C(=O)OCCS(=O)(=O)C)c4ccc(CN5CCCC5)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 L11 compound treatment 441240.0 -41700.0 -0.21 486820.0 16700.0 0.08 -0.0914 -0.4111 3071511 BCB03_000226 COC(=O)C[C@H]1O[C@@]2([C@@H](C)[C@@H]1[Si](C)(C)c3ccc(OC)cc3)C(=O)N(Cc4ccccc4)c5ccc(I)cc52 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 L12 compound treatment 405490.0 -77400.0 -0.39 309440.0 -161000.0 -0.76 -0.8077 -0.9516 3188120 BCB03_000227 CS(=O)(=O)CCOC(=O)C1=CN(Cc2cccc(OC(F)(F)F)c2)C(C=C(CCCO)C=C1C(=O)OCCS(=O)(=O)C)c3cccs3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 L13 compound treatment 378240.0 -105000.0 -0.52 472130.0 2040.0 0.01 -0.3628 -0.694 3187872 BCB03_000228 COC(=O)C[C@H]1O[C@@]2([C@@H](C)[C@@H]1[Si](C)(C)c3ccc(OC)cc3)C(=O)N(Cc4ccccc4)c5ccc(NC(=O)C)cc52 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 L14 compound treatment 274970.0 -208000.0 -1.04 366890.0 -103000.0 -0.49 -1.0775 -0.94 3188122 BCB03_000229 CS(=O)(=O)CCOC(=O)C1=CN(Cc2cccc(OC(F)(F)F)c2)C(C=C(C=C1C(=O)OCCS(=O)(=O)C)c3ccc(CO)cc3)c4cccs4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 L15 mock treatment 398950.0 -83900.0 -0.42 535330.0 65200.0 0.31 -0.0795 -0.1529 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 L16 mock treatment 428070.0 -54800.0 -0.27 563250.0 93200.0 0.44 0.1163 0.225 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 L17 compound treatment 566080.0 83200.0 0.42 557500.0 87400.0 0.41 0.5845 1.0 3414061 BCB03_000230 COC(=O)C[C@@H]1C[C@H](C)[C@]2(O1)C(=O)N(Cc3ccccc3)c4ccc(NC(=O)C)cc42 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 L18 compound treatment 309140.0 -174000.0 -0.87 336480.0 -134000.0 -0.63 -1.058 -0.9874 3188123 BCB03_000231 CN1C=C(C(=O)OCCS(=O)(=O)C)C(=CC(=CC1c2cccs2)c3ccc(CO)cc3)C(=O)OCCS(=O)(=O)C 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 L19 compound treatment 493280.0 10400.0 0.05 518180.0 48100.0 0.23 0.1966 0.8473 3071513 BCB03_000232 CC(C)[Si](OCC[C@H]1O[C@@]2([C@@H](C)[C@@H]1[Si](C)(C)O)C(=O)N(Cc3ccccc3)c4ccccc42)(C(C)C)C(C)C 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 L20 compound treatment 125330.0 -358000.0 -1.79 148320.0 -322000.0 -1.51 -2.333 -0.9966 3188124 BCB03_000233 CS(=O)(=O)CCOC(=O)C1=CN(Cc2sc3ccccc3c2Cl)C(C=C(C=C1C(=O)OCCS(=O)(=O)C)c4ccc(CO)cc4)C5CC5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 L21 compound treatment 243040.0 -240000.0 -1.2 476860.0 6770.0 0.03 -0.8245 -0.6881 3071514 BCB03_000234 COc1ccc(cc1)[Si](C)(C)[C@H]2[C@H](C)[C@]3(O[C@@H]2CCO)C(=O)N(Cc4ccccc4)c5ccccc53 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 L22 compound treatment 270240.0 -213000.0 -1.06 222320.0 -248000.0 -1.17 -1.5751 -0.9989 3188125 BCB03_000235 CS(=O)(=O)CCOC(=O)C1=CN(Cc2cc3OCOc3cc2Br)C(C=C(CCCO)C=C1C(=O)OCCS(=O)(=O)C)c4ccc(CN5CCCC5)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 L23 mock treatment 539740.0 56800.0 0.28 534910.0 64800.0 0.3 0.4164 0.9994 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 L24 mock treatment 317830.0 -165000.0 -0.82 559440.0 89400.0 0.42 -0.2858 -0.3088 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 M01 compound treatment 577960.0 95100.0 0.47 622610.0 153000.0 0.72 0.843 0.9799 1984103 BCB03_000236 Cc1ccc(cc1)c2cccc(=O)o2 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 M02 compound treatment 596340.0 113000.0 0.57 609830.0 140000.0 0.66 0.8654 0.9973 3001049 BCB03_000237 CCOC(=O)C1=CCC(N(C1)S(=O)(=O)c2ccc(C)cc2)c3ccc(cc3)[N+](=O)[O-] 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 M03 compound treatment 627330.0 144000.0 0.72 568110.0 98000.0 0.46 0.8361 0.9766 3000873 BCB03_000238 Clc1cccc(c1)c2cccc(=O)o2 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 M04 compound treatment 564760.0 81900.0 0.41 618500.0 148000.0 0.7 0.7828 0.9675 3092778 BCB03_000239 CCOC(=O)C1=CC[C@H](N([C@H]1c2ccc(CC)cc2)S(=O)(=O)c3ccc(C)cc3)c4ccccc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 M05 compound treatment 460810.0 -22100.0 -0.11 600600.0 131000.0 0.61 0.3561 0.5709 3000875 BCB03_000240 Clc1ccccc1c2cccc(=O)o2 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 M06 compound treatment 252320.0 -231000.0 -1.15 561130.0 91000.0 0.43 -0.5115 -0.4163 3001168 BCB03_000241 CCOC(=O)C1=C(N([C@@H](CC1)c2ccccc2)S(=O)(=O)CC[Si](C)(C)C)C(=O)OCC 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 M07 compound treatment 569650.0 86800.0 0.43 581310.0 111000.0 0.52 0.6763 0.9956 3000956 BCB03_000242 CCCc1cccc(=O)o1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 M08 compound treatment 537050.0 54200.0 0.27 430670.0 -39400.0 -0.19 0.0602 0.1835 3092780 BCB03_000243 CCOC(=O)C1=CC[C@H](N([C@H]1c2ccc(OC)cc2)S(=O)(=O)c3ccc(C)cc3)c4cc(Cl)ccc4Cl 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 M09 mock treatment 475520.0 -7370.0 -0.04 585160.0 115000.0 0.54 0.3567 0.6575 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 M10 mock treatment 542840.0 59900.0 0.3 584530.0 114000.0 0.54 0.5924 0.9617 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 M11 compound treatment 520510.0 37600.0 0.19 569120.0 99000.0 0.47 0.4622 0.9203 3000957 BCB03_000244 Fc1ccc(cc1)c2cccc(=O)o2 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 M12 compound treatment 573440.0 90500.0 0.45 599520.0 129000.0 0.61 0.7503 0.9893 3092781 BCB03_000245 CCOC(=O)C1=CCC(N(C1)S(=O)(=O)c2ccc(cc2)[N+](=O)[O-])c3ccccc3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 M13 mock treatment 499070.0 16200.0 0.08 430360.0 -39700.0 -0.19 -0.075 -0.3684 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 M14 mock treatment 500120.0 17200.0 0.09 457440.0 -12600.0 -0.06 0.0188 0.1796 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 M15 compound treatment 502480.0 19600.0 0.1 517160.0 47100.0 0.22 0.2257 0.9326 3000958 BCB03_000246 O=c1cccc(o1)c2ccc(C#N)cc2 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 M16 compound treatment 154090.0 -329000.0 -1.64 116840.0 -353000.0 -1.66 -2.3361 -1.0 3001177 BCB03_000247 CCOC(=O)C1=CCC(N(C1)S(=O)(=O)c2ccc(C)cc2)c3ccco3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 M17 compound treatment 557600.0 74700.0 0.37 374910.0 -95200.0 -0.45 -0.0527 -0.0904 3092682 BCB03_000248 FC(F)(F)c1ccc(cc1)c2cccc(=O)o2 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 M18 compound treatment 212610.0 -270000.0 -1.35 372270.0 -97800.0 -0.46 -1.2799 -0.8974 3001178 BCB03_000249 CCOC(=O)C1=CC[C@H](N([C@@H]1C#N)S(=O)(=O)c2ccc(C)cc2)c3ccccc3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 M19 compound treatment 261920.0 -221000.0 -1.1 395220.0 -74900.0 -0.35 -1.0294 -0.8886 3000960 BCB03_000250 FC(F)(F)c1ccccc1c2cccc(=O)o2 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 M20 compound treatment 477130.0 -5760.0 -0.03 554150.0 84100.0 0.4 0.2592 0.6539 3001179 BCB03_000251 CCOC(=O)C1=CCC(N(C1)S(=O)(=O)CC[Si](C)(C)C)c2ccccc2 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 M21 compound treatment 476960.0 -5930.0 -0.03 382930.0 -87200.0 -0.41 -0.3108 -0.7562 3000961 BCB03_000252 O=c1cccc(o1)c2ccc3ccccc3c2 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 M22 compound treatment 129950.0 -353000.0 -1.76 126260.0 -344000.0 -1.62 -2.39 -0.9991 3001245 BCB03_000253 CCOC(=O)C1=CCC(N(C1)S(=O)(=O)c2ccc(C)cc2)c3cccn3C(=O)OC(C)(C)C 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 M23 compound treatment 407690.0 -75200.0 -0.38 316580.0 -154000.0 -0.72 -0.7761 -0.9536 3092685 BCB03_000254 O=c1cccc(o1)c2ccco2 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 M24 compound treatment 257640.0 -225000.0 -1.13 235450.0 -235000.0 -1.1 -1.5759 -1.0 3001246 BCB03_000255 CCOC(=O)C1=CCC(N(C1)S(=O)(=O)c2ccc(C)cc2)c3ccc(C#N)cc3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 N01 compound treatment 389980.0 -92900.0 -0.46 507060.0 37000.0 0.17 -0.2052 -0.414 3071515 BCB03_000256 COC(=O)C[C@H]1O[C@@]2([C@@H](C)[C@@H]1[Si](C)(C)c3ccc(C)cc3)C(=O)N(C)c4ccccc42 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 N02 compound treatment 604490.0 122000.0 0.61 530810.0 60700.0 0.29 0.6314 0.9408 3188247 BCB03_000257 CN1C=C(C(=O)OCCS(=O)(=O)C)C(=CC(=CC1C2CC2)CCCO)C(=O)OCCS(=O)(=O)C 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 N03 compound treatment 255000.0 -228000.0 -1.14 562580.0 92500.0 0.44 -0.4972 -0.408 3071516 BCB03_000258 COC(=O)C[C@H]1O[C@@]2([C@@H](C)[C@@H]1[Si](C)(C)c3ccc(OC)cc3)C(=O)N(C)c4ccccc42 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 N04 compound treatment 487610.0 4720.0 0.02 495010.0 24900.0 0.12 0.0996 0.8326 3188248 BCB03_000259 CS(=O)(=O)CCOC(=O)C1=CN(Cc2cc3OCOc3cc2Br)C(C=C(CCCO)C=C1C(=O)OCCS(=O)(=O)C)C4CC4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 N05 compound treatment 488500.0 5610.0 0.03 480760.0 10700.0 0.05 0.0553 0.962 3414062 BCB03_000260 COC(=O)C[C@H]1O[C@@]2([C@@H](C)[C@@H]1[Si](C)(C)c3ccccc3)C(=O)N(C)c4ccccc42 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 N06 compound treatment 172080.0 -311000.0 -1.55 298190.0 -172000.0 -0.81 -1.6694 -0.9538 3188250 BCB03_000261 CS(=O)(=O)CCOC(=O)C1=CN(Cc2cc3OCOc3cc2Br)C(C=C(C=C1C(=O)OCCS(=O)(=O)C)c4ccc(CO)cc4)C5CC5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 N07 compound treatment 251360.0 -232000.0 -1.16 513520.0 43400.0 0.2 -0.6732 -0.5733 3188927 BCB03_000262 COC(=O)C[C@H]1O[C@@]2([C@@H](C)[C@@H]1[Si](C)(C)F)C(=O)N(C)c3ccccc32 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 N08 compound treatment 209440.0 -273000.0 -1.37 246750.0 -223000.0 -1.05 -1.7085 -0.9916 3188251 BCB03_000263 CS(=O)(=O)CCOC(=O)C1=CN(Cc2cccc(OC(F)(F)F)c2)C(C=C(CCCO)C=C1C(=O)OCCS(=O)(=O)C)c3ccc(CN4CCCC4)cc3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 N09 mock treatment 549450.0 66600.0 0.33 273930.0 -196000.0 -0.92 -0.4174 -0.4256 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 N10 mock treatment 343270.0 -140000.0 -0.7 487120.0 17000.0 0.08 -0.4364 -0.6218 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 N11 compound treatment 442510.0 -40400.0 -0.2 325130.0 -145000.0 -0.68 -0.6247 -0.8786 3071435 BCB03_000264 COC(=O)C[C@H]1O[C@@]2(C[C@@H]1[Si](C)(C)C)C(=O)N(C)c3ccccc32 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 N12 compound treatment 309600.0 -173000.0 -0.87 314630.0 -155000.0 -0.73 -1.129 -0.9965 3188252 BCB03_000265 CN1C=C(C(=O)OCCS(=O)(=O)C)C(=CC(=CC1C2CC2)c3ccc(CO)cc3)C(=O)OCCS(=O)(=O)C 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 N13 mock treatment 342460.0 -140000.0 -0.7 506810.0 36700.0 0.17 -0.3738 -0.5175 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 N14 mock treatment 513820.0 30900.0 0.15 484160.0 14100.0 0.07 0.156 0.9285 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 N15 compound treatment 432800.0 -50100.0 -0.25 560840.0 90800.0 0.43 0.1249 0.2525 3188929 BCB03_000266 COC(=O)C/C=C/C[C@]1(O)C(=O)N(C)c2ccccc21 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 N16 compound treatment 429220.0 -53700.0 -0.27 420200.0 -49900.0 -0.23 -0.3555 -0.9978 3188253 BCB03_000267 COP(=O)(OC)/N=C\1/CC(=CC(N1C)c2cccs2)c3ccc(CO)cc3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 N17 compound treatment 241180.0 -242000.0 -1.21 533570.0 63500.0 0.3 -0.6425 -0.5166 3188930 BCB03_000268 COc1ccc(cc1)[Si](C)(C)[C@H](CCn2cc(CCO[Si](C(C)C)(C(C)C)C(C)C)nn2)/C=C/C 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 N18 compound treatment 310520.0 -172000.0 -0.86 278200.0 -192000.0 -0.9 -1.247 -0.9997 3188254 BCB03_000269 CN1C=C(C(=O)OCCS(=O)(=O)C)C(=CC(=CC1c2ccc(CN3CCCC3)cc2)CCCO)C(=O)OCCS(=O)(=O)C 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 N19 compound treatment 535000.0 52100.0 0.26 313220.0 -157000.0 -0.74 -0.3377 -0.4316 3071465 BCB03_000270 CCCCNC(=O)c1ccc(C#CC(C)(C)C)c(OC(=O)C)c1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 N20 compound treatment 189920.0 -293000.0 -1.46 151960.0 -318000.0 -1.5 -2.0928 -0.9999 3188255 BCB03_000271 COP(=O)(OC)/N=C\1/CC(=CC(C2CC2)N1Cc3sc4ccccc4c3Cl)CCCO 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 N21 compound treatment 400480.0 -82400.0 -0.41 354590.0 -115000.0 -0.54 -0.6752 -0.9906 1952196 BCB03_000272 CCCCNC(=O)c1ccc(C#C[Si](C)(C)C)c(OC(=O)C)c1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 N22 compound treatment 185120.0 -298000.0 -1.49 318010.0 -152000.0 -0.72 -1.5574 -0.9437 3188256 BCB03_000273 COP(=O)(OC)/N=C\1/CC(=CC(N1Cc2sc3ccccc3c2Cl)c4ccc(CN5CCCC5)cc4)CCCO 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 N23 compound treatment 239640.0 -243000.0 -1.21 489070.0 19000.0 0.09 -0.7959 -0.6534 3071510 BCB03_000274 CCCCNC(=O)c1ccc(C#C[Si](C(C)C)(C(C)C)C(C)C)c(OC(=O)C)c1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 N24 compound treatment 451890.0 -31000.0 -0.15 392880.0 -77200.0 -0.36 -0.3663 -0.9278 3188257 BCB03_000275 COP(=O)(OC)/N=C\1/CC(=CC(N1C)c2cccs2)CCCO 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 O01 compound treatment 206560.0 -276000.0 -1.38 361630.0 -108000.0 -0.51 -1.3366 -0.9084 3000963 BCB03_000276 O=c1cccc(CCc2ccccc2)o1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 O02 compound treatment 478360.0 -4530.0 -0.02 462240.0 -7850.0 -0.04 -0.0421 -0.9724 3001247 BCB03_000277 CCOC(=O)C1=CCC(NC1)c2cc3ccccc3[nH]2 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 O03 compound treatment 551460.0 68600.0 0.34 568390.0 98300.0 0.46 0.5691 0.9891 3000971 BCB03_000278 [O-][N+](=O)c1ccc(cc1)c2cccc(=O)o2 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 O04 compound treatment 528640.0 45700.0 0.23 524810.0 54700.0 0.26 0.3436 0.9982 3001248 BCB03_000279 CCOC(=O)C1=CCC(N(C1)S(=O)(=O)c2ccccc2[N+](=O)[O-])c3cc4ccccc4[nH]3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 O05 compound treatment 590890.0 108000.0 0.54 576100.0 106000.0 0.5 0.734 0.9992 3000972 BCB03_000280 O=c1cccc(/C=C/c2ccccc2)o1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 O06 compound treatment 521400.0 38500.0 0.19 499290.0 29200.0 0.14 0.2331 0.9864 3000756 BCB03_000281 CCOC(=O)C1=CCC(N(CCN2CC(=CCC2c3cc4ccccc4[nH]3)C(=O)OCC)C1)c5cc6ccccc6[nH]5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 O07 compound treatment 448680.0 -34200.0 -0.17 349000.0 -121000.0 -0.57 -0.5236 -0.8805 3000973 BCB03_000282 O=c1cccc(o1)c2cccc3ccccc23 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 O08 compound treatment 195580.0 -287000.0 -1.43 262210.0 -208000.0 -0.98 -1.7061 -0.9825 3000757 BCB03_000283 CC(=O)C1=CCC(N(C1)S(=O)(=O)c2ccc(C)cc2)c3ccccc3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 O09 compound treatment 430820.0 -52100.0 -0.26 478170.0 8080.0 0.04 -0.157 -0.5974 3000974 BCB03_000284 CC(C)OC(=O)/C=C/1\C[C@H](O[C@H](O1)c2cccc(Cl)c2)c3cccc(Cl)c3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 O10 compound treatment 429690.0 -53200.0 -0.27 378090.0 -92000.0 -0.43 -0.4939 -0.9726 3093828 BCB03_000285 Cc1ccc(cc1)[C@@H]2C[C@@H](Sc3ccccc3)[C@@H](CN2S(=O)(=O)c4ccc(C)cc4)C(=O)O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 O11 mock treatment 356250.0 -127000.0 -0.63 554160.0 84100.0 0.4 -0.1676 -0.2247 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 O12 mock treatment 551570.0 68700.0 0.34 529950.0 59900.0 0.28 0.4417 0.9952 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 O13 compound treatment 346460.0 -136000.0 -0.68 469960.0 -127.0 0.0 -0.4822 -0.7077 3092701 BCB03_000286 CCOC(=O)/C=C/1\C[C@H](O[C@H](O1)c2cccc(c2)[N+](=O)[O-])c3cccc(c3)[N+](=O)[O-] 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 O14 compound treatment 513940.0 31000.0 0.16 501220.0 31100.0 0.15 0.2132 0.9996 3093829 BCB03_000287 Cc1ccc(cc1)C2CC=C(CN2S(=O)(=O)c3ccc(C)cc3)C(=O)O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 O15 compound treatment 287540.0 -195000.0 -0.98 467260.0 -2830.0 -0.01 -0.6993 -0.7167 3092771 BCB03_000288 CC(C)OC(=O)/C=C/1\C[C@H](O[C@H](O1)c2ccccn2)c3ccccn3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 O16 compound treatment 361570.0 -121000.0 -0.61 461920.0 -8170.0 -0.04 -0.4556 -0.7504 3093830 BCB03_000289 Cc1ccc(cc1)S(=O)(=O)N2CC(=CCC2c3ccccc3)C(=O)O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 O17 compound treatment 377640.0 -105000.0 -0.53 265630.0 -204000.0 -0.96 -1.0517 -0.9596 3092772 BCB03_000290 COC(=O)c1cccc(c1)[C@@H]2C/C(=C\C(=O)OC(C)C)/O[C@@H](O2)c3cccc(c3)C(=O)OC 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 O18 compound treatment 389920.0 -93000.0 -0.46 421120.0 -49000.0 -0.23 -0.4912 -0.9477 3000760 BCB03_000291 Cc1ccc(cc1)[C@@H]2CC=C([C@@H](N2S(=O)(=O)c3ccc(C)cc3)c4ccccc4)C(=O)O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 O19 compound treatment 282100.0 -201000.0 -1.0 401920.0 -68200.0 -0.32 -0.9358 -0.8889 3000977 BCB03_000292 CC(C)OC(=O)/C=C\1/C[C@H](O[C@H](O1)c2ccc(C#N)cc2)c3ccc(C#N)cc3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 O20 compound treatment 342780.0 -140000.0 -0.7 257760.0 -212000.0 -1.0 -1.201 -0.9849 3093833 BCB03_000293 Cc1ccc(cc1)S(=O)(=O)N2[C@@H](CC=C([C@@H]2c3ccccc3)C(=O)O)c4ccccc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 O21 compound treatment 323010.0 -160000.0 -0.8 479140.0 9050.0 0.04 -0.5345 -0.6685 3092782 BCB03_000294 CC(C)OC(=O)/C=C/1\C[C@H](O[C@H](O1)c2ccc(cc2)C(F)(F)F)c3ccc(cc3)C(F)(F)F 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 O22 compound treatment 300170.0 -183000.0 -0.91 527200.0 57100.0 0.27 -0.4553 -0.4787 3093834 BCB03_000295 Cc1ccc(cc1)S(=O)(=O)N2[C@@H](CC=C([C@@H]2c3ccccc3)C(=O)O)c4ccc(C#N)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 O23 compound treatment 221170.0 -262000.0 -1.31 243040.0 -227000.0 -1.07 -1.6795 -0.995 3092786 BCB03_000296 CC(C)OC(=O)/C=C/1\C[C@H](O[C@H](O1)c2cccc(c2)C(F)(F)F)c3cccc(c3)C(F)(F)F 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 O24 compound treatment 380880.0 -102000.0 -0.51 436170.0 -33900.0 -0.16 -0.4731 -0.8861 3093844 BCB03_000297 Cc1ccc(cc1)S(=O)(=O)N2[C@@H](CC=C([C@@H]2c3ccccc3)C(=O)O)c4ccc(F)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 P01 compound treatment 485140.0 2250.0 0.01 491570.0 21500.0 0.1 0.0794 0.7809 3071725 BCB03_000298 COC(=O)[C@H](Cc1ccc(O)cc1)N[C@@H](/C=C/C2CC2)[C@H](O)Cc3ccccc3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 P02 compound treatment 428240.0 -54700.0 -0.27 480320.0 10200.0 0.05 -0.159 -0.5736 3188381 BCB03_000299 COP(=O)(OC)/N=C\1/CC(=CC(C2CC2)N1C)c3ccc(CO)cc3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 P03 compound treatment 196230.0 -287000.0 -1.43 198610.0 -271000.0 -1.28 -1.9153 -0.9984 3188399 BCB03_000300 COC(=O)[C@H](Cc1ccc(O)cc1)N(CC#C)[C@@H](/C=C/C2CC2)[C@H](O)Cc3ccccc3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 P04 compound treatment 245700.0 -237000.0 -1.18 396000.0 -74100.0 -0.35 -1.0841 -0.8779 3070118 BCB03_000301 COP(=O)(OC)/N=C\1/CC(=CC(C2CC2)N1Cc3cc4OCOc4cc3Br)CCCO 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 P05 compound treatment 194850.0 -288000.0 -1.44 184270.0 -286000.0 -1.34 -1.9679 -0.9994 3188400 BCB03_000302 COC(=O)[C@H](Cc1ccc(OCC#C)cc1)N(CC#C)[C@@H](/C=C/C2CC2)[C@H](O)Cc3ccccc3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 P06 compound treatment 167680.0 -315000.0 -1.57 237820.0 -232000.0 -1.09 -1.8857 -0.9841 3070119 BCB03_000303 COP(=O)(OC)/N=C\1/CC(=CC(C2CC2)N1Cc3cccc(OC(F)(F)F)c3)CCCO 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 P07 compound treatment 178530.0 -304000.0 -1.52 209120.0 -261000.0 -1.23 -1.9429 -0.9944 3188401 BCB03_000304 Oc1ccc(C[C@@H]2N(CC#C)[C@@H](/C=C/C3CC3)[C@@H](Cc4ccccc4)OC2=O)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 P08 compound treatment 251600.0 -231000.0 -1.16 225280.0 -245000.0 -1.15 -1.6311 -1.0 3188385 BCB03_000305 COP(=O)(OC)/N=C\1/CC(=CC(N1Cc2cccc(OC(F)(F)F)c2)c3ccc(CN4CCCC4)cc3)CCCO 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 P09 compound treatment 212370.0 -271000.0 -1.35 193340.0 -277000.0 -1.3 -1.8758 -0.9998 3188402 BCB03_000306 O=C1O[C@H](Cc2ccccc2)[C@H](/C=C/C3CC3)N(CC#C)[C@H]1Cc4ccc(OCC#C)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 P10 compound treatment 148270.0 -335000.0 -1.67 186890.0 -283000.0 -1.33 -2.1237 -0.9937 3188386 BCB03_000307 NC(=O)N1C(=O)C2C(C3C(N(Cc4cccc(OC(F)(F)F)c4)C2C=C3c5ccc(CO)cc5)c6cccs6)C1=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 P11 mock treatment 260550.0 -222000.0 -1.11 435840.0 -34200.0 -0.16 -0.8991 -0.8013 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 P12 mock treatment 271460.0 -211000.0 -1.06 461030.0 -9060.0 -0.04 -0.7768 -0.735 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 P13 compound treatment 159890.0 -323000.0 -1.61 163380.0 -307000.0 -1.44 -2.1608 -0.9984 3070937 BCB03_000308 COC(=O)[C@H](Cc1ccc(O)cc1)N2CC3=CCCC=C[C@@H]3[C@H]2[C@H](O)Cc4ccccc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 P14 compound treatment 303330.0 -180000.0 -0.9 353920.0 -116000.0 -0.55 -1.0205 -0.9718 3188387 BCB03_000309 COP(=O)(OC)/N=C\1/CC(=CC(C2CC2)N1C)CCCO 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 P15 compound treatment 217980.0 -265000.0 -1.32 166850.0 -303000.0 -1.43 -1.9441 -0.9993 3188528 BCB03_000310 Oc1ccc(C[C@@H]2N3CC4=CCCC=C[C@@H]4[C@H]3[C@@H](Cc5ccccc5)OC2=O)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 P16 compound treatment 244890.0 -238000.0 -1.19 364320.0 -106000.0 -0.5 -1.1923 -0.9253 3070122 BCB03_000311 COP(=O)(OC)/N=C\1/CC(=CC(N1C)c2ccc(CN3CCCC3)cc2)CCCO 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 P17 compound treatment 188640.0 -294000.0 -1.47 290880.0 -179000.0 -0.84 -1.6352 -0.9652 3188529 BCB03_000312 COC(=O)[C@H](Cc1ccccc1)N[C@@H](/C=C/C2CC2)[C@H](O)Cc3ccccc3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 P18 compound treatment 170620.0 -312000.0 -1.56 122050.0 -348000.0 -1.64 -2.2604 -0.9997 3188390 BCB03_000313 COP(=O)(OC)/N=C\1/CC(=CC(C2CC2)N1Cc3cc4OCOc4cc3Br)c5ccc(CO)cc5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 P19 compound treatment 197480.0 -285000.0 -1.43 229120.0 -241000.0 -1.13 -1.8094 -0.9935 3188530 BCB03_000314 COC(=O)[C@H](Cc1ccccc1)N(CC#C)[C@@H](/C=C/C2CC2)[C@H](O)Cc3ccccc3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 P20 compound treatment 255300.0 -228000.0 -1.14 204910.0 -265000.0 -1.25 -1.6857 -0.9989 3188503 BCB03_000315 COP(=O)(OC)/N=C\1/CC(=CC(C)N1Cc2cccc(OC(F)(F)F)c2)CCCO 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 P21 compound treatment 66900.0 -416000.0 -2.08 92960.0 -377000.0 -1.77 -2.7235 -0.9969 3070940 BCB03_000316 COC(=O)[C@H](Cc1ccccc1)N2CC(=C[C@H]2[C@H](O)Cc3ccccc3)/C=C/C4CC4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 P22 compound treatment 238100.0 -245000.0 -1.22 152610.0 -317000.0 -1.49 -1.9204 -0.9951 3070124 BCB03_000317 COP(=O)(OC)/N=C\1/CC(=CC(N1Cc2cc3OCOc3cc2Br)c4ccc(CN5CCCC5)cc4)CCCO 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 P23 compound treatment 165560.0 -317000.0 -1.58 186290.0 -284000.0 -1.33 -2.0646 -0.9964 3188533 BCB03_000318 O=C1O[C@@H](Cc2ccccc2)[C@@H](/C=C/C3CC3)N(CC#C)[C@H]1Cc4ccccc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2281 P24 compound treatment 89650.0 -393000.0 -1.96 87590.0 -382000.0 -1.8 -2.661 -0.999 3188506 BCB03_000319 COP(=O)(OC)/N=C\1/CC(=CC(C2CC2)N1Cc3sc4ccccc4c3Cl)c5ccc(CO)cc5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 A01 compound treatment 355250.0 -193000.0 -0.97 496610.0 45200.0 0.21 -0.533 -0.5388 3188507 BCB03_000320 CCCCCCc1nc(cc2CO[Si](C(C)C)(C(C)C)c21)c3ccc(o3)c4ccc(Cl)c(Cl)c4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 A02 compound treatment 503870.0 -44800.0 -0.22 518660.0 67200.0 0.32 0.0652 0.1684 3071186 BCB03_000321 COc1ccc(cc1)[C@H]2OC[C@@H]3CCC(=O)N23 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 A03 compound treatment 561650.0 13000.0 0.06 185550.0 -266000.0 -1.25 -0.8386 -0.6696 3070126 BCB03_000322 CCCCCCc1nc(cc2CO[Si](C(C)C)(C(C)C)c21)c3cc(C)c(OC)c(C)c3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 A04 compound treatment 535680.0 -13000.0 -0.06 503250.0 51800.0 0.24 0.1263 0.5009 3071252 BCB03_000323 COc1cccc(C[C@H]2C[C@@H](CO)NC2=O)c1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 A05 compound treatment 587060.0 38400.0 0.19 241600.0 -210000.0 -0.99 -0.5625 -0.5594 3070127 BCB03_000324 CCCCCCc1nc(cc2CO[Si](C(C)C)(C(C)C)c21)c3ccc(OC)nc3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 A06 compound treatment 519460.0 -29200.0 -0.15 464660.0 13200.0 0.06 -0.0593 -0.3738 3071181 BCB03_000325 COc1cccc(C[C@H]2C[C@@H](CO[Si](C(C)C)(C(C)C)C(C)C)N3C(=O)[C@]4(O[C@@]23[C@H]5[C@@H]4C(=O)N(C)C5=O)C(=O)C)c1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 A07 compound treatment 273690.0 -275000.0 -1.37 168570.0 -283000.0 -1.33 -1.9121 -0.9999 3070128 BCB03_000326 CCCCCCc1nc(Cc2cc(OC)c(OC)c(OC)c2)cc3CO[Si](C(C)C)(C(C)C)c31 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 A08 compound treatment 313730.0 -235000.0 -1.17 230160.0 -221000.0 -1.04 -1.5658 -0.9982 3189172 BCB03_000327 COc1cccc(C[C@H]2C[C@@H](CO[Si](C(C)C)(C(C)C)C(C)C)N3C(=O)[C@@]4(O[C@]23[C@@H]5[C@H]4C(=O)N(C)C5=O)C(=O)C)c1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 A09 compound treatment 552640.0 3950.0 0.02 540160.0 88700.0 0.42 0.309 0.7397 3070129 BCB03_000328 CCCCCCc1nc(cc2CO[Si](C(C)C)(C(C)C)c21)C3CC3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 A10 compound treatment 533150.0 -15500.0 -0.08 292160.0 -159000.0 -0.75 -0.5847 -0.7762 3071185 BCB03_000329 COc1ccc(cc1)[C@H]2OC[C@@H]3CC4(CC=CC4)C(=O)N23 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 A11 compound treatment 486940.0 -61800.0 -0.31 363580.0 -87900.0 -0.41 -0.5103 -0.9896 3188514 BCB03_000330 CCCCCCc1nc(c2ccc(o2)c3ccc(Cl)c(Cl)c3)c(C)c4CO[Si](C(C)C)(C(C)C)c41 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 A12 compound treatment 449920.0 -98800.0 -0.49 239120.0 -212000.0 -1.0 -1.055 -0.9471 3189173 BCB03_000331 NC(=N)NCc1cn(CCc2c[nH]c3ccccc23)nn1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 A13 mock treatment 471720.0 -77000.0 -0.38 368440.0 -83000.0 -0.39 -0.5479 -1.0 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 A14 mock treatment 497340.0 -51400.0 -0.26 493990.0 42500.0 0.2 -0.0399 -0.1226 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 A15 compound treatment 477640.0 -71100.0 -0.35 473290.0 21800.0 0.1 -0.1783 -0.4826 3070178 BCB03_000332 CCCCCCc1nc(c(C)c2CO[Si](C(C)C)(C(C)C)c21)c3cc(C)c(OC)c(C)c3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 A16 compound treatment 500160.0 -48500.0 -0.24 512980.0 61500.0 0.29 0.0332 0.088 3071253 BCB03_000333 COC(=O)c1c(CC[C@@H](CO)NC(=O)N(C)Cc2ccccc2)oc(C(=O)OCC=C)c1C(=O)OC 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 A17 compound treatment 497090.0 -51600.0 -0.26 531780.0 80300.0 0.38 0.0849 0.1857 3070179 BCB03_000334 CCCCCCc1nc(c(C)c2CO[Si](C(C)C)(C(C)C)c21)c3ccc(OC)nc3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 A18 compound treatment 525930.0 -22800.0 -0.11 392220.0 -59200.0 -0.28 -0.2774 -0.9219 3071184 BCB03_000335 COc1ccc(cc1)[C@H]2OC[C@@H]3C[C@@H](Cc4ccccc4)C(=O)N23 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 A19 compound treatment 442170.0 -107000.0 -0.53 309320.0 -142000.0 -0.67 -0.8489 -0.9936 3070180 BCB03_000336 CCCCCCc1nc(Cc2cc(OC)c(OC)c(OC)c2)c(C)c3CO[Si](C(C)C)(C(C)C)c31 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 A20 compound treatment 459140.0 -89600.0 -0.45 378400.0 -73100.0 -0.34 -0.5592 -0.9915 3071183 BCB03_000337 COc1ccc(cc1)[C@H]2OC[C@@H]3C[C@H](Cc4ccccc4)C(=O)N23 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 A21 compound treatment 478100.0 -70600.0 -0.35 475700.0 24200.0 0.11 -0.1687 -0.4551 3070181 BCB03_000338 CCCCCCc1nc(C2CC2)c(C)c3CO[Si](C(C)C)(C(C)C)c31 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 A22 compound treatment 501450.0 -47200.0 -0.24 301980.0 -149000.0 -0.7 -0.664 -0.8953 3189417 BCB03_000339 COC(=O)c1c(C(=O)OC)c2oc1CC[C@@H](CO)NC(=O)N[C@@H](Cc3ccccc3)Cn4cc(COC2=O)nn4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 A23 compound treatment 503330.0 -45400.0 -0.23 420500.0 -31000.0 -0.15 -0.2632 -0.9771 3188651 BCB03_000340 CCCCCCc1nc(cc2[C@@H](O[Si](C(C)C)(C(C)C)c21)c3ccccc3)c4ccc(o4)c5ccc(Cl)c(Cl)c5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 A24 compound treatment 435700.0 -113000.0 -0.56 344040.0 -107000.0 -0.51 -0.7563 -0.9985 3070196 BCB03_000341 CC(C)[C@@H](C(=O)O)n1cc(nn1)c2ccccn2 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 B01 compound treatment 355430.0 -193000.0 -0.97 327060.0 -124000.0 -0.59 -1.0963 -0.9712 3188662 BCB03_000342 COC(=O)[C@H](Cc1ccccc1)N2CC(=C[C@@H]2[C@@H](O)Cc3ccccc3)/C=C/C4CC4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 B02 compound treatment 363360.0 -185000.0 -0.93 364000.0 -87500.0 -0.41 -0.9454 -0.9333 3071724 BCB03_000343 BrC1=C[C@]23COC[C@H]3C[C@@H]1[C@]4(CO4)C2=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 B03 compound treatment 481530.0 -67200.0 -0.34 458950.0 7500.0 0.04 -0.2123 -0.6293 3188663 BCB03_000344 COC(=O)[C@H](Cc1ccccc1)N2CC(=C)[C@@H](/C=C/C=C)[C@@H]2[C@@H](O)Cc3ccccc3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 B04 compound treatment 431690.0 -117000.0 -0.58 356200.0 -95300.0 -0.45 -0.73 -0.9914 3071727 BCB03_000345 C[C@]12COC[C@@]2(C=C(Br)[C@@H]3C1)C(=O)[C@@]43CO4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 B05 compound treatment 566480.0 17800.0 0.09 309120.0 -142000.0 -0.67 -0.4106 -0.608 3070955 BCB03_000346 COC(=O)[C@H](Cc1ccccc1)N2CC(C)(OC)O[C@@H](Cc3ccccc3)[C@H]2/C=C/C4CC4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 B06 compound treatment 468240.0 -80500.0 -0.4 415050.0 -36400.0 -0.17 -0.4052 -0.9277 3071766 BCB03_000347 CCCCC[C@H]1OC[C@@]2(C=C(Br)[C@@H]3CC12)C(=O)[C@@]43CO4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 B07 compound treatment 516230.0 -32500.0 -0.16 505170.0 53700.0 0.25 0.064 0.2132 3188666 BCB03_000348 COC(=O)[C@H](Cc1ccccc1)N2CC3=C[C@@H](C4CC4)n5n([C@H]3[C@@H]2[C@@H](O)Cc6ccccc6)c(=O)n(C)c5=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 B08 compound treatment 479270.0 -69400.0 -0.35 482400.0 30900.0 0.15 -0.1422 -0.3782 3071767 BCB03_000349 CC1(C)OC[C@@]2(C=C(Br)[C@@H]3C[C@H]12)C(=O)[C@@]43CO4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 B09 compound treatment 595090.0 46400.0 0.23 506470.0 55000.0 0.26 0.3468 0.9985 3188667 BCB03_000350 O[C@@H](Cc1ccccc1)[C@@H](/C=C/C2CC2)N(CC#Cc3ccccc3)Cc4ccccc4Br 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 B10 compound treatment 409610.0 -139000.0 -0.69 378940.0 -72500.0 -0.34 -0.7324 -0.9464 3071770 BCB03_000351 BrC1=C[C@]23COCC[C@H]3C[C@@H]1[C@@]4(CO4)C2=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 B11 compound treatment 508910.0 -39800.0 -0.2 494270.0 42800.0 0.2 0.0019 0.0068 3188668 BCB03_000352 CCC#CCN(Cc1ccccc1Br)[C@H](/C=C/c2ccccc2)[C@@H](O)Cc3ccccc3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 B12 compound treatment 23860.0 -525000.0 -2.62 34850.0 -417000.0 -1.96 -3.2391 -0.9897 3071774 BCB03_000353 C=CCC1=C[C@H]2[C@H]([C@H]3C=C[C@]2(CC=C)C(=O)[C@@]43CO4)[C@@]5(CO5)C1=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 B13 mock treatment 559650.0 11000.0 0.05 510600.0 59100.0 0.28 0.2354 0.8303 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 B14 mock treatment 532160.0 -16500.0 -0.08 506030.0 54600.0 0.26 0.1231 0.4566 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 B15 compound treatment 546470.0 -2220.0 -0.01 341180.0 -110000.0 -0.52 -0.3746 -0.7221 3070996 BCB03_000354 O[C@@H](Cc1ccccc1)[C@@H](/C=C/c2ccccc2)N(CC#C)Cc3ccccc3Br 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 B16 compound treatment 29990.0 -519000.0 -2.59 25920.0 -426000.0 -2.0 -3.2472 -0.9919 3188527 BCB03_000355 CC1=C[C@]2(CO)C(=O)[C@]3(CO3)[C@H]1[C@@H]4[C@@]5(CO5)C(=O)C(=C[C@@]42C)CO 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 B17 compound treatment 512990.0 -35700.0 -0.18 494620.0 43200.0 0.2 0.0175 0.0647 3070997 BCB03_000356 CCCC/C=C/[C@H]([C@@H](O)Cc1ccccc1)N(CC#Cc2ccccc2)Cc3ccccc3Br 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 B18 compound treatment 500540.0 -48200.0 -0.24 362410.0 -89000.0 -0.42 -0.4662 -0.9653 3070938 BCB03_000357 CC(C)Cc1ccc(CN2CC[C@H](C2)NS(=O)(=O)c3cc(F)ccc3C)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 B19 compound treatment 523520.0 -25200.0 -0.13 455760.0 4310.0 0.02 -0.0746 -0.5855 3071055 BCB03_000358 CCC#CCN(Cc1ccccc1Br)[C@H](/C=C/C2CC2)[C@@H](O)Cc3ccccc3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 B20 compound treatment 388080.0 -161000.0 -0.8 405150.0 -46300.0 -0.22 -0.7212 -0.8677 3070939 BCB03_000359 Cc1ccc(F)cc1S(=O)(=O)N[C@@H]2CCN(Cc3ccc(cc3)c4ccccc4)C2 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 B21 compound treatment 240930.0 -308000.0 -1.54 384020.0 -67400.0 -0.32 -1.3112 -0.8354 3188794 BCB03_000360 O[C@@H](Cc1ccccc1)[C@H](NCc2cccc(Cl)c2)/C=C/C3CC3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 B22 compound treatment 468430.0 -80300.0 -0.4 438920.0 -12500.0 -0.06 -0.3251 -0.8024 3188531 BCB03_000361 Cc1ccc(F)cc1S(=O)(=O)N[C@@H]2CCN(Cc3ccc(Oc4ccccc4)cc3)C2 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 B23 compound treatment 521060.0 -27600.0 -0.14 368610.0 -82800.0 -0.39 -0.3731 -0.9026 3188796 BCB03_000362 O[C@@H](Cc1ccccc1)[C@@H](/C=C/C2CC2)N(CC#Cc3ccccc3)Cc4cccc(Cl)c4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 B24 compound treatment 497660.0 -51000.0 -0.25 441640.0 -9810.0 -0.05 -0.2129 -0.8218 3188532 BCB03_000363 Cc1ccc(F)cc1S(=O)(=O)N[C@@H]2CCN(Cc3ccc(cc3)C(F)(F)F)C2 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 C01 compound treatment 499040.0 -49700.0 -0.25 463550.0 12100.0 0.06 -0.1351 -0.531 3070235 BCB03_000364 CCCCCCc1nc(cc2[C@@H](O[Si](C(C)C)(C(C)C)c21)c3ccccc3)c4cc(C)c(OC)c(C)c4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 C02 compound treatment 519520.0 -29200.0 -0.15 449920.0 -1530.0 -0.01 -0.1081 -0.7411 3189039 BCB03_000365 OC(=O)[C@H](Cc1ccccc1)n2cc(nn2)c3ccccc3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 C03 compound treatment 508640.0 -40100.0 -0.2 512010.0 60600.0 0.28 0.06 0.1723 3070236 BCB03_000366 CCCCCCc1nc(cc2[C@@H](O[Si](C(C)C)(C(C)C)c21)c3ccccc3)c4ccc(OC)nc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 C04 compound treatment 521080.0 -27600.0 -0.14 455810.0 4360.0 0.02 -0.083 -0.5954 3070086 BCB03_000367 N[C@@H](Cc1ccccc1)C(=O)NCc2cn(CCCNC(=N)N)nn2 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 C05 compound treatment 552890.0 4200.0 0.02 232000.0 -219000.0 -1.03 -0.7151 -0.6926 3188655 BCB03_000368 CCCCCCc1nc(Cc2cc(OC)c(OC)c(OC)c2)cc3[C@@H](O[Si](C(C)C)(C(C)C)c31)c4ccccc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 C06 compound treatment 476490.0 -72200.0 -0.36 356760.0 -94700.0 -0.45 -0.5699 -0.9945 3070191 BCB03_000369 N[C@@H](Cc1ccccc1)C(=O)NCc2cn(Cc3ccccc3)nn2 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 C07 compound treatment 552990.0 4300.0 0.02 359130.0 -92300.0 -0.43 -0.2919 -0.6713 3188656 BCB03_000370 CCCCCCc1nc(cc2[C@@H](O[Si](C(C)C)(C(C)C)c21)c3ccccc3)C4CC4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 C08 compound treatment 533200.0 -15500.0 -0.08 467230.0 15800.0 0.07 -0.0022 -0.0209 3071180 BCB03_000371 OC(=O)[C@H](Cc1ccccc1)n2cc(nn2)c3ccccn3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 C09 compound treatment 511760.0 -36900.0 -0.18 416390.0 -35100.0 -0.16 -0.247 -0.9984 3188772 BCB03_000372 CCCCCCc1nc(CCCc2cc3[C@@H](O[Si](C(C)C)(C(C)C)c3c(CCCCCC)n2)c4ccccc4)cc5[C@@H](O[Si](C(C)C)(C(C)C)c51)c6ccccc6 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 C10 compound treatment 482810.0 -65900.0 -0.33 466470.0 15000.0 0.07 -0.1827 -0.5429 3070134 BCB03_000373 OC(=O)[C@H](Cc1ccccc1)n2cc(nn2)C3(O)CCCCC3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 C11 mock treatment 497440.0 -51300.0 -0.26 476370.0 24900.0 0.12 -0.0981 -0.3485 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 C12 mock treatment 497090.0 -51600.0 -0.26 376240.0 -75200.0 -0.35 -0.4324 -0.9879 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 C13 compound treatment 456160.0 -92500.0 -0.46 369170.0 -82300.0 -0.39 -0.6005 -0.9961 3070242 BCB03_000374 CC(C)[Si]1(OCc2cc(nc(c21)c3ccccc3)c4ccc(o4)c5ccc(Cl)c(Cl)c5)C(C)C 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 C14 compound treatment 514320.0 -34400.0 -0.17 454160.0 2710.0 0.01 -0.1124 -0.6528 3070089 BCB03_000375 CC(C)[C@@H](C(=O)O)n1cc(nn1)c2ccccc2 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 C15 mock treatment 500000.0 -48700.0 -0.24 453390.0 1940.0 0.01 -0.1655 -0.6801 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 C16 mock treatment 513970.0 -34700.0 -0.17 459360.0 7910.0 0.04 -0.0963 -0.5431 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 C17 compound treatment 510850.0 -37800.0 -0.19 448570.0 -2880.0 -0.01 -0.1432 -0.7559 3070245 BCB03_000376 COc1c(C)cc(cc1C)c2cc3CO[Si](C(C)C)(C(C)C)c3c(n2)c4ccccc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 C18 compound treatment 508810.0 -39900.0 -0.2 312830.0 -139000.0 -0.65 -0.6019 -0.8829 3071179 BCB03_000377 CC(C)[C@@H](C(=O)O)n1cc(nn1)C2(O)CCCCC2 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 C19 compound treatment 489850.0 -58800.0 -0.29 416320.0 -35100.0 -0.17 -0.3247 -0.9629 3070527 BCB03_000378 COc1cc(Cc2cc3CO[Si](C(C)C)(C(C)C)c3c(n2)c4ccccc4)cc(OC)c1OC 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 C20 compound treatment 428600.0 -120000.0 -0.6 433470.0 -18000.0 -0.08 -0.4839 -0.7989 3414058 BCB03_000379 COC(=O)c1c(C(=O)OC)c2oc1CC[C@@H](CO)NC(=O)N(C)Cc3cn(C[C@H](Cc4ccccc4)NC2=O)nn3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 C21 compound treatment 470740.0 -78000.0 -0.39 411470.0 -40000.0 -0.19 -0.4083 -0.9443 3070530 BCB03_000380 CC(C)[Si]1(OCc2cc(nc(c21)c3ccccc3)C4CC4)C(C)C 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 C22 compound treatment 469200.0 -79500.0 -0.4 455230.0 3780.0 0.02 -0.2682 -0.6748 3189555 BCB03_000381 COC(=O)c1c(C(=O)OC)c2oc1CC[C@@H](CO)NC(=O)N(Cc3ccccc3)Cc4cn(C[C@H](Cc5ccccc5)NC2=O)nn4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 C23 compound treatment 424770.0 -124000.0 -0.62 336440.0 -115000.0 -0.54 -0.8202 -0.9977 3070081 BCB03_000382 CC(C)[Si]1(OCc2c1c(nc(c3ccc(o3)c4ccc(Cl)c(Cl)c4)c2C)c5ccccc5)C(C)C 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 C24 compound treatment 477980.0 -70700.0 -0.35 389150.0 -62300.0 -0.29 -0.4569 -0.9957 3189558 BCB03_000383 COC(=O)c1c(C(=O)OC)c2oc1CC[C@@H](CO)NC(=O)N(Cc3ccccc3)Cc4cnnn4C[C@@H](Cc5ccccc5)NC2=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 D01 compound treatment 463050.0 -85600.0 -0.43 469080.0 17600.0 0.08 -0.2438 -0.5596 3071060 BCB03_000384 O[C@@H](Cc1ccccc1)[C@H](NCc2ccccc2Br)/C=C/c3ccccc3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 D02 compound treatment 504600.0 -44100.0 -0.22 437390.0 -14100.0 -0.07 -0.2025 -0.8806 3070941 BCB03_000385 Cc1ccc(F)cc1S(=O)(=O)N[C@@H]2CCN(Cc3ccc4[nH]ccc4c3)C2 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 D03 compound treatment 385440.0 -163000.0 -0.82 227680.0 -224000.0 -1.05 -1.3208 -0.992 3188797 BCB03_000386 O[C@@H](Cc1ccccc1)[C@H]2C3C=CCCC=C3CN2Cc4cccc(Cl)c4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 D04 compound treatment 464650.0 -84000.0 -0.42 337440.0 -114000.0 -0.54 -0.676 -0.9927 3070942 BCB03_000387 Cc1ccc(F)cc1S(=O)(=O)N[C@@H]2CCN(Cc3cccc4[nH]ccc34)C2 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 D05 compound treatment 628670.0 80000.0 0.4 516670.0 65200.0 0.31 0.4994 0.9915 3188798 BCB03_000388 COC1(C)CN(Cc2ccccc2Br)[C@H](/C=C/c3ccccc3)[C@H](Cc4ccccc4)O1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 D06 compound treatment 585930.0 37200.0 0.19 434200.0 -17300.0 -0.08 0.0741 0.3653 3070943 BCB03_000389 CC(C)Oc1ccc(cc1)C(=O)N2CC[C@H](C2)NS(=O)(=O)c3cc(F)ccc3C 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 D07 compound treatment 468770.0 -79900.0 -0.4 240640.0 -211000.0 -0.99 -0.9834 -0.92 3188799 BCB03_000390 CN1C(=O)C2C3[C@H]([C@@H](O)Cc4ccccc4)N(Cc5cccc(Cl)c5)CC3=CC(C6CC6)C2C1=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 D08 compound treatment 483520.0 -65200.0 -0.33 429370.0 -22100.0 -0.1 -0.3036 -0.8886 3188537 BCB03_000391 Cc1ccc(F)cc1S(=O)(=O)N[C@@H]2CCN(Cc3ccc(Br)cc3)C2 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 D09 compound treatment 569410.0 20700.0 0.1 368260.0 -83200.0 -0.39 -0.2035 -0.5029 3071066 BCB03_000392 O[C@@H](Cc1ccccc1)[C@H](N(CC#C)CC2=CCCCC2)c3ccccc3Br 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 D10 compound treatment 377370.0 -171000.0 -0.86 276680.0 -175000.0 -0.82 -1.1863 -0.9998 3070952 BCB03_000393 CC(C)Cc1ccc(CN2CC[C@@H](N)C2)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 D11 mock treatment 554190.0 5500.0 0.03 457190.0 5740.0 0.03 0.0385 1.0 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 D12 mock treatment 551140.0 2450.0 0.01 472590.0 21100.0 0.1 0.0789 0.7881 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 D13 compound treatment 498090.0 -50600.0 -0.25 485820.0 34400.0 0.16 -0.0644 -0.2147 3071068 BCB03_000394 O=C(Cc1ccccc1)[C@H]2C3C=CCCC(=C3CN2Cc4ccccc4)c5ccccc5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 D14 compound treatment 440000.0 -109000.0 -0.54 253700.0 -198000.0 -0.93 -1.0416 -0.9671 3070953 BCB03_000395 CC(C)Cc1ccc(CN2CC[C@H](C2)NS(=O)(=O)c3ccccc3)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 D15 mock treatment 545880.0 -2810.0 -0.01 472730.0 21300.0 0.1 0.0608 0.6019 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 D16 mock treatment 539960.0 -8730.0 -0.04 519240.0 67800.0 0.32 0.1946 0.6047 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 D17 compound treatment 210250.0 -338000.0 -1.69 151310.0 -300000.0 -1.41 -2.1935 -0.996 3071112 BCB03_000396 O[C@@H](Cc1ccccc1)[C@H]2C3C=CCCC(=C3CN2Cc4cccc(Cl)c4)c5ccccc5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 D18 compound treatment 488030.0 -60700.0 -0.3 433540.0 -17900.0 -0.08 -0.2738 -0.8707 3070954 BCB03_000397 CC(C)Cc1ccc(CN2CC[C@H](C2)NC(=O)c3ccccc3)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 D19 compound treatment 458820.0 -89900.0 -0.45 382960.0 -68500.0 -0.32 -0.5452 -0.9868 3188804 BCB03_000398 Clc1cccc(CN2CC3=CCCC=CC3[C@@H]2[C@H](Cc4ccccc4)OC(=O)C=C)c1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 D20 compound treatment 392000.0 -157000.0 -0.78 229690.0 -222000.0 -1.04 -1.291 -0.99 3188664 BCB03_000399 CC(C)Cc1ccc(CN2CC[C@H](C2)NC(=O)Nc3ccccc3)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 D21 compound treatment 156830.0 -392000.0 -1.96 118250.0 -333000.0 -1.57 -2.4921 -0.9939 3071454 BCB03_000400 CCC1=C2CN(Cc3ccccc3Br)[C@@H]([C@@H](O)Cc4ccccc4)C2C=CCC1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 D22 compound treatment 477920.0 -70800.0 -0.35 375860.0 -75600.0 -0.36 -0.5014 -1.0 3188665 BCB03_000401 CC(C)Oc1ccc(CN2CC[C@H](C2)NS(=O)(=O)c3cc(F)ccc3C)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 D23 compound treatment 478560.0 -70100.0 -0.35 439100.0 -12400.0 -0.06 -0.2888 -0.8133 3071455 BCB03_000402 CCC1=C2CN(Cc3ccccc3)[C@H](C2C=CCC1)C(=O)Cc4ccccc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 D24 compound treatment 496640.0 -52100.0 -0.26 413830.0 -37600.0 -0.18 -0.309 -0.9824 3070994 BCB03_000403 CC(C)Oc1ccc(CN2CC[C@@H](C2)NS(=O)(=O)c3cc(F)ccc3C)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 E01 mock treatment 540640.0 -8050.0 -0.04 539040.0 87600.0 0.41 0.2629 0.635 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 E02 mock treatment 590370.0 41700.0 0.21 490320.0 38900.0 0.18 0.2765 0.9979 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 E03 compound treatment 558340.0 9650.0 0.05 532320.0 80900.0 0.38 0.303 0.7904 3189040 BCB03_000404 COc1c(C)cc(cc1C)c2nc(c3c(CO[Si]3(C(C)C)C(C)C)c2C)c4ccccc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 E04 compound treatment 603330.0 54600.0 0.27 458130.0 6680.0 0.03 0.2152 0.7833 3189560 BCB03_000405 COC(=O)c1c(C(=O)OC)c2oc1CC[C@@H](CO)NC(=O)N(Cc3ccccc3)Cc4cn(C[C@@H]5CCCN5C2=O)nn4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 E05 compound treatment 615060.0 66400.0 0.33 547910.0 96500.0 0.45 0.5552 0.9881 3189041 BCB03_000406 COc1ccc(cn1)c2nc(c3c(CO[Si]3(C(C)C)C(C)C)c2C)c4ccccc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 E06 compound treatment 615070.0 66400.0 0.33 253820.0 -198000.0 -0.93 -0.4229 -0.4285 3189559 BCB03_000407 COC(=O)c1c(C(=O)OC)c2oc1CC[C@@H](CO)NC(=O)N(Cc3ccccc3)Cc4cnnn4C[C@@H]5CCCN5C2=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 E07 compound treatment 536450.0 -12200.0 -0.06 249020.0 -202000.0 -0.95 -0.7165 -0.751 3189042 BCB03_000408 CC(C)[Si]1(O[C@H](c2cc(nc(c21)c3ccccc3)c4ccc(o4)c5ccc(Cl)c(Cl)c5)c6ccccc6)C(C)C 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 E08 compound treatment 621570.0 72900.0 0.36 488430.0 37000.0 0.17 0.3804 0.9429 3189043 BCB03_000409 N[C@@H](Cc1ccccc1)Cn2cc(nn2)C3(O)CCCCC3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 E09 mock treatment 575450.0 26800.0 0.13 451900.0 450.0 0.0 0.096 0.7182 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 E10 mock treatment 584810.0 36100.0 0.18 498880.0 47400.0 0.22 0.2853 0.9944 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 E11 compound treatment 542570.0 -6120.0 -0.03 503320.0 51900.0 0.24 0.1509 0.6137 3070137 BCB03_000410 COc1c(C)cc(cc1C)c2cc3[C@@H](O[Si](C(C)C)(C(C)C)c3c(n2)c4ccccc4)c5ccccc5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 E12 compound treatment 203430.0 -345000.0 -1.72 319120.0 -132000.0 -0.62 -1.6595 -0.9052 3070143 BCB03_000411 N[C@@H](Cc1ccccc1)Cn2cc(nn2)c3ccccc3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 E13 compound treatment 534240.0 -14500.0 -0.07 497310.0 45900.0 0.22 0.1015 0.4461 3189044 BCB03_000412 COc1ccc(cn1)c2cc3[C@@H](O[Si](C(C)C)(C(C)C)c3c(n2)c4ccccc4)c5ccccc5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 E14 compound treatment 548880.0 186.0 0.0 498920.0 47500.0 0.22 0.1585 0.71 3189695 BCB03_000413 COC(=O)c1nc2oc1CC[C@@H](CO)NC(=O)N(C)Cc3cn(C[C@H](Cc4ccccc4)NC2=O)nn3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 E15 compound treatment 525890.0 -22800.0 -0.11 530090.0 78600.0 0.37 0.181 0.4677 3189045 BCB03_000414 CC(C)[Si]1(O[C@H](c2cc(nc(c21)c3ccccc3)C4CC4)c5ccccc5)C(C)C 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 E16 compound treatment 551790.0 3100.0 0.02 477150.0 25700.0 0.12 0.0964 0.7911 3071393 BCB03_000415 COC(=O)c1nc2oc1CC[C@@H](CO)NC(=O)N(C)Cc3cnnn3C[C@H](Cc4ccccc4)NC2=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 E17 mock treatment 508550.0 -40100.0 -0.2 332430.0 -119000.0 -0.56 -0.5376 -0.9041 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 E18 mock treatment 502020.0 -46700.0 -0.23 279360.0 -172000.0 -0.81 -0.7372 -0.8752 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 E19 compound treatment 459210.0 -89500.0 -0.45 214440.0 -237000.0 -1.11 -1.1043 -0.9195 3189046 BCB03_000416 CC(C)[Si]1(OCc2cc(nc(CCc3ccccc3)c21)c4ccc(o4)c5ccc(Cl)c(Cl)c5)C(C)C 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 E20 compound treatment 494460.0 -54200.0 -0.27 489860.0 38400.0 0.18 -0.0638 -0.1959 3071396 BCB03_000417 COC(=O)c1c(C(=O)OC)c2oc1CC[C@@H](CO)NC(=O)NC3(CCCCC3)c4cn(C[C@H](C)NC2=O)nn4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 E21 compound treatment 459750.0 -88900.0 -0.44 370120.0 -81300.0 -0.38 -0.5846 -0.9972 3189047 BCB03_000418 COc1c(C)cc(cc1C)c2cc3CO[Si](C(C)C)(C(C)C)c3c(CCc4ccccc4)n2 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 E22 compound treatment 538030.0 -10700.0 -0.05 426240.0 -25200.0 -0.12 -0.1215 -0.9347 3187595 BCB03_000419 COC(=O)c1c(C(=O)OC)c2oc1CC[C@@H](CO)NC(=O)NC3(CCCCC3)c4cn(C[C@@H](NC2=O)C(C)C)nn4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 E23 compound treatment 360370.0 -188000.0 -0.94 433190.0 -18300.0 -0.09 -0.7258 -0.7685 3189169 BCB03_000420 COc1ccc(cn1)c2cc3CO[Si](C(C)C)(C(C)C)c3c(CCc4ccccc4)n2 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 E24 compound treatment 524240.0 -24500.0 -0.12 426890.0 -24600.0 -0.12 -0.1681 -0.9996 3187594 BCB03_000421 COC(=O)c1c(C(=O)OC)c2oc1CC[C@@H](CO)NC(=O)NC3(CCCCC3)c4cn(C[C@H](Cc5ccccc5)NC2=O)nn4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 F01 mock treatment 539410.0 -9280.0 -0.05 544680.0 93200.0 0.44 0.2773 0.6288 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 F02 mock treatment 577410.0 28700.0 0.14 414360.0 -37100.0 -0.17 -0.0219 -0.0972 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 F03 compound treatment 477890.0 -70800.0 -0.35 403800.0 -47700.0 -0.22 -0.4085 -0.9758 3071456 BCB03_000422 C/C=C\[C@@H](NCc1ccccc1Br)[C@@H](O)Cc2ccccc2 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 F04 compound treatment 528020.0 -20700.0 -0.1 428700.0 -22800.0 -0.11 -0.1487 -0.9998 3070995 BCB03_000423 Cc1ccc(F)cc1S(=O)(=O)N[C@@H]2CCN(Cc3ccc4OCOc4c3)C2 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 F05 compound treatment 514420.0 -34300.0 -0.17 436750.0 -14700.0 -0.07 -0.1699 -0.9205 3071457 BCB03_000424 CC(=CCN[C@H](CO)c1ccccc1)C 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 F06 compound treatment 580360.0 31700.0 0.16 467100.0 15600.0 0.07 0.1639 0.9394 2133134 BCB03_000425 CCCCC(=O)N(CCN1CCOCC1)[C@@H]2CC(=C[C@H](Oc3c(I)cc(CO)cc3OC)[C@H]2O)C(=O)NCCO 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 F07 compound treatment 572160.0 23500.0 0.12 316240.0 -135000.0 -0.64 -0.3668 -0.5672 3071458 BCB03_000426 CC(=CCN(CC#C)[C@H](CO)c1ccccc1)C 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 F08 compound treatment 576490.0 27800.0 0.14 411800.0 -39700.0 -0.19 -0.0337 -0.145 2133147 BCB03_000427 COc1cc(CO)cc(I)c1O[C@H]2C=C(C[C@H]([C@@H]2O)N(CCN3CCOCC3)C(=O)C4CCCO4)C(=O)NCCO 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 F09 mock treatment 548480.0 -214.0 0.0 529920.0 78500.0 0.37 0.2602 0.7051 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 F10 mock treatment 559590.0 10900.0 0.05 397530.0 -53900.0 -0.25 -0.1409 -0.543 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 F11 compound treatment 368130.0 -181000.0 -0.9 193480.0 -258000.0 -1.21 -1.4957 -0.9893 3187737 BCB03_000428 CC(=CCN(CC#Cc1ccccc1)[C@H](CO)c2ccccc2)C 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 F12 compound treatment 492480.0 -56200.0 -0.28 317550.0 -134000.0 -0.63 -0.6439 -0.9337 3188671 BCB03_000429 COc1cc(CO)cc(I)c1O[C@H]2C=C(C[C@@H](NCCc3c[nH]c4ccccc34)[C@@H]2O)C(=O)NCCO 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 F13 compound treatment 505940.0 -42800.0 -0.21 481140.0 29700.0 0.14 -0.0522 -0.2048 3071460 BCB03_000430 O=C1OC[C@@H](c2ccccc2)n3cc(/C=C/c4ccccc4)cc13 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 F14 compound treatment 434790.0 -114000.0 -0.57 303790.0 -148000.0 -0.69 -0.8934 -0.9951 2129060 BCB03_000431 COc1cc(CO)cc(I)c1O[C@H]2C=C(C[C@@H](NCC3CCCCC3)[C@@H]2O)C(=O)NCCO 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 F15 compound treatment 528640.0 -20100.0 -0.1 433620.0 -17800.0 -0.08 -0.1301 -0.9961 3071461 BCB03_000432 CC(=C)C/1CN([C@H](CO)c2ccccc2)C(=O)\C1=C/c3ccccc3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 F16 compound treatment 523360.0 -25300.0 -0.13 476990.0 25500.0 0.12 -0.0045 -0.0259 2129057 BCB03_000433 COc1cc(CO)cc(I)c1O[C@H]2C=C(C[C@@H](NC[C@@H]3CCCO3)[C@@H]2O)C(=O)NCCO 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 F17 mock treatment 466910.0 -81800.0 -0.41 493560.0 42100.0 0.2 -0.1488 -0.3277 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 F18 mock treatment 264280.0 -284000.0 -1.42 468670.0 17200.0 0.08 -0.9472 -0.6657 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 F19 compound treatment 497540.0 -51200.0 -0.26 305040.0 -146000.0 -0.69 -0.6676 -0.9089 3071462 BCB03_000434 OCC(/C=C/c1ccccc1)N(CC#C)C(C(=O)O)c2ccccc2 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 F20 compound treatment 184640.0 -364000.0 -1.82 185960.0 -265000.0 -1.25 -2.1687 -0.9832 2129061 BCB03_000435 COc1cc(CO)cc(I)c1O[C@H]2C=C(C[C@@H](NC3CCCCCC3)[C@@H]2O)C(=O)NCCO 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 F21 compound treatment 462820.0 -85900.0 -0.43 233650.0 -218000.0 -1.02 -1.0277 -0.9253 3071463 BCB03_000436 C/C=C/CN([C@H](CO[Si](C)(C)C(C)(C)C)c1ccccc1)C(=O)C#Cc2ccccc2 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 F22 compound treatment 518480.0 -30200.0 -0.15 445960.0 -5490.0 -0.03 -0.125 -0.8163 2129067 BCB03_000437 COc1cc(CO)cc(I)c1O[C@H]2C=C(C[C@@H](NCc3ccccc3F)[C@@H]2O)C(=O)NCCO 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 F23 compound treatment 511120.0 -37600.0 -0.19 454170.0 2720.0 0.01 -0.1237 -0.6574 3071464 BCB03_000438 O=C1OC[C@H](N(CC#C)C1/C=C/c2ccccc2)c3ccccc3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 F24 compound treatment 279790.0 -269000.0 -1.34 242440.0 -209000.0 -0.98 -1.6448 -0.9882 2129068 BCB03_000439 COc1cc(CO)cc(I)c1O[C@H]2C=C(C[C@@H](NCc3ccc(F)cc3)[C@@H]2O)C(=O)NCCO 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 G01 compound treatment 523520.0 -25200.0 -0.13 525710.0 74300.0 0.35 0.1581 0.4258 3189170 BCB03_000440 COc1cc(Cc2cc3CO[Si](C(C)C)(C(C)C)c3c(CCc4ccccc4)n2)cc(OC)c1OC 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 G02 compound treatment 589040.0 40300.0 0.2 550410.0 99000.0 0.47 0.4716 0.9298 3187594 BCB03_000441 COC(=O)c1c(C(=O)OC)c2oc1CC[C@@H](CO)NC(=O)NC3(CCCCC3)c4cn(C[C@H](Cc5ccccc5)NC2=O)nn4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 G03 mock treatment 606080.0 57400.0 0.29 564490.0 113000.0 0.53 0.5786 0.958 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 G04 mock treatment 618100.0 69400.0 0.35 535580.0 84100.0 0.4 0.5249 0.9978 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 G05 compound treatment 622730.0 74000.0 0.37 566880.0 115000.0 0.54 0.6454 0.9825 3189171 BCB03_000442 CC(C)[Si]1(OCc2cc(nc(CCc3ccccc3)c21)C4CC4)C(C)C 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 G06 compound treatment 590310.0 41600.0 0.21 523270.0 71800.0 0.34 0.3858 0.9728 3187597 BCB03_000443 COC(=O)c1c(C(=O)OC)c2oc1CC[C@@H](CO)NC(=O)NC3(CCCCC3)c4cnnn4C[C@@H](NC2=O)C(C)C 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 G07 compound treatment 593240.0 44500.0 0.22 525770.0 74300.0 0.35 0.4045 0.9762 3071182 BCB03_000444 CC(C)[Si]1(OCc2cc(CCCc3cc4CO[Si](C(C)C)(C(C)C)c4c(CCc5ccccc5)n3)nc(CCc6ccccc6)c21)C(C)C 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 G08 compound treatment 574130.0 25400.0 0.13 272870.0 -179000.0 -0.84 -0.5041 -0.5934 3189696 BCB03_000445 COC(=O)c1c(C(=O)OC)c2oc1CC[C@@H](CO)NC(=O)NC3(CCCCC3)c4cn(C[C@@H](Cc5ccccc5)NC2=O)nn4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 G09 compound treatment 490600.0 -58100.0 -0.29 281850.0 -170000.0 -0.8 -0.7693 -0.9062 3189286 BCB03_000446 CC(C)[Si]1(O[C@H](c2cc(nc(CCc3ccccc3)c21)c4ccc(o4)c5ccc(Cl)c(Cl)c5)c6ccccc6)C(C)C 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 G10 compound treatment 583740.0 35000.0 0.18 372200.0 -79300.0 -0.37 -0.1398 -0.3395 3187593 BCB03_000447 COC(=O)c1c(C(=O)OC)c2oc1CC[C@@H](CO)NC(=O)NC3(CCCCC3)c4cnnn4C[C@@H](Cc5ccccc5)NC2=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 G11 compound treatment 520480.0 -28200.0 -0.14 246630.0 -205000.0 -0.96 -0.7809 -0.802 3189287 BCB03_000448 COc1c(C)cc(cc1C)c2cc3[C@@H](O[Si](C(C)C)(C(C)C)c3c(CCc4ccccc4)n2)c5ccccc5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 G12 compound treatment 544980.0 -3710.0 -0.02 488900.0 37400.0 0.18 0.1114 0.6292 3414059 BCB03_000449 COC(=O)c1c(C(=O)OC)c2oc1CC[C@@H](CO)NC(=O)N[C@@H](Cc3ccccc3)Cn4cc(CN(Cc5ccccc5)C2=O)nn4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 G13 compound treatment 528420.0 -20300.0 -0.1 283910.0 -168000.0 -0.79 -0.6288 -0.7915 3189288 BCB03_000450 COc1ccc(cn1)c2cc3[C@@H](O[Si](C(C)C)(C(C)C)c3c(CCc4ccccc4)n2)c5ccccc5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 G14 compound treatment 537810.0 -10900.0 -0.05 532110.0 80700.0 0.38 0.2298 0.5997 3414060 BCB03_000451 COC(=O)c1c(C(=O)OC)c2oc1CC[C@@H](CO)NC(=O)N[C@@H](Cc3ccccc3)Cn4cc(nn4)C5(CCCCC5)NC2=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 G15 compound treatment 454330.0 -94400.0 -0.47 166130.0 -285000.0 -1.34 -1.2822 -0.9015 3189289 BCB03_000452 COc1cc(Cc2cc3[C@@H](O[Si](C(C)C)(C(C)C)c3c(CCc4ccccc4)n2)c5ccccc5)cc(OC)c1OC 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 G16 compound treatment 557650.0 8960.0 0.04 511120.0 59700.0 0.28 0.2301 0.8096 3189561 BCB03_000453 CN1Cc2cn(C[C@H](Cc3ccccc3)NC(=O)c4cc(c(CC[C@@H](CO)NC1=O)o4)S(=O)(=O)c5ccc(C)cc5)nn2 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 G17 compound treatment 548800.0 106.0 0.0 430270.0 -21200.0 -0.1 -0.0701 -0.7033 3189171 BCB03_000454 CC(C)[Si]1(OCc2cc(nc(CCc3ccccc3)c21)C4CC4)C(C)C 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 G18 compound treatment 593640.0 44900.0 0.22 489360.0 37900.0 0.18 0.2848 0.9935 3189290 BCB03_000455 COc1ccc(cc1)[C@H]2OC[C@@H]3CC(CC=C)(CC=C)C(=O)N23 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 G19 mock treatment 508450.0 -40200.0 -0.2 416000.0 -35500.0 -0.17 -0.26 -0.9957 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 G20 mock treatment 282260.0 -266000.0 -1.33 505280.0 53800.0 0.25 -0.7619 -0.5625 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 G21 compound treatment 315070.0 -234000.0 -1.17 478820.0 27400.0 0.13 -0.734 -0.6253 3071182 BCB03_000456 CC(C)[Si]1(OCc2cc(CCCc3cc4CO[Si](C(C)C)(C(C)C)c4c(CCc5ccccc5)n3)nc(CCc6ccccc6)c21)C(C)C 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 G22 compound treatment 503310.0 -45400.0 -0.23 431360.0 -20100.0 -0.09 -0.2271 -0.9248 3071255 BCB03_000457 NC(=N)NCC#C 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 G23 compound treatment 517660.0 -31000.0 -0.16 431900.0 -19600.0 -0.09 -0.1746 -0.9689 3188910 BCB03_000458 CC(C)[Si]1(OCc2cc(nc(c21)c3ccc(Oc4ccccc4)cc3)c5ccc(o5)c6ccc(Cl)c(Cl)c6)C(C)C 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 G24 compound treatment 508850.0 -39800.0 -0.2 247230.0 -204000.0 -0.96 -0.8199 -0.8358 3189419 BCB03_000459 OC(=O)CCC(=O)N[C@@H](Cc1ccccc1)C(=O)NCC#C 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 H01 compound treatment 414480.0 -134000.0 -0.67 382000.0 -69500.0 -0.33 -0.705 -0.9454 3071464 BCB03_000460 O=C1OC[C@H](N(CC#C)C1/C=C/c2ccccc2)c3ccccc3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 H02 compound treatment 603680.0 55000.0 0.27 553470.0 102000.0 0.48 0.5335 0.9649 3071064 BCB03_000461 CCCC(=O)N(CCc1c[nH]c2ccccc12)[C@@H]3CC(=C[C@H](Oc4c(I)cc(CO)cc4OC)[C@H]3O)C(=O)NCCO 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 H03 mock treatment 599520.0 50800.0 0.25 547840.0 96400.0 0.45 0.5001 0.9624 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 H04 mock treatment 598030.0 49300.0 0.25 430740.0 -20700.0 -0.1 0.1054 0.3976 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 H05 compound treatment 593520.0 44800.0 0.22 152980.0 -298000.0 -1.4 -0.8344 -0.5869 3071517 BCB03_000462 CC(=C)C1C(=C)CN([C@H](CO)c2ccccc2)C1=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 H06 compound treatment 629700.0 81000.0 0.4 192530.0 -259000.0 -1.22 -0.5751 -0.4481 2133032 BCB03_000463 COc1cc(CO)cc(I)c1O[C@H]2C=C(C[C@H]([C@@H]2O)N(CC3CCCCC3)C(=O)c4ccc(cc4)C(F)(F)F)C(=O)NCCO 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 H07 compound treatment 619290.0 70600.0 0.35 532270.0 80800.0 0.38 0.5181 0.9993 3187880 BCB03_000464 CC(C)(C)OC(=O)N(CC#C)[C@H](CO)c1ccccc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 H08 compound treatment 594660.0 46000.0 0.23 246660.0 -205000.0 -0.96 -0.5188 -0.5239 2133035 BCB03_000465 COc1cc(CO)cc(I)c1O[C@H]2C=C(C[C@H]([C@@H]2O)N(CC3CCCCC3)C(=O)c4cc5ccccc5oc4=O)C(=O)NCCO 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 H09 compound treatment 33940.0 -515000.0 -2.57 11280.0 -440000.0 -2.07 -3.2819 -0.9942 3071519 BCB03_000466 CC(=CCN([C@H](CO)c1ccccc1)C(=O)C#Cc2ccccc2)C 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 H10 compound treatment 544570.0 -4120.0 -0.02 195250.0 -256000.0 -1.21 -0.8667 -0.7191 2133267 BCB03_000467 COc1cc(CO)cc(I)c1O[C@H]2C=C(C[C@H]([C@@H]2O)N(Cc3ccc(F)cc3)C(=O)C4CCCO4)C(=O)NCCO 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 H11 compound treatment 447380.0 -101000.0 -0.51 116810.0 -335000.0 -1.57 -1.4708 -0.8896 3071520 BCB03_000468 OC[C@@H](N(C/C=C/c1ccccc1)CC#C)c2ccccc2 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 H12 compound treatment 549930.0 1240.0 0.01 357620.0 -93800.0 -0.44 -0.3077 -0.6971 2133153 BCB03_000469 COc1cc(CO)cc(I)c1O[C@H]2C=C(C[C@H]([C@@H]2O)N(CCN3CCOCC3)C(=O)C4CCOC4)C(=O)NCCO 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 H13 compound treatment 600770.0 52100.0 0.26 531750.0 80300.0 0.38 0.451 0.9834 3071521 BCB03_000470 CC(C)(C)[Si](C)(C)OC[C@@H](N(C/C=C/c1ccccc1)CC#C)c2ccccc2 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 H14 compound treatment 552990.0 4300.0 0.02 486130.0 34700.0 0.16 0.1305 0.7933 2132929 BCB03_000471 CC/C=C/C(=O)N(C[C@@H]1CCCO1)[C@@H]2CC(=C[C@H](Oc3c(I)cc(CO)cc3OC)[C@H]2O)C(=O)NCCO 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 H15 compound treatment 538320.0 -10400.0 -0.05 411240.0 -40200.0 -0.19 -0.1704 -0.8688 3071522 BCB03_000472 O=C1OC[C@H](N2CC(=CC21)/C=C/c3ccccc3)c4ccccc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 H16 compound treatment 574120.0 25400.0 0.13 443200.0 -8250.0 -0.04 0.0624 0.4696 2133065 BCB03_000473 COc1cc(CO)cc(I)c1O[C@H]2C=C(C[C@H]([C@@H]2O)N(C3CCCCCC3)C(=O)c4cc5ccccc5oc4=O)C(=O)NCCO 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 H17 compound treatment 595010.0 46300.0 0.23 413980.0 -37500.0 -0.18 0.0389 0.1339 3071523 BCB03_000474 OCC(/C=C/c1ccccc1)N(CC#C)Cc2ccccc2Br 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 H18 compound treatment 560730.0 12000.0 0.06 449290.0 -2160.0 -0.01 0.0353 0.5794 2133224 BCB03_000475 CCCCC(=O)N(Cc1ccccc1F)[C@@H]2CC(=C[C@H](Oc3c(I)cc(CO)cc3OC)[C@H]2O)C(=O)NCCO 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 H19 mock treatment 555070.0 6380.0 0.03 236570.0 -215000.0 -1.01 -0.6922 -0.6845 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 H20 mock treatment 568420.0 19700.0 0.1 488890.0 37400.0 0.18 0.1942 0.9623 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 H21 compound treatment 476880.0 -71800.0 -0.36 190780.0 -261000.0 -1.23 -1.1206 -0.8772 3071524 BCB03_000476 OCC1C=C(CN1Cc2ccccc2Br)/C=C/c3ccccc3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 H22 compound treatment 519580.0 -29100.0 -0.15 345940.0 -106000.0 -0.5 -0.4537 -0.8774 2133510 BCB03_000477 COc1cc(CO)cc(I)c1O[C@H]2C=C(C[C@H]([C@@H]2O)N(CCc3cccc(F)c3)C(=O)CCC4CCCC4)C(=O)NCCO 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 H23 compound treatment 515470.0 -33200.0 -0.17 417760.0 -33700.0 -0.16 -0.2294 -0.9997 3414064 BCB03_000478 O=S1(=O)N2CCC[C@@H]2[C@@H](Oc3ccccc31)C#C 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 H24 compound treatment 520660.0 -28000.0 -0.14 288720.0 -163000.0 -0.77 -0.6402 -0.8228 2128988 BCB03_000479 COc1cc(CO)cc(I)c1O[C@H]2C=C(C[C@@H]3O[C@@H]32)C(=O)NCCO 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 I01 compound treatment 581640.0 32900.0 0.16 579680.0 128000.0 0.6 0.5428 0.8683 3070742 BCB03_000480 COc1c(C)cc(cc1C)c2cc3CO[Si](C(C)C)(C(C)C)c3c(n2)c4ccc(Oc5ccccc5)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 I02 compound treatment 580320.0 31600.0 0.16 399940.0 -51500.0 -0.24 -0.0596 -0.2062 3189420 BCB03_000481 COc1ccc(cc1)[C@H]2OC[C@@H]3C[C@](Cc4ccccc4)(C(=O)OCC=C)C(=O)N23 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 I03 compound treatment 590400.0 41700.0 0.21 451120.0 -330.0 0.0 0.1462 0.7018 3070750 BCB03_000482 COc1ccc(cn1)c2cc3CO[Si](C(C)C)(C(C)C)c3c(n2)c4ccc(Oc5ccccc5)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 I04 compound treatment 616590.0 67900.0 0.34 522750.0 71300.0 0.34 0.4769 1.0 1035256 BCB03_000483 C#CCNCc1ccccc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 I05 mock treatment 636580.0 87900.0 0.44 167540.0 -284000.0 -1.34 -0.6339 -0.4509 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 I06 mock treatment 606020.0 57300.0 0.29 432360.0 -19100.0 -0.09 0.139 0.4631 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 I07 compound treatment 575850.0 27200.0 0.14 536390.0 84900.0 0.4 0.3784 0.8969 3188915 BCB03_000484 CC(C)[Si]1(OCc2cc(nc(c21)c3ccc(Oc4ccccc4)cc3)C5CC5)C(C)C 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 I08 compound treatment 581510.0 32800.0 0.16 227300.0 -224000.0 -1.05 -0.6296 -0.5901 3071258 BCB03_000485 CC(C)[C@H](N=[N+]=[N-])C(=O)N[C@@H](Cc1ccccc1)C(=O)NCC#C 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 I09 compound treatment 560380.0 11700.0 0.06 496960.0 45500.0 0.21 0.1926 0.8682 3070808 BCB03_000486 CC(C)[Si]1(O[C@H](c2cc(nc(c21)c3ccc(Oc4ccccc4)cc3)C5CC5)c6ccccc6)C(C)C 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 I10 compound treatment 574940.0 26200.0 0.13 449200.0 -2250.0 -0.01 0.0852 0.6479 3189550 BCB03_000487 COc1cccc(C[C@]2(C[C@@H](CO)NC2=O)C(=O)OCc3ccccc3)c1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 I11 compound treatment 594250.0 45600.0 0.23 161300.0 -290000.0 -1.36 -0.8041 -0.5812 3070078 BCB03_000488 CC[C@@H]1O[Si](C(C)C)(C(C)C)c2c1cc(nc2c3ccc(Oc4ccccc4)cc3)c5cc(C)c(OC)c(C)c5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 I12 compound treatment 477550.0 -71100.0 -0.36 491040.0 39600.0 0.19 -0.1196 -0.2981 3189551 BCB03_000489 COc1cccc(C[C@@]2(C[C@@H](CO)NC2=O)C(=O)OCc3ccccc3)c1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 I13 compound treatment 496960.0 -51700.0 -0.26 237340.0 -214000.0 -1.01 -0.8948 -0.8607 3070690 BCB03_000490 CCCCCCc1nc(cc2CO[Si](C(C)C)(C(C)C)c21)C(=C)C 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 I14 compound treatment 578750.0 30100.0 0.15 478500.0 27000.0 0.13 0.1961 0.9966 3071267 BCB03_000491 CN(C)S(=O)(=O)NCC#C 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 I15 compound treatment 497990.0 -50700.0 -0.25 225990.0 -225000.0 -1.06 -0.9289 -0.852 3071259 BCB03_000492 CC(C)[Si](O[C@@H](c1cn(Cc2ccccc2)nn1)c3ccccc3)(C#Cc4ccccc4)C(C)C 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 I16 compound treatment 473730.0 -75000.0 -0.37 371750.0 -79700.0 -0.37 -0.5298 -1.0 3189556 BCB03_000493 COC(=O)c1c(C(=O)OC)c2oc1CC[C@@H](CO)NC(=O)N(Cc3ccccc3)Cc4cn(C[C@@H](Cc5ccccc5)NC2=O)nn4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 I17 compound treatment 529200.0 -19500.0 -0.1 190960.0 -260000.0 -1.23 -0.9352 -0.7609 3071266 BCB03_000494 CC(C)[Si](O[C@@H](c1cn(Cc2ccccc2)nn1)c3ccccc3)(C#CCCc4ccccc4)C(C)C 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 I18 compound treatment 572090.0 23400.0 0.12 492550.0 41100.0 0.19 0.2193 0.9709 3188911 BCB03_000495 COC(=O)c1c(C(=O)OC)c2oc1CC[C@@H](CO)NC(=O)N[C@H](Cc3ccccc3)Cn4cc(CN(C)C2=O)nn4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 I19 compound treatment 538300.0 -10400.0 -0.05 357120.0 -94300.0 -0.44 -0.3504 -0.7845 3189415 BCB03_000496 CCCCCCC#C[Si](O[C@@H](C#C)c1ccccc1)(C(C)C)C(C)C 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 I20 compound treatment 555040.0 6350.0 0.03 454650.0 3200.0 0.02 0.0331 0.9421 3188912 BCB03_000497 COC(=O)c1c(C(=O)OC)c2oc1CC[C@@H](CO)NC(=O)N[C@H](C)Cn3cc(CN(C)C2=O)nn3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 I21 mock treatment 508600.0 -40100.0 -0.2 373280.0 -78200.0 -0.37 -0.4016 -0.9592 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 I22 mock treatment 530730.0 -18000.0 -0.09 402250.0 -49200.0 -0.23 -0.2271 -0.9149 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 I23 compound treatment 453360.0 -95300.0 -0.48 210260.0 -241000.0 -1.13 -1.1389 -0.9257 3189416 BCB03_000498 CCCCCCC#C[Si](OCC#CC)(C(C)C)C(C)C 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 I24 compound treatment 557150.0 8460.0 0.04 260290.0 -191000.0 -0.9 -0.6059 -0.6732 3188913 BCB03_000499 COC(=O)c1c(C(=O)OC)c2oc1CC[C@@H](CO)NC(=O)N[C@@H](Cc3ccccc3)Cn4cc(CN(C)C2=O)nn4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 J01 compound treatment 547040.0 -1650.0 -0.01 459760.0 8310.0 0.04 0.0218 0.5456 3071594 BCB03_000500 O=S1(=O)N2CCC[C@H]2[C@H](Oc3ccccc31)C#C 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 J02 compound treatment 623900.0 75200.0 0.38 521390.0 69900.0 0.33 0.4982 0.9978 3187871 BCB03_000501 OCCNC(=O)C1=C[C@H](Oc2ccccc2I)[C@@H](O)[C@@H](C1)N(Cc3ccco3)C(=O)Cc4ccccc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 J03 compound treatment 520000.0 -28700.0 -0.14 480080.0 28600.0 0.13 -0.0061 -0.0311 3071530 BCB03_000502 CCOC(=O)[C@H]1C[C@H]2O[C@]32C[C@H]1C(=O)N4CCCC4[C@@H]3O[Si](C)(C)C(C)(C)C 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 J04 compound treatment 485070.0 -63600.0 -0.32 137980.0 -313000.0 -1.47 -1.2673 -0.8402 2129008 BCB03_000503 OCCNC(=O)C1=C[C@H](Oc2ccccc2I)[C@@H](O)[C@@H](C1)NCc3ccc(F)cc3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 J05 mock treatment 621650.0 73000.0 0.36 148370.0 -303000.0 -1.43 -0.7504 -0.51 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 J06 mock treatment 614300.0 65600.0 0.33 232110.0 -219000.0 -1.03 -0.4978 -0.4599 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 J07 compound treatment 231120.0 -318000.0 -1.59 110660.0 -341000.0 -1.6 -2.255 -1.0 3071528 BCB03_000504 CCOC(=O)[C@H]1CC=C2CC1C(=O)N3CCC[C@@H]3[C@@H]2O[Si](C)(C)C(C)(C)C 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 J08 compound treatment 422000.0 -127000.0 -0.63 242150.0 -209000.0 -0.98 -1.1436 -0.9772 3187877 BCB03_000505 CC(C)C[C@@H]1NC(=O)[C@@]2(C3[C@H](Cc4ccccc4)NC2=O)C(/C=C/CC\C=C\CNC(=O)[C@@H](C)NC1=O)[C@@H]5O[C@]5(C)[C@H]3C 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 J09 compound treatment 556770.0 8080.0 0.04 465760.0 14300.0 0.07 0.0761 0.97 3071529 BCB03_000506 CCOC(=O)[C@@H]1CC2O[C@@]32C[C@@H]1C(=O)N4CCC[C@@H]4[C@H]3O[Si](C)(C)C(C)(C)C 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 J10 compound treatment 302270.0 -246000.0 -1.23 335040.0 -116000.0 -0.55 -1.2575 -0.9335 3188005 BCB03_000507 CC(C)C[C@@H]1NC(=O)C(NC(=O)[C@@]2(C3[C@H](Cc4ccccc4)NC2=O)C(/C=C/CC\C=C\CNC1=O)[C@@H]5O[C@]5(C)[C@H]3C)[C@@H](C)OCc6ccccc6 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 J11 compound treatment 535260.0 -13400.0 -0.07 326180.0 -125000.0 -0.59 -0.4641 -0.7826 3071527 BCB03_000508 CCOC(=O)[C@@H]1CC=C2CC1C(=O)N3CCC[C@@H]3[C@H]2O[Si](C)(C)C(C)(C)C 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 J12 compound treatment 401470.0 -147000.0 -0.74 335930.0 -116000.0 -0.54 -0.9042 -0.9889 3188007 BCB03_000509 CC(C)C[C@@H]1NC(=O)[C@@H](NC(=O)[C@@]2(C3[C@H](Cc4ccccc4)NC2=O)C(/C=C/CC\C=C\CNC1=O)[C@@H]5O[C@]5(C)[C@H]3C)C(C)C 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 J13 compound treatment 330980.0 -218000.0 -1.09 416160.0 -35300.0 -0.17 -0.8863 -0.8057 3071654 BCB03_000510 [O-][N+](=O)c1ccccc1S(=O)(=O)N2CCC[C@@H]2[C@H]3OCC=C3C(=C)C=C 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 J14 compound treatment 386930.0 -162000.0 -0.81 338850.0 -113000.0 -0.53 -0.9458 -0.979 3188008 BCB03_000511 C[C@H]1C2[C@H](Cc3ccccc3)NC(=O)[C@@]24C(/C=C/CC\C=C\CNC(=O)[C@@H]5CCCN5C(=O)[C@H](Cc6ccccc6)NC4=O)[C@@H]7O[C@@]71C 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 J15 compound treatment 154240.0 -394000.0 -1.97 204070.0 -247000.0 -1.16 -2.2159 -0.9684 3071597 BCB03_000512 Cc1ccc(cc1)S(=O)(=O)NC/C=C\C(=C)[C@H](O)[C@H]2CCCN2S(=O)(=O)c3ccccc3[N+](=O)[O-] 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 J16 compound treatment 352870.0 -196000.0 -0.98 308080.0 -143000.0 -0.67 -1.1684 -0.9835 3188142 BCB03_000513 C[C@@H](OCc1ccccc1)C2NC(=O)[C@@]3(C4[C@H](Cc5ccccc5)NC3=O)C(/C=C/C\C=C/CNC(=O)[C@@H](C)NC2=O)[C@@H]6O[C@]6(C)[C@H]4C 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 J17 compound treatment 336420.0 -212000.0 -1.06 214920.0 -237000.0 -1.11 -1.5364 -0.9997 3071598 BCB03_000514 Cc1ccc(cc1)S(=O)(=O)NC/C=C/C(=C)[C@H](O)[C@H]2CCCN2S(=O)(=O)c3ccccc3[N+](=O)[O-] 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 J18 compound treatment 403850.0 -145000.0 -0.72 249350.0 -202000.0 -0.95 -1.1837 -0.9909 3188271 BCB03_000515 CC(C)C[C@H]1NC(=O)CNC(=O)[C@@]2(C3[C@H](Cc4ccccc4)NC2=O)C(/C=C/C\C=C/CNC1=O)[C@@H]5O[C@]5(C)[C@H]3C 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 J19 compound treatment 154430.0 -394000.0 -1.97 135270.0 -316000.0 -1.49 -2.444 -0.9904 3188138 BCB03_000516 Cc1ccc(cc1)S(=O)(=O)N(CCC=C)CC#C[C@H]2Oc3ccccc3S(=O)(=O)N4CCC[C@@H]24 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 J20 compound treatment 409700.0 -139000.0 -0.69 283790.0 -168000.0 -0.79 -1.0485 -0.998 3188272 BCB03_000517 CC(C)C[C@H]1NC(=O)C(NC(=O)[C@@]2(C3[C@H](Cc4ccccc4)NC2=O)C(/C=C/C\C=C/CNC1=O)[C@@H]5O[C@]5(C)[C@H]3C)[C@@H](C)OCc6ccccc6 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 J21 mock treatment 535530.0 -13200.0 -0.07 498330.0 46900.0 0.22 0.1094 0.4756 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 J22 mock treatment 561470.0 12800.0 0.06 255080.0 -196000.0 -0.92 -0.608 -0.6567 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 J23 compound treatment 526880.0 -21800.0 -0.11 409600.0 -41900.0 -0.2 -0.2162 -0.9611 3071656 BCB03_000518 CN1C(=C)C2CC3C4C(C5CO[C@H]([C@H]6CCCN6S(=O)(=O)c7ccccc7[N+](=O)[O-])C5=C3CC2C1=O)C(=O)N(C)C4=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 J24 compound treatment 302620.0 -246000.0 -1.23 284520.0 -167000.0 -0.79 -1.4243 -0.9766 3188275 BCB03_000519 CC(C)C[C@H]1NC(=O)[C@H](C)NC(=O)[C@@]2(C3[C@H](Cc4ccccc4)NC2=O)C(/C=C/C\C=C/CNC1=O)[C@@H]5O[C@]5(C)[C@H]3C 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 K01 compound treatment 160190.0 -389000.0 -1.94 194290.0 -257000.0 -1.21 -2.2274 -0.9741 3071254 BCB03_000520 CC(C)[Si](O[C@@H](C#C)c1ccccc1)(C#Cc2ccccc2)C(C)C 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 K02 compound treatment 623150.0 74500.0 0.37 374940.0 -76500.0 -0.36 0.0085 0.0164 3220747 BCB03_000521 COC(=O)c1c(CC[C@@H](CO)NC(=O)N2CCCC2)oc(C(=O)Cc3ccccc3)c1C(=O)OC 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 K03 compound treatment 609640.0 60900.0 0.3 481760.0 30300.0 0.14 0.316 0.9403 3189418 BCB03_000522 CC#CCO[Si](C#Cc1ccccc1)(C(C)C)C(C)C 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 K04 compound treatment 623240.0 74500.0 0.37 564100.0 113000.0 0.53 0.6379 0.9851 3220749 BCB03_000523 COC(=O)c1c(CC[C@@H](CO)NC(=O)NCC(C)C)oc(C(=O)Cc2ccccc2)c1C(=O)OC 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 K05 compound treatment 498090.0 -50600.0 -0.25 383680.0 -67800.0 -0.32 -0.4041 -0.9934 3071256 BCB03_000524 CC(C)[Si](O[C@@H](C#C)c1ccccc1)(C#Cc2ccc(Oc3ccccc3)cc2)C(C)C 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 K06 compound treatment 572760.0 24100.0 0.12 245790.0 -206000.0 -0.97 -0.599 -0.6145 3220751 BCB03_000525 COC(=O)c1c(CC[C@@H](CO)NC(=O)Nc2ccc(OC)cc2)oc(C(=O)Cc3ccccc3)c1C(=O)OC 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 K07 mock treatment 601810.0 53100.0 0.27 585530.0 134000.0 0.63 0.6335 0.926 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 K08 mock treatment 613160.0 64500.0 0.32 516100.0 64600.0 0.3 0.4427 0.9996 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 K09 compound treatment 536320.0 -12400.0 -0.06 178520.0 -273000.0 -1.28 -0.9515 -0.7403 3071257 BCB03_000526 CC[C@@H](O[Si](C#Cc1ccc(Oc2ccccc2)cc1)(C(C)C)C(C)C)C#C 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 K10 compound treatment 562030.0 13300.0 0.07 407520.0 -43900.0 -0.21 -0.099 -0.4561 3220772 BCB03_000527 COC(=O)c1c(CC[C@@H](CO)NC(=O)NCCc2c[nH]c3ccccc23)oc(C(=O)Cc4ccccc4)c1C(=O)OC 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 K11 compound treatment 575850.0 27200.0 0.14 217020.0 -234000.0 -1.1 -0.6838 -0.6155 3189421 BCB03_000528 CC(C)[Si](Oc1ccccc1Br)(C#CCCCC#N)C(C)C 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 K12 compound treatment 581510.0 32800.0 0.16 430840.0 -20600.0 -0.1 0.0473 0.2486 3220775 BCB03_000529 COC(=O)c1c(CC[C@@H](CO)NC(=O)Nc2nc[nH]n2)oc(C(=O)Cc3ccccc3)c1C(=O)OC 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 K13 compound treatment 272600.0 -276000.0 -1.38 275270.0 -176000.0 -0.83 -1.561 -0.9703 3189422 BCB03_000530 CC[C@@H](O[Si](C#CCCCC#N)(C(C)C)C(C)C)C#C 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 K14 compound treatment 574140.0 25400.0 0.13 411620.0 -39800.0 -0.19 -0.0426 -0.1882 3220649 BCB03_000531 COC(=O)c1c(CC[C@@H](CO)NC(=O)N[C@@H](Cc2ccccc2)Cn3cc(nn3)C4(O)CCCCC4)oc(C(=O)C)c1C(=O)OC 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 K15 mock treatment 510770.0 -37900.0 -0.19 395360.0 -56100.0 -0.26 -0.3205 -0.9868 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 K16 mock treatment 603900.0 55200.0 0.28 532650.0 81200.0 0.38 0.465 0.9872 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 K17 compound treatment 581080.0 32400.0 0.16 421060.0 -30400.0 -0.14 0.0133 0.0616 3189552 BCB03_000532 CC(C)[Si](O[C@@H](c1cn(Cc2ccccc2)nn1)c3ccccc3)(C#C[Si](C(C)C)(C(C)C)C(C)C)C(C)C 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 K18 compound treatment 620800.0 72100.0 0.36 551040.0 99600.0 0.47 0.5859 0.9916 3220651 BCB03_000533 COC(=O)c1c(CC[C@@H](CO)NC(=O)N[C@@H](Cc2ccccc2)Cn3cc(nn3)c4cncn4C)oc(C(=O)C)c1C(=O)OC 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 K19 compound treatment 552700.0 4010.0 0.02 500220.0 48800.0 0.23 0.1764 0.7659 3189553 BCB03_000534 CC[C@@H](O[Si](C#C[Si](C(C)C)(C(C)C)C(C)C)(C(C)C)C(C)C)c1cn(nn1)[C@H](CO)Cc2ccccc2 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 K20 compound treatment 464710.0 -84000.0 -0.42 524840.0 73400.0 0.35 -0.0525 -0.0967 3220653 BCB03_000535 CCCCc1cn(C[C@H](Cc2ccccc2)NC(=O)N[C@H](CO)CCc3oc(C(=O)C)c(C(=O)OC)c3C(=O)OC)nn1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 K21 compound treatment 571000.0 22300.0 0.11 549610.0 98200.0 0.46 0.4053 0.8532 3189554 BCB03_000536 CC[C@@H](O[Si](C#C[Si](C(C)C)(C(C)C)C(C)C)(C(C)C)C(C)C)c1cn(Cc2cccc(Cl)c2)nn1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 K22 compound treatment 549480.0 786.0 0.0 536480.0 85000.0 0.4 0.2856 0.714 3220655 BCB03_000537 CCOC(=O)c1cn(C[C@H](Cc2ccccc2)NC(=O)N[C@H](CO)CCc3oc(C(=O)C)c(C(=O)OC)c3C(=O)OC)nn1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 K23 mock treatment 581850.0 33200.0 0.17 507680.0 56200.0 0.26 0.3041 0.9746 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 K24 mock treatment 561680.0 13000.0 0.06 236510.0 -215000.0 -1.01 -0.669 -0.6604 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 L01 compound treatment 442450.0 -106000.0 -0.53 262140.0 -189000.0 -0.89 -1.0049 -0.9694 3071655 BCB03_000538 CN1C(=O)C2CC=C(CC2C1=O)C3=CCO[C@@H]3[C@H]4CCCN4S(=O)(=O)c5ccccc5[N+](=O)[O-] 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 L02 compound treatment 474260.0 -74400.0 -0.37 332400.0 -119000.0 -0.56 -0.6588 -0.9802 3188392 BCB03_000539 C[C@H]1C2[C@H](Cc3ccccc3)NC(=O)[C@@]24C(/C=C/C\C=C/CNC(=O)[C@@H]5CCCN5C(=O)CNC4=O)[C@@H]6O[C@@]61C 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 L03 compound treatment 508160.0 -40500.0 -0.2 443070.0 -8380.0 -0.04 -0.171 -0.8292 3188141 BCB03_000540 C=CC(=C)[C@H]1Oc2ccccc2S(=O)(=O)N3CCC[C@@H]13 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 L04 compound treatment 466190.0 -82500.0 -0.41 499310.0 47900.0 0.23 -0.1322 -0.2815 3188274 BCB03_000541 CC1=C2[C@@H](CCc3ccccc3)OB(O)C[C@@H]2[C@H]4[C@@H](C1)C(=O)N(Cc5ccccc5)C4=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 L05 compound treatment 585150.0 36500.0 0.18 497280.0 45800.0 0.22 0.2812 0.9965 3071592 BCB03_000542 CN1C(=O)C2CC=C(CC2C1=O)[C@H]3Oc4ccccc4S(=O)(=O)N5CCC[C@@H]35 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 L06 compound treatment 538400.0 -10300.0 -0.05 383520.0 -67900.0 -0.32 -0.2623 -0.8105 3070931 BCB03_000543 CCCC[C@H]1OB(O)C[C@@H]2[C@H]3[C@@H](CC(=C12)C)C(=O)N(C)C3=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 L07 mock treatment 571160.0 22500.0 0.11 375130.0 -76300.0 -0.36 -0.1745 -0.464 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 L08 mock treatment 576500.0 27800.0 0.14 504740.0 53300.0 0.25 0.2754 0.9612 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 L09 compound treatment 576320.0 27600.0 0.14 494960.0 43500.0 0.2 0.2423 0.9816 3071592 BCB03_000544 CN1C(=O)C2CC=C(CC2C1=O)[C@H]3Oc4ccccc4S(=O)(=O)N5CCC[C@@H]35 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 L10 compound treatment 539730.0 -8960.0 -0.04 339560.0 -112000.0 -0.53 -0.4038 -0.7645 3070933 BCB03_000545 CCCC[C@H]1OB(O)C[C@@H]2[C@H]3[C@@H](CC(=C12)COC)C(=O)N(C)C3=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 L11 compound treatment 508650.0 -40000.0 -0.2 299250.0 -152000.0 -0.72 -0.6476 -0.8713 3071581 BCB03_000546 O=C1C2CC=C(CC2C(=O)c3ccccc13)[C@H]4Oc5ccccc5S(=O)(=O)N6CCC[C@@H]46 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 L12 compound treatment 471410.0 -77300.0 -0.39 252370.0 -199000.0 -0.94 -0.9351 -0.9232 3188523 BCB03_000547 CCCC[C@H]1OB(O)C[C@@H]2[C@H]3[C@@H](CC(=C12)COc4ccccc4)C(=O)N(C)C3=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 L13 compound treatment 461880.0 -86800.0 -0.43 324360.0 -127000.0 -0.6 -0.7293 -0.9876 3071582 BCB03_000548 O=C1c2ccccc2C(=O)c3cc(ccc13)[C@H]4Oc5ccccc5S(=O)(=O)N6CCC[C@@H]46 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 L14 compound treatment 486850.0 -61800.0 -0.31 462560.0 11100.0 0.05 -0.1815 -0.5793 3188524 BCB03_000549 CC1=C2[C@@H](CCc3ccccc3)OB(O)C[C@@H]2n4n(C1)c(=O)n(c5ccccc5)c4=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 L15 mock treatment 530880.0 -17800.0 -0.09 470880.0 19400.0 0.09 0.0017 0.0134 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 L16 mock treatment 598960.0 50300.0 0.25 258830.0 -193000.0 -0.91 -0.4631 -0.4926 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 L17 compound treatment 476890.0 -71800.0 -0.36 464930.0 13500.0 0.06 -0.2088 -0.5732 3071529 BCB03_000550 CCOC(=O)[C@@H]1CC2O[C@@]32C[C@@H]1C(=O)N4CCC[C@@H]4[C@H]3O[Si](C)(C)C(C)(C)C 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 L18 compound treatment 566100.0 17400.0 0.09 476220.0 24800.0 0.12 0.1439 0.9896 3188525 BCB03_000551 COCC1=C2[C@@H](CCc3ccccc3)OB(O)C[C@@H]2n4n(C1)c(=O)n(c5ccccc5)c4=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 L19 compound treatment 526240.0 -22500.0 -0.11 439520.0 -11900.0 -0.06 -0.119 -0.9488 3071527 BCB03_000552 CCOC(=O)[C@@H]1CC=C2CC1C(=O)N3CCC[C@@H]3[C@H]2O[Si](C)(C)C(C)(C)C 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 L20 compound treatment 449410.0 -99300.0 -0.5 232450.0 -219000.0 -1.03 -1.079 -0.9438 3188526 BCB03_000553 OB1C[C@H]2C(=C(COc3ccccc3)Cn4n2c(=O)n(c5ccccc5)c4=O)[C@@H](CCc6ccccc6)O1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 L21 compound treatment 305000.0 -244000.0 -1.22 197010.0 -254000.0 -1.2 -1.7069 -1.0 3071531 BCB03_000554 CCOC(=O)[C@@H]1[C@@H]2CN(CCC2=C[C@@H]3[C@@H](O[Si](C(C)C)(C(C)C)C(C)C)[C@@H]4CCCN4C(=O)[C@@H]13)S(=O)(=O)c5ccc(C)cc5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 L22 compound treatment 517780.0 -30900.0 -0.15 428970.0 -22500.0 -0.11 -0.1839 -0.983 3188538 BCB03_000555 CCCC[C@H]1OB(O)C[C@H]2C1=C(C)Cn3n2c(=O)n(c4ccccc4)c3=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 L23 mock treatment 548710.0 15.9 0.0 491410.0 40000.0 0.19 0.133 0.7074 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 L24 mock treatment 563840.0 15100.0 0.08 508480.0 57000.0 0.27 0.2432 0.8725 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 M01 compound treatment 533280.0 -15400.0 -0.08 556160.0 105000.0 0.49 0.2938 0.5894 3071269 BCB03_000556 CC[C@@H](O[Si](C#C[Si](C(C)C)(C(C)C)C(C)C)(C(C)C)C(C)C)c1cn(nn1)[C@H](C)c2ccccc2 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 M02 compound treatment 539470.0 -9220.0 -0.05 529290.0 77800.0 0.37 0.2263 0.6133 3220657 BCB03_000557 COC(=O)c1c(CC[C@@H](CO)NC(=O)N[C@@H](C)Cn2cc(nn2)c3ccccn3)oc(C(=O)C)c1C(=O)OC 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 M03 compound treatment 586250.0 37600.0 0.19 233360.0 -218000.0 -1.03 -0.5927 -0.5684 3189557 BCB03_000558 CCCC#C[Si](O[C@H](CC)c1cn(Cc2ccccc2)nn1)(C(C)C)C(C)C 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 M04 compound treatment 577650.0 29000.0 0.14 544960.0 93500.0 0.44 0.4133 0.8926 3220659 BCB03_000559 COC(=O)c1c(CC[C@@H](CO)NC(=O)N[C@@H](C)Cn2cc(nn2)C3(O)CCCCC3)oc(C(=O)C)c1C(=O)OC 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 M05 compound treatment 551900.0 3210.0 0.02 229120.0 -222000.0 -1.05 -0.7281 -0.6962 3071329 BCB03_000560 CCCC#C[Si](O[C@H](CC)c1cn(nn1)[C@H](CO)Cc2ccccc2)(C(C)C)C(C)C 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 M06 compound treatment 609280.0 60600.0 0.3 500600.0 49100.0 0.23 0.3774 0.9912 3220661 BCB03_000561 COC(=O)c1c(CC[C@@H](CO)NC(=O)N[C@@H](C)Cn2cc(nn2)C3(O)CCCC3)oc(C(=O)C)c1C(=O)OC 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 M07 compound treatment 602350.0 53700.0 0.27 294750.0 -157000.0 -0.74 -0.3317 -0.4229 3071331 BCB03_000562 CCCC#C[Si](O[C@H](CC)c1cn(nn1)[C@H](C)c2ccccc2)(C(C)C)C(C)C 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 M08 compound treatment 571790.0 23100.0 0.12 470170.0 18700.0 0.09 0.1438 0.9911 3220665 BCB03_000563 COC(=O)c1c(CC[C@@H](CO)NC(=O)N[C@H](Cn2cc(Cc3ccccc3)nn2)C(C)C)oc(C(=O)C)c1C(=O)OC 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 M09 mock treatment 547760.0 -934.0 0.0 426920.0 -24500.0 -0.12 -0.0849 -0.7351 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 M10 mock treatment 531120.0 -17600.0 -0.09 518520.0 67100.0 0.32 0.161 0.4917 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 M11 compound treatment 591680.0 43000.0 0.21 336850.0 -115000.0 -0.54 -0.2293 -0.3953 3071332 BCB03_000564 CCCCCCC#C[Si](O[C@@H](c1cn(Cc2ccccc2)nn1)c3ccccc3)(C(C)C)C(C)C 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 M12 compound treatment 530080.0 -18600.0 -0.09 275530.0 -176000.0 -0.83 -0.6508 -0.7816 3220667 BCB03_000565 COC(=O)c1c(CC[C@@H](CO)NC(=O)N[C@H](Cn2cc(nn2)C3(O)CCCCC3)C(C)C)oc(C(=O)C)c1C(=O)OC 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 M13 mock treatment 601450.0 52800.0 0.26 481560.0 30100.0 0.14 0.2865 0.9576 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 M14 mock treatment 586530.0 37800.0 0.19 562080.0 111000.0 0.52 0.5016 0.906 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 M15 compound treatment 552960.0 4270.0 0.02 319620.0 -132000.0 -0.62 -0.4234 -0.6824 3189692 BCB03_000566 CCCCCCC#C[Si](O[C@@H](c1cn(nn1)[C@H](CO)Cc2ccccc2)c3ccccc3)(C(C)C)C(C)C 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 M16 compound treatment 550880.0 2190.0 0.01 406470.0 -45000.0 -0.21 -0.1419 -0.6697 3220669 BCB03_000567 COC(=O)c1c(CC[C@@H](CO)NC(=O)N[C@H](Cn2cc(nn2)c3cncn3C)C(C)C)oc(C(=O)C)c1C(=O)OC 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 M17 compound treatment 546430.0 -2260.0 -0.01 512050.0 60600.0 0.29 0.1936 0.6785 3189693 BCB03_000568 CCCCCCC#C[Si](O[C@@H](c1cn(Cc2cccc(Cl)c2)nn1)c3ccccc3)(C(C)C)C(C)C 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 M18 compound treatment 524550.0 -24100.0 -0.12 501180.0 49700.0 0.23 0.0801 0.3045 3414054 BCB03_000569 COC(=O)c1c(CC[C@@H](CO)NC(=O)N2CCC[C@H]2Cn3cc(nn3)c4ccccn4)oc(C(=O)C)c1C(=O)OC 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 M19 compound treatment 406820.0 -142000.0 -0.71 496510.0 45100.0 0.21 -0.3512 -0.4748 3189694 BCB03_000570 CCCCCCC#C[Si](O[C@@H](c1cn(nn1)[C@H](C)c2ccccc2)c3ccccc3)(C(C)C)C(C)C 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 M20 compound treatment 561680.0 13000.0 0.06 240540.0 -211000.0 -0.99 -0.6556 -0.6595 3414055 BCB03_000571 COC(=O)c1c(CC[C@@H](CO)NC(=O)N2CCC[C@H]2Cn3cc(Cc4ccccc4)nn3)oc(C(=O)C)c1C(=O)OC 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 M21 compound treatment 468430.0 -80300.0 -0.4 409960.0 -41500.0 -0.2 -0.4215 -0.9453 3071395 BCB03_000572 CC(C)[Si](O[C@@H](c1cn(Cc2ccccc2)nn1)c3ccccc3)(C#CCCCC#N)C(C)C 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 M22 compound treatment 555550.0 6860.0 0.03 487360.0 35900.0 0.17 0.1436 0.8335 3414056 BCB03_000573 COC(=O)c1c(CC[C@@H](CO)NC(=O)N2CCC[C@H]2Cn3cc(nn3)C4(O)CCCCC4)oc(C(=O)C)c1C(=O)OC 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 M23 compound treatment 485480.0 -63200.0 -0.32 317060.0 -134000.0 -0.63 -0.6702 -0.9485 3189697 BCB03_000574 CC(C)[Si](O[C@@H](c1cn(nn1)[C@H](CO)Cc2ccccc2)c3ccccc3)(C#CCCCC#N)C(C)C 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 M24 compound treatment 512410.0 -36300.0 -0.18 413850.0 -37600.0 -0.18 -0.2532 -0.9999 3414057 BCB03_000575 CCCCc1cn(C[C@@H]2CCCN2C(=O)N[C@H](CO)CCc3oc(C(=O)C)c(C(=O)OC)c3C(=O)OC)nn1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 N01 compound treatment 449640.0 -99100.0 -0.49 457650.0 6200.0 0.03 -0.3292 -0.6643 3071585 BCB03_000576 OCCOCCO[C@H]1C[C@H]2C(=C[C@@H]1C(=O)[C@@]32CO3)Br 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 N02 compound treatment 582800.0 34100.0 0.17 356840.0 -94600.0 -0.45 -0.1942 -0.4076 3215882 BCB03_000577 CCCC[C@H]1OB(O)C[C@H]2C1=C(COC)Cn3n2c(=O)n(c4ccccc4)c3=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 N03 compound treatment 375570.0 -173000.0 -0.86 418590.0 -32900.0 -0.15 -0.7207 -0.8205 3188130 BCB03_000578 OCCCCCCO[C@H]1C[C@H]2C(=C[C@@H]1C(=O)[C@@]32CO3)Br 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 N04 compound treatment 551920.0 3230.0 0.02 454670.0 3220.0 0.02 0.0221 0.9995 3215880 BCB03_000579 CCCC[C@H]1OB(O)C[C@H]2C1=C(COc3ccccc3)Cn4n2c(=O)n(c5ccccc5)c4=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 N05 compound treatment 444320.0 -104000.0 -0.52 397780.0 -53700.0 -0.25 -0.5471 -0.9446 3071587 BCB03_000580 OCCCCO[C@H]1C[C@H]2C(=C[C@@H]1C(=O)[C@@]32CO3)Br 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 N06 compound treatment 83160.0 -466000.0 -2.33 77120.0 -374000.0 -1.76 -2.8891 -0.9906 3188542 BCB03_000581 CC1=C2[C@@H](CCc3ccccc3)OB(O)C[C@@H]2[C@H]4[C@@H](C1)C(=O)C=CC4=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 N07 compound treatment 256160.0 -293000.0 -1.46 110920.0 -341000.0 -1.6 -2.1657 -0.9989 3071588 BCB03_000582 BrC1=C[C@H]2[C@H](C[C@@H]1[C@@]3(CO3)C2=O)c4ccccc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 N08 compound treatment 376030.0 -173000.0 -0.86 243000.0 -208000.0 -0.98 -1.3031 -0.998 3071661 BCB03_000583 COCC1=C2[C@@H](CCc3ccccc3)OB(O)C[C@@H]2[C@H]4[C@@H](C1)C(=O)N(Cc5ccccc5)C4=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 N09 mock treatment 534560.0 -14100.0 -0.07 427520.0 -23900.0 -0.11 -0.1295 -0.9747 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 N10 mock treatment 552130.0 3440.0 0.02 504710.0 53300.0 0.25 0.1893 0.7538 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 N11 compound treatment 266360.0 -282000.0 -1.41 261000.0 -190000.0 -0.9 -1.6305 -0.976 3071589 BCB03_000584 Cc1cccc(c1)[C@H]2C[C@H]3C(=C[C@@H]2C(=O)[C@@]43CO4)Br 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 N12 compound treatment 156000.0 -393000.0 -1.96 111200.0 -340000.0 -1.6 -2.5185 -0.9949 3188543 BCB03_000585 COCC1=C2[C@@H](CCc3ccccc3)OB(O)C[C@@H]2[C@H]4[C@@H](C1)C(=O)C=CC4=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 N13 mock treatment 539170.0 -9520.0 -0.05 517470.0 66000.0 0.31 0.1859 0.5919 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 N14 mock treatment 510520.0 -38200.0 -0.19 492240.0 40800.0 0.19 8.0E-4 0.0031 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 N15 compound treatment 262470.0 -286000.0 -1.43 228090.0 -223000.0 -1.05 -1.7537 -0.9885 3071590 BCB03_000586 COc1ccc(cc1)[C@H]2C[C@H]3C(=C[C@@H]2C(=O)[C@@]43CO4)Br 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 N16 compound treatment 232610.0 -316000.0 -1.58 182240.0 -269000.0 -1.27 -2.0117 -0.994 3070948 BCB03_000587 OB1C[C@@H]2[C@H]3[C@@H](CC(=C2[C@@H](CCc4ccccc4)O1)COc5ccccc5)C(=O)C=CC3=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 N17 compound treatment 135360.0 -413000.0 -2.06 133280.0 -318000.0 -1.5 -2.518 -0.9875 3071591 BCB03_000588 CO[C@@]1(C=C(Br)[C@@H]2C[C@@H]1c3ccccc3)C(=O)[C@@]42CO4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 N18 compound treatment 81660.0 -467000.0 -2.33 57090.0 -394000.0 -1.85 -2.961 -0.9936 3070949 BCB03_000589 CCCC[C@H]1OB(O)C[C@@H]2[C@H]3[C@@H](CC(=C12)C)C(=O)C=CC3=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 N19 compound treatment 99410.0 -449000.0 -2.24 119270.0 -332000.0 -1.56 -2.6915 -0.9843 3188261 BCB03_000590 CO[C@@]1(C=C(Br)[C@@H]2C[C@@H]1c3cccc(C)c3)C(=O)[C@@]42CO4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 N20 compound treatment 114580.0 -434000.0 -2.17 100180.0 -351000.0 -1.65 -2.7015 -0.991 3070950 BCB03_000591 CCCC[C@H]1OB(O)C[C@@H]2[C@H]3[C@@H](CC(=C12)COC)C(=O)C=CC3=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 N21 compound treatment 244970.0 -304000.0 -1.52 154270.0 -297000.0 -1.4 -2.0611 -0.9992 3071600 BCB03_000592 COc1ccc(cc1)[C@H]2C[C@H]3C(=C[C@]2(OC)C(=O)[C@@]43CO4)Br 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 N22 compound treatment 277640.0 -271000.0 -1.35 230830.0 -221000.0 -1.04 -1.691 -0.9914 3070951 BCB03_000593 CCCC[C@H]1OB(O)C[C@@H]2[C@H]3[C@@H](CC(=C12)COc4ccccc4)C(=O)C=CC3=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 N23 compound treatment 325280.0 -223000.0 -1.12 274450.0 -177000.0 -0.83 -1.3777 -0.9896 3071601 BCB03_000594 OCCOCCO[C@H]1C[C@H]2C(=C[C@@H]1C(=O)[C@@]32CO3)I 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 N24 compound treatment 271090.0 -278000.0 -1.39 206310.0 -245000.0 -1.15 -1.7957 -0.9958 3071664 BCB03_000595 OB1C[C@@H]2[C@H]3[C@@H](CC(=C2[C@@H](CCc4ccccc4)O1)COc5ccccc5)C(=O)N(Cc6ccccc6)C3=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 O01 compound treatment 470880.0 -77800.0 -0.39 413780.0 -37700.0 -0.18 -0.4001 -0.9367 3187592 BCB03_000596 CC(C)[Si](O[C@@H](c1cn(Cc2cccc(Cl)c2)nn1)c3ccccc3)(C#CCCCC#N)C(C)C 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 O02 compound treatment 609880.0 61200.0 0.31 415720.0 -35700.0 -0.17 0.0972 0.2788 3220705 BCB03_000597 CCc1oc(CC[C@@H](CO)NC(=O)NCCn2cc(nn2)C3(O)CCCCC3)c(C(=O)OC)c1C(=O)OC 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 O03 compound treatment 516320.0 -32400.0 -0.16 183000.0 -268000.0 -1.26 -1.0072 -0.7912 3071397 BCB03_000598 CC(C)[Si](O[C@@H](c1cn(nn1)[C@H](C)c2ccccc2)c3ccccc3)(C#CCCCC#N)C(C)C 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 O04 compound treatment 629120.0 80400.0 0.4 566560.0 115000.0 0.54 0.6669 0.9892 3220708 BCB03_000599 COC(=O)c1c(CC[C@@H](CO)NC(=O)NCCn2cc(nn2)C3(O)CCCC3)oc(C(=O)C)c1C(=O)OC 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 O05 compound treatment 587600.0 38900.0 0.19 497060.0 45600.0 0.21 0.2891 0.9988 3071398 BCB03_000600 CC(C)[Si](O[C@H](C)c1cn(Cc2ccccc2)nn1)(C#C[Si](C(C)C)(C(C)C)C(C)C)C(C)C 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 O06 compound treatment 582510.0 33800.0 0.17 549000.0 97500.0 0.46 0.4439 0.9078 3220711 BCB03_000601 COC(=O)c1c(CC[C@@H](CO)NC(=O)N[C@H](Cc2ccccc2)Cn3cc(nn3)c4ccccn4)oc(C(=O)C)c1C(=O)OC 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 O07 compound treatment 588890.0 40200.0 0.2 578760.0 127000.0 0.6 0.5654 0.8952 3071399 BCB03_000602 CC(C)[Si](O[C@H](C)c1cn(nn1)[C@H](CO)Cc2ccccc2)(C#C[Si](C(C)C)(C(C)C)C(C)C)C(C)C 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 O08 compound treatment 541280.0 -7410.0 -0.04 466490.0 15000.0 0.07 0.0238 0.2985 3220713 BCB03_000603 COC(=O)c1c(CC[C@@H](CO)NC(=O)N[C@H](Cc2ccccc2)Cn3cc(nn3)c4ccccc4N)oc(C(=O)C)c1C(=O)OC 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 O09 compound treatment 556820.0 8130.0 0.04 217280.0 -234000.0 -1.1 -0.7501 -0.6806 3187596 BCB03_000604 CC(C)[Si](O[C@H](C)c1cn(Cc2cccc(Cl)c2)nn1)(C#C[Si](C(C)C)(C(C)C)C(C)C)C(C)C 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 O10 compound treatment 535680.0 -13000.0 -0.06 481830.0 30400.0 0.14 0.0551 0.3509 3220715 BCB03_000605 COC(=O)c1cn(C[C@@H](Cc2ccccc2)NC(=O)N[C@H](CO)CCc3oc(C(=O)C)c(C(=O)OC)c3C(=O)OC)nn1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 O11 mock treatment 585220.0 36500.0 0.18 557180.0 106000.0 0.5 0.4807 0.9074 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 O12 mock treatment 574240.0 25500.0 0.13 552320.0 101000.0 0.47 0.4257 0.8665 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 O13 compound treatment 538460.0 -10200.0 -0.05 429980.0 -21500.0 -0.1 -0.1076 -0.9502 3071400 BCB03_000606 CC(C)[Si](O[C@H](C)c1cn(nn1)[C@H](C)c2ccccc2)(C#C[Si](C(C)C)(C(C)C)C(C)C)C(C)C 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 O14 compound treatment 566190.0 17500.0 0.09 532720.0 81300.0 0.38 0.3321 0.8469 3220717 BCB03_000607 COC(=O)c1c(CC[C@@H](CO)NC(=O)N[C@@H](Cc2ccccc2)Cn3cc(nn3)c4ccccc4)oc(C(=O)N5CCOCC5)c1C(=O)OC 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 O15 compound treatment 570620.0 21900.0 0.11 475040.0 23600.0 0.11 0.1559 1.0 3070694 BCB03_000608 COc1ccc(cn1)c2cc3CO[Si](C(C)C)(C(C)C)c3c(Cc4ccccc4)n2 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 O16 compound treatment 559360.0 10700.0 0.05 511130.0 59700.0 0.28 0.2362 0.8265 3220739 BCB03_000609 COC(=O)c1c(CC[C@@H](CO)NC(=O)N[C@@H](Cc2ccccc2)Cn3cc(nn3)c4ccccn4)oc(C(=O)N5CCOCC5)c1C(=O)OC 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 O17 compound treatment 570760.0 22100.0 0.11 464800.0 13300.0 0.06 0.1223 0.9644 3070746 BCB03_000610 COc1c(C)cc(cc1C)c2cc3CO[Si](C(C)C)(C(C)C)c3c(Cc4ccccc4)n2 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 O18 compound treatment 580130.0 31400.0 0.16 351490.0 -100000.0 -0.47 -0.2214 -0.4467 3220741 BCB03_000611 COC(=O)c1c(CC[C@@H](CO)NC(=O)N[C@@H](Cc2ccccc2)Cn3cc(nn3)C4(O)CCCC4)oc(C(=O)N5CCOCC5)c1C(=O)OC 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 O19 compound treatment 443520.0 -105000.0 -0.53 215430.0 -236000.0 -1.11 -1.1564 -0.9416 3188534 BCB03_000612 COC(=O)[C@H](Cc1ccccc1)N2CC3=CCCC=C[C@@H]3[C@H]2[C@H](O)Cc4ccccc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 O20 compound treatment 544130.0 -4560.0 -0.02 439490.0 -12000.0 -0.06 -0.0559 -0.9209 3220743 BCB03_000613 COCc1cn(C[C@H](Cc2ccccc2)NC(=O)N[C@H](CO)CCc3oc(C(=O)N4CCOCC4)c(C(=O)OC)c3C(=O)OC)nn1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 O21 compound treatment 490080.0 -58600.0 -0.29 356860.0 -94600.0 -0.44 -0.5216 -0.9794 3188535 BCB03_000614 COC(=O)[C@H](Cc1ccccc1)N2CC(=C)[C@H](/C=C/C=C)[C@H]2[C@H](O)Cc3ccccc3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 O22 compound treatment 503810.0 -44900.0 -0.22 456800.0 5350.0 0.03 -0.1407 -0.6238 3188660 BCB03_000615 COC(=O)[C@H](Cc1ccccc1)N[C@H](/C=C/C2CC2)[C@@H](O)Cc3ccccc3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 O23 compound treatment 535870.0 -12800.0 -0.06 224860.0 -227000.0 -1.07 -0.7989 -0.7483 3188536 BCB03_000616 O=C1O[C@H](Cc2ccccc2)[C@H](/C=C/C3CC3)N(CC#C)[C@H]1Cc4ccccc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 O24 compound treatment 520800.0 -27900.0 -0.14 289120.0 -162000.0 -0.76 -0.6384 -0.8225 3188661 BCB03_000617 COC(=O)[C@H](Cc1ccccc1)N(CC#C)[C@H](/C=C/C2CC2)[C@@H](O)Cc3ccccc3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 P01 compound treatment 158170.0 -391000.0 -1.95 363230.0 -88200.0 -0.41 -1.6726 -0.8388 3071602 BCB03_000618 OCCCCCCO[C@H]1C[C@H]2C(=C[C@@H]1C(=O)[C@@]32CO3)I 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 P02 compound treatment 394210.0 -154000.0 -0.77 227250.0 -224000.0 -1.05 -1.2913 -0.9882 3071666 BCB03_000619 CCCC[C@H]1OB(O)C[C@@H]2[C@H]3[C@@H](CC(=C12)C)C(=O)N(Cc4ccccc4)C3=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 P03 compound treatment 338950.0 -210000.0 -1.05 326290.0 -125000.0 -0.59 -1.157 -0.9629 3071603 BCB03_000620 OCCCCO[C@H]1C[C@H]2C(=C[C@@H]1C(=O)[C@@]32CO3)I 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 P04 compound treatment 388500.0 -160000.0 -0.8 226830.0 -225000.0 -1.06 -1.3128 -0.9906 3071711 BCB03_000621 CCCC[C@H]1OB(O)C[C@@H]2[C@H]3[C@@H](CC(=C12)COC)C(=O)N(Cc4ccccc4)C3=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 P05 compound treatment 325760.0 -223000.0 -1.11 254090.0 -197000.0 -0.93 -1.4437 -0.9959 3071604 BCB03_000622 CCCCO[C@H]1C[C@H]2C(=C[C@@H]1C(=O)[C@@]32CO3)I 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 P06 compound treatment 464070.0 -84600.0 -0.42 372800.0 -78700.0 -0.37 -0.5605 -0.9978 3071776 BCB03_000623 CCCC[C@H]1OB(O)C[C@@H]2[C@H]3[C@@H](CC(=C12)COc4ccccc4)C(=O)N(Cc5ccccc5)C3=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 P07 compound treatment 131170.0 -418000.0 -2.09 91320.0 -360000.0 -1.69 -2.6723 -0.9947 3071651 BCB03_000624 IC1=C[C@H]2[C@H](C[C@@H]1[C@@]3(CO3)C2=O)c4ccccc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 P08 compound treatment 260920.0 -288000.0 -1.44 233510.0 -218000.0 -1.03 -1.7412 -0.9863 3188405 BCB03_000625 CN1C(=O)[C@@H]2CC(=C3[C@@H](CCc4ccccc4)OB(O)C[C@@H]3[C@@H]2C1=O)C 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 P09 compound treatment 179970.0 -369000.0 -1.84 138010.0 -313000.0 -1.47 -2.3447 -0.9939 3071652 BCB03_000626 Cc1cccc(c1)[C@H]2C[C@H]3C(=C[C@@H]2C(=O)[C@@]43CO4)I 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 P10 compound treatment 429920.0 -119000.0 -0.59 204160.0 -247000.0 -1.16 -1.242 -0.9512 3070929 BCB03_000627 COCC1=C2[C@@H](CCc3ccccc3)OB(O)C[C@@H]2[C@H]4[C@@H](C1)C(=O)N(C)C4=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 P11 mock treatment 453300.0 -95400.0 -0.48 352330.0 -99100.0 -0.47 -0.6666 -0.9999 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 P12 mock treatment 483520.0 -65200.0 -0.33 288160.0 -163000.0 -0.77 -0.7733 -0.927 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 P13 compound treatment 159550.0 -389000.0 -1.94 110290.0 -341000.0 -1.6 -2.509 -0.9955 3071653 BCB03_000628 COc1ccc(cc1)[C@H]2C[C@H]3C(=C[C@@H]2C(=O)[C@@]43CO4)I 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 P14 compound treatment 187090.0 -362000.0 -1.81 211690.0 -240000.0 -1.13 -2.0745 -0.9743 3188406 BCB03_000629 CN1C(=O)[C@@H]2CC(=C3[C@@H](CCc4ccccc4)OB(O)C[C@@H]3[C@@H]2C1=O)COc5ccccc5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 P15 compound treatment 309500.0 -239000.0 -1.19 141150.0 -310000.0 -1.46 -1.8768 -0.9951 3188268 BCB03_000630 CCCCO[C@H]1C[C@H]2C(=C[C@]1(CO)C(=O)[C@@]32CO3)Br 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 P16 compound treatment 370760.0 -178000.0 -0.89 154880.0 -297000.0 -1.39 -1.6148 -0.9763 3070998 BCB03_000631 CC1=C([C@H](O)CCc2ccccc2)[C@H](CO)[C@H]3[C@@H](C1)C(=O)N(Cc4ccccc4)C3=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 P17 compound treatment 96670.0 -452000.0 -2.26 65700.0 -386000.0 -1.81 -2.8794 -0.9941 3071714 BCB03_000632 OC[C@@]1(C=C(Br)[C@@H]2C[C@@H]1c3ccccc3)C(=O)[C@@]42CO4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 P18 compound treatment 384850.0 -164000.0 -0.82 155310.0 -296000.0 -1.39 -1.5636 -0.9679 3188793 BCB03_000633 CCCC[C@@H](O)C1=C(C)C[C@@H]2[C@H]([C@H]1CO)C(=O)N(C)C2=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 P19 compound treatment 209700.0 -339000.0 -1.69 108550.0 -343000.0 -1.61 -2.3377 -0.9997 3071715 BCB03_000634 Cc1cccc(c1)[C@H]2C[C@H]3C(=C[C@]2(CO)C(=O)[C@@]43CO4)Br 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 P20 compound treatment 384520.0 -164000.0 -0.82 232800.0 -219000.0 -1.03 -1.307 -0.9937 3071118 BCB03_000635 CCCC[C@@H](O)C1=C(COC)C[C@@H]2[C@H]([C@H]1CO)C(=O)N(C)C2=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 P21 compound treatment 226290.0 -322000.0 -1.61 182680.0 -269000.0 -1.26 -2.0325 -0.9928 3071717 BCB03_000636 COc1ccc(cc1)[C@H]2C[C@H]3C(=C[C@]2(CO)C(=O)[C@@]43CO4)Br 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 P22 compound treatment 441920.0 -107000.0 -0.53 217600.0 -234000.0 -1.1 -1.1549 -0.9448 3071120 BCB03_000637 CCCC[C@@H](O)C1=C(COc2ccccc2)C[C@@H]3[C@H]([C@H]1CO)C(=O)N(C)C3=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 P23 compound treatment 245310.0 -303000.0 -1.52 120010.0 -331000.0 -1.56 -2.1738 -0.9999 3071720 BCB03_000638 BrC1=C[C@]23COC[C@H]3C[C@@H]1[C@@]4(CO4)C2=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2282 P24 compound treatment 466100.0 -82600.0 -0.41 221520.0 -230000.0 -1.08 -1.0564 -0.9127 3188808 BCB03_000639 CC1=C([C@H](O)CCc2ccccc2)[C@H](CO)n3n(C1)c(=O)n(c4ccccc4)c3=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 A01 compound treatment 489390.0 63600.0 0.32 173300.0 -237000.0 -1.11 -0.5627 -0.486 3188923 BCB03_000640 COCC1=C([C@H](O)CCc2ccccc2)[C@H](CO)n3n(C1)c(=O)n(c4ccccc4)c3=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 A02 compound treatment 516370.0 90600.0 0.45 203840.0 -206000.0 -0.97 -0.3658 -0.3419 3563114 BCB03_000641 COC(=O)C1=CN(Cc2ccc(OC)cc2)C(C)c3ccccc3C=C1C(=O)OC 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 A03 compound treatment 429030.0 3220.0 0.02 461300.0 51300.0 0.24 0.1821 0.7526 3071127 BCB03_000642 OC[C@H]1C(=C(COc2ccccc2)Cn3n1c(=O)n(c4ccccc4)c3=O)[C@H](O)CCc5ccccc5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 A04 compound treatment 477000.0 51200.0 0.26 476710.0 66700.0 0.31 0.4027 0.9948 3563115 BCB03_000643 CCOC(=O)C1=C2C(ON1)N(Cc3ccc(OC)cc3)C(C)c4ccccc24 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 A05 compound treatment 182320.0 -243000.0 -1.22 493970.0 84000.0 0.4 -0.5806 -0.4541 3071425 BCB03_000644 CCCC[C@@H](O)C1=C(C)Cn2n([C@H]1CO)c(=O)n(c3ccccc3)c2=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 A06 compound treatment 157600.0 -268000.0 -1.34 162510.0 -247000.0 -1.16 -1.7703 -0.9976 3563116 BCB03_000645 COc1ccc(CN/2C(C)c3ccccc3C\C2=N\P(=O)(Oc4ccccc4)Oc5ccccc5)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 A07 compound treatment 186040.0 -240000.0 -1.2 444070.0 34100.0 0.16 -0.7334 -0.607 3215868 BCB03_000646 CCCC[C@@H](O)C1=C(COC)Cn2n([C@H]1CO)c(=O)n(c3ccccc3)c2=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 A08 compound treatment 162440.0 -263000.0 -1.32 179620.0 -230000.0 -1.08 -1.6963 -0.9954 3563118 BCB03_000647 COc1ccc(CN2CCc3ccccc3C2C)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 A09 compound treatment 449940.0 24100.0 0.12 195600.0 -214000.0 -1.01 -0.6278 -0.6182 3215866 BCB03_000648 CCCC[C@@H](O)C1=C(COc2ccccc2)Cn3n([C@H]1CO)c(=O)n(c4ccccc4)c3=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 A10 compound treatment 227560.0 -198000.0 -0.99 149930.0 -260000.0 -1.22 -1.5651 -0.9945 3563119 BCB03_000649 COC(=O)C1=CN(Cc2ccc(OC)cc2)C(C=C)c3ccccc3C=C1C(=O)OC 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 A11 compound treatment 445690.0 19900.0 0.1 159950.0 -250000.0 -1.18 -0.7614 -0.6451 3070999 BCB03_000650 COCC1=C([C@H](O)CCc2ccccc2)[C@H](CO)[C@H]3[C@@H](C1)C(=O)N(Cc4ccccc4)C3=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 A12 compound treatment 294590.0 -131000.0 -0.66 155950.0 -254000.0 -1.19 -1.3083 -0.96 3563120 BCB03_000651 CCOC(=O)C1=C2C(ON1)N(Cc3ccc(OC)cc3)C(C=C)c4ccccc24 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 A13 mock treatment 203610.0 -222000.0 -1.11 167410.0 -243000.0 -1.14 -1.5915 -0.9999 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 A14 mock treatment 225890.0 -200000.0 -1.0 209530.0 -200000.0 -0.94 -1.3727 -0.9996 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 A15 compound treatment 179900.0 -246000.0 -1.23 310170.0 -99800.0 -0.47 -1.2004 -0.913 3071000 BCB03_000652 OC[C@@H]1[C@H]2[C@@H](CC(=C1[C@H](O)CCc3ccccc3)COc4ccccc4)C(=O)N(Cc5ccccc5)C2=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 A16 compound treatment 240040.0 -186000.0 -0.93 164480.0 -246000.0 -1.15 -1.4726 -0.9941 3563121 BCB03_000653 COc1ccc(CN/2C(C=C)c3ccccc3C\C2=N\P(=O)(Oc4ccccc4)Oc5ccccc5)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 A17 compound treatment 401520.0 -24300.0 -0.12 226560.0 -183000.0 -0.86 -0.6958 -0.7987 3188676 BCB03_000654 CCCC[C@@H](O)C1=C(C)C[C@@H]2[C@H]([C@H]1CO)C(=O)N(Cc3ccccc3)C2=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 A18 compound treatment 389000.0 -36800.0 -0.18 441340.0 31400.0 0.15 -0.0257 -0.1091 3563123 BCB03_000655 COc1ccc(CN2CCc3ccccc3C2C=C)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 A19 compound treatment 382610.0 -43200.0 -0.22 475200.0 65200.0 0.31 0.0643 0.1716 3188677 BCB03_000656 CCCC[C@@H](O)C1=C(COC)C[C@@H]2[C@H]([C@H]1CO)C(=O)N(Cc3ccccc3)C2=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 A20 compound treatment 249850.0 -176000.0 -0.88 290910.0 -119000.0 -0.56 -1.0175 -0.9763 3563124 BCB03_000657 COC(=O)C1=CN(Cc2ccc(OC)cc2)C(C3CC3)c4ccccc4C=C1C(=O)OC 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 A21 compound treatment 432700.0 6890.0 0.03 206030.0 -204000.0 -0.96 -0.654 -0.6813 3188788 BCB03_000658 CCCC[C@@H](O)C1=C(COc2ccccc2)C[C@@H]3[C@H]([C@H]1CO)C(=O)N(Cc4ccccc4)C3=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 A22 compound treatment 353790.0 -72000.0 -0.36 382770.0 -27200.0 -0.13 -0.3449 -0.9033 3563125 BCB03_000659 CCOC(=O)C1=C2C(ON1)N(Cc3ccc(OC)cc3)C(C4CC4)c5ccccc25 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 A23 compound treatment 430880.0 5070.0 0.03 315160.0 -94800.0 -0.45 -0.2975 -0.6659 3071005 BCB03_000660 CN1C(=O)[C@@H]2CC(=C([C@H](O)CCc3ccccc3)[C@H](CO)[C@@H]2C1=O)C 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 A24 compound treatment 476380.0 50600.0 0.25 331240.0 -78700.0 -0.37 -0.0833 -0.1858 3563121 BCB03_000661 COc1ccc(CN/2C(C=C)c3ccccc3C\C2=N\P(=O)(Oc4ccccc4)Oc5ccccc5)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 B01 compound treatment 520840.0 95000.0 0.47 477000.0 67000.0 0.32 0.5585 0.9802 3216005 BCB03_000662 CN1C(=O)[C@@H]2C[C@]/3(C)OC[C@H]([C@@H]2C1=O)\C3=C/c4ccccc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 B02 compound treatment 494720.0 68900.0 0.34 483570.0 73600.0 0.35 0.4881 1.0 3614372 BCB03_000663 CCCNc1ncnc2ccccc12 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 B03 compound treatment 416160.0 -9650.0 -0.05 390720.0 -19300.0 -0.09 -0.0981 -0.9563 3216013 BCB03_000664 CN1C(=O)[C@@H]2C[C@]/3(COc4ccccc4)OC[C@H]([C@@H]2C1=O)\C3=C/c5ccccc5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 B04 compound treatment 458280.0 32500.0 0.16 459840.0 49900.0 0.23 0.2805 0.9838 3614373 BCB03_000665 CC(C)(C)OC(=O)NCCOCCOCCNc1ncnc2ccccc12 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 B05 compound treatment 448500.0 22700.0 0.11 521200.0 111000.0 0.52 0.45 0.8408 3614374 BCB03_000666 C[C@]1(C[C@@H]2[C@H]([C@H]/3CO1)C(=O)N(Cc4ccccc4)C2=O)\C3=C\c5cccc(COC(=O)NCc6cccc(Cl)c6)c5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 B06 compound treatment 367040.0 -58800.0 -0.29 414720.0 4740.0 0.02 -0.1918 -0.6516 3614376 BCB03_000667 CC(C)(C)OC(=O)NCCOCCOCCNC(=O)c1ccc(NC(=S)Nc2ccc(Nc3ccccc3)cc2)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 B07 compound treatment 298500.0 -127000.0 -0.64 424550.0 14600.0 0.07 -0.4012 -0.6273 3614378 BCB03_000668 C[C@]1(C[C@@H]2[C@H]([C@H]/3CO1)C(=O)N(Cc4ccccc4)C2=O)\C3=C\c5cccc(COC(=O)NCC#C)c5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 B08 compound treatment 459330.0 33500.0 0.17 458410.0 48400.0 0.23 0.2795 0.9885 3614380 BCB03_000669 Oc1ccc2ncnc(NCc3ccccc3)c2c1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 B09 compound treatment 504570.0 78800.0 0.39 514090.0 104000.0 0.49 0.6244 0.9941 3614381 BCB03_000670 COC(=O)c1c(C(=O)OC)c2oc1CC[C@H](CO)NC(=O)N[C@H](Cc3ccccc3)c4cn(C[C@@H](Cc5ccccc5)NC(=O)c6oc(CC[C@H](CO)NC(=O)N[C@H](Cc7ccccc7)c8cn(C[C@@H](Cc9ccccc9)NC2=O)nn8)c(C(=O)OC)c6C(=O)OC)nn4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 B10 compound treatment 156640.0 -269000.0 -1.34 151680.0 -258000.0 -1.21 -1.8097 -0.9987 3614383 BCB03_000671 ONC(=O)/C=C/c1ccc(OCCc2cccs2)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 B11 compound treatment 456510.0 30700.0 0.15 409300.0 -684.0 0.0 0.1062 0.6921 3614385 BCB03_000672 COC(=O)c1c(C(=O)OC)c2oc1CC[C@H](CO)NC(=O)N[C@@H](Cc3ccccc3)c4cn(C[C@@H](Cc5ccccc5)NC(=O)c6oc(CC[C@H](CO)NC(=O)N[C@@H](Cc7ccccc7)c8cn(C[C@@H](Cc9ccccc9)NC2=O)nn8)c(C(=O)OC)c6C(=O)OC)nn4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 B12 compound treatment 133500.0 -292000.0 -1.46 197090.0 -213000.0 -1.0 -1.7404 -0.9831 3614386 BCB03_000673 ONC(=O)/C=C/c1ccc(OCc2ccc-3c(Cc4ccccc43)c2)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 B13 mock treatment 530580.0 105000.0 0.52 513760.0 104000.0 0.49 0.7152 0.9994 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 B14 mock treatment 495840.0 70000.0 0.35 536680.0 127000.0 0.6 0.6687 0.9678 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 B15 compound treatment 412490.0 -13300.0 -0.07 267400.0 -143000.0 -0.67 -0.5213 -0.7734 3614388 BCB03_000674 COC(=O)c1c(C(=O)OC)c2oc1CC[C@@H](CO)NC(=O)N[C@H](Cc3ccccc3)c4cn(C[C@H](Cc5ccccc5)NC(=O)c6oc(CC[C@@H](CO)NC(=O)N[C@H](Cc7ccccc7)c8cn(C[C@H](Cc9ccccc9)NC2=O)nn8)c(C(=O)OC)c6C(=O)OC)nn4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 B16 compound treatment 140550.0 -285000.0 -1.42 167870.0 -242000.0 -1.14 -1.8127 -0.9938 3614389 BCB03_000675 ONC(=O)/C=C/c1ccc(OCc2ccccc2)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 B17 compound treatment 470880.0 45100.0 0.23 486100.0 76100.0 0.36 0.4123 0.975 3614391 BCB03_000676 COC(=O)c1c(C(=O)OC)c2oc1CC[C@@H](CO)NC(=O)N[C@@H](Cc3ccccc3)c4cn(C[C@H](Cc5ccccc5)NC(=O)c6oc(CC[C@@H](CO)NC(=O)N[C@@H](Cc7ccccc7)c8cn(C[C@H](Cc9ccccc9)NC2=O)nn8)c(C(=O)OC)c6C(=O)OC)nn4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 B18 compound treatment 146920.0 -279000.0 -1.39 139630.0 -270000.0 -1.27 -1.8841 -0.999 3614392 BCB03_000677 ONC(=O)/C=C/c1ccc(OCc2ccc(Cl)cc2)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 B19 compound treatment 485200.0 59400.0 0.3 396960.0 -13000.0 -0.06 0.1664 0.5495 3556401 BCB03_000678 COC(=O)c1c(C(=O)OC)c2oc1CC[C@H](CO)NC(=O)N[C@H](Cc3ccccc3)c4cn(C[C@@H](Cc5ccccc5)NC2=O)nn4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 B20 compound treatment 104600.0 -321000.0 -1.6 84640.0 -325000.0 -1.53 -2.2165 -0.9997 3614394 BCB03_000679 Nc1cccc(COc2ccc(/C=C/C(=O)NO)cc2)c1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 B21 compound treatment 366960.0 -58800.0 -0.29 146790.0 -263000.0 -1.24 -1.0832 -0.8513 3556405 BCB03_000680 COC(=O)c1c(C(=O)OC)c2oc1CC[C@H](CO)NC(=O)N[C@H](Cc3ccccc3)c4cn(C[C@H](Cc5ccccc5)NC2=O)nn4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 B22 compound treatment 133930.0 -292000.0 -1.46 150040.0 -260000.0 -1.22 -1.8954 -0.9962 3614396 BCB03_000681 ONC(=O)/C=C/c1ccc(OCCCc2ccccc2)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 B23 compound treatment 441440.0 15600.0 0.08 356920.0 -53100.0 -0.25 -0.1213 -0.4638 3556409 BCB03_000682 COC(=O)c1c(C(=O)OC)c2oc1CC[C@H](CO)NC(=O)N[C@@H](Cc3ccccc3)c4cn(C[C@@H](Cc5ccccc5)NC2=O)nn4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 B24 compound treatment 153440.0 -272000.0 -1.36 150670.0 -259000.0 -1.22 -1.8244 -0.9985 3614398 BCB03_000683 ONC(=O)/C=C/c1ccc(OCCCCc2ccccc2)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 C01 compound treatment 467430.0 41600.0 0.21 418150.0 8170.0 0.04 0.1742 0.8238 3188790 BCB03_000684 COCC1=C([C@H](O)CCc2ccccc2)[C@H](CO)[C@H]3[C@@H](C1)C(=O)N(C)C3=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 C02 compound treatment 357470.0 -68300.0 -0.34 443880.0 33900.0 0.16 -0.1286 -0.3414 3563126 BCB03_000685 COC(=O)C1=CN(Cc2ccc(OC)cc2)C(C)C=C(C)C=C1C(=O)OC 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 C03 compound treatment 444530.0 18700.0 0.09 336730.0 -73300.0 -0.34 -0.1775 -0.4972 3188791 BCB03_000686 CN1C(=O)[C@@H]2CC(=C([C@H](O)CCc3ccccc3)[C@H](CO)[C@@H]2C1=O)COc4ccccc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 C04 compound treatment 475270.0 49500.0 0.25 464430.0 54400.0 0.26 0.3558 0.9998 3563127 BCB03_000687 COc1ccc(CN/2C(C)C=C(C)C\C2=N\P(=O)(Oc3ccccc3)Oc4ccccc4)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 C05 compound treatment 271750.0 -154000.0 -0.77 451200.0 41200.0 0.19 -0.407 -0.5129 3071437 BCB03_000688 OB1OC(CCc2ccccc2)CC=C1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 C06 compound treatment 462360.0 36600.0 0.18 474560.0 64600.0 0.3 0.3439 0.9703 3563129 BCB03_000689 COc1ccc(CN2C(C)C3C4C(C2C=C3C)C(=O)N(C)C4=O)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 C07 compound treatment 236600.0 -189000.0 -0.95 442210.0 32200.0 0.15 -0.561 -0.5862 3071483 BCB03_000690 COC(=O)c1ccc(OC)c(/C=C\CC(OC(=O)c2ccncc2)c3ccccc3)c1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 C08 compound treatment 446990.0 21200.0 0.11 408280.0 -1700.0 -0.01 0.0691 0.6517 3563130 BCB03_000691 COc1ccc(CN2CCC(=CC2C)C)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 C09 compound treatment 487330.0 61500.0 0.31 476590.0 66600.0 0.31 0.4388 1.0 3071486 BCB03_000692 CC(=O)OC(C/C=C\B1OC(C)(C)C(C)(C)O1)c2ccccc2 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 C10 compound treatment 316900.0 -109000.0 -0.54 215710.0 -194000.0 -0.91 -1.0308 -0.9693 3563131 BCB03_000693 COC(=O)C1=CN(Cc2ccc(OC)cc2)C(C=C)C=C(C)C=C1C(=O)OC 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 C11 mock treatment 314630.0 -111000.0 -0.56 176230.0 -234000.0 -1.1 -1.1701 -0.9499 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 C12 mock treatment 408040.0 -17800.0 -0.09 209440.0 -201000.0 -0.94 -0.7298 -0.7702 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 C13 compound treatment 24860.0 -401000.0 -2.0 32720.0 -377000.0 -1.77 -2.6708 -0.9982 3188011 BCB03_000694 O=C1C=C(C(=O)c2ccc(cc12)[C@H]3Oc4ccccc4S(=O)(=O)N5CCC[C@@H]35)c6ccccc6 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 C14 compound treatment 379530.0 -46300.0 -0.23 193010.0 -217000.0 -1.02 -0.8851 -0.8458 3563132 BCB03_000695 COc1ccc(CN/2C(C=C)C=C(C)C\C2=N\P(=O)(Oc3ccccc3)Oc4ccccc4)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 C15 mock treatment 296650.0 -129000.0 -0.65 445360.0 35400.0 0.17 -0.3385 -0.5081 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 C16 mock treatment 435300.0 9490.0 0.05 410900.0 916.0 0.0 0.0366 0.7682 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 C17 compound treatment 73190.0 -353000.0 -1.76 78720.0 -331000.0 -1.56 -2.3471 -0.9981 3071579 BCB03_000696 O=C1C=C(C(=O)C2=C1CC(=CC2)[C@H]3Oc4ccccc4S(=O)(=O)N5CCC[C@@H]35)c6ccccc6 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 C18 compound treatment 248660.0 -177000.0 -0.88 176040.0 -234000.0 -1.1 -1.4037 -0.9942 3563134 BCB03_000697 COc1ccc(CN2C(C=C)C3C4C(C2C=C3C)C(=O)N(C)C4=O)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 C19 compound treatment 174930.0 -251000.0 -1.25 122520.0 -287000.0 -1.35 -1.8421 -0.9993 3070932 BCB03_000698 OCC(NC(=O)OCC1c2ccccc2-c3ccccc13)C=C 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 C20 compound treatment 233980.0 -192000.0 -0.96 311540.0 -98400.0 -0.46 -1.0049 -0.9443 3563135 BCB03_000699 COc1ccc(CN2CCC(=CC2C=C)C)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 C21 compound treatment 244130.0 -182000.0 -0.91 242270.0 -168000.0 -0.79 -1.1994 -0.9976 3188522 BCB03_000700 COc1ccc(CN([C@H](COC(=O)OC(C)(C)C)C=C)S(=O)(=O)c2ccc(Br)cc2)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 C22 compound treatment 430080.0 4270.0 0.02 270280.0 -140000.0 -0.66 -0.4496 -0.6838 1025568 BCB03_000701 COc1cc2CCN(C)C(C)c2cc1OC 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 C23 compound treatment 251680.0 -174000.0 -0.87 384280.0 -25700.0 -0.12 -0.7005 -0.7977 3070934 BCB03_000702 CC(=O)OCC(NS(=O)(=O)c1ccc(Br)cc1)C=C 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 C24 compound treatment 231230.0 -195000.0 -0.97 211200.0 -199000.0 -0.94 -1.3483 -0.9998 3563136 BCB03_000703 COc1cc2CCN(C)C(C=C)c2cc1OC 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 D01 compound treatment 522680.0 96900.0 0.48 494030.0 84000.0 0.4 0.6217 0.995 3556407 BCB03_000704 COC(=O)c1c(C(=O)OC)c2oc1CC[C@H](CO)NC(=O)N[C@@H](Cc3ccccc3)c4cn(C[C@H](Cc5ccccc5)NC2=O)nn4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 D02 compound treatment 52960.0 -373000.0 -1.86 64200.0 -346000.0 -1.63 -2.4668 -0.9977 3614403 BCB03_000705 ONC(=O)/C=C/c1ccc(OCCn2c3ccccc3c4ccccc24)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 D03 compound treatment 476210.0 50400.0 0.25 431620.0 21600.0 0.1 0.25 0.9206 3556412 BCB03_000706 COC(=O)c1c(C(=O)OC)c2oc1CC[C@@H](CO)NC(=O)N[C@@H](Cc3ccccc3)c4cn(C[C@@H](Cc5ccccc5)NC2=O)nn4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 D04 compound treatment 422050.0 -3760.0 -0.02 407090.0 -2890.0 -0.01 -0.0229 -0.9876 3614405 BCB03_000707 Cc1cccc(Cl)c1NC(=O)C2=CC=C(Cl)C2 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 D05 compound treatment 509960.0 84200.0 0.42 218510.0 -191000.0 -0.9 -0.3396 -0.3417 3614406 BCB03_000708 COC(=O)c1c(C(=O)OC)c2oc1CC[C@H](CO)NC(=O)N[C@H](Cc3ccccc3)C(=O)NCc4cn(C[C@@H](Cc5ccccc5)NC(=O)c6oc(CC[C@H](CO)NC(=O)N[C@H](Cc7ccccc7)C(=O)NCc8cn(C[C@@H](Cc9ccccc9)NC2=O)nn8)c(C(=O)OC)c6C(=O)OC)nn4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 D06 compound treatment 181150.0 -245000.0 -1.22 217140.0 -193000.0 -0.91 -1.5054 -0.9892 3614408 BCB03_000709 COc1ccc(CN(C(=O)C2=CC=C(Cl)C2)c3c(C)cccc3Cl)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 D07 compound treatment 483200.0 57400.0 0.29 492800.0 82800.0 0.39 0.4781 0.9886 3614409 BCB03_000710 COC(=O)c1c(C(=O)OC)c2oc1CC[C@H](CO)NC(=O)N[C@H](Cc3ccccc3)C(=O)NCc4cn(C[C@H](Cc5ccccc5)NC(=O)c6oc(CC[C@H](CO)NC(=O)N[C@H](Cc7ccccc7)C(=O)NCc8cn(C[C@H](Cc9ccccc9)NC2=O)nn8)c(C(=O)OC)c6C(=O)OC)nn4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 D08 compound treatment 264960.0 -161000.0 -0.8 278920.0 -131000.0 -0.62 -1.004 -0.9914 3614410 BCB03_000711 COc1ccc(CN(C(=O)C2=CC=C(C2)Nc3cc(Cl)nc(C)n3)c4c(C)cccc4Cl)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 D09 compound treatment 473490.0 47700.0 0.24 364160.0 -45800.0 -0.22 0.016 0.0498 3614411 BCB03_000712 COC(=O)c1c(C(=O)OC)c2oc1CC[C@H](CO)NC(=O)N[C@@H](Cc3ccccc3)C(=O)NCc4cn(C[C@@H](Cc5ccccc5)NC(=O)c6oc(CC[C@H](CO)NC(=O)N[C@@H](Cc7ccccc7)C(=O)NCc8cn(C[C@@H](Cc9ccccc9)NC2=O)nn8)c(C(=O)OC)c6C(=O)OC)nn4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 D10 compound treatment 269350.0 -156000.0 -0.78 259700.0 -150000.0 -0.71 -1.0524 -0.9987 3614412 BCB03_000713 Cc1cccc(Cl)c1NC(=O)C2=CC=C(C2)Nc3cc(Cl)nc(C)n3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 D11 mock treatment 492450.0 66600.0 0.33 388990.0 -21000.0 -0.1 0.1655 0.4768 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 D12 mock treatment 473150.0 47300.0 0.24 417080.0 7100.0 0.03 0.1908 0.799 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 D13 compound treatment 206400.0 -219000.0 -1.1 361510.0 -48500.0 -0.23 -0.9361 -0.8363 3614413 BCB03_000714 COC(=O)c1c(C(=O)OC)c2oc1CC[C@H](CO)NC(=O)N[C@@H](Cc3ccccc3)C(=O)NCc4cn(C[C@H](Cc5ccccc5)NC(=O)c6oc(CC[C@H](CO)NC(=O)N[C@@H](Cc7ccccc7)C(=O)NCc8cn(C[C@H](Cc9ccccc9)NC2=O)nn8)c(C(=O)OC)c6C(=O)OC)nn4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 D14 compound treatment 188030.0 -238000.0 -1.19 195440.0 -215000.0 -1.01 -1.5533 -0.9967 3614414 BCB03_000715 Cc1cccc(Cl)c1NC(=O)c2cnc(Nc3cc(nc(C)n3)N4CCN(CCO)CC4)s2 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 D15 mock treatment 414580.0 -11200.0 -0.06 186650.0 -223000.0 -1.05 -0.7825 -0.7438 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 D16 mock treatment 527370.0 102000.0 0.51 475720.0 65700.0 0.31 0.5773 0.9718 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 D17 compound treatment 410630.0 -15200.0 -0.08 484500.0 74500.0 0.35 0.1942 0.5416 3556423 BCB03_000716 COC(=O)c1c(C(=O)OC)c2oc1CC[C@H](CO)NC(=O)N[C@H](Cc3ccccc3)C(=O)NCc4cn(C[C@@H](Cc5ccccc5)NC2=O)nn4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 D18 compound treatment 263540.0 -162000.0 -0.81 201760.0 -208000.0 -0.98 -1.2656 -0.9956 3614415 BCB03_000717 COC(=O)C1(CCCC1)C2CC(=C)[C@@H](/C=C/C=C)[C@@H]2[C@@H](O)CCO 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 D19 compound treatment 409240.0 -16600.0 -0.08 208860.0 -201000.0 -0.95 -0.7274 -0.766 3556419 BCB03_000718 COC(=O)c1c(C(=O)OC)c2oc1CC[C@H](CO)NC(=O)N[C@H](Cc3ccccc3)C(=O)NCc4cn(C[C@H](Cc5ccccc5)NC2=O)nn4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 D20 compound treatment 281220.0 -145000.0 -0.72 214580.0 -195000.0 -0.92 -1.1605 -0.9929 3614418 BCB03_000719 Cn1c(=O)n2[C@H]3[C@@H]4[C@H](CCN=[N+]=[N-])OC(=O)[C@H](Cc5ccccc5)N4CC3=C[C@@H](C6CC6)n2c1=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 D21 compound treatment 272160.0 -154000.0 -0.77 170560.0 -239000.0 -1.13 -1.339 -0.9825 3614420 BCB03_000720 COC(=O)c1c(C(=O)OC)c2oc1CC[C@H](CO)NC(=O)N[C@@H](Cc3ccccc3)C(=O)NCc4cn(C[C@@H](Cc5ccccc5)NC2=O)nn4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 D22 compound treatment 344180.0 -81600.0 -0.41 173640.0 -236000.0 -1.11 -1.0744 -0.9073 3614421 BCB03_000721 [N-]=[N+]=NCC[C@@H]1OC(=O)[C@H](Cc2ccccc2)N3CC4=CCCC=C[C@H]4[C@H]13 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 D23 compound treatment 355220.0 -70600.0 -0.35 220290.0 -190000.0 -0.89 -0.8802 -0.9175 3614424 BCB03_000722 COC(=O)c1cn(CC(=O)N2CCC3(CC2)N(CNC3=O)c4ccccc4)nn1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 D24 compound treatment 12500.0 -413000.0 -2.06 10040.0 -400000.0 -1.88 -2.7899 -0.9989 3614425 BCB03_000723 [N-]=[N+]=NCC[C@@H]1OC(=O)[C@H](Cc2ccccc2)N3CC4=CC(=O)[C@H](C5CC5)[C@H]4[C@H]13 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 E01 mock treatment 392320.0 -33500.0 -0.17 522400.0 112000.0 0.53 0.2556 0.4609 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 E02 mock treatment 528770.0 103000.0 0.51 538200.0 128000.0 0.6 0.7901 0.9969 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 E03 compound treatment 482260.0 56500.0 0.28 477250.0 67300.0 0.32 0.4231 0.9983 3070935 BCB03_000724 O=C(CCCCCCC(=O)Nc1ccccc1)N/N=C/c2ccccc2 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 E04 compound treatment 479200.0 53400.0 0.27 508230.0 98200.0 0.46 0.5153 0.9659 3563137 BCB03_000725 COc1cc2CCN(C)C(C3CC3)c2cc1OC 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 E05 compound treatment 513600.0 87800.0 0.44 402660.0 -7320.0 -0.03 0.2857 0.6495 3070936 BCB03_000726 C/C(=N\O)/C(=O)NCCCCCNC(=O)OCc1ccccc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 E06 compound treatment 165120.0 -261000.0 -1.3 491260.0 81300.0 0.38 -0.6503 -0.4793 3563138 BCB03_000727 COCC#CC1N(C)CCc2cc(OC)c(OC)cc12 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 E07 compound treatment 510280.0 84500.0 0.42 500210.0 90200.0 0.42 0.5984 1.0 3070944 BCB03_000728 O/N=C(\Cc1ccccc1)/C(=O)NCCCCCNC(=O)OCc2ccccc2 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 E08 compound treatment 556290.0 130000.0 0.65 554880.0 145000.0 0.68 0.9427 0.9997 3562035 BCB03_000729 COc1ccc(C[N+]2=Cc3cc(OC)c(OC)cc3CC2)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 E09 mock treatment 528610.0 103000.0 0.51 469760.0 59800.0 0.28 0.5619 0.9598 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 E10 mock treatment 518410.0 92600.0 0.46 518670.0 109000.0 0.51 0.6885 0.9988 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 E11 compound treatment 484800.0 59000.0 0.29 198270.0 -212000.0 -1.0 -0.4958 -0.4774 3188539 BCB03_000730 C[C@@H]1ON([C@@H]([C@H]1C(=O)N2[C@H](Cc3ccccc3)COC2=O)c4ccccc4)c5ccccc5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 E12 compound treatment 177720.0 -248000.0 -1.24 156900.0 -253000.0 -1.19 -1.7179 -0.9998 3563139 BCB03_000731 COc1ccc(CN2CCc3cc(OC)c(OC)cc3C2C)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 E13 compound treatment 447680.0 21900.0 0.11 459420.0 49400.0 0.23 0.2417 0.9407 3188540 BCB03_000732 C[C@H]1ON([C@H]([C@@H]1C(=O)N2[C@H](COC2=O)c3ccccc3)c4ccccc4)c5ccccc5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 E14 compound treatment 192930.0 -233000.0 -1.16 182950.0 -227000.0 -1.07 -1.5776 -0.9991 3563140 BCB03_000733 COc1ccc(CN2CCc3cc(OC)c(OC)cc3C2C=C)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 E15 compound treatment 517030.0 91200.0 0.46 389760.0 -20200.0 -0.1 0.2549 0.5477 3188541 BCB03_000734 C[C@@H]1ON([C@@H]([C@H]1C(=O)O)c2ccccc2)c3ccccc3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 E16 compound treatment 193570.0 -232000.0 -1.16 202830.0 -207000.0 -0.97 -1.5092 -0.9962 3563141 BCB03_000735 COc1ccc(CN2CCc3cc(OC)c(OC)cc3C2C4CC4)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 E17 mock treatment 212320.0 -213000.0 -1.07 271360.0 -139000.0 -0.65 -1.215 -0.9722 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 E18 mock treatment 475680.0 49900.0 0.25 195560.0 -214000.0 -1.01 -0.537 -0.5169 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 E19 compound treatment 315720.0 -110000.0 -0.55 205350.0 -205000.0 -0.96 -1.0694 -0.9647 3070947 BCB03_000736 C[C@@H]1ON([C@@H]([C@H]1C(=O)N2[C@H](Cc3ccccc3)COC2=O)c4ccc(O)cc4)c5ccc(cc5)C(=O)OC(C)(C)C 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 E20 compound treatment 506130.0 80300.0 0.4 183810.0 -226000.0 -1.06 -0.4686 -0.4121 3563142 BCB03_000737 COCC#CC1N(Cc2ccc(OC)cc2)CCc3cc(OC)c(OC)cc13 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 E21 compound treatment 332860.0 -92900.0 -0.46 194910.0 -215000.0 -1.01 -1.0436 -0.9376 3188544 BCB03_000738 C[C@H]1ON([C@H]([C@@H]1C(=O)N2[C@H](COC2=O)c3ccccc3)c4ccc(O)cc4)c5ccc(cc5)C(=O)OC(C)(C)C 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 E22 compound treatment 462850.0 37000.0 0.19 462500.0 52500.0 0.25 0.3055 0.9899 3563143 BCB03_000739 COc1cc2CCN(C)C(C)(C)c2cc1OC 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 E23 compound treatment 424080.0 -1730.0 -0.01 454160.0 44200.0 0.21 0.1408 0.6772 3188657 BCB03_000740 C[C@@H]1ON([C@@H]([C@H]1C(=O)N2[C@H](Cc3ccccc3)COC2=O)c4ccc(Br)cc4)c5cccc(c5)C(=O)OC(C)(C)C 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 E24 compound treatment 404540.0 -21300.0 -0.11 386800.0 -23200.0 -0.11 -0.1522 -0.9999 3563144 BCB03_000741 COc1cc2CCN(C)C(C)(C=C)c2cc1OC 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 F01 mock treatment 566530.0 141000.0 0.7 539680.0 130000.0 0.61 0.9283 0.9975 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 F02 mock treatment 562280.0 136000.0 0.68 540030.0 130000.0 0.61 0.9145 0.9985 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 F03 compound treatment 228290.0 -198000.0 -0.99 493920.0 83900.0 0.39 -0.4184 -0.3938 3614432 BCB03_000742 COC(=O)c1cn(C[C@@H](Cc2ccccc2)NC(=O)Nc3ccccc3)nn1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 F04 compound treatment 352250.0 -73600.0 -0.37 476720.0 66700.0 0.31 -0.0378 -0.0783 3614434 BCB03_000743 COC(=O)[C@H](Cc1ccccc1)N[C@H](/C=C/C2CC2)[C@@H](O)CCN=[N+]=[N-] 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 F05 compound treatment 329440.0 -96400.0 -0.48 527610.0 118000.0 0.55 0.0509 0.0694 3614437 BCB03_000744 COC(=O)c1cn(C[C@H](Cc2ccccc2)NC(=O)c3ccccc3)nn1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 F06 compound treatment 208050.0 -218000.0 -1.09 218620.0 -191000.0 -0.9 -1.4055 -0.9956 3614440 BCB03_000745 [N-]=[N+]=NCC[C@@H]1OC(=O)[C@H](Cc2ccccc2)N(CC#C)[C@@H]1/C=C/C3CC3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 F07 compound treatment 202050.0 -224000.0 -1.12 348910.0 -61100.0 -0.29 -0.9934 -0.8609 3614442 BCB03_000746 COC(=O)c1cn(CCCNC(=S)Nc2ccc(cc2)[N+](=O)[O-])nn1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 F08 compound treatment 530520.0 105000.0 0.52 454400.0 44400.0 0.21 0.5175 0.919 3614443 BCB03_000747 C=C/C=C/[C@H]1[C@@H]2[C@H](CCN=[N+]=[N-])OC(=O)[C@H](Cc3ccccc3)N2CC1=C 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 F09 mock treatment 497140.0 71300.0 0.36 229280.0 -181000.0 -0.85 -0.3491 -0.3788 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 F10 mock treatment 406460.0 -19300.0 -0.1 539680.0 130000.0 0.61 0.363 0.5878 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 F11 compound treatment 407570.0 -18200.0 -0.09 403520.0 -6460.0 -0.03 -0.0859 -0.8946 3614446 BCB03_000748 COC(=O)c1cn(CCCNC(=O)Nc2ccccc2)nn1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 F12 compound treatment 455380.0 29600.0 0.15 251080.0 -159000.0 -0.75 -0.4241 -0.5566 3614447 BCB03_000749 COC(=O)[C@H](Cc1ccccc1)N2C[C@](C)(OC(C)C)O[C@@H](CCN=[N+]=[N-])[C@H]2/C=C/C3CC3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 F13 compound treatment 433650.0 7840.0 0.04 199630.0 -210000.0 -0.99 -0.6719 -0.6786 3614451 BCB03_000750 COC(=O)c1cn(CCNC(=O)Nc2ccccc2)nn1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 F14 compound treatment 476640.0 50800.0 0.25 187920.0 -222000.0 -1.04 -0.5591 -0.5201 3614452 BCB03_000751 COC(=O)C1(CCCC1)C2CC3=C[C@@H](C4CC4)n5n([C@H]3[C@@H]2[C@@H](O)CCO)c(=O)n(C)c5=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 F15 compound treatment 444680.0 18900.0 0.09 146820.0 -263000.0 -1.24 -0.8086 -0.6514 3614455 BCB03_000752 COC(=O)c1cn(CCCNC(=O)[C@H](Cc2ccccc2)NS(=O)(=O)c3ccc(C)cc3)nn1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 F16 compound treatment 157400.0 -268000.0 -1.34 151250.0 -259000.0 -1.22 -1.8085 -0.9988 3614458 BCB03_000753 OCC[C@@H]1OC(=O)C2(CCCC2)N3CC4=CC(=O)[C@H](C5CC5)[C@H]4[C@H]13 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 F17 mock treatment 251210.0 -175000.0 -0.87 456170.0 46200.0 0.22 -0.463 -0.5152 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 F18 mock treatment 517990.0 92200.0 0.46 498680.0 88700.0 0.42 0.6206 0.9988 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 F19 compound treatment 459910.0 34100.0 0.17 167240.0 -243000.0 -1.14 -0.6869 -0.595 3614462 BCB03_000754 COC(=O)c1cn(CCNC(=O)[C@H](Cc2ccccc2)NS(=O)(=O)c3ccc(C)cc3)nn1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 F20 compound treatment 456640.0 30800.0 0.15 225680.0 -184000.0 -0.87 -0.5041 -0.5725 3563105 BCB03_000755 COC(=O)C1=CN(C)C(C=C)c2ccccc2C=C1C(=O)OC 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 F21 compound treatment 224290.0 -202000.0 -1.01 241350.0 -169000.0 -0.79 -1.2726 -0.9931 3614464 BCB03_000756 COC(=O)c1cn(CCNC(=O)[C@@H](NS(=O)(=O)c2ccc(C)cc2)C(C)C)nn1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 F22 compound treatment 339300.0 -86500.0 -0.43 262410.0 -148000.0 -0.69 -0.7963 -0.974 3563108 BCB03_000757 COC(=O)C1=CN(C)C(C2CC2)c3ccccc3C=C1C(=O)OC 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 F23 compound treatment 399040.0 -26800.0 -0.13 421920.0 11900.0 0.06 -0.0548 -0.3782 3614467 BCB03_000758 COC(=O)c1cn(C[C@@H]2CCCN2S(=O)(=O)c3ccc(C)cc3)nn1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 F24 compound treatment 459280.0 33500.0 0.17 466720.0 56700.0 0.27 0.3069 0.9746 3188926 BCB03_000759 CC(C)CCC[C@@H](C)[C@H]1CC[C@@]2(C)C3=C(CC[C@]12C)[C@@]4(C)CC[C@H](OC(=O)c5ccc(nc5)C(F)(F)F)C(C)(C)C4CC3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 G01 compound treatment 598210.0 172000.0 0.86 594330.0 184000.0 0.87 1.222 1.0 3188658 BCB03_000760 C[C@@H]1ON([C@@H]([C@H]1C(=O)N2[C@H](Cc3ccccc3)COC2=O)c4ccc(Br)cc4)c5ccc(cc5)C(=O)OC(C)(C)C 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 G02 compound treatment 542430.0 117000.0 0.58 534800.0 125000.0 0.59 0.827 1.0 3563145 BCB03_000761 COCC#CC1(C)N(C)CCc2cc(OC)c(OC)cc21 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 G03 mock treatment 577760.0 152000.0 0.76 589380.0 179000.0 0.84 1.1333 0.9986 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 G04 mock treatment 216860.0 -209000.0 -1.04 493130.0 83100.0 0.39 -0.4614 -0.414 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 G05 compound treatment 543310.0 118000.0 0.59 215230.0 -195000.0 -0.92 -0.2328 -0.214 3188659 BCB03_000762 C[C@@H]1ON([C@@H]([C@H]1C(=O)N2[C@H](Cc3ccccc3)COC2=O)c4cccc(NC(=O)OCC5c6ccccc6-c7ccccc57)c4)c8ccc(I)cc8 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 G06 compound treatment 484830.0 59000.0 0.29 471450.0 61500.0 0.29 0.4129 1.0 3563146 BCB03_000763 COc1ccc(C[N+]2=C(C)c3cc(OC)c(OC)cc3CC2)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 G07 compound treatment 331740.0 -94100.0 -0.47 170130.0 -240000.0 -1.13 -1.13 -0.9246 3188672 BCB03_000764 C[C@@H]1ON([C@@H]([C@H]1C(=O)N2[C@H](Cc3ccccc3)COC2=O)c4ccc(OC(=O)OC(C)(C)C)cc4)c5ccc(I)cc5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 G08 compound treatment 550480.0 125000.0 0.62 459960.0 50000.0 0.24 0.6065 0.9113 3563147 BCB03_000765 COc1ccc(CN2CCc3cc(OC)c(OC)cc3C2(C)C)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 G09 compound treatment 506080.0 80300.0 0.4 478720.0 68700.0 0.32 0.5121 0.9943 3188673 BCB03_000766 COC(=O)CCCCCCC(=O)Nc1ccc(NC(=O)CCCC[P+](c2ccccc2)(c3ccccc3)c4ccccc4)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 G10 compound treatment 355040.0 -70800.0 -0.35 438000.0 28000.0 0.13 -0.1567 -0.4155 3563148 BCB03_000767 COc1ccc(CN2CCc3cc(OC)c(OC)cc3C2(C)C=C)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 G11 compound treatment 186760.0 -239000.0 -1.19 162010.0 -248000.0 -1.17 -1.669 -0.9999 3188674 BCB03_000768 CC(C)[C@H]1COC(=O)N1C(=O)[C@@H]2[C@@H](C)ON([C@@H]2c3ccccc3)c4ccccc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 G12 compound treatment 156640.0 -269000.0 -1.34 134970.0 -275000.0 -1.29 -1.8653 -0.9998 3563149 BCB03_000769 COc1ccc(CN2CCc3cc(OC)c(OC)cc3C2(C)C4CC4)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 G13 compound treatment 158630.0 -267000.0 -1.33 133140.0 -277000.0 -1.3 -1.8644 -0.9999 3188675 BCB03_000770 CC(C)[C@@H](CO)NC(=O)[C@@H]1[C@@H](C)ON([C@@H]1c2ccccc2)c3ccccc3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 G14 compound treatment 463230.0 37400.0 0.19 306500.0 -103000.0 -0.49 -0.212 -0.4066 3563150 BCB03_000771 COCC#CC1(C)N(Cc2ccc(OC)cc2)CCc3cc(OC)c(OC)cc31 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 G15 compound treatment 498660.0 72900.0 0.36 199950.0 -210000.0 -0.99 -0.4413 -0.4191 3071001 BCB03_000772 COC(=O)[C@@H]1N[C@H]2[C@@H](COc3ccccc23)[C@@H]1C(=O)OC 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 G16 compound treatment 507120.0 81300.0 0.41 486990.0 77000.0 0.36 0.5433 0.9984 3563151 BCB03_000773 COc1cc2CC(C)N(C)C(C)c2cc1OC 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 G17 compound treatment 489840.0 64000.0 0.32 413310.0 3330.0 0.02 0.2372 0.7408 3071002 BCB03_000774 OCC1CC(=NO1)c2ccccc2 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 G18 compound treatment 388930.0 -36900.0 -0.18 476320.0 66300.0 0.31 0.0904 0.2495 3563152 BCB03_000775 COc1cc2CC(C)N(C)C(C=C)c2cc1OC 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 G19 mock treatment 392440.0 -33400.0 -0.17 348050.0 -61900.0 -0.29 -0.3238 -0.9649 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 G20 mock treatment 443250.0 17400.0 0.09 312040.0 -97900.0 -0.46 -0.2642 -0.5634 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 G21 compound treatment 432070.0 6260.0 0.03 290830.0 -119000.0 -0.56 -0.3742 -0.6666 3071004 BCB03_000776 O[C@H](C=C)[C@H]1CC(=NO1)c2ccccc2 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 G22 compound treatment 250620.0 -175000.0 -0.87 225720.0 -184000.0 -0.87 -1.2316 -1.0 3563153 BCB03_000777 COc1cc2CC(C)N(C)C(C3CC3)c2cc1OC 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 G23 compound treatment 444880.0 19100.0 0.1 376850.0 -33100.0 -0.16 -0.0428 -0.2346 3414065 BCB03_000778 O[C@@H]([C@H]1CC(=NO1)c2ccccc2)[C@@H]3CC(=NO3)c4ccccc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 G24 compound treatment 454240.0 28400.0 0.14 260320.0 -150000.0 -0.7 -0.3974 -0.5533 3563154 BCB03_000779 COCC#CC1N(C)C(C)Cc2cc(OC)c(OC)cc12 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 H01 compound treatment 536360.0 111000.0 0.55 533200.0 123000.0 0.58 0.8002 0.9997 3614478 BCB03_000780 COC(=O)c1cn(CC(=O)N2CCN(C)CC2)nn1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 H02 compound treatment 350020.0 -75800.0 -0.38 366100.0 -43900.0 -0.21 -0.4136 -0.9593 3061928 BCB03_000781 COc1cc2ncnc(Nc3ccc(F)c(Cl)c3)c2cc1OCCCN4CCOCC4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 H03 mock treatment 554650.0 129000.0 0.64 378880.0 -31100.0 -0.15 0.3516 0.5327 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 H04 mock treatment 517500.0 91700.0 0.46 478760.0 68800.0 0.32 0.5526 0.9855 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 H05 compound treatment 264160.0 -162000.0 -0.81 189780.0 -220000.0 -1.04 -1.3033 -0.9924 3614479 BCB03_000782 CCOC(=O)[C@H](Cc1ccccc1)NC(=O)Cn2cc(nn2)C(=O)OC 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 H06 compound treatment 258370.0 -167000.0 -0.84 284500.0 -125000.0 -0.59 -1.0087 -0.9855 3614483 BCB03_000783 COCCOc1cc2ncnc(Nc3cccc(C#C)c3)c2cc1OCCOC 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 H07 compound treatment 293920.0 -132000.0 -0.66 209480.0 -201000.0 -0.94 -1.1327 -0.9846 3614485 BCB03_000784 COC(=O)[C@@H](NC(=O)Cn1cc(nn1)C(=O)OC)c2ccccc2 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 H08 mock treatment 233830.0 -192000.0 -0.96 519650.0 110000.0 0.52 -0.3133 -0.2877 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 H09 compound treatment 534140.0 108000.0 0.54 256660.0 -153000.0 -0.72 -0.1274 -0.1413 3614488 BCB03_000785 CCOC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)Cn3cc(nn3)C(=O)OC 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 H10 mock treatment 565250.0 139000.0 0.7 502640.0 92700.0 0.44 0.8006 0.9745 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 H11 compound treatment 429520.0 3710.0 0.02 190920.0 -219000.0 -1.03 -0.7155 -0.6943 3614492 BCB03_000786 COC(=O)c1cn(nn1)c2cccc(N)c2 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 H12 mock treatment 472520.0 46700.0 0.23 319230.0 -90800.0 -0.43 -0.1369 -0.2814 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 H13 compound treatment 294900.0 -131000.0 -0.65 433760.0 23800.0 0.11 -0.3832 -0.5778 3614494 BCB03_000787 COC(=O)c1cn(CC(=O)N2CCN(CC2)c3ccccc3)nn1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 H14 mock treatment 395690.0 -30100.0 -0.15 508320.0 98300.0 0.46 0.2207 0.4538 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 H15 compound treatment 554110.0 128000.0 0.64 522430.0 112000.0 0.53 0.8271 0.9955 3614495 BCB03_000788 COC(=O)c1cn(CC(=O)N2CCOCC2)nn1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 H16 mock treatment 272250.0 -154000.0 -0.77 294080.0 -116000.0 -0.55 -0.9278 -0.986 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 H17 compound treatment 480800.0 55000.0 0.27 246780.0 -163000.0 -0.77 -0.3486 -0.4276 3614498 BCB03_000789 COC(=O)c1cn(CC(=O)Nc2ccc(OC)c(OC)c2)nn1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 H18 mock treatment 534900.0 109000.0 0.54 475800.0 65800.0 0.31 0.6042 0.9641 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 H19 mock treatment 366780.0 -59000.0 -0.29 404380.0 -5600.0 -0.03 -0.2271 -0.7673 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 H20 mock treatment 472930.0 47100.0 0.24 448800.0 38800.0 0.18 0.2955 0.9921 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 H21 compound treatment 416160.0 -9650.0 -0.05 493850.0 83900.0 0.39 0.2449 0.6162 3614499 BCB03_000790 COC(=O)c1cn(CC(=O)Nc2cc(OC)ccc2OC)nn1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 H22 mock treatment 469200.0 43400.0 0.22 537790.0 128000.0 0.6 0.5783 0.905 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 H23 compound treatment 427850.0 2040.0 0.01 368960.0 -41000.0 -0.19 -0.1292 -0.6688 3614501 BCB03_000791 COC(=O)c1cn(CC(=O)Nc2nccs2)nn1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 H24 mock treatment 472260.0 46500.0 0.23 382460.0 -27500.0 -0.13 0.0725 0.2729 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 I01 compound treatment 492450.0 66600.0 0.33 575590.0 166000.0 0.78 0.7862 0.9281 3071008 BCB03_000792 CC[C@H](C)C(=O)O[C@H]1CC[C@@]2(C)C(CCC3=C2CC[C@]4(C)[C@H](CC[C@@]34C)[C@H](C)CCCC(C)C)C1(C)C 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 I02 compound treatment 530280.0 104000.0 0.52 542720.0 133000.0 0.62 0.8104 0.996 3563155 BCB03_000793 COc1ccc(C[N+]2=Cc3cc(OC)c(OC)cc3CC2C)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 I03 compound treatment 398470.0 -27300.0 -0.14 415270.0 5290.0 0.02 -0.079 -0.569 3188792 BCB03_000794 CC(C)CCC[C@@H](C)[C@H]1CC[C@@]2(C)C3=C(CC[C@]12C)[C@@]4(C)CC[C@H](OC(=O)CCl)C(C)(C)C4CC3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 I04 compound treatment 348160.0 -77600.0 -0.39 364020.0 -46000.0 -0.22 -0.4271 -0.9619 3563156 BCB03_000795 COc1ccc(CN2C(C)Cc3cc(OC)c(OC)cc3C2C)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 I05 mock treatment 452740.0 26900.0 0.13 366160.0 -43800.0 -0.21 -0.0506 -0.2058 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 I06 mock treatment 540970.0 115000.0 0.58 534050.0 124000.0 0.58 0.8194 1.0 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 I07 compound treatment 496380.0 70600.0 0.35 491420.0 81400.0 0.38 0.5201 0.9991 3188805 BCB03_000796 CC(C)CCC[C@@H](C)[C@H]1CC[C@@]2(C)C3=C(CC[C@]12C)[C@@]4(C)CC[C@H](OC(=O)C(C)(C)C)C(C)(C)C4CC3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 I08 compound treatment 178460.0 -247000.0 -1.24 222400.0 -188000.0 -0.88 -1.4974 -0.9864 3563157 BCB03_000797 COc1ccc(CN2C(C)Cc3cc(OC)c(OC)cc3C2C=C)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 I09 compound treatment 495970.0 70200.0 0.35 244050.0 -166000.0 -0.78 -0.3041 -0.3555 3188806 BCB03_000798 CC(C)CCC[C@@H](C)[C@H]1CC[C@@]2(C)C3=C(CC[C@]12C)[C@@]4(C)CC[C@H](OC(=O)c5ccccc5)C(C)(C)C4CC3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 I10 compound treatment 181170.0 -245000.0 -1.22 205970.0 -204000.0 -0.96 -1.5425 -0.9929 3563158 BCB03_000799 COc1ccc(CN2C(C)Cc3cc(OC)c(OC)cc3C2C4CC4)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 I11 compound treatment 225950.0 -200000.0 -1.0 417760.0 7780.0 0.04 -0.68 -0.6807 3188807 BCB03_000800 COc1ccc(cc1)C(=O)O[C@H]2CC[C@@]3(C)C(CCC4=C3CC[C@]5(C)[C@H](CC[C@@]45C)[C@H](C)CCCC(C)C)C2(C)C 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 I12 compound treatment 335960.0 -89800.0 -0.45 143640.0 -266000.0 -1.25 -1.2032 -0.9041 3563159 BCB03_000801 COCC#CC1N(Cc2ccc(OC)cc2)C(C)Cc3cc(OC)c(OC)cc13 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 I13 compound treatment 495970.0 70200.0 0.35 500160.0 90200.0 0.42 0.5477 0.9955 3071124 BCB03_000802 COc1cccc(c1)C(=O)O[C@H]2CC[C@@]3(C)C(CCC4=C3CC[C@]5(C)[C@H](CC[C@@]45C)[C@H](C)CCCC(C)C)C2(C)C 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 I14 compound treatment 203000.0 -223000.0 -1.11 161920.0 -248000.0 -1.17 -1.6119 -0.9997 3614506 BCB03_000803 CCCCOc1ccc(/C=C/C(=O)NO)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 I15 compound treatment 268590.0 -157000.0 -0.79 184730.0 -225000.0 -1.06 -1.3044 -0.9891 3188924 BCB03_000804 CC(C)CCC[C@@H](C)[C@H]1CC[C@@]2(C)C3=C(CC[C@]12C)[C@@]4(C)CC[C@H](OC(=O)c5ccc(Br)cc5)C(C)(C)C4CC3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 I16 compound treatment 127890.0 -298000.0 -1.49 115590.0 -294000.0 -1.38 -2.0313 -0.9994 3614510 BCB03_000805 ONC(=O)/C=C/c1ccc(OC2CCCCC2)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 I17 compound treatment 295200.0 -131000.0 -0.65 488210.0 78200.0 0.37 -0.2011 -0.2685 3188925 BCB03_000806 CC(C)CCC[C@@H](C)[C@H]1CC[C@@]2(C)C3=C(CC[C@]12C)[C@@]4(C)CC[C@H](OC(=O)c5ccc(N)cc5)C(C)(C)C4CC3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 I18 compound treatment 292370.0 -133000.0 -0.67 190450.0 -220000.0 -1.03 -1.2014 -0.9776 3614513 BCB03_000807 COc1ccc(/C=C/C(=O)NO)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 I19 compound treatment 333330.0 -92500.0 -0.46 358640.0 -51300.0 -0.24 -0.4974 -0.9543 3614517 BCB03_000808 COC(=O)[C@H](Cc1ccccc1)N(CC#C)O[C@@H](/C=C/[C@@H](O)Cc2ccccc2)C3CC3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 I20 compound treatment 261850.0 -164000.0 -0.82 229060.0 -181000.0 -0.85 -1.1808 -0.9998 3614521 BCB03_000809 ONC(=O)/C=C/c1ccc(O)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 I21 mock treatment 363080.0 -62700.0 -0.31 385920.0 -24100.0 -0.11 -0.3016 -0.9053 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 I22 mock treatment 464520.0 38700.0 0.19 453620.0 43600.0 0.21 0.2818 0.9996 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 I23 compound treatment 276960.0 -149000.0 -0.74 171220.0 -239000.0 -1.12 -1.3198 -0.9799 3614524 BCB03_000810 COC(=O)[C@H](Cc1ccccc1)N2CC3=CCCC=C[C@H]3[C@@H]2[C@@H](O)Cc4ccccc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 I24 compound treatment 167480.0 -258000.0 -1.29 179900.0 -230000.0 -1.08 -1.6776 -0.9962 3614525 BCB03_000811 ONC(=O)/C=C/c1ccc(OCCc2ccccc2)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 J01 compound treatment 439110.0 13300.0 0.07 508400.0 98400.0 0.46 0.3743 0.8004 3614528 BCB03_000812 COC(=O)c1cn(CC(=O)Nc2ccon2)nn1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 J02 mock treatment 516320.0 90500.0 0.45 554310.0 144000.0 0.68 0.7997 0.9805 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 J03 compound treatment 519520.0 93700.0 0.47 480960.0 71000.0 0.33 0.567 0.9863 3614530 BCB03_000813 COC(=O)c1cn(C[C@H](Cc2ccccc2)NC(=O)Nc3ccccc3)nn1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 J04 mock treatment 534240.0 108000.0 0.54 544480.0 134000.0 0.63 0.8303 0.997 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 J05 mock treatment 185780.0 -240000.0 -1.2 530990.0 121000.0 0.57 -0.4452 -0.3355 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 J06 mock treatment 478560.0 52800.0 0.26 262640.0 -147000.0 -0.69 -0.3038 -0.4097 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 J07 compound treatment 493020.0 67200.0 0.34 414830.0 4850.0 0.02 0.2535 0.7534 3614532 BCB03_000814 O=C(Cn1cc(nn1)C2(CCCCC2)NC(=O)Nc3ccccc3)N4CCN(CC4)c5ccccc5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 J08 mock treatment 526460.0 101000.0 0.5 551170.0 141000.0 0.66 0.825 0.9906 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 J09 compound treatment 402180.0 -23600.0 -0.12 237970.0 -172000.0 -0.81 -0.6556 -0.8018 3614534 BCB03_000815 NC(=N)NCc1cn(CC(=O)N2CCN(CC2)c3ccccc3)nn1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 J10 mock treatment 509780.0 84000.0 0.42 289280.0 -121000.0 -0.57 -0.1049 -0.1486 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 J11 compound treatment 517940.0 92100.0 0.46 431150.0 21200.0 0.1 0.3958 0.8406 3614535 BCB03_000816 CC(=O)Nc1ccccc1c2cn(CC(=O)N3CCN(CC3)c4ccccc4)nn2 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 J12 mock treatment 234080.0 -192000.0 -0.96 235120.0 -175000.0 -0.82 -1.2587 -0.9971 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 J13 compound treatment 381030.0 -44800.0 -0.22 268800.0 -141000.0 -0.66 -0.6277 -0.8958 3614536 BCB03_000817 O=C(Cn1cc(nn1)C2(CCCCC2)NC(=O)Nc3ccccc3)N4CCOCC4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 J14 mock treatment 543680.0 118000.0 0.59 259630.0 -150000.0 -0.71 -0.0838 -0.0911 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 J15 compound treatment 524830.0 99000.0 0.49 558280.0 148000.0 0.7 0.8429 0.9858 3614537 BCB03_000818 CC(=O)Nc1ccccc1c2cn(CC(=O)N3CCOCC3)nn2 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 J16 mock treatment 442170.0 16400.0 0.08 555590.0 146000.0 0.68 0.5421 0.7859 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 J17 compound treatment 468110.0 42300.0 0.21 529530.0 120000.0 0.56 0.547 0.9106 3556424 BCB03_000819 COC(=O)c1c(C(=O)OC)c2oc1CC[C@H](CO)NC(=O)N[C@@H](Cc3ccccc3)C(=O)NCc4cn(C[C@H](Cc5ccccc5)NC2=O)nn4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 J18 mock treatment 322090.0 -104000.0 -0.52 563690.0 154000.0 0.72 0.1449 0.1629 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 J19 compound treatment 438510.0 12700.0 0.06 316160.0 -93800.0 -0.44 -0.2672 -0.5993 3614538 BCB03_000820 Cc1ccc(cc1)S(=O)(=O)N[C@@H](Cc2ccccc2)C(=O)NCCCn3cc(nn3)c4ccccc4N 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 J20 mock treatment 490890.0 65100.0 0.33 479070.0 69100.0 0.32 0.4596 1.0 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 J21 mock treatment 548210.0 122000.0 0.61 525090.0 115000.0 0.54 0.8151 0.9982 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 J22 mock treatment 517220.0 91400.0 0.46 378620.0 -31400.0 -0.15 0.2185 0.4554 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 J23 compound treatment 354470.0 -71300.0 -0.36 383680.0 -26300.0 -0.12 -0.3394 -0.8999 3614540 BCB03_000821 Cc1ccc(cc1)S(=O)(=O)N[C@@H](Cc2ccccc2)C(=O)NCCn3cc(nn3)c4ccccc4N 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 J24 mock treatment 522360.0 96600.0 0.48 296610.0 -113000.0 -0.53 -0.0361 -0.0502 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 K01 compound treatment 7730.0 -418000.0 -2.09 10920.0 -399000.0 -1.88 -2.8038 -0.9986 3614545 BCB03_000822 COC(=O)[C@H](Cc1ccccc1)N2CC3=CC(=O)[C@H](C4CC4)[C@H]3[C@@H]2[C@@H](O)Cc5ccccc5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 K02 compound treatment 157120.0 -269000.0 -1.34 168280.0 -242000.0 -1.14 -1.7528 -0.9966 3614548 BCB03_000823 COc1ccc(CCCOc2ccc(/C=C/C(=O)NO)cc2)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 K03 compound treatment 10660.0 -415000.0 -2.07 12220.0 -398000.0 -1.87 -2.7891 -0.9987 3614553 BCB03_000824 O=C1C=C2CN3[C@H]([C@@H]2[C@H]1C4CC4)[C@H](Cc5ccccc5)OC(=O)[C@@H]3Cc6ccccc6 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 K04 compound treatment 233610.0 -192000.0 -0.96 296740.0 -113000.0 -0.53 -1.0554 -0.9614 3614558 BCB03_000825 ONC(=O)/C=C/c1ccc(OCCc2ccccn2)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 K05 compound treatment 59420.0 -366000.0 -1.83 92800.0 -317000.0 -1.49 -2.3489 -0.9949 3614560 BCB03_000826 COC(=O)C1(CCCC1)N2CC3=CCCC=C[C@H]3[C@@H]2[C@@H](O)Cc4ccccc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 K06 compound treatment 93130.0 -333000.0 -1.66 118130.0 -292000.0 -1.37 -2.1456 -0.9955 3614562 BCB03_000827 ONC(=O)/C=C/c1ccc(OCCNCc2ccccc2)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 K07 mock treatment 523840.0 98000.0 0.49 267630.0 -142000.0 -0.67 -0.1273 -0.1534 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 K08 mock treatment 558080.0 132000.0 0.66 256540.0 -153000.0 -0.72 -0.0432 -0.0442 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 K09 compound treatment 588830.0 163000.0 0.81 334470.0 -75500.0 -0.36 0.3246 0.3654 3614565 BCB03_000828 C=C/C=C/[C@H]1[C@@H]2[C@H](Cc3ccccc3)OC(=O)C4(CCCC4)N2CC1=C 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 K10 compound treatment 198830.0 -227000.0 -1.13 228960.0 -181000.0 -0.85 -1.4037 -0.99 1065487 BCB03_000829 ONC(=O)CCCc1ccccc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 K11 compound treatment 235300.0 -191000.0 -0.95 444380.0 34400.0 0.16 -0.5584 -0.5786 3614570 BCB03_000830 O=C1O[C@@H](Cc2ccccc2)[C@H]3[C@@H]4C=CCCC=C4CN3C51CCCC5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 K12 compound treatment 247060.0 -179000.0 -0.89 288360.0 -122000.0 -0.57 -1.0358 -0.9769 3614573 BCB03_000831 CCCC(CCC)C(=O)NO 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 K13 compound treatment 498300.0 72500.0 0.36 170240.0 -240000.0 -1.13 -0.5414 -0.4571 3614575 BCB03_000832 COC(=O)C1(CCCC1)N2CC3=C[C@@H]([C@@H](O)Cc4ccccc4)n5n([C@@H]3[C@H](O2)C6CC6)c(=O)n(C)c5=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 K14 compound treatment 523750.0 97900.0 0.49 285460.0 -125000.0 -0.59 -0.0683 -0.0895 3614578 BCB03_000833 Oc1ccc2ncnc(NCC=C)c2c1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 K15 mock treatment 505570.0 79800.0 0.4 436380.0 26400.0 0.12 0.3695 0.8855 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 K16 mock treatment 370770.0 -55000.0 -0.27 175560.0 -234000.0 -1.1 -0.9741 -0.8572 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 K17 compound treatment 552440.0 127000.0 0.63 212700.0 -197000.0 -0.93 -0.2089 -0.1861 3614579 BCB03_000834 COC(=O)C1(CCCC1)N2CC3=C[C@@H](C4CC4)n5n([C@H]3[C@@H]2[C@@H](O)Cc6ccccc6)c(=O)n(C)c5=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 K18 compound treatment 556750.0 131000.0 0.65 440420.0 30400.0 0.14 0.5637 0.842 3614582 BCB03_000835 CCCNc1ncnc2ccc(O)cc12 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 K19 compound treatment 415390.0 -10400.0 -0.05 196020.0 -214000.0 -1.01 -0.7484 -0.7427 3614584 BCB03_000836 COC(=O)C1(CCCC1)N2C[C@](C)(OC)O[C@@H](Cc3ccccc3)[C@H]2/C=C/C4CC4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 K20 compound treatment 303320.0 -122000.0 -0.61 307930.0 -102000.0 -0.48 -0.772 -0.9928 2065681 BCB03_000837 CC1=C2[C@H](OB(O)C[C@@H]2[C@H]3[C@@H](C1)C(=O)N(Cc4ccccc4)C3=O)c5ccccc5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 K21 compound treatment 323240.0 -103000.0 -0.51 255140.0 -155000.0 -0.73 -0.8772 -0.9852 3614590 BCB03_000838 COC(=O)C1(CCCC1)N2CC(=C)[C@@H](/C=C/C=C)[C@@H]2[C@@H](O)Cc3ccccc3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 K22 compound treatment 343390.0 -82400.0 -0.41 354830.0 -55200.0 -0.26 -0.4745 -0.9752 3216001 BCB03_000839 COCC1=C2[C@H](OB(O)C[C@@H]2[C@H]3[C@@H](C1)C(=O)N(Cc4ccccc4)C3=O)c5ccccc5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 K23 mock treatment 549600.0 124000.0 0.62 515130.0 105000.0 0.49 0.7869 0.9939 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 K24 mock treatment 559880.0 134000.0 0.67 471940.0 62000.0 0.29 0.6796 0.9305 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 L01 compound treatment 524330.0 98500.0 0.49 565480.0 155000.0 0.73 0.8651 0.9814 3614594 BCB03_000840 Nc1ccccc1c2cn(CC(=O)Nc3nccs3)nn2 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 L02 mock treatment 494180.0 68400.0 0.34 522760.0 113000.0 0.53 0.6166 0.9773 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 L03 compound treatment 249800.0 -176000.0 -0.88 453710.0 43700.0 0.21 -0.4762 -0.5274 3614596 BCB03_000841 Nc1ccccc1c2cn(CC(=O)Nc3ccon3)nn2 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 L04 mock treatment 302630.0 -123000.0 -0.62 561630.0 152000.0 0.71 0.0693 0.0736 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 L05 compound treatment 466660.0 40900.0 0.2 511900.0 102000.0 0.48 0.4832 0.9275 3556414 BCB03_000842 COC(=O)c1c(C(=O)OC)c2oc1CC[C@@H](CO)NC(=O)N[C@H](Cc3ccccc3)c4cn(C[C@@H](Cc5ccccc5)NC2=O)nn4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 L06 mock treatment 263360.0 -162000.0 -0.81 524490.0 115000.0 0.54 -0.1929 -0.198 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 L07 mock treatment 563540.0 138000.0 0.69 563050.0 153000.0 0.72 0.9955 0.9997 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 L08 mock treatment 535170.0 109000.0 0.55 531920.0 122000.0 0.57 0.7918 0.9997 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 L09 compound treatment 509710.0 83900.0 0.42 513890.0 104000.0 0.49 0.6419 0.9971 3556416 BCB03_000843 COC(=O)c1c(C(=O)OC)c2oc1CC[C@@H](CO)NC(=O)N[C@H](Cc3ccccc3)c4cn(C[C@H](Cc5ccccc5)NC2=O)nn4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 L10 mock treatment 284440.0 -141000.0 -0.71 273310.0 -137000.0 -0.64 -0.9538 -0.9989 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 L11 compound treatment 488670.0 62900.0 0.31 188540.0 -221000.0 -1.04 -0.5145 -0.4729 3614599 BCB03_000844 CN1C(=O)[C@@H]2[C@H](C1=O)[C@]34COC[C@@H](N4C(=O)[C@@]2(O3)C(=O)C)c5ccccc5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 L12 mock treatment 194260.0 -232000.0 -1.16 301500.0 -108000.0 -0.51 -1.1786 -0.9324 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 L13 compound treatment 185210.0 -241000.0 -1.2 485080.0 75100.0 0.35 -0.5999 -0.479 3614605 BCB03_000845 Cc1ccc(cc1)S(=O)(=O)N2CCC[C@H]2Cn3cc(nn3)c4ccccc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 L14 mock treatment 180160.0 -246000.0 -1.23 272340.0 -138000.0 -0.65 -1.3253 -0.9554 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 L15 mock treatment 455860.0 30100.0 0.15 488610.0 78600.0 0.37 0.3676 0.9211 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 L16 mock treatment 388920.0 -36900.0 -0.18 575390.0 165000.0 0.78 0.4199 0.5251 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 L17 compound treatment 173410.0 -252000.0 -1.26 208890.0 -201000.0 -0.95 -1.5602 -0.99 3614607 BCB03_000846 CN1C(=O)[C@H]2[C@@H](C1=O)[C@@]34COC[C@@H](N4C(=O)[C@]2(O3)C(=O)C)c5ccccc5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 L18 mock treatment 386780.0 -39000.0 -0.19 509120.0 99100.0 0.47 0.1919 0.3797 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 L19 compound treatment 511730.0 85900.0 0.43 257710.0 -152000.0 -0.72 -0.203 -0.2431 3614609 BCB03_000847 CC(=O)[C@@]1(O[C@@]23COC[C@@H](N3C1=O)c4ccccc4)[C@H]5[C@@H]2C(=O)N(C5=O)c6ccccc6 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 L20 mock treatment 404400.0 -21400.0 -0.11 431040.0 21100.0 0.1 -0.0056 -0.0383 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 L21 compound treatment 367720.0 -58100.0 -0.29 380490.0 -29500.0 -0.14 -0.3032 -0.943 3614611 BCB03_000848 CC(=O)[C@]1(O[C@]23COC[C@@H](N3C1=O)c4ccccc4)[C@@H]5[C@H]2C(=O)N(C5=O)c6ccccc6 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 L22 mock treatment 447760.0 22000.0 0.11 413240.0 3260.0 0.02 0.0884 0.7981 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 L23 mock treatment 436800.0 11000.0 0.05 383890.0 -26100.0 -0.12 -0.048 -0.3568 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 L24 mock treatment 527900.0 102000.0 0.51 440030.0 30000.0 0.14 0.4605 0.8703 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 M01 compound treatment 10980.0 -415000.0 -2.07 13400.0 -397000.0 -1.87 -2.7841 -0.9986 3614612 BCB03_000849 COC(=O)[C@@H]1N2[C@H](SC1(C)C)[C@H](N3CC4=CC(=O)[C@H](C5CC5)[C@H]4[C@@H]3[C@@H](O)Cc6ccccc6)C2=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 M02 compound treatment 482320.0 56500.0 0.28 431380.0 21400.0 0.1 0.2707 0.9035 3215997 BCB03_000850 OB1C[C@@H]2[C@H]3[C@@H](CC(=C2[C@H](O1)c4ccccc4)COc5ccccc5)C(=O)N(Cc6ccccc6)C3=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 M03 compound treatment 363400.0 -62400.0 -0.31 504240.0 94300.0 0.44 0.0931 0.1718 3614614 BCB03_000851 COC(=O)[C@@H]1N2[C@H](SC1(C)C)[C@H](N3CC(=C)[C@@H](/C=C/C=C)[C@@H]3[C@@H](O)Cc4ccccc4)C2=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 M04 compound treatment 206500.0 -219000.0 -1.1 488210.0 78200.0 0.37 -0.5143 -0.4451 3216003 BCB03_000852 CN1C(=O)[C@@H]2CC(=C3[C@H](OB(O)C[C@@H]3[C@@H]2C1=O)c4ccccc4)C 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 M05 compound treatment 13920.0 -412000.0 -2.06 18210.0 -392000.0 -1.84 -2.7577 -0.9985 3614616 BCB03_000853 O=C1C=C2CN3[C@H]([C@@H]2[C@H]1C4CC4)[C@H](Cc5ccccc5)OC(=O)C63CCCC6 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 M06 compound treatment 493400.0 67600.0 0.34 431710.0 21700.0 0.1 0.311 0.8816 3215999 BCB03_000854 COCC1=C2[C@H](OB(O)C[C@@H]2[C@H]3[C@@H](C1)C(=O)N(C)C3=O)c4ccccc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 M07 compound treatment 491410.0 65600.0 0.33 544410.0 134000.0 0.63 0.6788 0.9532 3614620 BCB03_000855 COC(=O)[C@@H]1N2[C@H](SC1(C)C)[C@H](N[C@@H](/C=C/C3CC3)[C@H](O)Cc4ccccc4)C2=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 M08 compound treatment 189200.0 -237000.0 -1.18 471940.0 62000.0 0.29 -0.6296 -0.5172 3215995 BCB03_000856 CN1C(=O)[C@@H]2CC(=C3[C@H](OB(O)C[C@@H]3[C@@H]2C1=O)c4ccccc4)COc5ccccc5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 M09 mock treatment 427320.0 1510.0 0.01 537940.0 128000.0 0.6 0.4309 0.7159 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 M10 mock treatment 537070.0 111000.0 0.56 524800.0 115000.0 0.54 0.7748 0.9999 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 M11 compound treatment 268480.0 -157000.0 -0.79 249660.0 -160000.0 -0.75 -1.0889 -0.9998 3614624 BCB03_000857 COC(=O)[C@@H]1N2[C@H](SC1(C)C)[C@H](N(CC#C)[C@@H](/C=C/C3CC3)[C@H](O)Cc4ccccc4)C2=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 M12 compound treatment 502240.0 76400.0 0.38 210960.0 -199000.0 -0.94 -0.392 -0.3878 3215892 BCB03_000858 CC1=C2[C@H](OB(O)C[C@@H]2n3n(C1)c(=O)n(c4ccccc4)c3=O)c5ccccc5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 M13 mock treatment 532870.0 107000.0 0.53 387410.0 -22600.0 -0.11 0.303 0.5558 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 M14 mock treatment 228880.0 -197000.0 -0.98 500010.0 90000.0 0.42 -0.3961 -0.3699 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 M15 compound treatment 356750.0 -69100.0 -0.34 153810.0 -256000.0 -1.2 -1.0959 -0.8744 3614627 BCB03_000859 O[C@@H](Cc1ccccc1)[C@H]2O[C@@H](Cc3ccccc3)[C@@H](/C=C/C4CC4)N2CC#C 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 M16 compound treatment 392030.0 -33800.0 -0.17 289880.0 -120000.0 -0.56 -0.5188 -0.8799 3215890 BCB03_000860 COCC1=C2[C@H](OB(O)C[C@@H]2n3n(C1)c(=O)n(c4ccccc4)c3=O)c5ccccc5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 M17 compound treatment 333930.0 -91900.0 -0.46 193560.0 -216000.0 -1.02 -1.0443 -0.9352 3562141 BCB03_000861 COC(=O)[C@@H]1N2[C@H](SC1(C)C)[C@H](N(CC#C)[C@H](/C=C/C3CC3)[C@@H](O)Cc4ccccc4)C2=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 M18 compound treatment 231200.0 -195000.0 -0.97 199530.0 -210000.0 -0.99 -1.3873 -1.0 3215888 BCB03_000862 OB1C[C@H]2C(=C(COc3ccccc3)Cn4n2c(=O)n(c5ccccc5)c4=O)[C@H](O1)c6ccccc6 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 M19 compound treatment 241380.0 -184000.0 -0.92 223240.0 -187000.0 -0.88 -1.2724 -0.9997 3614632 BCB03_000863 O=C1O[C@H](C2CCCCC2)[C@H](/C=C/C3CC3)N(CC#C)C1Cc4ccccc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 M20 compound treatment 281500.0 -144000.0 -0.72 212000.0 -198000.0 -0.93 -1.1681 -0.992 3215943 BCB03_000864 CC1=C2[C@H](OB(O)C[C@@H]2[C@H]3[C@@H](C1)C(=O)c4ccccc4C3=O)c5ccccc5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 M21 compound treatment 223860.0 -202000.0 -1.01 218450.0 -192000.0 -0.9 -1.3503 -0.9984 3614636 BCB03_000865 O=C1O[C@@H]([C@@H]2[C@H]3C=CCCC=C3CN2C1Cc4ccccc4)C5CCCCC5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 M22 compound treatment 186420.0 -239000.0 -1.2 221460.0 -189000.0 -0.89 -1.4725 -0.9892 3215941 BCB03_000866 COCC1=C2[C@H](OB(O)C[C@@H]2[C@H]3[C@@H](C1)C(=O)c4ccccc4C3=O)c5ccccc5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 M23 compound treatment 218580.0 -207000.0 -1.04 232900.0 -177000.0 -0.83 -1.3208 -0.9942 3614641 BCB03_000867 COC(=O)[C@@H]1N2[C@H](SC1(C)C)[C@H](N3[C@H](/C=C/C4CC4)[C@H](Cc5ccccc5)OC3=O)C2=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 M24 compound treatment 262280.0 -164000.0 -0.82 209690.0 -200000.0 -0.94 -1.2437 -0.9975 3215939 BCB03_000868 OB1C[C@@H]2[C@H]3[C@@H](CC(=C2[C@H](O1)c4ccccc4)COc5ccccc5)C(=O)c6ccccc6C3=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 N01 compound treatment 528090.0 102000.0 0.51 542510.0 133000.0 0.62 0.802 0.9951 3614646 BCB03_000869 C=CCOC(=O)[C@@]1(O[C@@]23COC[C@@H](N3C1=O)c4ccccc4)[C@H]5[C@@H]2C(=O)N(C5=O)c6ccccc6 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 N02 mock treatment 515840.0 90000.0 0.45 531290.0 121000.0 0.57 0.7214 0.9931 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 N03 compound treatment 528260.0 102000.0 0.51 517820.0 108000.0 0.51 0.7205 1.0 3614650 BCB03_000870 C=CCOC(=O)[C@]1(O[C@]23COC[C@@H](N3C1=O)c4ccccc4)[C@@H]5[C@H]2C(=O)N(C5=O)c6ccccc6 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 N04 mock treatment 530600.0 105000.0 0.52 526310.0 116000.0 0.55 0.757 0.9998 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 N05 compound treatment 412410.0 -13400.0 -0.07 487710.0 77700.0 0.37 0.2112 0.5682 3614652 BCB03_000871 O=C(NCc1ccccc1)[C@@]2(O[C@@]34COC[C@@H](N4C2=O)c5ccccc5)[C@H]6[C@@H]3C(=O)N(C6=O)c7ccccc7 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 N06 mock treatment 367650.0 -58200.0 -0.29 551920.0 142000.0 0.67 0.2667 0.3663 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 N07 compound treatment 449920.0 24100.0 0.12 488420.0 78400.0 0.37 0.346 0.8916 3614656 BCB03_000872 O=C(NCCc1c[nH]c2ccccc12)[C@@]3(O[C@@]45COC[C@@H](N5C3=O)c6ccccc6)[C@H]7[C@@H]4C(=O)N(C7=O)c8ccccc8 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 N08 mock treatment 547780.0 122000.0 0.61 525890.0 116000.0 0.55 0.8163 0.9985 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 N09 mock treatment 491490.0 65700.0 0.33 458680.0 48700.0 0.23 0.3939 0.9846 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 N10 mock treatment 330880.0 -94900.0 -0.47 395760.0 -14200.0 -0.07 -0.3826 -0.799 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 N11 compound treatment 436480.0 10700.0 0.05 266260.0 -144000.0 -0.68 -0.4403 -0.6493 3614660 BCB03_000873 COC(=O)c1c(COC[C@@H](NC(=O)N(C)Cc2ccccc2)c3ccccc3)oc(C(=O)OCC=C)c1C(=O)OC 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 N12 mock treatment 469460.0 43700.0 0.22 225010.0 -185000.0 -0.87 -0.4611 -0.514 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 N13 mock treatment 313700.0 -112000.0 -0.56 211690.0 -198000.0 -0.93 -1.0555 -0.9702 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 N14 mock treatment 460340.0 34500.0 0.17 323130.0 -86900.0 -0.41 -0.1669 -0.3764 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 N15 compound treatment 172800.0 -253000.0 -1.26 224720.0 -185000.0 -0.87 -1.5097 -0.9835 3614664 BCB03_000874 COc1cc(/C=C(\C#N)/C(=O)Nc2nnc(s2)C(F)(F)F)ccc1OCc3ccc(cc3C(F)(F)F)C(F)(F)F 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 N16 mock treatment 540880.0 115000.0 0.57 220500.0 -189000.0 -0.89 -0.2238 -0.2111 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 N17 compound treatment 497500.0 71700.0 0.36 294470.0 -116000.0 -0.54 -0.131 -0.2013 1917883 BCB03_000875 O/N=C/1\C2(CCCCC2)C(=O)N(O)C31CCCC=C3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 N18 mock treatment 353410.0 -72400.0 -0.36 315520.0 -94500.0 -0.44 -0.5699 -0.9948 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 N19 compound treatment 206180.0 -220000.0 -1.1 153890.0 -256000.0 -1.2 -1.6274 -0.9989 3614668 BCB03_000876 C[C@@]12CCC3[C@@]4(C)CC[C@H](O)CC54C=CC3(C2CC[C@@]1(O)CN6CCC(CC6)n7c(=O)[nH]c8ccccc78)C(=C5)C(=O)c9cc%10ccccc%10s9 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 N20 mock treatment 430050.0 4240.0 0.02 315320.0 -94700.0 -0.45 -0.2999 -0.6727 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 N21 compound treatment 218580.0 -207000.0 -1.04 186400.0 -224000.0 -1.05 -1.4755 -1.0 3614669 BCB03_000877 C[C@@]12CCC3[C@@]4(C)CC[C@H](O)CC54C=CC3(C2CC[C@@]1(O)CN6CCC(CC6)n7c(=O)[nH]c8ccccc78)C(=C5)C(=O)C9CCCCC9 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 N22 mock treatment 248420.0 -177000.0 -0.89 316580.0 -93400.0 -0.44 -0.9371 -0.9476 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 N23 compound treatment 248170.0 -178000.0 -0.89 237780.0 -172000.0 -0.81 -1.2001 -0.999 3614671 BCB03_000878 C[C@@]12CCC3[C@@]4(C)CC[C@H](O)CC54C=CC3(C2CC[C@@]1(O)CN6CCC(CC6)C(=O)N)C(=C5)C(=O)c7ccc(F)c(F)c7 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 N24 mock treatment 306110.0 -120000.0 -0.6 349190.0 -60800.0 -0.29 -0.6249 -0.943 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 O01 compound treatment 131100.0 -295000.0 -1.47 134810.0 -275000.0 -1.29 -1.956 -0.9979 3614673 BCB03_000879 COC(=O)[C@H](Cc1ccccc1)N2[C@@H](/C=C/C3CC3)[C@@H](Cc4ccccc4)OC2=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 O02 compound treatment 552130.0 126000.0 0.63 548070.0 138000.0 0.65 0.9054 0.9999 2065712 BCB03_000880 CC1=C([C@H](O)c2ccccc2)[C@H](CO)[C@H]3[C@@H](C1)C(=O)N(Cc4ccccc4)C3=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 O03 compound treatment 459710.0 33900.0 0.17 557810.0 148000.0 0.7 0.6114 0.8543 3614677 BCB03_000881 COC(=O)C1(CCCC1)N2[C@H](/C=C/C3CC3)[C@H](Cc4ccccc4)OC2=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 O04 compound treatment 249730.0 -176000.0 -0.88 502730.0 92700.0 0.44 -0.3134 -0.3192 3215981 BCB03_000882 COCC1=C([C@H](O)c2ccccc2)[C@H](CO)[C@H]3[C@@H](C1)C(=O)N(Cc4ccccc4)C3=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 O05 compound treatment 378610.0 -47200.0 -0.24 172830.0 -237000.0 -1.12 -0.9555 -0.838 3614680 BCB03_000883 COC(=O)[C@H](Cc1ccccc1)N2[C@H](/C=C/C3CC3)[C@H](Cc4ccccc4)OC2=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 O06 compound treatment 212430.0 -213000.0 -1.07 218790.0 -191000.0 -0.9 -1.3895 -0.9964 3215977 BCB03_000884 OC[C@@H]1[C@H]2[C@@H](CC(=C1[C@H](O)c3ccccc3)COc4ccccc4)C(=O)N(Cc5ccccc5)C2=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 O07 compound treatment 400640.0 -25200.0 -0.13 494250.0 84300.0 0.4 0.1914 0.4603 3563099 BCB03_000885 COC(=O)C1=CN(C)C(C)c2ccccc2C=C1C(=O)OC 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 O08 compound treatment 310670.0 -115000.0 -0.58 304200.0 -106000.0 -0.5 -0.7585 -0.9974 2065737 BCB03_000886 CN1C(=O)[C@@H]2CC(=C([C@H](O)c3ccccc3)[C@H](CO)[C@@H]2C1=O)C 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 O09 compound treatment 429290.0 3480.0 0.02 521700.0 112000.0 0.53 0.3839 0.7301 3563100 BCB03_000887 CCOC(=O)C1=C2[C@@H](ON1)N(C)[C@H](C)c3ccccc23 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 O10 compound treatment 539850.0 114000.0 0.57 264390.0 -146000.0 -0.68 -0.0815 -0.0915 3215979 BCB03_000888 COCC1=C([C@H](O)c2ccccc2)[C@H](CO)[C@H]3[C@@H](C1)C(=O)N(C)C3=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 O11 mock treatment 360290.0 -65500.0 -0.33 441480.0 31500.0 0.15 -0.1266 -0.3525 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 O12 mock treatment 452680.0 26900.0 0.13 436160.0 26200.0 0.12 0.182 0.9991 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 O13 compound treatment 493150.0 67300.0 0.34 497280.0 87300.0 0.41 0.5282 0.9951 3563102 BCB03_000889 CCOC(=O)C1=C2[C@@H](ON1)N(C)[C@@H](C)c3ccccc23 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 O14 compound treatment 219600.0 -206000.0 -1.03 390020.0 -20000.0 -0.09 -0.7947 -0.7684 3215975 BCB03_000890 CN1C(=O)[C@@H]2CC(=C([C@H](O)c3ccccc3)[C@H](CO)[C@@H]2C1=O)COc4ccccc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 O15 compound treatment 475620.0 49800.0 0.25 471050.0 61100.0 0.29 0.379 0.9974 3563103 BCB03_000891 CC1N(C)/C(=N\P(=O)(Oc2ccccc2)Oc3ccccc3)/Cc4ccccc14 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 O16 compound treatment 545310.0 120000.0 0.6 462250.0 52300.0 0.25 0.5959 0.9231 3215878 BCB03_000892 CC1=C([C@H](O)c2ccccc2)[C@H](CO)n3n(C1)c(=O)n(c4ccccc4)c3=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 O17 compound treatment 269570.0 -156000.0 -0.78 261890.0 -148000.0 -0.7 -1.0443 -0.9984 3563106 BCB03_000893 CN/1C(C=C)c2ccccc2C\C1=N\P(=O)(Oc3ccccc3)Oc4ccccc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 O18 compound treatment 411200.0 -14600.0 -0.07 253280.0 -157000.0 -0.74 -0.5728 -0.7733 3215876 BCB03_000894 COCC1=C([C@H](O)c2ccccc2)[C@H](CO)n3n(C1)c(=O)n(c4ccccc4)c3=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 O19 compound treatment 512480.0 86700.0 0.43 314880.0 -95100.0 -0.45 -0.0102 -0.0164 3563109 BCB03_000895 CCOC(=O)C1=C2[C@H](ON1)N(C)[C@@H](C3CC3)c4ccccc24 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 O20 compound treatment 288350.0 -137000.0 -0.69 219970.0 -190000.0 -0.89 -1.1174 -0.9915 3215874 BCB03_000896 OC[C@H]1C(=C(COc2ccccc2)Cn3n1c(=O)n(c4ccccc4)c3=O)[C@H](O)c5ccccc5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 O21 compound treatment 407630.0 -18200.0 -0.09 351050.0 -58900.0 -0.28 -0.2602 -0.8921 3563111 BCB03_000897 CCOC(=O)C1=C2[C@@H](ON1)N(C)[C@@H](C3CC3)c4ccccc24 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 O22 compound treatment 359910.0 -65900.0 -0.33 319420.0 -90600.0 -0.43 -0.5339 -0.9919 3216007 BCB03_000898 C[C@]1(C[C@@H]2[C@H]([C@H]/3CO1)C(=O)N(Cc4ccccc4)C2=O)\C3=C\c5ccccc5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 O23 compound treatment 450740.0 24900.0 0.12 515590.0 106000.0 0.5 0.4393 0.8578 3563112 BCB03_000899 CN/1C(C2CC2)c3ccccc3C\C1=N\P(=O)(Oc4ccccc4)Oc5ccccc5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 O24 compound treatment 311360.0 -114000.0 -0.57 277640.0 -132000.0 -0.62 -0.8444 -0.9991 3216011 BCB03_000900 COC[C@]1(C[C@@H]2[C@H]([C@H]/3CO1)C(=O)N(Cc4ccccc4)C2=O)\C3=C\c5ccccc5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 P01 compound treatment 146640.0 -279000.0 -1.39 313760.0 -96200.0 -0.45 -1.306 -0.8909 3614688 BCB03_000901 COc1ccc(cc1OC2CCCC2)C3=NOC(C3)C(=O)NO 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 P02 mock treatment 469330.0 43500.0 0.22 453210.0 43200.0 0.2 0.2975 0.9994 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 P03 compound treatment 380360.0 -45400.0 -0.23 369600.0 -40400.0 -0.19 -0.2948 -0.9961 3614690 BCB03_000902 CC(=O)c1ccc(NC(=S)Nc2ccc(Nc3ccccc3)cc2)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 P04 mock treatment 466690.0 40900.0 0.2 411570.0 1590.0 0.01 0.1497 0.7324 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 P05 compound treatment 241960.0 -184000.0 -0.92 436440.0 26500.0 0.12 -0.5613 -0.6057 3614693 BCB03_000903 COC(=O)c1cn(CC(=O)O)nn1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 P06 mock treatment 456530.0 30700.0 0.15 418130.0 8150.0 0.04 0.1356 0.8573 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 P07 compound treatment 176890.0 -249000.0 -1.24 420110.0 10100.0 0.05 -0.8454 -0.6795 3614695 BCB03_000904 COC(=O)c1cn(CCC(=O)O)nn1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 P08 mock treatment 355050.0 -70800.0 -0.35 341640.0 -68300.0 -0.32 -0.4772 -0.9989 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 P09 compound treatment 336160.0 -89600.0 -0.45 344880.0 -65100.0 -0.31 -0.5331 -0.9828 1366116 BCB03_000905 Brc1ccc2ncnc(NCC=C)c2c1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 P10 mock treatment 202880.0 -223000.0 -1.11 201760.0 -208000.0 -0.98 -1.4799 -0.998 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 P11 mock treatment 251210.0 -175000.0 -0.87 425560.0 15600.0 0.07 -0.5648 -0.6454 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 P12 mock treatment 248000.0 -178000.0 -0.89 265230.0 -145000.0 -0.68 -1.1094 -0.9914 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 P13 compound treatment 156320.0 -269000.0 -1.35 161560.0 -248000.0 -1.17 -1.778 -0.9975 1263689 BCB03_000906 Brc1ccc2ncnc(NCc3ccccc3)c2c1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 P14 mock treatment 437000.0 11200.0 0.06 252590.0 -157000.0 -0.74 -0.484 -0.6519 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 P15 compound treatment 300860.0 -125000.0 -0.62 293050.0 -117000.0 -0.55 -0.8302 -0.998 1385097 BCB03_000907 CCCNc1ncnc2ccc(Br)cc12 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 P16 mock treatment 482780.0 57000.0 0.28 441780.0 31800.0 0.15 0.307 0.9549 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 P17 compound treatment 312010.0 -114000.0 -0.57 279640.0 -130000.0 -0.61 -0.8354 -0.9993 3614697 BCB03_000908 CC(C)(C)OC(=O)NCCOCCOCCNc1ncnc2ccc(Br)cc12 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 P18 mock treatment 370030.0 -55800.0 -0.28 371770.0 -38200.0 -0.18 -0.3241 -0.9775 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 P19 compound treatment 410100.0 -15700.0 -0.08 331630.0 -78400.0 -0.37 -0.3161 -0.8388 3614698 BCB03_000909 CCOc1ncnc2ccc(Br)cc12 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 P20 mock treatment 372610.0 -53200.0 -0.27 367970.0 -42000.0 -0.2 -0.3276 -0.9894 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 P21 compound treatment 375200.0 -50600.0 -0.25 365690.0 -44300.0 -0.21 -0.3261 -0.9954 1985613 BCB03_000910 C=CCNc1ncnc2ccccc12 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 P22 mock treatment 343320.0 -82500.0 -0.41 417330.0 7350.0 0.03 -0.2669 -0.6455 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 P23 compound treatment 208890.0 -217000.0 -1.08 232910.0 -177000.0 -0.83 -1.355 -0.9916 1412880 BCB03_000911 C(Nc1ncnc2ccccc12)c3ccccc3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2283 P24 mock treatment 428410.0 2600.0 0.01 322980.0 -87000.0 -0.41 -0.2802 -0.6843 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 A01 mock treatment 526630.0 136000.0 0.68 379120.0 43800.0 0.21 0.6273 0.8815 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 A02 compound treatment 155270.0 -235000.0 -1.17 457720.0 122000.0 0.58 -0.4228 -0.3234 3555546 CMLD3_000001 COc1ccc2O[C@@H]([C@@H](OC(=O)Nc3cc(OC)c(OC)c(OC)c3)C(=O)c2c1)c4ccc(OC)c(Br)c4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 A03 mock treatment 166660.0 -224000.0 -1.12 193600.0 -142000.0 -0.67 -1.261 -0.9696 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 A04 compound treatment 430320.0 40100.0 0.2 147840.0 -187000.0 -0.88 -0.4821 -0.5331 3555566 CMLD3_000002 COc1ccc2C(=O)[C@@H](OC(=O)NCCOc3ccccc3)[C@@H](Oc2c1)c4ccc5OCOc5c4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 A05 compound treatment 440290.0 50000.0 0.25 162260.0 -173000.0 -0.81 -0.3989 -0.4684 3555570 CMLD3_000003 COc1cccc(c1)[C@@H]2Oc3ccc(OC)cc3C[C@H]2OC(=O)NS(=O)(=O)c4ccc(C)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 A06 compound treatment 234720.0 -156000.0 -0.78 189190.0 -146000.0 -0.69 -1.0353 -0.9981 3555574 CMLD3_000004 COc1ccc2O[C@H]([C@H](O)C(=O)c2c1)c3ccc(OC)c(Br)c3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 A07 mock treatment 175400.0 -215000.0 -1.07 223840.0 -111000.0 -0.52 -1.1296 -0.9458 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 A08 compound treatment 192340.0 -198000.0 -0.99 210080.0 -125000.0 -0.59 -1.1155 -0.9694 3555579 CMLD3_000005 COc1ccc2O[C@H]([C@H](OC(=O)NCCOc3ccccc3)C(=O)c2c1)c4ccc(OC)c(Br)c4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 A09 compound treatment 187360.0 -203000.0 -1.01 336880.0 1560.0 0.01 -0.7114 -0.702 3555584 CMLD3_000006 Brc1ccc2O[C@H]([C@H](OC(=O)NCc3ccc4OCOc4c3)C(=O)c2c1)c5ccc6OCOc6c5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 A10 compound treatment 360430.0 -29800.0 -0.15 187950.0 -147000.0 -0.69 -0.5955 -0.8399 3555589 CMLD3_000007 COC(=O)[C@H](COC(C)(C)C)NC(=O)O[C@@H]1Cc2cc(Br)ccc2O[C@H]1c3cccc(OC)c3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 A11 mock treatment 211840.0 -178000.0 -0.89 173210.0 -162000.0 -0.76 -1.1693 -0.997 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 A12 compound treatment 433720.0 43500.0 0.22 193220.0 -142000.0 -0.67 -0.3191 -0.4541 3555594 CMLD3_000008 COC(=O)[C@H](COC(C)(C)C)NC(=O)O[C@@H]1[C@H](Oc2cc(OC)ccc2C1=O)c3ccc4OCOc4c3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 A13 mock treatment 250180.0 -140000.0 -0.7 183130.0 -152000.0 -0.72 -1.0009 -0.9999 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 A14 mock treatment 160680.0 -230000.0 -1.15 166570.0 -169000.0 -0.79 -1.372 -0.9839 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 A15 compound treatment 171000.0 -219000.0 -1.1 179170.0 -156000.0 -0.73 -1.2937 -0.9811 3555598 CMLD3_000009 CCOC(=O)OC[C@H]1O[C@@H](C=C[C@@H]1OC(=O)OCC)c2cc(C)cc(C)c2 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 A16 compound treatment 184670.0 -206000.0 -1.03 281130.0 -54200.0 -0.25 -0.9063 -0.8566 3555600 CMLD3_000010 Cc1cc(C)cc(/C=C/[C@H]2OC[C@@H](O)[C@H]2Oc3ccc(cc3)C4CCCC4)c1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 A17 compound treatment 136480.0 -254000.0 -1.27 141140.0 -194000.0 -0.91 -1.5421 -0.9871 3555605 CMLD3_000011 COc1ccc(C#C[C@H]2O[C@H](CO)[C@@H](Oc3cc(C)cc(C)c3)C=C2)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 A18 compound treatment 26560.0 -364000.0 -1.82 22400.0 -313000.0 -1.47 -2.3252 -0.9946 3555609 CMLD3_000012 CC(C)(C)OC(=O)C1=NOC2(C1)C=CC(=O)C=C2 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 A19 compound treatment 387200.0 -3050.0 -0.02 180580.0 -155000.0 -0.73 -0.5255 -0.7218 3555611 CMLD3_000013 COC(=O)N[C@@H](c1ccccc1)[C@@]2(CCCC2=O)C(=O)OC 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 A20 compound treatment 427450.0 37200.0 0.19 169490.0 -166000.0 -0.78 -0.4202 -0.524 3555615 CMLD3_000014 CCCCCCCC#Cc1ccccc1C(NC(=O)OC)C(C(=O)OC)C(=O)OC 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 A21 compound treatment 520800.0 131000.0 0.65 288650.0 -46700.0 -0.22 0.3058 0.4445 3555617 CMLD3_000015 CC(C)(C)OC1C2C3C2C4C1C3CC=CC4(O)CC=C 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 A22 compound treatment 258790.0 -131000.0 -0.66 352330.0 17000.0 0.08 -0.4077 -0.6164 3555619 CMLD3_000016 COCn1c2ccccc2c3nnc(nc13)C(=O)O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 A23 compound treatment 175960.0 -214000.0 -1.07 241880.0 -93400.0 -0.44 -1.0676 -0.9227 3555621 CMLD3_000017 COC(=O)N[C@H](/C(=C(\C)/NCc1ccccc1)/C(=O)OC)c2cccs2 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 A24 compound treatment 410420.0 20200.0 0.1 263150.0 -72200.0 -0.34 -0.1688 -0.4768 3555626 CMLD3_000018 CC(=CCC/C(=C/C=C/C1=CC2(C)CC1(C)C(CC2=O)\C=C(/C)\CCC=C(C)C)/C)C 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 B01 compound treatment 538240.0 148000.0 0.74 454810.0 119000.0 0.56 0.92 0.9909 3555630 CMLD3_000019 COc1cccc(c1)[C@@H]2Oc3ccc(Br)cc3C[C@H]2OC(=O)NS(=O)(=O)c4ccc(C)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 B02 compound treatment 243300.0 -147000.0 -0.73 214330.0 -121000.0 -0.57 -0.9214 -0.9921 3555635 CMLD3_000020 COc1ccc2C(=O)[C@H](OC(=O)Nc3cc(OC)c(OC)c(OC)c3)[C@H](Oc2c1)c4ccc5OCOc5c4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 B03 compound treatment 512170.0 122000.0 0.61 451760.0 116000.0 0.55 0.8178 0.9986 3555639 CMLD3_000021 COc1ccc2C(=O)[C@@H](OC(=O)Nc3ccc(OC(F)F)cc3)[C@@H](Oc2c1)c4ccc5OCOc5c4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 B04 compound treatment 455420.0 65200.0 0.33 226810.0 -109000.0 -0.51 -0.1308 -0.216 3555643 CMLD3_000022 COc1ccc2C(=O)[C@@H](OC(=O)N[C@H]3CCCc4ccccc34)[C@@H](Oc2c1)c5ccc6OCOc6c5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 B05 compound treatment 411520.0 21300.0 0.11 280670.0 -54700.0 -0.26 -0.1067 -0.3835 3555647 CMLD3_000023 COc1ccc2C(=O)[C@@H](O)[C@@H](Oc2c1)c3ccc4OCOc4c3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 B06 compound treatment 257200.0 -133000.0 -0.66 338430.0 3110.0 0.01 -0.4596 -0.6914 3555651 CMLD3_000024 COc1ccc2C(=O)[C@H](O)[C@H](Oc2c1)c3ccc4OCOc4c3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 B07 compound treatment 497150.0 107000.0 0.53 447640.0 112000.0 0.53 0.7511 1.0 3555653 CMLD3_000025 CCOC(=O)CNC(=O)O[C@H]1[C@@H](Oc2ccc(Br)cc2C1=O)c3cccc(OC)c3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 B08 compound treatment 448090.0 57800.0 0.29 477160.0 142000.0 0.67 0.676 0.9299 3555657 CMLD3_000026 COc1ccc2C(=O)[C@H](OC(=O)N[C@H]3CCCc4ccccc34)[C@H](Oc2c1)c5ccc6OCOc6c5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 B09 compound treatment 418900.0 28600.0 0.14 449210.0 114000.0 0.54 0.48 0.8656 3555659 CMLD3_000027 COc1ccc2C(=O)[C@H](OC(=O)N[C@H](C)C3CCCCC3)[C@H](Oc2c1)c4ccc5OCOc5c4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 B10 compound treatment 488690.0 98400.0 0.49 465770.0 130000.0 0.61 0.7815 0.994 3555663 CMLD3_000028 COc1cccc(c1)[C@@H]2Oc3ccc(Br)cc3C[C@H]2O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 B11 compound treatment 311630.0 -78600.0 -0.39 512050.0 177000.0 0.83 0.3101 0.3373 3555666 CMLD3_000029 COc1ccc2O[C@H]([C@H](OC(=O)Nc3ccc(C)c(Br)c3)C(=O)c2c1)c4ccc(OC)c(Br)c4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 B12 compound treatment 555550.0 165000.0 0.83 476710.0 141000.0 0.67 1.054 0.9943 3555670 CMLD3_000030 COc1ccc2C(=O)[C@H](OC(=O)NCCOc3ccccc3)[C@H](Oc2c1)c4ccc5OCOc5c4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 B13 mock treatment 470680.0 80400.0 0.4 463950.0 129000.0 0.61 0.7118 0.9802 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 B14 mock treatment 482960.0 92700.0 0.46 479220.0 144000.0 0.68 0.806 0.9829 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 B15 compound treatment 406310.0 16100.0 0.08 329280.0 -6040.0 -0.03 0.0366 0.4302 3555672 CMLD3_000031 CC(=O)c1ccc(cc1)[C@H]2O[C@H](CO)[C@@H](Oc3ccc(cc3)c4ccccc4)C=C2 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 B16 compound treatment 239740.0 -151000.0 -0.75 263000.0 -72300.0 -0.34 -0.7721 -0.9357 3555676 CMLD3_000032 CC(C)(C)c1ccc(O[C@@H]2[C@H](O)CO[C@H]2/C=C/C#Cc3ccccc3)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 B17 compound treatment 212730.0 -178000.0 -0.89 211040.0 -124000.0 -0.58 -1.0403 -0.9796 3555680 CMLD3_000033 CC(=O)c1ccc(O[C@H]2C=C[C@H](O[C@@H]2CO)C#Cc3ccc(Br)cc3)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 B18 compound treatment 476380.0 86100.0 0.43 240070.0 -95300.0 -0.45 -0.0126 -0.0204 3555686 CMLD3_000034 COc1ccc(/C=C/C2=CC3(C)CC2(C)C(CC3=O)c4ccc(OC)cc4)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 B19 compound treatment 336740.0 -53500.0 -0.27 465520.0 130000.0 0.61 0.244 0.3652 3555689 CMLD3_000035 COC(=O)N[C@H](CC(=O)C)c1ccc2OCOc2c1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 B20 mock treatment 468750.0 78500.0 0.39 379100.0 43800.0 0.21 0.4228 0.9548 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 B21 compound treatment 367260.0 -23000.0 -0.11 288100.0 -47200.0 -0.22 -0.2383 -0.9529 3555694 CMLD3_000036 COCO[C@@H]1[C@@H](C)C(=O)N2[C@@H]1[C@@H](Oc3ccc(OC)cc23)/C=C/C 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 B22 compound treatment 377080.0 -13200.0 -0.07 393880.0 58600.0 0.28 0.1482 0.5235 3555700 CMLD3_000037 C[C@@H]1C=CCCO[C@H]1c2ccccc2 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 B23 compound treatment 354810.0 -35400.0 -0.18 294330.0 -41000.0 -0.19 -0.2615 -0.9991 3555703 CMLD3_000038 CCCCCCCC#Cc1ccccc1/C=N/S(=O)c2ccc(C)cc2 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 B24 compound treatment 457680.0 67400.0 0.34 473400.0 138000.0 0.65 0.6974 0.9532 3555707 CMLD3_000039 COc1ccc(/C=C/N(CCc2ccc(OC)c(OC)c2)C(=O)c3ccccn3)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 C01 compound treatment 434590.0 44300.0 0.22 430400.0 95100.0 0.45 0.4728 0.9474 3555711 CMLD3_000040 COc1cccc(c1)[C@@H]2Oc3ccc(Br)cc3[C@H](O)[C@H]2O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 C02 compound treatment 438240.0 48000.0 0.24 364000.0 28700.0 0.13 0.2648 0.963 3555810 CMLD3_000041 COc1ccc2C(=O)[C@@H](OC(=O)NCCc3ccc(OC)c(OC)c3)[C@@H](Oc2c1)c4cccc(c4)C(F)(F)F 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 C03 compound treatment 473980.0 83700.0 0.42 255360.0 -80000.0 -0.38 0.0297 0.0529 3555814 CMLD3_000042 CCOC(=O)CNC(=O)O[C@@H]1[C@H](Oc2cc(OC)ccc2C1=O)c3ccc4OCOc4c3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 C04 compound treatment 422320.0 32100.0 0.16 225150.0 -110000.0 -0.52 -0.2532 -0.4668 3555817 CMLD3_000043 COC(=O)[C@H](Cc1ccccc1)NC(=O)O[C@@H]2[C@H](Oc3ccc(OC)cc3C2=O)c4ccc(OC)c(Br)c4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 C05 compound treatment 242740.0 -148000.0 -0.74 227720.0 -108000.0 -0.51 -0.8789 -0.9832 3555820 CMLD3_000044 COc1ccc2O[C@@H]([C@@H](OC(=O)NS(=O)(=O)c3ccc(F)cc3)C(=O)c2c1)c4ccc(OC)c(Br)c4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 C06 compound treatment 199840.0 -190000.0 -0.95 387800.0 52500.0 0.25 -0.4979 -0.5068 3555823 CMLD3_000045 COc1cccc(c1)[C@@H]2Oc3ccc(Br)cc3C[C@H]2OC(=O)Nc4ccc(C)c(Br)c4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 C07 compound treatment 485440.0 95200.0 0.48 242960.0 -92400.0 -0.43 0.029 0.045 3555825 CMLD3_000046 CCOC(=O)CNC(=O)O[C@H]1[C@@H](Oc2ccc(OC)cc2C1=O)c3cccc(OC)c3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 C08 compound treatment 431490.0 41200.0 0.21 269340.0 -66000.0 -0.31 -0.0738 -0.1982 3555829 CMLD3_000047 COc1cccc(c1)[C@@H]2Oc3ccc(OC)cc3C(=O)[C@H]2OC(=O)NC4CCCC4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 C09 compound treatment 462630.0 72400.0 0.36 453040.0 118000.0 0.55 0.6471 0.9786 3555833 CMLD3_000048 COC(=O)[C@H](Cc1ccccc1)NC(=O)O[C@@H]2[C@H](Oc3cc(OC)ccc3C2=O)c4ccc5OCOc5c4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 C10 compound treatment 260220.0 -130000.0 -0.65 430560.0 95200.0 0.45 -0.1425 -0.1806 3555837 CMLD3_000049 COc1cccc(c1)[C@@H]2Oc3ccc(OC)cc3C[C@H]2OC(=O)NS(=O)(=O)c4ccc(F)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 C11 mock treatment 467280.0 77000.0 0.38 454200.0 119000.0 0.56 0.6674 0.9833 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 C12 mock treatment 484990.0 94700.0 0.47 398760.0 63400.0 0.3 0.5456 0.9753 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 C13 compound treatment 385650.0 -4600.0 -0.02 260230.0 -75100.0 -0.35 -0.266 -0.7515 3555841 CMLD3_000050 COC(=O)[C@H](Cc1ccccc1)NC(=O)O[C@@H]2Cc3cc(OC)ccc3O[C@H]2c4cccc(OC)c4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 C14 compound treatment 280810.0 -109000.0 -0.55 246010.0 -89300.0 -0.42 -0.6836 -0.9915 3555844 CMLD3_000051 CC(=O)c1ccc(O[C@H]2C=C[C@H](O[C@@H]2CO)c3ccc(Cl)cc3)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 C15 mock treatment 388870.0 -1380.0 -0.01 292080.0 -43200.0 -0.2 -0.1487 -0.7307 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 C16 mock treatment 218880.0 -171000.0 -0.86 254500.0 -80800.0 -0.38 -0.874 -0.9333 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 C17 compound treatment 212350.0 -178000.0 -0.89 244160.0 -91200.0 -0.43 -0.9315 -0.9442 3555848 CMLD3_000052 CCOC(=O)OC[C@H]1O[C@@H](C=C[C@@H]1Oc2cccc(c2)N(C)C)C#Cc3ccccc3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 C18 compound treatment 423400.0 33100.0 0.17 325780.0 -9540.0 -0.04 0.0853 0.4974 3555853 CMLD3_000053 COC(=O)C1(CC2(CCC3C4C5C41)OCCO2)C3C5OCc6ccccc6 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 C19 compound treatment 229920.0 -160000.0 -0.8 242110.0 -93200.0 -0.44 -0.8763 -0.9598 3555855 CMLD3_000054 COc1cccc(/C=C/C2=CC3(C)CC2(C)C(CC3=O)c4cccc(OC)c4)c1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 C20 compound treatment 189120.0 -201000.0 -1.0 171040.0 -164000.0 -0.77 -1.2567 -0.9916 3555859 CMLD3_000055 COC(=O)[C@@H]1[C@H]([C@H]2C(=O)c3c(OC)cc(OC)cc3O[C@@]12c4ccc(OC)cc4)c5ccccc5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 C21 compound treatment 112410.0 -278000.0 -1.39 103720.0 -232000.0 -1.09 -1.7516 -0.9928 831758 CMLD3_000056 Oc1ccc(/C=C/C(=O)c2ccc(O)cc2O)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 C22 compound treatment 435040.0 44800.0 0.22 375000.0 39700.0 0.19 0.2901 0.9959 3555865 CMLD3_000057 COC(=O)N[C@H](C(C(=O)C)C(=O)OC)c1cccc(C)c1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 C23 compound treatment 220480.0 -170000.0 -0.85 359850.0 24500.0 0.12 -0.518 -0.6053 3555869 CMLD3_000058 COC(=O)N[C@H](CC(=O)C)c1ccc(F)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 C24 compound treatment 168070.0 -222000.0 -1.11 313390.0 -21900.0 -0.1 -0.8576 -0.7695 3555873 CMLD3_000059 CCCCCCCC1=CC2=CC(=O)C(C)(O)C(=O)C2=CN1CCCC 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 D01 compound treatment 475650.0 85400.0 0.43 446920.0 112000.0 0.52 0.6728 0.9947 3555876 CMLD3_000060 Cc1ccc(cc1)S(=O)(=O)NC(=O)O[C@H]2[C@@H](Oc3ccc(Br)cc3C2=O)c4ccc5OCOc5c4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 D02 compound treatment 436840.0 46600.0 0.23 415200.0 79900.0 0.38 0.4302 0.9735 3555884 CMLD3_000061 COc1ccc2C(=O)[C@@H](OC(=O)NC3CCCC3)[C@@H](Oc2c1)c4cccc(c4)C(F)(F)F 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 D03 compound treatment 466570.0 76300.0 0.38 427800.0 92500.0 0.43 0.5771 0.9978 3555888 CMLD3_000062 COc1ccc2C(=O)[C@@H](OC(=O)Nc3ccc(C)c(Br)c3)[C@@H](Oc2c1)c4cccc(c4)C(F)(F)F 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 D04 mock treatment 493600.0 103000.0 0.52 410520.0 75200.0 0.35 0.6151 0.983 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 D05 compound treatment 454500.0 64200.0 0.32 447520.0 112000.0 0.53 0.6001 0.9716 3555892 CMLD3_000063 COc1cccc(c1)[C@@H]2Oc3ccc(OC)cc3C[C@H]2OC(=O)N[C@H]4CCCc5ccccc45 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 D06 compound treatment 357030.0 -33200.0 -0.17 445160.0 110000.0 0.52 0.248 0.457 3555896 CMLD3_000064 COC(=O)[C@@H](NC(=O)O[C@H]1[C@@H](Oc2cc(OC)ccc2C1=O)c3ccc4OCOc4c3)C(C)C 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 D07 compound treatment 320410.0 -69800.0 -0.35 255950.0 -79400.0 -0.37 -0.5107 -0.9994 3555901 CMLD3_000065 COc1ccc2C(=O)[C@@H](OC(=O)NC3CCCC3)[C@@H](Oc2c1)c4ccc5OCOc5c4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 D08 mock treatment 223270.0 -167000.0 -0.83 523710.0 188000.0 0.89 0.0368 0.0303 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 D09 compound treatment 529250.0 139000.0 0.69 439720.0 104000.0 0.49 0.8381 0.9856 3555905 CMLD3_000066 COc1cc(NC(=O)O[C@H]2[C@@H](Oc3ccc(Br)cc3C2=O)c4ccc5OCOc5c4)cc(OC)c1OC 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 D10 compound treatment 184750.0 -206000.0 -1.03 206370.0 -129000.0 -0.61 -1.1547 -0.9685 3555908 CMLD3_000067 COc1ccc2O[C@@H]([C@@H](OC(=O)NS(=O)(=O)c3ccc(C)cc3)C(=O)c2c1)c4ccc(OC)c(Br)c4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 D11 mock treatment 539930.0 150000.0 0.75 470920.0 136000.0 0.64 0.9796 0.9969 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 D12 mock treatment 513390.0 123000.0 0.62 466560.0 131000.0 0.62 0.8714 1.0 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 D13 mock treatment 523040.0 133000.0 0.66 180480.0 -155000.0 -0.73 -0.0461 -0.0468 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 D14 compound treatment 213800.0 -176000.0 -0.88 485620.0 150000.0 0.71 -0.1233 -0.1091 3555912 CMLD3_000068 CN(C)c1cccc(O[C@H]2C=C[C@H](O[C@@H]2CO)C#Cc3ccccc3)c1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 D15 mock treatment 373800.0 -16500.0 -0.08 319300.0 -16000.0 -0.08 -0.1114 -0.9991 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 D16 mock treatment 267890.0 -122000.0 -0.61 379970.0 44600.0 0.21 -0.2837 -0.4389 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 D17 compound treatment 486660.0 96400.0 0.48 293920.0 -41400.0 -0.19 0.2028 0.3904 3555916 CMLD3_000069 OC[C@H]1O[C@@H](C=C[C@@H]1Oc2ccc(C=O)cc2)C#Cc3ccccc3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 D18 compound treatment 431230.0 41000.0 0.2 250990.0 -84300.0 -0.4 -0.1358 -0.3042 3555921 CMLD3_000070 COc1ccccc1/C=C/C2=CC3(C)CC2(C)C(CC3=O)c4ccccc4OC 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 D19 compound treatment 13340.0 -377000.0 -1.88 13160.0 -322000.0 -1.52 -2.4026 -0.9942 3555925 CMLD3_000071 CCC/C=C/C1C(CO)C2(OCC(CC)(CC)CO2)[C@@H]3O[C@@H]3C1=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 D20 compound treatment 370250.0 -20000.0 -0.1 399330.0 64000.0 0.3 0.1422 0.4484 3555929 CMLD3_000072 COc1ccc(/C=C/N(CCc2ccc(OC)c(OC)c2)C(=O)C(F)(F)F)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 D21 compound treatment 493450.0 103000.0 0.52 363400.0 28100.0 0.13 0.4578 0.8605 3555933 CMLD3_000073 COc1ccc(cc1)C(=O)CC(=O)c2c(O)cc(OC)cc2OC 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 D22 compound treatment 327810.0 -62400.0 -0.31 351240.0 15900.0 0.07 -0.1676 -0.5225 3555935 CMLD3_000074 COC(=O)N[C@@H](c1ccco1)[C@@]2(CCCC2=O)C(=O)C 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 D23 mock treatment 319730.0 -70500.0 -0.35 398360.0 63000.0 0.3 -0.0394 -0.0856 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 D24 compound treatment 489670.0 99400.0 0.5 435770.0 100000.0 0.47 0.6852 0.9997 3555939 CMLD3_000075 COC(=O)N[C@H](C(C(=O)C)C(=O)OC)c1cccc(F)c1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 E01 mock treatment 476570.0 86300.0 0.43 442360.0 107000.0 0.5 0.6608 0.997 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 E02 mock treatment 534990.0 145000.0 0.72 439280.0 104000.0 0.49 0.8569 0.9819 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 E03 mock treatment 521120.0 131000.0 0.65 376230.0 40900.0 0.19 0.5982 0.878 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 E04 compound treatment 230250.0 -160000.0 -0.8 336030.0 707.0 0.0 -0.5627 -0.7042 3555943 CMLD3_000076 CC[C@H](C)[C@@H](NC(=O)O[C@H]1[C@@H](Oc2cc(OC)ccc2C1=O)c3ccc4OCOc4c3)C(=O)OC 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 E05 compound treatment 354130.0 -36100.0 -0.18 214470.0 -121000.0 -0.57 -0.5295 -0.8879 3555945 CMLD3_000077 COc1cccc(c1)[C@@H]2Oc3ccc(OC)cc3C(=O)[C@H]2OC(=O)NS(=O)(=O)c4ccc(C)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 E06 compound treatment 168720.0 -222000.0 -1.11 216410.0 -119000.0 -0.56 -1.1779 -0.9501 3555948 CMLD3_000078 COc1cccc(c1)[C@@H]2Oc3ccc(OC)cc3C(=O)[C@H]2OC(=O)NS(=O)(=O)c4ccc(F)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 E07 compound treatment 241520.0 -149000.0 -0.74 230890.0 -104000.0 -0.49 -0.8726 -0.9798 3555952 CMLD3_000079 COc1ccc2C(=O)[C@@H](OC(=O)N[C@H](C)C3CCCCC3)[C@@H](Oc2c1)c4ccc5OCOc5c4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 E08 compound treatment 489360.0 99100.0 0.49 357500.0 22200.0 0.1 0.4238 0.8377 3555954 CMLD3_000080 COc1ccc2O[C@@H]([C@@H](OC(=O)NCc3ccc4OCOc4c3)C(=O)c2c1)c5ccc(OC)c(Br)c5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 E09 mock treatment 507470.0 117000.0 0.59 233090.0 -102000.0 -0.48 0.0739 0.0976 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 E10 mock treatment 474980.0 84700.0 0.42 442690.0 107000.0 0.51 0.6563 0.9961 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 E11 compound treatment 171860.0 -218000.0 -1.09 202530.0 -133000.0 -0.62 -1.213 -0.965 3555958 CMLD3_000081 Brc1ccc2O[C@H]([C@H](OC(=O)NCc3ccco3)C(=O)c2c1)c4ccc5OCOc5c4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 E12 compound treatment 270020.0 -120000.0 -0.6 351550.0 16200.0 0.08 -0.3707 -0.6123 3555962 CMLD3_000082 CC[C@H](C)[C@@H](NC(=O)O[C@@H]1[C@H](Oc2cc(OC)ccc2C1=O)c3ccc4OCOc4c3)C(=O)OC 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 E13 compound treatment 414720.0 24500.0 0.12 434610.0 99300.0 0.47 0.4166 0.8631 3555964 CMLD3_000083 COc1cccc(c1)[C@@H]2Oc3ccc(Br)cc3C[C@H]2OC(=O)N[C@H]4CCCc5ccccc45 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 E14 compound treatment 386050.0 -4200.0 -0.02 338810.0 3490.0 0.02 -0.0032 -0.122 3555968 CMLD3_000084 CCOC(=O)OC[C@H]1O[C@H](CCc2ccccc2)CC[C@@H]1Oc3ccc(OC)cc3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 E15 compound treatment 176480.0 -214000.0 -1.07 195330.0 -140000.0 -0.66 -1.2206 -0.973 3555972 CMLD3_000085 CC(C)(C)c1ccc(O[C@H]2C=C[C@H](O[C@@H]2CO)C#Cc3ccccc3)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 E16 compound treatment 167720.0 -223000.0 -1.11 262190.0 -73100.0 -0.34 -1.0292 -0.8846 3555975 CMLD3_000086 CC(C)(C)c1ccc(O[C@@H]2[C@H](O)CO[C@@H]2/C=C/C#Cc3ccccc3)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 E17 mock treatment 494910.0 105000.0 0.52 356220.0 20900.0 0.1 0.4391 0.8256 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 E18 mock treatment 576800.0 187000.0 0.93 444880.0 110000.0 0.52 1.0232 0.961 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 E19 compound treatment 384380.0 -5870.0 -0.03 481950.0 147000.0 0.69 0.4669 0.6764 3555978 CMLD3_000087 C[C@H](O)CCCCCCC/C=C/C=C/C(=O)N 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 E20 compound treatment 241680.0 -149000.0 -0.74 422410.0 87100.0 0.41 -0.2351 -0.2773 3555982 CMLD3_000088 CC1(C)O[C@H]([C@@H](O1)C(O)(c2cccc3c4ccccc4oc23)c5cccc6c7ccccc7oc56)C(O)(c8cccc9c%10ccccc%10oc89)c%11cccc%12c%13ccccc%13oc%11%12 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 E21 mock treatment 370010.0 -20200.0 -0.1 388560.0 53200.0 0.25 0.1056 0.3909 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 E22 compound treatment 390630.0 376.0 0.0 450760.0 115000.0 0.54 0.3853 0.7095 3555987 CMLD3_000089 COC(=O)N[C@@H](c1cccc(C)c1)[C@@]2(CCCC2=O)C(=O)C 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 E23 compound treatment 329710.0 -60500.0 -0.3 357290.0 22000.0 0.1 -0.1408 -0.4405 3555990 CMLD3_000090 CC1(CC2(C)C(CC1=O)c3ccc(cc3)C(F)(F)F)C=C2/C=C/c4ccc(cc4)C(F)(F)F 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 E24 mock treatment 454830.0 64600.0 0.32 486180.0 151000.0 0.71 0.7298 0.9363 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 F01 mock treatment 506660.0 116000.0 0.58 339140.0 3820.0 0.02 0.4238 0.7286 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 F02 mock treatment 460480.0 70200.0 0.35 481980.0 147000.0 0.69 0.7358 0.9508 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 F03 compound treatment 480510.0 90300.0 0.45 479110.0 144000.0 0.68 0.797 0.9806 3555993 CMLD3_000091 CC[C@H](C)[C@@H](NC(=O)O[C@H]1[C@@H](Oc2ccc(Br)cc2C1=O)c3cccc(OC)c3)C(=O)OC 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 F04 compound treatment 488480.0 98200.0 0.49 368570.0 33200.0 0.16 0.4575 0.8885 3555995 CMLD3_000092 COc1cccc(c1)[C@@H]2Oc3ccc(Br)cc3C(=O)[C@H]2OC(=O)N[C@H]4CCCc5ccccc45 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 F05 compound treatment 495750.0 105000.0 0.53 162980.0 -172000.0 -0.81 -0.2006 -0.2075 3555997 CMLD3_000093 COc1cccc(c1)[C@@H]2Oc3ccc(Br)cc3C(=O)[C@H]2OC(=O)NS(=O)(=O)c4ccc(C)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 F06 mock treatment 219110.0 -171000.0 -0.85 209360.0 -126000.0 -0.59 -1.0234 -0.984 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 F07 compound treatment 504130.0 114000.0 0.57 511720.0 176000.0 0.83 0.9889 0.983 3555999 CMLD3_000094 COC(=O)[C@H](Cc1ccccc1)NC(=O)O[C@H]2[C@@H](Oc3cc(OC)ccc3C2=O)c4ccc5OCOc5c4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 F08 compound treatment 255210.0 -135000.0 -0.67 378750.0 43400.0 0.2 -0.3325 -0.4718 3556000 CMLD3_000095 COc1ccc2O[C@@H]([C@@H](OC(=O)N[C@H]3CCCc4ccccc34)C(=O)c2c1)c5ccc(OC)c(Br)c5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 F09 mock treatment 199950.0 -190000.0 -0.95 333310.0 -2010.0 -0.01 -0.6788 -0.7141 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 F10 mock treatment 209450.0 -181000.0 -0.9 210560.0 -125000.0 -0.59 -1.0535 -0.9782 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 F11 mock treatment 349130.0 -41100.0 -0.21 540710.0 205000.0 0.97 0.5379 0.5446 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 F12 compound treatment 193680.0 -197000.0 -0.98 137310.0 -198000.0 -0.93 -1.3528 -0.9997 3556002 CMLD3_000096 COc1cccc(c1)[C@@H]2Oc3ccc(Br)cc3C(=O)[C@H]2OC(=O)NCc4ccco4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 F13 compound treatment 164960.0 -225000.0 -1.13 235620.0 -99700.0 -0.47 -1.1273 -0.9247 3556004 CMLD3_000097 CC[C@H](C)[C@@H](NC(=O)O[C@@H]1[C@H](Oc2ccc(OC)cc2C1=O)c3ccc(OC)c(Br)c3)C(=O)OC 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 F14 compound treatment 70840.0 -319000.0 -1.6 94410.0 -241000.0 -1.13 -1.9293 -0.986 3556006 CMLD3_000098 CCOC(=O)OC[C@H]1O[C@@H](C=C[C@@H]1OC(=O)OCC)C#Cc2ccc(Br)cc2 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 F15 compound treatment 208930.0 -181000.0 -0.91 177600.0 -158000.0 -0.74 -1.165 -0.9951 3556008 CMLD3_000099 COc1ccc(O[C@H]2C=C[C@H](O[C@@H]2CO)C#Cc3ccc(F)cc3F)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 F16 compound treatment 217650.0 -173000.0 -0.86 489290.0 154000.0 0.72 -0.0975 -0.0866 3556010 CMLD3_000100 COc1ccc(O[C@@H]2[C@H](O)CO[C@H]2/C=C/C#Cc3ccc(F)cc3F)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 F17 mock treatment 323320.0 -66900.0 -0.33 305230.0 -30100.0 -0.14 -0.3365 -0.9268 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 F18 mock treatment 541800.0 152000.0 0.76 485160.0 150000.0 0.7 1.0336 0.9994 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 F19 compound treatment 230910.0 -159000.0 -0.8 358210.0 22900.0 0.11 -0.4866 -0.6059 3556012 CMLD3_000101 COc1ccccc1/C=C/C(O)C(=C)C 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 F20 compound treatment 329930.0 -60300.0 -0.3 365930.0 30600.0 0.14 -0.1112 -0.3332 3556014 CMLD3_000102 COCn1c2ccccc2c3nnc(nc13)C(=O)OC(C)C#C 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 F21 compound treatment 176770.0 -213000.0 -1.07 204290.0 -131000.0 -0.62 -1.1898 -0.9661 3556015 CMLD3_000103 CCCCCCC1=Cc2cc(OC)c(OC)cc2C(O1)C3(CCCC3=O)C(=O)OCC 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 F22 compound treatment 203800.0 -186000.0 -0.93 260730.0 -74600.0 -0.35 -0.9066 -0.911 1952239 CMLD3_000104 O=C1/C(=C/c2ccccc2)/Oc3ccccc13 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 F23 compound treatment 319220.0 -71000.0 -0.35 411570.0 76200.0 0.36 0.0027 0.0054 3556016 CMLD3_000105 Cc1c2OCOc2ccc1O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 F24 compound treatment 482360.0 92100.0 0.46 207970.0 -127000.0 -0.6 -0.0983 -0.1301 3556017 CMLD3_000106 COC(=O)N[C@H](C(C(=O)C)C(=O)OC)c1ccc2ccccc2c1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 G01 compound treatment 510330.0 120000.0 0.6 526850.0 192000.0 0.9 1.0611 0.9805 3556019 CMLD3_000107 COc1ccc2O[C@H]([C@H](OC(=O)Nc3cc(OC)c(OC)c(OC)c3)C(=O)c2c1)c4ccc(OC)c(Br)c4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 G02 mock treatment 564070.0 174000.0 0.87 275120.0 -60200.0 -0.28 0.4136 0.453 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 G03 mock treatment 411970.0 21700.0 0.11 236590.0 -98700.0 -0.46 -0.2517 -0.5278 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 G04 mock treatment 530300.0 140000.0 0.7 233220.0 -102000.0 -0.48 0.155 0.1827 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 G05 compound treatment 361820.0 -28400.0 -0.14 292500.0 -42800.0 -0.2 -0.2428 -0.9854 3556020 CMLD3_000108 COc1ccc2C(=O)[C@@H](OC(=O)Nc3ccc(C)c(Br)c3)[C@@H](Oc2c1)c4ccc5OCOc5c4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 G06 compound treatment 204960.0 -185000.0 -0.93 481210.0 146000.0 0.69 -0.1692 -0.1468 3556022 CMLD3_000109 COc1cccc(c1)[C@@H]2Oc3ccc(Br)cc3C(=O)[C@H]2OC(=O)N[C@H](C)C4CCCCC4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 G07 compound treatment 439650.0 49400.0 0.25 218980.0 -116000.0 -0.55 -0.2125 -0.354 3556024 CMLD3_000110 CCOC(=O)CNC(=O)O[C@H]1[C@@H](Oc2cc(OC)ccc2C1=O)c3ccc4OCOc4c3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 G08 mock treatment 530500.0 140000.0 0.7 501460.0 166000.0 0.78 1.0479 0.9985 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 G09 compound treatment 522410.0 132000.0 0.66 346250.0 10900.0 0.05 0.5031 0.7599 3556025 CMLD3_000111 COC(=O)[C@H](COC(C)(C)C)NC(=O)O[C@H]1[C@@H](Oc2ccc(Br)cc2C1=O)c3ccc4OCOc4c3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 G10 compound treatment 495580.0 105000.0 0.53 299620.0 -35700.0 -0.17 0.2532 0.4586 3556027 CMLD3_000112 COc1ccc2C(=O)[C@@H](OC(=O)Nc3ccc(OC(F)F)cc3)[C@@H](Oc2c1)c4cccc(c4)C(F)(F)F 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 G11 mock treatment 357960.0 -32300.0 -0.16 389250.0 53900.0 0.25 0.0653 0.2173 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 G12 compound treatment 509120.0 119000.0 0.59 273120.0 -62200.0 -0.29 0.2129 0.3217 3556029 CMLD3_000113 COc1cccc(c1)[C@@H]2Oc3ccc(OC)cc3C[C@H]2OC(=O)Nc4ccc(OC(F)F)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 G13 compound treatment 261640.0 -129000.0 -0.64 257920.0 -77400.0 -0.36 -0.7117 -0.9638 3556031 CMLD3_000114 CC[C@H](C)[C@@H](NC(=O)O[C@@H]1Cc2cc(OC)ccc2O[C@H]1c3cccc(OC)c3)C(=O)OC 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 G14 compound treatment 380260.0 -9990.0 -0.05 231520.0 -104000.0 -0.49 -0.3805 -0.7754 3556033 CMLD3_000115 COc1ccc(O[C@H]2C=C[C@H](O[C@@H]2CO)C#Cc3ccc(Br)cc3)c(c1)C(C)(C)C 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 G15 compound treatment 176250.0 -214000.0 -1.07 290820.0 -44500.0 -0.21 -0.9038 -0.8298 3556035 CMLD3_000116 COc1ccc(O[C@H]2C=C[C@H](O[C@@H]2CO)C#Cc3ccc(cc3)C(C)(C)C)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 G16 compound treatment 174560.0 -216000.0 -1.08 242190.0 -93100.0 -0.44 -1.0715 -0.9214 3556037 CMLD3_000117 COc1ccc(O[C@@H]2[C@H](O)CO[C@@H]2/C=C/C#Cc3ccc(F)cc3F)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 G17 mock treatment 275810.0 -114000.0 -0.57 339850.0 4530.0 0.02 -0.3891 -0.6803 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 G18 compound treatment 136930.0 -253000.0 -1.27 101970.0 -233000.0 -1.1 -1.6708 -0.9975 3556038 CMLD3_000118 CC(=C)C(O)/C=C/C=C/c1ccccc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 G19 mock treatment 250310.0 -140000.0 -0.7 292120.0 -43200.0 -0.2 -0.6379 -0.8764 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 G20 mock treatment 482910.0 92700.0 0.46 425960.0 90600.0 0.43 0.6287 0.9992 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 G21 compound treatment 311840.0 -78400.0 -0.39 194840.0 -140000.0 -0.66 -0.7442 -0.9688 3556040 CMLD3_000119 COC(=O)N[C@H](CC(=O)C)c1ccc(Cl)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 G22 compound treatment 370560.0 -19700.0 -0.1 236090.0 -99200.0 -0.47 -0.3996 -0.8377 3556042 CMLD3_000120 CCCCCCCC1=CC2=CC(=O)C(C)(OC(=O)C)C(=O)C2=CN1CCc3ccccc3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 G23 compound treatment 465230.0 75000.0 0.37 348570.0 13200.0 0.06 0.3088 0.8136 3556043 CMLD3_000121 CCCCCCC(=O)Cc1cc(OC)c(OC)cc1C=C(C(=O)OCC)C(=O)OCC 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 G24 compound treatment 478560.0 88300.0 0.44 189080.0 -146000.0 -0.69 -0.1745 -0.2136 3556044 CMLD3_000122 CCCCCCC(=O)Cc1cc(OC)c(OC)cc1/C=C(/C(=O)C)\C(=O)OC 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 H01 compound treatment 461410.0 71200.0 0.36 158950.0 -176000.0 -0.83 -0.3353 -0.3715 3556046 CMLD3_000123 COc1cccc(c1)[C@@H]2Oc3ccc(Br)cc3C(=O)[C@H]2OC(=O)Nc4cc(OC)c(OC)c(OC)c4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 H02 compound treatment 217040.0 -173000.0 -0.87 461410.0 126000.0 0.59 -0.1924 -0.1834 3556048 CMLD3_000124 COc1cccc(c1)[C@@H]2Oc3ccc(Br)cc3C[C@H]2OC(=O)Nc4cc(OC)c(OC)c(OC)c4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 H03 mock treatment 196570.0 -194000.0 -0.97 155260.0 -180000.0 -0.85 -1.2829 -0.9978 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 H04 mock treatment 236370.0 -154000.0 -0.77 168220.0 -167000.0 -0.79 -1.0992 -0.9999 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 H05 compound treatment 358080.0 -32200.0 -0.16 232000.0 -103000.0 -0.49 -0.4573 -0.8933 3556050 CMLD3_000125 COc1ccc2C(=O)[C@@H](OC(=O)N[C@H](C)C3CCCCC3)[C@@H](Oc2c1)c4cccc(c4)C(F)(F)F 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 H06 compound treatment 453500.0 63200.0 0.32 429280.0 94000.0 0.44 0.5359 0.9864 3556052 CMLD3_000126 COC(=O)[C@@H](NC(=O)O[C@@H]1[C@H](Oc2ccc(OC)cc2C1=O)c3ccc(OC)c(Br)c3)C(C)C 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 H07 compound treatment 168280.0 -222000.0 -1.11 183680.0 -152000.0 -0.71 -1.2883 -0.9773 3556054 CMLD3_000127 COc1ccc2C(=O)[C@@H](OC(=O)NCc3ccco3)[C@@H](Oc2c1)c4ccc5OCOc5c4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 H08 compound treatment 245050.0 -145000.0 -0.73 324480.0 -10800.0 -0.05 -0.5489 -0.755 3556056 CMLD3_000128 COC(=O)[C@H](Cc1ccccc1)NC(=O)O[C@H]2[C@@H](Oc3ccc(Br)cc3C2=O)c4ccc5OCOc5c4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 H09 compound treatment 178160.0 -212000.0 -1.06 174190.0 -161000.0 -0.76 -1.285 -0.9865 3556058 CMLD3_000129 Brc1ccc2O[C@H]([C@H](OC(=O)NCCOc3ccccc3)C(=O)c2c1)c4ccc5OCOc5c4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 H10 compound treatment 140030.0 -250000.0 -1.25 200350.0 -135000.0 -0.63 -1.3326 -0.9507 3556060 CMLD3_000130 Fc1ccc(cc1)S(=O)(=O)NC(=O)O[C@H]2[C@@H](Oc3ccc(Br)cc3C2=O)c4ccc5OCOc5c4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 H11 compound treatment 509700.0 119000.0 0.6 180890.0 -154000.0 -0.73 -0.0918 -0.0977 3556062 CMLD3_000131 COc1ccc2C(=O)[C@@H](OC(=O)NS(=O)(=O)c3ccc(F)cc3)[C@@H](Oc2c1)c4cccc(c4)C(F)(F)F 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 H12 compound treatment 192380.0 -198000.0 -0.99 355540.0 20200.0 0.1 -0.6316 -0.6361 3556064 CMLD3_000132 COc1ccc2C(=O)[C@H](OC(=O)Nc3ccc(OC(F)F)cc3)[C@H](Oc2c1)c4ccc5OCOc5c4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 H13 mock treatment 225970.0 -164000.0 -0.82 509020.0 174000.0 0.82 -0.0025 -0.0021 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 H14 compound treatment 24550.0 -366000.0 -1.83 23360.0 -312000.0 -1.47 -2.3291 -0.9941 3556065 CMLD3_000133 CC(=O)OC[C@H]1O[C@@H](C=C[C@@H]1OC(=O)C)C#Cc2ccc(cc2)C(C)(C)C 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 H15 compound treatment 330760.0 -59500.0 -0.3 230510.0 -105000.0 -0.49 -0.5587 -0.9706 3556067 CMLD3_000134 Cc1cc(C)cc(C#C[C@H]2O[C@H](CO)[C@@H](Oc3ccc(cc3)C4CCCC4)C=C2)c1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 H16 compound treatment 273620.0 -117000.0 -0.58 313990.0 -21300.0 -0.1 -0.4829 -0.8169 3556069 CMLD3_000135 Cc1ccc(O[C@@H]2[C@H](O)CO[C@H]2/C=C/C#Cc3ccc(cc3)C(C)(C)C)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 H17 compound treatment 261630.0 -129000.0 -0.64 278970.0 -56400.0 -0.27 -0.6417 -0.9234 3556071 CMLD3_000136 CC(=O)c1ccc(cc1)[C@H]2O[C@H](CO)[C@@H](Oc3ccc(F)cc3C)C=C2 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 H18 compound treatment 538990.0 149000.0 0.74 444330.0 109000.0 0.51 0.8878 0.9836 3556073 CMLD3_000137 Clc1cc2nc3-c4ccccc4OC(CC=C)(c5ccccc5)c3nc2cc1Cl 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 H19 mock treatment 520690.0 130000.0 0.65 356710.0 21400.0 0.1 0.5318 0.8067 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 H20 mock treatment 456290.0 66000.0 0.33 360370.0 25000.0 0.12 0.3165 0.9038 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 H21 compound treatment 15250.0 -375000.0 -1.87 11210.0 -324000.0 -1.52 -2.4024 -0.9948 3556074 CMLD3_000138 CCCc1cc2C(=O)[C@H]3O[C@H]3[C@H](O)c2c(=O)o1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 H22 compound treatment 395380.0 5130.0 0.03 226450.0 -109000.0 -0.51 -0.344 -0.6709 3556076 CMLD3_000139 COC(=O)N[C@H](C(C(=O)C)C(=O)OCC=C)c1ccc2ccccc2c1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 H23 mock treatment 428160.0 37900.0 0.19 407840.0 72500.0 0.34 0.3751 0.9614 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 H24 compound treatment 524250.0 134000.0 0.67 190780.0 -145000.0 -0.68 -0.0075 -0.0079 3556078 CMLD3_000140 COC(=O)N[C@@H](c1cccc(F)c1)[C@@]2(CCCC2=O)C(=O)OC 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 I01 compound treatment 265370.0 -125000.0 -0.62 380000.0 44700.0 0.21 -0.2925 -0.4443 3556080 CMLD3_000141 COc1cccc(c1)[C@@H]2Oc3ccc(OC)cc3C(=O)[C@H]2OC(=O)Nc4cc(OC)c(OC)c(OC)c4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 I02 compound treatment 138750.0 -252000.0 -1.26 164200.0 -171000.0 -0.8 -1.4574 -0.9769 3556082 CMLD3_000142 COc1ccc2C(=O)[C@@H](OC(=O)NCc3ccco3)[C@@H](Oc2c1)c4cccc(c4)C(F)(F)F 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 I03 compound treatment 475870.0 85600.0 0.43 137490.0 -198000.0 -0.93 -0.3556 -0.3473 3555962 CMLD3_000143 CC[C@H](C)[C@@H](NC(=O)O[C@@H]1[C@H](Oc2cc(OC)ccc2C1=O)c3ccc4OCOc4c3)C(=O)OC 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 I04 mock treatment 185830.0 -204000.0 -1.02 242930.0 -92400.0 -0.43 -1.0293 -0.9276 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 I05 mock treatment 527330.0 137000.0 0.68 528530.0 193000.0 0.91 1.1267 0.9902 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 I06 mock treatment 488720.0 98500.0 0.49 390750.0 55400.0 0.26 0.5321 0.9559 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 I07 compound treatment 255240.0 -135000.0 -0.67 173760.0 -162000.0 -0.76 -1.0142 -0.9982 3556084 CMLD3_000144 COc1ccc2C(=O)[C@@H](OC(=O)NCc3ccc4OCOc4c3)[C@@H](Oc2c1)c5ccc6OCOc6c5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 I08 compound treatment 285410.0 -105000.0 -0.52 219170.0 -116000.0 -0.55 -0.7566 -0.9998 3556086 CMLD3_000145 Brc1ccc2O[C@H]([C@H](OC(=O)NC3CCCC3)C(=O)c2c1)c4ccc5OCOc5c4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 I09 compound treatment 477990.0 87700.0 0.44 256110.0 -79200.0 -0.37 0.0464 0.0807 3556088 CMLD3_000146 CC[C@H](C)[C@@H](NC(=O)O[C@H]1[C@@H](Oc2ccc(Br)cc2C1=O)c3ccc4OCOc4c3)C(=O)OC 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 I10 compound treatment 305890.0 -84400.0 -0.42 207000.0 -128000.0 -0.6 -0.7247 -0.9846 3556090 CMLD3_000147 CC[C@H](C)[C@@H](NC(=O)O[C@@H]1Cc2cc(Br)ccc2O[C@H]1c3cccc(OC)c3)C(=O)OC 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 I11 compound treatment 455070.0 64800.0 0.32 182050.0 -153000.0 -0.72 -0.2809 -0.3554 3556092 CMLD3_000148 COc1cccc(c1)[C@@H]2Oc3ccc(OC)cc3C(=O)[C@H]2OC(=O)NCc4ccco4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 I12 compound treatment 515570.0 125000.0 0.63 340160.0 4840.0 0.02 0.4587 0.7323 3556094 CMLD3_000149 CCOC(=O)CNC(=O)O[C@H]1[C@@H](Oc2ccc(Br)cc2C1=O)c3ccc4OCOc4c3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 I13 compound treatment 83250.0 -307000.0 -1.53 36860.0 -298000.0 -1.4 -2.0769 -0.999 3011535 CMLD3_000150 COCOc1cc(OC)ccc1C(=O)/C=C/c2ccc3OCOc3c2 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 I14 compound treatment 14800.0 -375000.0 -1.88 27560.0 -308000.0 -1.45 -2.3496 -0.9918 3556096 CMLD3_000151 CC(=O)OC[C@H]1O[C@@H](C=C[C@@H]1OC(=O)C)C#Cc2ccc(C)cc2C 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 I15 compound treatment 281280.0 -109000.0 -0.54 268720.0 -66600.0 -0.31 -0.6064 -0.9656 3556098 CMLD3_000152 CCOC(=O)OC[C@H]1O[C@@H](C=C[C@@H]1Oc2ccc(cc2)c3ccccc3)c4ccc(cc4)C(=O)C 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 I16 compound treatment 524600.0 134000.0 0.67 200290.0 -135000.0 -0.64 0.0253 0.0274 3556100 CMLD3_000153 Cc1ccc(O[C@@H]2[C@H](O)CO[C@@H]2/C=C/C#Cc3ccc(cc3)C(C)(C)C)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 I17 compound treatment 227630.0 -163000.0 -0.81 392680.0 57400.0 0.27 -0.3836 -0.4482 3556101 CMLD3_000154 Cc1cc(F)ccc1O[C@H]2C=C[C@@H](CC=C)O[C@@H]2CO 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 I18 compound treatment 307790.0 -82500.0 -0.41 410420.0 75100.0 0.35 -0.0415 -0.0764 3556103 CMLD3_000155 COC(=O)N(CCc1ccc(OC)c(OC)c1)/C=C/c2ccc(OC)cc2 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 I19 compound treatment 239700.0 -151000.0 -0.75 194050.0 -141000.0 -0.66 -1.0016 -0.9981 3556105 CMLD3_000156 CCCCCCC1=Cc2cc(OC)c(OC)cc2C(O1)C(C(=O)C)C(=O)OC 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 I20 compound treatment 404560.0 14300.0 0.07 192010.0 -143000.0 -0.67 -0.4261 -0.6286 3556106 CMLD3_000157 CC(C)(C)OC1C2C3C2C(CC(O)CC=C)C1C3CC(O)CC=C 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 I21 mock treatment 305020.0 -85200.0 -0.43 177130.0 -158000.0 -0.74 -0.8272 -0.9649 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 I22 mock treatment 245280.0 -145000.0 -0.72 273920.0 -61400.0 -0.29 -0.7162 -0.9188 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 I23 compound treatment 258880.0 -131000.0 -0.66 194620.0 -141000.0 -0.66 -0.9319 -1.0 2119115 CMLD3_000158 COc1ccc(/C=C/C(=O)c2ccc(OC)cc2O)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 I24 compound treatment 278330.0 -112000.0 -0.56 271840.0 -63500.0 -0.3 -0.6064 -0.9569 3556107 CMLD3_000159 COC(=O)N[C@H](C(C(=O)C)C(=O)OCC=C)c1ccc(Cl)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 J01 compound treatment 375200.0 -15100.0 -0.08 137880.0 -197000.0 -0.93 -0.7099 -0.7619 3556109 CMLD3_000160 COc1cccc(c1)[C@@H]2Oc3ccc(Br)cc3C[C@H]2OC(=O)NS(=O)(=O)c4ccc(F)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 J02 compound treatment 322310.0 -67900.0 -0.34 101410.0 -234000.0 -1.1 -1.0179 -0.8841 3556112 CMLD3_000161 CCOC(=O)CNC(=O)O[C@@H]1[C@H](Oc2ccc(OC)cc2C1=O)c3ccc(OC)c(Br)c3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 J03 compound treatment 205000.0 -185000.0 -0.93 267810.0 -67500.0 -0.32 -0.8788 -0.8984 3556115 CMLD3_000162 COC(=O)[C@H](Cc1ccccc1)NC(=O)O[C@H]2[C@@H](Oc3ccc(Br)cc3C2=O)c4cccc(OC)c4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 J04 mock treatment 492290.0 102000.0 0.51 163010.0 -172000.0 -0.81 -0.2128 -0.2222 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 J05 mock treatment 445290.0 55000.0 0.27 208960.0 -126000.0 -0.59 -0.2259 -0.345 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 J06 mock treatment 558240.0 168000.0 0.84 159760.0 -176000.0 -0.83 0.0093 0.0079 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 J07 compound treatment 327780.0 -62500.0 -0.31 137820.0 -198000.0 -0.93 -0.8775 -0.8954 3556117 CMLD3_000163 COc1cccc(c1)[C@@H]2Oc3ccc(OC)cc3C(=O)[C@H]2OC(=O)NCCOc4ccccc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 J08 compound treatment 220340.0 -170000.0 -0.85 490600.0 155000.0 0.73 -0.0836 -0.0747 3556119 CMLD3_000164 COC(=O)[C@@H](NC(=O)O[C@H]1[C@@H](Oc2ccc(Br)cc2C1=O)c3ccc4OCOc4c3)C(C)C 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 J09 compound treatment 524180.0 134000.0 0.67 449280.0 114000.0 0.54 0.852 0.994 3556123 CMLD3_000165 CC[C@H](C)[C@@H](NC(=O)O[C@H]1[C@@H](Oc2ccc(OC)cc2C1=O)c3ccc(OC)c(Br)c3)C(=O)OC 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 J10 compound treatment 283210.0 -107000.0 -0.53 139520.0 -196000.0 -0.92 -1.0293 -0.9665 3556129 CMLD3_000166 COc1ccc2O[C@H]([C@H](OC(=O)NS(=O)(=O)c3ccc(F)cc3)C(=O)c2c1)c4ccc(OC)c(Br)c4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 J11 compound treatment 169680.0 -221000.0 -1.1 133410.0 -202000.0 -0.95 -1.4506 -0.9973 3556130 CMLD3_000167 COc1ccc2O[C@@H]([C@@H](OC(=O)NCc3ccco3)C(=O)c2c1)c4ccc(OC)c(Br)c4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 J12 compound treatment 228800.0 -161000.0 -0.81 169820.0 -166000.0 -0.78 -1.1207 -0.9998 3556132 CMLD3_000168 COc1cccc(c1)[C@@H]2Oc3ccc(OC)cc3C(=O)[C@H]2OC(=O)NCc4ccc5OCOc5c4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 J13 compound treatment 9600.0 -381000.0 -1.9 5330.0 -330000.0 -1.55 -2.4419 -0.9949 3556134 CMLD3_000169 COCOc1ccc(OC)cc1C(=O)/C=C/c2ccc(OC)c(Br)c2 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 J14 compound treatment 72600.0 -318000.0 -1.59 24560.0 -311000.0 -1.46 -2.1554 -0.9992 3556136 CMLD3_000170 CC(=O)OC[C@H]1O[C@@H](C=C[C@@H]1OC(=O)C)C#Cc2ccc(F)cc2F 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 J15 compound treatment 183420.0 -207000.0 -1.03 168520.0 -167000.0 -0.78 -1.2853 -0.9908 3556138 CMLD3_000171 CCOC(=O)OC[C@H]1O[C@@H]([C@@H](C=C1)c2cc(ccc2O)c3ccccc3)c4ccc(cc4)C(=O)C 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 J16 mock treatment 572910.0 183000.0 0.91 255690.0 -79600.0 -0.37 0.3802 0.3855 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 J17 compound treatment 15150.0 -375000.0 -1.87 17190.0 -318000.0 -1.5 -2.3828 -0.9938 3556140 CMLD3_000172 COC(=O)C1(CC(=CCc2ccccc2C1C[N+](=O)[O-])C=C)C(=O)OC 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 J18 mock treatment 503520.0 113000.0 0.57 304960.0 -30400.0 -0.14 0.299 0.5125 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 J19 compound treatment 374480.0 -15800.0 -0.08 301880.0 -33400.0 -0.16 -0.1669 -0.9489 3556141 CMLD3_000173 COc1cccc(/C=C/C(O)C(=C)C)c1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 J20 compound treatment 481000.0 90700.0 0.45 261310.0 -74000.0 -0.35 0.0743 0.13 3556143 CMLD3_000174 COC(=O)N1CCc2cc(OC)c(OC)cc2C1Cc3ccc(OC)cc3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 J21 mock treatment 463640.0 73400.0 0.37 237120.0 -98200.0 -0.46 -0.0674 -0.1144 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 J22 mock treatment 358080.0 -32200.0 -0.16 309400.0 -25900.0 -0.12 -0.1998 -0.9907 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 J23 compound treatment 478850.0 88600.0 0.44 350950.0 15600.0 0.07 0.3649 0.8134 3556144 CMLD3_000175 CCOC(=O)[C@]1(CCCC1=O)[C@@H](NC(=O)OC)c2cccc(C)c2 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 J24 compound treatment 302370.0 -87900.0 -0.44 368640.0 33300.0 0.16 -0.1996 -0.4282 3556146 CMLD3_000176 OC[C@@H]1CCCN1C(=O)/C=C/c2ccccc2 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 K01 compound treatment 531840.0 142000.0 0.71 459300.0 124000.0 0.58 0.9124 0.9954 3556148 CMLD3_000177 COc1cccc(c1)[C@@H]2Oc3ccc(Br)cc3C(=O)[C@H]2OC(=O)NC4CCCC4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 K02 compound treatment 500260.0 110000.0 0.55 148380.0 -187000.0 -0.88 -0.2333 -0.225 3556150 CMLD3_000178 COC(=O)[C@H](COC(C)(C)C)NC(=O)O[C@H]1[C@@H](Oc2cc(OC)ccc2C1=O)c3cccc(c3)C(F)(F)F 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 K03 compound treatment 166560.0 -224000.0 -1.12 457880.0 123000.0 0.58 -0.3824 -0.3042 3556152 CMLD3_000179 COc1ccc2C(=O)[C@@H](OC(=O)NCc3ccc4OCOc4c3)[C@@H](Oc2c1)c5cccc(c5)C(F)(F)F 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 K04 mock treatment 534130.0 144000.0 0.72 214080.0 -121000.0 -0.57 0.1049 0.1143 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 K05 compound treatment 418790.0 28500.0 0.14 314240.0 -21100.0 -0.1 0.0307 0.1766 3011485 CMLD3_000180 COc1ccc2C(=O)[C@@H](O)[C@@H](Oc2c1)c3cccc(c3)C(F)(F)F 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 K06 compound treatment 269710.0 -121000.0 -0.6 221930.0 -113000.0 -0.53 -0.8029 -0.9982 3556154 CMLD3_000181 COc1cccc(c1)[C@@H]2Oc3ccc(OC)cc3C(=O)[C@H]2OC(=O)Nc4ccc(C)c(Br)c4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 K07 mock treatment 296890.0 -93400.0 -0.47 553040.0 218000.0 1.02 0.3944 0.3505 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 K08 mock treatment 181140.0 -209000.0 -1.04 222790.0 -113000.0 -0.53 -1.1128 -0.9504 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 K09 compound treatment 213140.0 -177000.0 -0.88 137390.0 -198000.0 -0.93 -1.2838 -0.9997 3556156 CMLD3_000182 COc1cccc(c1)[C@@H]2Oc3ccc(Br)cc3C(=O)[C@H]2OC(=O)Nc4ccc(OC(F)F)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 K10 compound treatment 148160.0 -242000.0 -1.21 140320.0 -195000.0 -0.92 -1.5036 -0.9907 3556158 CMLD3_000183 COc1ccc2O[C@H]([C@H](OC(=O)NS(=O)(=O)c3ccc(C)cc3)C(=O)c2c1)c4ccc(OC)c(Br)c4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 K11 compound treatment 175250.0 -215000.0 -1.07 184910.0 -150000.0 -0.71 -1.2596 -0.9795 3556159 CMLD3_000184 COc1cccc(c1)[C@@H]2Oc3ccc(Br)cc3C(=O)[C@H]2OC(=O)NCCc4ccc(OC)c(OC)c4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 K12 compound treatment 170800.0 -219000.0 -1.1 172660.0 -163000.0 -0.77 -1.3161 -0.9846 3556161 CMLD3_000185 COc1ccc2O[C@H]([C@H](OC(=O)NCc3ccc4OCOc4c3)C(=O)c2c1)c5ccc(OC)c(Br)c5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 K13 mock treatment 497350.0 107000.0 0.53 237930.0 -97400.0 -0.46 0.0543 0.0771 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 K14 compound treatment 517380.0 127000.0 0.63 222440.0 -113000.0 -0.53 0.0735 0.0888 3556162 CMLD3_000186 CC(=O)OC[C@H]1O[C@@H](C=C[C@@H]1OC(=O)C)c2cc(C)cc(C)c2 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 K15 mock treatment 321120.0 -69100.0 -0.35 432190.0 96900.0 0.46 0.078 0.1365 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 K16 mock treatment 175680.0 -215000.0 -1.07 456800.0 121000.0 0.57 -0.3538 -0.2913 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 K17 compound treatment 228710.0 -162000.0 -0.81 213160.0 -122000.0 -0.57 -0.9768 -0.9862 3556164 CMLD3_000187 COC(=O)N[C@H](CC(=O)C)c1cccc(C)c1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 K18 compound treatment 498720.0 108000.0 0.54 363010.0 27700.0 0.13 0.4752 0.8528 3556166 CMLD3_000188 COC(=O)N[C@H](CC(=O)C)c1ccco1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 K19 compound treatment 206760.0 -183000.0 -0.92 368480.0 33200.0 0.16 -0.5378 -0.5785 3556168 CMLD3_000189 COc1ccc(OC)c(c1)[C@@H]2OCCC=C[C@H]2C 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 K20 compound treatment 359970.0 -30300.0 -0.15 223360.0 -112000.0 -0.53 -0.4793 -0.8748 3556170 CMLD3_000190 CC1=C(C)CC(C(C1)C(=O)c2ccccc2O)c3ccccc3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 K21 mock treatment 544260.0 154000.0 0.77 296200.0 -39100.0 -0.18 0.4138 0.5232 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 K22 compound treatment 382170.0 -8080.0 -0.04 323580.0 -11700.0 -0.06 -0.0676 -0.9881 3556171 CMLD3_000191 CCCCCCC1=Cc2cc(OC)c(OC)cc2C(O1)C(C(=O)C)C(=O)OCC 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 K23 mock treatment 508320.0 118000.0 0.59 273930.0 -61400.0 -0.29 0.2128 0.3241 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 K24 mock treatment 502570.0 112000.0 0.56 220050.0 -115000.0 -0.54 0.0133 0.017 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 L01 mock treatment 426500.0 36200.0 0.18 336880.0 1560.0 0.01 0.1332 0.7351 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 L02 compound treatment 199410.0 -191000.0 -0.95 190160.0 -145000.0 -0.68 -1.1568 -0.9866 3556172 CMLD3_000192 COc1ccc2O[C@H]([C@H](OC(=O)NCc3ccco3)C(=O)c2c1)c4ccc(OC)c(Br)c4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 L03 mock treatment 529480.0 139000.0 0.7 219520.0 -116000.0 -0.54 0.1065 0.1206 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 L04 mock treatment 382170.0 -8080.0 -0.04 315730.0 -19600.0 -0.09 -0.0937 -0.9314 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 L05 compound treatment 420230.0 30000.0 0.15 344830.0 9510.0 0.04 0.1375 0.8799 3556173 CMLD3_000193 O[C@H]1[C@@H](Oc2ccc(Br)cc2C1=O)c3ccc4OCOc4c3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 L06 compound treatment 540230.0 150000.0 0.75 234240.0 -101000.0 -0.48 0.1935 0.2181 3556175 CMLD3_000194 COc1cccc(c1)[C@@H]2Oc3ccc(OC)cc3C(=O)[C@H]2OC(=O)Nc4ccc(OC(F)F)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 L07 mock treatment 520250.0 130000.0 0.65 455750.0 120000.0 0.57 0.8596 0.9977 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 L08 mock treatment 466490.0 76200.0 0.38 184190.0 -151000.0 -0.71 -0.2334 -0.2895 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 L09 compound treatment 324520.0 -65700.0 -0.33 439310.0 104000.0 0.49 0.1137 0.193 3556177 CMLD3_000195 COc1cccc(c1)[C@@H]2Oc3ccc(Br)cc3C(=O)[C@H]2OC(=O)NS(=O)(=O)c4ccc(F)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 L10 compound treatment 278560.0 -112000.0 -0.56 269390.0 -65900.0 -0.31 -0.6138 -0.9616 3556179 CMLD3_000196 COc1cccc(c1)[C@@H]2Oc3ccc(Br)cc3C(=O)[C@H]2OC(=O)Nc4ccc(C)c(Br)c4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 L11 compound treatment 264230.0 -126000.0 -0.63 433700.0 98400.0 0.46 -0.1179 -0.1509 3556181 CMLD3_000197 COC(=O)[C@@H](NC(=O)O[C@@H]1[C@H](Oc2cc(OC)ccc2C1=O)c3ccc4OCOc4c3)C(C)C 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 L12 compound treatment 308720.0 -81500.0 -0.41 280360.0 -55000.0 -0.26 -0.4708 -0.976 3556182 CMLD3_000198 COc1ccc2C(=O)[C@H](OC(=O)NCc3ccc4OCOc4c3)[C@H](Oc2c1)c5ccc6OCOc6c5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 L13 compound treatment 14820.0 -375000.0 -1.88 10400.0 -325000.0 -1.53 -2.4066 -0.9948 3556183 CMLD3_000199 CCCCCCC#C[C@H]1O[C@H](COC(=O)C)[C@@H](OC(=O)C)C=C1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 L14 compound treatment 18630.0 -372000.0 -1.86 17460.0 -318000.0 -1.5 -2.3697 -0.9942 3556185 CMLD3_000200 CCOC(=O)OC[C@H]1O[C@@H](C=C[C@@H]1OC(=O)OCC)C#Cc2ccc(cc2)C(C)(C)C 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 L15 mock treatment 462470.0 72200.0 0.36 198570.0 -137000.0 -0.64 -0.1998 -0.2709 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 L16 mock treatment 281040.0 -109000.0 -0.55 232340.0 -103000.0 -0.48 -0.7282 -0.9982 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 L17 compound treatment 196640.0 -194000.0 -0.97 256250.0 -79100.0 -0.37 -0.9468 -0.9138 3556187 CMLD3_000201 COC(=O)CC1=CO[C@@H](O)[C@H]2[C@@H]1CC=C2CO 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 L18 compound treatment 116510.0 -274000.0 -1.37 117720.0 -218000.0 -1.02 -1.6905 -0.9898 3556189 CMLD3_000202 COC(=O)C1=NOC2(C1)C=C(Br)C(=C(Br)C2=O)OC 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 L19 compound treatment 230450.0 -160000.0 -0.8 338650.0 3330.0 0.02 -0.5533 -0.6931 3556190 CMLD3_000203 O=C1OC(=NC21CC2)C3=CCCCC3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 L20 mock treatment 415680.0 25400.0 0.13 293710.0 -41600.0 -0.2 -0.0486 -0.2083 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 L21 compound treatment 446440.0 56200.0 0.28 394470.0 59100.0 0.28 0.3952 1.0 3556191 CMLD3_000204 CCCCCCC1Cc2cc(OC)c(OC)cc2C(O1)C(C(=O)OCC)C(=O)OCC 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 L22 compound treatment 397120.0 6870.0 0.03 360090.0 24800.0 0.12 0.1066 0.878 3556192 CMLD3_000205 COC(=O)[C@@H](OCc1ccccc1)/C=C/[C@H](C)Cc2cc(Br)cc(OCc3ccccc3)c2OC 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 L23 mock treatment 206910.0 -183000.0 -0.92 436680.0 101000.0 0.48 -0.3104 -0.3007 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 L24 mock treatment 265150.0 -125000.0 -0.62 431310.0 96000.0 0.45 -0.1226 -0.159 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 M01 mock treatment 516660.0 126000.0 0.63 222370.0 -113000.0 -0.53 0.0707 0.0857 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 M02 compound treatment 523320.0 133000.0 0.66 495000.0 160000.0 0.75 1.001 0.9981 3556194 CMLD3_000206 COC(=O)[C@H](COC(C)(C)C)NC(=O)O[C@H]1[C@@H](Oc2ccc(OC)cc2C1=O)c3ccc(OC)c(Br)c3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 M03 compound treatment 546270.0 156000.0 0.78 199120.0 -136000.0 -0.64 0.098 0.0971 3556196 CMLD3_000207 COC(=O)[C@@H](NC(=O)O[C@H]1[C@@H](Oc2ccc(Br)cc2C1=O)c3cccc(OC)c3)C(C)C 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 M04 compound treatment 304080.0 -86200.0 -0.43 471200.0 136000.0 0.64 0.1476 0.1915 3556198 CMLD3_000208 COc1ccc2C(=O)[C@@H](OC(=O)Nc3cc(OC)c(OC)c(OC)c3)[C@@H](Oc2c1)c4ccc5OCOc5c4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 M05 compound treatment 472650.0 82400.0 0.41 218470.0 -117000.0 -0.55 -0.0977 -0.1422 3556199 CMLD3_000209 COc1cccc(c1)[C@@H]2Oc3ccc(Br)cc3C[C@H]2OC(=O)N[C@H](C)C4CCCCC4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 M06 compound treatment 315200.0 -75100.0 -0.37 315040.0 -20300.0 -0.1 -0.3325 -0.8597 3556201 CMLD3_000210 COc1cccc(c1)[C@@H]2Oc3ccc(OC)cc3C(=O)[C@H]2OC(=O)N[C@H](C)C4CCCCC4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 M07 compound treatment 386840.0 -3410.0 -0.02 176960.0 -158000.0 -0.74 -0.5388 -0.7231 3556203 CMLD3_000211 COc1ccc2C(=O)[C@@H](OC(=O)NCCc3ccc(OC)c(OC)c3)[C@@H](Oc2c1)c4ccc5OCOc5c4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 M08 compound treatment 408810.0 18600.0 0.09 326820.0 -8500.0 -0.04 0.0373 0.3691 3556205 CMLD3_000212 COC(=O)[C@H](Cc1ccccc1)NC(=O)O[C@H]2[C@@H](Oc3ccc(OC)cc3C2=O)c4ccc(OC)c(Br)c4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 M09 mock treatment 560490.0 170000.0 0.85 257180.0 -78100.0 -0.37 0.3413 0.3685 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 M10 mock treatment 258310.0 -132000.0 -0.66 417890.0 82600.0 0.39 -0.1914 -0.2502 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 M11 compound treatment 185530.0 -205000.0 -1.02 182080.0 -153000.0 -0.72 -1.2327 -0.9854 3556206 CMLD3_000213 COc1ccc2O[C@@H]([C@@H](OC(=O)NCCc3ccc(OC)c(OC)c3)C(=O)c2c1)c4ccc(OC)c(Br)c4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 M12 compound treatment 381390.0 -8860.0 -0.04 359430.0 24100.0 0.11 0.0489 0.4015 2060493 CMLD3_000214 COc1ccc2c(=O)c(coc2c1)c3ccc4OCOc4c3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 M13 mock treatment 474560.0 84300.0 0.42 476110.0 141000.0 0.66 0.766 0.9761 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 M14 mock treatment 472320.0 82100.0 0.41 248220.0 -87100.0 -0.41 1.0E-4 2.0E-4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 M15 mock treatment 523400.0 133000.0 0.66 250680.0 -84600.0 -0.4 0.1887 0.2435 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 M16 mock treatment 410080.0 19800.0 0.1 530820.0 195000.0 0.92 0.7202 0.7787 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 M17 compound treatment 506760.0 117000.0 0.58 304190.0 -31100.0 -0.15 0.3079 0.5132 3556208 CMLD3_000215 COC(=O)N[C@@H](c1ccccc1)[C@@]2(CCCC2=O)C(=O)C 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 M18 compound treatment 339390.0 -50900.0 -0.25 281050.0 -54300.0 -0.26 -0.3601 -1.0 3556210 CMLD3_000216 COc1ccc(/C=C/NC(=O)Cc2ccc(OC)c(OC)c2)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 M19 compound treatment 376960.0 -13300.0 -0.07 265060.0 -70300.0 -0.33 -0.2806 -0.8325 3556212 CMLD3_000217 CCOP(=O)(CC(C(O)c1ccccc1)C(=O)C)OCC 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 M20 compound treatment 378290.0 -12000.0 -0.06 270140.0 -65200.0 -0.31 -0.2591 -0.8293 3556213 CMLD3_000218 CCOC(=O)[C@]1(CCCC1=O)[C@@H](NC(=O)OC)/C=C/c2ccco2 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 M21 compound treatment 451580.0 61300.0 0.31 433320.0 98000.0 0.46 0.5425 0.9803 3556215 CMLD3_000219 CC1(C)O[C@H]([C@@H](O1)C(O)(c2cc(cc(c2)C(F)(F)F)C(F)(F)F)c3cc(cc(c3)C(F)(F)F)C(F)(F)F)C(O)(c4cc(cc(c4)C(F)(F)F)C(F)(F)F)c5cc(cc(c5)C(F)(F)F)C(F)(F)F 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 M22 compound treatment 243520.0 -147000.0 -0.73 369220.0 33900.0 0.16 -0.4055 -0.5406 3556217 CMLD3_000220 COC(=O)[C@]1(CCCC1=O)[C@@H](NC(=O)O/C=C/C)c2ccccc2 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 M23 compound treatment 283900.0 -106000.0 -0.53 391900.0 56600.0 0.27 -0.1874 -0.3155 3556219 CMLD3_000221 CC1(O)C(=O)C=C2C=C(CCCCOCc3ccccc3)OC=C2C1=O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 M24 compound treatment 224670.0 -166000.0 -0.83 369440.0 34100.0 0.16 -0.4713 -0.5595 3556220 CMLD3_000222 COC(=O)N[C@H](/C(=C(\C)/NCc1ccccc1)/C(=O)OC)c2ccccc2 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 N01 compound treatment 196270.0 -194000.0 -0.97 226720.0 -109000.0 -0.51 -1.0463 -0.9553 3556222 CMLD3_000223 COc1ccc2C(=O)[C@@H](OC(=O)Nc3cc(OC)c(OC)c(OC)c3)[C@@H](Oc2c1)c4cccc(c4)C(F)(F)F 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 N02 mock treatment 305610.0 -84600.0 -0.42 472330.0 137000.0 0.64 0.1567 0.2034 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 N03 compound treatment 396430.0 6180.0 0.03 419100.0 83800.0 0.39 0.3005 0.7601 3556224 CMLD3_000224 COc1ccc2O[C@@H]([C@@H](OC(=O)Nc3ccc(OC(F)F)cc3)C(=O)c2c1)c4ccc(OC)c(Br)c4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 N04 compound treatment 146680.0 -244000.0 -1.22 195210.0 -140000.0 -0.66 -1.3262 -0.9586 3556226 CMLD3_000225 COc1cccc(c1)[C@@H]2Oc3ccc(OC)cc3[C@H](O)[C@H]2O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 N05 compound treatment 205760.0 -184000.0 -0.92 227060.0 -108000.0 -0.51 -1.0117 -0.9609 3556228 CMLD3_000226 COc1ccc2O[C@@H]([C@@H](O)C(=O)c2c1)c3ccc(OC)c(Br)c3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 N06 compound treatment 296360.0 -93900.0 -0.47 365600.0 30300.0 0.14 -0.2309 -0.4711 3556229 CMLD3_000227 COC(=O)[C@H](Cc1ccccc1)NC(=O)O[C@H]2[C@@H](Oc3ccc(OC)cc3C2=O)c4cccc(OC)c4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 N07 compound treatment 181520.0 -209000.0 -1.04 169760.0 -166000.0 -0.78 -1.2878 -0.9897 3556231 CMLD3_000228 COc1cccc(c1)[C@@H]2Oc3ccc(OC)cc3C(=O)[C@H]2OC(=O)NCCc4ccc(OC)c(OC)c4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 N08 compound treatment 192230.0 -198000.0 -0.99 224830.0 -110000.0 -0.52 -1.0669 -0.9549 3556233 CMLD3_000229 COc1cccc(c1)[C@@H]2Oc3ccc(Br)cc3C(=O)[C@H]2OC(=O)NCCOc4ccccc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 N09 mock treatment 211800.0 -178000.0 -0.89 356220.0 20900.0 0.1 -0.5607 -0.6253 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 N10 mock treatment 496900.0 107000.0 0.53 381700.0 46400.0 0.22 0.5309 0.9223 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 N11 mock treatment 255960.0 -134000.0 -0.67 207230.0 -128000.0 -0.6 -0.9003 -0.9986 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 N12 compound treatment 173990.0 -216000.0 -1.08 178130.0 -157000.0 -0.74 -1.2866 -0.9829 3556235 CMLD3_000230 COc1cccc(c1)[C@@H]2Oc3ccc(OC)cc3C[C@H]2OC(=O)NCc4ccco4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 N13 mock treatment 345670.0 -44600.0 -0.22 288570.0 -46800.0 -0.22 -0.313 -1.0 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 N14 mock treatment 276340.0 -114000.0 -0.57 217000.0 -118000.0 -0.56 -0.7958 -0.9999 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 N15 compound treatment 360840.0 -29400.0 -0.15 237200.0 -98100.0 -0.46 -0.4302 -0.8883 3556237 CMLD3_000231 CC(=O)c1ccc(O[C@@H]2[C@H](O)CO[C@@H]2/C=C/c3ccc(Cl)cc3)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 N16 compound treatment 75620.0 -315000.0 -1.57 65360.0 -270000.0 -1.27 -2.0091 -0.9944 3556239 CMLD3_000232 CCCCC#C[C@H]1O[C@H](CO)[C@@H](Oc2ccc(OC)cc2)C=C1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 N17 compound treatment 383490.0 -6760.0 -0.03 373280.0 38000.0 0.18 0.1024 0.5633 3556241 CMLD3_000233 COC(=O)N[C@H](C(C(=O)C)C(=O)OCC=C)c1cccc(c1)C(F)(F)F 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 N18 compound treatment 378580.0 -11700.0 -0.06 323680.0 -11600.0 -0.05 -0.08 -0.9995 3556243 CMLD3_000234 COC(=O)N[C@H](C(C(=O)C)C(=O)OCC=C)c1cccs1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 N19 compound treatment 319760.0 -70500.0 -0.35 188320.0 -147000.0 -0.69 -0.7379 -0.951 3556191 CMLD3_000235 CCCCCCC1Cc2cc(OC)c(OC)cc2C(O1)C(C(=O)OCC)C(=O)OCC 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 N20 compound treatment 352320.0 -37900.0 -0.19 237040.0 -98300.0 -0.46 -0.4609 -0.9224 3556245 CMLD3_000236 COc1ccc(/C=C/N(CCc2ccc(OC)c(OC)c2)C(=O)C)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 N21 mock treatment 423870.0 33600.0 0.17 445920.0 111000.0 0.52 0.4866 0.8901 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 N22 compound treatment 318950.0 -71300.0 -0.36 312980.0 -22300.0 -0.11 -0.3261 -0.8783 3556247 CMLD3_000237 CCC1(CC2(CC)C(CC1=O)c3ccccc3)C=C2/C=C/c4ccccc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 N23 compound treatment 230470.0 -160000.0 -0.8 410830.0 75500.0 0.36 -0.3132 -0.3585 3556249 CMLD3_000238 CC1(CC2(C)C(CC1=O)c3ccc(F)cc3)C=C2/C=C/c4ccc(F)cc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 N24 mock treatment 398500.0 8250.0 0.04 381040.0 45700.0 0.22 0.1812 0.8275 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 O01 compound treatment 240550.0 -150000.0 -0.75 196810.0 -139000.0 -0.65 -0.9894 -0.9976 3556251 CMLD3_000239 COc1ccc2O[C@@H]([C@@H](OC(=O)N[C@H](C)C3CCCCC3)C(=O)c2c1)c4ccc(OC)c(Br)c4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 O02 compound treatment 383960.0 -6290.0 -0.03 471570.0 136000.0 0.64 0.4309 0.6716 3556253 CMLD3_000240 COC(=O)[C@H](COC(C)(C)C)NC(=O)O[C@H]1[C@@H](Oc2cc(OC)ccc2C1=O)c3ccc4OCOc4c3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 O03 compound treatment 471680.0 81400.0 0.41 190080.0 -145000.0 -0.68 -0.1955 -0.2459 3556254 CMLD3_000241 COc1ccc2C(=O)[C@@H](OC(=O)N[C@H]3CCCc4ccccc34)[C@@H](Oc2c1)c5cccc(c5)C(F)(F)F 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 O04 compound treatment 134740.0 -256000.0 -1.28 169060.0 -166000.0 -0.78 -1.4554 -0.9724 3556256 CMLD3_000242 COc1ccc2C(=O)[C@H](OC(=O)Nc3ccc(C)c(Br)c3)[C@H](Oc2c1)c4ccc5OCOc5c4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 O05 compound treatment 156480.0 -234000.0 -1.17 258460.0 -76900.0 -0.36 -1.0813 -0.8846 3131449 CMLD3_000243 COc1cccc(c1)[C@@H]2Oc3ccc(OC)cc3C(=O)[C@H]2O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 O06 compound treatment 172280.0 -218000.0 -1.09 433960.0 98600.0 0.46 -0.4417 -0.3733 3556257 CMLD3_000244 COc1cccc(c1)[C@@H]2Oc3ccc(OC)cc3C(=O)[C@H]2OC(=O)N[C@H]4CCCc5ccccc45 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 O07 mock treatment 253210.0 -137000.0 -0.68 514450.0 179000.0 0.84 0.1118 0.103 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 O08 mock treatment 173300.0 -217000.0 -1.08 337690.0 2370.0 0.01 -0.7583 -0.6998 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 O09 mock treatment 474080.0 83800.0 0.42 372530.0 37200.0 0.18 0.4198 0.9251 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 O10 compound treatment 260450.0 -130000.0 -0.65 450030.0 115000.0 0.54 -0.0769 -0.0912 3556259 CMLD3_000245 COc1cccc(c1)[C@@H]2Oc3ccc(OC)cc3C[C@H]2O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 O11 mock treatment 379420.0 -10800.0 -0.05 349990.0 14700.0 0.07 0.0105 0.12 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 O12 mock treatment 565760.0 176000.0 0.88 509290.0 174000.0 0.82 1.1984 0.9994 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 O13 compound treatment 27840.0 -362000.0 -1.81 28520.0 -307000.0 -1.44 -2.3003 -0.9937 3556261 CMLD3_000246 CCOC(=O)OC[C@H]1O[C@@H](C=C[C@@H]1OC(=O)OCC)C#Cc2ccccc2 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 O14 compound treatment 16030.0 -374000.0 -1.87 18210.0 -317000.0 -1.49 -2.3763 -0.9938 3556263 CMLD3_000247 CCOC(=O)OC[C@H]1O[C@@H](C=C[C@@H]1OC(=O)OCC)C#Cc2ccc(C)cc2C 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 O15 compound treatment 472650.0 82400.0 0.41 496480.0 161000.0 0.76 0.827 0.9588 3556265 CMLD3_000248 CC(=O)c1ccc(O[C@@H]2[C@H](O)CO[C@H]2/C=C/c3ccc(Cl)cc3)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 O16 compound treatment 91530.0 -299000.0 -1.49 83450.0 -252000.0 -1.18 -1.8927 -0.9935 3556008 CMLD3_000249 COc1ccc(O[C@H]2C=C[C@H](O[C@@H]2CO)C#Cc3ccc(F)cc3F)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 O17 compound treatment 453840.0 63600.0 0.32 251580.0 -83700.0 -0.39 -0.054 -0.1067 3556266 CMLD3_000250 CC(=CCC1(CC=C(C)C)C(=O)C(=C2OC(C)(C)CCC2(CC=C(C)C)C1=O)C(=O)c3ccccc3)C 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 O18 compound treatment 241940.0 -148000.0 -0.74 240510.0 -94800.0 -0.45 -0.8391 -0.9705 3556267 CMLD3_000251 CC1(CC2(C)C(CC1=O)/C=C/c3ccccc3)C=C2/C=C/C=C/c4ccccc4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 O19 compound treatment 343880.0 -46400.0 -0.23 267150.0 -68200.0 -0.32 -0.3905 -0.9872 1125649 CMLD3_000252 CNc1ccccc1C(=O)OCC(=O)c2ccccc2 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 O20 mock treatment 296260.0 -94000.0 -0.47 357940.0 22600.0 0.11 -0.2567 -0.5333 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 O21 mock treatment 340420.0 -49800.0 -0.25 396100.0 60800.0 0.29 0.0261 0.069 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 O22 compound treatment 495620.0 105000.0 0.53 372840.0 37500.0 0.18 0.4969 0.8952 3556269 CMLD3_000253 CNc1ccccc1C(=O)OCC(=O)C 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 O23 compound treatment 245440.0 -145000.0 -0.72 373170.0 37800.0 0.18 -0.3856 -0.5176 3556270 CMLD3_000254 COc1ccc(/C=C/NC(=O)c2ccc(OC)cc2)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 O24 compound treatment 499400.0 109000.0 0.55 399270.0 63900.0 0.3 0.5982 0.9607 3556272 CMLD3_000255 COC(=O)N[C@H](/C(=C(\C)/NCc1ccccc1)/C(=O)OC)c2ccc(Cl)cc2 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 P01 compound treatment 198720.0 -192000.0 -0.96 171440.0 -164000.0 -0.77 -1.2215 -0.9943 3556274 CMLD3_000256 COC(=O)[C@@H](NC(=O)O[C@H]1[C@@H](Oc2cc(OC)ccc2C1=O)c3cccc(c3)C(F)(F)F)C(C)C 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 P02 mock treatment 437280.0 47000.0 0.23 430560.0 95200.0 0.45 0.4828 0.9546 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 P03 mock treatment 497020.0 107000.0 0.53 219550.0 -116000.0 -0.54 -0.008 -0.0105 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 P04 compound treatment 351360.0 -38900.0 -0.19 323520.0 -11800.0 -0.06 -0.1766 -0.8742 3556276 CMLD3_000257 COc1ccc2O[C@@H]([C@@H](OC(=O)Nc3ccc(C)c(Br)c3)C(=O)c2c1)c4ccc(OC)c(Br)c4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 P05 compound treatment 140420.0 -250000.0 -1.25 153170.0 -182000.0 -0.86 -1.4882 -0.9832 3011477 CMLD3_000258 COc1cccc(c1)[C@@H]2Oc3ccc(Br)cc3C(=O)[C@H]2O 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 P06 compound treatment 153640.0 -237000.0 -1.18 162250.0 -173000.0 -0.81 -1.4113 -0.9834 3556277 CMLD3_000259 COC(=O)[C@H](COC(C)(C)C)NC(=O)O[C@H]1[C@@H](Oc2ccc(OC)cc2C1=O)c3cccc(OC)c3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 P07 compound treatment 155680.0 -235000.0 -1.17 164480.0 -171000.0 -0.8 -1.3967 -0.9831 3556279 CMLD3_000260 COc1ccc2O[C@H]([C@H](OC(=O)NCCc3ccc(OC)c(OC)c3)C(=O)c2c1)c4ccc(OC)c(Br)c4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 P08 compound treatment 268720.0 -122000.0 -0.61 223840.0 -111000.0 -0.52 -0.8 -0.9973 3556280 CMLD3_000261 COc1ccc2C(=O)[C@@H](OC(=O)NS(=O)(=O)c3ccc(C)cc3)[C@@H](Oc2c1)c4cccc(c4)C(F)(F)F 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 P09 mock treatment 221650.0 -169000.0 -0.84 169200.0 -166000.0 -0.78 -1.148 -0.9993 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 P10 compound treatment 160420.0 -230000.0 -1.15 202130.0 -133000.0 -0.63 -1.2547 -0.9594 3556282 CMLD3_000262 COc1ccc2C(=O)[C@H](OC(=O)NS(=O)(=O)c3ccc(C)cc3)[C@H](Oc2c1)c4ccc5OCOc5c4 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 P11 mock treatment 179060.0 -211000.0 -1.05 227900.0 -107000.0 -0.51 -1.1032 -0.9432 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 P12 mock treatment 194440.0 -196000.0 -0.98 272130.0 -63200.0 -0.3 -0.9017 -0.8822 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 P13 compound treatment 121000.0 -269000.0 -1.34 169340.0 -166000.0 -0.78 -1.503 -0.9665 3556284 CMLD3_000263 CCOC(=O)OC[C@H]1O[C@@H](C=C[C@@H]1OC(=O)OCC)c2ccccc2 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 P14 compound treatment 13560.0 -377000.0 -1.88 12930.0 -322000.0 -1.52 -2.4026 -0.9943 3556286 CMLD3_000264 CCOC(=O)OC[C@H]1O[C@@H](C=C[C@@H]1OC(=O)OCC)C#Cc2ccc(F)cc2F 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 P15 compound treatment 246080.0 -144000.0 -0.72 153700.0 -182000.0 -0.85 -1.1132 -0.9964 3556288 CMLD3_000265 Cc1cc(C)cc(/C=C/[C@@H]2OC[C@@H](O)[C@H]2Oc3ccc(cc3)C4CCCC4)c1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 P16 compound treatment 156520.0 -234000.0 -1.17 210440.0 -125000.0 -0.59 -1.2408 -0.9495 3556289 CMLD3_000266 Cc1cc(F)ccc1O[C@H]2C=C[C@H](O[C@@H]2CO)c3ccc4OCOc4c3 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 P17 compound treatment 477690.0 87400.0 0.44 221810.0 -114000.0 -0.53 -0.0687 -0.0997 3556073 CMLD3_000267 Clc1cc2nc3-c4ccccc4OC(CC=C)(c5ccccc5)c3nc2cc1Cl 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 P18 compound treatment 466160.0 75900.0 0.38 258630.0 -76700.0 -0.36 0.013 0.0248 3556291 CMLD3_000268 COc1ccc(cc1)C(=O)Oc2cc(OC)cc(OC)c2C(=O)C 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 P19 compound treatment 263000.0 -127000.0 -0.64 216370.0 -119000.0 -0.56 -0.8451 -0.998 3556292 CMLD3_000269 CC(=C)C(O)/C=C/c1ccc(Br)cc1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 P20 mock treatment 317620.0 -72600.0 -0.36 333170.0 -2150.0 -0.01 -0.2637 -0.7266 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 P21 compound treatment 301540.0 -88700.0 -0.44 232550.0 -103000.0 -0.48 -0.6551 -0.9991 3556294 CMLD3_000270 COC(=O)N[C@@H](/C=C/c1ccco1)[C@@]2(CCCC2=O)C(=O)OC 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 P22 compound treatment 108750.0 -282000.0 -1.41 104760.0 -231000.0 -1.08 -1.761 -0.9918 3556296 CMLD3_000271 CC1(C)O[C@H]([C@@H](O1)C(O)(c2cc(F)c(F)c(F)c2)c3cc(F)c(F)c(F)c3)C(O)(c4cc(F)c(F)c(F)c4)c5cc(F)c(F)c(F)c5 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 P23 compound treatment 344480.0 -45800.0 -0.23 237410.0 -97900.0 -0.46 -0.4873 -0.9478 3556298 CMLD3_000272 COC(=O)N[C@H](C(C(=O)C)C(=O)OCC=C)c1ccco1 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.2284 P24 mock treatment 366800.0 -23500.0 -0.12 291530.0 -43800.0 -0.21 -0.2285 -0.9642 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base A01 mock treatment 550740.0 -54400.0 -0.27 550660.0 -26600.0 -0.13 -1.6526 -0.7686 472160.0 -91098.1842105259 -1.06445064414472 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base A02 mock treatment 585830.0 -19300.0 -0.1 603570.0 26300.0 0.12 -0.2431 -0.4078 514290.0 -48968.1842105259 -0.572176225873323 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base A03 mock treatment 410080.0 -195000.0 -0.97 619960.0 42700.0 0.2 -0.4869 -0.4808 562400.0 -858.184210525942 -0.0100275844530347 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base A04 mock treatment 608320.0 3220.0 0.02 588610.0 11300.0 0.05 -0.403 -0.6423 520600.0 -42658.1842105259 -0.498446067333268 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base A05 mock treatment 604120.0 -982.0 0.0 608080.0 30800.0 0.14 -0.6246 -0.6235 511850.0 -51408.1842105259 -0.600686778462504 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base A06 mock treatment 201550.0 -404000.0 -2.02 557120.0 -20200.0 -0.09 -1.7885 -0.7802 520400.0 -42858.1842105259 -0.500782997873365 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base A07 mock treatment 630130.0 25000.0 0.13 542670.0 -34600.0 -0.16 -0.0409 -0.1742 554720.0 -8538.18421052594 -0.0997657171927523 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base A08 mock treatment 545080.0 -60000.0 -0.3 208510.0 -369000.0 -1.73 -1.7487 -0.8564 502450.0 -60808.1842105259 -0.710522513847054 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base A09 mock treatment 582270.0 -22800.0 -0.11 562310.0 -15000.0 -0.07 -2.158 -0.5385 220660.0 -342598.184210526 -4.00314079831646 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base A10 mock treatment 628200.0 23100.0 0.12 303200.0 -274000.0 -1.29 -0.6616 -0.5011 542430.0 -20828.1842105259 -0.243370098881701 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base A11 mock treatment 503640.0 -101000.0 -0.51 628480.0 51200.0 0.24 -0.7148 -0.7046 525160.0 -38098.1842105259 -0.445164051019061 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base A12 mock treatment 603110.0 -1990.0 -0.01 493990.0 -83300.0 -0.39 -1.1564 -0.7799 453160.0 -110098.184210526 -1.28645904545391 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base A13 mock treatment 433760.0 -171000.0 -0.86 527880.0 -49400.0 -0.23 -1.2758 -0.9173 517450.0 -45808.1842105259 -0.535252723339793 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base A14 mock treatment 558320.0 -46800.0 -0.23 554300.0 -23000.0 -0.11 -0.3702 -0.9681 544870.0 -18388.1842105259 -0.21485954629252 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base A15 mock treatment 578850.0 -26300.0 -0.13 342080.0 -235000.0 -1.11 -1.2718 -0.7773 461150.0 -102108.184210526 -1.19309867037705 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base A16 mock treatment 209760.0 -395000.0 -1.97 375910.0 -201000.0 -0.95 -2.8113 -0.8964 519070.0 -44188.1842105259 -0.516323585965009 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base A17 mock treatment 332020.0 -273000.0 -1.36 610260.0 33000.0 0.16 -1.0959 -0.7115 517080.0 -46178.1842105259 -0.539576044838972 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base A18 mock treatment 620830.0 15700.0 0.08 616370.0 39100.0 0.18 -0.137 -0.2855 527280.0 -35978.1842105259 -0.420392587294035 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base A19 mock treatment 370900.0 -234000.0 -1.17 488100.0 -89200.0 -0.42 -1.6735 -0.8994 451060.0 -112198.184210526 -1.31099681612493 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base A20 mock treatment 567890.0 -37200.0 -0.19 574660.0 -2620.0 -0.01 -0.5159 -0.5947 490750.0 -72508.1842105259 -0.847232950442718 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base A21 mock treatment 236520.0 -369000.0 -1.84 433370.0 -144000.0 -0.68 -2.6034 -0.8796 517140.0 -46118.1842105259 -0.538874965676943 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base A22 mock treatment 520870.0 -84200.0 -0.42 537460.0 -39800.0 -0.19 -0.7166 -0.7632 493230.0 -70028.1842105259 -0.818255011745517 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base A23 mock treatment 488660.0 -116000.0 -0.58 564200.0 -13100.0 -0.06 -0.8334 -0.8277 542720.0 -20538.1842105259 -0.239981549598561 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base A24 mock treatment 402340.0 -203000.0 -1.01 446930.0 -130000.0 -0.61 -1.5968 -0.9741 510560.0 -52698.1842105259 -0.615759980446128 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base B01 mock treatment 629760.0 24700.0 0.12 626330.0 49100.0 0.23 0.2265 0.7275 558200.0 -5058.18421052594 -0.0591031257950678 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base B02 mock treatment 649920.0 44800.0 0.22 644030.0 66800.0 0.31 0.2381 0.612 558930.0 -4328.18421052594 -0.0505733293237144 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base B03 mock treatment 665530.0 60400.0 0.3 649800.0 72500.0 0.34 0.1215 0.2264 544830.0 -18428.1842105259 -0.21532693240054 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base B04 mock treatment 669070.0 64000.0 0.32 557310.0 -20000.0 -0.09 -0.0084 -0.0185 536970.0 -26288.1842105259 -0.307168302626344 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base B05 mock treatment 675570.0 70500.0 0.35 545040.0 -32200.0 -0.15 -0.0981 -0.205 542620.0 -20638.1842105259 -0.241150014868609 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base B06 mock treatment 649920.0 44800.0 0.22 658940.0 81700.0 0.38 0.2053 0.3932 540550.0 -22708.1842105259 -0.265337245958611 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base B07 mock treatment 614250.0 9150.0 0.05 660930.0 83700.0 0.39 0.339 0.7616 566660.0 3401.81578947406 0.0397490360510274 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base B08 mock treatment 650650.0 45500.0 0.23 667470.0 90200.0 0.42 0.45 0.845 582680.0 19421.8157894741 0.226937172312782 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base B09 mock treatment 630180.0 25100.0 0.13 629810.0 52500.0 0.25 0.7774 0.8343 632250.0 68991.8157894741 0.806145406675777 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base B10 mock treatment 531430.0 -73700.0 -0.37 663270.0 86000.0 0.4 -0.032 -0.0421 527280.0 -35978.1842105259 -0.420392587294035 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base B11 mock treatment 627170.0 22100.0 0.11 643280.0 66000.0 0.31 0.2793 0.7667 576490.0 13231.8157894741 0.154609172096786 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base B12 mock treatment 598420.0 -6680.0 -0.03 633470.0 56200.0 0.26 0.1132 0.3571 573460.0 10201.8157894741 0.119204674414319 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base B13 mock treatment 548480.0 -56600.0 -0.28 606930.0 29700.0 0.14 -0.1926 -0.3121 522510.0 -40748.1842105259 -0.476128380675344 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base B14 mock treatment 598200.0 -6900.0 -0.03 579630.0 2350.0 0.01 0.0431 0.1556 583870.0 20611.8157894741 0.240841909026358 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base B15 mock treatment 611430.0 6330.0 0.03 634250.0 57000.0 0.27 0.0881 0.2869 565120.0 1861.81578947406 0.0217546708922819 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base B16 mock treatment 583150.0 -22000.0 -0.11 575000.0 -2280.0 -0.01 0.0527 0.0745 531720.0 -31538.1842105259 -0.368512729303886 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base B17 mock treatment 636070.0 31000.0 0.15 617210.0 39900.0 0.19 0.0628 0.1338 531520.0 -31738.1842105259 -0.370849659843983 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base B18 mock treatment 655480.0 50400.0 0.25 528530.0 -48700.0 -0.23 0.1551 0.3906 576680.0 13421.8157894741 0.156829256109878 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base B19 mock treatment 618720.0 13600.0 0.07 589330.0 12100.0 0.06 -0.1426 -0.3349 527630.0 -35628.1842105259 -0.416302958848866 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base B20 mock treatment 628160.0 23100.0 0.12 513440.0 -63800.0 -0.3 -0.4197 -0.6306 556700.0 -6558.18421052594 -0.0766301048457939 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base B21 mock treatment 575110.0 -30000.0 -0.15 603450.0 26200.0 0.12 -0.6666 -0.7055 509810.0 -53448.1842105259 -0.624523469971491 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base B22 mock treatment 595150.0 -9950.0 -0.05 563600.0 -13700.0 -0.06 -0.3759 -0.602 561640.0 -1618.18421052594 -0.0189079205054026 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base B23 mock treatment 569440.0 -35700.0 -0.18 504690.0 -72600.0 -0.34 -0.4299 -0.8692 560560.0 -2698.18421052594 -0.0315273454219254 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base B24 mock treatment 411600.0 -194000.0 -0.97 573600.0 -3680.0 -0.02 -1.0104 -0.8209 506350.0 -56908.1842105259 -0.664952368315166 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base C01 mock treatment 562260.0 -42800.0 -0.21 541810.0 -35500.0 -0.17 -1.1733 -0.8139 462880.0 -100378.184210526 -1.17288422120521 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base C02 mock treatment 377970.0 -227000.0 -1.13 608970.0 31700.0 0.15 -1.1793 -0.7854 507520.0 -55738.1842105259 -0.6512813246556 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base C03 mock treatment 589850.0 -15300.0 -0.08 526120.0 -51200.0 -0.24 -0.8147 -0.8441 502290.0 -60968.1842105259 -0.712392058279132 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base C04 mock treatment 270310.0 -335000.0 -1.67 292000.0 -285000.0 -1.34 -2.2821 -0.9473 501440.0 -61818.1842105259 -0.722324013074543 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base C05 mock treatment 560650.0 -44500.0 -0.22 566400.0 -10900.0 -0.05 -0.9899 -0.8005 499040.0 -64218.1842105259 -0.750367179555705 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base C06 mock treatment 635060.0 30000.0 0.15 333380.0 -244000.0 -1.15 -1.5126 -0.8179 466720.0 -96538.1842105259 -1.12801515483535 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base C07 mock treatment 444920.0 -160000.0 -0.8 588390.0 11100.0 0.05 -1.1677 -0.8462 497450.0 -65808.1842105259 -0.768945777349474 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base C08 mock treatment 550960.0 -54100.0 -0.27 537380.0 -39900.0 -0.19 -0.6804 -0.8572 545080.0 -18178.1842105259 -0.212405769225419 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base C09 mock treatment 580590.0 -24500.0 -0.12 596990.0 19700.0 0.09 -0.345 -0.5654 556890.0 -6368.18421052594 -0.0744100208327019 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base C10 mock treatment 554740.0 -50400.0 -0.25 649720.0 72400.0 0.34 -0.4051 -0.53 523780.0 -39478.1842105259 -0.461288871745729 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base C11 mock treatment 565380.0 -39700.0 -0.2 544590.0 -32700.0 -0.15 -0.9197 -0.7631 467400.0 -95858.1842105259 -1.12006959099902 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base C12 mock treatment 523890.0 -81200.0 -0.41 512860.0 -64400.0 -0.3 -1.9159 -0.712 341780.0 -221478.184210526 -2.58789566323383 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base C13 mock treatment 542090.0 -63000.0 -0.31 577530.0 252.0 0.0 -0.8137 -0.8295 506570.0 -56688.1842105259 -0.66238174472106 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base C14 mock treatment 555920.0 -49200.0 -0.25 536660.0 -40600.0 -0.19 -1.9266 -0.646 521190.0 -42068.1842105259 -0.491552122239983 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base C15 mock treatment 560020.0 -45100.0 -0.23 560410.0 -16900.0 -0.08 -0.8251 -0.7766 481000.0 -82258.1842105259 -0.961158314272437 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base C16 mock treatment 552190.0 -52900.0 -0.26 551490.0 -25800.0 -0.12 -0.83 -0.8446 492810.0 -70448.1842105259 -0.82316256587972 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base C17 mock treatment 496430.0 -109000.0 -0.54 523360.0 -53900.0 -0.25 -0.8768 -0.9358 507370.0 -55888.1842105259 -0.653034022560673 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base C18 mock treatment 414080.0 -191000.0 -0.95 392000.0 -185000.0 -0.87 -1.633 -0.9824 487310.0 -75948.1842105259 -0.887428155732383 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base C19 mock treatment 481620.0 -123000.0 -0.62 448700.0 -129000.0 -0.6 -1.3831 -0.9799 483220.0 -80038.1842105259 -0.935218385277363 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base C20 mock treatment 404020.0 -201000.0 -1.0 530250.0 -47000.0 -0.22 -1.2958 -0.9138 513360.0 -49898.1842105259 -0.583042952884773 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base C21 mock treatment 546730.0 -58400.0 -0.29 282770.0 -295000.0 -1.39 -1.727 -0.912 490460.0 -72798.1842105259 -0.850621499725858 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base C22 mock treatment 523130.0 -82000.0 -0.41 533920.0 -43400.0 -0.2 -1.6708 -0.7895 491280.0 -71978.1842105259 -0.841040084511461 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base C23 mock treatment 470910.0 -134000.0 -0.67 413920.0 -163000.0 -0.77 -1.6072 -0.9795 470560.0 -92698.1842105259 -1.08314608846549 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base C24 mock treatment 424510.0 -181000.0 -0.9 348750.0 -229000.0 -1.07 -2.0151 -0.9961 482830.0 -80428.1842105259 -0.939775399830551 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base D01 mock treatment 667710.0 62600.0 0.31 610150.0 32900.0 0.15 0.1513 0.4083 558920.0 -4338.18421052594 -0.0506901758507193 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base D02 mock treatment 617950.0 12800.0 0.06 670940.0 93700.0 0.44 0.2505 0.4337 585370.0 22111.8157894741 0.258368888077084 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base D03 mock treatment 546240.0 -58900.0 -0.29 633930.0 56700.0 0.27 -0.1464 -0.3123 541940.0 -21318.1842105259 -0.249095578704939 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base D04 mock treatment 447560.0 -158000.0 -0.79 658290.0 81000.0 0.38 -0.6571 -0.5915 509920.0 -53338.1842105259 -0.623238158174438 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base D05 mock treatment 628430.0 23300.0 0.12 656800.0 79500.0 0.37 -0.1094 -0.1654 522030.0 -41228.1842105259 -0.481737013971576 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base D06 mock treatment 670080.0 65000.0 0.32 646920.0 69600.0 0.33 0.1145 0.1886 529550.0 -33708.1842105259 -0.393868425663936 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base D07 mock treatment 673560.0 68500.0 0.34 615210.0 37900.0 0.18 0.1946 0.4903 558620.0 -4638.18421052594 -0.0541955716608645 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base D08 mock treatment 683770.0 78700.0 0.39 577760.0 482.0 0.0 0.252 0.5361 582820.0 19561.8157894741 0.22857302369085 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base D09 mock treatment 702970.0 97900.0 0.49 599300.0 22000.0 0.1 0.1903 0.3536 562240.0 -1018.18421052594 -0.0118971288851122 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base D10 mock treatment 621130.0 16000.0 0.08 594210.0 16900.0 0.08 0.0428 0.1509 544650.0 -18608.1842105259 -0.217430169886627 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base D11 mock treatment 675040.0 69900.0 0.35 632290.0 55000.0 0.26 0.0881 0.1643 549120.0 -14138.1842105259 -0.165199772315463 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base D12 mock treatment 584960.0 -20100.0 -0.1 636900.0 59600.0 0.28 0.1084 0.3061 553360.0 -9898.18421052594 -0.115656844865411 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base D13 mock treatment 628090.0 23000.0 0.11 619040.0 41800.0 0.2 -0.4012 -0.3606 470080.0 -93178.1842105259 -1.08875472176172 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base D14 mock treatment 560420.0 -44700.0 -0.22 602080.0 24800.0 0.12 -0.5732 -0.6426 492260.0 -70998.1842105259 -0.829589124864987 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base D15 mock treatment 639360.0 34300.0 0.17 644480.0 67200.0 0.32 0.0481 0.0941 560800.0 -2458.18421052594 -0.0287230287738092 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base D16 mock treatment 623170.0 18100.0 0.09 569860.0 -7420.0 -0.03 -0.0611 -0.342 550690.0 -12568.1842105259 -0.146854867575703 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base D17 mock treatment 648290.0 43200.0 0.22 393210.0 -184000.0 -0.87 -0.418 -0.4446 539250.0 -24008.1842105259 -0.280527294469241 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base D18 mock treatment 608060.0 2960.0 0.01 444190.0 -133000.0 -0.63 -0.5957 -0.7944 535810.0 -27448.1842105259 -0.320722499758906 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base D19 mock treatment 607780.0 2680.0 0.01 620130.0 42900.0 0.2 -0.3417 -0.5021 533120.0 -30138.1842105259 -0.352154215523208 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base D20 mock treatment 565140.0 -40000.0 -0.2 568070.0 -9210.0 -0.04 -0.487 -0.7798 549200.0 -14058.1842105259 -0.164265000099424 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base D21 mock treatment 569010.0 -36100.0 -0.18 577540.0 262.0 0.0 -0.2181 -0.8177 547730.0 -15528.1842105259 -0.181441439569136 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base D22 mock treatment 559710.0 -45400.0 -0.23 562980.0 -14300.0 -0.07 -1.2202 -0.7131 425780.0 -137478.184210526 -1.60638483639317 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base D23 mock treatment 566290.0 -38800.0 -0.19 400590.0 -177000.0 -0.83 -1.4097 -0.8874 512500.0 -50758.1842105259 -0.593091754207189 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base D24 mock treatment 543680.0 -61400.0 -0.31 516110.0 -61200.0 -0.29 -0.6237 -0.9493 522980.0 -40278.1842105259 -0.470636593906116 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base E01 mock treatment 586240.0 -18900.0 -0.09 649440.0 72200.0 0.34 0.0578 0.1584 556000.0 -7258.18421052594 -0.0848093617361327 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base E02 mock treatment 640600.0 35500.0 0.18 633220.0 55900.0 0.26 0.0254 0.0526 532180.0 -31078.1842105259 -0.363137789061663 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base E03 mock treatment 683290.0 78200.0 0.39 674030.0 96800.0 0.46 0.3386 0.4989 538210.0 -25048.1842105259 -0.292679333277744 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base E04 mock treatment 661440.0 56300.0 0.28 615530.0 38300.0 0.18 0.4086 0.9325 570570.0 7311.81578947406 0.08543602810992 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base E05 mock treatment 590180.0 -14900.0 -0.07 636600.0 59300.0 0.28 0.0946 0.2118 542000.0 -21258.1842105259 -0.24839449954291 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base E06 mock treatment 612760.0 7660.0 0.04 263040.0 -314000.0 -1.48 -0.5503 -0.3634 591210.0 27951.8157894741 0.326607259847911 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base E07 mock treatment 710730.0 106000.0 0.53 667210.0 89900.0 0.42 1.0159 0.9915 604080.0 40821.8157894741 0.476988740103141 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base E08 mock treatment 684760.0 79700.0 0.4 663900.0 86600.0 0.41 0.4102 0.6055 586090.0 22831.8157894741 0.266781838021433 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base E09 mock treatment 660660.0 55600.0 0.28 633690.0 56400.0 0.27 0.5425 0.9964 589190.0 25931.8157894741 0.303004261392933 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base E10 mock treatment 643690.0 38600.0 0.19 679470.0 102000.0 0.48 0.3502 0.5887 582080.0 18821.8157894741 0.219926380692492 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base E11 mock treatment 606970.0 1870.0 0.01 688540.0 111000.0 0.52 0.0274 0.042 530720.0 -32538.1842105259 -0.38019738200437 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base E12 mock treatment 564000.0 -41100.0 -0.21 641830.0 64600.0 0.3 -0.0806 -0.1952 555110.0 -8148.18421052594 -0.0952087026395635 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base E13 mock treatment 606270.0 1170.0 0.01 675370.0 98100.0 0.46 0.0791 0.1008 586080.0 22821.8157894741 0.266664991494428 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base E14 mock treatment 612850.0 7750.0 0.04 617870.0 40600.0 0.19 0.2847 0.9188 578910.0 15651.8157894741 0.182886031631957 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base E15 mock treatment 672410.0 67300.0 0.34 557970.0 -19300.0 -0.09 0.5278 0.7783 604110.0 40851.8157894741 0.477339279684155 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base E16 mock treatment 646510.0 41400.0 0.21 482800.0 -94500.0 -0.44 -0.1496 -0.2567 579520.0 16261.8157894741 0.190013669779252 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base E17 mock treatment 654810.0 49700.0 0.25 650640.0 73400.0 0.35 0.3915 0.8773 572670.0 9411.81578947406 0.109973798780937 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base E18 mock treatment 642160.0 37100.0 0.19 632590.0 55300.0 0.26 0.2337 0.5851 578690.0 15431.8157894741 0.180315408037851 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base E19 mock treatment 587540.0 -17600.0 -0.09 615380.0 38100.0 0.18 0.0995 0.2685 549530.0 -13728.1842105259 -0.160409064708265 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base E20 mock treatment 496070.0 -109000.0 -0.54 558240.0 -19000.0 -0.09 -0.4744 -0.7294 565680.0 2421.81578947406 0.028298076404553 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base E21 mock treatment 277940.0 -327000.0 -1.63 577850.0 572.0 0.0 -1.2164 -0.6833 503450.0 -59808.1842105259 -0.69883786114657 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base E22 mock treatment 581020.0 -24100.0 -0.12 579710.0 2430.0 0.01 -0.0991 -0.7227 558530.0 -4728.18421052594 -0.055247190403908 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base E23 mock treatment 559770.0 -45300.0 -0.23 508040.0 -69200.0 -0.33 -0.3988 -0.871 561760.0 -1498.18421052594 -0.0175057621813445 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base E24 mock treatment 494080.0 -111000.0 -0.55 309380.0 -268000.0 -1.26 -0.8883 -0.6365 551170.0 -12088.1842105259 -0.141246234279471 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base F01 mock treatment 665250.0 60100.0 0.3 630460.0 53200.0 0.25 0.0831 0.1729 542890.0 -20368.1842105259 -0.237995158639479 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base F02 mock treatment 524590.0 -80500.0 -0.4 629620.0 52300.0 0.25 0.0679 0.1319 575110.0 11851.8157894741 0.138484351370118 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base F03 mock treatment 549180.0 -55900.0 -0.28 665550.0 88300.0 0.42 -0.4218 -0.4781 508040.0 -55218.1842105259 -0.645205305251348 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base F04 mock treatment 728000.0 123000.0 0.61 626240.0 49000.0 0.23 0.529 0.7862 572710.0 9451.81578947406 0.110441184888956 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base F05 mock treatment 346460.0 -259000.0 -1.29 605530.0 28300.0 0.13 -0.4416 -0.3346 582940.0 19681.8157894741 0.229975182014908 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base F06 mock treatment 624640.0 19500.0 0.1 624980.0 47700.0 0.22 -0.3048 -0.2653 578400.0 15141.8157894741 0.17692685875471 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base F07 mock treatment 730610.0 126000.0 0.63 540640.0 -36600.0 -0.17 -0.1808 -0.1361 467520.0 -95738.1842105259 -1.11866743267496 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base F08 mock treatment 726660.0 122000.0 0.61 617600.0 40300.0 0.19 0.4437 0.6452 582490.0 19231.8157894741 0.22471708829969 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base F09 mock treatment 592600.0 -12500.0 -0.06 673160.0 95900.0 0.45 0.3304 0.6345 565010.0 1751.81578947406 0.0204693590952287 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base F10 mock treatment 608900.0 3800.0 0.02 300320.0 -277000.0 -1.3 -0.7534 -0.5713 545820.0 -17438.1842105259 -0.20375912622706 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base F11 mock treatment 613380.0 8280.0 0.04 417600.0 -160000.0 -0.75 -0.1189 -0.1179 548160.0 -15098.1842105259 -0.176417038907928 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base F12 mock treatment 651000.0 45900.0 0.23 398240.0 -179000.0 -0.84 0.0443 0.0384 627680.0 64421.8157894741 0.752746543834565 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base F13 mock treatment 605020.0 -81.5 0.0 637700.0 60400.0 0.28 -0.2543 -0.3982 522420.0 -40838.1842105259 -0.477179999418387 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base F14 mock treatment 652380.0 47300.0 0.24 576000.0 -1280.0 -0.01 -0.1028 -0.132 585460.0 22201.8157894741 0.259420506820128 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base F15 mock treatment 604490.0 -612.0 0.0 664010.0 86700.0 0.41 0.4564 0.8323 589400.0 26141.8157894741 0.305458038460035 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base F16 mock treatment 696030.0 90900.0 0.45 661770.0 84500.0 0.4 0.4461 0.7377 566500.0 3241.81578947406 0.0378794916189499 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base F17 mock treatment 668520.0 63400.0 0.32 631460.0 54200.0 0.25 -0.1451 -0.1427 569030.0 5771.81578947406 0.0674416629511746 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base F18 mock treatment 502250.0 -103000.0 -0.51 549960.0 -27300.0 -0.13 -0.5275 -0.7577 524700.0 -38558.1842105259 -0.450538991261284 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base F19 mock treatment 583550.0 -21600.0 -0.11 637310.0 60000.0 0.28 -0.0243 -0.0508 533360.0 -29898.1842105259 -0.349349898875092 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base F20 mock treatment 673570.0 68500.0 0.34 693020.0 116000.0 0.54 0.6827 0.9364 580200.0 16941.8157894741 0.197959233615582 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base F21 mock treatment 561630.0 -43500.0 -0.22 657350.0 80100.0 0.38 -0.2193 -0.3315 553640.0 -9618.18421052594 -0.112385142109275 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base F22 mock treatment 430840.0 -174000.0 -0.87 525950.0 -51300.0 -0.24 -1.118 -0.7612 464190.0 -99068.1842105259 -1.15757732616757 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base F23 mock treatment 586580.0 -18500.0 -0.09 495060.0 -82200.0 -0.39 -0.2493 -0.6254 563890.0 631.815789474058 0.00738254807068652 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base F24 mock treatment 558720.0 -46400.0 -0.23 343850.0 -233000.0 -1.1 -0.921 -0.7271 569320.0 6061.81578947406 0.070830212234315 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base G01 mock treatment 651360.0 46300.0 0.23 623460.0 46200.0 0.22 0.064 0.1639 547810.0 -15448.1842105259 -0.180506667353097 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base G02 mock treatment 622080.0 17000.0 0.08 507370.0 -69900.0 -0.33 0.1001 0.1893 597760.0 34501.8157894741 0.403141735036082 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base G03 mock treatment 628320.0 23200.0 0.12 660350.0 83100.0 0.39 0.2809 0.686 565820.0 2561.81578947406 0.0299339277826208 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base G04 mock treatment 710140.0 105000.0 0.52 524290.0 -53000.0 -0.25 0.3558 0.519 570210.0 6951.81578947406 0.0812295531377458 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base G05 mock treatment 284640.0 -320000.0 -1.6 644760.0 67500.0 0.32 -0.4934 -0.2978 587840.0 24581.8157894741 0.28722998024728 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base G06 mock treatment 700170.0 95100.0 0.47 321560.0 -256000.0 -1.2 -0.0305 -0.0219 604160.0 40901.8157894741 0.47792351231918 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base G07 mock treatment 685540.0 80400.0 0.4 578640.0 1360.0 0.01 0.8906 0.842 629370.0 66111.8157894741 0.772493606898383 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base G08 mock treatment 678240.0 73100.0 0.37 659040.0 81800.0 0.38 1.313 0.9135 653040.0 89781.8157894741 1.04906933631884 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base G09 mock treatment 692240.0 87100.0 0.44 524000.0 -53300.0 -0.25 0.5849 0.6728 613610.0 50351.8157894741 0.588343480338754 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base G10 mock treatment 628840.0 23700.0 0.12 647900.0 70600.0 0.33 0.6484 0.899 587680.0 24421.8157894741 0.285360435815202 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base G11 mock treatment 402560.0 -203000.0 -1.01 699560.0 122000.0 0.58 -0.1989 -0.1493 604160.0 40901.8157894741 0.47792351231918 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base G12 mock treatment 626640.0 21500.0 0.11 668530.0 91300.0 0.43 -0.4133 -0.3841 494020.0 -69238.1842105259 -0.809024136112135 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base G13 mock treatment 704760.0 99700.0 0.5 675600.0 98300.0 0.46 0.1107 0.1191 509860.0 -53398.1842105259 -0.623939237336467 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base G14 mock treatment 669560.0 64500.0 0.32 672130.0 94900.0 0.45 0.5497 0.9139 581360.0 18101.8157894741 0.211513430748143 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base G15 mock treatment 688480.0 83400.0 0.42 657630.0 80400.0 0.38 0.5534 0.9096 572320.0 9061.81578947406 0.105884170335767 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base G16 mock treatment 676270.0 71200.0 0.36 568880.0 -8400.0 -0.04 0.1188 0.3283 560370.0 -2888.18421052594 -0.0337474294350174 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base G17 mock treatment 708450.0 103000.0 0.52 664030.0 86800.0 0.41 0.5727 0.8069 559690.0 -3568.18421052594 -0.0416929932713465 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base G18 mock treatment 665170.0 60100.0 0.3 646560.0 69300.0 0.33 0.2178 0.3098 587130.0 23871.8157894741 0.278933876829936 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base G19 mock treatment 595800.0 -9300.0 -0.05 568900.0 -8380.0 -0.04 0.0072 0.0582 572440.0 9181.81578947406 0.107286328659825 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base G20 mock treatment 540030.0 -65100.0 -0.33 538880.0 -38400.0 -0.18 -0.6395 -0.9649 527470.0 -35788.1842105259 -0.418172503280943 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base G21 mock treatment 554720.0 -50400.0 -0.25 537340.0 -39900.0 -0.19 -0.4813 -0.9262 552130.0 -11128.1842105259 -0.130028967687006 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base G22 mock treatment 541550.0 -63600.0 -0.32 530620.0 -46700.0 -0.22 -0.6658 -0.6361 577320.0 14061.8157894741 0.164307433838187 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base G23 mock treatment 542110.0 -63000.0 -0.31 447380.0 -130000.0 -0.61 -0.5543 -0.7552 568910.0 5651.81578947406 0.0660395046271165 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base G24 mock treatment 523070.0 -82000.0 -0.41 503610.0 -73700.0 -0.35 -0.4904 -0.7971 569120.0 5861.81578947406 0.0684932816942182 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base H01 mock treatment 537350.0 -67800.0 -0.34 618590.0 41300.0 0.19 -0.1596 -0.3898 556100.0 -7158.18421052594 -0.0836408964660843 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base H02 mock treatment 618630.0 13500.0 0.07 667720.0 90400.0 0.43 0.0549 0.1014 557990.0 -5268.18421052594 -0.0615569028621694 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base H03 mock treatment 662200.0 57100.0 0.29 503430.0 -73800.0 -0.35 0.1523 0.2935 578830.0 15571.8157894741 0.181951259415918 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base H04 mock treatment 595650.0 -9450.0 -0.05 659560.0 82300.0 0.39 0.3286 0.715 571160.0 7901.81578947406 0.0923299732032056 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base H05 mock treatment 654560.0 49500.0 0.25 576130.0 -1150.0 -0.01 0.2408 0.7416 581080.0 17821.8157894741 0.208241727992008 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base H06 mock treatment 717990.0 113000.0 0.56 457120.0 -120000.0 -0.57 0.1926 0.1963 549510.0 -13748.1842105259 -0.160642757762274 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base H07 mock treatment 709760.0 105000.0 0.52 312800.0 -264000.0 -1.24 -0.0094 -0.0065 601700.0 38441.8157894741 0.449179266675989 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base H08 mock treatment 695310.0 90200.0 0.45 372410.0 -205000.0 -0.96 0.1917 0.1537 610500.0 47241.8157894741 0.552004210440249 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base H09 mock treatment 746200.0 141000.0 0.7 680850.0 104000.0 0.49 0.7267 0.8269 578300.0 15041.8157894741 0.175758393484662 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base H10 mock treatment 647050.0 41900.0 0.21 655900.0 78600.0 0.37 0.8362 0.9396 617180.0 53921.8157894741 0.630057690479482 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base H11 mock treatment 345780.0 -259000.0 -1.3 579040.0 1760.0 0.01 -2.8085 -0.8109 319200.0 -244058.184210526 -2.85173512121076 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base H12 mock treatment 677230.0 72100.0 0.36 362310.0 -215000.0 -1.01 -0.3783 -0.2985 599250.0 35991.8157894741 0.420551867559803 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base H13 mock treatment 649520.0 44400.0 0.22 588570.0 11300.0 0.05 -0.8156 -0.4808 542480.0 -20778.1842105259 -0.242785866246677 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base H14 mock treatment 278930.0 -326000.0 -1.63 647740.0 70500.0 0.33 -1.0945 -0.5961 552830.0 -10428.1842105259 -0.121849710796667 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base H15 mock treatment 685530.0 80400.0 0.4 657770.0 80500.0 0.38 0.702 0.9849 595630.0 32371.8157894741 0.378253424784051 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base H16 mock treatment 641120.0 36000.0 0.18 603120.0 25800.0 0.12 -0.7058 -0.3264 597540.0 34281.8157894741 0.400571111441975 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base H17 mock treatment 706080.0 101000.0 0.5 612320.0 35000.0 0.16 0.5318 0.8827 583790.0 20531.8157894741 0.239907136810319 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base H18 mock treatment 646180.0 41100.0 0.21 639390.0 62100.0 0.29 0.3122 0.6346 588450.0 25191.8157894741 0.294357618394575 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base H19 mock treatment 686640.0 81500.0 0.41 623640.0 46400.0 0.22 -0.0518 -0.0616 560960.0 -2298.18421052594 -0.0268534843417318 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base H20 mock treatment 598360.0 -6740.0 -0.03 597410.0 20100.0 0.09 -0.2456 -0.3197 579200.0 15941.8157894741 0.186274580915097 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base H21 mock treatment 450080.0 -155000.0 -0.77 558770.0 -18500.0 -0.09 -0.2101 -0.2375 599050.0 35791.8157894741 0.418214937019706 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base H22 mock treatment 510050.0 -95100.0 -0.47 586990.0 9710.0 0.05 -1.6796 -0.5878 553390.0 -9868.18421052594 -0.115306305284396 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base H23 mock treatment 586940.0 -18200.0 -0.09 594690.0 17400.0 0.08 -0.2591 -0.5264 522560.0 -40698.1842105259 -0.47554414804032 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base H24 mock treatment 282740.0 -322000.0 -1.61 579320.0 2040.0 0.01 -1.1142 -0.6601 551110.0 -12148.1842105259 -0.1419473134415 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base I01 mock treatment 650020.0 44900.0 0.22 589220.0 11900.0 0.06 -0.0705 -0.1634 532530.0 -30728.1842105259 -0.359048160616494 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base I02 mock treatment 694030.0 88900.0 0.44 677780.0 101000.0 0.47 0.8335 0.9097 572930.0 9671.81578947406 0.113011808483062 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base I03 mock treatment 685010.0 79900.0 0.4 269960.0 -307000.0 -1.45 -0.2046 -0.1298 579240.0 15981.8157894741 0.186741967023117 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base I04 mock treatment 624690.0 19600.0 0.1 624410.0 47100.0 0.22 0.3466 0.8243 565950.0 2691.81578947406 0.0314529326336837 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base I05 mock treatment 723430.0 118000.0 0.59 621940.0 44700.0 0.21 0.6067 0.877 581650.0 18391.8157894741 0.214901980031283 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base I06 mock treatment 665830.0 60700.0 0.3 686620.0 109000.0 0.51 0.5169 0.6269 539370.0 -23888.1842105259 -0.279125136145183 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base I07 mock treatment 647490.0 42400.0 0.21 428390.0 -149000.0 -0.7 0.4616 0.3668 637490.0 74231.8157894741 0.867372986826313 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base I08 mock treatment 728590.0 123000.0 0.62 660210.0 82900.0 0.39 -0.1391 -0.0673 611530.0 48271.8157894741 0.564039402721747 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base I09 mock treatment 709280.0 104000.0 0.52 698640.0 121000.0 0.57 0.84 0.9565 586250.0 22991.8157894741 0.26865138245351 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base I10 mock treatment 295460.0 -310000.0 -1.55 654800.0 77500.0 0.36 -1.6994 -0.6132 567780.0 4521.81578947406 0.0528358470755695 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base I11 mock treatment 596900.0 -8200.0 -0.04 232980.0 -344000.0 -1.62 -0.3832 -0.2203 601920.0 38661.8157894741 0.451749890270095 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base I12 mock treatment 363550.0 -242000.0 -1.21 661140.0 83900.0 0.39 -0.3751 -0.2633 604990.0 41731.8157894741 0.487621774060581 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base I13 mock treatment 423120.0 -182000.0 -0.91 664610.0 87300.0 0.41 0.0519 0.0473 599330.0 36071.8157894741 0.421486639775842 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base I14 mock treatment 690170.0 85100.0 0.42 660820.0 83500.0 0.39 0.8654 0.995 606480.0 43221.8157894741 0.505031906584303 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base I15 mock treatment 729760.0 125000.0 0.62 604400.0 27100.0 0.13 0.8756 0.8548 583110.0 19851.8157894741 0.23196157297399 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base I16 mock treatment 651610.0 46500.0 0.23 649690.0 72400.0 0.34 0.1856 0.4009 564000.0 741.815789474058 0.00866785986773977 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base I17 mock treatment 717020.0 112000.0 0.56 344860.0 -232000.0 -1.09 0.2861 0.1898 586890.0 23631.8157894741 0.27612956018182 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base I18 mock treatment 482960.0 -122000.0 -0.61 700160.0 123000.0 0.58 0.5905 0.4881 606260.0 43001.8157894741 0.502461282990196 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base I19 mock treatment 676100.0 71000.0 0.35 383260.0 -194000.0 -0.91 0.0449 0.0406 576360.0 13101.8157894741 0.153090167245723 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base I20 mock treatment 646080.0 41000.0 0.2 269570.0 -308000.0 -1.45 -0.6848 -0.4508 582240.0 18981.8157894741 0.221795925124569 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base I21 mock treatment 575940.0 -29200.0 -0.15 468390.0 -109000.0 -0.51 -0.8008 -0.8134 552540.0 -10718.1842105259 -0.125238260079808 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base I22 mock treatment 509000.0 -96100.0 -0.48 565810.0 -11500.0 -0.05 -0.4674 -0.7573 561800.0 -1458.18421052594 -0.0170383760733252 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base I23 mock treatment 458580.0 -147000.0 -0.73 442740.0 -135000.0 -0.63 -0.8732 -0.8634 554080.0 -9178.18421052594 -0.107243894921062 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base I24 mock treatment 555740.0 -49400.0 -0.25 249680.0 -328000.0 -1.54 -1.0865 -0.6859 546830.0 -16428.1842105259 -0.191957626999572 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base J01 mock treatment 622990.0 17900.0 0.09 233310.0 -344000.0 -1.62 -0.9421 -0.5586 524190.0 -39068.1842105259 -0.456498164138531 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base J02 mock treatment 594260.0 -10800.0 -0.05 423040.0 -154000.0 -0.73 -0.4097 -0.5261 544820.0 -18438.1842105259 -0.215443778927545 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base J03 mock treatment 650210.0 45100.0 0.23 267520.0 -310000.0 -1.46 -0.8164 -0.5134 577830.0 14571.8157894741 0.170266606715434 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base J04 mock treatment 609520.0 4420.0 0.02 644530.0 67300.0 0.32 0.1494 0.2802 587440.0 24181.8157894741 0.282556119167086 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base J05 mock treatment 685120.0 80000.0 0.4 260570.0 -317000.0 -1.49 -1.1756 -0.5537 439430.0 -123828.184210526 -1.44688932703156 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base J06 mock treatment 747970.0 143000.0 0.71 354450.0 -223000.0 -1.05 0.075 0.057 578350.0 15091.8157894741 0.176342626119686 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base J07 mock treatment 704500.0 99400.0 0.5 693690.0 116000.0 0.55 0.9532 0.9855 608130.0 44871.8157894741 0.524311583540101 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base J08 mock treatment 673630.0 68500.0 0.34 650590.0 73300.0 0.34 0.2261 0.4285 560580.0 -2678.18421052594 -0.0312936523679157 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base J09 mock treatment 602080.0 -3020.0 -0.02 695520.0 118000.0 0.56 0.0678 0.0747 585630.0 22371.8157894741 0.26140689777921 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base J10 mock treatment 629120.0 24000.0 0.12 691490.0 114000.0 0.54 0.2355 0.4159 556510.0 -6748.18421052594 -0.0788501888588859 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base J11 mock treatment 670990.0 65900.0 0.33 647520.0 70200.0 0.33 0.1184 0.1963 530720.0 -32538.1842105259 -0.38019738200437 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base J12 mock treatment 666520.0 61400.0 0.31 653390.0 76100.0 0.36 0.4472 0.492 619090.0 55831.8157894741 0.652375377137407 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base J13 mock treatment 659780.0 54700.0 0.27 645600.0 68300.0 0.32 0.1901 0.3747 568500.0 5241.81578947406 0.061248797019918 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base J14 mock treatment 650720.0 45600.0 0.23 574460.0 -2820.0 -0.01 -1.1377 -0.5224 533020.0 -30238.1842105259 -0.353322680793256 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base J15 mock treatment 525190.0 -79900.0 -0.4 502350.0 -74900.0 -0.35 -0.1925 -0.279 600350.0 37091.8157894741 0.433404985530335 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base J16 mock treatment 665150.0 60000.0 0.3 555210.0 -22100.0 -0.1 0.526 0.681 621660.0 58401.8157894741 0.682404934577651 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base J17 mock treatment 700990.0 95900.0 0.48 677830.0 101000.0 0.47 0.6837 0.901 569490.0 6231.81578947406 0.0728166031933973 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base J18 mock treatment 694290.0 89200.0 0.45 609250.0 32000.0 0.15 0.5966 0.6121 633730.0 70471.8157894741 0.823438692672493 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base J19 mock treatment 729720.0 125000.0 0.62 638240.0 61000.0 0.29 0.7652 0.8392 614720.0 51461.8157894741 0.601313444836291 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base J20 mock treatment 547600.0 -57500.0 -0.29 590310.0 13000.0 0.06 -0.0241 -0.0752 569770.0 6511.81578947406 0.0760883059495328 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base J21 mock treatment 617800.0 12700.0 0.06 451050.0 -126000.0 -0.59 -0.7245 -0.6593 563590.0 331.815789474058 0.0038771522605413 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base J22 mock treatment 610650.0 5550.0 0.03 375440.0 -202000.0 -0.95 -0.472 -0.4713 581520.0 18261.8157894741 0.213382975180221 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base J23 mock treatment 539060.0 -66000.0 -0.33 346410.0 -231000.0 -1.09 -0.7997 -0.7001 555310.0 -7948.18421052594 -0.0928717720994667 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base J24 mock treatment 506640.0 -98500.0 -0.49 624350.0 47100.0 0.22 -0.2008 -0.3645 553780.0 -9478.18421052594 -0.110749290731207 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base K01 mock treatment 704250.0 99100.0 0.5 223330.0 -354000.0 -1.66 -0.2091 -0.1135 613890.0 50631.8157894741 0.59161518309489 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base K02 mock treatment 714190.0 109000.0 0.54 698190.0 121000.0 0.57 1.2747 0.992 625450.0 62191.8157894741 0.726689768312485 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base K03 mock treatment 731800.0 127000.0 0.63 692200.0 115000.0 0.54 1.0341 0.9639 586990.0 23731.8157894741 0.277298025451868 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base K04 mock treatment 645040.0 39900.0 0.2 691590.0 114000.0 0.54 1.1058 0.9282 622760.0 59501.8157894741 0.695258052548183 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base K05 mock treatment 304240.0 -301000.0 -1.5 693800.0 117000.0 0.55 0.1793 0.0954 599360.0 36101.8157894741 0.421837179356856 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base K06 mock treatment 710260.0 105000.0 0.53 607540.0 30300.0 0.14 0.8754 0.9253 602910.0 39651.8157894741 0.463317696443575 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base K07 mock treatment 804520.0 199000.0 1.0 685630.0 108000.0 0.51 1.7227 0.9583 665230.0 101971.815789474 1.19150525273774 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base K08 mock treatment 750740.0 146000.0 0.73 718460.0 141000.0 0.66 1.2792 0.9679 594460.0 31201.8157894741 0.364582381124484 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base K09 mock treatment 612760.0 7660.0 0.04 710800.0 134000.0 0.63 0.7244 0.8101 615650.0 52391.8157894741 0.612180171847742 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base K10 mock treatment 682530.0 77400.0 0.39 759940.0 183000.0 0.86 0.7319 0.7537 561860.0 -1398.18421052594 -0.0163372969112961 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base K11 mock treatment 428120.0 -177000.0 -0.88 742940.0 166000.0 0.78 1.2075 0.5635 660700.0 97441.8157894741 1.13857377600455 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base K12 mock treatment 708540.0 103000.0 0.52 506800.0 -70500.0 -0.33 0.4643 0.3792 650720.0 87461.8157894741 1.02196094205372 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base K13 mock treatment 766810.0 162000.0 0.81 569810.0 -7470.0 -0.04 1.0135 0.8374 626430.0 63171.8157894741 0.73814072795896 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base K14 mock treatment 732610.0 128000.0 0.64 651360.0 74100.0 0.35 1.0517 0.9582 624980.0 61721.8157894741 0.721197981543258 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base K15 mock treatment 725940.0 121000.0 0.6 602670.0 25400.0 0.12 0.894 0.8533 632430.0 69171.8157894741 0.808248644161864 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base K16 mock treatment 735330.0 130000.0 0.65 691710.0 114000.0 0.54 1.105 0.8714 643960.0 80701.8157894741 0.942972689798445 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base K17 mock treatment 704360.0 99300.0 0.5 719040.0 142000.0 0.67 1.5634 0.9626 655550.0 92291.8157894741 1.07839781459706 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base K18 mock treatment 754880.0 150000.0 0.75 698930.0 122000.0 0.57 1.6716 0.9737 642630.0 79371.8157894741 0.927432101706801 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base K19 mock treatment 646790.0 41700.0 0.21 687870.0 111000.0 0.52 0.6957 0.6827 548640.0 -14618.1842105259 -0.170808405611695 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base K20 mock treatment 503930.0 -101000.0 -0.51 643450.0 66200.0 0.31 0.3854 0.4086 620760.0 57501.8157894741 0.671888747147215 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base K21 mock treatment 521850.0 -83300.0 -0.42 617370.0 40100.0 0.19 0.437 0.4724 622630.0 59371.8157894741 0.69373904769712 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base K22 mock treatment 682720.0 77600.0 0.39 628360.0 51100.0 0.24 0.3079 0.5073 538520.0 -24738.1842105259 -0.289057090940594 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base K23 mock treatment 628390.0 23300.0 0.12 561760.0 -15500.0 -0.07 0.7588 0.7175 633230.0 69971.8157894741 0.817596366322251 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base K24 mock treatment 529830.0 -75300.0 -0.38 388450.0 -189000.0 -0.89 -0.4413 -0.4236 562240.0 -1018.18421052594 -0.0118971288851122 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base L01 mock treatment 668890.0 63800.0 0.32 667290.0 90000.0 0.42 0.5727 0.9437 585280.0 22021.8157894741 0.257317269334041 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base L02 mock treatment 687730.0 82600.0 0.41 631410.0 54100.0 0.25 0.6157 0.9798 585840.0 22581.8157894741 0.263860674846312 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base L03 mock treatment 304320.0 -301000.0 -1.5 625290.0 48000.0 0.23 -0.3825 -0.2317 617560.0 54301.8157894741 0.634497858505666 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base L04 mock treatment 672490.0 67400.0 0.34 665680.0 88400.0 0.42 0.3554 0.6494 568210.0 4951.81578947406 0.0578602477367777 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base L05 mock treatment 647730.0 42600.0 0.21 498250.0 -79000.0 -0.37 0.2267 0.3718 587780.0 24521.8157894741 0.286528901085251 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base L06 mock treatment 714310.0 109000.0 0.55 598970.0 21700.0 0.1 0.8765 0.883 594980.0 31721.8157894741 0.370658400528736 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base L07 mock treatment 727420.0 122000.0 0.61 485830.0 -91400.0 -0.43 0.3025 0.3728 575270.0 12011.8157894741 0.140353895802195 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base L08 mock treatment 347590.0 -258000.0 -1.29 624690.0 47400.0 0.22 -1.6589 -0.5216 613400.0 50141.8157894741 0.585889703271652 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base L09 mock treatment 692410.0 87300.0 0.44 682240.0 105000.0 0.49 0.5693 0.6518 538650.0 -24608.1842105259 -0.287538086089531 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base L10 mock treatment 692000.0 86900.0 0.43 711220.0 134000.0 0.63 0.7283 0.8792 570720.0 7461.81578947406 0.0871887260149927 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base L11 mock treatment 513520.0 -91600.0 -0.46 560760.0 -16500.0 -0.08 0.207 0.2109 570840.0 7581.81578947406 0.0885908843390507 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base L12 mock treatment 698820.0 93700.0 0.47 690560.0 113000.0 0.53 -0.0749 -0.0489 579890.0 16631.8157894741 0.194336991278431 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base L13 mock treatment 654760.0 49700.0 0.25 668700.0 91400.0 0.43 0.9678 0.9473 621980.0 58721.8157894741 0.686144023441806 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base L14 mock treatment 728760.0 124000.0 0.62 672860.0 95600.0 0.45 0.8726 0.9664 594900.0 31641.8157894741 0.369723628312697 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base L15 mock treatment 526750.0 -78400.0 -0.39 568400.0 -8880.0 -0.04 -0.3192 -0.4664 587200.0 23941.8157894741 0.27975180251897 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base L16 mock treatment 710270.0 105000.0 0.53 674640.0 97400.0 0.46 0.2208 0.2035 584770.0 21511.8157894741 0.251358096456794 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base L17 mock treatment 699360.0 94300.0 0.47 671910.0 94600.0 0.45 0.8112 0.9815 586400.0 23141.8157894741 0.270404080358583 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base L18 mock treatment 458750.0 -146000.0 -0.73 637060.0 59800.0 0.28 -0.0159 -0.0191 581920.0 18661.8157894741 0.218056836260414 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base L19 mock treatment 651230.0 46100.0 0.23 633240.0 56000.0 0.26 0.5333 0.7441 558940.0 -4318.18421052594 -0.0504564827967096 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base L20 mock treatment 688340.0 83200.0 0.42 575040.0 -2240.0 -0.01 0.3359 0.661 561170.0 -2088.18421052594 -0.0243997072746301 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base L21 mock treatment 634930.0 29800.0 0.15 576280.0 -998.0 0.0 0.3526 0.7924 579040.0 15781.8157894741 0.18440503648302 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base L22 mock treatment 639220.0 34100.0 0.17 540180.0 -37100.0 -0.17 0.2004 0.5265 584120.0 20861.8157894741 0.243763072201479 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base L23 mock treatment 565820.0 -39300.0 -0.2 463560.0 -114000.0 -0.53 -0.7906 -0.8613 550830.0 -12428.1842105259 -0.145219016197635 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base L24 mock treatment 541210.0 -63900.0 -0.32 515040.0 -62200.0 -0.29 -0.1037 -0.1939 588450.0 25191.8157894741 0.294357618394575 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base M01 mock treatment 633410.0 28300.0 0.14 579170.0 1890.0 0.01 0.2899 0.8082 589380.0 26121.8157894741 0.305224345406025 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base M02 mock treatment 684410.0 79300.0 0.4 652160.0 74900.0 0.35 0.5672 0.9361 573250.0 9991.81578947406 0.116750897347217 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base M03 mock treatment 647570.0 42500.0 0.21 684650.0 107000.0 0.51 0.9426 0.951 612510.0 49251.8157894741 0.575490362368222 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base M04 mock treatment 720130.0 115000.0 0.57 680810.0 104000.0 0.49 1.0954 0.9513 632640.0 69381.8157894741 0.810702421228966 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base M05 mock treatment 349980.0 -255000.0 -1.27 618330.0 41100.0 0.19 0.3091 0.1753 631680.0 68421.8157894741 0.799485154636501 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base M06 mock treatment 695170.0 90100.0 0.45 669970.0 92700.0 0.44 0.6981 0.9656 585320.0 22061.8157894741 0.25778465544206 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base M07 mock treatment 666140.0 61000.0 0.3 656770.0 79500.0 0.37 0.8487 0.9403 591650.0 28391.8157894741 0.331748507036124 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base M08 mock treatment 703160.0 98100.0 0.49 724330.0 147000.0 0.69 0.6561 0.5974 526960.0 -36298.1842105259 -0.42413167615819 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base M09 mock treatment 627760.0 22700.0 0.11 697980.0 121000.0 0.57 0.9838 0.9047 609880.0 46621.8157894741 0.544759725765948 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base M10 mock treatment 675090.0 70000.0 0.35 717700.0 140000.0 0.66 0.8465 0.9312 581210.0 17951.8157894741 0.20976073284307 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base M11 mock treatment 659320.0 54200.0 0.27 677440.0 100000.0 0.47 0.875 0.9653 614570.0 51311.8157894741 0.599560746931219 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base M12 mock treatment 649120.0 44000.0 0.22 686570.0 109000.0 0.51 0.99 0.9351 627410.0 64151.8157894741 0.749591687605434 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base M13 mock treatment 623620.0 18500.0 0.09 648090.0 70800.0 0.33 0.8217 0.8747 606510.0 43251.8157894741 0.505382446165317 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base M14 mock treatment 689790.0 84700.0 0.42 660500.0 83200.0 0.39 1.1921 0.9292 647740.0 84481.8157894741 0.987140677006275 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base M15 mock treatment 725310.0 120000.0 0.6 677610.0 100000.0 0.47 0.7576 0.9144 586560.0 23301.8157894741 0.27227362479066 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base M16 mock treatment 660870.0 55800.0 0.28 660010.0 82700.0 0.39 0.8518 0.9331 591840.0 28581.8157894741 0.333968591049216 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base M17 mock treatment 700860.0 95800.0 0.48 540680.0 -36600.0 -0.17 0.2949 0.5344 570720.0 7461.81578947406 0.0871887260149927 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base M18 mock treatment 660170.0 55100.0 0.28 669320.0 92000.0 0.43 1.0794 0.9235 611710.0 48451.8157894741 0.566142640207834 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base M19 mock treatment 631160.0 26100.0 0.13 586720.0 9440.0 0.04 0.3089 0.7377 567630.0 4371.81578947406 0.0510831491704969 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base M20 mock treatment 350200.0 -255000.0 -1.27 471320.0 -106000.0 -0.5 -0.5903 -0.4089 576520.0 13261.8157894741 0.1549597116778 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base M21 mock treatment 627570.0 22500.0 0.11 497000.0 -80300.0 -0.38 0.0206 0.0458 576430.0 13171.8157894741 0.153908092934757 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base M22 mock treatment 585370.0 -19700.0 -0.1 446880.0 -130000.0 -0.61 -0.3705 -0.5864 568860.0 5601.81578947406 0.0654552719920923 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base M23 mock treatment 595620.0 -9480.0 -0.05 288340.0 -289000.0 -1.36 0.1283 0.0701 614250.0 50991.8157894741 0.595821658067064 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base M24 mock treatment 618740.0 13600.0 0.07 458210.0 -119000.0 -0.56 -0.3606 -0.6041 546880.0 -16378.1842105259 -0.191373394364547 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base N01 mock treatment 561840.0 -43300.0 -0.22 561550.0 -15700.0 -0.07 -0.0801 -0.3211 566400.0 3141.81578947406 0.0367110263489015 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base N02 mock treatment 549670.0 -55400.0 -0.28 543160.0 -34100.0 -0.16 0.0495 0.0903 572160.0 8901.81578947406 0.10401462590369 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base N03 mock treatment 636190.0 31100.0 0.16 641440.0 64200.0 0.3 0.5917 0.9602 596040.0 32781.8157894741 0.383044132391249 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base N04 mock treatment 699520.0 94400.0 0.47 634720.0 57400.0 0.27 0.8526 0.9768 601550.0 38291.8157894741 0.447426568770916 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base N05 mock treatment 640850.0 35700.0 0.18 560420.0 -16900.0 -0.08 0.6776 0.745 618020.0 54761.8157894741 0.639872798747889 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base N06 mock treatment 559210.0 -45900.0 -0.23 605220.0 27900.0 0.13 -0.3937 -0.4634 572690.0 9431.81578947406 0.110207491834946 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base N07 mock treatment 655740.0 50600.0 0.25 676480.0 99200.0 0.47 0.6293 0.9626 585120.0 21861.8157894741 0.255447724901963 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base N08 mock treatment 621290.0 16200.0 0.08 593520.0 16200.0 0.08 0.1063 0.1566 606080.0 42821.8157894741 0.500358045504109 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base N09 mock treatment 599150.0 -5950.0 -0.03 634890.0 57600.0 0.27 0.3602 0.8016 590610.0 27351.8157894741 0.319596468227621 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base N10 mock treatment 560100.0 -45000.0 -0.22 606420.0 29100.0 0.14 0.5296 0.5725 634050.0 70791.8157894741 0.827177781536648 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base N11 mock treatment 359060.0 -246000.0 -1.23 634030.0 56800.0 0.27 -0.331 -0.2594 579100.0 15841.8157894741 0.185106115645049 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base N12 mock treatment 594740.0 -10400.0 -0.05 563900.0 -13400.0 -0.06 0.212 0.4972 596800.0 33541.8157894741 0.391924468443617 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base N13 mock treatment 672130.0 67000.0 0.33 464370.0 -113000.0 -0.53 0.2478 0.3092 598560.0 35301.8157894741 0.412489457196469 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base N14 mock treatment 671160.0 66100.0 0.33 517520.0 -59800.0 -0.28 0.206 0.4048 574400.0 11141.8157894741 0.130188247952774 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base N15 mock treatment 568860.0 -36200.0 -0.18 599400.0 22100.0 0.1 0.024 0.0334 609800.0 46541.8157894741 0.54382495354991 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base N16 mock treatment 635880.0 30800.0 0.15 382280.0 -195000.0 -0.92 -0.0439 -0.0414 581710.0 18451.8157894741 0.215603059193312 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base N17 mock treatment 585970.0 -19100.0 -0.1 609610.0 32300.0 0.15 0.6748 0.7222 614470.0 51211.8157894741 0.59839228166117 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base N18 mock treatment 622630.0 17500.0 0.09 602010.0 24700.0 0.12 0.3522 0.8462 574770.0 11511.8157894741 0.134511569451953 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base N19 mock treatment 383550.0 -222000.0 -1.11 580490.0 3210.0 0.02 -0.6991 -0.6069 535910.0 -27348.1842105259 -0.319554034488858 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base N20 mock treatment 583110.0 -22000.0 -0.11 302240.0 -275000.0 -1.29 -0.5309 -0.3999 586160.0 22901.8157894741 0.267599763710467 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base N21 mock treatment 585600.0 -19500.0 -0.1 374990.0 -202000.0 -0.95 -0.8107 -0.7799 541370.0 -21888.1842105259 -0.255755830744215 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base N22 mock treatment 563160.0 -41900.0 -0.21 231160.0 -346000.0 -1.63 -0.9735 -0.5833 540910.0 -22348.1842105259 -0.261130770986437 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base N23 mock treatment 523900.0 -81200.0 -0.41 285190.0 -292000.0 -1.37 -1.0216 -0.7045 559720.0 -3538.18421052594 -0.041342453690332 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base N24 mock treatment 526840.0 -78300.0 -0.39 436600.0 -141000.0 -0.66 -0.704 -0.8521 537760.0 -25498.1842105259 -0.297937426992962 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base O01 mock treatment 552340.0 -52800.0 -0.26 600800.0 23500.0 0.11 0.2636 0.3069 552910.0 -10348.1842105259 -0.120914938580628 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base O02 mock treatment 673990.0 68900.0 0.34 639520.0 62200.0 0.29 0.577 0.7844 558100.0 -5158.18421052594 -0.0602715910651162 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base O03 mock treatment 673800.0 68700.0 0.34 668060.0 90800.0 0.43 0.7858 0.9963 599300.0 36041.8157894741 0.421136100194827 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base O04 mock treatment 609460.0 4360.0 0.02 632280.0 55000.0 0.26 0.6825 0.8329 602000.0 38741.8157894741 0.452684662486134 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base O05 mock treatment 661820.0 56700.0 0.28 621440.0 44200.0 0.21 0.2879 0.5276 541880.0 -21378.1842105259 -0.249796657866968 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base O06 mock treatment 689960.0 84900.0 0.42 578530.0 1250.0 0.01 0.7961 0.823 595850.0 32591.8157894741 0.380824048378157 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base O07 mock treatment 645160.0 40100.0 0.2 640400.0 63100.0 0.3 1.0714 0.8518 614590.0 51331.8157894741 0.599794439985228 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base O08 mock treatment 589780.0 -15300.0 -0.08 628980.0 51700.0 0.24 0.3433 0.4837 552160.0 -11098.1842105259 -0.129678428105992 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base O09 mock treatment 678090.0 73000.0 0.36 623480.0 46200.0 0.22 0.8977 0.8477 642590.0 79331.8157894741 0.926964715598782 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base O10 mock treatment 705310.0 100000.0 0.5 625600.0 48300.0 0.23 0.7712 0.8504 571840.0 8581.81578947406 0.100275537039535 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base O11 mock treatment 645160.0 40100.0 0.2 575330.0 -1950.0 -0.01 0.3761 0.783 576270.0 13011.8157894741 0.152038548502679 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base O12 mock treatment 642310.0 37200.0 0.19 662780.0 85500.0 0.4 1.0719 0.8958 620190.0 56931.8157894741 0.665228495107939 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base O13 mock treatment 248810.0 -356000.0 -1.78 557240.0 -20000.0 -0.09 -0.2195 -0.1062 608760.0 45501.8157894741 0.531672914741406 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base O14 mock treatment 636530.0 31400.0 0.16 700030.0 123000.0 0.58 1.1817 0.8699 608740.0 45481.8157894741 0.531439221687397 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base O15 mock treatment 683450.0 78300.0 0.39 647380.0 70100.0 0.33 0.9834 0.9081 594340.0 31081.8157894741 0.363180222800426 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base O16 mock treatment 658950.0 53800.0 0.27 679840.0 103000.0 0.48 0.6819 0.9714 590320.0 27061.8157894741 0.31620791894448 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base O17 mock treatment 663640.0 58500.0 0.29 499070.0 -78200.0 -0.37 0.7671 0.6152 620250.0 56991.8157894741 0.665929574269968 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base O18 mock treatment 592030.0 -13100.0 -0.07 457510.0 -120000.0 -0.56 0.2745 0.2713 608090.0 44831.8157894741 0.523844197432082 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base O19 mock treatment 296400.0 -309000.0 -1.54 573020.0 -4260.0 -0.02 -0.0377 -0.0193 592610.0 29351.8157894741 0.342965773628589 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base O20 mock treatment 531150.0 -74000.0 -0.37 459240.0 -118000.0 -0.56 0.2292 0.1926 629820.0 66561.8157894741 0.777751700613601 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base O21 mock treatment 546880.0 -58200.0 -0.29 529720.0 -47600.0 -0.22 0.3481 0.3537 634300.0 71041.8157894741 0.830098944711769 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base O22 mock treatment 499450.0 -106000.0 -0.53 213280.0 -364000.0 -1.71 -0.6897 -0.3497 566430.0 3171.81578947406 0.037061565929916 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base O23 mock treatment 581340.0 -23800.0 -0.12 357570.0 -220000.0 -1.03 -0.047 -0.0328 647640.0 84381.8157894741 0.985972211736227 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base O24 mock treatment 514630.0 -90500.0 -0.45 529220.0 -48100.0 -0.23 -0.5138 -0.8258 564390.0 1131.81578947406 0.0132248744209286 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base P01 mock treatment 584510.0 -20600.0 -0.1 538560.0 -38700.0 -0.18 -0.4746 -0.9025 528160.0 -35098.1842105259 -0.410110092917609 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base P02 mock treatment 550560.0 -54500.0 -0.27 362690.0 -215000.0 -1.01 -0.9988 -0.8595 534730.0 -28528.1842105259 -0.333341924675429 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base P03 mock treatment 541090.0 -64000.0 -0.32 519000.0 -58300.0 -0.27 -0.7136 -0.9708 520000.0 -43258.1842105259 -0.505456858953559 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base P04 mock treatment 577330.0 -27800.0 -0.14 194120.0 -383000.0 -1.8 -1.3496 -0.6916 500370.0 -62888.1842105259 -0.734826591464061 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base P05 mock treatment 544760.0 -60300.0 -0.3 206880.0 -370000.0 -1.74 -1.3615 -0.7373 548070.0 -15188.1842105259 -0.177468657650971 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base P06 mock treatment 549760.0 -55300.0 -0.28 186100.0 -391000.0 -1.84 -1.2384 -0.6592 550680.0 -12578.1842105259 -0.146971714102708 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base P07 mock treatment 521490.0 -83600.0 -0.42 406760.0 -171000.0 -0.8 -1.3059 -0.7873 563120.0 -138.184210525942 -0.00161463450868621 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base P08 mock treatment 529690.0 -75400.0 -0.38 517180.0 -60100.0 -0.28 -0.4788 -0.808 568130.0 4871.81578947406 0.0569254755207389 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base P09 mock treatment 573860.0 -31200.0 -0.16 338120.0 -239000.0 -1.12 -1.0971 -0.727 478480.0 -84778.1842105259 -0.990603639077657 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base P10 mock treatment 324710.0 -280000.0 -1.4 279520.0 -298000.0 -1.4 -1.8977 -0.9028 522980.0 -40278.1842105259 -0.470636593906116 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base P11 mock treatment 267260.0 -338000.0 -1.69 503530.0 -73700.0 -0.35 -1.9305 -0.8487 440710.0 -122548.184210526 -1.43193297157494 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base P12 mock treatment 493200.0 -112000.0 -0.56 366680.0 -211000.0 -0.99 -1.442 -0.8828 464050.0 -99208.1842105259 -1.15921317754564 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base P13 mock treatment 440160.0 -165000.0 -0.82 529380.0 -47900.0 -0.23 -1.224 -0.9296 493690.0 -69568.1842105259 -0.812880071503295 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base P14 mock treatment 537640.0 -67500.0 -0.34 387360.0 -190000.0 -0.89 -0.9416 -0.8421 556760.0 -6498.18421052594 -0.0759290256837648 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base P15 mock treatment 526900.0 -78200.0 -0.39 327450.0 -250000.0 -1.18 -1.1166 -0.8231 552240.0 -11018.1842105259 -0.128743655889953 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base P16 mock treatment 237970.0 -367000.0 -1.83 296500.0 -281000.0 -1.32 -2.1136 -0.8812 501200.0 -62058.1842105259 -0.725128329722659 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base P17 mock treatment 527860.0 -77200.0 -0.39 266300.0 -311000.0 -1.46 -1.4136 -0.8072 554520.0 -8738.18421052594 -0.102102647732849 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base P18 mock treatment 543950.0 -61200.0 -0.31 252450.0 -325000.0 -1.53 -1.7175 -0.8844 479840.0 -83418.1842105259 -0.974712511404999 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base P19 mock treatment 341630.0 -263000.0 -1.32 196480.0 -381000.0 -1.79 -2.28 -0.9275 514260.0 -48998.1842105259 -0.572526765454337 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base P20 mock treatment 223270.0 -382000.0 -1.91 301680.0 -276000.0 -1.3 -2.6793 -0.961 493120.0 -70138.1842105259 -0.81954032354257 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base P21 mock treatment 223450.0 -382000.0 -1.91 333040.0 -244000.0 -1.15 -2.3085 -0.9275 505290.0 -57968.1842105259 -0.677338100177679 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base P22 mock treatment 365640.0 -239000.0 -1.2 266630.0 -311000.0 -1.46 -1.6912 -0.8626 524810.0 -38448.1842105259 -0.449253679464231 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base P23 mock treatment 187200.0 -418000.0 -2.09 195040.0 -382000.0 -1.8 -2.0987 -0.7594 549120.0 -14138.1842105259 -0.165199772315463 1001.0071 CellTiterGlo(1001.0071) MODYPatientCellProfiling 1001.0071.Base P24 mock treatment 296390.0 -309000.0 -1.54 466570.0 -111000.0 -0.52 -2.9146 -0.8963 457280.0 -105978.184210526 -1.23831827632792