# go

id: GO:0003322
name: pancreatic A cell development
namespace: biological_process
def:
  "The process whose specific outcome is the progression of a pancreatic A cell over time, from its formation to the mature structure. A pancreatic A cell is a cell in the pancreas that secretes glucagon." [GOC:dph]


id: GO:0003323
name: type B pancreatic cell development
namespace: biological_process
def:
  "The process whose specific outcome is the progression of a type B pancreatic cell over time, from its formation to the mature structure. A type B pancreatic cell is a cell located towards center of the islets of Langerhans that secretes insulin." [CL:0000169, GOC:dph]


id: GO:0003324
name: pancreatic D cell development
namespace: biological_process
def:
  "The process whose specific outcome is the progression of a pancreatic delta cell over time, from its formation to the mature structure. A delta cell is a cell of the pancreas that produces somatostatin." [GOC:dph]


id: GO:0003325
name: pancreatic PP cell development
namespace: biological_process
def:
  "The process whose specific outcome is the progression of a pancreatic PP cell over time, from its formation to the mature structure. A pancreatic polypeptide-producing cell is a cell in the pancreas that produces pancreatic polypeptide." [GOC:dph]


id: GO:0003326
name: pancreatic A cell fate commitment
namespace: biological_process
def:
  "The commitment of a cell to a pancreatic A cell and its capacity to differentiate into a pancreatic A cell. A pancreatic A cell is a cell in the pancreas that secretes glucagon." [GOC:dph]


id: GO:0003327
name: type B pancreatic cell fate commitment
namespace: biological_process
def:
  "The commitment of a cell to a type B pancreatic cell fate and its capacity to differentiate into a type B pancreatic cell. A type B pancreatic cell is a cell located towards center of the islets of Langerhans that secretes insulin." [CL:0000169, GOC:dph]


id: GO:0003328
name: pancreatic D cell fate commitment
namespace: biological_process
def:
  "The commitment of a cell to a pancreatic D cell fate and its capacity to differentiate into a pancreatic D cell. A delta cell is a cell of the pancreas that produces somatostatin." [GOC:dph]


id: GO:0003329
name: pancreatic PP cell fate commitment
namespace: biological_process
def:
  "The commitment of a cell to a pancreatic PP cell fate and its capacity to differentiate into a pancreatic PP cell. A pancreatic polypeptide-producing cell is a cell in the pancreas that produces pancreatic polypeptide." [GOC:dph]


id: GO:0003330
name: regulation of extracellular matrix constituent secretion
namespace: biological_process
def:
  "Any process that modulates the rate, frequency, or extent of the controlled release of molecules that form the extracellular matrix, including carbohydrates and glycoproteins by a cell or a group of cells." [GOC:dph, GOC:tb]


id: GO:0003331
name: positive regulation of extracellular matrix constituent secretion
namespace: biological_process
def:
  "Any process that increases the rate, frequency, or extent of the controlled release of molecules that form the extracellular matrix, including carbohydrates and glycoproteins by a cell or a group of cells." [GOC:dph, GOC:tb]


id: GO:0003332
name: negative regulation of extracellular matrix constituent secretion
namespace: biological_process
def:
  "Any process that decreases the rate, frequency, or extent the controlled release of molecules that form the extracellular matrix, including carbohydrates and glycoproteins by a cell or a group of cells." [GOC:dph, GOC:tb]


id: GO:0003333
name: amino acid transmembrane transport
namespace: biological_process
def:
  "The directed movement of amino acids, organic acids containing one or more amino substituents across a membrane by means of some agent such as a transporter or pore." [GOC:dph, GOC:tb]


id: GO:0003334
name: keratinocyte development
namespace: biological_process
def:
  "The process whose specific outcome is the progression of a keratinocyte over time, from its formation to the mature structure." [GOC:dph]


id: GO:0003335
name: corneocyte development
namespace: biological_process
def:
  "The process whose specific outcome is the progression of the corneocyte over time, from its formation to the mature structure. A corneocyte is the last stage of development of a keratinocyte where the keratinocyte flattens, loses its nucleus and eventually delaminates from the epidermis." [GOC:dph]


id: GO:0003336
name: corneocyte desquamation
namespace: biological_process
def:
  "The delamination process that results in the shedding of a corneocyte from the surface of the epidermis." [GOC:dph]


id: GO:0003337
name: mesenchymal to epithelial transition involved in metanephros morphogenesis
namespace: biological_process
def:
  "A transition where a mesenchymal cell establishes apical/basolateral polarity,forms intercellular adhesive junctions, synthesizes basement membrane components and becomes an epithelial cell that will contribute to the shaping of the metanephros." [GOC:dph, GOC:yaf]


id: GO:0003338
name: metanephros morphogenesis
namespace: biological_process
def:
  "The process in which the anatomical structures of the metanephros are generated and organized." [GOC:dph, GOC:yaf]


id: GO:0003339
name: regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis
namespace: biological_process
def:
  "Any process that modulates the rate, frequency or extent of the transition where a mesenchymal cell establishes apical/basolateral polarity,forms intercellular adhesive junctions, synthesizes basement membrane components and becomes an epithelial cell that will contribute to the shaping of the metanephros." [GOC:dph]


id: GO:0003340
name: negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis
namespace: biological_process
def:
  "Any process that decreases the rate, frequency or extent of the transition where a mesenchymal cell establishes apical/basolateral polarity,forms intercellular adhesive junctions, synthesizes basement membrane components and becomes an epithelial cell that will contribute to the shaping of the metanephros." [GOC:dph, GOC:yaf]


id: GO:0003342
name: proepicardium development
namespace: biological_process
def:
  "The progression of the proepicardium from its formation to the mature structure. The proepicardium is an outpouching of the septum transversum." [GOC:dph, PMID:18722343]


id: GO:0003343
name: septum transversum development
namespace: biological_process
def:
  "The progression of the septum transversum from its initial formation to the mature structure. The septum transversum is a portion of the trunk mesenchyme." [GOC:dph, PMID:18722343]


id: GO:0003344
name: pericardium morphogenesis
namespace: biological_process
def:
  "The process in which the anatomical structure of the pericardium is generated and organized." [GOC:dph, PMID:18722343]


id: GO:0003345
name: proepicardium cell migration involved in pericardium morphogenesis
namespace: biological_process
def:
  "The coordinated movement of a mesenchymal proepicardial cell to the surface of the developing heart." [GOC:dph, PMID:18722343]


id: GO:0003346
name: epicardium-derived cell migration to the myocardium
namespace: biological_process
def:
  "The orderly movement of a cell that have undergone an epithelial to mesenchymal transition from the epicardium into the myocardium." [GOC:dph, PMID:18722343]


id: GO:0003347
name: epicardial cell to mesenchymal cell transition
namespace: biological_process
def:
  "A transition where an epicardial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell. The epicardium is a part of the pericardium." [GOC:dph, PMID:18722343]


id: GO:0003348
name: cardiac endothelial cell differentiation
namespace: biological_process
def:
  "The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a cardiac endothelial cell." [GOC:dph, PMID:18722343]


id: GO:0003349
name: epicardium-derived cardiac endothelial cell differentiation
namespace: biological_process
def:
  "The process in which an epicardial cell acquires the specialized structural and/or functional features of a cardiac endothelial cell." [GOC:dph, PMID:18722343]


id: GO:0003350
name: pulmonary myocardium development
namespace: biological_process
def:
  "The progression of the pulmonary myocardium over time, from its initial formation to the mature structure. The pulmonary myocardium is the myocardial tissue present in the pulmonary vein." [GOC:dph, PMID:17638577]


id: GO:0003351
name: epithelial cilium movement
namespace: biological_process
def:
  "The directed, self-propelled movement of a cilium of an epithelial cell. This movement is usually coordinated between many epithelial cells, and serves to move fluid." [GOC:dph]


id: GO:0003352
name: regulation of cilium movement
namespace: biological_process
def:
  "Any process that modulates the rate, frequency, or extent of cilium movement, the directed, self-propelled movement of a cilium." [GOC:dph]


id: GO:0003353
name: positive regulation of cilium movement
namespace: biological_process
def:
  "Any process that increases the rate, frequency, or extent of cilium movement, the directed, self-propelled movement of a cilium." [GOC:dph]


id: GO:0003354
name: negative regulation of cilium movement
namespace: biological_process
def:
  "Any process that decreases the rate, frequency, or extent of cilium movement, the directed, self-propelled movement of a cilium." [GOC:dph]


id: GO:0003355
name: cilium movement involved in otolith formation
namespace: biological_process
def:
  "The directed, self-propelled movement of a cilium of an inner ear epithelial cell, resulting the aggregation of otolith seed particles." [GOC:dph]


id: GO:0003356
name: regulation of cilium beat frequency
namespace: biological_process
def:
  "Any process that modulates the frequency of cilium movement, the directed, self-propelled movement of a cilium." [GOC:dph]


id: GO:0003357
name: noradrenergic neuron differentiation
namespace: biological_process
def:
  "The process in which a relatively unspecialized cell acquires specialized features of an noradrenergic neuron, a neuron that secretes noradrenaline." [GOC:dph]


id: GO:0003358
name: noradrenergic neuron development
namespace: biological_process
def:
  "The process whose specific outcome is the progression of a noradrenergic neuron over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell." [GOC:dph]


id: GO:0003359
name: noradrenergic neuron fate commitment
namespace: biological_process
def:
  "The process in which the developmental fate of a cell becomes restricted such that it will develop into a noradrenergic neuron." [GOC:dph]


id: GO:0003360
name: brainstem development
namespace: biological_process
def:
  "The progression of the brainstem from its formation to the mature structure. The brainstem is the part of the brain that connects the brain with the spinal cord." [GOC:dph]


id: GO:0003361
name: noradrenergic neuron differentiation involved in brainstem development
namespace: biological_process
def:
  "The process in which a relatively unspecialized cell acquires specialized features of an noradrenergic neuron that is part of the brainstem." [GOC:dph]


id: GO:0003362
name: noradrenergic neuron fate commitment involved in brainstem development
namespace: biological_process
def:
  "The process in which the developmental fate of a cell becomes restricted such that it will develop into a noradrenergic neuron that is part of the brainstem." [GOC:dph]


id: GO:0003363
name: lamellipodium assembly involved in ameboidal cell migration
namespace: biological_process
def:
  "Formation of a lamellipodium, a thin sheetlike extension of the surface of a migrating cell that contributes to the directed self propelled movement of a cell." [GOC:ascb_2009, GOC:dph, GOC:tb]


id: GO:0003364
name: lamellipodium assembly involved in mesendodermal cell migration
namespace: biological_process
def:
  "Formation of a lamellipodium, a thin sheetlike extension of the surface of a migrating cell that contributes to the directed self-propelled movement of a mesendodermal cell." [GOC:ascb_2009, GOC:dph, GOC:tb]


id: GO:0003365
name: establishment of cell polarity involved in ameboidal cell migration
namespace: biological_process
def:
  "The specification and formation of anisotropic intracellular organization that contributes to the self-propelled directed movement of an ameboid cell." [GOC:ascb_2009, GOC:dph, GOC:tb]


id: GO:0003366
name: cell-matrix adhesion involved in ameboidal cell migration
namespace: biological_process
def:
  "The binding of a cell to the extracellular matrix that contributes to the directed movement of an ameboid cell." [GOC:ascb_2009, GOC:dph, GOC:tb]


id: GO:0003367
name: cell-cell adhesion involved in ameboidal cell migration
namespace: biological_process
def:
  "The attachment of one ameboid cell to another that contributes to the establishment of cell polarity that is part of the directed movement of one of the cells." [GOC:ascb_2009, GOC:dph, GOC:tb]


id: GO:0003368
name: cell-matrix adhesion involved in mesendodermal cell migration
namespace: biological_process
def:
  "The binding of a cell to the extracellular matrix that contributes to the directed movement of a mesendodermal cell." [GOC:ascb_2009, GOC:dph, GOC:tb]


id: GO:0003369
name: establishment of cell polarity involved in mesendodermal cell migration
namespace: biological_process
def:
  "The specification and formation of anisotropic intracellular organization that contributes to the self-propelled directed movement of a mesendodermal cell." [GOC:ascb_2009, GOC:dph, GOC:tb]


id: GO:0003370
name: cell-cell adhesion involved in mesendodermal cell migration
namespace: biological_process
def:
  "The attachment of mesendodermal cells to each other that contributes to the establishment of cell polarity that is part of the directed movement of the cells of the mesendoderm." [GOC:ascb_2009, GOC:dph, GOC:tb]


id: GO:0003371
name: establishment or maintenance of cytoskeleton polarity involved in ameboidal cell migration
namespace: biological_process
def:
  "Any cellular process that results in the specification, formation or maintenance of polarized cytoskeletal structures that contribute to the cell polarity of a migrating ameboid cell." [GOC:ascb_2009, GOC:dph, GOC:tb]


id: GO:0003373
name: dynamin polymerization involved in membrane fission
namespace: biological_process
def:
  "The process of creating dynamin polymers, compounds composed of a large number of dynamin monomers. Dynamin polymers form around lipid tubes and contribute to membrane fission." [GOC:ascb_2009, GOC:dph, GOC:tb]


id: GO:0003374
name: dynamin polymerization involved in mitochondrial fission
namespace: biological_process
def:
  "The process of creating dynamin polymers, compounds composed of a large number of dynamin monomers around a lipid tube of a dividing mitochondrion. Dynamin polymers form around lipid tubes and contribute to membrane fission." [GOC:ascb_2009, GOC:dph, GOC:tb]


id: GO:0003375
name: regulation of dynamin polymerization involved in membrane fission
namespace: biological_process
def:
  "Any process that modulates the rate, frequency, or extent of membrane fission." [GOC:ascb_2009, GOC:dph, GOC:tb]


id: GO:0003376
name: sphingosine-1-phosphate signaling pathway
namespace: biological_process
def:
  "A series of molecular signals initiated by the sphingolipid sphingosine-1-phosphate (S1P) binding to a receptor on the surface of the cell, and which proceeds with the activated receptor transmitting the signal by promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The pathway ends with regulation of a downstream cellular process, e.g. transcription." [GOC:ascb_2009, GOC:signaling, PMID:22001186, Reactome:REACT_18416.2]


id: GO:0003377
name: regulation of apoptosis by sphingosine-1-phosphate signaling pathway
namespace: biological_process
def:
  "A sphingosine-1-phosphate signaling pathway that modulates the rate, frequency, or extent of apoptosis." [GOC:ascb_2009, GOC:dph, GOC:signaling, GOC:tb]


id: GO:0003378
name: regulation of inflammatory response by sphingosine-1-phosphate signaling pathway
namespace: biological_process
def:
  "A sphingosine-1-phosphate signaling pathway that modulates the rate, frequency, or extent of the inflammatory response." [GOC:ascb_2009, GOC:dph, GOC:tb]


id: GO:0003379
name: establishment of cell polarity involved in gastrulation cell migration
namespace: biological_process
def:
  "The specification and formation of anisotropic intracellular organization that contributes to the self-propelled directed movement of an ameboid cell taking part in gastrulation." [GOC:ascb_2009, GOC:dph, GOC:tb]


id: GO:0003380
name: establishment or maintenance of cytoskeleton polarity involved in gastrulation
namespace: biological_process
def:
  "Any cellular process that results in the specification, formation or maintenance of polarized cytoskeletal structures that contribute to the cell polarity of a migrating ameboid cell taking part in gastrulation." [GOC:ascb_2009, GOC:dph, GOC:tb]


id: GO:0003381
name: epithelial cell morphogenesis involved in gastrulation
namespace: biological_process
def:
  "The change in form that occurs when an epithelial cell progresses from it initial formation to its mature state, contributing to the process of gastrulation." [GOC:ascb_2009, GOC:dph, GOC:tb]


id: GO:0003382
name: epithelial cell morphogenesis
namespace: biological_process
def:
  "The change in form that occurs when an epithelial cell progresses from its initial formation to its mature state." [GOC:ascb_2009, GOC:dph, GOC:tb]


id: GO:0003383
name: apical constriction
namespace: biological_process
def:
  "The actin-mediated process that results in the contraction of the apical end of a polarized columnar epithelial cell." [GOC:ascb_2009, GOC:dph, GOC:tb]


id: GO:0003384
name: apical constriction involved in gastrulation
namespace: biological_process
def:
  "The actin-mediated process that results in the contraction of the apical end of a polarized columnar epithelial cell, contributing to the process of gastrulation." [GOC:ascb_2009, GOC:dph, GOC:tb]


id: GO:0003385
name: cell-cell signaling involved in amphid sensory organ development
namespace: biological_process
def:
  "Any process that mediates the transfer of information from one cell to another and contributes to the progression of an amphid sensory organ over time, from its formation to the mature state." [GOC:ascb_2009, GOC:dph, GOC:tb]


id: GO:0003386
name: amphid sensory organ development
namespace: biological_process
def:
  "The progression of the amphid sensory organ over time, from its formation to the mature structure. Amphid sensory organs are the sensory organs of nematodes." [GOC:ascb_2009, GOC:dph, GOC:tb]


id: GO:0003387
name: neuron differentiation involved in amphid sensory organ development
namespace: biological_process
def:
  "The process in which a relatively unspecialized cell acquires specialized features of a neuron that contributes to the progression of the amphid sensory gland." [GOC:ascb_2009, GOC:dph, GOC:tb]


id: GO:0003388
name: neuron development involved in amphid sensory organ development
namespace: biological_process
def:
  "The process whose specific outcome is the progression of a neuron over time, that contributes to the development of the amphid sensory organ." [GOC:ascb_2009, GOC:dph, GOC:tb]


id: GO:0003389
name: retrograde extension
namespace: biological_process
def:
  "The progression of a neuronal projection over time by the attachment of a part of the cell to an anchor and the subsequent migration of the cell body away from the anchor point." [GOC:ascb_2009, GOC:dph, GOC:tb]


id: GO:0003390
name: dendrite development by retrograde extension
namespace: biological_process
def:
  "The progression of a dendrite over time by the attachment of a part of the neuron to an anchor and the subsequent migration of the cell body away from the anchor point." [GOC:ascb_2009, GOC:dph, GOC:tb]


id: GO:0003391
name: amphid sensory organ dendrite retrograde extension
namespace: biological_process
def:
  "The progression of an amphid sensory organ's neuronal dendrite over time by the attachment of a part of the cell to an anchor and the subsequent migration of the cell body away from the anchor point." [GOC:ascb_2009, GOC:dph, GOC:tb]


id: GO:0003392
name: cell adhesion involved in retrograde extension
namespace: biological_process
def:
  "The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix that contributes to the process of retrograde extension." [GOC:ascb_2009, GOC:dph, GOC:tb]


id: GO:0003393
name: neuron migration involved in retrograde extension
namespace: biological_process
def:
  "The directed, self-propelled movement of a neuron that contributes to the process of retrograde extension." [GOC:ascb_2009, GOC:dph, GOC:tb]


id: GO:0003394
name: cell adhesion involved in dendrite retrograde extension
namespace: biological_process
def:
  "The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix that contributes to the process of retrograde extension of a dendrite." [GOC:ascb_2009, GOC:dph, GOC:tb]


id: GO:0003395
name: neuron migration involved in dendrite retrograde extension
namespace: biological_process
def:
  "The directed, self-propelled movement of a neuron that contributes to the process of retrograde extension of a dendrite." [GOC:ascb_2009, GOC:dph, GOC:tb]


id: GO:0003396
name: cell adhesion involved in amphid sensory organ dendrite retrograde extension
namespace: biological_process
def:
  "The directed, self-propelled movement of a neuron that contributes to the process of retrograde extension of a dendrite in a neuron of the amphid sensory organ." [GOC:ascb_2009, GOC:dph, GOC:tb]


id: GO:0003397
name: neuron migration involved in amphid sensory organ dendrite retrograde extension
namespace: biological_process
def:
  "The directed, self-propelled movement of a neuron that contributes to the process of retrograde extension of a dendrite of a neuron in the amphid sensory organ." [GOC:ascb_2009, GOC:dph, GOC:tb]


id: GO:0003398
name: glial cell differentiation involved in amphid sensory organ development
namespace: biological_process
def:
  "The process in which a relatively unspecialized cell acquires the specialized features of a glial cell of the amphid sensory organ." [GOC:ascb_2009, GOC:dph, GOC:tb]


id: GO:0003399
name: cytoneme morphogenesis
namespace: biological_process
def:
  "The process in which the anatomical structures of a cytoneme are shaped. A cytoneme is a long, thin and polarized actin-based cytoplasmic extension that projects from a cell." [GOC:ascb_2009, GOC:dph, GOC:tb]


id: GO:0003400
name: regulation of COPII vesicle coating
namespace: biological_process
def:
  "Any process that modulates the rate, frequency, or extent of the addition of COPII proteins and adaptor proteins to ER membranes during the formation of transport vesicles, forming a vesicle coat." [GOC:ascb_2009, GOC:dph, GOC:jp, GOC:tb]


id: GO:0003401
name: axis elongation
namespace: biological_process
def:
  "The developmental growth that results in the elongation of a line that defines polarity or symmetry in an anatomical structure." [GOC:ascb_2009, GOC:dph, GOC:tb]


id: GO:0003402
name: planar cell polarity pathway involved in axis elongation
namespace: biological_process
def:
  "The series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell where activated receptors signal to modulate cytoskeletal elements and control cell polarity that contributes to axis elongation." [GOC:ascb_2009, GOC:dph, GOC:tb]


id: GO:0003403
name: optic vesicle formation
namespace: biological_process
def:
  "The developmental process pertaining to the initial formation of the optic vesicle from the lateral wall of the forebrain. This process begins with the specific processes that contribute to the appearance of the vesicle and ends when the vesicle has evaginated. The optic vesicle is the evagination of neurectoderm that precedes formation of the optic cup." [GOC:ascb_2009, GOC:dph, GOC:tb]


id: GO:0003404
name: optic vesicle morphogenesis
namespace: biological_process
def:
  "The developmental process pertaining to the formation and shaping of the optic vesicle. This process begins with the specific processes that contribute to the appearance of the vesicle and ends when the vesicle has evaginated. The optic vesicle is the evagination of neurectoderm that precedes formation of the optic cup." [GOC:ascb_2009, GOC:dph, GOC:tb]


id: GO:0003405
name: optic vesicle elongation
namespace: biological_process
def:
  "The developmental growth that results in the lengthening of the optic vesicle in the posterior direction." [GOC:ascb_2009, GOC:dph, GOC:tb]


id: GO:0003406
name: retinal pigment epithelium development
namespace: biological_process
def:
  "The progression of the retinal pigment epithelium over time, from its initial formation to the mature structure. The retinal pigment epithelium is the melanin-containing layer of cells between the retina and the choroid that absorbs scattered and reflected light and removes waste products produced by the photoreceptor cells." [GOC:ascb_2009, GOC:dph, GOC:tb]


id: GO:0003407
name: neural retina development
namespace: biological_process
def:
  "The progression of the neural retina over time from its initial formation to the mature structure. The neural retina is the part of the retina that contains neurons and photoreceptor cells." [GOC:ascb_2009, GOC:dph, GOC:tb]


id: GO:0003408
name: optic cup formation involved in camera-type eye development
namespace: biological_process
def:
  "The developmental process pertaining to the initial formation of the optic cup, a two-walled vesicle formed from the optic vesicle." [GOC:ascb_2009, GOC:dph, GOC:tb]


id: GO:0003409
name: optic cup structural organization
namespace: biological_process
def:
  "The process that contributes to creating the structural organization of the optic cup. This process pertains to the physical shaping of the rudimentary structure." [GOC:ascb_2009, GOC:dph, GOC:tb]


id: GO:0003410
name: anterior rotation of the optic cup
namespace: biological_process
def:
  "A 90 degree-rotation of the optic cup resulting in its alignment with the anterior-posterior body axis." [GOC:ascb_2009, GOC:dph, GOC:tb]


id: GO:0003411
name: cell motility involved in camera-type eye morphogenesis
namespace: biological_process
def:
  "Any process involved in the controlled self-propelled movement of a cell that results in translocation of the cell from one place to another and contributes to the physical shaping or formation of the camera-type eye." [GOC:ascb_2009, GOC:dph, GOC:tb]


id: GO:0003412
name: establishment of epithelial cell apical/basal polarity involved in camera-type eye morphogenesis
namespace: biological_process
def:
  "The specification and formation of the apicobasal polarity of an epithelial cell that contributes to the shaping of a camera-type eye." [GOC:ascb_2009, GOC:dph, GOC:tb]


id: GO:0003413
name: chondrocyte differentiation involved in endochondral bone morphogenesis
namespace: biological_process
def:
  "The process in which a chondroblast acquires specialized structural and/or functional features of a chondrocyte that will contribute to the development of a bone. A chondrocyte is a polymorphic cell that forms cartilage." [GOC:ascb_2009, GOC:dph, GOC:tb]


id: GO:0003414
name: chondrocyte morphogenesis involved in endochondral bone morphogenesis
namespace: biological_process
def:
  "The process in which the structures of a chondrocyte that will contribute to bone development are generated and organized." [GOC:ascb_2009, GOC:dph, GOC:tb]


id: GO:0003415
name: chondrocyte hypertrophy
namespace: biological_process
def:
  "The growth of a chondrocyte, where growth contributes to the progression of the chondrocyte over time." [GOC:ascb_2009, GOC:dph, GOC:tb]


id: GO:0003416
name: endochondral bone growth
namespace: biological_process
def:
  "The increase in size or mass of an endochondral bone that contributes to the shaping of the bone." [GOC:ascb_2009, GOC:dph, GOC:tb]


id: GO:0003417
name: growth plate cartilage development
namespace: biological_process
def:
  "The process whose specific outcome is the progression of the cartilage that will provide a scaffold for mineralization of endochondral bones as they elongate or grow." [GOC:ascb_2009, GOC:dph, GOC:tb]


id: GO:0003418
name: growth plate cartilage chondrocyte differentiation
namespace: biological_process
def:
  "The process in which a chondroblast acquires specialized structural and/or functional features of a chondrocyte that will contribute to the growth of a bone. A chondrocyte is a polymorphic cell that forms cartilage." [GOC:ascb_2009, GOC:dph, GOC:tb]


id: GO:0003419
name: growth plate cartilage chondrocyte proliferation
namespace: biological_process
def:
  "The multiplication or reproduction of chondrocytes in a growing endochondral bone, resulting in the expansion of a cell population." [GOC:ascb_2009, GOC:dph, GOC:tb]


id: GO:0003420
name: regulation of growth plate cartilage chondrocyte proliferation
namespace: biological_process
def:
  "Any process that modulates the rate, frequency, or extent of the multiplication or reproduction of chondrocytes in a growing endochondral bone, resulting in the expansion of a cell population." [GOC:ascb_2009, GOC:dph, GOC:tb]


id: GO:0003421
name: growth plate cartilage axis specification
namespace: biological_process
def:
  "The establishment, maintenance and elaboration of the columnar cartilage along the axis of a long bone that contributes to bone growth." [GOC:ascb_2009, GOC:dph, GOC:tb]


id: GO:0003422
name: growth plate cartilage morphogenesis
namespace: biological_process
def:
  "The process in which the anatomical structures of cartilage are generated and organized." [GOC:ascb_2009, GOC:dph, GOC:tb]


id: GO:0003423
name: growth plate cartilage chondrocyte division
namespace: biological_process
def:
  "The process resulting in the oriented physical partitioning and separation of a chondrocytes in the growth plate." [GOC:ascb_2009, GOC:dph, GOC:tb]


id: GO:0003424
name: establishment of cell polarity involved in growth plate cartilage chondrocyte division
namespace: biological_process
def:
  "The cellular process that results in the specification, formation or maintenance of anisotropic intracellular organization that results in the directional division of a growth plate cartilage chondrocyte." [GOC:ascb_2009, GOC:dph, GOC:tb]


id: GO:0003425
namespace: biological_process
name:
  establishment of mitotic spindle orientation involved in growth plate cartilage chondrocyte division

def:
  "A cell cycle process that sets the alignment of mitotic spindle relative to other cellular structures and contributes to oriented chondrocyte division in the growth plate." [GOC:ascb_2009, GOC:dph, GOC:tb]


id: GO:0003426
name: cytoskeleton polarization involved in growth plate cartilage chondrocyte division
namespace: biological_process
def:
  "A process that is carried out at the cellular level which results in the polarization of cytoskeletal structures in a growth plate cartilage chondrocyte. This process results in the oriented division of the cell." [GOC:ascb_2009, GOC:dph, GOC:tb]


id: GO:0003427
name: regulation of cytoskeleton polarization involved in growth plate cartilage chondrocyte division
namespace: biological_process
def:
  "The series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell that modulates the rate, frequency, or extent of the polarization of cytoskeletal structures in a growth plate cartilage chondrocyte. This process results in the oriented division of the cell." [GOC:ascb_2009, GOC:dph, GOC:tb]


id: GO:0003428
name: chondrocyte intercalation involved in growth plate cartilage morphogenesis
namespace: biological_process
def:
  "The orderly movement of a chondrocyte from one site to another that contributes to the shaping of growth plate cartilage in an endochondral bone." [GOC:ascb_2009, GOC:dph, GOC:tb]


id: GO:0003429
name: growth plate cartilage chondrocyte morphogenesis
namespace: biological_process
def:
  "The process in which the structures of a chondrocyte in the growth plate cartilage are generated and organized." [GOC:ascb_2009, GOC:dph, GOC:tb]


id: GO:0003430
name: growth plate cartilage chondrocyte growth
namespace: biological_process
def:
  "The growth of a growth plate cartilage chondrocyte, where growth contributes to the progression of the chondrocyte over time from one condition to another." [GOC:ascb_2009, GOC:dph, GOC:tb]


id: GO:0003431
name: growth plate cartilage chondrocyte development
namespace: biological_process
def:
  "The progression of a growth plate cartilage chondrocyte over time from after its fate commitment to the mature cell." [GOC:ascb_2009, GOC:dph, GOC:tb]


id: GO:0003432
name: cell growth involved in growth plate cartilage chondrocyte morphogenesis
namespace: biological_process
def:
  "The growth of a growth plate cartilage chondrocyte, where growth contributes to the shaping of the chondrocyte over time." [GOC:ascb_2009, GOC:dph, GOC:tb]


id: GO:0003433
name: chondrocyte development involved in endochondral bone morphogenesis
namespace: biological_process
def:
  "The progression of a chondrocyte over time from after its commitment to its mature state where the chondrocyte will contribute to the shaping of an endochondral bone." [GOC:ascb_2009, GOC:dph, GOC:tb]


id: GO:0003434
name: BMP signaling pathway involved in growth plate cartilage chondrocyte development
namespace: biological_process
def:
  "A series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, which contributes to the progression of a growth plate cartilage chondrocyte over time." [GOC:ascb_2009, GOC:dph, GOC:tb]


id: GO:0003435
name: smoothened signaling pathway involved in growth plate cartilage chondrocyte development
namespace: biological_process
def:
  "The series of molecular signals generated as a consequence of activation of the transmembrane protein Smoothened that contributes to the progression of a growth plate cartilage chondrocyte over time." [GOC:ascb_2009, GOC:dph, GOC:tb]


id: GO:0003436
name: regulation of cell adhesion involved in growth plate cartilage morphogenesis
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of attachment of a cell to another cell or to the extracellular matrix and contributes to the shaping of the growth plate cartilage of an endochondral bone." [GOC:ascb_2009, GOC:dph, GOC:tb]


id: GO:0003437
name: regulation of cell communication involved in growth plate cartilage morphogenesis
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of cell communication that contributes to the shaping of the growth plate cartilage." [GOC:ascb_2009, GOC:dph, GOC:tb]


id: GO:0003673
name: obsolete Gene_Ontology
namespace: biological_process
def:
  "OBSOLETE. A controlled vocabulary that can be applied to all organisms even as knowledge of gene and protein roles in cells is accumulating and changing. GO provides three structured networks of defined terms to describe gene product attributes." [GOC:go_curators]


id: GO:0003674
name: molecular_function
namespace: molecular_function
def:
  "Elemental activities, such as catalysis or binding, describing the actions of a gene product at the molecular level. A given gene product may exhibit one or more molecular functions." [GOC:go_curators]


id: GO:0003677
name: DNA binding
namespace: molecular_function
def:
  "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw]


id: GO:0003678
name: DNA helicase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA helix." [GOC:jl, GOC:mah]


id: GO:0003680
name: AT DNA binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with oligo(A) and oligo(T) tracts of DNA (AT DNA)." [GOC:jl, PMID:2670564]


id: GO:0003681
name: bent DNA binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with DNA in a bent conformation." [GOC:jl, PMID:12627977]


id: GO:0003682
name: chromatin binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:jl, ISBN:0198506732, PMID:20404130]


id: GO:0003688
name: DNA replication origin binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with the DNA replication origin, a unique DNA sequence of a replicon at which DNA replication is initiated and proceeds bidirectionally or unidirectionally." [GOC:curators]


id: GO:0003689
name: DNA clamp loader activity
namespace: molecular_function
def:
  "Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the opening of the ring structure of the PCNA complex, or any of the related sliding clamp complexes, and their closing around the DNA duplex." [GOC:mah, GOC:vw, PMID:16082778]


id: GO:0003691
name: double-stranded telomeric DNA binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with double-stranded telomere-associated DNA." [GOC:jl, ISBN:0321000382]


id: GO:0003692
name: left-handed Z-DNA binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with DNA in the Z form, i.e. a left-handed helix in which the phosphate backbone zigzags." [ISBN:0716720094]


id: GO:0003693
name: P-element binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with any P-element, a class of Drosophila transposon responsible for hybrid dysgenesis." [GOC:jl, PMID:9440262]


id: GO:0003694
name: obsolete plasmid binding
namespace: molecular_function
def:
  "OBSOLETE. Interacting selectively with a plasmid, an extrachromosomal genetic element usually characterized as a covalently continuous double stranded DNA molecule found in bacteria and some other microorganisms." [ISBN:0198506732]


id: GO:0003696
name: satellite DNA binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with satellite DNA, the many tandem repeats (identical or related) of a short basic repeating unit; many have a base composition or other property different from the genome average that allows them to be separated from the bulk (main band) genomic DNA." [GOC:jl, SO:0000005]


id: GO:0003697
name: single-stranded DNA binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with single-stranded DNA." [GOC:elh, GOC:vw, PMID:22976174]


id: GO:0003700
name: transcription factor activity, sequence-specific DNA binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators, GOC:txnOH]


id: GO:0003704
name: obsolete specific RNA polymerase II transcription factor activity
namespace: molecular_function
def:
  "OBSOLETE. Functions to enable the transcription of specific, or specific sets, of genes by RNA polymerase II." [GOC:ma]


id: GO:0003705
name: transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with a sequence of DNA that is in a distal enhancer region for RNA polymerase II (RNAP II) in order to modulate transcription by RNAP II." [GOC:jl, GOC:txnOH]


id: GO:0003706
name: obsolete ligand-regulated transcription factor activity
namespace: molecular_function
def:
  "OBSOLETE. Functions to enable the transcription of specific, or specific sets, of genes by RNA polymerase II in response to a ligand." [GOC:curators]


id: GO:0003707
name: steroid hormone receptor activity
namespace: molecular_function
def:
  "Combining with a steroid hormone and transmitting the signal within the cell to initiate a change in cell activity or function." [GOC:signaling, PMID:14708019]


id: GO:0003708
name: retinoic acid receptor activity
namespace: molecular_function
def:
  "Combining with retinoic acid and transmitting the signal to the transcriptional machinery by interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription by RNA polymerase II. Retinoic acid is one of the forms of vitamin A." [GOC:signaling, PMID:1328967]


id: GO:0003711
name: obsolete transcription elongation regulator activity
namespace: molecular_function
def:
  "OBSOLETE. Any activity that modulates the rate of transcription elongation, the addition of ribonucleotides to an RNA molecule following transcription initiation." [GOC:mah]


id: GO:0003712
name: transcription cofactor activity
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with a regulatory transcription factor and also with the basal transcription machinery in order to modulate transcription. Cofactors generally do not bind the template nucleic acid, but rather mediate protein-protein interactions between regulatory transcription factors and the basal transcription machinery." [GOC:txnOH, PMID:10213677, PMID:16858867]


id: GO:0003713
name: transcription coactivator activity
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with a activating transcription factor and also with the basal transcription machinery in order to increase the frequency, rate or extent of transcription. Cofactors generally do not bind the template nucleic acid, but rather mediate protein-protein interactions between activating transcription factors and the basal transcription machinery." [GOC:txnOH, PMID:10213677, PMID:16858867]


id: GO:0003714
name: transcription corepressor activity
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with a repressing transcription factor and also with the basal transcription machinery in order to stop, prevent, or reduce the frequency, rate or extent of transcription. Cofactors generally do not bind the template nucleic acid, but rather mediate protein-protein interactions between repressive transcription factors and the basal transcription machinery." [GOC:txnOH, PMID:10213677, PMID:16858867]


id: GO:0003716
name: obsolete RNA polymerase I transcription termination factor activity
namespace: molecular_function
def:
  "OBSOLETE. Any activity that brings about termination of transcription by RNA polymerase I." [GOC:mah]


id: GO:0003717
name: obsolete RNA polymerase II transcription termination factor activity
namespace: molecular_function
def:
  "OBSOLETE. Any activity that brings about termination of transcription by RNA polymerase II." [GOC:mah]


id: GO:0003718
name: obsolete RNA polymerase III transcription termination factor activity
namespace: molecular_function
def:
  "OBSOLETE. Any activity that brings about termination of transcription by RNA polymerase III." [GOC:mah]


id: GO:0003720
name: telomerase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes extension of the 3'- end of a DNA strand by one deoxynucleotide at a time using an internal RNA template that encodes the telomeric repeat sequence." [GOC:krc]


id: GO:0003721
name: telomerase RNA reverse transcriptase activity
namespace: molecular_function
def:
  "Catalysis of the extension of the 3' end of a DNA strand by one deoxynucleotide at a time. Cannot initiate a chain de novo; uses the RNA subunit of the telomerase enzyme complex as its template." [EC:2.7.7.49, PMID:11812242]


id: GO:0003724
name: RNA helicase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a RNA helix." [GOC:jl, GOC:mah]


id: GO:0003726
name: double-stranded RNA adenosine deaminase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: adenosine + H2O = inosine + NH3, in a double-stranded RNA molecule." [GOC:mah]


id: GO:0003729
name: mRNA binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns." [GOC:kmv, SO:0000234]


id: GO:0003730
name: mRNA 3'-UTR binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with the 3' untranslated region of an mRNA molecule." [GOC:mah]


id: GO:0003731
name: obsolete mRNA cap binding
namespace: molecular_function
def:
  "OBSOLETE. Interacting selectively with the 7-methylguanosine cap at the 5' end of a nascent messenger RNA transcript." [GOC:mah]


id: GO:0003732
name: obsolete snRNA cap binding
namespace: molecular_function
def:
  "OBSOLETE. Interacting selectively with the cap structure at the 5' end of a small nuclear RNA molecule." [GOC:mah]


id: GO:0003743
name: translation initiation factor activity
namespace: molecular_function
def:
  "Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide." [ISBN:0198506732]


id: GO:0003747
name: translation release factor activity
namespace: molecular_function
def:
  "Involved in catalyzing the release of a nascent polypeptide chain from a ribosome." [ISBN:0198547684]


id: GO:0003754
name: obsolete chaperone activity
namespace: molecular_function
def:
  "OBSOLETE. Assists in the correct non-covalent assembly of polypeptide-containing structures in vivo, but is not a component of these assembled structures when they are performing their normal biological function." [ISBN:0198547684]


id: GO:0003755
name: peptidyl-prolyl cis-trans isomerase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0)." [EC:5.2.1.8]


id: GO:0003756
name: protein disulfide isomerase activity
namespace: molecular_function
def:
  "Catalysis of the rearrangement of both intrachain and interchain disulfide bonds in proteins." [EC:5.3.4.1]


id: GO:0003759
name: obsolete glycoprotein-specific chaperone activity
namespace: molecular_function
def:
  "OBSOLETE. Assists in the correct, non-covalent assembly of glycoproteins in vivo, but is not a component of the assembled structures when performing its normal biological function. Utilizes a lectin site as a means to associate with the unfolded glycoproteins." [GOC:jl, PMID:11337494]


id: GO:0003762
name: obsolete histone-specific chaperone activity
namespace: molecular_function
def:
  "OBSOLETE. Assists in chromatin assembly by chaperoning histones on to replicating DNA, but is not a component of the assembled nucleosome when performing its normal biological function." [GOC:jl, PMID:7600578, PMID:9325046]


id: GO:0003763
name: obsolete chaperonin ATPase activity
namespace: molecular_function
def:
  "OBSOLETE. Catalysis of the reaction: ATP + H2O = ADP + phosphate. The hydrolysis of ATP involved in maintaining an unfolded polypeptide structure before folding or to entry into mitochondria and chloroplasts." [EC:3.6.4.9, ISBN:0198547684]


id: GO:0003767
name: obsolete co-chaperone activity
namespace: molecular_function
def:
  "OBSOLETE. Co-chaperones are proteins that bind to chaperones and this complex then folds misfolded proteins. Co-chaperones by themselves do not possess chaperone activity." [GOC:rb]


id: GO:0003772
name: obsolete co-chaperonin activity
namespace: molecular_function
def:
  "OBSOLETE. Co-chaperonins are proteins that bind to chaperones and this complex then folds misfolded proteins. Co-chaperonins by themselves do not possess chaperone activity." [GOC:rb]


id: GO:0003773
name: obsolete heat shock protein activity
namespace: molecular_function
def:
  "OBSOLETE. Any of a group of specific proteins that are synthesized by both prokaryotic and eukaryotic cells after they have been exposed to a temperature that is higher than normal. Other stresses, e.g. free radical damage, have a similar effect. Many members of the hsp family are not induced but are present in all cells. They are characterized by their role as molecular chaperones." [ISBN:0198547684]


id: GO:0003774
name: motor activity
namespace: molecular_function
def:
  "Catalysis of the generation of force resulting either in movement along a microfilament or microtubule, or in torque resulting in membrane scission, coupled to the hydrolysis of a nucleoside triphosphate." [GOC:mah, GOC:vw, ISBN:0815316194, PMID:11242086]


id: GO:0003777
name: microtubule motor activity
namespace: molecular_function
def:
  "Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP)." [GOC:mah, ISBN:0815316194]


id: GO:0003779
name: actin binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments." [GOC:clt]


id: GO:0003793
name: obsolete defense/immunity protein activity
namespace: molecular_function
def:
  "OBSOLETE. Any activity that plays a role in the defense/immune response of an organism against infection and disease." [GOC:go_curators]


id: GO:0003796
name: lysozyme activity
namespace: molecular_function
def:
  "Catalysis of the hydrolysis of the beta-(1->4) linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins." [EC:3.2.1.17]


id: GO:0003798
name: obsolete male-specific antibacterial peptide activity
namespace: molecular_function
def:
  "OBSOLETE. Inhibits the growth of, or directly kills, bacterial cells, but which is only expressed in males." [GOC:go_curators]


id: GO:0003802
name: obsolete coagulation factor VIIa activity
namespace: molecular_function
def:
  "OBSOLETE. Catalysis of the selective cleavage of one Arg-Ile bond in factor X to form factor Xa, and on factor IX to form factor IXa beta." [EC:3.4.21.21, PMID:12496253]


id: GO:0003803
name: obsolete coagulation factor IXa activity
namespace: molecular_function
def:
  "OBSOLETE. Catalysis of the selective cleavage of the Arg-Ile bond in factor X to form factor Xa." [EC:3.4.21.22]


id: GO:0003804
name: obsolete coagulation factor Xa activity
namespace: molecular_function
def:
  "OBSOLETE. Catalysis of the preferential cleavage of Arg-Thr and then Arg-Ile bonds in prothrombin to form thrombin, and on factor VII, which it converts to a two-chain form (factor VIIa)." [EC:3.4.21.6, GOC:jl, PMID:7354023]


id: GO:0003805
name: obsolete coagulation factor XIa activity
namespace: molecular_function
def:
  "OBSOLETE. Catalysis of the selective cleavage of Arg-Ala and Arg-Val bonds in factor IX to form factor IXa." [EC:3.4.21.27]


id: GO:0003806
name: obsolete coagulation factor XIIa activity
namespace: molecular_function
def:
  "OBSOLETE. Catalysis of the selective cleavage of Arg-Ile bonds in factor VII to form factor VIIa and factor XI to form factor XIa." [EC:3.4.21.38]


id: GO:0003807
name: obsolete plasma kallikrein activity
namespace: molecular_function
def:
  "OBSOLETE. Catalysis of the selective cleavage of Arg-Xaa and Lys-Xaa bonds, including Lys-Arg and Arg-Ser bonds in (human) kininogen to release bradykinin." [EC:3.4.21.34]


id: GO:0003809
name: obsolete thrombin activity
namespace: molecular_function
def:
  "OBSOLETE. Catalysis of the preferential cleavage of Arg-Gly; activates fibrinogen to fibrin and releases fibrinopeptide A and B." [EC:3.4.21.5]


id: GO:0003810
name: protein-glutamine gamma-glutamyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: protein glutamine + alkylamine = protein N5-alkylglutamine + NH3. This reaction is the formation of the N6-(L-isoglutamyl)-L-lysine isopeptide, resulting in cross-linking polypeptide chains; the gamma-carboxamide groups of peptidyl-glutamine residues act as acyl donors, and the 6-amino-groups of peptidyl-lysine residues act as acceptors, to give intra- and intermolecular N6-(5-glutamyl)lysine cross-links." [EC:2.3.2.13, RESID:AA0124]


id: GO:0003812
name: obsolete alternative-complement-pathway C3/C5 convertase activity
namespace: molecular_function
def:
  "OBSOLETE. Catalysis of the cleavage of Arg-Ser bond in complement component C3 alpha-chain to yield C3a and C3b, and Arg bond in complement component C5 alpha-chain to yield C5a and C5b." [EC:3.4.21.47]


id: GO:0003813
name: obsolete classical-complement-pathway C3/C5 convertase activity
namespace: molecular_function
def:
  "OBSOLETE. Catalysis of the selective cleavage of Arg-Ser bond in complement component C3 alpha-chain to form C3a and C3b, and Arg bond in complement component C5 alpha-chain to form C5a and C5b." [EC:3.4.21.43]


id: GO:0003815
name: obsolete complement component C1r activity
namespace: molecular_function
def:
  "OBSOLETE. Catalysis of the selective cleavage of Lys(or Arg)-Ile bond in complement subcomponent C1s to form the active form of C1s (EC:3.4.21.42)." [EC:3.4.21.41]


id: GO:0003816
name: obsolete complement component C1s activity
namespace: molecular_function
def:
  "OBSOLETE. Catalysis of the cleavage of component C4 to C4a and C4b (Arg-Ala bond), and component C2 to C2a and C2b (Lys-Lys or Arg-Lys bond)." [EC:3.4.21.42]


id: GO:0003817
name: obsolete complement factor D activity
namespace: molecular_function
def:
  "OBSOLETE. Catalysis of the cleavage of component factor B (Arg-Lys) when in complex with C3b or with cobra venom factor (CVF)." [EC:3.4.21.46]


id: GO:0003818
name: obsolete complement factor I activity
namespace: molecular_function
def:
  "OBSOLETE. Catalysis of the inactivation of complement subcomponents C3b, iC3b and C4b by proteolytic cleavage." [EC:3.4.21.45]


id: GO:0003823
name: antigen binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with an antigen, any substance which is capable of inducing a specific immune response and of reacting with the products of that response, the specific antibody or specifically sensitized T-lymphocytes, or both. Binding may counteract the biological activity of the antigen." [GOC:jl, ISBN:0198506732, ISBN:0721662544]


id: GO:0003824
name: catalytic activity
namespace: molecular_function
def:
  "Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732]


id: GO:0003825
name: alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity
namespace: molecular_function
def:
  "Catalysis of the reaction: UDP-glucose + D-glucose-6-phosphate = UDP + alpha,alpha-trehalose-6-phosphate." [EC:2.4.1.15]


id: GO:0003827
name: alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 3-(alpha-D-mannosyl)-beta-D-mannosyl-R + UDP-N-acetyl-alpha-D-glucosamine = 3-(2-[N-acetyl-beta-D-glucosaminyl]-alpha-D-mannosyl)-beta-D-mannosyl-R + H(+) + UDP." [EC:2.4.1.101, RHEA:11459]


id: GO:0003828
name: alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: CMP-N-acetylneuraminate + alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-R = CMP + alpha-N-acetylneuraminyl-(2->8)-alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-R." [EC:2.4.99.8]


id: GO:0003829
name: beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-(1->3)-N-acetyl-D-galactosaminyl-R = UDP + beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-D-galactosaminyl-R." [EC:2.4.1.102]


id: GO:0003830
name: beta-1,4-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + beta-D-mannosyl-R = UDP + 4-(N-acetyl-beta-D-glucosaminyl)-beta-D-mannosyl-R." [EC:2.4.1.144]


id: GO:0003831
name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: UDP-galactose + N-acetyl-beta-D-glucosaminylglycopeptide = UDP + beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminylglycopeptide." [EC:2.4.1.38]


id: GO:0003832
name: beta-alanyl-dopamine hydrolase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: N-beta-alanyl dopamine + H2O = dopamine + beta-alanine." [GOC:bf, ISBN:0198506732, PMID:12957543]


id: GO:0003833
name: beta-alanyl-dopamine synthase activity
namespace: molecular_function
def:
  "Catalysis of the synthesis of beta-alanyl-dopamine from the precursor dopamine (3,4-dihydroxyphenylethylamine)." [GOC:bf, ISBN:0198506732, PMID:12957543]


id: GO:0003835
name: beta-galactoside alpha-2,6-sialyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: CMP-N-acetylneuraminate + beta-D-galactosyl-(1->4)-acetyl-beta-D-glucosamine = CMP + alpha-N-acetylneuraminyl-(2->6)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosamine." [EC:2.4.99.1]


id: GO:0003836
name: beta-galactoside (CMP) alpha-2,3-sialyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: CMP-N-acetylneuraminate + beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl-R = CMP + alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl-R." [EC:2.4.99.4]


id: GO:0003837
name: beta-ureidopropionase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: N-carbamoyl-beta-alanine + H2O = beta-alanine + CO2 + NH3." [EC:3.5.1.6]


id: GO:0003838
name: sterol 24-C-methyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: S-adenosyl-L-methionine + 5-alpha-cholest-8,24-dien-3-beta-ol = S-adenosyl-L-homocysteine + 24-methylene-5-alpha-cholest-8-en-3-beta-ol." [EC:2.1.1.41]


id: GO:0003839
name: gamma-glutamylcyclotransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: (5-L-glutamyl)-L-amino acid = 5-oxoproline + L-amino acid." [EC:2.3.2.4]


id: GO:0003840
name: gamma-glutamyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: (5-L-glutamyl)-peptide + an amino acid = peptide + 5-L-glutamyl-amino acid." [EC:2.3.2.2]


id: GO:0003841
name: 1-acylglycerol-3-phosphate O-acyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: acyl-CoA + 1-acyl-sn-glycerol-3-phosphate = CoA + 1,2-diacyl-sn-glycerol-3-phosphate." [EC:2.3.1.51, GOC:ab]


id: GO:0003842
name: 1-pyrroline-5-carboxylate dehydrogenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 1-pyrroline-5-carboxylate + NAD+ + H2O = L-glutamate + NADH + H(+)." [EC:1.5.1.12]


id: GO:0003843
name: 1,3-beta-D-glucan synthase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: UDP-glucose + [(1->3)-beta-D-glucosyl](n) = UDP + [(1->3)-beta-D-glucosyl](n+1)." [EC:2.4.1.34]


id: GO:0003844
name: 1,4-alpha-glucan branching enzyme activity
namespace: molecular_function
def:
  "Catalysis of the transfer of a segment of a (1->4)-alpha-D-glucan chain to a primary hydroxyl group in a similar glucan chain." [EC:2.4.1.18]


id: GO:0003845
name: 11-beta-hydroxysteroid dehydrogenase [NAD(P)] activity
namespace: molecular_function
def:
  "Catalysis of the reaction: an 11-beta-hydroxysteroid + NAD(P)+ = an 11-oxosteroid + NAD(P)H + H(+)." [EC:1.1.1.146, PMID:15761036]


id: GO:0003847
name: 1-alkyl-2-acetylglycerophosphocholine esterase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 2-acetyl-1-alkyl-sn-glycero-3-phosphocholine + H2O = 1-alkyl-sn-glycero-3-phosphocholine + acetate." [EC:3.1.1.47]


id: GO:0003848
name: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine + ATP = (2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl diphosphate + AMP + 2 H(+)." [EC:2.7.6.3, RHEA:11415]


id: GO:0003849
name: 3-deoxy-7-phosphoheptulonate synthase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: D-erythrose 4-phosphate + H(2)O + phosphoenolpyruvate = 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate." [EC:2.5.1.54, RHEA:14720]


id: GO:0003850
name: 2-deoxyglucose-6-phosphatase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 2-deoxy-D-glucose-6-phosphate + H2O = 2-deoxy-D-glucose + phosphate." [EC:3.1.3.68]


id: GO:0003851
name: 2-hydroxyacylsphingosine 1-beta-galactosyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: UDP-galactose + 2-(2-hydroxyacyl)sphingosine = UDP + 1-(beta-D-galactosyl)-2-(2-hydroxyacyl)sphingosine." [EC:2.4.1.45]


id: GO:0003852
name: 2-isopropylmalate synthase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 3-methyl-2-oxobutanoate + acetyl-CoA + H(2)O = (2S)-2-isopropylmalate + CoA + H(+)." [EC:2.3.3.13, RHEA:21527]


id: GO:0003853
name: 2-methylacyl-CoA dehydrogenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 2-methylbutanoyl-CoA + acceptor = 2-methylbut-2-enoyl-CoA + reduced acceptor." [EC:1.3.99.12]


id: GO:0003854
name: 3-beta-hydroxy-delta5-steroid dehydrogenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: a 3-beta-hydroxy-delta(5)-steroid + NAD+ = a 3-oxo-delta(5)-steroid + NADH + H(+)." [EC:1.1.1.145]


id: GO:0003855
name: 3-dehydroquinate dehydratase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 3-dehydroquinate = 3-dehydroshikimate + H(2)O." [EC:4.2.1.10, RHEA:21099]


id: GO:0003856
name: 3-dehydroquinate synthase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate = 3-dehydroquinate + phosphate." [EC:4.2.3.4, RHEA:21971]


id: GO:0003857
name: 3-hydroxyacyl-CoA dehydrogenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: (S)-3-hydroxyacyl-CoA + NAD+ = 3-oxoacyl-CoA + NADH + H(+)." [EC:1.1.1.35]


id: GO:0003858
name: 3-hydroxybutyrate dehydrogenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: (R)-3-hydroxybutanoate + NAD(+) = acetoacetate + H(+) + NADH." [EC:1.1.1.30, RHEA:20524]


id: GO:0003859
name: 3-hydroxybutyryl-CoA dehydratase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: (R)-3-hydroxybutanoyl-CoA = crotonoyl-CoA + H(2)O." [EC:4.2.1.55, RHEA:17852]


id: GO:0003860
name: 3-hydroxyisobutyryl-CoA hydrolase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 3-hydroxy-2-methylpropanoyl-CoA + H2O = CoA + 3-hydroxy-2-methylpropanoate." [EC:3.1.2.4]


id: GO:0003862
name: 3-isopropylmalate dehydrogenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 3-carboxy-2-hydroxy-4-methylpentanoate + NAD+ = 3-carboxy-4-methyl-2-oxopentanoate + NADH + H+." [EC:1.1.1.85]


id: GO:0003863
name: 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 3-methyl-2-oxobutanoate + lipoamide = S-(2-methylpropanoyl)dihydrolipoamide + CO2." [EC:1.2.4.4]


id: GO:0003864
name: 3-methyl-2-oxobutanoate hydroxymethyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 5,10-methylenetetrahydrofolate + 3-methyl-2-oxobutanoate = tetrahydrofolate + 2-dehydropantoate." [EC:2.1.2.11]


id: GO:0003865
name: 3-oxo-5-alpha-steroid 4-dehydrogenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: a 3-oxo-5-alpha-steroid + acceptor = a 3-oxo-delta(4)-steroid + reduced acceptor." [EC:1.3.99.5]


id: GO:0003866
name: 3-phosphoshikimate 1-carboxyvinyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 3-phosphoshikimate + phosphoenolpyruvate = 5-O-(1-carboxyvinyl)-3-phosphoshikimate + phosphate." [EC:2.5.1.19, RHEA:21259]


id: GO:0003867
name: 4-aminobutyrate transaminase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 4-aminobutanoate + amino group acceptor = succinate semialdehyde + amino acid." [EC:2.6.1.19, GOC:mah]


id: GO:0003870
name: 5-aminolevulinate synthase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: glycine + H(+) + succinyl-CoA = 5-aminolevulinate + CO(2) + CoA." [EC:2.3.1.37, RHEA:12924]


id: GO:0003871
name: 5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 5-methyltetrahydropteroyltri-L-glutamate + L-homocysteine = L-methionine + tetrahydropteroyltri-L-glutamate." [EC:2.1.1.14, RHEA:21199]


id: GO:0003872
name: 6-phosphofructokinase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: ATP + D-fructose-6-phosphate = ADP + D-fructose 1,6-bisphosphate." [EC:2.7.1.11]


id: GO:0003873
name: 6-phosphofructo-2-kinase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: beta-D-fructose 6-phosphate + ATP = beta-D-fructose 2,6-bisphosphate + ADP + 2 H(+)." [EC:2.7.1.105, RHEA:15656]


id: GO:0003874
name: 6-pyruvoyltetrahydropterin synthase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 7,8-dihydroneopterin 3'-triphosphate = 6-pyruvoyl-5,6,7,8-tetrahydropterin + H(+) + triphosphate." [EC:4.2.3.12, RHEA:22051]


id: GO:0003875
name: ADP-ribosylarginine hydrolase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: N2-(ADP-D-ribosyl)-L-arginine + H2O = L-arginine + ADP-ribose." [EC:3.2.2.19]


id: GO:0003877
name: ATP adenylyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: ADP + ATP = phosphate + P(1),P(4)-bis(5'-adenosyl)tetraphosphate." [EC:2.7.7.53]


id: GO:0003878
name: ATP citrate synthase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: acetyl-CoA + ADP + H(+) + oxaloacetate + phosphate = ATP + citrate + CoA." [EC:2.3.3.8, RHEA:21163]


id: GO:0003879
name: ATP phosphoribosyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 1-(5-phospho-D-ribosyl)-ATP + diphosphate = ATP + 5-phospho-alpha-D-ribose 1-diphosphate." [EC:2.4.2.17]


id: GO:0003880
name: protein C-terminal carboxyl O-methyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the transfer of a methyl group to the oxygen atom of a carboxyl group at the C-terminal of a protein." [PMID:8428937]


id: GO:0003881
name: CDP-diacylglycerol-inositol 3-phosphatidyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: myo-inositol + CDP-diacylglycerol = 1-phosphatidyl-1D-myo-inositol + CMP + H(+)." [EC:2.7.8.11, RHEA:11583]


id: GO:0003882
name: CDP-diacylglycerol-serine O-phosphatidyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: CDP-diacylglycerol + L-serine = CMP + O-sn-phosphatidyl-L-serine." [EC:2.7.8.8]


id: GO:0003884
name: D-amino-acid oxidase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: a D-amino acid + H2O + O2 = a 2-oxo acid + NH3 + hydrogen peroxide." [EC:1.4.3.3]


id: GO:0003885
name: D-arabinono-1,4-lactone oxidase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: D-arabinono-1,4-lactone + O(2) = dehydro-D-arabinono-1,4-lactone + H(2)O(2) + H(+)." [EC:1.1.3.37, RHEA:23759]


id: GO:0003886
name: DNA (cytosine-5-)-methyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: S-adenosyl-L-methionine + DNA containing cytosine = S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine." [EC:2.1.1.37]


id: GO:0003887
name: DNA-directed DNA polymerase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a DNA template and a 3'hydroxyl group." [EC:2.7.7.7, GOC:vw, ISBN:0198547684]


id: GO:0003892
name: obsolete proliferating cell nuclear antigen
namespace: molecular_function
def:
  "OBSOLETE. A nuclear protein that associates as a trimer and then interacts with delta DNA polymerase and epsilon DNA polymerase, acting as an auxiliary factor for DNA replication and DNA repair." [ISBN:0123668387]


id: GO:0003896
name: DNA primase activity
namespace: molecular_function
def:
  "Catalysis of the synthesis of a short RNA primer on a DNA template, providing a free 3'-OH that can be extended by DNA-directed DNA polymerases." [GOC:mah, GOC:mcc, ISBN:0716720094, PMID:26184436]


id: GO:0003899
name: DNA-directed RNA polymerase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'." [EC:2.7.7.6]


id: GO:0003900
name: obsolete DNA-directed RNA polymerase I activity
namespace: molecular_function
def:
  "OBSOLETE. Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1)." [EC:2.7.7.6]


id: GO:0003904
name: deoxyribodipyrimidine photo-lyase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: cyclobutadipyrimidine (in DNA) = 2 pyrimidine residues (in DNA). This reaction represents the reactivation of irradiated DNA by light." [EC:4.1.99.3]


id: GO:0003905
name: alkylbase DNA N-glycosylase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: DNA with alkylated base + H2O = DNA with abasic site + alkylated base. This reaction is the hydrolysis of DNA by cleavage of the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar to remove an alkylated base, leaving an apyrimidinic or apurinic site." [EC:3.2.2.21, GOC:elh, PMID:10872450, PMID:9224623]


id: GO:0003906
name: DNA-(apurinic or apyrimidinic site) lyase activity
namespace: molecular_function
def:
  "Catalysis of the cleavage of the C-O-P bond 3' to the apurinic or apyrimidinic site in DNA by a beta-elimination reaction, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate." [EC:4.2.99.18]


id: GO:0003908
name: methylated-DNA-[protein]-cysteine S-methyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: DNA (containing 6-O-methylguanine) + (protein)-L-cysteine = DNA (without 6-O-methylguanine) + protein S-methyl-L-cysteine." [EC:2.1.1.63]


id: GO:0003909
name: DNA ligase activity
namespace: molecular_function
def:
  "Catalysis of the formation of a phosphodiester bond between the 3'-hydroxyl group at the end of one DNA chain and the 5'-phosphate group at the end of another. This reaction requires an energy source such as ATP or NAD+." [ISBN:0716720094]


id: GO:0003910
name: DNA ligase (ATP) activity
namespace: molecular_function
def:
  "Catalysis of the reaction: ATP + deoxyribonucleotide(n) + deoxyribonucleotide(m) = AMP + diphosphate + deoxyribonucleotide(n+m)." [EC:6.5.1.1]


id: GO:0003911
name: DNA ligase (NAD+) activity
namespace: molecular_function
def:
  "Catalysis of the reaction: NAD+ + deoxyribonucleotide(n) + deoxyribonucleotide(m) = AMP + nicotinamide nucleotide + deoxyribonucleotide(n+m)." [EC:6.5.1.2]


id: GO:0003912
name: DNA nucleotidylexotransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1)." [EC:2.7.7.31]


id: GO:0003913
name: DNA photolyase activity
namespace: molecular_function
def:
  "Catalysis of the repair of a photoproduct resulting from ultraviolet irradiation of two adjacent pyrimidine residues in DNA." [GOC:mah, PMID:11124949]


id: GO:0003914
name: DNA (6-4) photolyase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: pyrimidine-pyrimidone (6-4) photoproduct (in DNA) = 2 pyrimidine residues (in DNA). Catalyzes the reactivation of ultraviolet-irradiated DNA." [GOC:mah, PMID:11124949]


id: GO:0003916
name: DNA topoisomerase activity
namespace: molecular_function
def:
  "Catalysis of the transient cleavage and passage of individual DNA strands or double helices through one another, resulting a topological transformation in double-stranded DNA." [GOC:mah, PMID:8811192]


id: GO:0003917
name: DNA topoisomerase type I activity
namespace: molecular_function
def:
  "Catalysis of a DNA topological transformation by transiently cleaving one DNA strand at a time to allow passage of another strand; changes the linking number by +1 per catalytic cycle." [PMID:8811192]


id: GO:0003918
name: DNA topoisomerase type II (ATP-hydrolyzing) activity
namespace: molecular_function
def:
  "Catalysis of a DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined; product release is coupled to ATP binding and hydrolysis; changes the linking number in multiples of 2." [PMID:8811192]


id: GO:0003920
name: GMP reductase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: IMP + NADP(+) + NH(4)(+) = GMP + 2 H(+) + NADPH." [EC:1.7.1.7, RHEA:17188]


id: GO:0003921
name: GMP synthase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: ATP + xanthosine 5'-phosphate + NH3 = AMP + diphosphate + GMP." [EC:6.3.4.1]


id: GO:0003922
name: GMP synthase (glutamine-hydrolyzing) activity
namespace: molecular_function
def:
  "Catalysis of the reaction: ATP + xanthosine 5'-phosphate + L-glutamine + H2O = AMP + diphosphate + GMP + L-glutamate." [EC:6.3.5.2]


id: GO:0003923
name: GPI-anchor transamidase activity
namespace: molecular_function
def:
  "Catalysis of the formation of the linkage between a protein and a glycosylphosphatidylinositol anchor. The reaction probably occurs by subjecting a peptide bond to nucleophilic attack by the amino group of ethanolamine-GPI, transferring the protein from a signal peptide to the GPI anchor." [ISBN:0471331309]


id: GO:0003925
name: obsolete small monomeric GTPase activity
namespace: molecular_function
def:
  "OBSOLETE. Catalysis of the reaction: GTP + H2O = GDP + phosphate. Small monomeric enzymes with a molecular mass of 21 kDa that are distantly related to the alpha-subunit of heterotrimeric G-protein GTPase. They are involved in cell-growth regulation (RAS subfamily), membrane vesicle traffic and uncoating (RAB and ARF subfamilies), nuclear protein import (RAN subfamily) and organization of the cytoskeleton (Rho and Rac subfamilies)." [EC:3.6.5.2, GOC:mah, ISBN:0198547684, MetaCyc:3.6.1.47-RXN]


id: GO:0003927
name: obsolete heterotrimeric G-protein GTPase activity
namespace: molecular_function
def:
  "OBSOLETE. Catalysis of the reaction: GTP + H2O = GDP + phosphate. GTP-hydrolyzing enzymes, where GTP and GDP alternate in binding. Includes stimulatory and inhibitory G-proteins such as Gs, Gi, Go and Golf, targeting adenylate cyclase and/or potassium ion and calcium ion channels; Gq stimulating phospholipase C; transducin activating cGMP phosphodiesterase; gustducin activating cAMP phosphodiesterase." [EC:3.6.5.1, ISBN:0198547684, MetaCyc:3.6.1.46-RXN]


id: GO:0003931
name: obsolete Rho small monomeric GTPase activity
namespace: molecular_function
def:
  "OBSOLETE. Catalysis of the reaction: GTP + H2O = GDP + phosphate. Any member of the Rho subfamily of the RAS superfamily of monomeric GTPases. Proteins in the Rho subfamily are involved in relaying signals from cell-surface receptors to the actin cytoskeleton." [EC:3.6.1.47, GOC:mah, ISBN:0198547684]


id: GO:0003933
name: GTP cyclohydrolase activity
namespace: molecular_function
def:
  "Catalysis of the hydrolysis of the imidazole ring of GTP, releasing formate. Two C-N bonds are hydrolyzed and the pentase unit is isomerized." [EC:3.5.4.16, EC:3.5.4.25, EC:3.5.4.29, GOC:curators]


id: GO:0003934
name: GTP cyclohydrolase I activity
namespace: molecular_function
def:
  "Catalysis of the reaction: GTP + H2O = formate + 7,8-dihydroneopterin 3'-triphosphate." [EC:3.5.4.16]


id: GO:0003935
name: GTP cyclohydrolase II activity
namespace: molecular_function
def:
  "Catalysis of the reaction: GTP + 3 H(2)O = 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + diphosphate + formate + 3 H(+)." [EC:3.5.4.25, RHEA:23707]


id: GO:0003936
name: obsolete hydrogen-transporting two-sector ATPase activity
namespace: molecular_function
def:
  "OBSOLETE. Catalysis of the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out)." [EC:3.6.3.14, TC:3.A.3.-.-]


id: GO:0003937
name: IMP cyclohydrolase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: IMP + H2O = 5-formamido-1-(5-phosphoribosyl)imidazole-4-carboxamide." [EC:3.5.4.10]


id: GO:0003938
name: IMP dehydrogenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: inosine 5'-phosphate + NAD+ + H2O = xanthosine 5'-phosphate + NADH + H+." [EC:1.1.1.205]


id: GO:0003942
name: N-acetyl-gamma-glutamyl-phosphate reductase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: N-acetyl-L-glutamate 5-semialdehyde + NADP+ + phosphate = N-acetyl-5-glutamyl phosphate + NADPH + H+." [EC:1.2.1.38]


id: GO:0003943
name: N-acetylgalactosamine-4-sulfatase activity
namespace: molecular_function
def:
  "Catalysis of the hydrolysis of the 4-sulfate groups of the N-acetyl-D-galactosamine 4-sulfate units of chondroitin sulfate and dermatan sulfate." [EC:3.1.6.12]


id: GO:0003944
name: N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: glycoprotein N-acetyl-D-glucosaminyl-phospho-D-mannose + H2O = N-acetyl-D-glucosamine + glycoprotein phospho-D-mannose." [EC:3.1.4.45]


id: GO:0003945
name: N-acetyllactosamine synthase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: UDP-galactose + N-acetyl-D-glucosamine = UDP + N-acetyllactosamine." [EC:2.4.1.90]


id: GO:0003947
name: (N-acetylneuraminyl)-galactosylglucosylceramide N-acetylgalactosaminyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: UDP-N-acetyl-D-galactosamine + (N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide = UDP + N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide." [EC:2.4.1.92]


id: GO:0003948
name: N4-(beta-N-acetylglucosaminyl)-L-asparaginase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: N(4)-(beta-N-acetyl-D-glucosaminyl)-L-asparagine + H(2)O = N-acetyl-beta-D-glucosaminylamine + L-aspartate + H(+)." [EC:3.5.1.26, RHEA:11547]


id: GO:0003949
namespace: molecular_function
name:
  1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase activity

def:
  "Catalysis of the reaction: 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide = 5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide." [EC:5.3.1.16, RHEA:15472]


id: GO:0003950
name: NAD+ ADP-ribosyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: NAD+ + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor." [EC:2.4.2.30]


id: GO:0003952
name: NAD+ synthase (glutamine-hydrolyzing) activity
namespace: molecular_function
def:
  "Catalysis of the reaction: ATP + deamido-NAD+ + L-glutamine + H2O = AMP + diphosphate + NAD+ + L-glutamate." [EC:6.3.5.1]


id: GO:0003956
name: NAD(P)+-protein-arginine ADP-ribosyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: NAD(P)+ + L-arginine = nicotinamide + N2-(ADP-D-ribosyl)-L-arginine." [EC:2.4.2.31]


id: GO:0003957
name: NAD(P)+ transhydrogenase (B-specific) activity
namespace: molecular_function
def:
  "Catalysis of the reaction: NADPH + H+ + NAD+ = NADP+ + NADH + H+, driving the transfer of a solute or solutes from one side of a membrane to the other. In the course of the reaction (left to right) one H atom is transferred from inside the cell to outside. The reaction is B-specific (i.e. the pro-S hydrogen is transferred from the 4-position of reduced nicotinamide cofactor) with respect to both NAD+ and NADP+." [EC:1.6.1.1, http://pubs.acs.org/cgi-bin/abstract.cgi/jacsat/1991/113/i07/f-pdf/f_ja00007a002.pdf, MetaCyc:PYRNUTRANSHYDROGEN-RXN]


id: GO:0003958
name: NADPH-hemoprotein reductase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: NADPH + H+ + n oxidized hemoprotein = NADP+ + n reduced hemoprotein." [EC:1.6.2.4]


id: GO:0003961
name: O-acetylhomoserine aminocarboxypropyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: O-acetyl-L-homoserine + methanethiol = L-methionine + acetate. Also reacts with other thiols and H2S, producing homocysteine or thioethers." [EC:2.5.1.49]


id: GO:0003962
name: cystathionine gamma-synthase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: O-succinyl-L-homoserine + L-cysteine = cystathionine + succinate." [EC:2.5.1.48]


id: GO:0003963
name: RNA-3'-phosphate cyclase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: ATP + RNA 3'-terminal-phosphate = AMP + diphosphate + RNA terminal-2',3'-cyclic-phosphate." [EC:6.5.1.4]


id: GO:0003964
name: RNA-directed DNA polymerase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49]


id: GO:0003966
name: obsolete RNA-directed DNA polymerase, transposon encoded
namespace: molecular_function
def:
  "OBSOLETE. Catalysis of RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time; cannot initiate a chain de novo." [EC:2.7.7.49]


id: GO:0003968
name: RNA-directed RNA polymerase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1); uses an RNA template." [EC:2.7.7.48, GOC:mah]


id: GO:0003972
name: RNA ligase (ATP) activity
namespace: molecular_function
def:
  "Catalysis of the reaction: ATP + ribonucleotide(n) + ribonucleotide(m) = AMP + diphosphate + ribonucleotide(n+m)." [EC:6.5.1.3]


id: GO:0003973
name: (S)-2-hydroxy-acid oxidase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: (S)-2-hydroxy-acid + O2 = 2-oxo acid + hydrogen peroxide." [EC:1.1.3.15]


id: GO:0003974
name: UDP-N-acetylglucosamine 4-epimerase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine = UDP-N-acetyl-D-galactosamine." [EC:5.1.3.7]


id: GO:0003975
name: UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + dolichyl phosphate = UMP + N-acetyl-D-glucosaminyl-diphosphodolichol." [EC:2.7.8.15]


id: GO:0003976
name: UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + lysosomal-enzyme D-mannose = UMP + lysosomal-enzyme N-acetyl-D-glucosaminyl-phospho-D-mannose." [EC:2.7.8.17]


id: GO:0003977
name: UDP-N-acetylglucosamine diphosphorylase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: N-acetyl-alpha-D-glucosamine 1-phosphate + UTP = diphosphate + UDP-N-acetyl-alpha-D-glucosamine." [EC:2.7.7.23, RHEA:13512]


id: GO:0003979
name: UDP-glucose 6-dehydrogenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: H(2)O + 2 NAD(+) + UDP-alpha-D-glucose = 3 H(+) + 2 NADH + UDP-alpha-D-glucuronate." [EC:1.1.1.22, RHEA:23599]


id: GO:0003980
name: UDP-glucose:glycoprotein glucosyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the addition of UDP-glucose on to asparagine-linked (N-linked) oligosaccharides of the form Man7-9GlcNAc2 on incorrectly folded glycoproteins." [GOC:al, PMID:10764828]


id: GO:0003983
name: UTP:glucose-1-phosphate uridylyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: alpha-D-glucose 1-phosphate + UTP = diphosphate + UDP-D-glucose." [EC:2.7.7.9, RHEA:19892]


id: GO:0003991
name: acetylglutamate kinase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: ATP + N-acetyl-L-glutamate = ADP + N-acetyl-L-glutamate-5-phosphate." [EC:2.7.2.8]


id: GO:0003992
name: N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 2-oxoglutarate + N(2)-acetyl-L-ornithine = N-acetyl-L-glutamate 5-semialdehyde + L-glutamate." [EC:2.6.1.11, RHEA:18052]


id: GO:0003993
name: acid phosphatase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an acid pH optimum." [EC:3.1.3.2]


id: GO:0003994
name: aconitate hydratase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: citrate = isocitrate. The reaction occurs in two steps: (1) citrate = cis-aconitate + H2O, (2) cis-aconitate + H2O = isocitrate. This reaction is the interconversion of citrate and isocitrate via the labile, enzyme-bound intermediate cis-aconitate. Water is removed from one part of the citrate molecule and added back to a different atom to form isocitrate." [EC:4.2.1.3, GOC:pde, GOC:vw]


id: GO:0003995
name: acyl-CoA dehydrogenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor." [EC:1.3.99.3]


id: GO:0003996
name: acyl-CoA ligase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: ATP + a long-chain carboxylic acid + CoA = AMP + diphosphate + an acyl-CoA; long-chain fatty acids have chain lengths of C13 to C22." [CHEBI:15904, EC:6.2.1.3, GOC:mah]


id: GO:0003997
name: acyl-CoA oxidase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: acyl-CoA + O2 = trans-2,3-dehydroacyl-CoA + hydrogen peroxide." [EC:1.3.3.6]


id: GO:0003999
name: adenine phosphoribosyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: AMP + diphosphate = adenine + 5-phospho-alpha-D-ribose 1-diphosphate." [EC:2.4.2.7]


id: GO:0004003
name: ATP-dependent DNA helicase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction drives the unwinding of the DNA helix." [EC:3.6.1.3, GOC:jl]


id: GO:0004004
name: ATP-dependent RNA helicase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction drives the unwinding of an RNA helix." [EC:3.6.1.3, GOC:jl]


id: GO:0004007
name: obsolete heavy metal-exporting ATPase activity
namespace: molecular_function
def:
  "OBSOLETE. Catalysis of the reaction: heavy metal ion(in) + ATP + H2O = heavy metal ion(out) + ADP + phosphate." [GOC:ai]


id: GO:0004008
name: copper-exporting ATPase activity
namespace: molecular_function
def:
  "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Cu2+(in) -> ADP + phosphate + Cu2+(out)." [EC:3.6.3.4]


id: GO:0004012
name: phospholipid-translocating ATPase activity
namespace: molecular_function
def:
  "Catalysis of the movement of phospholipids from one membrane bilayer leaflet to the other, driven by the hydrolysis of ATP." [EC:3.6.3.1, PMID:15919184, PMID:9099684]


id: GO:0004013
name: adenosylhomocysteinase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: S-adenosyl-L-homocysteine + H2O = adenosine + L-homocysteine." [EC:3.3.1.1]


id: GO:0004014
name: adenosylmethionine decarboxylase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: S-adenosyl-L-methionine + H(+) = S-adenosylmethioninamine + CO(2)." [EC:4.1.1.50, RHEA:15984]


id: GO:0004015
name: adenosylmethionine-8-amino-7-oxononanoate transaminase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 8-amino-7-oxononanoate + S-adenosyl-L-methionine(1+) = 7,8-diaminononanoate + S-adenosyl-4-methylthio-2-oxobutanoate." [EC:2.6.1.62, RHEA:16864]


id: GO:0004019
name: adenylosuccinate synthase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: L-aspartate + GTP + IMP = N(6)-(1,2-dicarboxyethyl)-AMP + GDP + 3 H(+) + phosphate." [EC:6.3.4.4, RHEA:15756]


id: GO:0004020
name: adenylylsulfate kinase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: ATP + adenylylsulfate = ADP + 3'-phosphoadenosine 5'-phosphosulfate." [EC:2.7.1.25]


id: GO:0004021
name: L-alanine:2-oxoglutarate aminotransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 2-oxoglutarate + L-alanine = L-glutamate + pyruvate." [EC:2.6.1.2, RHEA:19456]


id: GO:0004023
name: alcohol dehydrogenase activity, metal ion-independent
namespace: molecular_function
def:
  "Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+; can proceed in the absence of a metal ion." [EC:1.1.1.1, GOC:mah]


id: GO:0004024
name: alcohol dehydrogenase activity, zinc-dependent
namespace: molecular_function
def:
  "Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+, requiring the presence of zinc." [EC:1.1.1.1, GOC:mah]


id: GO:0004025
name: alcohol dehydrogenase activity, iron-dependent
namespace: molecular_function
def:
  "Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+, requiring the presence of iron." [EC:1.1.1.1, GOC:mah]


id: GO:0004027
name: alcohol sulfotransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + an alcohol = adenosine 3',5'-bisphosphate + an alkyl sulfate." [EC:2.8.2.2]


id: GO:0004028
name: 3-chloroallyl aldehyde dehydrogenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 3-chloroallyl aldehyde + H2O = 2 H+ + 2 e- + 3-chloroacrylic acid." [UM-BBD_enzymeID:e0432]


id: GO:0004031
name: aldehyde oxidase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: an aldehyde + H2O + O2 = a carboxylic acid + hydrogen peroxide." [EC:1.2.3.1]


id: GO:0004034
name: aldose 1-epimerase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: alpha-D-glucose = beta-D-glucose. Also acts on L-arabinose, D-xylose, D-galactose, maltose and lactose." [EC:5.1.3.3]


id: GO:0004035
name: alkaline phosphatase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an alkaline pH optimum." [EC:3.1.3.1]


id: GO:0004037
name: allantoicase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: allantoate + H(2)O = (S)-ureidoglycolate + urea." [EC:3.5.3.4, RHEA:11019]


id: GO:0004039
name: allophanate hydrolase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: H(2)O + 3 H(+) + urea-1-carboxylate = 2 CO(2) + 2 NH(4)(+)." [EC:3.5.1.54, RHEA:19032]


id: GO:0004040
name: amidase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: a monocarboxylic acid amide + H2O = a monocarboxylate + NH3." [EC:3.5.1.4]


id: GO:0004042
name: acetyl-CoA:L-glutamate N-acetyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: L-glutamate + acetyl-CoA = N-acetyl-L-glutamate + CoA + H(+)." [EC:2.3.1.1, RHEA:24295]


id: GO:0004043
name: L-aminoadipate-semialdehyde dehydrogenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: L-2-aminoadipate 6-semialdehyde + NADP+ + H2O = L-2-aminoadipate + NADPH + H+." [EC:1.2.1.31]


id: GO:0004044
name: amidophosphoribosyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 5-phospho-beta-D-ribosylamine + L-glutamate + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + L-glutamine + H(2)O." [EC:2.4.2.14, RHEA:14908]


id: GO:0004045
name: aminoacyl-tRNA hydrolase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: N-substituted aminoacyl-tRNA + H2O = N-substituted amino acid + tRNA." [EC:3.1.1.29]


id: GO:0004046
name: aminoacylase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: an N-acyl-L-amino acid + H2O = a carboxylate + an L-amino acid." [EC:3.5.1.14]


id: GO:0004047
name: aminomethyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: (6S)-tetrahydrofolate + S-aminomethyldihydrolipoylprotein = (6R)-5,10-methylenetetrahydrofolate + NH3 + dihydrolipoylprotein." [EC:2.1.2.10]


id: GO:0004048
name: anthranilate phosphoribosyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: N-(5-phospho-beta-D-ribosyl)anthranilate + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + anthranilate." [EC:2.4.2.18, RHEA:11771]


id: GO:0004049
name: anthranilate synthase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate." [EC:4.1.3.27]


id: GO:0004050
name: obsolete apyrase activity
namespace: molecular_function
def:
  "OBSOLETE. Catalysis of the reaction: ATP + 2 H2O = AMP + 2 phosphate." [EC:3.6.1.5, MetaCyc:APYRASE-RXN]


id: GO:0004051
name: arachidonate 5-lipoxygenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: arachidonate + O2 = (6E,8Z,11Z,14Z)-(5S)-5-hydroperoxycosa-6,8,11,14-tetraenoate." [EC:1.13.11.34]


id: GO:0004052
name: arachidonate 12-lipoxygenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: arachidonate + O(2) = (5Z,8Z,10E,12S,14Z)-12-hydroperoxyicosa-5,8,10,14-tetraenoate." [EC:1.13.11.31, RHEA:10431]


id: GO:0004054
name: arginine kinase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: L-arginine + ATP = N(omega)-phospho-L-arginine + ADP + 2 H(+)." [EC:2.7.3.3, RHEA:22943]


id: GO:0004055
name: argininosuccinate synthase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: ATP + L-citrulline + L-aspartate = AMP + diphosphate + (N(omega)-L-arginino)succinate." [EC:6.3.4.5]


id: GO:0004059
name: aralkylamine N-acetyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: acetyl-CoA + an aralkylamine = CoA + an N-acetylaralkylamine." [EC:2.3.1.87]


id: GO:0004062
name: aryl sulfotransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + a phenol = adenosine 3',5'-bisphosphate + an aryl sulfate." [EC:2.8.2.1]


id: GO:0004063
name: aryldialkylphosphatase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: aryl dialkyl phosphate + H2O = dialkyl phosphate + an aryl alcohol." [EC:3.1.8.1]


id: GO:0004066
name: asparagine synthase (glutamine-hydrolyzing) activity
namespace: molecular_function
def:
  "Catalysis of the reaction: ATP + L-aspartate + L-glutamine = AMP + diphosphate + L-asparagine + L-glutamate." [EC:6.3.5.4]


id: GO:0004069
name: L-aspartate:2-oxoglutarate aminotransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate." [EC:2.6.1.1]


id: GO:0004070
name: aspartate carbamoyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: L-aspartate + carbamoyl phosphate = N-carbamoyl-L-aspartate + H(+) + phosphate." [EC:2.1.3.2, RHEA:20016]


id: GO:0004071
name: aspartate-ammonia ligase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: ATP + L-aspartate + NH3 = AMP + diphosphate + L-asparagine." [EC:6.3.1.1]


id: GO:0004072
name: aspartate kinase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: L-aspartate + ATP = 4-phospho-L-aspartate + ADP + H(+)." [EC:2.7.2.4, RHEA:23779]


id: GO:0004073
name: aspartate-semialdehyde dehydrogenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: L-aspartate 4-semialdehyde + NADP(+) + phosphate = 4-phospho-L-aspartate + H(+) + NADPH." [EC:1.2.1.11, RHEA:24287]


id: GO:0004075
name: biotin carboxylase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: ATP + biotin-carboxyl-carrier protein + CO2 = ADP + phosphate + carboxybiotin-carboxyl-carrier protein." [EC:6.3.4.14]


id: GO:0004076
name: biotin synthase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 2 S-adenosyl-L-methionine + dethiobiotin + S(2-) = 2 5'-deoxyadenosine + 2 L-methionine + biotin + H(+)." [EC:2.8.1.6, RHEA:22063]


id: GO:0004077
name: biotin-[acetyl-CoA-carboxylase] ligase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: ATP + biotin + apo-(acetyl-CoA:carbon-dioxide ligase (ADP forming)) = AMP + diphosphate + (acetyl-CoA:carbon-dioxide ligase (ADP forming))." [EC:6.3.4.15]


id: GO:0004078
name: biotin-[methylcrotonoyl-CoA-carboxylase] ligase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: ATP + biotin + apo-(3-methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming)) = AMP + diphosphate + (3-methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming))." [EC:6.3.4.11]


id: GO:0004079
name: biotin-[methylmalonyl-CoA-carboxytransferase] ligase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: ATP + biotin + apo-(methylmalonyl-CoA:pyruvate carboxytransferase) = AMP + diphosphate + (methylmalonyl-CoA:pyruvate carboxytransferase)." [EC:6.3.4.9]


id: GO:0004080
name: biotin-[propionyl-CoA-carboxylase (ATP-hydrolyzing)] ligase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: ATP + biotin + apo-(propanoyl-CoA:carbon-dioxide ligase (ADP-forming)) = AMP + diphosphate + (propanoyl-CoA:carbon-dioxide ligase (ADP-forming))." [EC:6.3.4.10]


id: GO:0004081
name: bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity
namespace: molecular_function
def:
  "Catalysis of the reaction: P(1),P(4)-bis(5'-nucleosyl)tetraphosphate + H2O = NTP + NMP. Acts on bis(5'-guanosyl)-, bis(5'-xanthosyl)-, bis(5'-adenosyl)- and bis(5'-uridyl)-tetraphosphate." [EC:3.6.1.17, PMID:4955726]


id: GO:0004082
name: bisphosphoglycerate mutase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 3-phospho-D-glyceroyl phosphate = 2,3-bisphospho-D-glycerate." [EC:5.4.2.4]


id: GO:0004083
name: bisphosphoglycerate 2-phosphatase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 2,3-bisphospho-D-glycerate + H(2)O = 3-phospho-D-glycerate + phosphate." [EC:3.1.3.13, RHEA:21907]


id: GO:0004084
name: branched-chain-amino-acid transaminase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: a branched-chain amino acid + 2-oxoglutarate = L-glutamate + a 2-oxocarboxylate derived from the branched-chain amino acid." [EC:2.6.1.42, GOC:mah]


id: GO:0004085
name: butyryl-CoA dehydrogenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: butanoyl-CoA + electron-transfer flavoprotein = 2-butenoyl-CoA + reduced electron-transfer flavoprotein." [EC:1.3.8.1]


id: GO:0004086
name: obsolete carbamoyl-phosphate synthase activity
namespace: molecular_function
def:
  "OBSOLETE. Catalysis of a reaction that results in the formation of carbamoyl phosphate." [EC:6.3.4.16, EC:6.3.5.5, GOC:mah]


id: GO:0004087
name: carbamoyl-phosphate synthase (ammonia) activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 2 ATP + CO(2) + H(2)O + NH(4)(+) = 2 ADP + carbamoyl phosphate + 5 H(+) + phosphate." [EC:6.3.4.16, RHEA:10627]


id: GO:0004088
name: carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 2 ATP + L-glutamine + CO2 + H2O = 2 ADP + phosphate + glutamate + carbamoyl phosphate." [EC:6.3.5.5]


id: GO:0004092
name: carnitine O-acetyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: acetyl-CoA + carnitine = (R)-O-acetylcarnitine + CoA." [EC:2.3.1.7, RHEA:21139]


id: GO:0004095
name: carnitine O-palmitoyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: palmitoyl-CoA + L-carnitine = CoA + L-palmitoylcarnitine." [EC:2.3.1.21]


id: GO:0004100
name: chitin synthase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + [->4)-N-acetyl-beta-D-glucosaminyl-(1-](n) = UDP + [->4)-N-acetyl-beta-D-glucosaminyl-(1-](n+1)." [EC:2.4.1.16]


id: GO:0004103
name: choline kinase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: ATP + choline = ADP + choline phosphate + 2 H(+)." [EC:2.7.1.32, RHEA:12840]


id: GO:0004107
name: chorismate synthase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 5-O-(1-carboxyvinyl)-3-phosphoshikimate = chorismate + phosphate." [EC:4.2.3.5, RHEA:21023]


id: GO:0004108
name: citrate (Si)-synthase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: acetyl-CoA + H2O + oxaloacetate = citrate + CoA, where the acetyl group is added to the si-face of oxaloacetate; acetyl-CoA thus provides the two carbon atoms of the pro-S carboxymethyl group." [EC:2.3.3.1, ISBN:0121227073]


id: GO:0004109
name: coproporphyrinogen oxidase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: coproporphyrinogen III + 2 H(+) + O(2) = 2 CO(2) + 2 H(2)O + protoporphyrinogen IX." [EC:1.3.3.3, RHEA:18260]


id: GO:0004110
name: corticosteroid side-chain-isomerase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 11-deoxycorticosterone = 20-hydroxy-3-oxopregn-4-en-21-al." [EC:5.3.1.21, RHEA:17864]


id: GO:0004111
name: creatine kinase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: ATP + creatine = N-phosphocreatine + ADP + 2 H(+)." [EC:2.7.3.2, RHEA:17160]


id: GO:0004112
name: cyclic-nucleotide phosphodiesterase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: a nucleoside cyclic phosphate + H2O = a nucleoside phosphate." [GOC:mah]


id: GO:0004113
name: 2',3'-cyclic-nucleotide 3'-phosphodiesterase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: nucleoside 2',3'-cyclic phosphate + H2O = nucleoside 2'-phosphate." [EC:3.1.4.37]


id: GO:0004114
name: 3',5'-cyclic-nucleotide phosphodiesterase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate." [EC:3.1.4.17]


id: GO:0004115
name: 3',5'-cyclic-AMP phosphodiesterase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: adenosine 3',5'-cyclic phosphate + H2O = adenosine 5'-phosphate." [GOC:ai]


id: GO:0004117
name: calmodulin-dependent cyclic-nucleotide phosphodiesterase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate; catalytic activity is regulated by calmodulin." [GOC:mah]


id: GO:0004118
name: cGMP-stimulated cyclic-nucleotide phosphodiesterase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate; catalytic activity is increased in the presence of cGMP." [GOC:mah]


id: GO:0004119
name: cGMP-inhibited cyclic-nucleotide phosphodiesterase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate; catalytic activity is decreased in the presence of cGMP." [GOC:mah]


id: GO:0004120
name: photoreceptor cyclic-nucleotide phosphodiesterase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: nucleoside cyclic phosphate + H2O = nucleoside phosphate. This reaction is the hydrolysis of bonds in a cyclic nucleotide." [EC:3.1.4.-]


id: GO:0004123
name: cystathionine gamma-lyase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: L-cystathionine + H2O = 2-oxobutanoate + L-cysteine + NH4+." [RHEA:24918]


id: GO:0004124
name: cysteine synthase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: O3-acetyl-L-serine + hydrogen sulfide = L-cysteine + acetate." [EC:4.2.99.8]


id: GO:0004125
name: L-seryl-tRNASec selenium transferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: L-seryl-tRNA(Sec) + selenophosphate = L-selenocysteinyl-tRNA(Sec) + H2O + phosphate." [EC:2.9.1.1]


id: GO:0004128
name: cytochrome-b5 reductase activity, acting on NAD(P)H
namespace: molecular_function
def:
  "Catalysis of the reaction: NAD(P)H + H+ + 2 ferricytochrome b(5) = NAD(P)+ + 2 ferrocytochrome b(5)." [EC:1.6.2.2, ISBN:0198547684]


id: GO:0004129
name: cytochrome-c oxidase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O." [EC:1.9.3.1]


id: GO:0004130
name: cytochrome-c peroxidase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 2 ferrocytochrome c + hydrogen peroxide = 2 ferricytochrome c + 2 H2O." [EC:1.11.1.5]


id: GO:0004134
name: 4-alpha-glucanotransferase activity
namespace: molecular_function
def:
  "Catalysis of the transfer of a segment of a (1->4)-alpha-D-glucan to a new 4-position in an acceptor, which may be glucose or (1->4)-alpha-D-glucan." [EC:2.4.1.25]


id: GO:0004135
name: amylo-alpha-1,6-glucosidase activity
namespace: molecular_function
def:
  "Catalysis of the hydrolysis of (1->6)-alpha-D-glucosidic branch linkages in glycogen phosphorylase limit dextrin. Limit dextrin is the highly branched core that remains after exhaustive treatment of glycogen with glycogen phosphorylase. It is formed because these enzymes cannot hydrolyze the (1->6) glycosidic linkages present." [EC:3.2.1.33, ISBN:0198506732]


id: GO:0004136
name: deoxyadenosine kinase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 2'-deoxyadenosine + ATP = ADP + dAMP + 2 H(+)." [EC:2.7.1.76, RHEA:23455]


id: GO:0004138
name: deoxyguanosine kinase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 2'-deoxyguanosine + ATP = ADP + dGMP + 2 H(+)." [EC:2.7.1.113, RHEA:19204]


id: GO:0004139
name: deoxyribose-phosphate aldolase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 2-deoxy-D-ribose 5-phosphate = D-glyceraldehyde 3-phosphate + acetaldehyde." [EC:4.1.2.4, RHEA:12824]


id: GO:0004141
name: dethiobiotin synthase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 7,8-diaminononanoate + ATP + CO(2) = ADP + dethiobiotin + 4 H(+) + phosphate." [EC:6.3.3.3, RHEA:15808]


id: GO:0004142
name: diacylglycerol cholinephosphotransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: CDP-choline + 1,2-diacylglycerol = CMP + a phosphatidylcholine." [EC:2.7.8.2]


id: GO:0004143
name: diacylglycerol kinase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: NTP + 1,2-diacylglycerol = NDP + 1,2-diacylglycerol-3-phosphate." [EC:2.7.1.107, GOC:elh]


id: GO:0004145
name: diamine N-acetyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: acetyl-CoA + an alkane-alpha,omega-diamine = CoA + an N-acetyldiamine." [EC:2.3.1.57]


id: GO:0004146
name: dihydrofolate reductase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 5,6,7,8-tetrahydrofolate + NADP+ = 7,8-dihydrofolate + NADPH + H+." [EC:1.5.1.3]


id: GO:0004147
name: dihydrolipoamide branched chain acyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: acyl-CoA + dihydrolipoamide = CoA + S-acyldihydrolipoamide, where the acyl group is a branched chain." [GOC:mah]


id: GO:0004148
name: dihydrolipoyl dehydrogenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: protein N6-(dihydrolipoyl)lysine + NAD+ = protein N6-(lipoyl)lysine + NADH + H+." [EC:1.8.1.4]


id: GO:0004149
name: dihydrolipoyllysine-residue succinyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: succinyl-CoA + dihydrolipoamide = CoA + S-succinyldihydrolipoamide." [EC:2.3.1.61]


id: GO:0004150
name: dihydroneopterin aldolase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 2-amino-4-hydroxy-6-(D-erythro-1,2,3-trihydroxypropyl)-7,8-dihydropteridine = 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine + glycolaldehyde." [EC:4.1.2.25]


id: GO:0004151
name: dihydroorotase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: (S)-dihydroorotate + H(2)O = N-carbamoyl-L-aspartate + H(+)." [EC:3.5.2.3, RHEA:24299]


id: GO:0004153
name: dihydropterin deaminase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 7,8-dihydropterin + H2O = 7,8-dihydrolumazine + NH3." [FB:FBrf0039640, GOC:jl, http://www.abbs.info/fulltxt/eng/35030306.htm, ISSN:05829879]


id: GO:0004154
name: dihydropterin oxidase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: a 7,8-dihydropteridine + O2 = a pterin + hydrogen peroxide." [GOC:mah, PMID:1745247, PMID:6815189]


id: GO:0004155
name: 6,7-dihydropteridine reductase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: NADP+ + 5,6,7,8-tetrahydropteridine = NADPH + H+ + 6,7-dihydropteridine." [EC:1.5.1.34]


id: GO:0004156
name: dihydropteroate synthase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate + 4-aminobenzoate = diphosphate + dihydropteroate." [EC:2.5.1.15]


id: GO:0004158
name: dihydroorotate oxidase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: (S)-dihydroorotate + O(2) = H(2)O(2) + orotate." [EC:1.3.3.1, RHEA:15444]


id: GO:0004160
name: dihydroxy-acid dehydratase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 2,3-dihydroxy-3-methylbutanoate = 3-methyl-2-oxobutanoate + H2O." [EC:4.2.1.9]


id: GO:0004161
name: dimethylallyltranstransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: dimethylallyl diphosphate + isopentenyl diphosphate = diphosphate + geranyl diphosphate." [EC:2.5.1.1]


id: GO:0004163
name: diphosphomevalonate decarboxylase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: (R)-5-diphosphomevalonate + ATP = ADP + CO(2) + H(+) + isopentenyl diphosphate + phosphate." [EC:4.1.1.33, RHEA:23735]


id: GO:0004164
name: diphthine synthase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: S-adenosyl-L-methionine + 2-(3-carboxy-3-aminopropyl)-L-histidine = S-adenosyl-L-homocysteine + 2-(3-carboxy-3-(methylammonio)propyl)-L-histidine." [EC:2.1.1.98]


id: GO:0004166
name: dolichyl-phosphate alpha-N-acetylglucosaminyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + dolichyl phosphate = UDP + dolichyl N-acetyl-alpha-D-glucosaminyl phosphate." [EC:2.4.1.153]


id: GO:0004167
name: dopachrome isomerase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: L-dopachrome = 5,6-dihydroxyindole-2-carboxylate." [EC:5.3.3.12, RHEA:13044]


id: GO:0004169
name: dolichyl-phosphate-mannose-protein mannosyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: dolichyl phosphate D-mannose + protein = dolichyl phosphate + O-D-mannosylprotein." [EC:2.4.1.109, GOC:pr]


id: GO:0004171
name: obsolete deoxyhypusine synthase activity
namespace: molecular_function
def:
  "OBSOLETE. Catalysis of the reaction: [eIF5A-precursor]-lysine + spermidine = [eIF5A-precursor]-deoxyhypusine + propane-1,3-diamine." [EC:2.5.1.46]


id: GO:0004173
name: ecdysone O-acyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: Ecdysone + palmitoyl-CoA = CoA + ecdysone palmitate." [EC:2.3.1.139, RHEA:15220]


id: GO:0004175
name: endopeptidase activity
namespace: molecular_function
def:
  "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain." [http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE]


id: GO:0004176
name: ATP-dependent peptidase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the hydrolysis of peptide bonds." [GOC:mah]


id: GO:0004177
name: aminopeptidase activity
namespace: molecular_function
def:
  "Catalysis of the hydrolysis of N-terminal amino acid residues from in a polypeptide chain." [GOC:jl, ISBN:0198506732]


id: GO:0004178
name: obsolete leucyl aminopeptidase activity
namespace: molecular_function
def:
  "OBSOLETE. Catalysis of the release of an N-terminal amino acid, Xaa-Xbb-, in which Xaa is preferably Leu, but may be other amino acids including Pro although not Arg or Lys, and Xbb may be Pro." [EC:3.4.11.1]


id: GO:0004179
name: obsolete membrane alanyl aminopeptidase activity
namespace: molecular_function
def:
  "OBSOLETE. Catalysis of the release of an N-terminal amino acid, Xaa-Xbb- from a peptide, amide or arylamide. Xaa is preferably Ala, but may be most amino acids including Pro (slow action). When a terminal hydrophobic residue is followed by a prolyl residue, the two may be released as an intact Xaa-Pro dipeptide." [EC:3.4.11.2]


id: GO:0004180
name: carboxypeptidase activity
namespace: molecular_function
def:
  "Catalysis of the hydrolysis of the terminal or penultimate peptide bond at the C-terminal end of a peptide or polypeptide." [ISBN:0198506732]


id: GO:0004181
name: metallocarboxypeptidase activity
namespace: molecular_function
def:
  "Catalysis of the hydrolysis of C-terminal amino acid residues from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [http://merops.sanger.ac.uk/about/glossary.htm#CARBOXYPEPTIDASE, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0198506732]


id: GO:0004182
name: obsolete carboxypeptidase A activity
namespace: molecular_function
def:
  "OBSOLETE. Catalysis of the reaction: peptidyl-L-amino acid + H2O = peptide + L-amino acid. Little or no action with -Asp, -Glu, -Arg, -Lys or -Pro." [EC:3.4.17.1]


id: GO:0004183
name: obsolete carboxypeptidase E activity
namespace: molecular_function
def:
  "OBSOLETE. Catalysis of the reaction: peptidyl-L-lysine (or peptidyl-L-arginine) + H2O = peptide + L-lysine (or L-arginine). Function is activated by Co2+ and inhibited by 1,10-phenanthroline and other chelating agents." [EC:3.4.17.10]


id: GO:0004184
name: obsolete lysine carboxypeptidase activity
namespace: molecular_function
def:
  "OBSOLETE. Catalysis of the reaction: peptidyl-L-lysine (or peptidyl-L-arginine) + H2O = peptide + L-lysine (or L-arginine). Release of a C-terminal basic amino acid, preferentially lysine; inactivates bradykinin and anaphylatoxins in blood plasma." [EC:3.4.17.3]


id: GO:0004185
name: serine-type carboxypeptidase activity
namespace: molecular_function
def:
  "Catalysis of the hydrolysis of a peptide bond not more than three residues from the C-terminus of a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [http://merops.sanger.ac.uk/about/glossary.htm#CARBOXYPEPTIDASE, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]


id: GO:0004186
name: obsolete carboxypeptidase C activity
namespace: molecular_function
def:
  "OBSOLETE. Catalysis of the release of a C-terminal amino acid with a broad specificity." [EC:3.4.16.5]


id: GO:0004187
name: obsolete carboxypeptidase D activity
namespace: molecular_function
def:
  "OBSOLETE. Catalysis of the preferential release of a C-terminal arginine or lysine residue. Function is inhibited by diisopropyl fluorophosphate and sensitive to thiol-blocking reagents." [EC:3.4.16.6]


id: GO:0004188
name: obsolete serine-type Pro-X carboxypeptidase activity
namespace: molecular_function
def:
  "OBSOLETE. Catalysis of the cleavage of a Pro-Xaa bond by a serine-type peptidase mechanism to release a C-terminal amino acid." [EC:3.4.16.2]


id: GO:0004189
name: obsolete tubulinyl-Tyr carboxypeptidase activity
namespace: molecular_function
def:
  "OBSOLETE. Catalysis of the cleavage of the Glu-Tyr bond to release the C-terminal tyrosine residue from the native tyrosinated tubulin. Inactive on Z-Glu-Tyr." [EC:3.4.17.17]


id: GO:0004190
name: aspartic-type endopeptidase activity
namespace: molecular_function
def:
  "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile." [ISBN:0198506732]


id: GO:0004191
name: obsolete barrierpepsin activity
namespace: molecular_function
def:
  "OBSOLETE. Catalysis of the selected cleavage of the Leu6-Lys7 bond in the pheromone alpha-mating factor." [EC:3.4.23.35]


id: GO:0004192
name: obsolete cathepsin D activity
namespace: molecular_function
def:
  "OBSOLETE. Catalysis of the hydrolysis of peptide bonds. Specificity similar to, but narrower than, that of pepsin A. Does not cleave the Gln4-His5 bond in the B chain of insulin." [EC:3.4.23.5]


id: GO:0004193
name: obsolete cathepsin E activity
namespace: molecular_function
def:
  "OBSOLETE. Catalysis of the hydrolysis of peptide bonds. Similar to cathepsin D, but slightly broader specificity." [EC:3.4.23.34]


id: GO:0004194
name: obsolete pepsin A activity
namespace: molecular_function
def:
  "OBSOLETE. Catalysis of the hydrolysis of peptide bonds. Preferential cleavage: hydrophobic, preferably aromatic, residues in P1 and P1' positions. Cleaves Phe1-Val2, Gln4-His5, Glu13-Ala14, Ala14-Leu15, Leu15-Tyr16, Tyr16-Leu17, Gly23-Phe24, Phe24-Phe25 and Phe25-Tyr26 bonds in the B chain of insulin." [EC:3.4.23.1]


id: GO:0004195
name: obsolete renin activity
namespace: molecular_function
def:
  "OBSOLETE. Catalysis of the cleavage of Leu-Xaa bond in angiotensinogen to generate angiotensin I." [EC:3.4.23.15]


id: GO:0004196
name: obsolete saccharopepsin activity
namespace: molecular_function
def:
  "OBSOLETE. Catalysis of the degradation of gelatin; little activity on hemoglobin. Specificity on B chain of insulin more restricted than pepsin A; does not cleave Phe1-Val2, Gln4-His5 or Gly23-Phe24." [EC:3.4.23.25]


id: GO:0004197
name: cysteine-type endopeptidase activity
namespace: molecular_function
def:
  "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE]


id: GO:0004198
name: calcium-dependent cysteine-type endopeptidase activity
namespace: molecular_function
def:
  "Catalysis of the hydrolysis of nonterminal peptide bonds in a polypeptide chain by a mechanism using a cysteine residue at the enzyme active center, and requiring the presence of calcium." [GOC:mah]


id: GO:0004201
name: obsolete caspase-1 activity
namespace: molecular_function
def:
  "OBSOLETE. Catalysis of the release of interleukin 1-beta by specific cleavage of Asp116-Ala117 and Asp27-Gly28 bonds in precursor. Enzymes with this function can also hydrolyze the terminal bond in the small-molecule substrate, Ac-Tyr-Val-Ala-Asp-NHMec." [EC:3.4.22.36]


id: GO:0004208
name: obsolete caspase-3 activity
namespace: molecular_function
def:
  "OBSOLETE. Catalysis of the cleavage at the terminal bond of the motif: Asp-Xaa-Xaa-Asp-Xaa. Enzymes with this function are members of the peptidase family C14 and they appear to function in the inactivation of proteins involved in cellular repair and homeostasis during the effector stage of apoptosis." [ISBN:0120793709]


id: GO:0004213
name: obsolete cathepsin B activity
namespace: molecular_function
def:
  "OBSOLETE. Catalysis of the hydrolysis of peptide bonds with a broad specificity. Preferentially cleaves the terminal bond of -Arg-Arg-Xaa motifs in small molecule substrates (thus differing from cathepsin L). In addition to being an endopeptidase, shows peptidyl-dipeptidase activity, liberating C-terminal dipeptides." [EC:3.4.22.1]


id: GO:0004214
name: obsolete dipeptidyl-peptidase I activity
namespace: molecular_function
def:
  "OBSOLETE. Catalysis of the release of an N-terminal dipeptide, Xaa-Xbb from Xaa-Xbb-Xcc, except when Xaa is Arg or Lys, or Xbb or Xcc is Pro." [EC:3.4.14.1]


id: GO:0004215
name: obsolete cathepsin H activity
namespace: molecular_function
def:
  "OBSOLETE. Catalysis of the hydrolysis of peptide bonds, acting as an aminopeptidase (notably, cleaving Arg-Xaa bonds) as well as an endopeptidase." [EC:3.4.22.16]


id: GO:0004216
name: obsolete cathepsin K activity
namespace: molecular_function
def:
  "OBSOLETE. Catalysis of the hydrolysis of peptide bonds. Has a broad proteolytic activity. With small-molecule substrates and inhibitors, the major determinant of specificity is P2, which is preferably Leu, Met > Phe, and not Arg." [EC:3.4.22.38]


id: GO:0004217
name: obsolete cathepsin L activity
namespace: molecular_function
def:
  "OBSOLETE. Catalysis of the hydrolysis of peptide bonds. Specificity close to that of papain. As compared to cathepsin B, cathepsin L exhibits higher activity towards protein substrates, but has little activity on Z-Arg-Arg-NHMec, and no peptidyl-dipeptidase activity." [EC:3.4.22.15]


id: GO:0004218
name: obsolete cathepsin S activity
namespace: molecular_function
def:
  "OBSOLETE. Catalysis of the hydrolysis of peptide bonds. Similar to cathepsin L, but with much less activity on the terminal bond of Z-Phe-Arg-NHMec, and more activity on the terminal bond of Z-Val-Val-Arg-Xaa compounds." [EC:3.4.22.27]


id: GO:0004219
name: obsolete pyroglutamyl-peptidase I activity
namespace: molecular_function
def:
  "OBSOLETE. Catalysis of the reaction: pyroglutamyl-peptide + H2O = pyroglutamate + peptide." [EC:3.4.19.3]


id: GO:0004221
name: obsolete ubiquitin thiolesterase activity
namespace: molecular_function
def:
  "OBSOLETE. Catalysis of the reaction: ubiquitin C-terminal thioester + H2O = ubiquitin + a thiol." [EC:3.1.2.15, GOC:jh2]


id: GO:0004222
name: metalloendopeptidase activity
namespace: molecular_function
def:
  "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE]


id: GO:0004228
name: obsolete gelatinase A activity
namespace: molecular_function
def:
  "OBSOLETE. Catalysis of the cleavage of gelatin type I and collagen types IV, V, VII, X. Cleaves the collagen-like sequence Pro-Gln-Gly-Ile-Ala-Gly-Gln at the Gly-Ile bond." [EC:3.4.24.24]


id: GO:0004229
name: obsolete gelatinase B activity
namespace: molecular_function
def:
  "OBSOLETE. Catalysis of the cleavage of gelatin types I and V and collagen types IV and V." [EC:3.4.24.35]


id: GO:0004230
name: obsolete glutamyl aminopeptidase activity
namespace: molecular_function
def:
  "OBSOLETE. Catalysis of the release of a N-terminal glutamate (and to a lesser extent aspartate) from a peptide." [EC:3.4.11.7]


id: GO:0004231
name: obsolete insulysin activity
namespace: molecular_function
def:
  "OBSOLETE. Catalysis of the degradation of insulin, glucagon and other polypeptides. No action on proteins." [EC:3.4.24.56]


id: GO:0004232
name: obsolete interstitial collagenase activity
namespace: molecular_function
def:
  "OBSOLETE. Catalysis of the preferential cleavage of one bond in native collagen. Cleavage of the triple helix of collagen at about three-quarters of the length of the molecule from the N-terminus, at Gly775-Ile776 in the alpha-1(I) chain. Cleaves synthetic substrates and alpha-macroglobulins at bonds where P1' is a hydrophobic residue." [EC:3.4.24.7]


id: GO:0004234
name: obsolete macrophage elastase activity
namespace: molecular_function
def:
  "OBSOLETE. Catalysis of the hydrolysis of soluble and insoluble elastin. Specific cleavages are also produced at Ala14-Leu15 and Tyr16-Leu17 in the B chain of insulin." [EC:3.4.24.65]


id: GO:0004235
name: obsolete matrilysin activity
namespace: molecular_function
def:
  "OBSOLETE. Catalysis of the cleavage of Ala14-Leu15 and Tyr16-Leu17 in B chain of insulin. No action on collagen types I, II, IV and V. Cleaves gelatin chain alpha-2(I) > alpha-1(I)." [EC:3.4.24.23]


id: GO:0004238
name: obsolete meprin A activity
namespace: molecular_function
def:
  "OBSOLETE. Catalysis of the hydrolysis of protein and peptide substrates preferentially on carboxyl side of hydrophobic residues." [EC:3.4.24.18]


id: GO:0004239
name: obsolete methionyl aminopeptidase activity
namespace: molecular_function
def:
  "OBSOLETE. Catalysis of the release of N-terminal amino acids, preferentially methionine, from peptides and arylamides." [EC:3.4.11.18]


id: GO:0004240
name: obsolete mitochondrial processing peptidase activity
namespace: molecular_function
def:
  "OBSOLETE. Catalysis of the release of N-terminal transit peptides from precursor proteins imported into the mitochondrion, typically with Arg in position P2." [EC:3.4.24.64]


id: GO:0004243
name: obsolete mitochondrial intermediate peptidase activity
namespace: molecular_function
def:
  "OBSOLETE. Catalysis of the release of an N-terminal octapeptide as second stage of processing of some proteins imported in the mitochondrion." [EC:3.4.24.59]


id: GO:0004244
name: obsolete mitochondrial inner membrane peptidase activity
namespace: molecular_function
def:
  "OBSOLETE. Catalysis of the maturation of mitochondrial precursor proteins delivered to the intermembrane space." [PMID:12191769]


id: GO:0004245
name: obsolete neprilysin activity
namespace: molecular_function
def:
  "OBSOLETE. Catalysis of the preferential cleavage at the amino group of hydrophobic residues in insulin, casein, hemoglobin, and a number of other proteins and polypeptides." [EC:3.4.24.11]


id: GO:0004246
name: obsolete peptidyl-dipeptidase A activity
namespace: molecular_function
def:
  "OBSOLETE. Catalysis of the release of a C-terminal dipeptide, Xaa-Xbb from oligopeptide-Xaa-Xbb, when Xaa is not Pro, and Xbb is neither Asp nor Glu. Converts angiotensin I to angiotensin II." [EC:3.4.15.1]


id: GO:0004248
name: obsolete stromelysin 1 activity
namespace: molecular_function
def:
  "OBSOLETE. Catalysis of the preferential cleavage where P1', P2' and P3' are hydrophobic residues." [EC:3.4.24.17]


id: GO:0004250
name: obsolete aminopeptidase I activity
namespace: molecular_function
def:
  "OBSOLETE. Catalysis of the release of an N-terminal amino acid, preferably a neutral or hydrophobic one, from a polypeptide. Aminoacyl-arylamides are poor substrates." [EC:3.4.11.22]


id: GO:0004251
name: obsolete X-Pro dipeptidase activity
namespace: molecular_function
def:
  "OBSOLETE. Catalysis of the hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on Pro-Pro." [EC:3.4.13.9]


id: GO:0004252
name: serine-type endopeptidase activity
namespace: molecular_function
def:
  "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094]


id: GO:0004253
name: obsolete gamma-renin activity
namespace: molecular_function
def:
  "OBSOLETE. Catalysis of the cleavage of the Leu-Leu bond in synthetic tetradecapeptide renin substrate, producing angiotensin I, but not active on natural angiotensinogen. Also hydrolyzes BZ-Arg-para-nitroanilide." [EC:3.4.21.54]


id: GO:0004254
name: obsolete acylaminoacyl-peptidase activity
namespace: molecular_function
def:
  "OBSOLETE. Catalysis of the reaction: acylaminoacyl-peptide + H2O = acylamino acid + peptide." [EC:3.4.19.1]


id: GO:0004261
name: obsolete cathepsin G activity
namespace: molecular_function
def:
  "OBSOLETE. Catalysis of the hydrolysis of peptide bonds. Specificity similar to chymotrypsin C." [EC:3.4.21.20]


id: GO:0004262
name: obsolete cerevisin activity
namespace: molecular_function
def:
  "OBSOLETE. Catalysis of the hydrolysis of proteins with broad specificity, and of BZ-Arg-OET > Ac-Tyr-OET. Does not hydrolyze peptide amides." [EC:3.4.21.48]


id: GO:0004263
name: obsolete chymotrypsin activity
namespace: molecular_function
def:
  "OBSOLETE. Catalysis of the preferential cleavage of Tyr-Xaa > Trp-Xaa > Phe-Xaa > Leu-Xaa." [EC:3.4.21.1, ISBN:0198506732]


id: GO:0004274
name: obsolete dipeptidyl-peptidase IV activity
namespace: molecular_function
def:
  "OBSOLETE. Catalysis of the release of an N-terminal dipeptide, by the hydrolysis of the Xbb-Xcc bond in Xaa-Xbb-Xcc, preferentially when Xbb is Pro, provided Xcc is neither Pro nor hydroxyproline." [EC:3.4.14.5]


id: GO:0004276
name: obsolete furin activity
namespace: molecular_function
def:
  "OBSOLETE. Catalysis of the release of mature proteins from their proproteins by cleavage of the terminal bond of Arg-Xaa-Yaa-Arg-Z motifs where Xaa can be any amino acid and Yaa is Arg or Lys. Releases albumin, complement component C3 and von Willebrand factor from their respective precursors." [EC:3.4.21.75]


id: GO:0004277
name: obsolete granzyme A activity
namespace: molecular_function
def:
  "OBSOLETE. Catalysis of the hydrolysis of proteins, including fibronectin, type IV collagen and nucleolin. Preferential cleavage: Arg-Xaa > Lys-Xaa > Phe-Xaa in small molecule substrates." [EC:3.4.21.78]


id: GO:0004278
name: obsolete granzyme B activity
namespace: molecular_function
def:
  "OBSOLETE. Catalysis of the preferential cleavage of Asp-Xaa > Asn-Xaa > Met-Xaa, Ser-Xaa." [EC:3.4.21.79]


id: GO:0004281
name: obsolete pancreatic elastase II activity
namespace: molecular_function
def:
  "OBSOLETE. Catalysis of the preferential cleavage of Leu-Xaa, Met-Xaa and Phe-Xaa. Hydrolyzes elastin." [EC:3.4.21.71]


id: GO:0004283
name: obsolete plasmin activity
namespace: molecular_function
def:
  "OBSOLETE. Catalysis of the preferential cleavage of Lys-Xaa > Arg-Xaa; higher selectivity than trypsin. Converts fibrin into soluble products." [EC:3.4.21.7]


id: GO:0004285
name: obsolete proprotein convertase 1 activity
namespace: molecular_function
def:
  "OBSOLETE. Catalysis of the release of protein hormones, neuropeptides and renin from their precursors, generally by cleavage of -Lys-Arg-Xaa at the Arg-Xaa bond." [EC:3.4.21.93]


id: GO:0004286
name: obsolete proprotein convertase 2 activity
namespace: molecular_function
def:
  "OBSOLETE. Catalysis of the release of protein hormones and neuropeptides from their precursors, generally by cleavage of -Lys-Arg-Xaa at the Arg-Xaa bond." [EC:3.4.21.94]


id: GO:0004290
name: obsolete kexin activity
namespace: molecular_function
def:
  "OBSOLETE. Catalysis of the cleavage of the Arg-Xaa bond in Lys-Arg-Xaa and Arg-Arg-Xaa to process Yeast alpha-factor pheromone and killer toxin precursors." [EC:3.4.21.61]


id: GO:0004291
name: obsolete subtilisin activity
namespace: molecular_function
def:
  "OBSOLETE. Catalysis of the hydrolysis of proteins with broad specificity for peptide bonds, and a preference for a large uncharged residue in P1. Hydrolyzes peptide amides." [EC:3.4.21.62]


id: GO:0004293
name: obsolete tissue kallikrein activity
namespace: molecular_function
def:
  "OBSOLETE. Catalysis of the preferential cleavage of Arg-Xaa bonds in small molecule substrates. Highly selective action to release kallidin (lysyl-bradykinin) from kininogen involves hydrolysis of Met-Xaa or Leu-Xaa. The rat enzyme is unusual in liberating bradykinin directly from autologous kininogens by cleavage at two Arg-Xaa bonds." [EC:3.4.21.35]


id: GO:0004294
name: obsolete tripeptidyl-peptidase II activity
namespace: molecular_function
def:
  "OBSOLETE. Catalysis of the release of an N-terminal tripeptide from a polypeptide at neutral pH." [EC:3.4.14.10]


id: GO:0004298
name: threonine-type endopeptidase activity
namespace: molecular_function
def:
  "Catalysis of the hydrolysis of internal peptide bonds in a polypeptide chain by a mechanism in which the hydroxyl group of a threonine residue at the active center acts as a nucleophile." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE]


id: GO:0004304
name: estrone sulfotransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + estrone = adenosine 3',5'-bisphosphate + estrone 3-sulfate." [EC:2.8.2.4]


id: GO:0004305
name: ethanolamine kinase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: ATP + ethanolamine = ADP + 2 H(+) + phosphoethanolamine." [EC:2.7.1.82, RHEA:13072]


id: GO:0004306
name: ethanolamine-phosphate cytidylyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: CTP + ethanolamine phosphate = diphosphate + CDP-ethanolamine." [EC:2.7.7.14]


id: GO:0004307
name: ethanolaminephosphotransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: CDP-ethanolamine + 1,2-diacylglycerol = CMP + a phosphatidylethanolamine." [EC:2.7.8.1]


id: GO:0004308
name: exo-alpha-sialidase activity
namespace: molecular_function
def:
  "Catalysis of the hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)-glycosidic linkages of terminal sialic residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates." [EC:3.2.1.18]


id: GO:0004310
name: farnesyl-diphosphate farnesyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 2 farnesyl diphosphate = diphosphate + presqualene diphosphate." [EC:2.5.1.21]


id: GO:0004311
name: farnesyltranstransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate + isopentenyl diphosphate = diphosphate + geranylgeranyl diphosphate." [EC:2.5.1.29, RHEA:17656]


id: GO:0004312
name: fatty acid synthase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: acetyl-CoA + n malonyl-CoA + 2n NADPH + 2n H+ = long-chain fatty acid + n+1 CoA + n CO2 + 2n NADP+." [EC:2.3.1.85]


id: GO:0004313
name: [acyl-carrier-protein] S-acetyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: acetyl-CoA + [acyl-carrier protein] = CoA + acetyl-[acyl-carrier protein]." [EC:2.3.1.38]


id: GO:0004314
name: [acyl-carrier-protein] S-malonyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: malonyl-CoA + [acyl-carrier protein] = CoA + malonyl-[acyl-carrier protein]." [EC:2.3.1.39]


id: GO:0004315
name: 3-oxoacyl-[acyl-carrier-protein] synthase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein] = 3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]." [EC:2.3.1.41]


id: GO:0004316
name: 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity
namespace: molecular_function
def:
  "Catalysis of the reaction: (3R)-3-hydroxyacyl-[acyl-carrier protein] + NADP+ = 3-oxoacyl-[acyl-carrier protein] + NADPH + H+." [EC:1.1.1.100]


id: GO:0004317
name: 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: (3R)-3-hydroxypalmitoyl-[acyl-carrier protein] = 2-hexadecenoyl-[acyl-carrier protein] + H2O." [EC:4.2.1.61]


id: GO:0004318
name: enoyl-[acyl-carrier-protein] reductase (NADH) activity
namespace: molecular_function
def:
  "Catalysis of the reaction: acyl-[acyl-carrier protein] + NAD+ = trans-2,3-dehydroacyl-[acyl-carrier protein] + NADH + H+." [EC:1.3.1.9]


id: GO:0004319
name: enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific) activity
namespace: molecular_function
def:
  "Catalysis of the reaction: acyl-[acyl-carrier protein] + NADP+ = trans-2,3-dehydroacyl-[acyl-carrier protein] + NADPH + H+." [EC:1.3.1.10]


id: GO:0004320
name: oleoyl-[acyl-carrier-protein] hydrolase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: oleoyl-[acyl-carrier protein] + H2O = [acyl-carrier protein] + oleate." [EC:3.1.2.14]


id: GO:0004321
name: fatty-acyl-CoA synthase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: acetyl-CoA + n malonyl-CoA + 2n NADH + 2n NADPH + 4n H+ = a long-chain acyl-CoA + n CoA + n CO2 + 2n NAD+ + 2n NADP+." [EC:2.3.1.86]


id: GO:0004324
name: ferredoxin-NADP+ reductase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: reduced ferredoxin + NADP+ = oxidized ferredoxin + NADPH + H+." [EC:1.18.1.2, GOC:kd]


id: GO:0004326
name: tetrahydrofolylpolyglutamate synthase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: ATP + tetrahydrofolyl-(Glu)(n) + L-glutamate = ADP + phosphate + tetrahydrofolyl-(Glu)(n+1)." [EC:6.3.2.17]


id: GO:0004327
name: obsolete formaldehyde dehydrogenase (glutathione) activity
namespace: molecular_function
def:
  "OBSOLETE. Catalysis of the reaction: formaldehyde + glutathione + NAD+ = S-formylglutathione + NADH + H+." [EC:1.2.1.1]


id: GO:0004329
name: formate-tetrahydrofolate ligase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate." [EC:6.3.4.3]


id: GO:0004331
name: fructose-2,6-bisphosphate 2-phosphatase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: D-fructose 2,6-bisphosphate + H2O = D-fructose-6-phosphate + phosphate." [EC:3.1.3.46]


id: GO:0004332
name: fructose-bisphosphate aldolase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde-3-phosphate." [EC:4.1.2.13]


id: GO:0004334
name: fumarylacetoacetase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 4-fumarylacetoacetate + H(2)O = acetoacetate + fumarate + H(+)." [EC:3.7.1.2, RHEA:10247]


id: GO:0004335
name: galactokinase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: D-galactose + ATP = alpha-D-galactose 1-phosphate + ADP + 2 H(+)." [EC:2.7.1.6, RHEA:13556]


id: GO:0004336
name: galactosylceramidase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: D-galactosyl-N-acylsphingosine + H2O = D-galactose + N-acylsphingosine." [EC:3.2.1.46]


id: GO:0004337
name: geranyltranstransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: geranyl diphosphate + isopentenyl diphosphate = 2-trans,6-trans-farnesyl diphosphate + diphosphate." [EC:2.5.1.10, RHEA:19364]


id: GO:0004338
name: glucan exo-1,3-beta-glucosidase activity
namespace: molecular_function
def:
  "Catalysis of the successive hydrolysis of beta-D-glucose units from the non-reducing ends of (1->3)-beta-D-glucans, releasing alpha-glucose." [EC:3.2.1.58]


id: GO:0004339
name: glucan 1,4-alpha-glucosidase activity
namespace: molecular_function
def:
  "Catalysis of the hydrolysis of terminal (1->4)-linked alpha-D-glucose residues successively from non-reducing ends of the chains with release of beta-D-glucose." [EC:3.2.1.3]


id: GO:0004342
name: glucosamine-6-phosphate deaminase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: D-glucosamine 6-phosphate + H(2)O = beta-D-fructose 6-phosphate + NH(4)(+)." [EC:3.5.99.6, RHEA:12175]


id: GO:0004343
name: glucosamine 6-phosphate N-acetyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: D-glucosamine 6-phosphate + acetyl-CoA = N-acetyl-D-glucosamine 6-phosphate + CoA + H(+)." [EC:2.3.1.4, RHEA:10295]


id: GO:0004344
name: glucose dehydrogenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: D-glucose + acceptor = D-glucono-1,5-lactone + reduced acceptor." [EC:1.1.99.10]


id: GO:0004345
name: glucose-6-phosphate dehydrogenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: D-glucose 6-phosphate + NADP+ = D-glucono-1,5-lactone 6-phosphate + NADPH + H+." [EC:1.1.1.49]


id: GO:0004346
name: glucose-6-phosphatase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: D-glucopyranose 6-phosphate + H2O = D-glucose + phosphate. D-glucopyranose is also known as D-glucose 6-phosphate." [EC:3.1.3.9, RHEA:16692]


id: GO:0004348
name: glucosylceramidase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: D-glucosyl-N-acylsphingosine + H2O = D-glucose + N-acylsphingosine." [EC:3.2.1.45]


id: GO:0004349
name: glutamate 5-kinase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: L-glutamate + ATP = L-glutamyl 5-phosphate + ADP + H(+)." [EC:2.7.2.11, RHEA:14880]


id: GO:0004350
name: glutamate-5-semialdehyde dehydrogenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: L-glutamate 5-semialdehyde + NADP(+) + phosphate = L-glutamyl 5-phosphate + H(+) + NADPH." [EC:1.2.1.41, RHEA:19544]


id: GO:0004352
name: glutamate dehydrogenase (NAD+) activity
namespace: molecular_function
def:
  "Catalysis of the reaction: L-glutamate + H2O + NAD+ = 2-oxoglutarate + NH3 + NADH + H+." [EC:1.4.1.2]


id: GO:0004353
name: glutamate dehydrogenase [NAD(P)+] activity
namespace: molecular_function
def:
  "Catalysis of the reaction: L-glutamate + H2O + NAD(P)+ = 2-oxoglutarate + NH3 + NAD(P)H + H+." [EC:1.4.1.3]


id: GO:0004354
name: glutamate dehydrogenase (NADP+) activity
namespace: molecular_function
def:
  "Catalysis of the reaction: L-glutamate + H2O + NADP+ = 2-oxoglutarate + NH3 + NADPH + H+." [EC:1.4.1.4]


id: GO:0004355
name: glutamate synthase (NADPH) activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 2 L-glutamate + NADP(+) = 2-oxoglutarate + L-glutamine + H(+) + NADPH. This is a two-step reaction: (a) L-glutamate + NH3 = L-glutamine + H2O, (b) L-glutamate + NADP+ + H2O = NH3 + 2-oxoglutarate + NADPH + H+." [EC:1.4.1.13, RHEA:15504]


id: GO:0004356
name: glutamate-ammonia ligase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: L-glutamate + ATP + NH(4)(+) = L-glutamine + ADP + 2 H(+) + phosphate." [EC:6.3.1.2, RHEA:16172]


id: GO:0004357
name: glutamate-cysteine ligase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: L-cysteine + L-glutamate + ATP = L-gamma-glutamyl-L-cysteine + ADP + 2 H(+) + phosphate." [EC:6.3.2.2, RHEA:13288]


id: GO:0004358
name: glutamate N-acetyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: N(2)-acetyl-L-ornithine + L-glutamate = N-acetyl-L-glutamate + L-ornithine." [EC:2.3.1.35, RHEA:15352]


id: GO:0004360
name: glutamine-fructose-6-phosphate transaminase (isomerizing) activity
namespace: molecular_function
def:
  "Catalysis of the reaction: beta-D-fructose 6-phosphate + L-glutamine = D-glucosamine 6-phosphate + L-glutamate." [EC:2.6.1.16, RHEA:13240]


id: GO:0004361
name: glutaryl-CoA dehydrogenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: glutaryl-CoA + acceptor = crotonoyl-CoA + CO2 + reduced acceptor." [EC:1.3.99.7]


id: GO:0004362
name: glutathione-disulfide reductase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 2 glutathione + NADP+ = glutathione disulfide + NADPH + H+." [EC:1.8.1.7, ISBN:0198506732]


id: GO:0004363
name: glutathione synthase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: L-gamma-glutamyl-L-cysteine + ATP + glycine = ADP + glutathione + 2 H(+) + phosphate." [EC:6.3.2.3, RHEA:13560]


id: GO:0004364
name: glutathione transferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: R-X + glutathione = H-X + R-S-glutathione. R may be an aliphatic, aromatic or heterocyclic group; X may be a sulfate, nitrile or halide group." [EC:2.5.1.18]


id: GO:0004365
name: glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
namespace: molecular_function
def:
  "Catalysis of the reaction: D-glyceraldehyde 3-phosphate + phosphate + NAD+ = 3-phospho-D-glyceroyl phosphate + NADH + H+." [EC:1.2.1.12]


id: GO:0004366
name: glycerol-3-phosphate O-acyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: acyl-CoA + sn-glycerol 3-phosphate = CoA + 1-acyl-sn-glycerol 3-phosphate." [EC:2.3.1.15]


id: GO:0004367
name: glycerol-3-phosphate dehydrogenase [NAD+] activity
namespace: molecular_function
def:
  "Catalysis of the reaction: sn-glycerol 3-phosphate + NAD+ = glycerone phosphate + NADH + H+." [EC:1.1.1.8, EC:1.1.1.94]


id: GO:0004368
name: glycerol-3-phosphate dehydrogenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: sn-glycerol 3-phosphate + a quinone = glycerone phosphate + a quinol." [EC:1.1.5.3]


id: GO:0004369
name: glycerol-3-phosphate oxidase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: sn-glycerol 3-phosphate + O(2) = glycerone phosphate + H(2)O(2)." [EC:1.1.3.21, RHEA:18372]


id: GO:0004370
name: glycerol kinase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: ATP + glycerol = sn-glycerol 3-phosphate + ADP + 2 H(+)." [EC:2.7.1.30, RHEA:21647]


id: GO:0004371
name: glycerone kinase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: ATP + glycerone = ADP + glycerone phosphate + 2 H(+)." [EC:2.7.1.29, RHEA:15776]


id: GO:0004372
name: glycine hydroxymethyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine." [EC:2.1.2.1]


id: GO:0004373
name: glycogen (starch) synthase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: UDP-glucose + (1,4)-alpha-D-glucosyl(n) = UDP + (1,4)-alpha-D-glucosyl(n+1)." [EC:2.4.1.11]


id: GO:0004374
name: obsolete glycine cleavage system
namespace: molecular_function
def:
  "OBSOLETE. Catalysis of the reactions: glycine + lipoylprotein = S-aminomethyldihydrolipoylprotein + carbon dioxide (CO2), followed by S-aminomethyldihydrolipoylprotein + (6S)-tetrahydrofolate = dihydrolipoylprotein + (6R)-5,10-methylenetetrahydrofolate + ammonia. Made up of two components, aminomethyltransferase and glycine dehydrogenase (decarboxylating)." [EC:1.4.4.2, EC:2.1.2.10]


id: GO:0004375
name: glycine dehydrogenase (decarboxylating) activity
namespace: molecular_function
def:
  "Catalysis of the reaction: glycine + lipoylprotein = S-aminomethyldihydrolipoylprotein + CO2." [EC:1.4.4.2]


id: GO:0004376
name: glycolipid mannosyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the transfer of an alpha-D-mannosyl residue from GDP-mannose into lipid-linked oligosaccharide, forming an alpha-D-mannosyl-D-mannose linkage." [GOC:ai]


id: GO:0004377
name: GDP-Man:Man3GlcNAc2-PP-Dol alpha-1,2-mannosyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: an alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + 2 GDP-alpha-D-mannose = an alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + 2 GDP + 2 H+. This reaction is the transfer of an alpha-D-mannosyl residue from GDP-mannose into lipid-linked oligosaccharide, forming an alpha-(1->2)-D-mannosyl-D-mannose linkage." [EC:2.4.1.131]


id: GO:0004378
name: GDP-Man:Man1GlcNAc2-PP-Dol alpha-1,3-mannosyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + GDP-alpha-D-mannose = alpha-D-Man-(1->3)-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + GDP + H+. This reaction is the transfer of an alpha-D-mannosyl residue from GDP-mannose into lipid-linked oligosaccharide, forming an alpha-(1->3)-D-mannosyl-D-mannose linkage." [EC:2.4.1.132]


id: GO:0004379
name: glycylpeptide N-tetradecanoyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: tetradecanoyl-CoA + glycyl-peptide = CoA + N-tetradecanoylglycyl-peptide." [EC:2.3.1.97]


id: GO:0004380
name: glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: UDP-N-acetyl-D-galactosamine + glycoprotein-alpha-L-fucosyl-(1,2)-D-galactose = UDP + glycoprotein-N-acetyl-alpha-D-galactosaminyl-(1,3)-(alpha-L-fucosyl-(1,2))-D-galactose." [EC:2.4.1.40]


id: GO:0004381
name: fucosylgalactoside 3-alpha-galactosyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: UDP-galactose + glycoprotein-alpha-L-fucosyl-(1,2)-D-galactose = UDP + glycoprotein-alpha-D-galactosyl-(1,3)-(alpha-L-fucosyl-(1,2))-D-galactose." [EC:2.4.1.37]


id: GO:0004384
name: obsolete membrane-associated guanylate kinase
namespace: molecular_function
def:
  "OBSOLETE. Catalysis of the reaction: ATP + GMP = ADP + GDP, associated with the cell membrane." [EC:2.7.4.8]


id: GO:0004386
name: helicase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:mah, ISBN:0198506732]


id: GO:0004392
name: heme oxygenase (decyclizing) activity
namespace: molecular_function
def:
  "Catalysis of the reaction: heme + 3 donor-H2 + 3 O2 = biliverdin + Fe2+ + CO + 3 acceptor + 3 H2O." [EC:1.14.99.3]


id: GO:0004394
name: heparan sulfate 2-O-sulfotransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + heparan sulfate = adenosine 3',5'-bisphosphate + heparan sulfate 2-O-sulfate; results in 2-O-sulfation of iduronic acid residues in heparan sulfate." [PMID:9153262]


id: GO:0004395
name: hexaprenyldihydroxybenzoate methyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: S-adenosyl-L-methionine + 3-hexaprenyl-4,5-dihydroxybenzoate = S-adenosyl-L-homocysteine + 3-hexaprenyl-4-hydroxy-5-methoxybenzoate." [EC:2.1.1.114]


id: GO:0004400
name: histidinol-phosphate transaminase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: L-histidinol-phosphate + 2-oxoglutarate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate." [EC:2.6.1.9]


id: GO:0004401
name: histidinol-phosphatase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: L-histidinol phosphate + H(2)O = L-histidinol + phosphate." [EC:3.1.3.15, RHEA:14468]


id: GO:0004407
name: histone deacetylase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: histone N6-acetyl-L-lysine + H2O = histone L-lysine + acetate. This reaction represents the removal of an acetyl group from a histone, a class of proteins complexed to DNA in chromatin and chromosomes." [EC:3.5.1.98, PMID:9893272]


id: GO:0004409
name: homoaconitate hydratase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: (-)-homoisocitrate = cis-homoaconitate + H(2)O." [EC:4.2.1.36, RHEA:15488]


id: GO:0004410
name: homocitrate synthase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 2-oxoglutarate + acetyl-CoA + H(2)O = CoA + H(+) + homocitrate." [EC:2.3.3.14, RHEA:12932]


id: GO:0004411
name: homogentisate 1,2-dioxygenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: homogentisate + O(2) = 4-maleylacetoacetate + H(+)." [EC:1.13.11.5, RHEA:15452]


id: GO:0004412
name: homoserine dehydrogenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: L-homoserine + NADP+ = L-aspartate-4-semialdehyde + NADPH + H+." [EC:1.1.1.3]


id: GO:0004413
name: homoserine kinase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: L-homoserine + ATP = O-phospho-L-homoserine + ADP + 2 H(+)." [EC:2.7.1.39, RHEA:13988]


id: GO:0004414
name: homoserine O-acetyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: L-homoserine + acetyl-CoA = O-acetyl-L-homoserine + CoA." [EC:2.3.1.31, RHEA:13704]


id: GO:0004415
name: hyalurononglucosaminidase activity
namespace: molecular_function
def:
  "Catalysis of the random hydrolysis of (1->4) linkages between N-acetyl-beta-D-glucosamine and D-glucuronate residues in hyaluronate." [EC:3.2.1.35]


id: GO:0004416
name: hydroxyacylglutathione hydrolase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: (S)-(2-hydroxyacyl)glutathione + H2O = glutathione + a 2-hydroxy carboxylate." [EC:3.1.2.6]


id: GO:0004417
name: hydroxyethylthiazole kinase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 5-(2-hydroxyethyl)-4-methylthiazole + ATP = 4-methyl-5-(2-phosphoethyl)-thiazole + ADP + 2 H(+)." [EC:2.7.1.50, RHEA:24215]


id: GO:0004418
name: hydroxymethylbilane synthase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: H(2)O + 4 porphobilinogen = hydroxymethylbilane + 4 NH(4)(+)." [EC:2.5.1.61, RHEA:13188]


id: GO:0004419
name: hydroxymethylglutaryl-CoA lyase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: (S)-3-hydroxy-3-methylglutaryl-CoA = acetoacetate + acetyl-CoA." [EC:4.1.3.4, RHEA:24407]


id: GO:0004420
name: hydroxymethylglutaryl-CoA reductase (NADPH) activity
namespace: molecular_function
def:
  "Catalysis of the reaction: (R)-mevalonate + CoA + 2 NADP(+) = (S)-3-hydroxy-3-methylglutaryl-CoA + 2 H(+) + 2 NADPH." [EC:1.1.1.34, RHEA:15992]


id: GO:0004421
name: hydroxymethylglutaryl-CoA synthase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: acetoacetyl-CoA + acetyl-CoA + H(2)O = (S)-3-hydroxy-3-methylglutaryl-CoA + CoA + H(+)." [EC:2.3.3.10, RHEA:10191]


id: GO:0004422
name: hypoxanthine phosphoribosyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: IMP + diphosphate = hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate." [EC:2.4.2.8, GOC:curators]


id: GO:0004423
name: iduronate-2-sulfatase activity
namespace: molecular_function
def:
  "Catalysis of the hydrolysis of the 2-sulfate groups of the L-iduronate 2-sulfate units of dermatan sulfate, heparan sulfate and heparin." [EC:3.1.6.13]


id: GO:0004424
name: imidazoleglycerol-phosphate dehydratase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + H(2)O." [EC:4.2.1.19, RHEA:11043]


id: GO:0004425
name: indole-3-glycerol-phosphate synthase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate = 1-(indol-3-yl)glycerol 3-phosphate + CO2 + H2O." [EC:4.1.1.48]


id: GO:0004428
name: obsolete inositol or phosphatidylinositol kinase activity
namespace: molecular_function
def:
  "OBSOLETE. Catalysis of the phosphorylation of myo-inositol (1,2,3,5/4,6-cyclohexanehexol) or a phosphatidylinositol." [GOC:hb]


id: GO:0004430
name: 1-phosphatidylinositol 4-kinase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol + ATP = 1-phosphatidyl-1D-myo-inositol 4-phosphate + ADP + 2 H(+)." [EC:2.7.1.67, RHEA:19880]


id: GO:0004435
name: phosphatidylinositol phospholipase C activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1,2-diacylglycerol + 1D-myo-inositol 1,4,5-trisphosphate + H(+)." [EC:3.1.4.11, RHEA:23915]


id: GO:0004436
name: phosphatidylinositol diacylglycerol-lyase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol = D-myo-inositol 1,2-cyclic phosphate + diacylglycerol." [EC:4.6.1.13]


id: GO:0004437
name: obsolete inositol or phosphatidylinositol phosphatase activity
namespace: molecular_function
def:
  "OBSOLETE. Catalysis of the removal of a phosphate group from phosphorylated myo-inositol (1,2,3,5/4,6-cyclohexanehexol) or a phosphatidylinositol." [GOC:hb]


id: GO:0004438
name: phosphatidylinositol-3-phosphatase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 3-phosphate + H2O = 1-phosphatidyl-1D-myo-inositol + phosphate." [EC:3.1.3.64]


id: GO:0004439
name: phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1-phosphatidyl-1D-myo-inositol 4-phosphate + phosphate." [EC:3.1.3.36, RHEA:22767]


id: GO:0004441
name: inositol-1,4-bisphosphate 1-phosphatase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 1D-myo-inositol 1,4-bisphosphate + H2O = 1D-myo-inositol 4-phosphate + phosphate." [EC:3.1.3.57, GOC:hb]


id: GO:0004442
name: obsolete inositol-1,4,-bisphosphate 3-phosphatase
namespace: molecular_function
def:
  "OBSOLETE. Catalysis of the reaction: D-myo-inositol 1,3-bisphosphate + H2O = D-myo-inositol 1-monophosphate + phosphate." [EC:3.1.3.65, GOC:go_curators]


id: GO:0004443
name: obsolete inositol-1,4,-bisphosphate 4-phosphatase
namespace: molecular_function
def:
  "OBSOLETE. Catalysis of the reaction: D-myo-inositol 3,4-bisphosphate + H2O = D-myo-inositol 3-monophosphate + phosphate." [EC:3.1.3.66, GOC:go_curators]


id: GO:0004444
name: obsolete inositol-1,4,5-trisphosphate 1-phosphatase
namespace: molecular_function
def:
  "OBSOLETE. The removal of a phosphate group from the carbon-1 position of D-myo-inositol 1,4,5-trisphosphate." [EC:3.1.3.61, GOC:hb]


id: GO:0004445
name: inositol-polyphosphate 5-phosphatase activity
namespace: molecular_function
def:
  "Catalysis of the reactions: D-myo-inositol 1,4,5-trisphosphate + H2O = myo-inositol 1,4-bisphosphate + phosphate, and 1D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O = 1D-myo-inositol 1,3,4-trisphosphate + phosphate." [EC:3.1.3.56]


id: GO:0004446
name: inositol-hexakisphosphate phosphatase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: myo-inositol hexakisphosphate + H2O = myo-inositol pentakisphosphate (mixed isomers) + phosphate." [EC:3.1.3.62]


id: GO:0004448
name: isocitrate dehydrogenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: isocitrate + acceptor = 2-oxoglutarate + CO2 + reduced acceptor." [EC:1.1.1.41, EC:1.1.1.42]


id: GO:0004452
name: isopentenyl-diphosphate delta-isomerase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: isopentenyl diphosphate = dimethylallyl diphosphate." [EC:5.3.3.2, RHEA:23287]


id: GO:0004453
name: juvenile-hormone esterase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: methyl (2E,6E)-(10R,11S)-10,11-epoxy-3,7,11-trimethyltrideca-2,6-dienoate + H2O = (2E,6E)-(10R,11S)-10,11-epoxy-3,7,11-trimethyltrideca-2,6-dienoate + methanol. A carboxylesterase that hydrolyzes the ester linkage of juvenile hormone." [EC:3.1.1.59, EMBL:AF304352]


id: GO:0004455
name: ketol-acid reductoisomerase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: (R)-2,3-dihydroxy-3-methylbutanoate + NADP+ = (S)-2-hydroxy-2-methyl-3-oxobutanoate + NADPH + H+." [EC:1.1.1.86]


id: GO:0004456
name: phosphogluconate dehydratase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 6-phospho-D-gluconate = 2-dehydro-3-deoxy-6-phospho-D-gluconate + H(2)O." [EC:4.2.1.12, RHEA:17280]


id: GO:0004458
name: D-lactate dehydrogenase (cytochrome) activity
namespace: molecular_function
def:
  "Catalysis of the reaction: (R)-lactate + 2 ferricytochrome c = pyruvate + 2 ferrocytochrome c." [EC:1.1.2.4]


id: GO:0004460
name: L-lactate dehydrogenase (cytochrome) activity
namespace: molecular_function
def:
  "Catalysis of the reaction: (S)-lactate + 2 ferricytochrome c = pyruvate + 2 ferrocytochrome c." [EC:1.1.2.3]


id: GO:0004462
name: lactoylglutathione lyase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: (R)-S-lactoylglutathione = glutathione + methylglyoxal." [EC:4.4.1.5, RHEA:19072]


id: GO:0004464
name: leukotriene-C4 synthase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: leukotriene C(4) = glutathione + leukotriene A(4)." [EC:4.4.1.20, RHEA:17620]


id: GO:0004465
name: lipoprotein lipase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: triacylglycerol + H2O = diacylglycerol + a carboxylate, where the triacylglycerol is part of a lipoprotein." [EC:3.1.1.34, GOC:bf]


id: GO:0004467
name: long-chain fatty acid-CoA ligase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: ATP + a long-chain carboxylic acid + CoA = AMP + diphosphate + an acyl-CoA; a long-chain fatty acid is a fatty acid with a chain length between C13 and C22." [CHEBI:15904, EC:6.2.1.3]


id: GO:0004468
name: lysine N-acetyltransferase activity, acting on acetyl phosphate as donor
namespace: molecular_function
def:
  "Catalysis of the reaction: acetyl phosphate + L-lysine = phosphate + N6-acetyl-L-lysine." [EC:2.3.1.32]


id: GO:0004470
name: malic enzyme activity
namespace: molecular_function
def:
  "Catalysis of the oxidative decarboxylation of malate with the concomitant production of pyruvate." [ISBN:0198506732]


id: GO:0004471
name: malate dehydrogenase (decarboxylating) (NAD+) activity
namespace: molecular_function
def:
  "Catalysis of the reaction: (S)-malate + NAD+ = pyruvate + CO2 + NADH + H+." [EC:1.1.1.38, EC:1.1.1.39]


id: GO:0004474
name: malate synthase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: acetyl-CoA + glyoxylate + H(2)O = (S)-malate + CoA + H(+)." [EC:2.3.3.9, RHEA:18184]


id: GO:0004475
name: mannose-1-phosphate guanylyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: alpha-D-mannose 1-phosphate + GTP = diphosphate + GDP-alpha-D-mannose." [EC:2.7.7.13, RHEA:15232]


id: GO:0004477
name: methenyltetrahydrofolate cyclohydrolase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 5,10-methenyltetrahydrofolate + H2O = 10-formyltetrahydrofolate." [EC:3.5.4.9]


id: GO:0004478
name: methionine adenosyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: ATP + L-methionine + H2O = phosphate + diphosphate + S-adenosyl-L-methionine." [EC:2.5.1.6]


id: GO:0004479
name: methionyl-tRNA formyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 10-formyltetrahydrofolate + L-methionyl-tRNA + H2O = tetrahydrofolate + N-formylmethionyl-tRNA." [EC:2.1.2.9]


id: GO:0004481
name: methylene-fatty-acyl-phospholipid synthase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: S-adenosyl-L-methionine + phospholipid olefinic fatty acid = S-adenosyl-L-homocysteine + phospholipid methylene fatty acid." [EC:2.1.1.16]


id: GO:0004482
name: mRNA (guanine-N7-)-methyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: S-adenosyl-L-methionine + G(5')pppR-RNA = S-adenosyl-L-homocysteine + m7G(5')pppR-RNA. m7G(5')pppR-RNA is mRNA containing an N7-methylguanine cap; R may be guanosine or adenosine." [EC:2.1.1.56]


id: GO:0004483
name: mRNA (nucleoside-2'-O-)-methyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: S-adenosyl-L-methionine + m7G(5')pppR-RNA = S-adenosyl-L-homocysteine + m7G(5')pppRm-RNA. R may be guanosine or adenosine." [EC:2.1.1.57]


id: GO:0004484
name: mRNA guanylyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: GTP + (5')pp-Pur-mRNA = diphosphate + G(5')ppp-Pur-mRNA; G(5')ppp-Pur-mRNA is mRNA containing a guanosine residue linked 5' through three phosphates to the 5' position of the terminal residue." [EC:2.7.7.50]


id: GO:0004485
name: methylcrotonoyl-CoA carboxylase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 3-methylbut-2-enoyl-CoA + ATP + bicarbonate = trans-3-methylglutaconyl-CoA + ADP + 2 H(+) + phosphate." [EC:6.4.1.4, RHEA:13592]


id: GO:0004486
name: methylenetetrahydrofolate dehydrogenase [NAD(P)+] activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 5,10-methylenetetrahydrofolate + NAD(P)+ = 5,10-methenyltetrahydrofolate + NAD(P)H + H+." [EC:1.5.1.-, EC:1.5.1.15]


id: GO:0004487
name: methylenetetrahydrofolate dehydrogenase (NAD+) activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 5,10-methylenetetrahydrofolate + NAD(+) = 5,10-methenyltetrahydrofolate + NADH." [EC:1.5.1.15, RHEA:22895]


id: GO:0004488
name: methylenetetrahydrofolate dehydrogenase (NADP+) activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 5,10-methylenetetrahydrofolate + NADP(+) = 5,10-methenyltetrahydrofolate + NADPH." [EC:1.5.1.5, RHEA:22815]


id: GO:0004489
name: methylenetetrahydrofolate reductase (NAD(P)H) activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 5-methyltetrahydrofolate + NAD(P)+ = 5,10-methylenetetrahydrofolate + NAD(P)H + H+." [EC:1.5.1.20]


id: GO:0004490
name: methylglutaconyl-CoA hydratase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: (S)-3-hydroxy-3-methylglutaryl-CoA = trans-3-methylglutaconyl-CoA + H(2)O." [EC:4.2.1.18, RHEA:21539]


id: GO:0004491
name: methylmalonate-semialdehyde dehydrogenase (acylating) activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 2-methyl-3-oxopropanoate + CoA + NAD+ = propanoyl-CoA + CO2 + NADH + H+." [EC:1.2.1.27]


id: GO:0004493
name: methylmalonyl-CoA epimerase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: (R)-methylmalonyl-CoA = (S)-methylmalonyl-CoA." [EC:5.1.99.1, RHEA:20556]


id: GO:0004495
name: mevaldate reductase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: (R)-mevalonate + acceptor = mevaldate + reduced acceptor." [EC:1.1.1.32, EC:1.1.1.33]


id: GO:0004496
name: mevalonate kinase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: (R)-mevalonate + ATP = (R)-5-phosphomevalonate + ADP + 2 H(+)." [EC:2.7.1.36, RHEA:17068]


id: GO:0004497
name: monooxygenase activity
namespace: molecular_function
def:
  "Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water." [http://www.onelook.com/, ISBN:0198506732]


id: GO:0004498
name: calcidiol 1-monooxygenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: calcidiol + H(+) + NADPH + O(2) = calcitriol + H(2)O + NADP(+)." [EC:1.14.13.13, RHEA:20576]


id: GO:0004499
name: N,N-dimethylaniline monooxygenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: N,N-dimethylaniline + NADPH + H+ + O2 = N,N-dimethylaniline N-oxide + NADP+ + H2O." [EC:1.14.13.8]


id: GO:0004500
name: dopamine beta-monooxygenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: L-ascorbate + dopamine + O(2) = (R)-noradrenaline + dehydroascorbate + H(2)O." [EC:1.14.17.1, RHEA:19120]


id: GO:0004501
name: ecdysone 20-monooxygenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: AH(2) + Ecdysone + O(2) = 20-hydroxyecdysone + A + H(2)O." [EC:1.14.99.22, RHEA:14024]


id: GO:0004502
name: kynurenine 3-monooxygenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: L-kynurenine + H(+) + NADPH + O(2) = 3-hydroxy-L-kynurenine + H(2)O + NADP(+)." [EC:1.14.13.9, RHEA:20548]


id: GO:0004503
name: monophenol monooxygenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: L-tyrosine + L-DOPA + O2 = L-DOPA + DOPAquinone + H2O." [EC:1.14.18.1, GOC:bf, GOC:sart, PMID:4965136]


id: GO:0004504
name: peptidylglycine monooxygenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: peptidyl-glycine + ascorbate + O2 = peptidyl(2-hydroxyglycine) + dehydroascorbate + H2O." [EC:1.14.17.3]


id: GO:0004505
name: phenylalanine 4-monooxygenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: L-phenylalanine + tetrahydrobiopterin + O2 = L-tyrosine + 4-alpha-hydroxytetrahydrobiopterin." [EC:1.14.16.1]


id: GO:0004506
name: squalene monooxygenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: H(+) + NADPH + O(2) + squalene = (S)-2,3-epoxysqualene + H(2)O + NADP(+)." [RHEA:25285]


id: GO:0004507
name: steroid 11-beta-monooxygenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: a steroid + reduced adrenal ferredoxin + O2 = an 11-beta-hydroxysteroid + oxidized adrenal ferredoxin + H2O." [EC:1.14.15.4]


id: GO:0004509
name: steroid 21-monooxygenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: a steroid + donor-H2 + O2 = a 21-hydroxysteroid + acceptor + H2O." [EC:1.14.99.10]


id: GO:0004510
name: tryptophan 5-monooxygenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: L-tryptophan + tetrahydrobiopterin + O2 = 5-hydroxy-L-tryptophan + 4-alpha-hydroxytetrahydrobiopterin + H2O." [EC:1.14.16.4]


id: GO:0004511
name: tyrosine 3-monooxygenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: L-tyrosine + tetrahydrobiopterin + O2 = 3,4-dihydroxy-L-phenylalanine + 4-alpha-hydroxytetrahydrobiopterin + H2O." [EC:1.14.16.2]


id: GO:0004512
name: inositol-3-phosphate synthase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: D-glucose 6-phosphate = 1D-myo-inositol 3-phosphate. This reaction requires NAD, which dehydrogenates the CHOH group to CO at C-5 of the glucose 6-phosphate, making C-6 into an active methylene, able to condense with the aldehyde at C-1. Finally, the enzyme-bound NADH reconverts C-5 into the CHOH form." [EC:5.5.1.4, RHEA:10719]


id: GO:0004513
name: neolactotetraosylceramide alpha-2,3-sialyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide = CMP + alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-D-glucosylceramide." [EC:2.4.99.10]


id: GO:0004514
name: nicotinate-nucleotide diphosphorylase (carboxylating) activity
namespace: molecular_function
def:
  "Catalysis of the reaction: CO(2) + diphosphate + nicotinate D-ribonucleotide = 5-phospho-alpha-D-ribose 1-diphosphate + 2 H(+) + quinolinate." [EC:2.4.2.19, RHEA:12736]


id: GO:0004515
name: nicotinate-nucleotide adenylyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: ATP + nicotinate ribonucleotide = diphosphate + deamido-NAD+." [EC:2.7.7.18]


id: GO:0004516
name: nicotinate phosphoribosyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: diphosphate + nicotinate D-ribonucleotide = 5-phospho-alpha-D-ribose 1-diphosphate + H(+) + nicotinate." [EC:2.4.2.11, RHEA:13396]


id: GO:0004517
name: nitric-oxide synthase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: L-arginine + n NADPH + n H+ + m O2 = citrulline + nitric oxide + n NADP+." [EC:1.14.13.39]


id: GO:0004519
name: endonuclease activity
namespace: molecular_function
def:
  "Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks." [GOC:mah, ISBN:0198547684]


id: GO:0004520
name: endodeoxyribonuclease activity
namespace: molecular_function
def:
  "Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acid by creating internal breaks." [GOC:mah, ISBN:0198547684]


id: GO:0004521
name: endoribonuclease activity
namespace: molecular_function
def:
  "Catalysis of the hydrolysis of ester linkages within ribonucleic acid by creating internal breaks." [GOC:mah, ISBN:0198547684]


id: GO:0004522
name: ribonuclease A activity
namespace: molecular_function
def:
  "Catalysis of the endonucleolytic cleavage of RNA to 3'-phosphomononucleotides and 3'-phosphooligonucleotides ending in C-P or U-P with 2',3'-cyclic phosphate intermediates." [EC:3.1.27.5]


id: GO:0004523
name: RNA-DNA hybrid ribonuclease activity
namespace: molecular_function
def:
  "Catalysis of the endonucleolytic cleavage of RNA in RNA-DNA hybrids to 5'-phosphomonoesters." [EC:3.1.26.4]


id: GO:0004525
name: ribonuclease III activity
namespace: molecular_function
def:
  "Catalysis of the endonucleolytic cleavage of RNA with 5'-phosphomonoesters and 3'-OH termini; makes two staggered cuts in both strands of dsRNA, leaving a 3' overhang of 2 nt." [PMID:11157775, PMID:15242644]


id: GO:0004526
name: ribonuclease P activity
namespace: molecular_function
def:
  "Catalysis of the endonucleolytic cleavage of RNA, removing 5' extra nucleotides from tRNA precursor." [EC:3.1.26.5]


id: GO:0004527
name: exonuclease activity
namespace: molecular_function
def:
  "Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' or 5' end." [GOC:mah, ISBN:0198547684]


id: GO:0004528
name: phosphodiesterase I activity
namespace: molecular_function
def:
  "Catalysis of the sequential hydrolytic removal of 5'-nucleotides from the 3'-hydroxy termini of 3'-hydroxy-terminated oligonucleotides." [EC:3.1.4.1]


id: GO:0004529
name: exodeoxyribonuclease activity
namespace: molecular_function
def:
  "Catalysis of the sequential cleavage of mononucleotides from a free 5' or 3' terminus of a DNA molecule." [GOC:mah, ISBN:0198547684]


id: GO:0004530
name: deoxyribonuclease I activity
namespace: molecular_function
def:
  "Catalysis of the endonucleolytic cleavage of DNA to 5'-phosphodinucleotide and 5'-phosphooligonucleotide end products." [EC:3.1.21.1]


id: GO:0004531
name: deoxyribonuclease II activity
namespace: molecular_function
def:
  "Catalysis of the endonucleolytic cleavage of DNA to 3'-phosphodinucleotide and 3'-phosphooligonucleotide end products." [EC:3.1.22.1]


id: GO:0004532
name: exoribonuclease activity
namespace: molecular_function
def:
  "Catalysis of the sequential cleavage of mononucleotides from a free 5' or 3' terminus of an RNA molecule." [GOC:mah, ISBN:0198547684]


id: GO:0004533
name: exoribonuclease H activity
namespace: molecular_function
def:
  "Catalysis of the exonucleolytic cleavage of RNA to 5'-phosphomonoester oligonucleotides in both 5' to 3' and 3' to 5' directions." [EC:3.1.13.2, ISBN:0198547684]


id: GO:0004534
name: 5'-3' exoribonuclease activity
namespace: molecular_function
def:
  "Catalysis of the sequential cleavage of mononucleotides from a free 5' terminus of an RNA molecule." [GOC:mah, ISBN:0198547684]


id: GO:0004536
name: deoxyribonuclease activity
namespace: molecular_function
def:
  "Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acid." [GOC:mah, ISBN:0198547684]


id: GO:0004550
name: nucleoside diphosphate kinase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: ATP + nucleoside diphosphate = ADP + nucleoside triphosphate." [EC:2.7.4.6]


id: GO:0004552
name: octanol dehydrogenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 1-octanol + NAD(+) = 1-octanal + H(+) + NADH." [EC:1.1.1.73, RHEA:24623]


id: GO:0004556
name: alpha-amylase activity
namespace: molecular_function
def:
  "Catalysis of the endohydrolysis of (1->4)-alpha-D-glucosidic linkages in polysaccharides containing three or more alpha-(1->4)-linked D-glucose units." [EC:3.2.1.1]


id: GO:0004557
name: alpha-galactosidase activity
namespace: molecular_function
def:
  "Catalysis of the hydrolysis of terminal, non-reducing alpha-D-galactose residues in alpha-D-galactosides, including galactose oligosaccharides, galactomannans and galactohydrolase." [EC:3.2.1.22]


id: GO:0004558
name: alpha-1,4-glucosidase activity
namespace: molecular_function
def:
  "Catalysis of the hydrolysis of terminal, non-reducing alpha-(1->4)-linked alpha-D-glucose residues with release of alpha-D-glucose." [EC:3.2.1.20]


id: GO:0004559
name: alpha-mannosidase activity
namespace: molecular_function
def:
  "Catalysis of the hydrolysis of terminal, non-reducing alpha-D-mannose residues in alpha-D-mannosides." [EC:3.2.1.24]


id: GO:0004561
name: alpha-N-acetylglucosaminidase activity
namespace: molecular_function
def:
  "Catalysis of the hydrolysis of terminal non-reducing N-acetyl-D-glucosamine residues in N-acetyl-alpha-D-glucosaminides." [EC:3.2.1.50]


id: GO:0004563
name: beta-N-acetylhexosaminidase activity
namespace: molecular_function
def:
  "Catalysis of the hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides." [EC:3.2.1.52]


id: GO:0004564
name: beta-fructofuranosidase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: a fructofuranosylated fructofuranosyl acceptor + H2O = a non fructofuranosylated fructofuranosyl acceptor + a beta-D-fructofuranoside." [EC:3.2.1.26, MetaCyc:RXN-9985]


id: GO:0004565
name: beta-galactosidase activity
namespace: molecular_function
def:
  "Catalysis of the hydrolysis of terminal, non-reducing beta-D-galactose residues in beta-D-galactosides." [EC:3.2.1.23]


id: GO:0004566
name: beta-glucuronidase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: a beta-D-glucuronoside + H2O = an alcohol + D-glucuronate." [EC:3.2.1.31]


id: GO:0004567
name: beta-mannosidase activity
namespace: molecular_function
def:
  "Catalysis of the hydrolysis of terminal, non-reducing beta-D-mannose residues in beta-D-mannosides." [EC:3.2.1.25]


id: GO:0004568
name: chitinase activity
namespace: molecular_function
def:
  "Catalysis of the hydrolysis of (1->4)-beta linkages of N-acetyl-D-glucosamine (GlcNAc) polymers of chitin and chitodextrins." [EC:3.2.1.14, GOC:bf, GOC:kah, GOC:pde, PMID:11468293]


id: GO:0004569
name: glycoprotein endo-alpha-1,2-mannosidase activity
namespace: molecular_function
def:
  "Catalysis of the hydrolysis of the terminal alpha-glucosyl-(1,3)-mannosyl unit from Glc-Man(9)-(GlcNAc)(2) oligosaccharide component of the glycoprotein produced in the Golgi membrane." [EC:3.2.1.130]


id: GO:0004571
name: mannosyl-oligosaccharide 1,2-alpha-mannosidase activity
namespace: molecular_function
def:
  "Catalysis of the hydrolysis of the terminal (1->2)-linked alpha-D-mannose residues in an oligo-mannose oligosaccharide." [GOC:bf, PMID:25092655]


id: GO:0004572
name: mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity
namespace: molecular_function
def:
  "Catalysis of the hydrolysis of the terminal (1->3)- and (1->6)-linked alpha-D-mannose residues in the mannosyl-oligosaccharide Man(5)(GlcNAc)(3)." [EC:3.2.1.114]


id: GO:0004573
name: mannosyl-oligosaccharide glucosidase activity
namespace: molecular_function
def:
  "Catalysis of the exohydrolysis of the non-reducing terminal glucose residue in the mannosyl-oligosaccharide Glc(3)Man(9)GlcNAc(2)." [EC:3.2.1.106]


id: GO:0004574
name: oligo-1,6-glucosidase activity
namespace: molecular_function
def:
  "Catalysis of the hydrolysis of (1->6)-alpha-D-glucosidic linkages in some oligosaccharides produced from starch and glycogen by alpha-amylase, and in isomaltose. Releases a free alpha-D-glucose." [EC:3.2.1.10]


id: GO:0004575
name: sucrose alpha-glucosidase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: sucrose + H2O = alpha-D-glucose + beta-D-fructose." [EC:3.2.1.48, MetaCyc:RXN-1461]


id: GO:0004576
name: oligosaccharyl transferase activity
namespace: molecular_function
def:
  "Catalysis of the transfer of a oligosaccharyl group to an acceptor molecule, typically another carbohydrate or a lipid." [GOC:ai]


id: GO:0004577
name: N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + N-acetyl-D-glucosaminyl-diphosphodolichol = UDP + N,N''-diacetylchitobiosyldiphosphodolichol." [EC:2.4.1.141]


id: GO:0004578
name: chitobiosyldiphosphodolichol beta-mannosyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: GDP-mannose + chitobiosyldiphosphodolichol = GDP + beta-D-mannosylchitobiosyldiphosphodolichol." [EC:2.4.1.142]


id: GO:0004579
name: dolichyl-diphosphooligosaccharide-protein glycotransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: dolichyl diphosphooligosaccharide + protein L-asparagine = dolichyl diphosphate + a glycoprotein with the oligosaccharide chain attached by glycosylamine linkage to protein L-asparagine." [EC:2.4.1.119]


id: GO:0004581
name: dolichyl-phosphate beta-glucosyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: UDP-glucose + dolichyl phosphate = UDP + dolichyl beta-D-glucosyl phosphate." [EC:2.4.1.117]


id: GO:0004582
name: dolichyl-phosphate beta-D-mannosyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: GDP-mannose + dolichyl phosphate = GDP + dolichyl D-mannosyl phosphate." [EC:2.4.1.83]


id: GO:0004583
name: dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the transfer of an alpha-D-glucosyl residue from dolichyl-phosphate D-glucose into a membrane lipid-linked oligosaccharide." [GOC:mah]


id: GO:0004584
name: dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the transfer of an alpha-D-mannosyl residue from dolichyl-phosphate D-mannose into membrane lipid-linked oligosaccharide." [EC:2.4.1.130]


id: GO:0004585
name: ornithine carbamoyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: carbamoyl phosphate + L-ornithine = phosphate + L-citrulline." [EC:2.1.3.3]


id: GO:0004587
name: ornithine-oxo-acid transaminase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: L-ornithine + a 2-oxo acid = L-glutamate 5-semialdehyde + an L-amino acid." [EC:2.6.1.13]


id: GO:0004588
name: orotate phosphoribosyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: orotidine 5'-phosphate + diphosphate = orotate + 5-phospho-alpha-D-ribose 1-diphosphate." [EC:2.4.2.10]


id: GO:0004589
name: orotate reductase (NADH) activity
namespace: molecular_function
def:
  "Catalysis of the reaction: (S)-dihydroorotate + NAD(+) = H(+) + NADH + orotate." [EC:1.3.1.14, RHEA:13516]


id: GO:0004591
name: oxoglutarate dehydrogenase (succinyl-transferring) activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 2-oxoglutarate + lipoamide = S-succinyldihydrolipoamide + CO2." [EC:1.2.4.2]


id: GO:0004592
name: pantoate-beta-alanine ligase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: ATP + (R)-pantoate + beta-alanine = AMP + diphosphate + (R)-pantothenate." [EC:6.3.2.1]


id: GO:0004593
name: pantothenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: (R)-pantothenate + H(2)O = (R)-pantoate + beta-alanine." [EC:3.5.1.22, RHEA:12451]


id: GO:0004595
name: pantetheine-phosphate adenylyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: ATP + pantetheine 4'-phosphate = 3'-dephospho-CoA + diphosphate." [EC:2.7.7.3, RHEA:19804]


id: GO:0004596
name: peptide alpha-N-acetyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: acetyl-CoA + peptide = CoA + N-alpha-acetylpeptide. This reaction is the acetylation of the N-terminal amino acid residue of a peptide or protein." [EC:2.3.1.88, GOC:mah]


id: GO:0004597
name: peptide-aspartate beta-dioxygenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: peptide L-aspartate + 2-oxoglutarate + O2 = peptide 3-hydroxy-L-aspartate + succinate + CO2." [EC:1.14.11.16]


id: GO:0004600
name: obsolete cyclophilin
namespace: molecular_function
def:
  "OBSOLETE. A protein to which cyclosporin A (an immunosuppressant) binds. Possesses peptidyl-prolyl isomerase activity." [EC:5.2.1.8, ISBN:0198506732]


id: GO:0004602
name: glutathione peroxidase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 2 glutathione + hydrogen peroxide = oxidized glutathione + 2 H2O." [EC:1.11.1.9]


id: GO:0004603
name: phenylethanolamine N-methyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: S-adenosyl-L-methionine + phenylethanolamine = S-adenosyl-L-homocysteine + N-methylphenylethanolamine." [EC:2.1.1.28]


id: GO:0004604
name: phosphoadenylyl-sulfate reductase (thioredoxin) activity
namespace: molecular_function
def:
  "Catalysis of the reaction: adenosine 3',5'-diphosphate + H(+) + sulfite + thioredoxin disulfide = 3'-phospho-5'-adenylyl sulfate + thioredoxin. Thioredoxin disulfide is the oxidized form of thioredoxin; 3'-phosphoadenosine 5'-phosphosulfate is also known as PAPS." [EC:1.8.4.8, RHEA:11727]


id: GO:0004607
name: phosphatidylcholine-sterol O-acyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: phosphatidylcholine + a sterol = a sterol ester + 1-acylglycerophosphocholine." [EC:2.3.1.43]


id: GO:0004608
name: phosphatidylethanolamine N-methyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: S-adenosyl-L-methionine + phosphatidylethanolamine = S-adenosyl-L-homocysteine + H(+) + phosphatidyl-N-methylethanolamine." [EC:2.1.1.17, RHEA:11167]


id: GO:0004609
name: phosphatidylserine decarboxylase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: H(+) + phosphatidyl-L-serine = CO(2) + phosphatidylethanolamine." [EC:4.1.1.65, RHEA:20831]


id: GO:0004610
name: phosphoacetylglucosamine mutase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: N-acetyl-alpha-D-glucosamine 1-phosphate = N-acetyl-D-glucosamine 6-phosphate." [EC:5.4.2.3, RHEA:23807]


id: GO:0004611
name: phosphoenolpyruvate carboxykinase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: source of phosphate + oxaloacetate = phosphoenolpyruvate + CO2 + other reaction products." [EC:4.1.1.-]


id: GO:0004612
name: phosphoenolpyruvate carboxykinase (ATP) activity
namespace: molecular_function
def:
  "Catalysis of the reaction: ATP + oxaloacetate = ADP + CO(2) + H(+) + phosphoenolpyruvate." [EC:4.1.1.49, RHEA:18620]


id: GO:0004614
name: phosphoglucomutase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: alpha-D-glucose 1-phosphate = alpha-D-glucose 6-phosphate." [EC:5.4.2.2]


id: GO:0004615
name: phosphomannomutase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: alpha-D-mannose 1-phosphate = D-mannose 6-phosphate." [EC:5.4.2.8, RHEA:11143]


id: GO:0004616
name: phosphogluconate dehydrogenase (decarboxylating) activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH + H+." [EC:1.1.1.44]


id: GO:0004617
name: phosphoglycerate dehydrogenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 3-phosphoglycerate + NAD+ = 3-phosphohydroxypyruvate + NADH + H+." [EC:1.1.1.95]


id: GO:0004618
name: phosphoglycerate kinase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 3-phospho-D-glycerate + ATP = 3-phospho-D-glyceroyl phosphate + ADP + H(+)." [EC:2.7.2.3, RHEA:14804]


id: GO:0004621
name: glycosylphosphatidylinositol phospholipase D activity
namespace: molecular_function
def:
  "Catalysis of the reaction: glycoprotein phosphatidylinositol + H2O = phosphatidate + glycoprotein inositol." [EC:3.1.4.50]


id: GO:0004622
name: lysophospholipase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate." [EC:3.1.1.5]


id: GO:0004623
name: phospholipase A2 activity
namespace: molecular_function
def:
  "Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate." [EC:3.1.1.4]


id: GO:0004624
name: obsolete secreted phospholipase A2 activity
namespace: molecular_function
def:
  "OBSOLETE. Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a fatty acid anion." [EC:3.1.1.4]


id: GO:0004629
name: phospholipase C activity
namespace: molecular_function
def:
  "Catalysis of the reaction: a phospholipid + H2O = 1,2-diacylglycerol + a phosphatidate." [EC:3.1.4.3, EC:3.1.4.4, GOC:mah]


id: GO:0004631
name: phosphomevalonate kinase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: (R)-5-phosphomevalonate + ATP = (R)-5-diphosphomevalonate + ADP + H(+)." [EC:2.7.4.2, RHEA:16344]


id: GO:0004632
name: phosphopantothenate--cysteine ligase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: CTP + (R)-4'-phosphopantothenate + L-cysteine = CMP + diphosphate + (R)-4'-phosphopantothenoyl-L-cysteine. Cysteine can be replaced by some of its derivatives." [EC:6.3.2.5]


id: GO:0004633
name: phosphopantothenoylcysteine decarboxylase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: N-[(R)-4-phosphonatopantothenoyl]-L-cysteinate + H(+) = CO(2) + pantetheine 4'-phosphate." [EC:4.1.1.36, RHEA:16796]


id: GO:0004634
name: phosphopyruvate hydratase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 2-phospho-D-glycerate = phosphoenolpyruvate + H2O." [EC:4.2.1.11, ISBN:0198506732]


id: GO:0004635
name: phosphoribosyl-AMP cyclohydrolase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 1-(5-phosphonatoribosyl)-5'-AMP + H(2)O = 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide." [EC:3.5.4.19, RHEA:20052]


id: GO:0004636
name: phosphoribosyl-ATP diphosphatase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 1-(5-phospho-D-ribosyl)-ATP + H(2)O = 1-(5-phosphonatoribosyl)-5'-AMP + diphosphate + H(+)." [EC:3.6.1.31, RHEA:22831]


id: GO:0004637
name: phosphoribosylamine-glycine ligase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 5-phospho-D-ribosylamine + ATP + glycine = N(1)-(5-phospho-D-ribosyl)glycinamide + ADP + 2 H(+) + phosphate." [EC:6.3.4.13, RHEA:17456]


id: GO:0004638
name: phosphoribosylaminoimidazole carboxylase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + 2 H(+) = 5-amino-1-(5-phospho-D-ribosyl)imidazole + CO(2)." [EC:4.1.1.21, RHEA:10795]


id: GO:0004639
name: phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-aspartate + ATP = (2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate + ADP + 2 H(+) + phosphate." [EC:6.3.2.6, RHEA:22631]


id: GO:0004640
name: phosphoribosylanthranilate isomerase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: N-(5-phospho-beta-D-ribosyl)anthranilate = 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate." [EC:5.3.1.24, RHEA:21543]


id: GO:0004641
name: phosphoribosylformylglycinamidine cyclo-ligase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine + ATP = 5-amino-1-(5-phospho-D-ribosyl)imidazole + ADP + 2 H(+) + phosphate." [EC:6.3.3.1, RHEA:23035]


id: GO:0004642
name: phosphoribosylformylglycinamidine synthase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide + L-glutamine + ATP + H(2)O = 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine + L-glutamate + ADP + 2 H(+) + phosphate." [EC:6.3.5.3, RHEA:17132]


id: GO:0004643
name: phosphoribosylaminoimidazolecarboxamide formyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 10-formyltetrahydrofolate + 5'-phosphoribosyl-5-amino-4-imidazolecarboxamide = tetrahydrofolate + 5'-phosphoribosyl-5-formamido-4-imidazolecarboxamide." [EC:2.1.2.3]


id: GO:0004644
name: phosphoribosylglycinamide formyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 10-formyltetrahydrofolate + N1-(5-phospho-D-ribosyl)glycinamide = tetrahydrofolate + N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide." [EC:2.1.2.2]


id: GO:0004645
name: phosphorylase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 1,4-alpha-D-glucosyl(n) + phosphate = 1,4-alpha-D-glucosyl(n-1) + alpha-D-glucose 1-phosphate. The name should be qualified in each instance by adding the name of the natural substrate, e.g. maltodextrin phosphorylase, starch phosphorylase, glycogen phosphorylase." [EC:2.4.1.1]


id: GO:0004647
name: phosphoserine phosphatase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: L(or D)-O-phosphoserine + H2O = L(or D)-serine + phosphate." [EC:3.1.3.3]


id: GO:0004648
name: O-phospho-L-serine:2-oxoglutarate aminotransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: O-phospho-L-serine + 2-oxoglutarate = 3-phosphonooxypyruvate + L-glutamate." [EC:2.6.1.52]


id: GO:0004649
name: poly(ADP-ribose) glycohydrolase activity
namespace: molecular_function
def:
  "Catalysis of the hydrolysis of poly(ADP-ribose) at glycosidic (1''-2') linkage of ribose-ribose bond to produce free ADP-ribose." [EC:3.2.1.143]


id: GO:0004650
name: polygalacturonase activity
namespace: molecular_function
def:
  "Catalysis of the random hydrolysis of (1->4)-alpha-D-galactosiduronic linkages in pectate and other galacturonans." [EC:3.2.1.15]


id: GO:0004651
name: polynucleotide 5'-phosphatase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 5'-phosphopolynucleotide + H2O = polynucleotide + phosphate." [EC:3.1.3.33]


id: GO:0004652
name: polynucleotide adenylyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the template-independent extension of the 3'- end of an RNA or DNA strand by addition of one adenosine molecule at a time. Cannot initiate a chain 'de novo'. The primer, depending on the source of the enzyme, may be an RNA or DNA fragment, or oligo(A) bearing a 3'-OH terminal group." [EC:2.7.7.19]


id: GO:0004653
name: polypeptide N-acetylgalactosaminyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: UDP-N-acetyl-D-galactosamine + polypeptide = UDP + N-acetyl-D-galactosaminyl-polypeptide. This reaction is the modification of serine or threonine residues in polypeptide chains by the transfer of a N-acetylgalactose from UDP-N-acetylgalactose to the hydroxyl group of the amino acid; it is the first step in O-glycan biosynthesis." [EC:2.4.1.41, ISBN:0879695595]


id: GO:0004655
name: porphobilinogen synthase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 2 5-aminolevulinate = 2 H(2)O + H(+) + porphobilinogen." [EC:4.2.1.24, RHEA:24067]


id: GO:0004656
name: procollagen-proline 4-dioxygenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: procollagen L-proline + 2-oxoglutarate + O2 = procollagen trans-4-hydroxy-L-proline + succinate + CO2." [EC:1.14.11.2]


id: GO:0004657
name: proline dehydrogenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: L-proline + acceptor = (S)-1-pyrroline-5-carboxylate + reduced acceptor." [EC:1.5.99.8]


id: GO:0004658
name: propionyl-CoA carboxylase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: ATP + propanoyl-CoA + HCO3- = ADP + phosphate + (S)-methylmalonyl-CoA." [EC:6.4.1.3]


id: GO:0004659
name: prenyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the transfer of a prenyl group from one compound (donor) to another (acceptor)." [GOC:mah]


id: GO:0004660
name: protein farnesyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: farnesyl diphosphate + protein-cysteine = S-farnesyl protein + diphosphate." [EC:2.5.1.58, PMID:8621375]


id: GO:0004661
name: protein geranylgeranyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the covalent addition of a geranylgeranyl (20-carbon isoprenoid) group via thioether linkages to a cysteine residue at or near the C terminus of a protein." [PMID:8621375]


id: GO:0004662
name: CAAX-protein geranylgeranyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: geranylgeranyl diphosphate + protein-cysteine = S-geranylgeranyl-protein + diphosphate. This reaction is the formation of a thioether linkage between the C-1 atom of the geranylgeranyl group and a cysteine residue fourth from the C-terminus of the protein. The protein substrates have the C-terminal sequence CA1A2X, where the terminal residue, X, is preferably leucine and A2 should not be aromatic. Known substrates include most g-subunits of heterotrimeric G proteins and Ras-related GTPases such as members of the Ras and Rac/Rho families." [EC:2.5.1.59, PMID:8621375]


id: GO:0004663
name: Rab geranylgeranyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 2 geranylgeranyl diphosphate + protein-cysteine = 2 S-geranylgeranyl-protein + 2 diphosphate. This reaction is the formation of two thioether linkages between the C-1 atom of the geranylgeranyl groups and two cysteine residues within the terminal sequence motifs XXCC, XCXC or CCXX. Known substrates include Ras-related GTPases of a single family and the Rab family." [EC:2.5.1.60, GOC:mah, PMID:8621375]


id: GO:0004665
name: prephenate dehydrogenase (NADP+) activity
namespace: molecular_function
def:
  "Catalysis of the reaction: NADP(+) + prephenate = (4-hydroxyphenyl)pyruvate + CO(2) + NADPH." [EC:1.3.1.13, RHEA:21643]


id: GO:0004666
name: prostaglandin-endoperoxide synthase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: arachidonate + donor-H2 + 2 O2 = prostaglandin H2 + acceptor + H2O." [EC:1.14.99.1]


id: GO:0004671
name: protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: S-adenosyl-L-methionine + protein C-terminal S-farnesyl-L-cysteine = S-adenosyl-L-homocysteine + protein C-terminal S-farnesyl-L-cysteine methyl ester." [EC:2.1.1.100]


id: GO:0004672
name: protein kinase activity
namespace: molecular_function
def:
  "Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN]


id: GO:0004673
name: protein histidine kinase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: ATP + protein L-histidine = ADP + protein phospho-L-histidine." [EC:2.7.13.3, GOC:mah]


id: GO:0004674
name: protein serine/threonine kinase activity
namespace: molecular_function
def:
  "Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf]


id: GO:0004675
name: transmembrane receptor protein serine/threonine kinase activity
namespace: molecular_function
def:
  "Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [EC:2.7.11.30]


id: GO:0004676
name: 3-phosphoinositide-dependent protein kinase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires the presence of a phosphatidylinositol-3-phosphate." [GOC:mah]


id: GO:0004677
name: DNA-dependent protein kinase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires the presence of DNA." [GOC:mah]


id: GO:0004679
name: AMP-activated protein kinase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires the presence of AMP." [GOC:mah]


id: GO:0004683
name: calmodulin-dependent protein kinase activity
namespace: molecular_function
def:
  "Catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; and ATP + a protein threonine = ADP + protein threonine phosphate. These reactions require the presence of calcium-bound calmodulin." [GOC:mah, PMID:11264466]


id: GO:0004686
name: elongation factor-2 kinase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: ATP + [elongation factor 2] = ADP + [elongation factor 2] phosphate." [EC:2.7.11.20, MetaCyc:2.7.11.20-RXN]


id: GO:0004687
name: myosin light chain kinase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: ATP + myosin-light-chain = ADP + myosin-light-chain phosphate." [EC:2.7.11.18]


id: GO:0004690
name: cyclic nucleotide-dependent protein kinase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires the presence of a cyclic nucleotide." [GOC:mah]


id: GO:0004691
name: cAMP-dependent protein kinase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires the presence of cAMP." [EC:2.7.11.11]


id: GO:0004692
name: cGMP-dependent protein kinase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires the presence of cGMP." [GOC:mah]


id: GO:0004693
name: cyclin-dependent protein serine/threonine kinase activity
namespace: molecular_function
def:
  "Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. This reaction requires the binding of a regulatory cyclin subunit and full activity requires stimulatory phosphorylation by a CDK-activating kinase (CAK)." [GOC:pr, GOC:rn, PMID:7877684, PMID:9841670]


id: GO:0004694
name: eukaryotic translation initiation factor 2alpha kinase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: ATP + [eukaryotic translation initiation factor 2 alpha subunit] = ADP + [eukaryotic translation initiation factor 2 alpha subunit] phosphate." [GOC:mah, InterPro:IPR015516]


id: GO:0004697
name: protein kinase C activity
namespace: molecular_function
def:
  "Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires diacylglycerol." [EC:2.7.11.13]


id: GO:0004698
name: calcium-dependent protein kinase C activity
namespace: molecular_function
def:
  "Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires diacylglycerol and calcium." [EC:2.7.11.13, GOC:mah]


id: GO:0004699
name: calcium-independent protein kinase C activity
namespace: molecular_function
def:
  "Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires diacylglycerol but not calcium." [EC:2.7.11.13, GOC:mah]


id: GO:0004702
name: receptor signaling protein serine/threonine kinase activity
namespace: molecular_function
def:
  "Conveys a signal from an upstream receptor or intracellular signal transducer by catalysis of the reaction: ATP protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [EC:2.7.11.13, GOC:bf, GOC:mah]


id: GO:0004703
name: G-protein coupled receptor kinase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: ATP + G-protein coupled receptor = ADP + G-protein coupled receptor phosphate." [GOC:dph]


id: GO:0004704
name: NF-kappaB-inducing kinase activity
namespace: molecular_function
def:
  "Catalysis of the phosphorylation of the alpha or beta subunit of the inhibitor of kappaB kinase complex (IKK)." [PMID:20685151]


id: GO:0004705
name: JUN kinase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: JUN + ATP = JUN phosphate + ADP. This reaction is the phosphorylation and activation of members of the JUN family, a gene family that encodes nuclear transcription factors." [GOC:bf, ISBN:0198506732]


id: GO:0004706
name: JUN kinase kinase kinase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: JNKK + ATP = JNKK phosphate + ADP. This reaction is the phosphorylation and activation of JUN kinase kinases (JNKKs)." [GOC:bf]


id: GO:0004707
name: MAP kinase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: protein + ATP = protein phosphate + ADP. This reaction is the phosphorylation of proteins. Mitogen-activated protein kinase; a family of protein kinases that perform a crucial step in relaying signals from the plasma membrane to the nucleus. They are activated by a wide range of proliferation- or differentiation-inducing signals; activation is strong with agonists such as polypeptide growth factors and tumor-promoting phorbol esters, but weak (in most cell backgrounds) by stress stimuli." [GOC:ma, ISBN:0198547684]


id: GO:0004708
name: MAP kinase kinase activity
namespace: molecular_function
def:
  "Catalysis of the concomitant phosphorylation of threonine (T) and tyrosine (Y) residues in a Thr-Glu-Tyr (TEY) thiolester sequence in a MAP kinase (MAPK) substrate." [ISBN:0198547684]


id: GO:0004709
name: MAP kinase kinase kinase activity
namespace: molecular_function
def:
  "Catalysis of the phosphorylation and activation of a MAP kinase kinase; each MAP kinase kinase can be phosphorylated by any of several MAP kinase kinase kinases." [PMID:9561267]


id: GO:0004711
name: ribosomal protein S6 kinase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: ribosomal protein S6 + ATP = ribosomal protein S6 phosphate + ATP." [GOC:mah, PMID:9822608]


id: GO:0004712
name: protein serine/threonine/tyrosine kinase activity
namespace: molecular_function
def:
  "Catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; ATP + a protein threonine = ADP + protein threonine phosphate; and ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [GOC:mah]


id: GO:0004713
name: protein tyrosine kinase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10]


id: GO:0004714
name: transmembrane receptor protein tyrosine kinase activity
namespace: molecular_function
def:
  "Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate." [EC:2.7.10.1, GOC:mah]


id: GO:0004715
name: non-membrane spanning protein tyrosine kinase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: ATP + a non-membrane spanning protein L-tyrosine = ADP + a non-membrane spanning protein L-tyrosine phosphate." [EC:2.7.10.2]


id: GO:0004716
name: receptor signaling protein tyrosine kinase activity
namespace: molecular_function
def:
  "Conveys a signal from an upstream receptor or intracellular signal transducer by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate." [EC:2.7.10.2]


id: GO:0004719
name: protein-L-isoaspartate (D-aspartate) O-methyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: S-adenosyl-L-methionine + protein L-beta-aspartate = S-adenosyl-L-homocysteine + protein L-beta-aspartate methyl ester." [EC:2.1.1.77]


id: GO:0004720
name: protein-lysine 6-oxidase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: peptidyl-L-lysyl-peptide + H2O + O2 = peptidyl-allysyl-peptide + NH3 + hydrogen peroxide." [EC:1.4.3.13]


id: GO:0004721
name: phosphoprotein phosphatase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. Together with protein kinases, these enzymes control the state of phosphorylation of cell proteins and thereby provide an important mechanism for regulating cellular activity." [EC:3.1.3.16, ISBN:0198547684]


id: GO:0004722
name: protein serine/threonine phosphatase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: protein serine phosphate + H2O = protein serine + phosphate, and protein threonine phosphate + H2O = protein threonine + phosphate." [GOC:bf]


id: GO:0004723
name: calcium-dependent protein serine/threonine phosphatase activity
namespace: molecular_function
def:
  "Catalysis of the reactions: protein serine phosphate + H2O = protein serine + phosphate; and protein threonine phosphate + H2O = protein threonine + phosphate. These reactions require the presence of calcium ions." [EC:3.1.3.16, GOC:mah]


id: GO:0004724
name: magnesium-dependent protein serine/threonine phosphatase activity
namespace: molecular_function
def:
  "Catalysis of the reactions: protein serine phosphate + H2O = protein serine + phosphate; and protein threonine phosphate + H2O = protein threonine + phosphate. These reactions require the presence of magnesium." [EC:3.1.3.16]


id: GO:0004725
name: protein tyrosine phosphatase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [EC:3.1.3.48]


id: GO:0004726
name: non-membrane spanning protein tyrosine phosphatase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: non-membrane spanning protein tyrosine phosphate + H2O = non-membrane spanning protein tyrosine + phosphate." [EC:3.1.3.48]


id: GO:0004727
name: prenylated protein tyrosine phosphatase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: prenylated-protein tyrosine phosphate + H2O = prenylated-protein tyrosine + phosphate." [EC:3.1.3.48]


id: GO:0004728
name: receptor signaling protein tyrosine phosphatase activity
namespace: molecular_function
def:
  "Conveys a signal from an upstream receptor or intracellular signal transducer by catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [EC:3.1.3.48]


id: GO:0004729
name: oxygen-dependent protoporphyrinogen oxidase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 3 O(2) + protoporphyrinogen IX = 3 H(2)O(2) + protoporphyrin IX." [EC:1.3.3.4, RHEA:25579]


id: GO:0004730
name: pseudouridylate synthase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: D-ribose 5-phosphate + uracil = H(2)O + pseudouridine 5'-phosphate." [EC:4.2.1.70, RHEA:18340]


id: GO:0004731
name: purine-nucleoside phosphorylase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: purine nucleoside + phosphate = purine + alpha-D-ribose 1-phosphate." [EC:2.4.2.1]


id: GO:0004733
name: pyridoxamine-phosphate oxidase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: pyridoxamine 5'-phosphate + H2O + O2 = pyridoxal 5'-phosphate + NH3 + hydrogen peroxide." [EC:1.4.3.5]


id: GO:0004734
name: pyrimidodiazepine synthase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: a pyrimidodiazepine + oxidized glutathione = 6-pyruvoyltetrahydropterin + 2 glutathione." [EC:1.5.4.1]


id: GO:0004735
name: pyrroline-5-carboxylate reductase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: L-proline + NADP+ = 1-pyrroline-5-carboxylate + NADPH + H+." [EC:1.5.1.2]


id: GO:0004736
name: pyruvate carboxylase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: ATP + bicarbonate + pyruvate = ADP + 2 H(+) + oxaloacetate + phosphate." [EC:6.4.1.1, RHEA:20847]


id: GO:0004740
name: pyruvate dehydrogenase (acetyl-transferring) kinase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: ATP + pyruvate dehydrogenase (acetyl-transferring) = ADP + pyruvate dehydrogenase (acetyl-transferring) phosphate." [EC:2.7.11.2]


id: GO:0004741
name: [pyruvate dehydrogenase (lipoamide)] phosphatase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: [pyruvate dehydrogenase (lipoamide)] phosphate + H2O = [pyruvate dehydrogenase (lipoamide)] + phosphate." [EC:3.1.3.43]


id: GO:0004742
name: dihydrolipoyllysine-residue acetyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: acetyl-CoA + dihydrolipoamide = CoA + S-acetyldihydrolipoamide." [EC:2.3.1.12]


id: GO:0004746
name: riboflavin synthase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 2 6,7-dimethyl-8-(1-D-ribityl)lumazine + H(+) = 5-amino-6-(D-ribitylamino)uracil + riboflavin." [EC:2.5.1.9, RHEA:20775]


id: GO:0004748
name: ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor
namespace: molecular_function
def:
  "Catalysis of the reaction: 2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin. Thioredoxin disulfide is the oxidized form of thioredoxin." [EC:1.17.4.1]


id: GO:0004749
name: ribose phosphate diphosphokinase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: D-ribose 5-phosphate + ATP = 5-phospho-alpha-D-ribose 1-diphosphate + AMP + 2 H(+)." [EC:2.7.6.1, RHEA:15612]


id: GO:0004750
name: ribulose-phosphate 3-epimerase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: D-ribulose 5-phosphate = D-xylulose 5-phosphate." [EC:5.1.3.1, RHEA:13680]


id: GO:0004751
name: ribose-5-phosphate isomerase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: D-ribose 5-phosphate = D-ribulose 5-phosphate." [EC:5.3.1.6, RHEA:14660]


id: GO:0004753
name: saccharopine dehydrogenase activity
namespace: molecular_function
def:
  "Catalysis of the cleavage of N6-(L-1,3-dicarboxypropyl)-L-lysine to release an amino acid (lysine or glutamate), with the concomitant reduction of an electron acceptor." [GOC:mah]


id: GO:0004754
name: saccharopine dehydrogenase (NAD+, L-lysine-forming) activity
namespace: molecular_function
def:
  "Catalysis of the reaction: L-saccharopine + H(2)O + NAD(+) = 2-oxoglutarate + L-lysine + H(+) + NADH." [EC:1.5.1.7, RHEA:12443]


id: GO:0004755
name: saccharopine dehydrogenase (NADP+, L-glutamate-forming) activity
namespace: molecular_function
def:
  "Catalysis of the reaction: L-saccharopine + H(2)O + NADP(+) = L-allysine + L-glutamate + H(+) + NADPH." [EC:1.5.1.10, RHEA:10023]


id: GO:0004756
name: selenide, water dikinase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: ATP + H(2)O + hydrogen selenide = AMP + 3 H(+) + phosphate + selenophosphorate." [EC:2.7.9.3, RHEA:18740]


id: GO:0004757
name: sepiapterin reductase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 7,8-dihydrobiopterin + NADP+ = sepiapterin + NADPH + H+." [EC:1.1.1.153]


id: GO:0004758
name: serine C-palmitoyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: L-serine + H(+) + palmitoyl-CoA = 3-dehydrosphinganine + CO(2) + CoA." [EC:2.3.1.50, RHEA:14764]


id: GO:0004760
name: serine-pyruvate transaminase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: L-serine + pyruvate = 3-hydroxypyruvate + L-alanine." [EC:2.6.1.51, RHEA:22855]


id: GO:0004765
name: shikimate kinase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: ATP + shikimate = 3-phosphoshikimate + ADP + 2 H(+)." [EC:2.7.1.71, RHEA:13124]


id: GO:0004766
name: spermidine synthase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: S-adenosylmethioninamine + putrescine = 5'-methylthioadenosine + spermidine." [EC:2.5.1.16]


id: GO:0004767
name: sphingomyelin phosphodiesterase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: H(2)O + sphingomyelin = ceramide + choline phosphate + H(+)." [EC:3.1.4.12, RHEA:19256]


id: GO:0004768
name: stearoyl-CoA 9-desaturase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: stearoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+ = oleoyl-CoA + 2 ferricytochrome b5 + H2O." [EC:1.14.19.1]


id: GO:0004773
name: steryl-sulfatase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 3-beta-hydroxyandrost-5-en-17-one 3-sulfate + H2O = 3-beta-hydroxyandrost-5-en-17-one + sulfate." [EC:3.1.6.2]


id: GO:0004774
name: succinate-CoA ligase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: succinate + CoA + nucleotide triphosphate = nucleotide diphosphate + phosphate + succinyl-CoA." [EC:6.2.1.-, GOC:ai]


id: GO:0004777
name: succinate-semialdehyde dehydrogenase (NAD+) activity
namespace: molecular_function
def:
  "Catalysis of the reaction: succinate semialdehyde + NAD+ + H2O = succinate + NADH + H+." [EC:1.2.1.24]


id: GO:0004778
name: succinyl-CoA hydrolase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: H(2)O + succinyl-CoA = CoA + H(+) + succinate." [EC:3.1.2.3, RHEA:11519]


id: GO:0004779
name: sulfate adenylyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the transfer of an adenylyl group from an adenosine nucleotide (ATP or ADP) to sulfate, forming adenylylsulfate." [GOC:mah, MetaCyc:SULFATE-ADENYLYLTRANS-RXN, MetaCyc:SULFATE-ADENYLYLTRANSFERASE-ADP-RXN]


id: GO:0004780
name: sulfate adenylyltransferase (ADP) activity
namespace: molecular_function
def:
  "Catalysis of the reaction: ADP + H(+) + sulfate = 5'-adenylyl sulfate + phosphate." [EC:2.7.7.5, RHEA:16532]


id: GO:0004783
name: sulfite reductase (NADPH) activity
namespace: molecular_function
def:
  "Catalysis of the reaction: hydrogen sulfide + 3 NADP+ + 3 H2O = sulfite + 3 NADPH + 3 H+." [EC:1.8.1.2]


id: GO:0004784
name: superoxide dismutase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 2 superoxide + 2 H+ = O2 + hydrogen peroxide." [EC:1.15.1.1, GOC:vw, PMID:15064408]


id: GO:0004789
name: thiamine-phosphate diphosphorylase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 4-amino-2-methyl-5-diphosphomethylpyrimidine + 4-methyl-5-(2-phosphoethyl)-thiazole + H(+) = diphosphate + thiamine phosphate." [EC:2.5.1.3, RHEA:22331]


id: GO:0004790
name: thioether S-methyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: S-adenosyl-L-methionine(1+) + dimethyl sulfide = S-adenosyl-L-homocysteine + trimethylsulfonium." [EC:2.1.1.96, RHEA:19616]


id: GO:0004791
name: thioredoxin-disulfide reductase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: NADP(+) + thioredoxin = H(+) + NADPH + thioredoxin disulfide." [EC:1.8.1.9, RHEA:20348]


id: GO:0004792
name: thiosulfate sulfurtransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: hydrogen cyanide + thiosulfate = H(+) + sulfite + thiocyanate." [EC:2.8.1.1, RHEA:16884]


id: GO:0004798
name: thymidylate kinase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: ATP + thymidine 5'-phosphate = ADP + thymidine 5'-diphosphate." [EC:2.7.4.9]


id: GO:0004799
name: thymidylate synthase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 5,10-methylenetetrahydrofolate + dUMP = 7,8-dihydrofolate + thymidylate." [EC:2.1.1.45, RHEA:12107]


id: GO:0004800
name: thyroxine 5'-deiodinase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 3,5,3'-L-triiodo-L-thyronine + iodide + acceptor + H+ = L-thyroxine + donor-H2." [EC:1.97.1.10]


id: GO:0004801
name: sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate glyceronetransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-erythrose 4-phosphate + D-fructose 6-phosphate." [EC:2.2.1.2]


id: GO:0004802
name: transketolase activity
namespace: molecular_function
def:
  "Catalysis of the reversible transfer of a 2-carbon ketol group (CH2OH-CO-) from a ketose phosphate donor to an aldose phosphate acceptor." [EC:2.2.1.1, GOC:fmc]


id: GO:0004803
name: transposase activity
namespace: molecular_function
def:
  "Catalysis of the transposition of transposable elements or transposons. Transposases are involved in recombination required for transposition and are site-specific for the transposon/transposable element." [GOC:bm, ISBN:0198506732]


id: GO:0004807
name: triose-phosphate isomerase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: D-glyceraldehyde 3-phosphate = glycerone phosphate." [EC:5.3.1.1, RHEA:18588]


id: GO:0004808
name: tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: S-adenosyl-L-methionine + tRNA containing 5-aminomethyl-2-thiouridine = S-adenosyl-L-homocysteine + tRNA containing 5-methylaminomethyl-2-thiouridylate." [EC:2.1.1.61, GOC:imk]


id: GO:0004809
name: tRNA (guanine-N2-)-methyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: S-adenosyl-L-methionine + tRNA containing guanine = S-adenosyl-L-homocysteine + tRNA containing N2-methylguanine." [EC:2.1.1.32]


id: GO:0004812
name: aminoacyl-tRNA ligase activity
namespace: molecular_function
def:
  "Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of diphosphate and AMP." [ISBN:0198506732]


id: GO:0004813
name: alanine-tRNA ligase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: ATP + L-alanine + tRNA(Ala) = AMP + diphosphate + L-alanyl-tRNA(Ala)." [EC:6.1.1.7]


id: GO:0004814
name: arginine-tRNA ligase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg)." [EC:6.1.1.19]


id: GO:0004815
name: aspartate-tRNA ligase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: ATP + L-aspartate + tRNA(Asp) = AMP + diphosphate + L-aspartyl-tRNA(Asp)." [EC:6.1.1.12]


id: GO:0004816
name: asparagine-tRNA ligase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: L-asparagine + ATP + tRNA(Asn) = AMP + Asn-tRNA(Asn) + diphosphate + 2 H(+)." [EC:6.1.1.22, RHEA:11183]


id: GO:0004817
name: cysteine-tRNA ligase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: ATP + L-cysteine + tRNA(Cys) = AMP + diphosphate + L-cysteinyl-tRNA(Cys)." [EC:6.1.1.16]


id: GO:0004818
name: glutamate-tRNA ligase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu)." [EC:6.1.1.17]


id: GO:0004819
name: glutamine-tRNA ligase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: ATP + L-glutamine + tRNA(Gln) = AMP + diphosphate + L-glutaminyl-tRNA(Gln)." [EC:6.1.1.18]


id: GO:0004820
name: glycine-tRNA ligase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: ATP + glycine + tRNA(Gly) = AMP + diphosphate + glycyl-tRNA(Gly)." [EC:6.1.1.14]


id: GO:0004821
name: histidine-tRNA ligase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: ATP + L-histidine + tRNA(His) = AMP + diphosphate + L-histidyl-tRNA(His)." [EC:6.1.1.21]


id: GO:0004822
name: isoleucine-tRNA ligase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: L-isoleucine + ATP + tRNA(Ile) = L-isoleucyl-tRNA(Ile) + AMP + diphosphate + 2 H(+)." [EC:6.1.1.5, RHEA:11063]


id: GO:0004823
name: leucine-tRNA ligase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: L-leucine + ATP + tRNA(Leu) = AMP + diphosphate + 2 H(+) + Leu-tRNA(Leu)." [EC:6.1.1.4, RHEA:11691]


id: GO:0004824
name: lysine-tRNA ligase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: ATP + L-lysine + tRNA(Lys) = AMP + diphosphate + L-lysyl-tRNA(Lys)." [EC:6.1.1.6]


id: GO:0004825
name: methionine-tRNA ligase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: ATP + L-methionine + tRNA(Met) = AMP + diphosphate + L-methionyl-tRNA(Met)." [EC:6.1.1.10]


id: GO:0004826
name: phenylalanine-tRNA ligase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + L-phenylalanyl-tRNA(Phe)." [EC:6.1.1.20]


id: GO:0004827
name: proline-tRNA ligase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: ATP + L-proline + tRNA(Pro) = AMP + diphosphate + L-prolyl-tRNA(Pro)." [EC:6.1.1.15]


id: GO:0004828
name: serine-tRNA ligase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: ATP + L-serine + tRNA(Ser) = AMP + diphosphate + L-seryl-tRNA(Ser)." [EC:6.1.1.11]


id: GO:0004829
name: threonine-tRNA ligase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: ATP + L-threonine + tRNA(Thr) = AMP + diphosphate + L-threonyl-tRNA(Thr)." [EC:6.1.1.3]


id: GO:0004830
name: tryptophan-tRNA ligase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophanyl-tRNA(Trp)." [EC:6.1.1.2]


id: GO:0004831
name: tyrosine-tRNA ligase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: L-tyrosine + ATP + tRNA(Tyr) = L-tyrosyl-tRNA(Tyr) + AMP + diphosphate + 2 H(+)." [EC:6.1.1.1, RHEA:10223]


id: GO:0004832
name: valine-tRNA ligase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: L-valine + ATP + tRNA(Val) = L-valyl-tRNA(Val) + AMP + diphosphate + 2 H(+)." [EC:6.1.1.9, RHEA:10707]


id: GO:0004834
name: tryptophan synthase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: L-serine + (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate = L-tryptophan + glyceraldehyde 3-phosphate + H2O." [RHEA:10535]


id: GO:0004835
name: tubulin-tyrosine ligase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: ATP + detyrosinated alpha-tubulin + L-tyrosine = alpha-tubulin + ADP + phosphate." [EC:6.3.2.25]


id: GO:0004838
name: L-tyrosine:2-oxoglutarate aminotransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: L-tyrosine + 2-oxoglutarate = 4-hydroxyphenylpyruvate + L-glutamate." [EC:2.6.1.5]


id: GO:0004839
name: ubiquitin activating enzyme activity
namespace: molecular_function
def:
  "Catalysis of the reaction: E1 + ubiquitin + ATP--> E1-ubiquitin + AMP + PPi, where the E1-ubiquitin linkage is a thioester bond between the C-terminal glycine of Ub and a sulfhydryl side group of an E1 cysteine residue. This is the first step in a cascade of reactions in which ubiquitin is ultimately added to a protein substrate." [GOC:BioGRID, http://www.bostonbiochem.com/E-301.html, PMID:10072378]


id: GO:0004842
name: ubiquitin-protein transferase activity
namespace: molecular_function
def:
  "Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages." [GOC:BioGRID, GOC:jh2, PMID:9635407]


id: GO:0004843
name: thiol-dependent ubiquitin-specific protease activity
namespace: molecular_function
def:
  "Catalysis of the thiol-dependent hydrolysis of a peptide bond formed by the C-terminal glycine of ubiquitin and another protein." [GOC:jh2, ISBN:0120793709]


id: GO:0004844
name: uracil DNA N-glycosylase activity
namespace: molecular_function
def:
  "Catalysis of the cleavage of the N-C1' glycosidic bond between the damaged DNA base and the deoxyribose sugar, releasing a free base and leaving an apyrimidinic (AP) site. Enzymes with this activity recognize and remove uracil bases in DNA that result from the deamination of cytosine or the misincorporation of dUTP opposite an adenine." [GOC:elh, GOC:pr, PMID:9224623]


id: GO:0004845
name: uracil phosphoribosyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: diphosphate + UMP = 5-phospho-alpha-D-ribose 1-diphosphate + uracil." [EC:2.4.2.9, RHEA:13020]


id: GO:0004847
name: urea carboxylase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: ATP + bicarbonate + urea = ADP + 2 H(+) + phosphate + urea-1-carboxylate." [EC:6.3.4.6, RHEA:20899]


id: GO:0004848
name: ureidoglycolate hydrolase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: (S)-ureidoglycolate + H(2)O + 2 H(+) = CO(2) + glyoxylate + 2 NH(4)(+)." [EC:3.5.3.19, RHEA:19812]


id: GO:0004850
name: uridine phosphorylase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: uridine + phosphate = uracil + alpha-D-ribose 1-phosphate." [EC:2.4.2.3]


id: GO:0004851
name: uroporphyrin-III C-methyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 2 S-adenosyl-L-methionine + uroporphyrin III = 2 S-adenosyl-L-homocysteine + precorrin-2." [EC:2.1.1.107]


id: GO:0004852
name: uroporphyrinogen-III synthase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: hydroxymethylbilane = H(2)O + uroporphyrinogen III." [EC:4.2.1.75, RHEA:18968]


id: GO:0004856
name: xylulokinase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: D-xylulose + ATP = D-xylulose 5-phosphate + ADP + 2 H(+)." [EC:2.7.1.17, RHEA:10967]


id: GO:0004859
name: phospholipase inhibitor activity
namespace: molecular_function
def:
  "Stops, prevents or reduces the activity of a phospholipase, an enzyme that catalyzes of the hydrolysis of a phospholipid." [GOC:ai, GOC:rl]


id: GO:0004860
name: protein kinase inhibitor activity
namespace: molecular_function
def:
  "Stops, prevents or reduces the activity of a protein kinase, an enzyme which phosphorylates a protein." [GOC:ai]


id: GO:0004861
name: cyclin-dependent protein serine/threonine kinase inhibitor activity
namespace: molecular_function
def:
  "Stops, prevents or reduces the activity of a cyclin-dependent protein serine/threonine kinase." [GOC:mah, GOC:pr]


id: GO:0004864
name: protein phosphatase inhibitor activity
namespace: molecular_function
def:
  "Stops, prevents or reduces the activity of a protein phosphatase, an enzyme that hydrolyzes phosphate groups from phosphorylated proteins." [GOC:ai]


id: GO:0004865
name: protein serine/threonine phosphatase inhibitor activity
namespace: molecular_function
def:
  "Stops, prevents or reduces the activity of a serine/threonine protein phosphatase, an enzyme that catalyzes the reaction: protein serine/threonine phosphate + H2O = protein serine/threonine + phosphate." [GOC:dph, GOC:tb]


id: GO:0004866
name: endopeptidase inhibitor activity
namespace: molecular_function
def:
  "Stops, prevents or reduces the activity of an endopeptidase, any enzyme that hydrolyzes nonterminal peptide bonds in polypeptides." [GOC:jl]


id: GO:0004867
name: serine-type endopeptidase inhibitor activity
namespace: molecular_function
def:
  "Stops, prevents or reduces the activity of serine-type endopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain; a serine residue (and a histidine residue) are at the active center of the enzyme." [GOC:ai]


id: GO:0004868
name: obsolete serpin
namespace: molecular_function
def:
  "OBSOLETE. A superfamily of proteins, many of which inhibit serine proteinases and exhibit a high degree of homology with classical serine proteinase inhibitors such as alpha1-antitrypsin or antithrombin." [GOC:ai, ISBN:0198506732]


id: GO:0004869
name: cysteine-type endopeptidase inhibitor activity
namespace: molecular_function
def:
  "Stops, prevents or reduces the activity of a cysteine-type endopeptidase, any enzyme that hydrolyzes peptide bonds in polypeptides by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:dph, GOC:tb]


id: GO:0004871
name: signal transducer activity
namespace: molecular_function
def:
  "Conveys a signal across a cell to trigger a change in cell function or state. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:go_curators]


id: GO:0004872
name: receptor activity
namespace: molecular_function
def:
  "Combining with an extracellular or intracellular messenger to initiate a change in cell activity." [GOC:ceb, ISBN:0198506732]


id: GO:0004873
name: asialoglycoprotein receptor activity
namespace: molecular_function
def:
  "Receiving an asialoglycoprotein, and delivering the asialoglycoprotein into the cell via endocytosis. An asialoglycoprotein is a plasma glycoproteins from which the terminal sialic acid residue on their complex carbohydrate groups has been removed. The asialoglycoprotein receptor recognizes the terminal galactose and N-acetylgalactosamine units of the asialoglycoprotein, the receptor-ligand complex is internalized and transported to a sorting organelle where disassociation occurs before the receptor is recycled to the cell membrane." [GOC:bf, PMID:11278827, PMID:7624395, Wikipedia:Asialoglycoprotein]


id: GO:0004874
name: aryl hydrocarbon receptor activity
namespace: molecular_function
def:
  "Combining with an aryl hydrocarbon and transmitting the signal to initiate a change in cell activity. The aryl hydrocarbon receptor is a ligand-activated transcription factor which translocates to the nucleus to activate transcription upon ligand-binding." [GOC:ai, GOC:signaling, PMID:1325649, PMID:7493958]


id: GO:0004875
name: complement receptor activity
namespace: molecular_function
def:
  "Combining with any component or product of the complement cascade and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:add, GOC:signaling, ISBN:0781735149, PMID:11884446]


id: GO:0004876
name: complement component C3a receptor activity
namespace: molecular_function
def:
  "Combining with the C3a product of the complement cascade and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:add, GOC:signaling, ISBN:0781735149]


id: GO:0004877
name: complement component C3b receptor activity
namespace: molecular_function
def:
  "Combining with the C3b product of the complement cascade and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:add, GOC:signaling, ISBN:0781735149]


id: GO:0004878
name: complement component C5a receptor activity
namespace: molecular_function
def:
  "Combining with the C5a product of the complement cascade and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:add, GOC:signaling, ISBN:0781735149]


id: GO:0004879
name: RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding
namespace: molecular_function
def:
  "Combining with a signal and transmitting the signal to the transcriptional machinery by interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription by RNA polymerase II." [GOC:signaling, GOC:txnOH]


id: GO:0004880
name: juvenile hormone receptor activity
namespace: molecular_function
def:
  "Combining with juvenile hormone and transmitting the signal to the transcriptional machinery by interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription by RNA polymerase II." [GOC:signaling, PMID:15475158]


id: GO:0004882
name: androgen receptor activity
namespace: molecular_function
def:
  "Combining with an androgen and transmitting the signal to the transcriptional machinery by interacting selectively and non-covalently with an androgen response element in DNA in order to modulate transcription by RNA polymerase II." [GOC:signaling, PMID:19372015]


id: GO:0004883
name: glucocorticoid receptor activity
namespace: molecular_function
def:
  "Combining with a glucocorticoid and transmitting the signal within the cell trigger a change in cell activity or function." [GOC:signaling, PMID:17689856, PMID:20920967]


id: GO:0004884
name: ecdysteroid hormone receptor activity
namespace: molecular_function
def:
  "Combining with an ecdysteroid hormone and transmitting the signal to the transcriptional machinery by interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription by RNA polymerase II." [GOC:signaling, PMID:1653701]


id: GO:0004886
name: 9-cis retinoic acid receptor activity
namespace: molecular_function
def:
  "Combining with 9-cis retinoic acid and transmitting the signal to the transcriptional machinery by interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription by RNA polymerase II." [GOC:signaling, PMID:17132853]


id: GO:0004887
name: thyroid hormone receptor activity
namespace: molecular_function
def:
  "Combining with thyroid hormone and transmitting the signal to the transcriptional machinery by interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription by RNA polymerase II." [GOC:signaling]


id: GO:0004888
name: transmembrane signaling receptor activity
namespace: molecular_function
def:
  "Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity or state as part of signal transduction." [GOC:go_curators, Wikipedia:Transmembrane_receptor]


id: GO:0004889
name: acetylcholine-activated cation-selective channel activity
namespace: molecular_function
def:
  "Enables the transmembrane transfer of a cation by a channel that opens upon binding acetylcholine." [GOC:mah, PMID:2466967]


id: GO:0004890
name: GABA-A receptor activity
namespace: molecular_function
def:
  "Combining with the amino acid gamma-aminobutyric acid (GABA, 4-aminobutyrate) to initiate a change in cell activity. GABA-A receptors function as chloride channels." [PMID:8974333]


id: GO:0004896
name: cytokine receptor activity
namespace: molecular_function
def:
  "Combining with a cytokine and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:add, GOC:mah]


id: GO:0004897
name: ciliary neurotrophic factor receptor activity
namespace: molecular_function
def:
  "Combining with ciliary neurotrophic factor (CNTF) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:mah, GOC:signaling]


id: GO:0004900
name: erythropoietin receptor activity
namespace: molecular_function
def:
  "Combining with erythropoietin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:ai, GOC:signaling]


id: GO:0004901
name: granulocyte macrophage colony-stimulating factor receptor activity
namespace: molecular_function
def:
  "Combining with granulocyte macrophage colony-stimulating factor (GM-CSF) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:mah, GOC:signaling]


id: GO:0004902
name: granulocyte colony-stimulating factor receptor activity
namespace: molecular_function
def:
  "Combining with granulocyte colony-stimulating factor (G-CSF) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:mah, GOC:signaling]


id: GO:0004903
name: growth hormone receptor activity
namespace: molecular_function
def:
  "Combining with a growth hormone and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:ai, GOC:signaling]


id: GO:0004904
name: interferon receptor activity
namespace: molecular_function
def:
  "Combining with an interferon and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:ai, GOC:signaling, PMID:9607096]


id: GO:0004905
name: type I interferon receptor activity
namespace: molecular_function
def:
  "Combining with a type I interferon and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. Type I interferons include the interferon-alpha, beta, delta, epsilon, zeta, kappa, tau, and omega gene families." [GOC:add, GOC:signaling, ISBN:0126896631, PMID:15546383, PMID:16681834, PR:000025848]


id: GO:0004906
name: interferon-gamma receptor activity
namespace: molecular_function
def:
  "Combining with interferon-gamma (a type II interferon) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:add, GOC:ai, GOC:signaling, ISBN:0126896631, PMID:15546383]


id: GO:0004908
name: interleukin-1 receptor activity
namespace: molecular_function
def:
  "Combining with interleukin-1 to initiate a change in cell activity. Interleukin-1 is produced mainly by activated macrophages and is involved in the inflammatory response." [GOC:jl]


id: GO:0004909
name: interleukin-1, Type I, activating receptor activity
namespace: molecular_function
def:
  "Combining with interleukin-1 to initiate a change in cell activity via signaling pathways and mediated by adaptor proteins." [PMID:15062641, PMID:18613828]


id: GO:0004910
name: interleukin-1, Type II, blocking receptor activity
namespace: molecular_function
def:
  "Combining with interleukin-1 to initiate a change in cell activity by inhibiting the activity of type I interleukin receptors." [PMID:15062641, PMID:18613828]


id: GO:0004911
name: interleukin-2 receptor activity
namespace: molecular_function
def:
  "Combining with interleukin-2 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:jl, GOC:signaling]


id: GO:0004912
name: interleukin-3 receptor activity
namespace: molecular_function
def:
  "Combining with interleukin-3 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:jl, GOC:signaling]


id: GO:0004913
name: interleukin-4 receptor activity
namespace: molecular_function
def:
  "Combining with interleukin-4 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:jl, GOC:signaling]


id: GO:0004914
name: interleukin-5 receptor activity
namespace: molecular_function
def:
  "Combining with interleukin-5 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:jl, GOC:signaling]


id: GO:0004915
name: interleukin-6 receptor activity
namespace: molecular_function
def:
  "Combining with interleukin-6 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:jl, GOC:signaling]


id: GO:0004917
name: interleukin-7 receptor activity
namespace: molecular_function
def:
  "Combining with interleukin-7 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:jl, GOC:signaling]


id: GO:0004918
name: interleukin-8 receptor activity
namespace: molecular_function
def:
  "Combining with interleukin-8 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:jl, GOC:signaling]


id: GO:0004919
name: interleukin-9 receptor activity
namespace: molecular_function
def:
  "Combining with interleukin-9 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:jl, GOC:signaling]


id: GO:0004920
name: interleukin-10 receptor activity
namespace: molecular_function
def:
  "Combining with interleukin-10 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:jl, GOC:signaling]


id: GO:0004921
name: interleukin-11 receptor activity
namespace: molecular_function
def:
  "Combining with interleukin-11 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:jl, GOC:signaling]


id: GO:0004923
name: leukemia inhibitory factor receptor activity
namespace: molecular_function
def:
  "Combining with leukemia inhibitory factor (LIF) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:bf, GOC:mah, GOC:signaling]


id: GO:0004924
name: oncostatin-M receptor activity
namespace: molecular_function
def:
  "Combining with oncostatin-M and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:mah, GOC:signaling]


id: GO:0004925
name: prolactin receptor activity
namespace: molecular_function
def:
  "Combining with prolactin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:mah, GOC:signaling]


id: GO:0004928
name: obsolete frizzled receptor activity
namespace: molecular_function
def:
  "OBSOLETE. Combining with a member of the Wnt-family of signaling molecules to initiate a change in cell activity." [GOC:go_curators]


id: GO:0004929
name: obsolete frizzled-2 receptor activity
namespace: molecular_function
def:
  "OBSOLETE. Combining with to a member of the Wnt-family of signaling molecules to initiate a change in cell activity." [GOC:go_curators]


id: GO:0004930
name: G-protein coupled receptor activity
namespace: molecular_function
def:
  "Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]


id: GO:0004931
name: extracellular ATP-gated cation channel activity
namespace: molecular_function
def:
  "Enables the transmembrane transfer of a cation by a channel that opens when extracellular ATP has been bound by the channel complex or one of its constituent parts." [GOC:bf, GOC:mah, PMID:9755289]


id: GO:0004932
name: mating-type factor pheromone receptor activity
namespace: molecular_function
def:
  "Combining with a mating-type factor pheromone to initiate a change in cell activity." [GOC:dph, GOC:vw]


id: GO:0004933
name: mating-type a-factor pheromone receptor activity
namespace: molecular_function
def:
  "Combining with the mating-type a-factor pheromone to initiate a change in cell activity." [GOC:mah]


id: GO:0004934
name: mating-type alpha-factor pheromone receptor activity
namespace: molecular_function
def:
  "Combining with the mating-type alpha-factor pheromone to initiate a change in cell activity." [GOC:mah]


id: GO:0004935
name: adrenergic receptor activity
namespace: molecular_function
def:
  "Combining with epinephrine or norepinephrine and transmitting the signal across the membrane by activating the alpha-subunit of an associated heterotrimeric G-protein complex." [GOC:bf, GOC:mah, IUPHAR_GPCR:1274]


id: GO:0004936
name: alpha-adrenergic receptor activity
namespace: molecular_function
def:
  "Combining with epinephrine or norepinephrine to initiate a change in cell activity via activation of a G protein, with pharmacological characteristics of alpha-adrenergic receptors." [GOC:mah, IUPHAR_GPCR:1274]


id: GO:0004937
name: alpha1-adrenergic receptor activity
namespace: molecular_function
def:
  "Combining with epinephrine or norepinephrine to initiate a change in cell activity via activation of a G protein, with pharmacological characteristics of alpha1-adrenergic receptors; the activity involves transmitting the signal to the Gq alpha subunit of a heterotrimeric G protein." [GOC:cb, GOC:mah, IUPHAR_GPCR:1274]


id: GO:0004938
name: alpha2-adrenergic receptor activity
namespace: molecular_function
def:
  "Combining with epinephrine or norepinephrine to initiate a change in cell activity via activation of a G protein, with pharmacological characteristics of alpha2-adrenergic receptors; the activity involves transmitting the signal to the Gi alpha subunit of a heterotrimeric G protein." [GOC:cb, GOC:mah, IUPHAR_GPCR:1274]


id: GO:0004939
name: beta-adrenergic receptor activity
namespace: molecular_function
def:
  "Combining with epinephrine or norepinephrine to initiate a change in cell activity via activation of a G protein, with pharmacological characteristics of beta-adrenergic receptors; the activity involves transmitting the signal to the Gs alpha subunit of a heterotrimeric G protein." [GOC:cb, GOC:mah, IUPHAR_GPCR:1274]


id: GO:0004940
name: beta1-adrenergic receptor activity
namespace: molecular_function
def:
  "Combining with epinephrine or norepinephrine to initiate a change in cell activity via activation of a G protein, with pharmacological characteristics of beta1-adrenergic receptors." [GOC:mah, IUPHAR_GPCR:1274]


id: GO:0004941
name: beta2-adrenergic receptor activity
namespace: molecular_function
def:
  "Combining with epinephrine or norepinephrine to initiate a change in cell activity via activation of a G protein, with pharmacological characteristics of beta2-adrenergic receptors." [GOC:mah, IUPHAR_GPCR:1274]


id: GO:0004945
name: angiotensin type II receptor activity
namespace: molecular_function
def:
  "An angiotensin receptor activity that acts via Gi protein coupling and cGMP (NO) generation, and may also act via additional signaling mechanisms." [GOC:mah, PMID:10977869]


id: GO:0004948
name: calcitonin receptor activity
namespace: molecular_function
def:
  "Combining with calcitonin and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:mah, GOC:signaling, PMID:21649645]


id: GO:0004949
name: cannabinoid receptor activity
namespace: molecular_function
def:
  "Combining with a cannabinoid to initiate a change in cell activity. Cannabinoids are a class of diverse chemical compounds that include the endocannabinoids and the phytocannabinoids." [GOC:dph, IUPHAR_GPCR:1279, Wikipedia:Cannabinoid]


id: GO:0004950
name: chemokine receptor activity
namespace: molecular_function
def:
  "Combining with a chemokine, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. Chemokines are a family of small chemotactic cytokines; their name is derived from their ability to induce directed chemotaxis in nearby responsive cells. All chemokines possess a number of conserved cysteine residues involved in intramolecular disulfide bond formation. Some chemokines are considered pro-inflammatory and can be induced during an immune response to recruit cells of the immune system to a site of infection, while others are considered homeostatic and are involved in controlling the migration of cells during normal processes of tissue maintenance or development. Chemokines are found in all vertebrates, some viruses and some bacteria." [GOC:BHF, GOC:rl, GOC:signaling, http://en.wikipedia.org/wiki/Chemokine, IUPHAR_GPCR:1280, PMID:12183377, PMID:8662823]


id: GO:0004951
name: cholecystokinin receptor activity
namespace: molecular_function
def:
  "Combining with cholecystokinin and transmitting the signal across the membrane by activating an associated G-protein to initiate a change in cell activity. Cholecystokinin can act as a neuropeptide or as a gastrointestinal hormone." [GOC:signaling, PMID:9835394]


id: GO:0004952
name: dopamine neurotransmitter receptor activity
namespace: molecular_function
def:
  "Combining with the neurotransmitter dopamine to initiate a change in cell activity." [IUPHAR_GPCR:1282]


id: GO:0004954
name: prostanoid receptor activity
namespace: molecular_function
def:
  "Combining with a prostanoid, any compound based on or derived from the prostanoate structure, to initiate a change in cell activity." [ISBN:0198506732]


id: GO:0004958
name: prostaglandin F receptor activity
namespace: molecular_function
def:
  "Combining with prostaglandin F (PGF (2-alpha)) to initiate a change in cell activity." [ISBN:0198506732]


id: GO:0004961
name: thromboxane A2 receptor activity
namespace: molecular_function
def:
  "Combining with thromboxane A2 (TXA(2)) and transmitting the signal across the membrane to activate an associated G-protein." [GOC:signaling, ISBN:0198506732]


id: GO:0004962
name: endothelin receptor activity
namespace: molecular_function
def:
  "Combining with endothelin and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, GOC:dph, GOC:signaling, IUPHAR_GPCR:1283, IUPHAR_RECEPTOR:2263, IUPHAR_RECEPTOR:2265]


id: GO:0004964
name: luteinizing hormone receptor activity
namespace: molecular_function
def:
  "Combining with luteinizing hormone (also called lutropin) to initiate a change in cell activity." [ISBN:0198506732, PMID:18848524, PMID:1922095]


id: GO:0004965
name: G-protein coupled GABA receptor activity
namespace: molecular_function
def:
  "Combining with the amino acid gamma-aminobutyric acid (GABA, 4-aminobutyrate) and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:ai, GOC:bf, IUPHAR_RECEPTOR:1276, Wikipedia:GABAB_receptor]


id: GO:0004967
name: glucagon receptor activity
namespace: molecular_function
def:
  "Combining with glucagon and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:mah, GOC:signaling, PMID:22438981]


id: GO:0004968
name: gonadotropin-releasing hormone receptor activity
namespace: molecular_function
def:
  "Combining with gonadotropin-releasing hormone to initiate a change in cell activity. Gonadotropin-releasing hormone (GnRH) is a peptide hormone responsible for the release of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) from the anterior pituitary. GnRH is synthesized and released by the hypothalamus." [GOC:mah]


id: GO:0004969
name: histamine receptor activity
namespace: molecular_function
def:
  "Combining with histamine to initiate a change in cell activity. Histamine is a physiologically active amine, found in plant and animal tissue and released from mast cells as part of an allergic reaction in humans." [GOC:ai]


id: GO:0004970
name: ionotropic glutamate receptor activity
namespace: molecular_function
def:
  "Catalysis of the transmembrane transfer of an ion by a channel that opens when glutamate has been bound by the channel complex or one of its constituent parts." [ISBN:0198506732]


id: GO:0004971
name: AMPA glutamate receptor activity
namespace: molecular_function
def:
  "An ionotropic glutamate receptor activity that exhibits fast gating by glutamate and acts by opening a cation channel permeable to sodium, potassium, and, in the absence of a GluR2 subunit, calcium." [GOC:mah, PMID:10049997, PMID:8804111]


id: GO:0004972
name: NMDA glutamate receptor activity
namespace: molecular_function
def:
  "An ionotropic glutamate receptor activity that exhibits slow gating by glutamate, acts by opening a nonselective cation channel, and can be activated by L-aspartate." [GOC:mah, PMID:10049997]


id: GO:0004974
name: leukotriene receptor activity
namespace: molecular_function
def:
  "Combining with a leukotriene to initiate a change in cell activity. Leukotrienes are pharmacologically active substances with a set of three conjugated double bonds; some contain a peptide group based on cysteine." [GOC:ai, ISBN:0198506732]


id: GO:0004979
name: beta-endorphin receptor activity
namespace: molecular_function
def:
  "Combining with beta-endorphin, and transmitting the signal across the membrane by activating an associated G-protein. Beta-endorphin is a peptide, 31 amino acids long, resulting from processing of the precursor proopiomelanocortin (POMC)." [GOC:ai, GOC:bf, Wikipedia:Beta-endorphin]


id: GO:0004980
name: melanocyte-stimulating hormone receptor activity
namespace: molecular_function
def:
  "Combining with melanocyte-stimulating hormone to initiate a change in cell activity." [GOC:jl, PMID:7581459]


id: GO:0004984
name: olfactory receptor activity
namespace: molecular_function
def:
  "Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441]


id: GO:0004985
name: opioid receptor activity
namespace: molecular_function
def:
  "Combining with an opioid (any narcotic derived from or resembling opium), and transmitting the signal across the membrane by activating an associated G-protein." [CHEBI:60598, GOC:ai, GOC:bf, PMID:20494127]


id: GO:0004986
name: obsolete delta-opioid receptor activity
namespace: molecular_function
def:
  "OBSOLETE. Combining with an opioid to initiate a change in cell activity, with the pharmacological characteristics of delta-opioid receptors, including the activity of enkephalins as ligands." [IUPHAR_RECEPTOR:317, PMID:10471416]


id: GO:0004987
name: obsolete kappa-opioid receptor activity
namespace: molecular_function
def:
  "OBSOLETE. Combining with an opioid to initiate a change in cell activity, with the pharmacological characteristics of kappa-opioid receptors, including high affinity for dynorphins." [IUPHAR_RECEPTOR:318]


id: GO:0004988
name: obsolete mu-opioid receptor activity
namespace: molecular_function
def:
  "OBSOLETE. Combining with an opioid to initiate a change in cell activity, with the pharmacological characteristics of mu-opioid receptors, including high affinity for enkephalins and beta-endorphin but low affinity for dynorphins." [IUPHAR_RECEPTOR:319]


id: GO:0004989
name: octopamine receptor activity
namespace: molecular_function
def:
  "Combining with the biogenic amine octopamine to initiate a change in cell activity. Octopamine is found in both vertebrates and invertebrates and can have properties both of a hormone and a neurotransmitter and acts as an adrenergic agonist." [CHEBI:17134, GOC:ai]


id: GO:0004993
name: G-protein coupled serotonin receptor activity
namespace: molecular_function
def:
  "Combining with the biogenic amine serotonin and transmitting the signal across the membrane by activating an associated G-protein. Serotonin (5-hydroxytryptamine) is a neurotransmitter and hormone found in vertebrates and invertebrates." [CHEBI:28790, GOC:ai]


id: GO:0004994
name: somatostatin receptor activity
namespace: molecular_function
def:
  "Combining with somatostatin to initiate a change in cell activity. Somatostatin is a peptide hormone that regulates the endocrine system by signaling via G-protein coupled somatostatin receptors. Somatostatin has two active forms produced by proteolytic cleavage: a 14 amino acid peptide (SST-14) and a 28 amino acid peptide (SST-28)." [GOC:ai, GOC:bf, Wikipedia:Somatostatin]


id: GO:0004995
name: tachykinin receptor activity
namespace: molecular_function
def:
  "Combining with a tachykinin neuropeptide and transmitting the signal across the membrane by activating an associated G-protein." [GOC:ai, GOC:bf, PMID:7639617, Wikipedia:Tachykinin]


id: GO:0004998
name: transferrin receptor activity
namespace: molecular_function
def:
  "Combining selectively with transferrin, and delivering transferrin into the cell via endocytosis. Transferrin is a major iron carrier protein in vertebrates." [GOC:bf, PMID:2678449, PMID:3011819]


id: GO:0005001
name: transmembrane receptor protein tyrosine phosphatase activity
namespace: molecular_function
def:
  "Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [EC:3.1.3.48]


id: GO:0005004
name: GPI-linked ephrin receptor activity
namespace: molecular_function
def:
  "Combining with a GPI-anchored ephrin to initiate a change in cell activity." [GOC:mah, PMID:9530499]


id: GO:0005005
name: transmembrane-ephrin receptor activity
namespace: molecular_function
def:
  "Combining with a transmembrane ephrin to initiate a change in cell activity." [GOC:mah, PMID:9530499]


id: GO:0005006
name: epidermal growth factor-activated receptor activity
namespace: molecular_function
def:
  "Combining with an epidermal growth factor and transmitting the signal across the plasma membrane to initiate a change in cell activity." [GOC:bf]


id: GO:0005007
name: fibroblast growth factor-activated receptor activity
namespace: molecular_function
def:
  "Combining with a fibroblast growth factor and transmitting the signal across the plasma membrane to initiate a change in cell activity." [GOC:mah]


id: GO:0005008
name: hepatocyte growth factor-activated receptor activity
namespace: molecular_function
def:
  "Combining with hepatocyte growth factor and transmitting the signal across the plasma membrane to initiate a change in cell activity." [GOC:mah]


id: GO:0005009
name: insulin-activated receptor activity
namespace: molecular_function
def:
  "Combining with insulin and transmitting the signal across the plasma membrane to initiate a change in cell activity." [ISBN:0198506732]


id: GO:0005010
name: insulin-like growth factor-activated receptor activity
namespace: molecular_function
def:
  "Combining with insulin-like growth factor and transmitting the signal across the plasma membrane to initiate a change in cell activity." [GOC:mah]


id: GO:0005011
name: macrophage colony-stimulating factor receptor activity
namespace: molecular_function
def:
  "Combining with macrophage colony-stimulating factor (M-CSF) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate." [GOC:mah, GOC:signaling]


id: GO:0005017
name: platelet-derived growth factor-activated receptor activity
namespace: molecular_function
def:
  "Combining with platelet-derived growth factor and transmitting the signal across the plasma membrane to initiate a change in cell activity." [GOC:mah]


id: GO:0005018
name: platelet-derived growth factor alpha-receptor activity
namespace: molecular_function
def:
  "Combining with platelet-derived growth factor isoform PDGF-AA, PDGF-BB or PDGF-AB to initiate a change in cell activity." [PMID:1657917]


id: GO:0005019
name: platelet-derived growth factor beta-receptor activity
namespace: molecular_function
def:
  "Combining with platelet-derived growth factor isoform PDGF-BB or PDGF-AB to initiate a change in cell activity." [PMID:1657917]


id: GO:0005020
name: stem cell factor receptor activity
namespace: molecular_function
def:
  "Combining with stem cell factor (SCF) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate. Stem cell factor is a cytokine that stimulates mast cell growth and differentiation." [GOC:jl, GOC:signaling, PMID:10698217]


id: GO:0005021
name: vascular endothelial growth factor-activated receptor activity
namespace: molecular_function
def:
  "Combining with a vascular endothelial growth factor (VEGF) and transmitting the signal across the plasma membrane to initiate a change in cell activity." [GOC:mah, GOC:signaling]


id: GO:0005024
name: transforming growth factor beta-activated receptor activity
namespace: molecular_function
def:
  "Combining with a transforming growth factor beta (TGFbeta) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:mah, GOC:signaling]


id: GO:0005025
name: transforming growth factor beta receptor activity, type I
namespace: molecular_function
def:
  "Combining with a complex of transforming growth factor beta and a type II TGF-beta receptor to initiate a change in cell activity; upon binding, acts as a downstream transducer of TGF-beta signals." [GOC:mah, Reactome:REACT_6945.1]


id: GO:0005026
name: transforming growth factor beta receptor activity, type II
namespace: molecular_function
def:
  "Combining with transforming growth factor beta to initiate a change in cell activity; upon ligand binding, binds to and catalyzes the phosphorylation of a type I TGF-beta receptor." [GOC:mah, Reactome:REACT_6872.1]


id: GO:0005030
name: neurotrophin receptor activity
namespace: molecular_function
def:
  "Combining with a neurotrophin, any of a family of growth factors that prevent apoptosis in neurons and promote nerve growth, and transmitting the signal to initiate a change in cell activity." [GOC:jl, GOC:signaling, http://www.mercksource.com/]


id: GO:0005031
name: tumor necrosis factor-activated receptor activity
namespace: molecular_function
def:
  "Combining with tumor necrosis factor, a proinflammatory cytokine produced by monocytes and macrophages, to initiate a change in cell function." [GOC:jl, http://lookwayup.com/]


id: GO:0005034
name: osmosensor activity
namespace: molecular_function
def:
  "Sensing extracellular osmolarity to initiate a change in cell activity, and spanning the membrane of the cell." [GOC:dph, GOC:tb]


id: GO:0005035
name: death receptor activity
namespace: molecular_function
def:
  "Combining with an extracellular messenger (called a death ligand), and transmitting the signal from one side of the plasma membrane to the other to initiate apoptotic or necrotic cell death." [GOC:bf, GOC:BHF, GOC:ecd, GOC:mtg_apoptosis, GOC:rl, PMID:10209153]


id: GO:0005040
name: decoy death receptor activity
namespace: molecular_function
def:
  "Combining with an extracellular messenger (death ligand) without transmission of the signal. Decoy death receptors compete with death receptors for ligand binding, and do not initiate apoptosis." [GOC:bf, GOC:ecd, PMID:10209153]


id: GO:0005041
name: low-density lipoprotein receptor activity
namespace: molecular_function
def:
  "Combining with a low-density lipoprotein particle and delivering the low-density lipoprotein into the cell via endocytosis." [GOC:bf, ISBN:0198506732]


id: GO:0005042
name: netrin receptor activity
namespace: molecular_function
def:
  "Combining with a netrin signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:dph, GOC:signaling, PMID:15960985]


id: GO:0005043
name: netrin receptor activity involved in chemorepulsion
namespace: molecular_function
def:
  "Combining with a netrin signal and transmitting the signal from one side of the membrane to the other to contribute to the directed movement of a motile cell away from a higher concentration of netrin." [GOC:dph, GOC:signaling]


id: GO:0005044
name: scavenger receptor activity
namespace: molecular_function
def:
  "Combining with any modified low-density lipoprotein (LDL) or other polyanionic ligand and delivering the ligand into the cell via endocytosis. Ligands include acetylated and oxidized LDL, Gram-positive and Gram-negative bacteria, apoptotic cells, beta-amyloid fibrils, and advanced glycation end products (AGEs)." [GOC:bf, PMID:11790542, PMID:12379907, PMID:12621157, PMID:20981357]


id: GO:0005046
name: KDEL sequence binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with a KDEL sequence, the C terminus tetrapeptide sequence Lys-Asp-Glu-Leu found in proteins that are to be retained in the endoplasmic reticulum." [GOC:ai]


id: GO:0005047
name: signal recognition particle binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with the signal recognition particle." [ISBN:0198506732]


id: GO:0005048
name: signal sequence binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with a signal sequence, a specific peptide sequence found on protein precursors or mature proteins that dictates where the mature protein is localized." [GOC:ai]


id: GO:0005049
name: nuclear export signal receptor activity
namespace: molecular_function
def:
  "Combining with a nuclear export signal (NES) to mediate transport of the NES-containing protein through the nuclear pore to the cytoplasm." [GOC:bf, GOC:mah, GOC:vw, PMID:11743003, PMID:12486120]


id: GO:0005052
name: peroxisome matrix targeting signal-1 binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with a type 1 peroxisome targeting signal, a tripeptide with the consensus sequence (S/A/C)-(K/R/H)-L." [GOC:mah, PMID:11687502]


id: GO:0005053
name: peroxisome matrix targeting signal-2 binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with a type 2 peroxisome targeting signal, a nonapeptide with a broad consensus sequence of (R/K)-(L/V/I)-(XXXXX)-(H/Q)-(L/A/F)." [GOC:mah, PMID:11687502]


id: GO:0005055
name: laminin receptor activity
namespace: molecular_function
def:
  "Combining with a laminin, a glycoprotein that constitutes the majority of proteins in the basement membrane, to initiate a change in cell activity." [GOC:ai, PMID:2970671]


id: GO:0005056
name: tiggrin receptor activity
namespace: molecular_function
def:
  "Combining with the extracellular matrix ligand tiggrin, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:mah, GOC:signaling, PMID:9521906]


id: GO:0005057
name: receptor signaling protein activity
namespace: molecular_function
def:
  "Conveys a signal from an upstream receptor or intracellular signal transducer, converting the signal into a form where it can ultimately trigger a change in the state or activity of a cell." [GOC:bf]


id: GO:0005068
name: transmembrane receptor protein tyrosine kinase adaptor activity
namespace: molecular_function
def:
  "The binding activity of a molecule that brings together a transmembrane receptor protein tyrosine kinase and one or more other molecules, permitting them to function in a coordinated way." [GOC:mtg_MIT_16mar07, PMID:10502414, PMID:20565848]


id: GO:0005070
name: SH3/SH2 adaptor activity
namespace: molecular_function
def:
  "Interacting selectively and non-covalently and simultaneously with one or more signal transduction molecules, usually acting as a scaffold to bring these molecules into close proximity either using their own SH2/SH3 domains (e.g. Grb2) or those of their target molecules (e.g. SAM68)." [GOC:mah, GOC:so]


id: GO:0005072
name: transforming growth factor beta receptor, cytoplasmic mediator activity
namespace: molecular_function
def:
  "Activity of any of the molecules that transmit the signal from a TGF-beta receptor through the cytoplasm to the nucleus." [GOC:hjd]


id: GO:0005078
name: MAP-kinase scaffold activity
namespace: molecular_function
def:
  "The binding activity of a molecule that functions as a physical support for the assembly of a multiprotein mitogen-activated protein kinase (MAPK) complex. Binds multiple kinases of the MAPKKK cascade, and also upstream signaling proteins, permitting those molecules to function in a coordinated way. Bringing together multiple enzymes and their substrates enables the signal to be transduced quickly and efficiently." [PMID:12511654, PMID:15213240, PMID:9405336]


id: GO:0005079
name: obsolete protein kinase A anchoring activity
namespace: molecular_function
def:
  "OBSOLETE. Binds to protein kinase A and anchors it to a particular subcellular location." [PMID:10354567]


id: GO:0005085
name: guanyl-nucleotide exchange factor activity
namespace: molecular_function
def:
  "Stimulates the exchange of guanyl nucleotides associated with a GTPase. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:kd, GOC:mah]


id: GO:0005086
name: ARF guanyl-nucleotide exchange factor activity
namespace: molecular_function
def:
  "Stimulates the exchange of guanyl nucleotides associated with the GTPase ARF. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:mah]


id: GO:0005087
name: Ran guanyl-nucleotide exchange factor activity
namespace: molecular_function
def:
  "Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Ran family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:mah]


id: GO:0005088
name: Ras guanyl-nucleotide exchange factor activity
namespace: molecular_function
def:
  "Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Ras superfamily. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:mah]


id: GO:0005089
name: Rho guanyl-nucleotide exchange factor activity
namespace: molecular_function
def:
  "Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rho family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:mah]


id: GO:0005090
name: Sar guanyl-nucleotide exchange factor activity
namespace: molecular_function
def:
  "Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Sar family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:mah]


id: GO:0005091
name: guanyl-nucleotide exchange factor adaptor activity
namespace: molecular_function
def:
  "The binding activity of a molecule that brings together a guanyl-nucleotide exchange factor and one or more other proteins, permitting them to function in a coordinated way." [GOC:mtg_MIT_16mar07, GOC:vw]


id: GO:0005093
name: Rab GDP-dissociation inhibitor activity
namespace: molecular_function
def:
  "Prevents the dissociation of GDP from the small GTPase Rab, thereby preventing GTP from binding." [GOC:mah]


id: GO:0005094
name: Rho GDP-dissociation inhibitor activity
namespace: molecular_function
def:
  "Prevents the dissociation of GDP from the small GTPase Rho, thereby preventing GTP from binding." [GOC:mah]


id: GO:0005095
name: GTPase inhibitor activity
namespace: molecular_function
def:
  "Stops, prevents or reduces the activity of any enzyme that catalyzes the hydrolysis of GTP to GDP and orthophosphate." [GOC:ai]


id: GO:0005096
name: GTPase activator activity
namespace: molecular_function
def:
  "Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP." [GOC:mah]


id: GO:0005102
name: receptor binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:bf, GOC:ceb, ISBN:0198506732]


id: GO:0005104
name: fibroblast growth factor receptor binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with the fibroblast growth factor receptor (FGFR)." [GOC:ceb]


id: GO:0005105
name: type 1 fibroblast growth factor receptor binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with the type 1 fibroblast growth factor receptor (FGFR1)." [GOC:ceb, GOC:fb_curators]


id: GO:0005109
name: frizzled binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with the frizzled (fz) receptor." [GOC:ceb, PR:000001315]


id: GO:0005111
name: type 2 fibroblast growth factor receptor binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with the type 2 fibroblast growth factor receptor (FGFR2)." [GOC:fb_curators]


id: GO:0005112
name: Notch binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with the Notch (N) protein, a surface receptor." [GOC:ceb]


id: GO:0005113
name: patched binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with the patched (ptc) protein, a receptor for hedgehog proteins." [GOC:ceb, PMID:11731473]


id: GO:0005114
name: type II transforming growth factor beta receptor binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with a type II transforming growth factor beta receptor." [GOC:ceb, GOC:mah, PMID:11252892]


id: GO:0005115
name: receptor tyrosine kinase-like orphan receptor binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with the receptor tyrosine kinase-like orphan receptor (Ror)." [GOC:ceb, GOC:vw]


id: GO:0005117
name: wishful thinking binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with wishful thinking (Wit), a type II bone morphogenic protein receptor." [GOC:ceb, PMID:11856529]


id: GO:0005118
name: sevenless binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with the sevenless (sev) protein, a receptor tyrosine kinase." [GOC:ceb, PMID:3151175]


id: GO:0005119
name: smoothened binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with the smoothened (smo) protein, which interacts with patched to transmit hedgehog signals." [GOC:ceb, PMID:11731473]


id: GO:0005121
name: Toll binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with the Toll protein, a transmembrane receptor." [GOC:ceb]


id: GO:0005122
name: torso binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with the torso (tor) protein, a receptor tyrosine kinase." [GOC:ceb, PMID:2927509]


id: GO:0005123
name: death receptor binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with any member of the death receptor (DR) family. The DR family falls within the tumor necrosis factor receptor superfamily and is characterized by a cytoplasmic region of ~80 residues termed the death domain (DD)." [GOC:ceb, GOC:rl, PMID:15654015]


id: GO:0005124
name: scavenger receptor binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with scavenger receptors, a family of proteins that are expressed on myeloid cells and are involved in the uptake of effete cellular components and foreign particles." [GOC:ceb]


id: GO:0005125
name: cytokine activity
namespace: molecular_function
def:
  "Functions to control the survival, growth, differentiation and effector function of tissues and cells." [ISBN:0198599471]


id: GO:0005127
name: ciliary neurotrophic factor receptor binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with the ciliary neurotrophic factor receptor." [GOC:ai]


id: GO:0005129
name: granulocyte macrophage colony-stimulating factor receptor binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with the granulocyte macrophage colony-stimulating factor receptor." [GOC:ai]


id: GO:0005130
name: granulocyte colony-stimulating factor receptor binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with the granulocyte colony-stimulating factor receptor." [GOC:ai]


id: GO:0005132
name: type I interferon receptor binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with an interferon-type I receptor, a heterodimeric complex composed of an alpha subunit (IFNAR1) and a beta subunit (IFNAR2)." [GOC:ai, GOC:signaling, PMID:17502368]


id: GO:0005157
name: macrophage colony-stimulating factor receptor binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with the macrophage colony-stimulating factor receptor." [GOC:ai]


id: GO:0005160
name: transforming growth factor beta receptor binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with the transforming growth factor beta receptor." [GOC:ai]


id: GO:0005161
name: platelet-derived growth factor receptor binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with the platelet-derived growth factor receptor." [GOC:ai]


id: GO:0005163
name: nerve growth factor receptor binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with the nerve growth factor receptor." [GOC:ai, PMID:15654015]


id: GO:0005172
name: vascular endothelial growth factor receptor binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with any vascular endothelial growth factor receptor." [GOC:ai]


id: GO:0005173
name: stem cell factor receptor binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with the stem cell factor receptor (SCFR), a type III transmembrane kinase receptor." [GOC:jl, PMID:10698217]


id: GO:0005174
name: CD40 receptor binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with CD40, a receptor found on the surface of all B-lymphocytes." [GOC:jl, ISBN:0120781859]


id: GO:0005175
name: CD27 receptor binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with a CD27, a receptor found on the surface of T cells and some B cells and NK cells." [GOC:jl, ISBN:0120781859]


id: GO:0005176
name: ErbB-2 class receptor binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with the protein-tyrosine kinase receptor Neu/ErbB-2/HER2." [GOC:jl]


id: GO:0005179
name: hormone activity
namespace: molecular_function
def:
  "The action characteristic of a hormone, any substance formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells in the same organism, upon which it has a specific regulatory action. The term was originally applied to agents with a stimulatory physiological action in vertebrate animals (as opposed to a chalone, which has a depressant action). Usage is now extended to regulatory compounds in lower animals and plants, and to synthetic substances having comparable effects; all bind receptors and trigger some biological process." [GOC:dph, GOC:mah, ISBN:0198506732]


id: GO:0005183
name: gonadotropin hormone-releasing hormone activity
namespace: molecular_function
def:
  "The action characteristic of gonadotropin hormone-releasing hormone (GnRH), any of a family of decapeptide amide hormones that are released by the hypothalamus in response to neural and/or chemical stimuli. In at least mammals, upon receptor binding, GnRH causes the release of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) by the anterior pituitary." [ISBN:0198506732, PMID:11026571, Wikipedia:Gonadotropin-releasing_hormone]


id: GO:0005184
name: neuropeptide hormone activity
namespace: molecular_function
def:
  "The action characteristic of a neuropeptide hormone, any peptide hormone that acts in the central nervous system. A neuropeptide is any of several types of molecules found in brain tissue, composed of short chains of amino acids; they include endorphins, enkephalins, vasopressin, and others. They are often localized in axon terminals at synapses and are classified as putative neurotransmitters, although some are also hormones." [GOC:mah]


id: GO:0005185
name: neurohypophyseal hormone activity
namespace: molecular_function
def:
  "The action characteristic of a neurohypophyseal hormone, any of a family of structurally and functionally related nonapeptides that are synthesized as part of a larger precursor molecule comprising a signal peptide, the nonapeptide hormone, and a neurophysin." [GOC:mah, PMID:19243634]


id: GO:0005186
name: pheromone activity
namespace: molecular_function
def:
  "The activity of binding to and activating specific cell surface receptors, thereby inducing behavioral, developmental, or physiological response(s) from a responding organism or cell. The substance may be released or retained on the cell surface. Pheromones may serve as a specific attractant, social communicator, or sexual stimulant." [GOC:sgd_curators, ISBN:0198506732]


id: GO:0005194
name: obsolete cell adhesion molecule activity
namespace: molecular_function
def:
  "OBSOLETE. Mediates the adhesion of the cell to other cells or to the extracellular matrix." [ISBN:0198506732]


id: GO:0005198
name: structural molecule activity
namespace: molecular_function
def:
  "The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell." [GOC:mah]


id: GO:0005200
name: structural constituent of cytoskeleton
namespace: molecular_function
def:
  "The action of a molecule that contributes to the structural integrity of a cytoskeletal structure." [GOC:mah]


id: GO:0005201
name: extracellular matrix structural constituent
namespace: molecular_function
def:
  "The action of a molecule that contributes to the structural integrity of the extracellular matrix." [GOC:mah]


id: GO:0005212
name: structural constituent of eye lens
namespace: molecular_function
def:
  "The action of a molecule that contributes to the structural integrity of the lens of an eye." [GOC:mah]


id: GO:0005213
name: structural constituent of chorion
namespace: molecular_function
def:
  "The action of a molecule that contributes to the structural integrity of a chorion. An example of this is found in Drosophila melanogaster." [GOC:mah, GOC:sensu]


id: GO:0005214
name: structural constituent of chitin-based cuticle
namespace: molecular_function
def:
  "The action of a molecule that contributes to the structural integrity of a chitin-based cuticle. An example of this is found in Drosophila melanogaster." [GOC:mah, GOC:mtg_sensu]


id: GO:0005215
name: transporter activity
namespace: molecular_function
def:
  "Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf]


id: GO:0005216
name: ion channel activity
namespace: molecular_function
def:
  "Enables the facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. May be either selective (it enables passage of a specific ion only) or non-selective (it enables passage of two or more ions of same charge but different size)." [GOC:cy, GOC:mtg_transport, GOC:pr, ISBN:0815340729]


id: GO:0005217
name: intracellular ligand-gated ion channel activity
namespace: molecular_function
def:
  "Enables the transmembrane transfer of an ion by a channel that opens when a specific intracellular ligand has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729]


id: GO:0005219
name: ryanodine-sensitive calcium-release channel activity
namespace: molecular_function
def:
  "Enables the transmembrane transfer of a calcium ion by a channel that opens when a ryanodine class ligand has been bound by the channel complex or one of its constituent parts." [GOC:dph, GOC:tb]


id: GO:0005220
name: inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity
namespace: molecular_function
def:
  "Enables the transmembrane transfer of a calcium ion by a channel that opens when inositol 1,4,5-trisphosphate (IP3) has been bound by the channel complex or one of its constituent parts." [GOC:mah, GOC:signaling, PMID:8660280, Wikipedia:Inositol_trisphosphate_receptor]


id: GO:0005221
name: intracellular cyclic nucleotide activated cation channel activity
namespace: molecular_function
def:
  "Enables the transmembrane transfer of a cation by a channel that opens when intracellular cyclic nucleotide has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport]


id: GO:0005222
name: intracellular cAMP activated cation channel activity
namespace: molecular_function
def:
  "Enables the transmembrane transfer of a cation by a channel that opens when intracellular cAMP has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport]


id: GO:0005223
name: intracellular cGMP activated cation channel activity
namespace: molecular_function
def:
  "Enables the transmembrane transfer of a cation by a channel that opens when intracellular cGMP has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport]


id: GO:0005224
name: ATP-binding and phosphorylation-dependent chloride channel activity
namespace: molecular_function
def:
  "Enables the transmembrane transfer of a chloride ion by a channel that opens when ATP has been bound by the channel complex or one of its constituent parts." [GOC:mah]


id: GO:0005225
name: volume-sensitive anion channel activity
namespace: molecular_function
def:
  "Enables the transmembrane transfer of an anion by a volume-sensitive channel. An anion is a negatively charged ion. A volume-sensitive channel is a channel that responds to changes in the volume of a cell." [GOC:dph, GOC:tb]


id: GO:0005227
name: calcium activated cation channel activity
namespace: molecular_function
def:
  "Enables the calcium concentration-regulatable energy-independent passage of cations across a lipid bilayer down a concentration gradient." [GOC:dph, GOC:mtg_transport]


id: GO:0005228
name: intracellular sodium activated potassium channel activity
namespace: molecular_function
def:
  "Enables the transmembrane transfer of potassium by a channel that opens in response to stimulus by a sodium ion or ions. Transport by a channel involves facilitated diffusion of a solute (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel, without evidence for a carrier-mediated mechanism. Sodium activated potassium channels have distinctive properties, including a large single channel conductance, subconductance states, and a block of single channel currents at positive potentials, similar to inward rectification." [GOC:mtg_transport, PMID:12628167]


id: GO:0005229
name: intracellular calcium activated chloride channel activity
namespace: molecular_function
def:
  "Enables the transmembrane transfer of chloride by a channel that opens in response to stimulus by a calcium ion or ions. Transport by a channel involves catalysis of facilitated diffusion of a solute (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel, without evidence for a carrier-mediated mechanism." [GOC:mtg_transport]


id: GO:0005230
name: extracellular ligand-gated ion channel activity
namespace: molecular_function
def:
  "Enables the transmembrane transfer of an ion by a channel that opens when a specific extracellular ligand has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729]


id: GO:0005231
name: excitatory extracellular ligand-gated ion channel activity
namespace: molecular_function
def:
  "Enables the transmembrane transfer of an ion by a channel that opens when a specific extracellular excitatory ligand has been bound by the channel complex or one of its constituent parts. Excitatory ligands, such as acetylcholine or glutamate, open cation-selective channels." [GOC:mah, ISBN:0323037070]


id: GO:0005232
name: serotonin-activated cation-selective channel activity
namespace: molecular_function
def:
  "Enables the transmembrane transfer of a cation by a channel that opens when a specific extracellular ligand has been bound by the channel complex or one of its constituent parts, and that is activated by serotonin." [GOC:mah]


id: GO:0005234
name: extracellular-glutamate-gated ion channel activity
namespace: molecular_function
def:
  "Enables the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729]


id: GO:0005237
name: inhibitory extracellular ligand-gated ion channel activity
namespace: molecular_function
def:
  "Enables the transmembrane transfer of an ion by a channel that opens when a specific extracellular inhibitory ligand has been bound by the channel complex or one of its constituent parts. Inhibitory ligands, such as GABA or glycine, open chloride-selective channels." [GOC:mah, ISBN:0323037070]


id: GO:0005242
name: inward rectifier potassium channel activity
namespace: molecular_function
def:
  "Enables the transmembrane transfer of a potassium ion by an inwardly-rectifying voltage-gated channel. An inwardly rectifying current-voltage relation is one where at any given driving force the inward flow of K+ ions exceeds the outward flow for the opposite driving force. The inward-rectification is due to a voltage-dependent block of the channel pore by a specific ligand or ligands, and as a result the macroscopic conductance depends on the difference between membrane voltage and the K+ equilibrium potential rather than on membrane voltage itself." [GOC:cb, GOC:mah, PMID:14977398]


id: GO:0005243
name: gap junction channel activity
namespace: molecular_function
def:
  "A wide pore channel activity that enables a direct cytoplasmic connection from one cell to an adjacent cell. The gap junction can pass large solutes as well as electrical signals between cells. Gap junctions consist of two gap junction hemi-channels, or connexons, one contributed by each membrane through which the gap junction passes." [GOC:dgh, GOC:mtg_transport, ISBN:0815340729]


id: GO:0005244
name: voltage-gated ion channel activity
namespace: molecular_function
def:
  "Enables the transmembrane transfer of an ion by a voltage-gated channel. An ion is an atom or group of atoms carrying an electric charge by virtue of having gained or lost one or more electrons. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:mtg_transport, ISBN:0198506732, ISBN:0815340729]


id: GO:0005245
name: voltage-gated calcium channel activity
namespace: molecular_function
def:
  "Enables the transmembrane transfer of a calcium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:mtg_transport, GOC:tb, ISBN:0815340729]


id: GO:0005247
name: voltage-gated chloride channel activity
namespace: molecular_function
def:
  "Enables the transmembrane transfer of a chloride ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:mtg_transport, ISBN:0815340729]


id: GO:0005248
name: voltage-gated sodium channel activity
namespace: molecular_function
def:
  "Enables the transmembrane transfer of a sodium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:mtg_transport, ISBN:0815340729]


id: GO:0005249
name: voltage-gated potassium channel activity
namespace: molecular_function
def:
  "Enables the transmembrane transfer of a potassium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:mtg_transport, ISBN:0815340729]


id: GO:0005250
name: A-type (transient outward) potassium channel activity
namespace: molecular_function
def:
  "Enables the transmembrane transfer of a potassium ion by an outwardly-rectifying voltage-gated channel that produces a transient outward current upon a step change in membrane potential." [GOC:mah, PMID:5575340]


id: GO:0005251
name: delayed rectifier potassium channel activity
namespace: molecular_function
def:
  "Enables the transmembrane transfer of a potassium ion by a delayed rectifying voltage-gated channel. A delayed rectifying current-voltage relation is one where channel activation kinetics are time-dependent, and inactivation is slow." [GOC:mah, PMID:11343411, PMID:2462513]


id: GO:0005252
name: open rectifier potassium channel activity
namespace: molecular_function
def:
  "Enables the transmembrane transfer of a potassium ion by an open rectifier voltage-gated channel. An open rectifier current-voltage relationship is one in which the direction of rectification depends on the external potassium ion concentration." [GOC:mah, PMID:8917578]


id: GO:0005253
name: anion channel activity
namespace: molecular_function
def:
  "Enables the energy-independent passage of anions across a lipid bilayer down a concentration gradient." [GOC:dph, GOC:mtg_transport, GOC:pr, ISBN:0815340729]


id: GO:0005254
name: chloride channel activity
namespace: molecular_function
def:
  "Enables the facilitated diffusion of a chloride (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:mtg_transport, GOC:pr, ISBN:0815340729]


id: GO:0005260
name: channel-conductance-controlling ATPase activity
namespace: molecular_function
def:
  "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate. An animal enzyme that is active in forming a chloride channel, the absence of which brings about cystic fibrosis. It is also involved in the functioning of other transmembrane channels." [EC:3.6.3.49]


id: GO:0005261
name: cation channel activity
namespace: molecular_function
def:
  "Enables the energy-independent passage of cations across a lipid bilayer down a concentration gradient." [GOC:def, GOC:dph, GOC:mtg_transport, GOC:pr, ISBN:0815340729]


id: GO:0005262
name: calcium channel activity
namespace: molecular_function
def:
  "Enables the facilitated diffusion of a calcium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:mtg_transport, GOC:pr, ISBN:0815340729]


id: GO:0005267
name: potassium channel activity
namespace: molecular_function
def:
  "Enables the facilitated diffusion of a potassium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:BHF, GOC:mtg_transport, GOC:pr, ISBN:0815340729]


id: GO:0005272
name: sodium channel activity
namespace: molecular_function
def:
  "Enables the facilitated diffusion of a sodium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:BHF, GOC:mtg_transport, GOC:pr, ISBN:0815340729]


id: GO:0005274
name: allantoin uptake transmembrane transporter activity
namespace: molecular_function
def:
  "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: allantoin(out) + H+(out) = allantoin(in) + H+(in) by secondary active transport." [GOC:mtg_transport, ISBN:0815340729, TC:2.A.39.3.1]


id: GO:0005275
name: amine transmembrane transporter activity
namespace: molecular_function
def:
  "Enables the transfer of amines, including polyamines, from one side of the membrane to the other. Amines are organic compounds that are weakly basic in character and contain an amino (-NH2) or substituted amino group." [GOC:mtg_transport, ISBN:0198506732, ISBN:0815340729]


id: GO:0005276
name: vesicular hydrogen:amino acid antiporter activity
namespace: molecular_function
def:
  "Catalysis of the transfer of a solute or solutes from one side of a vesicle membrane to the other according to the reaction: H+(in) + amino acid(out) = H+(out) + amino acid(in)." [GOC:mah, Reactome:428625]


id: GO:0005277
name: acetylcholine transmembrane transporter activity
namespace: molecular_function
def:
  "Enables the transfer of acetylcholine from one side of the membrane to the other. Acetylcholine is an acetic acid ester of the organic base choline and functions as a neurotransmitter, released at the synapses of parasympathetic nerves and at neuromuscular junctions." [GOC:ai]


id: GO:0005278
name: acetylcholine:proton antiporter activity
namespace: molecular_function
def:
  "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + acetylcholine(in) = H+(in) + acetylcholine(out)." [TC:2.A.1.2.13]


id: GO:0005280
name: hydrogen:amino acid symporter activity
namespace: molecular_function
def:
  "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: amino acid(out) + H+(out) = amino acid(in) + H+(in)." [GOC:ai]


id: GO:0005283
name: sodium:amino acid symporter activity
namespace: molecular_function
def:
  "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: amino acid(out) + Na+(out) = amino acid(in) + Na+(in)." [GOC:ai]


id: GO:0005287
name: high-affinity basic amino acid transmembrane transporter activity
namespace: molecular_function
def:
  "Catalysis of the transfer of basic amino acids from one side of a membrane to the other. Acidic amino acids have a pH above 7. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations." [GOC:mtg_transport]


id: GO:0005289
name: high-affinity arginine transmembrane transporter activity
namespace: molecular_function
def:
  "Catalysis of the transfer of arginine from one side of a membrane to the other. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations." [GOC:mtg_transport]


id: GO:0005290
name: L-histidine transmembrane transporter activity
namespace: molecular_function
def:
  "Enables the transfer of L-histidine from one side of a membrane to the other. L-histidine is 2-amino-3-(1H-imidazol-4-yl)propanoic acid." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]


id: GO:0005291
name: high-affinity L-histidine transmembrane transporter activity
namespace: molecular_function
def:
  "Catalysis of the transfer of L-histidine from one side of a membrane to the other. L-histidine is 2-amino-3-(1H-imidazol-4-yl)propanoic acid. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations." [GOC:mtg_transport]


id: GO:0005292
name: high-affinity lysine transmembrane transporter activity
namespace: molecular_function
def:
  "Catalysis of the transfer of lysine from one side of a membrane to the other. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations." [GOC:mtg_transport]


id: GO:0005294
name: neutral L-amino acid secondary active transmembrane transporter activity
namespace: molecular_function
def:
  "Catalysis of the transfer of a neutral L-amino acid from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport." [GOC:mtg_transport]


id: GO:0005295
name: neutral amino acid:sodium symporter activity
namespace: molecular_function
def:
  "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: neutral amino acid(out) + Na+(out) = neutral amino acid(in) + Na+(in)." [TC:2.A.23.3.1]


id: GO:0005297
name: hydrogen:proline symporter activity
namespace: molecular_function
def:
  "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: proline(out) + H+(out) = proline(in) + H+(in)." [GOC:ai]


id: GO:0005298
name: proline:sodium symporter activity
namespace: molecular_function
def:
  "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: proline(out) + Na+(out) = proline(in) + Na+(in)." [TC:2.A.22.2.1]


id: GO:0005300
name: high-affinity tryptophan transmembrane transporter activity
namespace: molecular_function
def:
  "Catalysis of the high-affinity transfer of L-tryptophan from one side of a membrane to the other. Tryptophan is 2-amino-3-(1H-indol-3-yl)propanoic acid. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations." [GOC:mtg_transport, ISBN:0815340729]


id: GO:0005302
name: L-tyrosine transmembrane transporter activity
namespace: molecular_function
def:
  "Enables the transfer of L-tyrosine from one side of a membrane to the other. L-tyrosine is 2-amino-3-(4-hydroxyphenyl)propanoic acid." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]


id: GO:0005304
name: L-valine transmembrane transporter activity
namespace: molecular_function
def:
  "Enables the transfer of L-valine from one side of a membrane to the other. L-valine is 2-amino-3-methylbutanoic acid." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]


id: GO:0005307
name: choline:sodium symporter activity
namespace: molecular_function
def:
  "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: choline(out) + Na+(out) = choline(in) + Na+(in)." [TC:2.A.22.3.5]


id: GO:0005308
name: creatine transmembrane transporter activity
namespace: molecular_function
def:
  "Enables the directed movement of creatine across a membrane. Creatine is a compound synthesized from the amino acids arginine, glycine, and methionine that occurs in muscle." [GOC:ai]


id: GO:0005309
name: creatine:sodium symporter activity
namespace: molecular_function
def:
  "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: creatine(out) + Na+(out) = creatine(in) + Na+(in)." [TC:2.A.22.3.4]


id: GO:0005310
name: dicarboxylic acid transmembrane transporter activity
namespace: molecular_function
def:
  "Enables the transfer of dicarboxylic acids from one side of the membrane to the other. A dicarboxylic acid is an organic acid with two COOH groups." [GOC:ai]


id: GO:0005311
name: obsolete sodium:dicarboxylate/tricarboxylate symporter activity
namespace: molecular_function
def:
  "OBSOLETE. Catalysis of the reaction: (dicarboxylate or tricarboxylate)(out) + Na+(out) = (dicarboxylate or tricarboxylate)(in) + Na+(in)." [TC:2.A.47.1.5]


id: GO:0005313
name: L-glutamate transmembrane transporter activity
namespace: molecular_function
def:
  "Enables the transfer of L-glutamate from one side of a membrane to the other. L-glutamate is the anion of 2-aminopentanedioic acid." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]


id: GO:0005314
name: high-affinity glutamate transmembrane transporter activity
namespace: molecular_function
def:
  "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glutamate(out) + H+(out) = glutamate(in) + H+(in). In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations." [TC:2.A.3.10.5]


id: GO:0005315
name: inorganic phosphate transmembrane transporter activity
namespace: molecular_function
def:
  "Enables the transfer of a inorganic phosphate from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport." [GOC:mtg_transport]


id: GO:0005316
name: high-affinity inorganic phosphate:sodium symporter activity
namespace: molecular_function
def:
  "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: HPO42-(out) + Na+(out) = HPO42-(in) + Na+(in). In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations." [TC:2.A.20.2.2]


id: GO:0005324
name: long-chain fatty acid transporter activity
namespace: molecular_function
def:
  "Enables the directed movement of long-chain fatty acids into, out of or within a cell, or between cells. A long-chain fatty acid is a fatty acid with a chain length between C13 and C22." [CHEBI:15904, ISBN:0198506732]


id: GO:0005325
name: peroxisomal fatty-acyl-CoA transporter activity
namespace: molecular_function
def:
  "Catalysis of the reaction: ATP + H2O + fatty acyl CoA(cis) = ADP + phosphate + fatty acyl CoA(trans). The transport of fatty acyl CoA into and out of peroxisomes." [EC:3.6.3.47]


id: GO:0005326
name: neurotransmitter transporter activity
namespace: molecular_function
def:
  "Enables the directed movement of a neurotransmitter into, out of or within a cell, or between cells. Neurotransmitters are any chemical substance that is capable of transmitting (or inhibiting the transmission of) a nerve impulse from a neuron to another cell." [GOC:ai, ISBN:0198506732]


id: GO:0005328
name: neurotransmitter:sodium symporter activity
namespace: molecular_function
def:
  "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: neurotransmitter(out) + Na+(out) = neurotransmitter(in) + Na+(in)." [TC:2.A.22.-.-]


id: GO:0005329
name: dopamine transmembrane transporter activity
namespace: molecular_function
def:
  "Enables the transfer of dopamine from one side of the membrane to the other. Dopamine is a catecholamine neurotransmitter and a metabolic precursor of noradrenaline and adrenaline." [GOC:ai]


id: GO:0005330
name: dopamine:sodium symporter activity
namespace: molecular_function
def:
  "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dopamine(out) + Na+(out) = dopamine(in) + Na+(in)." [TC:2.A.22.1.3]


id: GO:0005332
name: gamma-aminobutyric acid:sodium symporter activity
namespace: molecular_function
def:
  "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: gamma-aminobutyric acid(out) + Na+(out) = gamma-aminobutyric acid(in) + Na+(in)." [TC:2.A.22.3.2]


id: GO:0005333
name: norepinephrine transmembrane transporter activity
namespace: molecular_function
def:
  "Enables the transfer of norepinephrine from one side of the membrane to the other. Norepinephrine (3,4-dihydroxyphenyl-2-aminoethanol) is a hormone secreted by the adrenal medulla and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts of the CNS. It is also the biosynthetic precursor of epinephrine." [ISBN:0198506732]


id: GO:0005334
name: norepinephrine:sodium symporter activity
namespace: molecular_function
def:
  "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: norepinephrine(out) + Na+(out) = norepinephrine(in) + Na+(in)." [TC:2.A.22.1.2]


id: GO:0005335
name: serotonin:sodium symporter activity
namespace: molecular_function
def:
  "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: serotonin(out) + Na+(out) = serotonin(in) + Na+(in)." [TC:2.A.22.1.1]


id: GO:0005337
name: nucleoside transmembrane transporter activity
namespace: molecular_function
def:
  "Enables the transfer of a nucleoside, a nucleobase linked to either beta-D-ribofuranose (ribonucleoside) or 2-deoxy-beta-D-ribofuranose, (a deoxyribonucleotide) from one side of a membrane to the other." [GOC:ai]


id: GO:0005338
name: nucleotide-sugar transmembrane transporter activity
namespace: molecular_function
def:
  "Enables the transfer of a nucleotide-sugar from one side of the membrane to the other. A nucleotide-sugar is any nucleotide in which the distal phosphoric residue of a nucleoside 5'-diphosphate is in glycosidic linkage with a monosaccharide or monosaccharide derivative." [GOC:ai, GOC:mtg_transport, ISBN:0815340729, PMID:15034926]


id: GO:0005340
name: nucleotide-sulfate transmembrane transporter activity
namespace: molecular_function
def:
  "Enables the transfer of nucleotide-sulfate from one side of a membrane to the other." [GOC:mtg_transport]


id: GO:0005342
name: organic acid transmembrane transporter activity
namespace: molecular_function
def:
  "Enables the transfer of organic acids, any acidic compound containing carbon in covalent linkage, from one side of the membrane to the other." [ISBN:0198506732]


id: GO:0005343
name: organic acid:sodium symporter activity
namespace: molecular_function
def:
  "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: organic acid(out) + Na+(out) = organic acid(in) + Na+(in)." [TC:2.A.28.1.1]


id: GO:0005345
name: purine nucleobase transmembrane transporter activity
namespace: molecular_function
def:
  "Enables the transfer of purine nucleobases, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, from one side of a membrane to the other." [CHEBI:26386, ISBN:0198506732]


id: GO:0005346
name: purine ribonucleotide transmembrane transporter activity
namespace: molecular_function
def:
  "Enables the transfer of a purine ribonucleotide, any compound consisting of a purine ribonucleoside (a purine organic base attached to a ribose sugar) esterified with (ortho)phosphate, from one side of a membrane to the other." [GOC:ai]


id: GO:0005347
name: ATP transmembrane transporter activity
namespace: molecular_function
def:
  "Enables the transfer of ATP, adenosine triphosphate, from one side of a membrane to the other." [GOC:ai]


id: GO:0005350
name: pyrimidine nucleobase transmembrane transporter activity
namespace: molecular_function
def:
  "Enables the transfer of pyrimidine nucleobases, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, from one side of a membrane to the other." [CHEBI:26432, GOC:ai]


id: GO:0005351
name: sugar:proton symporter activity
namespace: molecular_function
def:
  "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sugar(out) + H+(out) = sugar(in) + H+(in)." [TC:2.A.1.1.-]


id: GO:0005352
name: alpha-glucoside:proton symporter activity
namespace: molecular_function
def:
  "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: alpha-glucoside(out) + H+(out) = alpha-glucoside(in) + H+(in). Alpha-glucosides include trehalose, maltose, turanose, isomaltose, alpha-methylglucoside, maltotriose, palatinose, trehalose and melezitose." [TC:2.A.1.1.11]


id: GO:0005353
name: fructose transmembrane transporter activity
namespace: molecular_function
def:
  "Enables the transfer of fructose from one side of the membrane to the other. Fructose exists in a open chain form or as a ring compound. D-fructose is the sweetest of the sugars and is found free in a large number of fruits and honey." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]


id: GO:0005354
name: galactose transmembrane transporter activity
namespace: molecular_function
def:
  "Enables the transfer of galactose from one side of the membrane to the other. D-galactose is widely distributed in combined form in plants, animals and microorganisms as a constituent of oligo- and polysaccharides; it also occurs in galactolipids and as its glucoside in lactose and melibiose." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]


id: GO:0005355
name: glucose transmembrane transporter activity
namespace: molecular_function
def:
  "Enables the transfer of the hexose monosaccharide glucose from one side of the membrane to the other." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]


id: GO:0005356
name: hydrogen:glucose symporter activity
namespace: molecular_function
def:
  "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glucose + H+ = glucose + H+. Symporter activity enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy." [GOC:mtg_transport]


id: GO:0005357
name: constitutive hydrogen:glucose symporter activity
namespace: molecular_function
def:
  "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glucose + H+ = glucose + H+. This activity is constitutive and therefore always present, regardless of demand. Symporter activity enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy." [GOC:mtg_transport]


id: GO:0005358
name: high-affinity hydrogen:glucose symporter activity
namespace: molecular_function
def:
  "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glucose + H+ = glucose + H+. This activity is constitutive and therefore always present, regardless of demand. Symporter activity enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations." [GOC:mtg_transport]


id: GO:0005359
name: low-affinity hydrogen:glucose symporter activity
namespace: molecular_function
def:
  "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glucose + H+ = glucose + H+. In low-affinity transport the transporter is able to bind the solute only if it is present at very high concentrations. Symporter activity enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy." [GOC:mtg_transport]


id: GO:0005360
name: insulin-responsive hydrogen:glucose symporter activity
namespace: molecular_function
def:
  "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glucose + H+ = glucose + H+, in response to a stimulus by insulin. Symporter activity enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy." [GOC:mtg_transport]


id: GO:0005362
name: low-affinity glucose:sodium symporter activity
namespace: molecular_function
def:
  "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glucose(out) + Na+(out) = glucose(in) + Na+(in). In low-affinity transport the transporter is able to bind the solute only if it is present at very high concentrations." [TC:2.A.21.3.-]


id: GO:0005363
name: maltose transmembrane transporter activity
namespace: molecular_function
def:
  "Enables the transfer of maltose from one side of the membrane to the other. Maltose is the disaccharide 4-O-alpha-D-glucopyranosyl-D-glucopyranose, an intermediate in the enzymatic breakdown of glycogen and starch." [GOC:mtg_transport, ISBN:0198506732, ISBN:0815340729]


id: GO:0005364
name: maltose:proton symporter activity
namespace: molecular_function
def:
  "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: maltose(out) + H+(out) = maltose(in) + H+(in)." [TC:2.A.1.1.10]


id: GO:0005365
name: myo-inositol transmembrane transporter activity
namespace: molecular_function
def:
  "Enables the transfer of myo-inositol from one side of the membrane to the other. Myo-inositol is 1,2,3,4,5/4,6-cyclohexanehexol, a growth factor for animals and microorganisms." [GOC:ai]


id: GO:0005366
name: myo-inositol:proton symporter activity
namespace: molecular_function
def:
  "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: myo-inositol(out) + H+(out) = myo-inositol(in) + H+(in)." [TC:2.A.1.1.8]


id: GO:0005367
name: myo-inositol:sodium symporter activity
namespace: molecular_function
def:
  "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: myo-inositol(out) + Na+(out) = myo-inositol(in) + Na+(in)." [TC:2.A.21.4.-]


id: GO:0005368
name: taurine transmembrane transporter activity
namespace: molecular_function
def:
  "Enables the transfer of taurine from one side of the membrane to the other. Taurine (2-aminoethanesulfonic acid) is a sulphur-containing amino acid derivative which is important in the metabolism of fats." [GOC:ai]


id: GO:0005369
name: taurine:sodium symporter activity
namespace: molecular_function
def:
  "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: taurine(out) + Na+(out) = taurine(in) + Na+(in)." [TC:2.A.22.3.3]


id: GO:0005371
name: tricarboxylate secondary active transmembrane transporter activity
namespace: molecular_function
def:
  "Catalysis of the transfer of tricarboxylate from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport." [GOC:mtg_transport, ISBN:0815340729]


id: GO:0005373
name: obsolete heavy metal ion porter activity
namespace: molecular_function
def:
  "OBSOLETE. A transporter of heavy metal ions that utilizes a carrier-mediated process to catalyze uniport, symport or antiport between aqueous phases on either side of a lipid membrane." [GOC:ai]


id: GO:0005384
name: manganese ion transmembrane transporter activity
namespace: molecular_function
def:
  "Catalysis of the transfer of manganese (Mn) ions from one side of a membrane to the other." [GOC:dgf]


id: GO:0005388
name: calcium-transporting ATPase activity
namespace: molecular_function
def:
  "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Ca2+(cis) = ADP + phosphate + Ca2+(trans)." [EC:3.6.3.8]


id: GO:0005391
name: sodium:potassium-exchanging ATPase activity
namespace: molecular_function
def:
  "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Na+(in) + K+(out) = ADP + phosphate + Na+(out) + K+(in)." [EC:3.6.3.9]


id: GO:0005395
name: eye pigment precursor transporter activity
namespace: molecular_function
def:
  "Catalysis of the reaction: ATP + H2O + eye pigment precursor(in) = ADP + phosphate + eye pigment precursor(out)." [TC:3.A.1.204.1]


id: GO:0005402
name: cation:sugar symporter activity
namespace: molecular_function
def:
  "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sugar(out) + cation(out) = sugar(in) + cation(in)." [GOC:ai]


id: GO:0005412
name: glucose:sodium symporter activity
namespace: molecular_function
def:
  "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glucose(out) + Na+(out) = glucose(in) + Na+(in)." [TC:2.A.21.3.-]


id: GO:0005415
name: nucleoside:sodium symporter activity
namespace: molecular_function
def:
  "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: nucleoside(out) + Na+(out) = nucleoside(in) + Na+(in)." [GOC:ai]


id: GO:0005416
name: cation:amino acid symporter activity
namespace: molecular_function
def:
  "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: amino acid(out) + cation(out) = amino acid(in) + cation(in)." [GOC:ai]


id: GO:0005427
name: proton-dependent oligopeptide secondary active transmembrane transporter activity
namespace: molecular_function
def:
  "Catalysis of the transfer of a oligopeptide from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by proton movement." [GOC:mtg_transport, OMIM:600544]


id: GO:0005432
name: calcium:sodium antiporter activity
namespace: molecular_function
def:
  "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Ca2+(in) + Na+(out) = Ca2+(out) + Na+(in)." [GOC:curators, PMID:16371597]


id: GO:0005436
name: sodium:phosphate symporter activity
namespace: molecular_function
def:
  "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + phosphate(out) = Na+(in) + phosphate(in)." [GOC:ai]


id: GO:0005451
name: monovalent cation:proton antiporter activity
namespace: molecular_function
def:
  "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: monovalent cation(out) + H+(in) = monovalent cation(in) + H+(out)." [GOC:ai]


id: GO:0005452
name: inorganic anion exchanger activity
namespace: molecular_function
def:
  "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: inorganic anion A(out) + inorganic anion B(in) = inorganic anion A(in) + inorganic anion B(out)." [GOC:mah]


id: GO:0005456
name: CMP-N-acetylneuraminate transmembrane transporter activity
namespace: molecular_function
def:
  "Enables the transfer of a CMP-N-acetylneuraminate from one side of the membrane to the other." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]


id: GO:0005457
name: GDP-fucose transmembrane transporter activity
namespace: molecular_function
def:
  "Enables the transfer of a GDP-fucose from one side of the membrane to the other. GDP-fucose is a substance composed of fucose in glycosidic linkage with guanosine diphosphate." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]


id: GO:0005458
name: GDP-mannose transmembrane transporter activity
namespace: molecular_function
def:
  "Enables the transfer of a GDP-mannose from one side of the membrane to the other. GDP-mannose is a substance composed of mannose in glycosidic linkage with guanosine diphosphate." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]


id: GO:0005459
name: UDP-galactose transmembrane transporter activity
namespace: molecular_function
def:
  "Catalysis of the transfer of a UDP-galactose from one side of the membrane to the other. UDP-galactose is a substance composed of galactose in glycosidic linkage with uridine diphosphate." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]


id: GO:0005460
name: UDP-glucose transmembrane transporter activity
namespace: molecular_function
def:
  "Enables the transfer of a UDP-glucose from one side of the membrane to the other. UDP-glucose is a substance composed of glucose in glycosidic linkage with uridine diphosphate." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]


id: GO:0005461
name: UDP-glucuronic acid transmembrane transporter activity
namespace: molecular_function
def:
  "Catalysis of the transfer of a UDP-glucuronic acid from one side of the membrane to the other. UDP-glucuronic acid is a substance composed of glucuronic acid in glycosidic linkage with uridine diphosphate." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]


id: GO:0005462
name: UDP-N-acetylglucosamine transmembrane transporter activity
namespace: molecular_function
def:
  "Enables the transfer of a UDP-N-acetylglucosamine from one side of the membrane to the other. N-acetylglucosamine is a substance composed of N-acetylglucosamine, a common structural unit of oligosaccharides, in glycosidic linkage with uridine diphosphate." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]


id: GO:0005463
name: UDP-N-acetylgalactosamine transmembrane transporter activity
namespace: molecular_function
def:
  "Catalysis of the transfer of a N-acetylgalactosamine from one side of the membrane to the other. N-acetylgalactosamine is a substance composed of N-acetylgalactosamine, a common structural unit of oligosaccharides, in glycosidic linkage with uridine diphosphate." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]


id: GO:0005464
name: UDP-xylose transmembrane transporter activity
namespace: molecular_function
def:
  "Enables the transfer of UDP-xylose from one side of the membrane to the other. UDP-xylose is a substance composed of xylose in glycosidic linkage with uridine diphosphate." [GOC:ai]


id: GO:0005469
name: succinate:fumarate antiporter activity
namespace: molecular_function
def:
  "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: succinate(out) + fumarate(in) = succinate(in) + fumarate(out)." [TC:2.A.29.13.1]


id: GO:0005472
name: FAD carrier activity
namespace: molecular_function
def:
  "Catalysis of the transfer of flavin adenine dinucleotide from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport." [GOC:mah]


id: GO:0005476
name: carnitine:acyl carnitine antiporter activity
namespace: molecular_function
def:
  "Catalysis of the reaction: carnitine (mitochondrial) + acyl carnitine (cytoplasm) = carnitine (cytoplasm) + acyl carnitine (mitochondrial)." [PMID:9032458]


id: GO:0005477
name: pyruvate secondary active transmembrane transporter activity
namespace: molecular_function
def:
  "Catalysis of the transfer of pyruvate from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport." [GOC:mtg_transport]


id: GO:0005483
name: soluble NSF attachment protein activity
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with both N-ethylmaleimide-sensitive fusion protein (NSF) and a cis-SNARE complex (i.e. a SNARE complex in which all proteins are associated with the same membrane) and increasing the ATPase activity of NSF, thereby allowing ATP hydrolysis by NSF to disassemble the cis-SNARE complex." [GOC:mah, PMID:14570579, PMID:15556857]


id: GO:0005484
name: SNAP receptor activity
namespace: molecular_function
def:
  "Acting as a marker to identify a membrane and interacting selectively with one or more SNAREs on another membrane to mediate membrane fusion." [GOC:mah, PMID:14570579]


id: GO:0005487
name: nucleocytoplasmic transporter activity
namespace: molecular_function
def:
  "Enables the directed movement of substances between the nucleus and the cytoplasm of a cell." [GOC:ai]


id: GO:0005488
name: binding
namespace: molecular_function
def:
  "The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732]


id: GO:0005489
name: obsolete electron transporter activity
namespace: molecular_function
def:
  "OBSOLETE. Enables the directed movement of electrons into, out of, within or between cells." [GOC:ai]


id: GO:0005490
name: obsolete cytochrome P450
namespace: molecular_function
def:
  "OBSOLETE. A cytochrome b that has a sulfur atom ligated to the iron of the prosthetic group (heme-thiolate); enzymes:typically monooxygenases acting on lipophilic substrates." [ISBN:0198547684]


id: GO:0005496
name: steroid binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with a steroid, any of a large group of substances that have in common a ring system based on 1,2-cyclopentanoperhydrophenanthrene." [GOC:jl, ISBN:0198506732]


id: GO:0005497
name: androgen binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with any androgen, male sex hormones." [CHEBI:50113, GOC:jl]


id: GO:0005499
name: vitamin D binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with vitamin D, any of a group of related, fat-soluble compounds that are derived from delta-5,7 steroids and play a central role in calcium metabolism. Specific forms of vitamin D include calciferol (ergocalciferol; vitamin D2) and cholecalciferol (calciol; vitamin D3)." [CHEBI:27300, GOC:mah, ISBN:0471331309]


id: GO:0005500
name: juvenile hormone binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with juvenile hormone, the three sesquiterpenoid derivatives that function to maintain the larval state of insects at molting and that may be required for other processes, e.g. oogenesis." [GOC:jl, ISBN:0198506732]


id: GO:0005501
name: retinoid binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with retinoids, any member of a class of isoprenoids that contain or are derived from four prenyl groups linked head-to-tail. Retinoids include retinol and retinal and structurally similar natural derivatives or synthetic compounds, but need not have vitamin A activity." [GOC:jl, ISBN:0198506732]


id: GO:0005502
name: 11-cis retinal binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with 11-cis retinal, an isomer of retinal that plays an important role in the visual process in most vertebrates. 11-cis retinal combines with opsin in the rods (scotopsin) to form rhodopsin or visual purple. Retinal is one of the three compounds that makes up vitamin A." [CHEBI:16066]


id: GO:0005503
name: all-trans retinal binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with all-trans retinal, a compound that plays an important role in the visual process in most vertebrates. All-trans retinal (trans r., visual yellow) results from the bleaching of rhodopsin by light, in which the 11-cis form is converted to the all-trans form. Retinal is one of the forms of vitamin A." [CHEBI:17898, GOC:curators]


id: GO:0005504
name: fatty acid binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis." [ISBN:0198506732]


id: GO:0005505
name: obsolete heavy metal binding
namespace: molecular_function
def:
  "OBSOLETE. Interacting selectively with a heavy metal, a metal that can form a coordination bond with a protein, as opposed to an alkali or alkaline-earth metal that can only form an ionic bond; this definition includes the following biologically relevant heavy metals: Cd, Co, Cu, Fe, Hg, Mn, Mo, Ni, V, W, Zn." [GOC:kd, GOC:mah]


id: GO:0005513
name: detection of calcium ion
namespace: biological_process
def:
  "The series of events in which a calcium ion stimulus is received by a cell and converted into a molecular signal." [GOC:pg]


id: GO:0005515
name: protein binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators]


id: GO:0005516
name: calmodulin binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states." [GOC:krc]


id: GO:0005518
name: collagen binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with collagen, a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals. Collagen is highly enriched in glycine (some regions are 33% glycine) and proline, occurring predominantly as 3-hydroxyproline (about 20%)." [GOC:ai, ISBN:0198506732]


id: GO:0005519
name: cytoskeletal regulatory protein binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with any protein involved in modulating the reorganization of the cytoskeleton." [GOC:go_curators, PMID:15163540]


id: GO:0005520
name: insulin-like growth factor binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with an insulin-like growth factor, any member of a group of polypeptides that are structurally homologous to insulin and share many of its biological activities, but are immunologically distinct from it." [ISBN:0198506732]


id: GO:0005521
name: lamin binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with lamin; any of a group of intermediate-filament proteins that form the fibrous matrix on the inner surface of the nuclear envelope." [GOC:jl, ISBN:0198506732]


id: GO:0005522
name: profilin binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with profilin, an actin-binding protein that forms a complex with G-actin and prevents it from polymerizing to form F-actin." [ISBN:0721662544]


id: GO:0005523
name: tropomyosin binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with tropomyosin, a protein associated with actin filaments both in cytoplasm and, in association with troponin, in the thin filament of striated muscle." [GOC:curators, ISBN:0815316194]


id: GO:0005524
name: ATP binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732]


id: GO:0005527
name: macrolide binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with a macrolide, any of a large group of structurally related antibiotics produced by Streptomyces species." [GOC:jl, ISBN:0198506732]


id: GO:0005530
name: obsolete lectin
namespace: molecular_function
def:
  "OBSOLETE. Lectins are proteins obtained particularly from the seeds of leguminous plants, but also from many other plant and animal sources, that have binding sites for specific mono or oligosaccharides in cell walls or membranes. They thereby change the physiology of the membrane to cause agglutination, mitosis, or other biochemical changes in the cell." [GOC:curators]


id: GO:0005534
name: galactose binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with the aldohexose galactose (galacto-hexose), a common constituent of many oligo- and polysaccharides." [CHEBI:28260, GOC:jl, ISBN:0198506732]


id: GO:0005536
name: glucose binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with the D- or L-enantiomer of glucose." [CHEBI:17234, GOC:jl]


id: GO:0005537
name: mannose binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with mannose, a monosaccharide hexose, stereoisomeric with glucose, that occurs naturally only in polymerized forms called mannans." [CHEBI:37684, GOC:jl, ISBN:0192800981]


id: GO:0005539
name: glycosaminoglycan binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with any glycan (polysaccharide) containing a substantial proportion of aminomonosaccharide residues." [GOC:jl, ISBN:0198506732]


id: GO:0005540
name: hyaluronic acid binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with hyaluronic acid, a polymer composed of repeating dimeric units of glucuronic acid and N-acetyl glucosamine." [CHEBI:16336, GOC:jl]


id: GO:0005541
name: obsolete acyl-CoA or acyl binding
namespace: molecular_function
def:
  "OBSOLETE. Interacting selectively with acyl-CoA or acyl, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with a fatty acyl group, or any group formally derived by removal of a hydroxyl group from the acid function of an organic acid." [GOC:jl, ISBN:0198506732]


id: GO:0005542
name: folic acid binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with folic acid, pteroylglutamic acid. Folic acid is widely distributed as a member of the vitamin B complex and is essential for the synthesis of purine and pyrimidines." [GOC:jl, ISBN:0198506732]


id: GO:0005543
name: phospholipid binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with phospholipids, a class of lipids containing phosphoric acid as a mono- or diester." [ISBN:0198506732]


id: GO:0005544
name: calcium-dependent phospholipid binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with phospholipids, a class of lipids containing phosphoric acid as a mono- or diester, in the presence of calcium." [GOC:jl]


id: GO:0005545
name: 1-phosphatidylinositol binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with phosphatidylinositol, any glycophospholipid with its sn-glycerol 3-phosphate residue is esterified to the 1-hydroxyl group of 1D-myo-inositol." [ISBN:0198506732]


id: GO:0005546
name: phosphatidylinositol-4,5-bisphosphate binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with phosphatidylinositol-4,5-bisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 4' and 5' positions." [GOC:bf, GOC:jl]


id: GO:0005547
name: phosphatidylinositol-3,4,5-trisphosphate binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with phosphatidylinositol-3,4,5-trisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 3', 4' and 5' positions." [GOC:bf, GOC:jl]


id: GO:0005548
name: phospholipid transporter activity
namespace: molecular_function
def:
  "Enables the directed movement of phospholipids into, out of or within a cell, or between cells. Phospholipids are a class of lipids containing phosphoric acid as a mono- or diester." [GOC:ai, ISBN:0198506732]


id: GO:0005549
name: odorant binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544]


id: GO:0005550
name: pheromone binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with a pheromone, a substance, or characteristic mixture of substances, that is secreted and released by an organism and detected by a second organism of the same or a closely related species, in which it causes a specific reaction, such as a definite behavioral reaction or a developmental process." [GOC:ai]


id: GO:0005553
name: obsolete ubiquitin-ribosomal protein fusion protein
namespace: molecular_function
def:
  "OBSOLETE. A protein encoded by some ubiquitin genes which consists of a single copy of ubiquitin fused to a ribosomal protein." [ISBN:0198506732]


id: GO:0005575
name: cellular_component
namespace: cellular_component
def:
  "The part of a cell or its extracellular environment in which a gene product is located. A gene product may be located in one or more parts of a cell and its location may be as specific as a particular macromolecular complex, that is, a stable, persistent association of macromolecules that function together." [GOC:go_curators, NIF_Subcellular:sao-1337158144]


id: GO:0005576
name: extracellular region
namespace: cellular_component
def:
  "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators]


id: GO:0005577
name: fibrinogen complex
namespace: cellular_component
def:
  "A highly soluble, elongated protein complex found in blood plasma and involved in clot formation. It is converted into fibrin monomer by the action of thrombin. In the mouse, fibrinogen is a hexamer, 46 nm long and 9 nm maximal diameter, containing two sets of nonidentical chains (alpha, beta, and gamma) linked together by disulfide bonds." [ISBN:0198547684]


id: GO:0005578
name: proteinaceous extracellular matrix
namespace: cellular_component
def:
  "A layer consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that forms a sheet underlying or overlying cells such as endothelial and epithelial cells. The proteins are secreted by cells in the vicinity. An example of this component is found in Mus musculus." [GOC:mtg_sensu, ISBN:0198547684]


id: GO:0005579
name: membrane attack complex
namespace: cellular_component
def:
  "A protein complex produced by sequentially activated components of the complement cascade inserted into a target cell membrane and forming a pore leading to cell lysis via ion and water flow." [GOC:add, ISBN:0198547684, ISBN:068340007X, ISBN:0781735149]


id: GO:0005581
name: collagen trimer
namespace: cellular_component
def:
  "A protein complex consisting of three collagen chains assembled into a left-handed triple helix. These trimers typically assemble into higher order structures." [GOC:dos, GOC:mah, ISBN:0721639976, PMID:19693541, PMID:21421911]


id: GO:0005582
name: collagen type XV trimer
namespace: cellular_component
def:
  "A collagen homotrimer of alpha1(XV) chains; a chondroitin sulfate proteoglycan often found in specialized basement membranes where it bridges between fibrils." [PMID:11158616, PMID:11937714, PMID:21421911]


id: GO:0005584
name: collagen type I trimer
namespace: cellular_component
def:
  "A collagen trimer containing alpha(I) chains. The most common form of type I collagen is a heterotrimer containing two alpha1(I) chains and one alpha2(I) chain; homotrimers containing three alpha1(I) chains are also found. Type I collagen triple helices associate to form banded fibrils." [GOC:mah, GOC:sl, ISBN:0721639976]


id: GO:0005585
name: collagen type II trimer
namespace: cellular_component
def:
  "A collagen homotrimer of alpha1(II) chains; type II collagen triple helices associate to form fibrils." [ISBN:0721639976]


id: GO:0005586
name: collagen type III trimer
namespace: cellular_component
def:
  "A collagen homotrimer of alpha1(III) chains; type III collagen triple helices associate to form fibrils." [ISBN:0721639976]


id: GO:0005587
name: collagen type IV trimer
namespace: cellular_component
def:
  "A collagen heterotrimer containing type IV alpha chains; [alpha1(IV)]2alpha2(IV) trimers are commonly observed, although more type IV alpha chains exist and may be present in type IV trimers; type IV collagen triple helices associate to form 3 dimensional nets within basement membranes." [ISBN:0721639976, PMID:19693541, PMID:21421911]


id: GO:0005588
name: collagen type V trimer
namespace: cellular_component
def:
  "A collagen heterotrimer containing type V alpha chains; [alpha1(V)]2alpha2(V) and alpha1(V)alpha2(V)alpha3(V) trimers have been observed; type V collagen triple helices associate to form fibrils." [ISBN:0721639976]


id: GO:0005589
name: collagen type VI trimer
namespace: cellular_component
def:
  "A collagen heterotrimer containing type VI alpha chains in alpha1(VI)alpha2(VI)alpha3(VI) trimers; type VI collagen triple helices associate to form beaded fibrils." [ISBN:0721639976, PMID:19693541, PMID:21421911]


id: GO:0005590
name: collagen type VII trimer
namespace: cellular_component
def:
  "A collagen homotrimer of alpha1(VII) chains; type VII collagen triple helices form antiparallel dimer, which in turn associate laterally to form anchoring fibrils that connect type IV collagen in the basal lamina to plaques in the underlying connective tissue. It binds laminin." [ISBN:0721639976] {comment="PMID:19693541"}


id: GO:0005591
name: collagen type VIII trimer
namespace: cellular_component
def:
  "A collagen heterotrimer containing type VIII alpha chains; [alpha1(VIII)2]alpha2(VIII) and alpha1(VIII)[alpha2(VIII)]2 trimers have been observed; type VIII collagen triple helices associate to form regular hexagonal nets." [ISBN:0721639976, PMID:21421911]


id: GO:0005592
name: collagen type XI trimer
namespace: cellular_component
def:
  "A collagen heterotrimer containing type XI alpha chains in alpha1(XI)alpha2(XI)alpha3(XI) trimers; type XI collagen triple helices associate to form fibrils." [ISBN:0721639976]


id: GO:0005593
name: FACIT collagen trimer
namespace: cellular_component
def:
  "A collagen trimer that associates with collagen fibrils and consists of collagen monomers that contain two or more relatively short triple-helical domains connected by non-triple-helical sequences." [ISBN:0198599587, PMID:21421911]


id: GO:0005594
name: collagen type IX trimer
namespace: cellular_component
def:
  "A collagen heterotrimer containing type IX alpha chains in alpha1(IX)alpha2(IX)alpha3(IX) trimers; type IX collagen triple helices associate to form a structure that links glycosaminoglycans to type II collagen fibrils." [ISBN:0721639976]


id: GO:0005595
name: collagen type XII trimer
namespace: cellular_component
def:
  "A collagen homotrimer of alpha1(XII) chains; type XII collagen triple helices may link sheet-forming or fibrillar collagens to other structures." [ISBN:0721639976]


id: GO:0005596
name: collagen type XIV trimer
namespace: cellular_component
def:
  "A collagen homotrimer of alpha1(XIV) chains; type XIV collagen triple helices may link sheet-forming or fibrillar collagens to other structures." [ISBN:0721639976]


id: GO:0005597
name: collagen type XVI trimer
namespace: cellular_component
def:
  "A collagen trimer containing alpha(XVI) chains; type XVI trimers can associate with microfibrils." [GOC:mah, PMID:12782140]


id: GO:0005598
name: short-chain collagen trimer
namespace: cellular_component
def:
  "Any collagen trimer that does not form fibrils and that is relatively short compared to the collagen trimers that do form fibrils." [ISBN:0198599587]


id: GO:0005599
name: collagen type X trimer
namespace: cellular_component
def:
  "A collagen homotrimer of alpha1(X) chains; type X collagen triple helices form hexagonal networks (sheets)." [ISBN:0721639976, PMID:21421911]


id: GO:0005600
name: collagen type XIII trimer
namespace: cellular_component
def:
  "A collagen homotrimer of alpha1(XIII) chains; type XIII collagen triple helices span the plasma membrane." [GOC:bm, GOC:dos, ISBN:0721639976]


id: GO:0005601
name: classical-complement-pathway C3/C5 convertase complex
namespace: cellular_component
def:
  "A heterodimeric protein complex that catalyzes the cleavage of complement components C3 and C5, and acts in the classical pathway of complement activation; consists of one monomer of C2a and one monomer of C4b; C2a is the catalytic subunit, but cannot catalyze cleavage alone." [BRENDA:3.4.21.43, GOC:mah, http://users.rcn.com/jkimball.ma.ultranet/BiologyPages/C/Complement.html]


id: GO:0005602
name: complement component C1 complex
namespace: cellular_component
def:
  "A protein complex composed of six subunits of C1q, each formed of the three homologous polypeptide chains C1QA, C1QB, and C1QB, and tetramer of two C1QR and two C1QS polypeptide chains." [GOC:add, ISBN:0781735149]


id: GO:0005604
name: basement membrane
namespace: cellular_component
def:
  "A thin layer of dense material found in various animal tissues interposed between the cells and the adjacent connective tissue. It consists of the basal lamina plus an associated layer of reticulin fibers." [ISBN:0198547684]


id: GO:0005605
name: basal lamina
namespace: cellular_component
def:
  "A thin sheet of proteoglycans and glycoproteins, especially laminin, secreted by cells as an extracellular matrix." [ISBN:0198547684]


id: GO:0005606
name: laminin-1 complex
namespace: cellular_component
def:
  "A laminin complex composed of alpha1, beta1 and gamma1 polypeptide chains." [GOC:jl, PMID:10842354]


id: GO:0005607
name: laminin-2 complex
namespace: cellular_component
def:
  "A laminin complex composed of alpha2, beta1 and gamma1 polypeptide chains." [GOC:jl, PMID:10842354]


id: GO:0005609
name: laminin-4 complex
namespace: cellular_component
def:
  "A laminin complex composed of alpha2, beta2 and gamma1 polypeptide chains." [GOC:jl, PMID:10842354]


id: GO:0005610
name: laminin-5 complex
namespace: cellular_component
def:
  "A laminin complex composed of alpha3, beta3 and gamma2 polypeptide chains." [GOC:jl, PMID:10842354]


id: GO:0005611
name: laminin-6 complex
namespace: cellular_component
def:
  "A laminin complex composed of alpha3, beta1 and gamma1 polypeptide chains." [GOC:jl, PMID:10842354]


id: GO:0005612
name: laminin-7 complex
namespace: cellular_component
def:
  "A laminin complex composed of alpha3, beta2 and gamma1 polypeptide chains." [GOC:jl, PMID:10842354]


id: GO:0005614
name: interstitial matrix
namespace: cellular_component
def:
  "A type of extracellular matrix found in interstitial connective tissue, characterized by the presence of fibronectins, proteoglycans, and types I, III, V, VI, VII and XII collagens." [PMID:8450001]


id: GO:0005615
name: extracellular space
namespace: cellular_component
def:
  "That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684]


id: GO:0005616
name: larval serum protein complex
namespace: cellular_component
def:
  "A multisubunit protein complex which, in Drosophila, is a heterohexamer of three subunits, alpha, beta and gamma. The complex is thought to store amino acids for synthesis of adult proteins." [GOC:jl, PMID:6781759]


id: GO:0005618
name: cell wall
namespace: cellular_component
def:
  "The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, most prokaryotic cells and some protozoan parasites, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan; in protozoan parasites such as Giardia species, it's made of carbohydrates and proteins." [GOC:giardia, http://en.wikipedia.org/wiki/Microbial_cyst, ISBN:0198547684, PMID:15134259]


id: GO:0005619
name: ascospore wall
namespace: cellular_component
def:
  "The specialized cell wall of the ascospore (spore), which is the product of meiotic division. Examples of this component are found in Fungi." [GOC:vw, ISBN:0879693568]


id: GO:0005621
name: cellular bud scar
namespace: cellular_component
def:
  "Crater-like ring of chitinous scar tissue located on the surface of the mother cell. It is formed after the newly emerged daughter cell separates thereby marking the site of cytokinesis and septation. The number of bud scars that accumulate on the surface of a cell is a useful determinant of replicative age." [GOC:rn, PMID:14600225, PMID:2005820]


id: GO:0005622
name: intracellular
namespace: cellular_component
def:
  "The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732]


id: GO:0005623
name: cell
namespace: cellular_component
def:
  "The basic structural and functional unit of all organisms. Includes the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope." [GOC:go_curators]


id: GO:0005624
name: obsolete membrane fraction
namespace: cellular_component
def:
  "OBSOLETE: That fraction of cells, prepared by disruptive biochemical methods, that includes the plasma and other membranes." [GOC:ma]


id: GO:0005625
name: obsolete soluble fraction
namespace: cellular_component
def:
  "OBSOLETE: That fraction of cells, prepared by disruptive biochemical methods, that is soluble in water." [GOC:ma]


id: GO:0005626
name: obsolete insoluble fraction
namespace: cellular_component
def:
  "OBSOLETE: That fraction of cells, prepared by disruptive biochemical methods, that is not soluble in water." [GOC:ma]


id: GO:0005627
name: obsolete ascus
namespace: cellular_component
def:
  "OBSOLETE. A sac-like fruiting body (ascomycete Fungi); contains ascospores (typically eight in number)." [ISBN:0198547684]


id: GO:0005628
name: prospore membrane
namespace: cellular_component
def:
  "The prospore membrane is a double-membraned structure that extends from the cytoplasmic face of the spindle pole bodies to encompass the spindle pole bodies and the four nuclear lobes that are formed during meiosis. It helps isolate the meiotic nuclei from the cytoplasm during spore formation and serves as a foundation for the formation of the spore walls. An example of this component is found in Schizosaccharomyces pombe." [ISBN:0879693649]


id: GO:0005632
name: inner layer of spore wall
namespace: cellular_component
def:
  "Either of the two innermost layers of the spore wall, as described in Saccharomyces." [ISBN:0879693568]


id: GO:0005633
name: ascus lipid particle
namespace: cellular_component
def:
  "Any particle of coalesced lipids in an ascus or ascospore. May include associated proteins." [GOC:mah, PMID:12702293]


id: GO:0005634
name: nucleus
namespace: cellular_component
def:
  "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators]


id: GO:0005635
name: nuclear envelope
namespace: cellular_component
def:
  "The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space)." [ISBN:0198547684]


id: GO:0005638
name: lamin filament
namespace: cellular_component
def:
  "Any of a group of intermediate-filament proteins that form the fibrous matrix on the inner surface of the nuclear envelope. They are classified as lamins A, B and C." [ISBN:0198547684]


id: GO:0005639
name: integral component of nuclear inner membrane
namespace: cellular_component
def:
  "The component of the nuclear inner membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:go_curators]


id: GO:0005640
name: nuclear outer membrane
namespace: cellular_component
def:
  "The outer, i.e. cytoplasm-facing, lipid bilayer of the nuclear envelope; continuous with the endoplasmic reticulum of the cell and sometimes studded with ribosomes." [ISBN:0198547684]


id: GO:0005642
name: annulate lamellae
namespace: cellular_component
def:
  "Stacks of endoplasmic reticulum (ER) membranes containing a high density of nuclear pores, thought to form from excess nuclear membrane components, that have been described in a number of different cells. Annulate lamellar membranes are continuous with and embedded within the ER." [PMID:12631728]


id: GO:0005643
name: nuclear pore
namespace: cellular_component
def:
  "Any of the numerous similar discrete openings in the nuclear envelope of a eukaryotic cell, where the inner and outer nuclear membranes are joined." [ISBN:0198547684]


id: GO:0005652
name: nuclear lamina
namespace: cellular_component
def:
  "The fibrous, electron-dense layer lying on the nucleoplasmic side of the inner membrane of a cell nucleus, composed of lamin filaments. The polypeptides of the lamina are thought to be concerned in the dissolution of the nuclear envelope and its re-formation during mitosis. The lamina is composed of lamin A and lamin C filaments cross-linked into an orthogonal lattice, which is attached via lamin B to the inner nuclear membrane through interactions with a lamin B receptor, an IFAP, in the membrane." [ISBN:0198506732, ISBN:0716731363]


id: GO:0005654
name: nucleoplasm
namespace: cellular_component
def:
  "That part of the nuclear content other than the chromosomes or the nucleolus." [GOC:ma, ISBN:0124325653]


id: GO:0005655
name: nucleolar ribonuclease P complex
namespace: cellular_component
def:
  "A ribonuclease P complex located in the nucleolus of a eukaryotic cell, where it catalyzes the 5' endonucleolytic cleavage of precursor tRNAs to yield mature tRNAs. Eukaryotic nucleolar ribonuclease P complexes generally contain a single RNA molecule that is necessary but not sufficient for catalysis, and several protein molecules." [GOC:mah, PMID:12045094]


id: GO:0005656
name: nuclear pre-replicative complex
namespace: cellular_component
def:
  "A protein-DNA complex assembled at eukaryotic DNA replication origins during late mitosis and G1, allowing the origin to become competent, or 'licensed', for replication. The complex normally includes the origin recognition complex (ORC), Cdc6, Cdt1 and the MiniChromosome Maintenance (Mcm2-7) proteins." [PMID:15222894]


id: GO:0005657
name: replication fork
namespace: cellular_component
def:
  "The Y-shaped region of a replicating DNA molecule, resulting from the separation of the DNA strands and in which the synthesis of new strands takes place. Also includes associated protein complexes." [GOC:mah, ISBN:0198547684]


id: GO:0005658
name: alpha DNA polymerase:primase complex
namespace: cellular_component
def:
  "A complex of four polypeptides, comprising large and small DNA polymerase alpha subunits and two primase subunits, which catalyzes the synthesis of an RNA primer on the lagging strand of replicating DNA; the smaller of the two primase subunits alone can catalyze oligoribonucleotide synthesis." [GOC:mah, PMID:11395402]


id: GO:0005660
name: obsolete delta-DNA polymerase cofactor complex
namespace: cellular_component
def:
  "OBSOLETE. A complex of proteins that interacts with delta-DNA polymerase, promoting elongation. In humans it is a heteropentamer of subunits of 140/145, 40, 38, 37 and 36.5 kDa, which form a complex with the proliferating cell nuclear antigen (PCNA) in the presence of ATP." [GOC:jl]


id: GO:0005662
name: DNA replication factor A complex
namespace: cellular_component
def:
  "A conserved heterotrimeric complex that binds nonspecifically to single-stranded DNA and is required for multiple processes in eukaryotic DNA metabolism, including DNA replication, DNA repair, and recombination. In all eukaryotic organisms examined the complex is composed of subunits of approximately 70, 30, and 14 kDa." [PMID:9242902]


id: GO:0005663
name: DNA replication factor C complex
namespace: cellular_component
def:
  "A complex that loads the DNA polymerase processivity factor proliferating cell nuclear antigen (PCNA) onto DNA, thereby permitting processive DNA synthesis catalyzed by DNA polymerase. In eukaryotes the complex consists of five polypeptides." [PMID:14614842, PMID:14646196, PMID:16172520]


id: GO:0005664
name: nuclear origin of replication recognition complex
namespace: cellular_component
def:
  "A multisubunit complex that is located at the replication origins of a chromosome in the nucleus." [GOC:elh]


id: GO:0005665
name: DNA-directed RNA polymerase II, core complex
namespace: cellular_component
def:
  "RNA polymerase II, one of three nuclear DNA-directed RNA polymerases found in all eukaryotes, is a multisubunit complex; typically it produces mRNAs, snoRNAs, and some of the snRNAs. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The largest subunit of RNA polymerase II contains an essential carboxyl-terminal domain (CTD) composed of a variable number of heptapeptide repeats (YSPTSPS). The remainder of the complex is composed of smaller subunits (generally ten or more), some of which are also found in RNA polymerases I and III. Although the core is competent to mediate ribonucleic acid synthesis, it requires additional factors to select the appropriate template." [GOC:krc, GOC:mtg_sensu]


id: GO:0005666
name: DNA-directed RNA polymerase III complex
namespace: cellular_component
def:
  "RNA polymerase III, one of three nuclear DNA-directed RNA polymerases found in all eukaryotes, is a multisubunit complex; typically it produces 5S rRNA, tRNAs and some of the small nuclear RNAs. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The remainder of the complex is composed of smaller subunits (generally ten or more), some of which are also found in RNA polymerase I and others of which are also found in RNA polymerases I and II. Although the core is competent to mediate ribonucleic acid synthesis, it requires additional factors to select the appropriate template." [GOC:krc, GOC:mtg_sensu]


id: GO:0005667
name: transcription factor complex
namespace: cellular_component
def:
  "A protein complex that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription." [GOC:jl]


id: GO:0005668
name: RNA polymerase transcription factor SL1 complex
namespace: cellular_component
def:
  "A RNA polymerase I-specific transcription factor complex that contains the TATA-box-binding protein (TBP) and at least three TBP-associated factors including proteins known in mammals as TAFI110, TAFI63 and TAFI48." [PMID:15691654]


id: GO:0005669
name: transcription factor TFIID complex
namespace: cellular_component
def:
  "A complex composed of TATA binding protein (TBP) and TBP associated factors (TAFs); the total mass is typically about 800 kDa. Most of the TAFs are conserved across species. In TATA-containing promoters for RNA polymerase II (Pol II), TFIID is believed to recognize at least two distinct elements, the TATA element and a downstream promoter element. TFIID is also involved in recognition of TATA-less Pol II promoters. Binding of TFIID to DNA is necessary but not sufficient for transcription initiation from most RNA polymerase II promoters." [GOC:krc, GOC:mah, ISBN:0471953393, ISBN:0879695501]


id: GO:0005671
name: Ada2/Gcn5/Ada3 transcription activator complex
namespace: cellular_component
def:
  "A multiprotein complex that possesses histone acetyltransferase and is involved in regulation of transcription. Contains either GCN5 or PCAF in a mutually exclusive manner. The budding yeast complex includes Gcn5p, two proteins of the Ada family, and two TBP-associate proteins (TAFs); analogous complexes in other species have analogous compositions, and usually contain homologs of the yeast proteins. Both ATAC- or SAGA (see GO:0000124, SAGA complex) are involved in the acetylation of histone H3K9 and K14 residues." [PMID:10637607]


id: GO:0005672
name: transcription factor TFIIA complex
namespace: cellular_component
def:
  "A component of the transcription machinery of RNA Polymerase II. In humans, TFIIA is a heterotrimer composed of an alpha (P35), beta (P19) and gamma subunits (P12)." [GOC:jl, PMID:17560669]


id: GO:0005673
name: transcription factor TFIIE complex
namespace: cellular_component
def:
  "A transcription factor which in humans consists of a complex of two alpha and two beta chains. Recruits TFIIH to the initiation complex and helps activate both RNA polymerase II and TFIIH." [GOC:jl, PMID:16547462]


id: GO:0005674
name: transcription factor TFIIF complex
namespace: cellular_component
def:
  "A general transcription initiation factor which in humans consists of a heterodimer of an alpha and a beta subunit. Helps recruit RNA polymerase II to the initiation complex and promotes translation elongation." [GOC:jl, PMID:7597077]


id: GO:0005675
name: holo TFIIH complex
namespace: cellular_component
def:
  "A complex that is capable of kinase activity directed towards the C-terminal Domain (CTD) of the largest subunit of RNA polymerase II and is essential for initiation at RNA polymerase II promoters in vitro. It is composed of  the core TFIIH complex and the TFIIK complex." [GOC:ew, GOC:krc, PMID:14500720, PMID:22308316, PMID:22572993, PMID:7813015]


id: GO:0005677
name: chromatin silencing complex
namespace: cellular_component
def:
  "Any protein complex that mediates changes in chromatin structure that result in transcriptional silencing." [GOC:mah]


id: GO:0005678
name: obsolete chromatin assembly complex
namespace: cellular_component
def:
  "OBSOLETE: Any protein complex that acts in the formation of nucleosomes or higher order chromatin structure." [GOC:mah]


id: GO:0005680
name: anaphase-promoting complex
namespace: cellular_component
def:
  "A ubiquitin ligase complex that degrades mitotic cyclins and anaphase inhibitory protein, thereby triggering sister chromatid separation and exit from mitosis. Substrate recognition by APC occurs through degradation signals, the most common of which is termed the Dbox degradation motif, originally discovered in cyclin B." [GOC:jh, GOC:vw, PMID:10465783, PMID:10611969]


id: GO:0005681
name: spliceosomal complex
namespace: cellular_component
def:
  "Any of a series of ribonucleoprotein complexes that contain snRNA(s) and small nuclear ribonucleoproteins (snRNPs), and are formed sequentially during the spliceosomal splicing of one or more substrate RNAs, and which also contain the RNA substrate(s) from the initial target RNAs of splicing, the splicing intermediate RNA(s), to the final RNA products. During cis-splicing, the initial target RNA is a single, contiguous RNA transcript, whether mRNA, snoRNA, etc., and the released products are a spliced RNA and an excised intron, generally as a lariat structure. During trans-splicing, there are two initial substrate RNAs, the spliced leader RNA and a pre-mRNA." [GOC:editors, GOC:mah, ISBN:0198547684, PMID:19239890]


id: GO:0005683
name: U7 snRNP
namespace: cellular_component
def:
  "A ribonucleoprotein complex that contains the U7 snRNA and is required for the 3'-end processing of replication-dependent histone pre-mRNAs." [PMID:12872004]


id: GO:0005684
name: U2-type spliceosomal complex
namespace: cellular_component
def:
  "Any spliceosomal complex that forms during the splicing of a messenger RNA primary transcript to excise an intron that has canonical consensus sequences near the 5' and 3' ends." [GOC:krc, GOC:mah, PMID:11343900]


id: GO:0005689
name: U12-type spliceosomal complex
namespace: cellular_component
def:
  "Any spliceosomal complex that forms during the splicing of a messenger RNA primary transcript to excise an intron; the series of U12-type spliceosomal complexes is involved in the splicing of the majority of introns that contain atypical AT-AC terminal dinucleotides, as well as other non-canonical introns. The entire splice site signal, not just the terminal dinucleotides, is involved in determining which spliceosome utilizes the site." [GOC:krc, GOC:mah, PMID:11574683, PMID:11971955]


id: GO:0005694
name: chromosome
namespace: cellular_component
def:
  "A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information." [ISBN:0198547684]


id: GO:0005695
name: obsolete chromatid
namespace: cellular_component
def:
  "OBSOLETE. One of the two daughter strands of a duplicated chromosome that become apparent between early prophase and metaphase in mitosis and between diplotene and second metaphase in meiosis." [ISBN:0198506732]


id: GO:0005696
name: obsolete telomere
namespace: cellular_component
def:
  "OBSOLETE. A complex of DNA and protein that seals the end of a chromosome. The telomeric DNA consists of simple tandemly repeated sequences specific for each species. Typically one strand is G-rich and the other C-rich. The G-rich strand forms a 3'-terminal overhang, the length of which varies with species. The single strand overhang is bound by a variety of proteins, including telomere capping proteins that bind to the single-stranded DNA." [ISBN:0198506732, PMID:11352055]


id: GO:0005697
name: telomerase holoenzyme complex
namespace: cellular_component
def:
  "Telomerase is a ribonucleoprotein enzyme complex, with a minimal catalytic core composed of a catalytic reverse transcriptase subunit and an RNA subunit that provides the template for telomeric DNA addition. In vivo, the holoenzyme complex often contains additional subunits." [PMID:11884619]


id: GO:0005698
name: obsolete centromere
namespace: cellular_component
def:
  "OBSOLETE. The region of a eukaryotic chromosome that is attached to the spindle during nuclear division. It is defined genetically as the region of the chromosome that always segregates at the first division of meiosis; the region of the chromosome in which no crossing over occurs. At the start of M phase, each chromosome consists of two sister chromatids with a constriction at a point which forms the centromere. During late prophase two kinetochores assemble on each centromere, one kinetochore on each sister chromatid." [ISBN:0198506732]


id: GO:0005700
name: polytene chromosome
namespace: cellular_component
def:
  "A type of chromosome in a polyploid cell, formed when multiple copies of homologous chromosomes are aligned side by side to give a giant chromosome in which distinct chromosome bands are readily visible." [ISBN:0198506732]


id: GO:0005701
name: polytene chromosome chromocenter
namespace: cellular_component
def:
  "A region at which the centric regions of polytene chromosomes are joined together." [GOC:bf, ISBN:0120649012]


id: GO:0005702
name: polytene chromosome weak point
namespace: cellular_component
def:
  "A region of the polytene chromosome where the diameter is considerably decreased, probably resulting from local differences in chromosome organization." [GOC:bf, ISBN:0120649012]


id: GO:0005703
name: polytene chromosome puff
namespace: cellular_component
def:
  "A swelling at a site along the length of a polytene chromosome, thought to be the site of active transcription." [GOC:bf, ISBN:0120649012]


id: GO:0005704
name: polytene chromosome band
namespace: cellular_component
def:
  "A stretch of densely packed chromatin along the polytene chromosome, visible as a morphologically distinct band." [GOC:bf, PMID:11361342]


id: GO:0005705
name: polytene chromosome interband
namespace: cellular_component
def:
  "A stretch of less tightly packed chromatin along the polytene chromosome, found between bands." [GOC:bf, PMID:11361342]


id: GO:0005706
name: polytene chromosome ectopic fiber
namespace: cellular_component
def:
  "A thread-like connection joining two regions of ectopically paired polytene chromosomes." [GOC:bf, ISBN:0120649012]


id: GO:0005707
name: obsolete interphase chromosome
namespace: cellular_component
def:
  "OBSOLETE. A chromosome found in the cell during interphase of the cell cycle. Chromosomes are usually decondensed during interphase and each long DNA molecule in a chromosome is divided into a large number of discrete domains that are folded differently." [GOC:ai, ISBN:0815316194]


id: GO:0005710
name: obsolete metaphase chromosome
namespace: cellular_component
def:
  "OBSOLETE. A chromosome found in the cell during metaphase. Typically, sister chromatids are held together at their centromeres and chromosomes are covered with a large number of molecules, including ribonucleoproteins." [GOC:ai]


id: GO:0005712
name: chiasma
namespace: cellular_component
def:
  "A connection formed between chromatids, visible during meiosis, thought to be the point of the interchange involved in crossing-over." [ISBN:0198506732]


id: GO:0005714
name: early recombination nodule
namespace: cellular_component
def:
  "An electron dense structure that is associated with meiotic chromosomes in leptotene or zygotene during meiosis I." [GOC:elh]


id: GO:0005715
name: late recombination nodule
namespace: cellular_component
def:
  "An electron dense structure that is associated with meiotic chromosomes in pachytene during meiosis I." [GOC:elh]


id: GO:0005719
name: nuclear euchromatin
namespace: cellular_component
def:
  "The dispersed less dense form of chromatin in the interphase nucleus. It exists in at least two forms, a some being in the form of transcriptionally active chromatin which is the least condensed, while the rest is inactive euchromatin which is more condensed than active chromatin but less condensed than heterochromatin." [ISBN:0198506732]


id: GO:0005720
name: nuclear heterochromatin
namespace: cellular_component
def:
  "A condensed form of chromatin, occurring in the nucleus during interphase, that stains strongly with basophilic dyes. The DNA of heterochromatin is typically replicated at a later stage in the cell-division cycle than euchromatin." [ISBN:0198506732]


id: GO:0005721
name: pericentric heterochromatin
namespace: cellular_component
def:
  "Heterochromatin that is located adjacent to the CENP-A rich centromere 'central core' and characterized by the modified histone H3K9me3." [PMID:12019236, PMID:20206496, PMID:22729156]


id: GO:0005722
name: beta-heterochromatin
namespace: cellular_component
def:
  "A diffusely banded region of heterochromatin located between euchromatin and alpha-heterochromatin in the polytene chromosome chromocenter; normally replicated during polytenization." [PMID:11404334, PMID:8878678]


id: GO:0005723
name: alpha-heterochromatin
namespace: cellular_component
def:
  "A small, compact region of heterochromatin located in the middle of the polytene chromosome chromocenter, which undergoes little or no replication during polytenization." [PMID:8878678]


id: GO:0005724
name: nuclear telomeric heterochromatin
namespace: cellular_component
def:
  "Heterochromatic regions of the chromosome found at the telomeres of a chromosome in the nucleus." [GOC:ai]


id: GO:0005725
name: intercalary heterochromatin
namespace: cellular_component
def:
  "Any of the regions of heterochromatin that form a reproducible set of dense bands scattered along the euchromatic arms in polytene chromosomes." [PMID:14579245]


id: GO:0005726
name: perichromatin fibrils
namespace: cellular_component
def:
  "Structures of variable diameter visible in the nucleoplasm by electron microscopy, mainly observed near the border of condensed chromatin. The fibrils are enriched in RNA, and are believed to be sites of pre-mRNA splicing and polyadenylylation representing the in situ form of nascent transcripts." [PMID:14731598]


id: GO:0005728
name: extrachromosomal rDNA circle
namespace: cellular_component
def:
  "Circular DNA molecules encoding ribosomal RNA that are replicated independently of chromosomal replication. These molecules originate in the chromosome but are excised and circularized, often by intramolecular homologous recombination between direct tandem repeats." [GOC:mah, PMID:12044934]


id: GO:0005729
name: 2-micrometer circle DNA
namespace: cellular_component
def:
  "A plasmid commonly found in Saccharomyces, inherited in a non-Mendelian manner and often present in 100-400 copies." [PMID:12073320]


id: GO:0005730
name: nucleolus
namespace: cellular_component
def:
  "A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732]


id: GO:0005731
name: nucleolus organizer region
namespace: cellular_component
def:
  "A region of a chromosome where nucleoli form during interphase, and where genes encoding the largest rRNA precursor transcript are tandemly arrayed." [PMID:14504406]


id: GO:0005732
name: small nucleolar ribonucleoprotein complex
namespace: cellular_component
def:
  "A ribonucleoprotein complex that contains an RNA molecule of the small nucleolar RNA (snoRNA) family and associated proteins. Most are involved in a step of processing of rRNA: cleavage, 2'-O-methylation, or pseudouridylation. The majority, though not all, fall into one of two classes, box C/D type or box H/ACA type." [GOC:krc, GOC:mah, ISBN:0879695897]


id: GO:0005736
name: DNA-directed RNA polymerase I complex
namespace: cellular_component
def:
  "RNA polymerase I, one of three nuclear DNA-directed RNA polymerases found in all eukaryotes, is a multisubunit complex; typically it produces rRNAs. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The remainder of the complex is composed of smaller subunits (generally ten or more), some of which are also found in RNA polymerase III and others of which are also found in RNA polymerases II and III. Although the core is competent to mediate ribonucleic acid synthesis, it requires additional factors to select the appropriate template." [GOC:krc, GOC:mtg_sensu]


id: GO:0005737
name: cytoplasm
namespace: cellular_component
def:
  "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684]


id: GO:0005739
name: mitochondrion
namespace: cellular_component
def:
  "A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732]


id: GO:0005740
name: mitochondrial envelope
namespace: cellular_component
def:
  "The double lipid bilayer enclosing the mitochondrion and separating its contents from the cell cytoplasm; includes the intermembrane space." [GOC:ai, GOC:pz]


id: GO:0005742
name: mitochondrial outer membrane translocase complex
namespace: cellular_component
def:
  "A large complex of the mitochondrial outer membrane that mediates transport of proteins into all mitochondrial compartments." [PMID:12581629]


id: GO:0005743
name: mitochondrial inner membrane
namespace: cellular_component
def:
  "The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae." [GOC:ai]


id: GO:0005744
name: mitochondrial inner membrane presequence translocase complex
namespace: cellular_component
def:
  "The protein transport machinery of the mitochondrial inner membrane that contains three essential Tim proteins: Tim17 and Tim23 are thought to build a preprotein translocation channel while Tim44 interacts transiently with the matrix heat-shock protein Hsp70 to form an ATP-driven import motor." [EC:3.6.3.51, PMID:8851659]


id: GO:0005745
name: m-AAA complex
namespace: cellular_component
def:
  "Protease complex of the mitochondrial inner membrane that is involved in mitochondrial protein turnover and in processing of proteins imported into mitochondria." [GOC:mcc, PMID:12417197, PMID:21147776]


id: GO:0005746
name: mitochondrial respiratory chain
namespace: cellular_component
def:
  "The protein complexes that form the mitochondrial electron transport system (the respiratory chain), associated with the inner mitochondrial membrane. The respiratory chain complexes transfer electrons from an electron donor to an electron acceptor and are associated with a proton pump to create a transmembrane electrochemical gradient." [GOC:curators, GOC:ecd, ISBN:0198547684]


id: GO:0005747
name: mitochondrial respiratory chain complex I
namespace: cellular_component
def:
  "A protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial respiratory chain. It contains about 25 different polypeptide subunits, including NADH dehydrogenase (ubiquinone), flavin mononucleotide and several different iron-sulfur clusters containing non-heme iron. The iron undergoes oxidation-reduction between Fe(II) and Fe(III), and catalyzes proton translocation linked to the oxidation of NADH by ubiquinone." [GOC:mtg_sensu, ISBN:0198547684]


id: GO:0005749
name: mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)
namespace: cellular_component
def:
  "A protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial respiratory chain. Contains the four polypeptide subunits of succinate dehydrogenase, flavin-adenine dinucleotide and iron-sulfur. Catalyzes the oxidation of succinate by ubiquinone. Connects the TCA cycle with the respiratory chain." [GOC:mtg_sensu, GOC:vw, ISBN:0198547684]


id: GO:0005750
name: mitochondrial respiratory chain complex III
namespace: cellular_component
def:
  "A protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial respiratory chain. Contains about 10 polypeptide subunits including four redox centers: cytochrome b/b6, cytochrome c1 and an 2Fe-2S cluster. Catalyzes the oxidation of ubiquinol by oxidized cytochrome c1." [GOC:mtg_sensu, ISBN:0198547684]


id: GO:0005751
name: mitochondrial respiratory chain complex IV
namespace: cellular_component
def:
  "A protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial respiratory chain. Contains the 13 polypeptide subunits of cytochrome c oxidase, including cytochrome a and cytochrome a3. Catalyzes the oxidation of reduced cytochrome c by dioxygen (O2)." [GOC:mtg_sensu, ISBN:0198547684]


id: GO:0005753
name: mitochondrial proton-transporting ATP synthase complex
namespace: cellular_component
def:
  "A proton-transporting ATP synthase complex found in the mitochondrial membrane." [GOC:mah, GOC:mtg_sensu]


id: GO:0005754
name: mitochondrial proton-transporting ATP synthase, catalytic core
namespace: cellular_component
def:
  "The hexamer, comprising three alpha and three beta subunits, that possesses the catalytic activity of the mitochondrial hydrogen-transporting ATP synthase." [GOC:mtg_sensu, PMID:10838056]


id: GO:0005756
name: mitochondrial proton-transporting ATP synthase, central stalk
namespace: cellular_component
def:
  "One of two stalks that connect the catalytic core of the hydrogen-transporting ATP synthase to the mitochondrial membrane-associated F0 proteins; rotates within the catalytic core during catalysis." [GOC:mtg_sensu, PMID:10838056]


id: GO:0005757
name: mitochondrial permeability transition pore complex
namespace: cellular_component
def:
  "A protein complex that connects the inner and outer membranes of animal mitochondria and acts as a pore that can open transiently to allow free diffusion of solutes between the mitochondrial matrix and the cytosol. The pore complex is formed of the voltage-dependent anion channel (VDAC), the adenine nucleotide translocase (ANT) and cyclophilin-D (CyP-D)." [PMID:10393078]


id: GO:0005759
name: mitochondrial matrix
namespace: cellular_component
def:
  "The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation." [GOC:as, ISBN:0198506732]


id: GO:0005760
name: gamma DNA polymerase complex
namespace: cellular_component
def:
  "A DNA polymerase complex consisting of a large subunit, responsible for the catalytic activities, and a small accessory subunit. Functions in the replication and repair of mitochondrial DNA." [GOC:jl, PMID:12045093]


id: GO:0005761
name: mitochondrial ribosome
namespace: cellular_component
def:
  "A ribosome found in the mitochondrion of a eukaryotic cell; contains a characteristic set of proteins distinct from those of cytosolic ribosomes." [GOC:mah, ISBN:0198506732]


id: GO:0005762
name: mitochondrial large ribosomal subunit
namespace: cellular_component
def:
  "The larger of the two subunits of a mitochondrial ribosome. Two sites on the ribosomal large subunit are involved in translation: the aminoacyl site (A site) and peptidyl site (P site)." [GOC:mcc]


id: GO:0005764
name: lysosome
namespace: cellular_component
def:
  "A small lytic vacuole that has cell cycle-independent morphology and is found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions." [GOC:mah, ISBN:0198506732]


id: GO:0005765
name: lysosomal membrane
namespace: cellular_component
def:
  "The lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm." [GOC:ai]


id: GO:0005767
name: secondary lysosome
namespace: cellular_component
def:
  "Vacuole formed by the fusion of a lysosome with an organelle (autosome) or with a primary phagosome." [GOC:jl, ISBN:0815316194]


id: GO:0005768
name: endosome
namespace: cellular_component
def:
  "A membrane-bounded organelle to which materials ingested by endocytosis are delivered." [ISBN:0198506732, PMID:19696797]


id: GO:0005769
name: early endosome
namespace: cellular_component
def:
  "A membrane-bounded organelle that receives incoming material from primary endocytic vesicles that have been generated by clathrin-dependent and clathrin-independent endocytosis; vesicles fuse with the early endosome to deliver cargo for sorting into recycling or degradation pathways." [GOC:mah, NIF_Subcellular:nlx_subcell_20090701, PMID:19696797]


id: GO:0005770
name: late endosome
namespace: cellular_component
def:
  "A prelysosomal endocytic organelle differentiated from early endosomes by lower lumenal pH and different protein composition. Late endosomes are more spherical than early endosomes and are mostly juxtanuclear, being concentrated near the microtubule organizing center." [NIF_Subcellular:nlx_subcell_20090702, PMID:11964142, PMID:2557062]


id: GO:0005771
name: multivesicular body
namespace: cellular_component
def:
  "A type of endosome in which regions of the limiting endosomal membrane invaginate to form internal vesicles; membrane proteins that enter the internal vesicles are sequestered from the cytoplasm." [PMID:11566881, PMID:16533950]


id: GO:0005773
name: vacuole
namespace: cellular_component
def:
  "A closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material. Cells contain one or several vacuoles, that may have different functions from each other. Vacuoles have a diverse array of functions. They can act as a storage organelle for nutrients or waste products, as a degradative compartment, as a cost-effective way of increasing cell size, and as a homeostatic regulator controlling both turgor pressure and pH of the cytosol." [GOC:mtg_sensu, ISBN:0198506732]


id: GO:0005774
name: vacuolar membrane
namespace: cellular_component
def:
  "The lipid bilayer surrounding the vacuole and separating its contents from the cytoplasm of the cell." [GOC:ai]


id: GO:0005776
name: autophagosome
namespace: cellular_component
def:
  "A double-membrane-bounded compartment that engulfs endogenous cellular material as well as invading microorganisms to target them to the vacuole/lysosome for degradation as part of macroautophagy." [GOC:autophagy, ISBN:0198547684, PMID:11099404]


id: GO:0005777
name: peroxisome
namespace: cellular_component
def:
  "A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism." [GOC:pm, PMID:9302272, UniProtKB-KW:KW-0576]


id: GO:0005779
name: integral component of peroxisomal membrane
namespace: cellular_component
def:
  "The component of the peroxisomal membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:mah]


id: GO:0005780
name: extrinsic component of intraperoxisomal membrane
namespace: cellular_component
def:
  "The component of the intraperoxisomal membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:dos, GOC:jl, GOC:mah]


id: GO:0005782
name: peroxisomal matrix
namespace: cellular_component
def:
  "The volume contained within the membranes of a peroxisome; in many cells the matrix contains a crystalloid core largely composed of urate oxidase." [GOC:curators, ISBN:0815316194]


id: GO:0005783
name: endoplasmic reticulum
namespace: cellular_component
def:
  "The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732]


id: GO:0005784
name: Sec61 translocon complex
namespace: cellular_component
def:
  "A translocon complex that contains a core heterotrimer of conserved alpha, beta and gamma subunits, and may contain additional proteins (translocon-associated proteins or TRAPs); in budding yeast the core proteins are Sec61p, Sbh1p, and Sss1p. The Sec61 translocon complex functions in cotranslational and posttranslational translocation events." [GOC:mah, PMID:18166647]


id: GO:0005785
name: signal recognition particle receptor complex
namespace: cellular_component
def:
  "A transmembrane heterodimeric protein located in the membrane of the rough endoplasmic reticulum. Both subunits contain GTPase domains with which signal recognition particle interacts. In the presence of GTP and SRP receptor, SRP is released from the ribosome-nascent chain complex." [ISBN:0198506732]


