# go

id: GO:0042299
name: lupeol synthase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: (S)-2,3-epoxysqualene = lupeol. This reaction is the cyclization of (S)-2,3-epoxysqualene (2,3-oxidosqualene) to lupeol." [MetaCyc:RXN-111, PMID:9883589]


id: GO:0042300
name: beta-amyrin synthase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: (S)-2,3-epoxysqualene = beta-amyrin. This reaction is the cyclization and rearrangement of (S)-2,3-epoxysqualene (2,3-oxidosqualene) into beta-amyrin." [PMID:9746369]


id: GO:0042303
name: molting cycle
namespace: biological_process
def:
  "The periodic casting off and regeneration of an outer covering of cuticle, feathers, hair, horns, skin, etc." [GOC:jl, ISBN:0198506732]


id: GO:0042304
name: regulation of fatty acid biosynthetic process
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of fatty acids, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils." [GOC:go_curators, GOC:jl]


id: GO:0042305
name: specification of segmental identity, mandibular segment
namespace: biological_process
def:
  "The specification of the characteristic structures of the mandibular segment following establishment of segment boundaries. Identity is considered to be the aggregate of characteristics by which a structure is recognized." [ISBN:0878932437]


id: GO:0042306
name: regulation of protein import into nucleus
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of movement of proteins from the cytoplasm to the nucleus." [GOC:jl]


id: GO:0042307
name: positive regulation of protein import into nucleus
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of movement of proteins from the cytoplasm into the nucleus." [GOC:jl]


id: GO:0042308
name: negative regulation of protein import into nucleus
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of the movement of proteins from the cytoplasm into the nucleus." [GOC:jl]


id: GO:0042309
name: homoiothermy
namespace: biological_process
def:
  "Any homoeostatic process in which an organism maintains its internal body temperature at a relatively constant value. This is achieved by using metabolic processes to counteract fluctuations in the temperature of the environment." [ISBN:0192801023]


id: GO:0042310
name: vasoconstriction
namespace: biological_process
def:
  "A decrease in the diameter of blood vessels, especially arteries, usually causing an increase in blood pressure." [ISBN:0192800752]


id: GO:0042311
name: vasodilation
namespace: biological_process
def:
  "An increase in the internal diameter of blood vessels, especially arterioles or capillaries, usually resulting in a decrease in blood pressure." [ISBN:0192800981]


id: GO:0042312
name: regulation of vasodilation
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of increases in the diameter of blood vessels." [GOC:jl]


id: GO:0042313
name: protein kinase C deactivation
namespace: biological_process
def:
  "Any process resulting in the inhibition or termination of the activity of protein kinase C." [GOC:bf]


id: GO:0042314
name: bacteriochlorophyll binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with bacteriochlorophyll, a form of chlorophyll found in photosynthetic bacteria, such as the purple and green bacteria. There are several types, designated a to g. Bacteriochlorophyll a and bacteriochlorophyll b are structurally similar to the chlorophyll a and chlorophyll b found in plants." [ISBN:0192800981]


id: GO:0042315
name: obsolete cytosol nonspecific dipeptidase activity
namespace: molecular_function
def:
  "OBSOLETE. Catalysis of the hydrolysis of dipeptides, preferentially hydrophobic dipeptides including prolyl amino acids." [EC:3.4.13.18]


id: GO:0042316
name: penicillin metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving any antibiotic that contains the condensed beta-lactamthiazolidine ring system. Penicillins are produced naturally during the growth of various microfungi of the genera Penicillium and Aspergillus." [GOC:jl, ISBN:0198506732]


id: GO:0042317
name: penicillin catabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the breakdown of any antibiotic that contains the condensed beta-lactamthiazolidine ring system." [GOC:jl, ISBN:0198506732]


id: GO:0042318
name: penicillin biosynthetic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of any antibiotic that contains the condensed beta-lactamthiazolidine ring system." [GOC:jl, ISBN:0198506732]


id: GO:0042320
name: regulation of circadian sleep/wake cycle, REM sleep
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of rapid eye movement (REM) sleep." [GOC:jl, PMID:11506998]


id: GO:0042321
name: negative regulation of circadian sleep/wake cycle, sleep
namespace: biological_process
def:
  "Any process that stops, prevents or reduces the duration or quality of sleep, a readily reversible state of reduced awareness and metabolic activity that occurs periodically in many animals." [GOC:go_curators, GOC:jl, ISBN:0192800981]


id: GO:0042322
name: negative regulation of circadian sleep/wake cycle, REM sleep
namespace: biological_process
def:
  "Any process that stops, prevents or reduces the duration or quality of rapid eye movement (REM) sleep." [GOC:go_curators, GOC:jl]


id: GO:0042323
name: negative regulation of circadian sleep/wake cycle, non-REM sleep
namespace: biological_process
def:
  "Any process that stops, prevents or reduces the duration or quality of non-rapid eye movement (NREM) sleep." [GOC:jl]


id: GO:0042325
name: regulation of phosphorylation
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of addition of phosphate groups into a molecule." [GOC:jl]


id: GO:0042326
name: negative regulation of phosphorylation
namespace: biological_process
def:
  "Any process that stops, prevents or decreases the rate of addition of phosphate groups to a molecule." [GOC:jl]


id: GO:0042327
name: positive regulation of phosphorylation
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to a molecule." [GOC:jl]


id: GO:0042328
name: heparan sulfate N-acetylglucosaminyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + heparan sulfate = UDP + (N-acetyl-D-glucosaminyl)-heparan sulfate." [GOC:ma]


id: GO:0042329
name: structural constituent of collagen and cuticulin-based cuticle
namespace: molecular_function
def:
  "The action of a molecule that contributes to the structural integrity of a collagen and cuticulin-based cuticle. An example of this process is found in Caenorhabditis elegans." [GOC:jl, GOC:mtg_sensu]


id: GO:0042330
name: taxis
namespace: biological_process
def:
  "The directed movement of a motile cell or organism in response to an external stimulus." [GOC:jl, ISBN:0192801023]


id: GO:0042331
name: phototaxis
namespace: biological_process
def:
  "The directed movement of a motile cell or organism in response to light." [GOC:jl, ISBN:0192800981]


id: GO:0042333
name: chemotaxis to oxidizable substrate
namespace: biological_process
def:
  "The directed movement of a motile cell or organism in response to the presence of an oxidizable substrate, for example, fructose." [GOC:jl, PMID:11029423]


id: GO:0042334
name: taxis to electron acceptor
namespace: biological_process
def:
  "The directed movement of a motile cell or organism in response to the presence of an alternative electron acceptor, for example, nitrate." [GOC:jl, PMID:11029423]


id: GO:0042335
name: cuticle development
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of a cuticle, the outer layer of some animals and plants, which acts to prevent water loss." [ISBN:0192800825]


id: GO:0042336
name: obsolete cuticle development involved in protein-based cuticle molting cycle
namespace: biological_process
def:
  "OBSOLETE. Synthesis and deposition of a protein-based noncellular, hardened, or membranous secretion from an epithelial sheet, occurring as part of the molting cycle. Examples of this process are found in invertebrate species." [GOC:dph, GOC:mtg_sensu, GOC:tb]


id: GO:0042337
name: cuticle development involved in chitin-based cuticle molting cycle
namespace: biological_process
def:
  "The synthesis and deposition of a chitin-based non-cellular, hardened, or membranous secretion from an epithelial sheet, occurring as part of the molting cycle. An example of this is found in Drosophila melanogaster." [GOC:dph, GOC:jl, GOC:mtg_sensu, GOC:tb]


id: GO:0042338
name: cuticle development involved in collagen and cuticulin-based cuticle molting cycle
namespace: biological_process
def:
  "Synthesis and deposition of a collagen and cuticulin-based noncellular, hardened, or membranous secretion from an epithelial sheet, occurring as part of the molting cycle. An example of this process is found in Caenorhabditis elegans." [GOC:mtg_sensu]


id: GO:0042339
name: keratan sulfate metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving keratan sulfate, a glycosaminoglycan with repeat units consisting of beta-1,4-linked D-galactopyranosyl-beta-(1,4)-N-acetyl-D-glucosamine 6-sulfate and with variable amounts of fucose, sialic acid and mannose units; keratan sulfate chains are covalently linked by a glycosidic attachment through the trisaccharide galactosyl-galactosyl-xylose to peptidyl-threonine or serine residues." [GOC:go_curators]


id: GO:0042340
name: keratan sulfate catabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the breakdown of keratan sulfate, a glycosaminoglycan with repeat units consisting of beta-1,4-linked D-galactopyranosyl-beta-(1,4)-N-acetyl-D-glucosamine 6-sulfate and with variable amounts of fucose, sialic acid and mannose units; keratan sulfate chains are covalently linked by a glycosidic attachment through the trisaccharide galactosyl-galactosyl-xylose to peptidyl-threonine or serine residues." [GOC:go_curators]


id: GO:0042341
name: cyanogenic glycoside metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving cyanogenic glycosides, any glycoside containing a cyano group that is released as hydrocyanic acid on acid hydrolysis; such compounds occur in the kernels of various fruits." [ISBN:0198506732]


id: GO:0042342
name: cyanogenic glycoside catabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the breakdown of cyanogenic glycosides, any glycoside containing a cyano group that is released as hydrocyanic acid on acid hydrolysis; such compounds occur in the kernels of various fruits." [ISBN:0198506732]


id: GO:0042343
name: indole glucosinolate metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of indole glucosinolates. Glucosinolates are sulfur-containing compounds that have a common structure linked to an R group derived from tryptophan; indoles are biologically active substances based on 2,3-benzopyrrole, formed during the catabolism of tryptophan." [http://www.onelook.com/]


id: GO:0042344
name: indole glucosinolate catabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the breakdown of indole glucosinolates, sulfur-containing compounds that have a common structure linked to an R group derived from tryptophan." [http://www.onelook.com]


id: GO:0042345
name: regulation of NF-kappaB import into nucleus
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of the transfer of NF-kappaB, a transcription factor for eukaryotic RNA polymerase II promoters, from the cytoplasm into the nucleus, across the nuclear membrane." [GOC:jl, ISBN:0198506732]


id: GO:0042346
name: positive regulation of NF-kappaB import into nucleus
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of transfer of NF-kappaB, a transcription factor for eukaryotic RNA polymerase II promoters, from the cytoplasm into the nucleus, across the nuclear membrane." [GOC:jl, ISBN:0198506732]


id: GO:0042347
name: negative regulation of NF-kappaB import into nucleus
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of the transfer of NF-kappaB, a transcription factor for eukaryotic RNA polymerase II promoters, from the cytoplasm into the nucleus, across the nuclear membrane." [GOC:jl, ISBN:0198506732]


id: GO:0042348
name: NF-kappaB import into nucleus
namespace: biological_process
def:
  "The directed movement of NF-kappaB, a transcription factor for eukaryotic RNA polymerase II promoters, from the cytoplasm into the nucleus, across the nuclear membrane." [GOC:jl, ISBN:0198506732]


id: GO:0042349
name: guiding stereospecific synthesis activity
namespace: molecular_function
def:
  "The orientation of free radical substrates in such a way that only a particular stereoisomer is synthesized by an enzyme. Best characterized as a function during lignan biosynthesis." [GOC:ma]


id: GO:0042350
name: GDP-L-fucose biosynthetic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of GDP-L-fucose, a substance composed of L-fucose in glycosidic linkage with guanosine diphosphate." [GOC:jl]


id: GO:0042351
name: 'de novo' GDP-L-fucose biosynthetic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of GDP-L-fucose from GDP-D-mannose via GDP-4-dehydro-6-deoxy-D-mannose, requiring the functions of GDP-mannose 4,6-dehydratase (EC:4.2.1.47) and GDP-L-fucose synthase (EC:1.1.1.271)." [EC:1.1.1.271, PMID:11030750]


id: GO:0042352
name: GDP-L-fucose salvage
namespace: biological_process
def:
  "The formation of GDP-L-fucose from L-fucose, without de novo synthesis. L-fucose is phosphorylated by fucokinase and then converted by fucose-1-phosphate guanylyltransferase (EC:2.7.7.30)." [GOC:ma]


id: GO:0042353
name: fucose biosynthetic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of fucose (6-deoxygalactose)." [GOC:jl]


id: GO:0042354
name: L-fucose metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving L-fucose, 6-deoxy-L-galactose, a sugar that occurs in fucans, a class of polysaccharides in seaweeds, especially Fucus species, and in the cell wall matrix of higher plants." [GOC:jl, ISBN:0198506732]


id: GO:0042355
name: L-fucose catabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the breakdown of L-fucose (6-deoxy-Lgalactose)." [GOC:jl]


id: GO:0042356
name: GDP-4-dehydro-D-rhamnose reductase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: GDP-6-deoxy-D-mannose + NAD(P)+ = GDP-4-dehydro-6-deoxy-D-mannose + NAD(P)H + H+. In the reverse reaction, a mixture of GDP-D-rhamnose and its C-4 epimer is formed." [BRENDA:1.1.1.187, EC:1.1.1.187]


id: GO:0042357
name: thiamine diphosphate metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving thiamine diphosphate, a derivative of thiamine (vitamin B1) which acts as a coenzyme in a range of processes including the Krebs cycle." [CHEBI:45931, GOC:jl, ISBN:0198506732]


id: GO:0042358
name: thiamine diphosphate catabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the breakdown of thiamine diphosphate, a derivative of thiamine (vitamin B1) which acts as a coenzyme in a range of processes including the Krebs cycle." [GOC:jl, ISBN:0198506732]


id: GO:0042359
name: vitamin D metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving vitamin D, any of a group of related, fat-soluble compounds that are derived from delta-5,7 steroids and play a central role in calcium metabolism. Specific forms of vitamin D include calciferol (ergocalciferol; vitamin D2) and cholecalciferol (calciol; vitamin D3)." [CHEBI:27300, GOC:mah, ISBN:0471331309]


id: GO:0042360
name: vitamin E metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving vitamin E, tocopherol, which includes a series of eight structurally similar compounds. Alpha-tocopherol is the most active form in humans and is a powerful biological antioxidant." [GOC:jl, ISBN:0198506732]


id: GO:0042361
name: menaquinone catabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the breakdown of menaquinones, any of the quinone-derived compounds synthesized by intestinal bacteria. Structurally, menaquinones consist of a methylated naphthoquinone ring structure and side chains composed of a variable number of unsaturated isoprenoid residues. Menaquinones have vitamin K activity and are known as vitamin K2." [GOC:jl, http://www.dentistry.leeds.ac.uk/biochem/thcme/vitamins.html#k]


id: GO:0042362
name: fat-soluble vitamin biosynthetic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of any of a diverse group of vitamins that are soluble in organic solvents and relatively insoluble in water." [GOC:jl, ISBN:0198506732]


id: GO:0042363
name: fat-soluble vitamin catabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the breakdown of any of a diverse group of vitamins that are soluble in organic solvents and relatively insoluble in water." [GOC:jl, ISBN:0198506732]


id: GO:0042364
name: water-soluble vitamin biosynthetic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of any of a diverse group of vitamins that are soluble in water." [GOC:jl]


id: GO:0042365
name: water-soluble vitamin catabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the breakdown of any of a diverse group of vitamins that are soluble in water." [GOC:jl, http://www.indstate.edu/thcme/mwking/vitamins.html]


id: GO:0042366
name: cobalamin catabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the breakdown of cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom." [GOC:go_curators]


id: GO:0042367
name: biotin catabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the breakdown of biotin, cis-tetrahydro-2-oxothieno(3,4-d)imidazoline-4-valeric acid." [ISBN:0198506732]


id: GO:0042368
name: vitamin D biosynthetic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of vitamin D, any of a group of related, fat-soluble compounds that are derived from delta-5,7 steroids and play a central role in calcium metabolism. Specific forms of vitamin D include calciferol (ergocalciferol; vitamin D2) and cholecalciferol (calciol; vitamin D3)." [CHEBI:27300, GOC:mah, ISBN:0471331309]


id: GO:0042369
name: vitamin D catabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the breakdown of vitamin D, any of a group of related, fat-soluble compounds that are derived from delta-5,7 steroids and play a central role in calcium metabolism. Specific forms of vitamin D include calciferol (ergocalciferol; vitamin D2) and cholecalciferol (calciol; vitamin D3)." [CHEBI:27300, GOC:mah, ISBN:0471331309]


id: GO:0042370
name: thiamine diphosphate dephosphorylation
namespace: biological_process
def:
  "The removal of one or more phosphate groups from thiamine diphosphate, a derivative of thiamine (vitamin B1) which acts as a coenzyme in a range of processes including the Krebs cycle." [GOC:jl, ISBN:0198506732]


id: GO:0042371
name: vitamin K biosynthetic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of any of the forms of vitamin K, quinone-derived vitamins which are involved in the synthesis of blood-clotting factors in mammals." [GOC:jl, http://www.dentistry.leeds.ac.uk/biochem/thcme/vitamins.html#k]


id: GO:0042372
name: phylloquinone biosynthetic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of phylloquinone, vitamin K1, a quinone-derived compound synthesized by green plants." [GOC:jl, http://www.dentistry.leeds.ac.uk/biochem/thcme/vitamins.html#k]


id: GO:0042373
name: vitamin K metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving any of the forms of vitamin K, quinone-derived vitamins which are involved in the synthesis of blood-clotting factors in mammals. Vitamin K substances share a methylated naphthoquinone ring structure and vary in the aliphatic side chains attached to the molecule." [GOC:jl, http://www.dentistry.leeds.ac.uk/biochem/thcme/vitamins.html#k]


id: GO:0042374
name: phylloquinone metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving phylloquinone, a quinone-derived compound synthesized by green plants. Phylloquinone has vitamin K activity and is known as vitamin K1." [GOC:jl, http://www.dentistry.leeds.ac.uk/biochem/thcme/vitamins.html#k]


id: GO:0042376
name: phylloquinone catabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the breakdown of phylloquinone, vitamin K1, a quinone-derived compound synthesized by green plants." [GOC:jl, http://www.dentistry.leeds.ac.uk/biochem/thcme/vitamins.html#k]


id: GO:0042377
name: vitamin K catabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the breakdown of any of the forms of vitamin K, quinone-derived vitamins which are involved in the synthesis of blood-clotting factors in mammals." [GOC:jl, http://www.dentistry.leeds.ac.uk/biochem/thcme/vitamins.html#k]


id: GO:0042380
name: hydroxymethylbutenyl pyrophosphate reductase activity
namespace: molecular_function
def:
  "Catalysis of the formation of both isopentenyl pyrophosphate and dimethylallyl pyrophosphate from (E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate." [GOC:js]


id: GO:0042381
name: hemolymph coagulation
namespace: biological_process
def:
  "Any process in which factors in the hemolymph (the invertebrate equivalent of vertebrate blood and lymph) precipitate into insoluble clots in order to prevent loss of body fluid, and at the same time prevent the movement of microbes. Hemolymph coagulation is also part of the invertebrate humoral immune response." [GOC:jl, ISBN:0198506732, PMID:10561606, PMID:11915949]


id: GO:0042382
name: paraspeckles
namespace: cellular_component
def:
  "Discrete subnuclear bodies in the interchromatin nucleoplasmic space, often located adjacent to nuclear specks. 10-20 paraspeckles are typically found in human cell nuclei." [GOC:jl, PMID:11790299]


id: GO:0042383
name: sarcolemma
namespace: cellular_component
def:
  "The outer membrane of a muscle cell, consisting of the plasma membrane, a covering basement membrane (about 100 nm thick and sometimes common to more than one fiber), and the associated loose network of collagen fibers." [ISBN:0198506732]


id: GO:0042384
name: cilium assembly
namespace: biological_process
def:
  "The assembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:kmv, GOC:pr, GOC:vw, ISBN:0198506732]


id: GO:0042385
name: myosin III complex
namespace: cellular_component
def:
  "A myosin complex containing a class III myosin heavy chain and associated light chains; myosin III is monomeric myosin that serves as a link between the cytoskeleton and the signaling complex involved in phototransduction, and differs from all other myosins in having an N-terminal kinase domain." [GOC:jl, http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html]


id: GO:0042386
name: hemocyte differentiation
namespace: biological_process
def:
  "The process in which a relatively unspecialized cell acquires the characteristics of a mature hemocyte. Hemocytes are blood cells associated with a hemocoel (the cavity containing most of the major organs of the arthropod body) which are involved in defense and clotting of hemolymph, but not involved in transport of oxygen." [CL:0000387, GOC:jl, GOC:mtg_sensu, PMID:9550723]


id: GO:0042387
name: plasmatocyte differentiation
namespace: biological_process
def:
  "The process in which a hemocyte precursor cell acquires the characteristics of the phagocytic blood-cell type, the plasmatocyte. Plasmatocytes are a class of arthropod hemocytes important in the cellular defense response." [PMID:11921077, PMID:8174791]


id: GO:0042388
name: gibberellic acid mediated signaling pathway, G-alpha-dependent
namespace: biological_process
def:
  "A series of molecular signals mediated by the detection of gibberellic acid and dependent on the coupling of the alpha subunit of G proteins to the hormone receptors." [GOC:pj, PMID:11027362]


id: GO:0042389
name: omega-3 fatty acid desaturase activity
namespace: molecular_function
def:
  "Catalysis of the introduction of an omega-3 double bond into the fatty acid hydrocarbon chain." [GOC:jl, PMID:9037020]


id: GO:0042390
name: gibberellic acid mediated signaling pathway, G-alpha-independent
namespace: biological_process
def:
  "A series of molecular signals mediated by the detection of gibberellic acid and not dependent on the coupling of the alpha subunit of G proteins to the hormone receptors." [GOC:pj, PMID:11027362]


id: GO:0042391
name: regulation of membrane potential
namespace: biological_process
def:
  "Any process that modulates the establishment or extent of a membrane potential, the electric potential existing across any membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane." [GOC:jl, GOC:mtg_cardio, GOC:tb, ISBN:0198506732]


id: GO:0042392
name: sphingosine-1-phosphate phosphatase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: sphingosine 1-phosphate + H2O = sphingosine + phosphate." [GOC:jl, PMID:11331102]


id: GO:0042393
name: histone binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with a histone, any of a group of water-soluble proteins found in association with the DNA of plant and animal chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in nonspecific suppression of gene activity." [GOC:jl]


id: GO:0042394
name: obsolete ecdysis, protein-based cuticle
namespace: biological_process
def:
  "OBSOLETE. The shedding of the old protein-based cuticular fragments during the molting cycle. Examples of this process are found in invertebrates." [GOC:jl, GOC:mtg_sensu]


id: GO:0042395
name: ecdysis, collagen and cuticulin-based cuticle
namespace: biological_process
def:
  "The shedding of the old collagen and cuticulin-based cuticle fragments during the molting cycle. Examples of this process are found in invertebrates." [GOC:jl, GOC:mtg_sensu]


id: GO:0042396
name: phosphagen biosynthetic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of phosphagen, any of a group of guanidine phosphates that occur in muscle and can be used to regenerate ATP from ADP during muscular contraction." [GOC:jl, ISBN:0198506732]


id: GO:0042397
name: phosphagen catabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the breakdown of phosphagen, any of a group of guanidine phosphates that occur in muscle and can be used to regenerate ATP from ADP during muscular contraction." [GOC:jl, ISBN:0198506732]


id: GO:0042398
name: cellular modified amino acid biosynthetic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of compounds derived from amino acids, organic acids containing one or more amino substituents." [CHEBI:83821, GOC:ai]


id: GO:0042399
name: ectoine metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving ectoine (1,4,5,6-tetrahydro-2-methyl-4-pyrimidinecarboxylic acid), a tetrahydropyrimidine commonly synthesized by halophilic bacteria." [GOC:jl, PMID:11823218]


id: GO:0042400
name: ectoine catabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the breakdown of ectoine (1,4,5,6-tetrahydro-2-methyl-4-pyrimidinecarboxylic acid), a tetrahydropyrimidine commonly synthesized by halophilic bacteria." [GOC:jl, PMID:11823218]


id: GO:0042401
name: cellular biogenic amine biosynthetic process
namespace: biological_process
def:
  "The chemical reactions and pathways occurring at the level of individual cells resulting in the formation of any of a group of naturally occurring, biologically active amines, such as norepinephrine, histamine, and serotonin, many of which act as neurotransmitters." [GOC:jl, ISBN:0395825172]


id: GO:0042402
name: cellular biogenic amine catabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways occurring at the level of individual cells resulting in the breakdown of biogenic amines, any of a group of naturally occurring, biologically active amines, such as norepinephrine, histamine, and serotonin, many of which act as neurotransmitters." [GOC:go_curators, GOC:jl, ISBN:0198506732]


id: GO:0042403
name: thyroid hormone metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving any of the compounds secreted by the thyroid gland, largely thyroxine and triiodothyronine." [GOC:jl, ISBN:0198506732]


id: GO:0042404
name: thyroid hormone catabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the breakdown of any of the compounds secreted by the thyroid gland, largely thyroxine and triiodothyronine." [GOC:jl, ISBN:0198506732]


id: GO:0042406
name: extrinsic component of endoplasmic reticulum membrane
namespace: cellular_component
def:
  "The component of the endoplasmic reticulum membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:curators, GOC:dos]


id: GO:0042407
name: cristae formation
namespace: biological_process
def:
  "The assembly of cristae, the inwards folds of the inner mitochondrial membrane." [GOC:jl, ISBN:0198506732]


id: GO:0042408
name: obsolete myrcene/(E)-beta-ocimene synthase activity
namespace: molecular_function
def:
  "OBSOLETE. Catalysis of the conversion of geranyl diphosphate (GPP) into the acyclic monoterpenes beta-myrcene, (E)-beta-ocimene, and other minor cyclic monoterpenes." [GOC:cr, PMID:10700382]


id: GO:0042409
name: caffeoyl-CoA O-methyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: S-adenosyl-L-methionine + caffeoyl-CoA = S-adenosyl-L-homocysteine + feruloyl-CoA." [EC:2.1.1.104]


id: GO:0042410
name: 6-carboxyhexanoate-CoA ligase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: ATP + CoA + pimelate = AMP + diphosphate + H(+) + pimelyl-CoA." [EC:6.2.1.14, RHEA:14784]


id: GO:0042412
name: taurine biosynthetic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of taurine (2-aminoethanesulfonic acid), a sulphur-containing amino acid derivative important in the metabolism of fats." [GOC:jl, ISBN:0198600461]


id: GO:0042413
name: carnitine catabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the breakdown of carnitine (hydroxy-trimethyl aminobutyric acid), a compound that participates in the transfer of acyl groups across the inner mitochondrial membrane." [GOC:jl, ISBN:0198506732]


id: GO:0042414
name: epinephrine metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving epinephrine, a hormone produced by the medulla of the adrenal glands that increases heart activity, improves the power and prolongs the action of muscles, and increases the rate and depth of breathing. It is synthesized by the methylation of norepinephrine." [GOC:jl, ISBN:0192801023, ISBN:0198506732]


id: GO:0042415
name: norepinephrine metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving norepinephrine, a hormone secreted by the adrenal medulla, and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts in the central nervous system. It is also the demethylated biosynthetic precursor of epinephrine." [GOC:jl, ISBN:0198506732]


id: GO:0042416
name: dopamine biosynthetic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of dopamine, a catecholamine neurotransmitter and a metabolic precursor of noradrenaline and adrenaline." [GOC:jl, ISBN:0198506732]


id: GO:0042417
name: dopamine metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving dopamine, a catecholamine neurotransmitter and a metabolic precursor of noradrenaline and adrenaline." [GOC:jl, ISBN:0198506732]


id: GO:0042418
name: epinephrine biosynthetic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of epinephrine, a hormone produced by the medulla of the adrenal glands that increases heart activity, improves the power and prolongs the action of muscles, and increases the rate and depth of breathing. It is synthesized by the methylation of norepinephrine." [GOC:jl, ISBN:0192801023, ISBN:0198506732]


id: GO:0042419
name: epinephrine catabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the breakdown of epinephrine, a hormone produced by the medulla of the adrenal glands that increases heart activity, improves the power and prolongs the action of muscles, and increases the rate and depth of breathing. It is synthesized by the methylation of norepinephrine." [GOC:jl, ISBN:0192801023, ISBN:0198506732]


id: GO:0042420
name: dopamine catabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the breakdown of dopamine, a catecholamine neurotransmitter and a metabolic precursor of noradrenaline and adrenaline." [GOC:jl, ISBN:0198506732]


id: GO:0042421
name: norepinephrine biosynthetic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of norepinephrine, a hormone secreted by the adrenal medulla, and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts in the central nervous system. It is also the demethylated biosynthetic precursor of epinephrine." [GOC:jl, ISBN:0198506732]


id: GO:0042422
name: norepinephrine catabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the breakdown of norepinephrine, a hormone secreted by the adrenal medulla, and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts in the central nervous system. It is also the demethylated biosynthetic precursor of epinephrine." [GOC:jl, ISBN:0198506732]


id: GO:0042423
name: catecholamine biosynthetic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of any of a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine." [GOC:jl, ISBN:0198506732]


id: GO:0042424
name: catecholamine catabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the breakdown of any of a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine." [GOC:jl, ISBN:0198506732]


id: GO:0042425
name: choline biosynthetic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of choline (2-hydroxyethyltrimethylammonium), an amino alcohol that occurs widely in living organisms as a constituent of certain types of phospholipids and in the neurotransmitter acetylcholine." [GOC:jl, ISBN:0192801023]


id: GO:0042426
name: choline catabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the breakdown of choline (2-hydroxyethyltrimethylammonium), an amino alcohol that occurs widely in living organisms as a constituent of certain types of phospholipids and in the neurotransmitter acetylcholine." [GOC:jl, ISBN:0192801023]


id: GO:0042427
name: serotonin biosynthetic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of serotonin (5-hydroxytryptamine), a monoamine neurotransmitter occurring in the peripheral and central nervous systems, also having hormonal properties." [GOC:jl, ISBN:0198506732]


id: GO:0042428
name: serotonin metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving serotonin (5-hydroxytryptamine), a monoamine neurotransmitter occurring in the peripheral and central nervous systems, also having hormonal properties." [GOC:jl, ISBN:0198506732]


id: GO:0042429
name: serotonin catabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the breakdown of serotonin (5-hydroxytryptamine), a monoamine neurotransmitter occurring in the peripheral and central nervous systems, also having hormonal properties." [GOC:jl, ISBN:0198506732]


id: GO:0042430
name: indole-containing compound metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving compounds that contain an indole (2,3-benzopyrrole) skeleton." [CHEBI:24828, GOC:jl, GOC:mah]


id: GO:0042431
name: indole metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving indole (2,3-benzopyrrole), the basis of many biologically active substances (e.g. serotonin, tryptophan)." [CHEBI:35581, GOC:jl]


id: GO:0042432
name: indole biosynthetic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of indole (2,3-benzopyrrole), the basis of many biologically active substances (e.g. serotonin, tryptophan)." [CHEBI:35581, GOC:jl]


id: GO:0042433
name: indole catabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the breakdown of indole (2,3-benzopyrrole), the basis of many biologically active substances (e.g. serotonin, tryptophan)." [CHEBI:35581, GOC:jl]


id: GO:0042435
name: indole-containing compound biosynthetic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of compounds that contain an indole (2,3-benzopyrrole) skeleton." [CHEBI:24828, GOC:jl]


id: GO:0042436
name: indole-containing compound catabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the breakdown of compounds that contain an indole (2,3-benzopyrrole) skeleton." [CHEBI:24828, GOC:jl]


id: GO:0042437
name: indoleacetic acid catabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the breakdown of indole-3-acetic acid, a compound which functions as a growth regulator in plants." [GOC:jl]


id: GO:0042438
name: melanin biosynthetic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of melanins, pigments largely of animal origin. High molecular weight polymers of indole quinone, they are irregular polymeric structures and are divided into three groups: allomelanins in the plant kingdom and eumelanins and phaeomelanins in the animal kingdom." [CHEBI:25179, GOC:curators]


id: GO:0042439
name: ethanolamine-containing compound metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving ethanolamine (2-aminoethanol) and compounds derived from it." [CHEBI:16000, GOC:mah]


id: GO:0042440
name: pigment metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving pigment, any general or particular coloring matter in living organisms, e.g. melanin." [GOC:jl, ISBN:0198506732]


id: GO:0042441
name: eye pigment metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving eye pigments, any general or particular coloring matter in living organisms, found or utilized in the eye." [GOC:ai]


id: GO:0042442
name: melatonin catabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the breakdown of melatonin (N-acetyl-5-methoxytryptamine)." [GOC:jl]


id: GO:0042443
name: phenylethylamine metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving phenylethylamine, an amine with pharmacological properties similar to those of amphetamine, occurs naturally as a neurotransmitter in the brain, and is present in chocolate and oil of bitter almonds." [GOC:jl, ISBN:0395825172]


id: GO:0042444
name: phenylethylamine biosynthetic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of phenylethylamine, an amine with pharmacological properties similar to those of amphetamine, occurs naturally as a neurotransmitter in the brain, and is present in chocolate and oil of bitter almonds." [GOC:jl, ISBN:0395825172]


id: GO:0042445
name: hormone metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving any hormone, naturally occurring substances secreted by specialized cells that affects the metabolism or behavior of other cells possessing functional receptors for the hormone." [CHEBI:24621, GOC:jl]


id: GO:0042446
name: hormone biosynthetic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of any hormone, naturally occurring substances secreted by specialized cells that affects the metabolism or behavior of other cells possessing functional receptors for the hormone." [CHEBI:24621, GOC:jl]


id: GO:0042447
name: hormone catabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the breakdown of any hormone, naturally occurring substances secreted by specialized cells that affects the metabolism or behavior of other cells possessing functional receptors for the hormone." [CHEBI:24621, GOC:jl]


id: GO:0042448
name: progesterone metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving progesterone, a steroid hormone produced in the ovary which prepares and maintains the uterus for pregnancy. Also found in plants." [GOC:jl, http://www.cogsci.princeton.edu/]


id: GO:0042450
name: arginine biosynthetic process via ornithine
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of arginine (2-amino-5-guanidinopentanoic acid) via the intermediate compound ornithine." [GOC:jl]


id: GO:0042451
name: purine nucleoside biosynthetic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of any purine nucleoside, one of a family of organic molecules consisting of a purine base covalently bonded to a sugar ribose (a ribonucleoside) or deoxyribose (a deoxyribonucleoside)." [GOC:go_curators]


id: GO:0042452
name: deoxyguanosine biosynthetic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of deoxyguanosine, a nucleoside consisting of the base guanine and the sugar deoxyribose." [CHEBI:17172, GOC:jl]


id: GO:0042453
name: deoxyguanosine metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving deoxyguanosine, a nucleoside consisting of the base guanine and the sugar deoxyribose." [CHEBI:17172, GOC:jl]


id: GO:0042454
name: ribonucleoside catabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the breakdown of any ribonucleoside, a nucleoside in which purine or pyrimidine base is linked to a ribose (beta-D-ribofuranose) molecule." [CHEBI:18254, GOC:jl]


id: GO:0042455
name: ribonucleoside biosynthetic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of any ribonucleoside, a nucleoside in which purine or pyrimidine base is linked to a ribose (beta-D-ribofuranose) molecule." [CHEBI:18254, GOC:jl]


id: GO:0042457
name: ethylene catabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the breakdown of ethylene (C2-H4, ethene), a simple hydrocarbon gas that can function in plants as a growth regulator." [GOC:jl, ISBN:0387969845]


id: GO:0042458
name: nopaline catabolic process to proline
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the breakdown of nopaline into other compounds, including proline." [GOC:go_curators]


id: GO:0042459
name: octopine catabolic process to proline
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the breakdown of octopine into other compounds, including proline." [GOC:go_curators]


id: GO:0042461
name: photoreceptor cell development
namespace: biological_process
def:
  "Development of a photoreceptor, a cell that responds to incident electromagnetic radiation, particularly visible light." [GOC:go_curators]


id: GO:0042462
name: eye photoreceptor cell development
namespace: biological_process
def:
  "Development of a photoreceptor, a sensory cell in the eye that reacts to the presence of light. They usually contain a pigment that undergoes a chemical change when light is absorbed, thus stimulating a nerve." [GOC:jl, ISBN:0192800981]


id: GO:0042463
name: ocellus photoreceptor cell development
namespace: biological_process
def:
  "Development of photoreceptors, sensory cells that react to the presence of light, found in the ocellus." [GOC:jl, ISBN:0192800981, PMID:11542766]


id: GO:0042464
name: dosage compensation by hypoactivation of X chromosome
namespace: biological_process
def:
  "Compensating for the two-fold variation in X:autosome chromosome ratios between sexes by an inactivation of a proportion of genes on both of the X chromosomes of the XX sex, leading to a decrease, of half, of the levels of gene expression from these chromosomes. An example of this process is found in Caenorhabditis elegans." [GOC:jl, PMID:11102361]


id: GO:0042465
name: kinesis
namespace: biological_process
def:
  "The movement of a cell or organism in response to a stimulus in which the rate of movement depends on the intensity (rather than the direction) of the stimulus." [GOC:jl, ISBN:0192801023]


id: GO:0042466
name: chemokinesis
namespace: biological_process
def:
  "A response by a motile cell to a soluble chemical that involves an increase or decrease in speed (positive or negative orthokinesis) or of frequency of movement or a change in the frequency or magnitude of turning behavior (klinokinesis)." [GOC:jl, PMID:2073411]


id: GO:0042467
name: orthokinesis
namespace: biological_process
def:
  "The movement of a cell or organism in response to a stimulus in which the speed or frequency of movement is increased or decreased." [GOC:jl, PMID:8207088]


id: GO:0042468
name: klinokinesis
namespace: biological_process
def:
  "The movement of a cell or organism in response to a stimulus in which the frequency or magnitude of turning behavior is altered." [GOC:jl, PMID:2790068]


id: GO:0042470
name: melanosome
namespace: cellular_component
def:
  "A tissue-specific, membrane-bounded cytoplasmic organelle within which melanin pigments are synthesized and stored. Melanosomes are synthesized in melanocyte cells." [GOC:jl, PMID:11584301]


id: GO:0042471
name: ear morphogenesis
namespace: biological_process
def:
  "The process in which the anatomical structures of the ear are generated and organized. The ear is the sense organ in vertebrates that is specialized for the detection of sound, and the maintenance of balance. Includes the outer ear and middle ear, which collect and transmit sound waves; and the inner ear, which contains the organs of balance and (except in fish) hearing. Also includes the pinna, the visible part of the outer ear, present in some mammals." [GOC:jl, ISBN:0192801023]


id: GO:0042472
name: inner ear morphogenesis
namespace: biological_process
def:
  "The process in which the anatomical structures of the inner ear are generated and organized. The inner ear is the structure in vertebrates that contains the organs of balance and hearing. It consists of soft hollow sensory structures (the membranous labyrinth) containing fluid (endolymph) surrounded by fluid (perilymph) and encased in a bony cavity (the bony labyrinth). It consists of two chambers, the sacculus and utriculus, from which arise the cochlea and semicircular canals respectively." [GOC:jl, ISBN:0192801023]


id: GO:0042473
name: outer ear morphogenesis
namespace: biological_process
def:
  "The process in which the anatomical structures of the outer ear are generated and organized. The outer ear is the part of the ear external to the tympanum (eardrum). It consists of a tube (the external auditory meatus) that directs sound waves on to the tympanum, and may also include the external pinna, which extends beyond the skull." [GOC:jl, ISBN:0192801023]


id: GO:0042474
name: middle ear morphogenesis
namespace: biological_process
def:
  "The process in which the anatomical structures of the middle ear are generated and organized. The middle ear is the air-filled cavity within the skull of vertebrates that lies between the outer ear and the inner ear. It is linked to the pharynx (and therefore to outside air) via the Eustachian tube and in mammals contains the three ear ossicles, which transmit auditory vibrations from the outer ear (via the tympanum) to the inner ear (via the oval window)." [GOC:jl, ISBN:0192801023]


id: GO:0042475
name: odontogenesis of dentin-containing tooth
namespace: biological_process
def:
  "The process whose specific outcome is the progression of a dentin-containing tooth over time, from its formation to the mature structure. A dentin-containing tooth is a hard, bony organ borne on the jaw or other bone of a vertebrate, and is composed mainly of dentin, a dense calcified substance, covered by a layer of enamel." [GOC:cjm, GOC:mah, GOC:mtg_sensu, PMID:10333884, PMID:15355794]


id: GO:0042476
name: odontogenesis
namespace: biological_process
def:
  "The process whose specific outcome is the progression of a tooth or teeth over time, from formation to the mature structure(s). A tooth is any hard bony, calcareous, or chitinous organ found in the mouth or pharynx of an animal and used in procuring or masticating food." [GOC:jl, GOC:mah]


id: GO:0042478
name: regulation of eye photoreceptor cell development
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of eye photoreceptor development." [GOC:jl]


id: GO:0042479
name: positive regulation of eye photoreceptor cell development
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of eye photoreceptor development." [GOC:jl]


id: GO:0042480
name: negative regulation of eye photoreceptor cell development
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of eye photoreceptor development." [GOC:jl]


id: GO:0042481
name: regulation of odontogenesis
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of the formation and development of a tooth or teeth." [GOC:jl]


id: GO:0042482
name: positive regulation of odontogenesis
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of the formation and development of a tooth or teeth." [GOC:jl]


id: GO:0042483
name: negative regulation of odontogenesis
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of the formation and development of a tooth or teeth." [GOC:jl]


id: GO:0042487
name: regulation of odontogenesis of dentin-containing tooth
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of the formation and development of teeth, the hard, bony appendages which are borne on the jaws, or on other bones in the walls of the mouth or pharynx of most vertebrates." [GOC:jl, GOC:mtg_sensu, PMID:15355794]


id: GO:0042488
name: positive regulation of odontogenesis of dentin-containing tooth
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of the formation and development of teeth, the hard, bony appendages that are borne on the jaws, or on other bones in the walls of the mouth or pharynx of most vertebrates." [dictyBase_REF:2530, GOC:jl, PMID:15355794]


id: GO:0042489
name: negative regulation of odontogenesis of dentin-containing tooth
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of the formation and development of teeth, the hard, bony appendages which are borne on the jaws, or on other bones in the walls of the mouth or pharynx." [GOC:jl, GOC:mtg_sensu, PMID:15355794]


id: GO:0042490
name: mechanoreceptor differentiation
namespace: biological_process
def:
  "The process in which a relatively unspecialized cell acquires specialized features of a mechanoreceptor, a cell specialized to transduce mechanical stimuli and relay that information centrally in the nervous system." [CL:0000199, GOC:jl]


id: GO:0042491
name: auditory receptor cell differentiation
namespace: biological_process
def:
  "The process in which a relatively unspecialized cell acquires specialized features of an auditory hair cell." [CL:0000201, GOC:jl]


id: GO:0042492
name: gamma-delta T cell differentiation
namespace: biological_process
def:
  "The process in which a relatively unspecialized hemopoietic cell acquires specialized features of a gamma-delta T cell. A gamma-delta T cell is a T cell that expresses a gamma-delta T cell receptor complex." [CL:0000798, GOC:jl]


id: GO:0042493
name: response to drug
namespace: biological_process
def:
  "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a drug stimulus. A drug is a substance used in the diagnosis, treatment or prevention of a disease." [GOC:jl]


id: GO:0042494
name: detection of bacterial lipoprotein
namespace: biological_process
def:
  "The series of events in which a bacterial lipoprotein stimulus is received by a cell and converted into a molecular signal. Bacterial lipoproteins are lipoproteins characterized by the presence of conserved sequence motifs called pathogen-associated molecular patterns (PAMPs)." [GOC:jl, PMID:12077222]


id: GO:0042495
name: detection of triacyl bacterial lipopeptide
namespace: biological_process
def:
  "The series of events in which a triacylated bacterial lipoprotein stimulus is received by a cell and converted into a molecular signal. Triacylated bacterial lipoproteins are lipopeptides of bacterial origin containing a nonprotein moiety consisting of three acyl groups." [GOC:add, PMID:12077222, PMID:12524386, PMID:2757794]


id: GO:0042496
name: detection of diacyl bacterial lipopeptide
namespace: biological_process
def:
  "The series of events in which a diacylated bacterial lipopeptide stimulus is received by a cell and converted into a molecular signal. Diacylated bacterial lipoproteins are lipopeptides of bacterial origin containing a nonprotein moiety consisting of two acyl groups." [GOC:add, PMID:12077222, PMID:12524386, PMID:2757794]


id: GO:0042497
name: triacyl lipopeptide binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with a lipopeptide containing a nonprotein moiety consisting of three acyl groups." [GOC:add, PMID:12077222, PMID:12524386, PMID:2757794]


id: GO:0042498
name: diacyl lipopeptide binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with a lipopeptide containing a nonprotein moiety consisting of two acyl groups." [GOC:add, PMID:12077222, PMID:12524386, PMID:2757794]


id: GO:0042499
name: obsolete signal peptide peptidase activity
namespace: molecular_function
def:
  "OBSOLETE. Catalysis of the intramembrane proteolysis of a signal peptide, following its removal from a preprotein." [PMID:12077416]


id: GO:0042500
name: aspartic endopeptidase activity, intramembrane cleaving
namespace: molecular_function
def:
  "Catalysis of the hydrolysis of nonterminal peptide bonds in a polypeptide chain, occurring within a membrane." [GOC:jl, ISBN:0198506732]


id: GO:0042501
name: serine phosphorylation of STAT protein
namespace: biological_process
def:
  "The process of introducing a phosphate group to a serine residue of a STAT (Signal Transducer and Activator of Transcription) protein." [GOC:jl, PMID:10918594]


id: GO:0042502
name: tyrosine phosphorylation of Stat2 protein
namespace: biological_process
def:
  "The process of introducing a phosphate group to a tyrosine residue of a Stat2 protein." [GOC:jl, PMID:10918594]


id: GO:0042503
name: tyrosine phosphorylation of Stat3 protein
namespace: biological_process
def:
  "The process of introducing a phosphate group to a tyrosine residue of a Stat3 protein." [GOC:jl, PMID:11426647]


id: GO:0042504
name: tyrosine phosphorylation of Stat4 protein
namespace: biological_process
def:
  "The process of introducing a phosphate group to a tyrosine residue of a Stat4 protein." [GOC:jl, PMID:11426647]


id: GO:0042505
name: tyrosine phosphorylation of Stat6 protein
namespace: biological_process
def:
  "The process of introducing a phosphate group to a tyrosine residue of a Stat6 protein." [GOC:jl, PMID:11426647]


id: GO:0042506
name: tyrosine phosphorylation of Stat5 protein
namespace: biological_process
def:
  "The process of introducing a phosphate group to a tyrosine residue of a Stat5 protein." [GOC:jl, PMID:11426647]


id: GO:0042507
name: tyrosine phosphorylation of Stat7 protein
namespace: biological_process
def:
  "The process of introducing a phosphate group to a tyrosine residue of a Stat7 protein." [GOC:jl, PMID:11426647]


id: GO:0042508
name: tyrosine phosphorylation of Stat1 protein
namespace: biological_process
def:
  "The process of introducing a phosphate group to a tyrosine residue of a Stat1 protein." [GOC:jl, PMID:10918594]


id: GO:0042509
name: regulation of tyrosine phosphorylation of STAT protein
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a STAT (Signal Transducer and Activator of Transcription) protein." [GOC:jl, PMID:11426647]


id: GO:0042510
name: regulation of tyrosine phosphorylation of Stat1 protein
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of introducing a phosphate group to a tyrosine residue of a Stat1 protein." [GOC:jl, PMID:10918594]


id: GO:0042511
name: positive regulation of tyrosine phosphorylation of Stat1 protein
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a Stat1 protein." [GOC:jl, PMID:10918594]


id: GO:0042512
name: negative regulation of tyrosine phosphorylation of Stat1 protein
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a Stat1 protein." [GOC:jl, PMID:10918594]


id: GO:0042513
name: regulation of tyrosine phosphorylation of Stat2 protein
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of introducing a phosphate group to a tyrosine residue of a Stat2 protein." [GOC:jl, PMID:10918594]


id: GO:0042514
name: negative regulation of tyrosine phosphorylation of Stat2 protein
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a Stat2 protein." [GOC:jl, PMID:10918594]


id: GO:0042515
name: positive regulation of tyrosine phosphorylation of Stat2 protein
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a Stat2 protein." [GOC:jl, PMID:10918594]


id: GO:0042516
name: regulation of tyrosine phosphorylation of Stat3 protein
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of introducing a phosphate group to a tyrosine residue of a Stat3 protein." [GOC:jl, PMID:11426647]


id: GO:0042517
name: positive regulation of tyrosine phosphorylation of Stat3 protein
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a Stat3 protein." [GOC:jl, PMID:11426647]


id: GO:0042518
name: negative regulation of tyrosine phosphorylation of Stat3 protein
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a Stat3 protein." [GOC:jl, PMID:11426647]


id: GO:0042519
name: regulation of tyrosine phosphorylation of Stat4 protein
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of introducing a phosphate group to a tyrosine residue of a Stat4 protein." [GOC:jl, PMID:11426647]


id: GO:0042520
name: positive regulation of tyrosine phosphorylation of Stat4 protein
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a Stat4 protein." [GOC:jl, PMID:11426647]


id: GO:0042521
name: negative regulation of tyrosine phosphorylation of Stat4 protein
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a Stat4 protein." [GOC:jl, PMID:11426647]


id: GO:0042522
name: regulation of tyrosine phosphorylation of Stat5 protein
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of introducing a phosphate group to a tyrosine residue of a Stat5 protein." [GOC:jl, PMID:11426647]


id: GO:0042523
name: positive regulation of tyrosine phosphorylation of Stat5 protein
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a Stat5 protein." [GOC:jl, PMID:11426647]


id: GO:0042524
name: negative regulation of tyrosine phosphorylation of Stat5 protein
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a Stat5 protein." [GOC:jl, PMID:11426647]


id: GO:0042525
name: regulation of tyrosine phosphorylation of Stat6 protein
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of introducing a phosphate group to a tyrosine residue of a Stat6 protein." [GOC:jl, PMID:11426647]


id: GO:0042526
name: positive regulation of tyrosine phosphorylation of Stat6 protein
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a Stat6 protein." [GOC:jl, PMID:11426647]


id: GO:0042527
name: negative regulation of tyrosine phosphorylation of Stat6 protein
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a Stat6 protein." [GOC:jl, PMID:11426647]


id: GO:0042528
name: regulation of tyrosine phosphorylation of Stat7 protein
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of introducing a phosphate group to a tyrosine residue of a Stat7 protein." [GOC:jl, PMID:11426647]


id: GO:0042529
name: positive regulation of tyrosine phosphorylation of Stat7 protein
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a Stat7 protein." [GOC:jl, PMID:11426647]


id: GO:0042530
name: negative regulation of tyrosine phosphorylation of Stat7 protein
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a Stat7 protein." [GOC:jl, PMID:11426647]


id: GO:0042531
name: positive regulation of tyrosine phosphorylation of STAT protein
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a STAT (Signal Transducer and Activator of Transcription) protein." [GOC:jl, PMID:11426647]


id: GO:0042532
name: negative regulation of tyrosine phosphorylation of STAT protein
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a STAT (Signal Transducer and Activator of Transcription) protein." [GOC:jl, PMID:11426647]


id: GO:0042533
name: tumor necrosis factor biosynthetic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of tumor necrosis factor, an inflammatory cytokine produced by macrophages/monocytes during acute inflammation and which is responsible for a diverse range of signaling events within cells, leading to necrosis or apoptosis." [GOC:jl, PMID:10891884]


id: GO:0042534
name: regulation of tumor necrosis factor biosynthetic process
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of tumor necrosis factor, an inflammatory cytokine produced by macrophages/monocytes during acute inflammation and which is responsible for a diverse range of signaling events within cells, leading to necrosis or apoptosis." [GOC:jl, PMID:10891884]


id: GO:0042535
name: positive regulation of tumor necrosis factor biosynthetic process
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of tumor necrosis factor, an inflammatory cytokine produced by macrophages/monocytes during acute inflammation and which is responsible for a diverse range of signaling events within cells, leading to necrosis or apoptosis." [GOC:jl, PMID:10891884]


id: GO:0042536
name: negative regulation of tumor necrosis factor biosynthetic process
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of tumor necrosis factor, an inflammatory cytokine produced by macrophages/monocytes during acute inflammation and which is responsible for a diverse range of signaling events within cells, leading to necrosis or apoptosis." [GOC:jl, PMID:10891884]


id: GO:0042537
name: benzene-containing compound metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving benzene, C6H6, a volatile, very inflammable liquid, contained in the naphtha produced by the destructive distillation of coal, from which it is separated by fractional distillation, or any of its derivatives." [CHEBI:22712, GOC:jl]


id: GO:0042538
name: hyperosmotic salinity response
namespace: biological_process
def:
  "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, an increase in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment." [GOC:jl]


id: GO:0042539
name: hypotonic salinity response
namespace: biological_process
def:
  "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, a decrease in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment." [GOC:jl]


id: GO:0042540
name: hemoglobin catabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the breakdown of hemoglobin, an oxygen carrying, conjugated protein containing four heme groups and globin; especially, the proteolytic cleavage of hemoglobin to yield free heme, peptides, and amino acids." [CHEBI:35143, GOC:jl, GOC:mb]


id: GO:0042541
name: hemoglobin biosynthetic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of hemoglobin, an oxygen carrying, conjugated protein containing four heme groups and globin." [CHEBI:35143, GOC:jl]


id: GO:0042542
name: response to hydrogen peroxide
namespace: biological_process
def:
  "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydrogen peroxide (H2O2) stimulus." [GOC:jl]


id: GO:0042544
name: melibiose biosynthetic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of melibiose, the disaccharide 6-O-alpha-D-galactopyranosyl-D-glucose." [GOC:jl, ISBN:0198506732]


id: GO:0042545
name: cell wall modification
namespace: biological_process
def:
  "The series of events leading to chemical and structural alterations of an existing cell wall that can result in loosening, increased extensibility or disassembly." [GOC:jl]


id: GO:0042546
name: cell wall biogenesis
namespace: biological_process
def:
  "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cell wall. Includes biosynthesis of constituent macromolecules, such as proteins and polysaccharides, and those macromolecular modifications that are involved in synthesis or assembly of the cellular component. A cell wall is the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis." [GOC:jl, GOC:mah, GOC:mtg_sensu, ISBN:0198506732]


id: GO:0042547
name: cell wall modification involved in multidimensional cell growth
namespace: biological_process
def:
  "The series of events resulting in chemical or structural changes to existing cell walls and contribute to multidimensional cell growth." [GOC:dph, GOC:jl, GOC:tb]


id: GO:0042548
name: regulation of photosynthesis, light reaction
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of the light-dependent reaction of photosynthesis." [GOC:jl]


id: GO:0042549
name: photosystem II stabilization
namespace: biological_process
def:
  "The stabilization of the photosystem II protein complex, resulting from the phosphorylation of its structural protein subunits, in a cell actively involved in photosynthesis." [GOC:go_curators]


id: GO:0042550
name: photosystem I stabilization
namespace: biological_process
def:
  "The stabilization of the photosystem I protein complex, resulting from the phosphorylation of its structural protein subunits, in a cell actively involved in photosynthesis." [GOC:go_curators]


id: GO:0042551
name: neuron maturation
namespace: biological_process
def:
  "A developmental process, independent of morphogenetic (shape) change, that is required for a neuron to attain its fully functional state." [GOC:dph, GOC:jl]


id: GO:0042552
name: myelination
namespace: biological_process
def:
  "The process in which myelin sheaths are formed and maintained around neurons. Oligodendrocytes in the brain and spinal cord and Schwann cells in the peripheral nervous system wrap axons with compact layers of their plasma membrane. Adjacent myelin segments are separated by a non-myelinated stretch of axon called a node of Ranvier." [GOC:dgh, GOC:mah]


id: GO:0042554
name: superoxide anion generation
namespace: biological_process
def:
  "The enzymatic generation of superoxide, the superoxide anion O2- (superoxide free radical), or any compound containing this species, by a cell in response to environmental stress, thereby mediating the activation of various stress-inducible signaling pathways." [GOC:jl, PMID:12359750]


id: GO:0042555
name: MCM complex
namespace: cellular_component
def:
  "A hexameric protein complex required for the initiation and regulation of DNA replication." [GOC:jl, PMID:11282021]


id: GO:0042556
name: eukaryotic elongation factor-2 kinase regulator activity
namespace: molecular_function
def:
  "Modulates the activity of the enzyme eukaryotic elongation factor-2 kinase." [GOC:jl, PMID:11904175]


id: GO:0042557
name: eukaryotic elongation factor-2 kinase activator activity
namespace: molecular_function
def:
  "Binds to and increases the activity of the enzyme eukaryotic elongation factor-2 kinase." [GOC:jl, PMID:11904175]


id: GO:0042558
name: pteridine-containing compound metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving any compound containing pteridine (pyrazino(2,3-dipyrimidine)), e.g. pteroic acid, xanthopterin and folic acid." [GOC:jl, ISBN:0198506732]


id: GO:0042559
name: pteridine-containing compound biosynthetic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of any compound containing pteridine (pyrazino(2,3-dipyrimidine)), e.g. pteroic acid, xanthopterin and folic acid." [GOC:jl, ISBN:0198506732]


id: GO:0042560
name: pteridine-containing compound catabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the breakdown of any compound containing pteridine (pyrazino(2,3-dipyrimidine)), e.g. pteroic acid, xanthopterin and folic acid." [GOC:jl, ISBN:0198506732]


id: GO:0042561
name: alpha-amyrin synthase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: (S)-2,3-epoxysqualene = alpha-amyrin. This reaction is a cyclization and rearrangement of (S)-2,3-epoxysqualene (2,3-oxidosqualene) into alpha-amyrin." [GOC:jl, MetaCyc:RXN-8434, PMID:10848960]


id: GO:0042562
name: hormone binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with any hormone, naturally occurring substances secreted by specialized cells that affect the metabolism or behavior of other cells possessing functional receptors for the hormone." [CHEBI:24621, GOC:jl]


id: GO:0042563
name: importin alpha-subunit nuclear export complex
namespace: cellular_component
def:
  "A protein complex which usually consists of three components, e.g. in Xenopus, the importin alpha-subunit/CAS/Ran, and which functions to shuttle the importin alpha-subunit out of the nucleus through the nuclear pore." [GOC:jl, PMID:9323123, PMID:9323134]


id: GO:0042564
name: NLS-dependent protein nuclear import complex
namespace: cellular_component
def:
  "A protein complex which usually consists of three components, e.g. in Xenopus, the importin alpha and beta-subunits and any protein which has a nuclear localization sequence (NLS). The complex acts to import proteins with an NLS into the nucleus through a nuclear pore." [GOC:jl, PMID:9323123, PMID:9323134]


id: GO:0042565
name: RNA nuclear export complex
namespace: cellular_component
def:
  "A complex which usually consists of three components, e.g. in Xenopus and yeast, the export receptor CRM1 (also known as exportin 1), the Ran protein and any RNA with a nuclear export sequence (NES). The complex acts to export RNA molecules with a NES from the nucleus through a nuclear pore." [GOC:jl, PMID:9323123]


id: GO:0042566
name: hydrogenosome
namespace: cellular_component
def:
  "A spherical, membrane-bounded organelle found in some anaerobic protozoa, which participates in ATP and molecular hydrogen formation." [GOC:jl, PMID:11197234, PMID:11293569]


id: GO:0042567
name: insulin-like growth factor ternary complex
namespace: cellular_component
def:
  "A complex of three proteins, which in animals is approximately 150kDa and consists of the insulin-like growth factor (IGF), the insulin-like growth factor binding protein-3 (IGFBP-3), or -5 (IGFBP-5) and an acid-labile subunit (ALS). The complex plays a role in growth and development." [GOC:jl, PMID:12239079]


id: GO:0042568
name: insulin-like growth factor binary complex
namespace: cellular_component
def:
  "A complex of two proteins, which in animals is 50kDa and consists of the insulin-like growth factor (IGF) and one of the insulin-like growth factor binding protein-1 (IGFBP-1), -2 (IGFBP-2), -4 (IGFBP-4) and -6 (IGFBP-6). The complex plays a role in growth and development." [GOC:jl, PMID:12239079]


id: GO:0042571
name: immunoglobulin complex, circulating
namespace: cellular_component
def:
  "An immunoglobulin complex that is secreted into extracellular space and found in mucosal areas or other tissues or circulating in the blood or lymph. In its canonical form, a circulating immunoglobulin complex is composed of two identical heavy chains and two identical light chains, held together by disulfide bonds. Some forms of are polymers of the basic structure and contain additional components such as J-chain and the secretory component." [GOC:add, ISBN:0781735149]


id: GO:0042572
name: retinol metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving retinol, one of the three compounds that makes up vitamin A." [GOC:jl, http://www.indstate.edu/thcme/mwking/vitamins.html, PMID:1924551]


id: GO:0042573
name: retinoic acid metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving retinoic acid, one of the three components that makes up vitamin A." [GOC:jl, http://www.indstate.edu/thcme/mwking/vitamins.html]


id: GO:0042574
name: retinal metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving retinal, a compound that plays an important role in the visual process in most vertebrates. In the retina, retinal combines with opsins to form visual pigments. Retinal is one of the forms of vitamin A." [CHEBI:15035, GOC:curators, ISBN:0198506732]


id: GO:0042575
name: DNA polymerase complex
namespace: cellular_component
def:
  "A protein complex that possesses DNA polymerase activity and is involved in template directed synthesis of DNA." [GOC:jl, PMID:12045093]


id: GO:0042576
name: obsolete aspartyl aminopeptidase activity
namespace: molecular_function
def:
  "OBSOLETE. Catalysis of the release of an N-terminal aspartate or glutamate from a peptide, with a preference for aspartate." [EC:3.4.11.21]


id: GO:0042578
name: phosphoric ester hydrolase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: RPO-R' + H2O = RPOOH + R'H. This reaction is the hydrolysis of any phosphoric ester bond, any ester formed from orthophosphoric acid, O=P(OH)3." [GOC:jl]


id: GO:0042579
name: microbody
namespace: cellular_component
def:
  "Cytoplasmic organelles, spherical or oval in shape, that are bounded by a single membrane and contain oxidative enzymes, especially those utilizing hydrogen peroxide (H2O2)." [ISBN:0198506732]


id: GO:0042580
name: mannosome
namespace: cellular_component
def:
  "A specialised tubular organelle, assembled in hexagonal bundles within an external membrane. Mannosomes are specific to molluscs and are thought to be involved in a general stress reaction." [GOC:jl, PMID:11912051, PMID:9799531]


id: GO:0042581
name: specific granule
namespace: cellular_component
def:
  "Granule with a membranous, tubular internal structure, found primarily in mature neutrophil cells. Most are released into the extracellular fluid. Specific granules contain lactoferrin, lysozyme, vitamin B12 binding protein and elastase." [GOC:jl, ISBN:0721662544, PMID:7334549]


id: GO:0042582
name: azurophil granule
namespace: cellular_component
def:
  "Primary lysosomal granule found in neutrophil granulocytes. Contains a wide range of hydrolytic enzymes and is released into the extracellular fluid." [GOC:jl, PMID:17152095]


id: GO:0042583
name: chromaffin granule
namespace: cellular_component
def:
  "Specialized secretory vesicle found in the cells of adrenal glands and various other organs, which is concerned with the synthesis, storage, metabolism, and secretion of epinephrine and norepinephrine." [GOC:jl, PMID:19158310, PMID:1961743]


id: GO:0042584
name: chromaffin granule membrane
namespace: cellular_component
def:
  "The lipid bilayer surrounding a chromaffin granule, a specialized secretory vesicle found in the cells of adrenal glands and various other organs, which is concerned with the synthesis, storage, metabolism, and secretion of epinephrine and norepinephrine." [GOC:jl]


id: GO:0042585
name: germinal vesicle
namespace: cellular_component
def:
  "The enlarged, fluid filled nucleus of a primary oocyte, the development of which is suspended in prophase I of the first meiotic division between embryohood and sexual maturity." [GOC:jl, GOC:mtg_sensu, PMID:19019837]


id: GO:0042586
name: peptide deformylase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: formyl-L-methionyl peptide + H2O = formate + methionyl peptide." [EC:3.5.1.88, GOC:jl]


id: GO:0042587
name: glycogen granule
namespace: cellular_component
def:
  "Cytoplasmic bead-like structures of animal cells, visible by electron microscope. Each granule is a functional unit with the biosynthesis and catabolism of glycogen being catalyzed by enzymes bound to the granule surface." [GOC:jl, http://148.216.10.83/cellbio/the_mi19.gif, PMID:12179957]


id: GO:0042588
name: zymogen granule
namespace: cellular_component
def:
  "A membrane-bounded, cytoplasmic secretory granule found in enzyme-secreting cells and visible by light microscopy. Contain zymogen, an inactive enzyme precursor, often of a digestive enzyme." [GOC:jl, ISBN:0198506732]


id: GO:0042590
name: antigen processing and presentation of exogenous peptide antigen via MHC class I
namespace: biological_process
def:
  "The process in which an antigen-presenting cell expresses a peptide antigen of exogenous origin on its cell surface in association with an MHC class I protein complex. The peptide antigen is typically, but not always, processed from a whole protein. Class I here refers to classical class I molecules." [GOC:add, ISBN:0781735149, PMID:15771591]


id: GO:0042592
name: homeostatic process
namespace: biological_process
def:
  "Any biological process involved in the maintenance of an internal steady state." [GOC:jl, ISBN:0395825172]


id: GO:0042593
name: glucose homeostasis
namespace: biological_process
def:
  "Any process involved in the maintenance of an internal steady state of glucose within an organism or cell." [GOC:go_curators]


id: GO:0042594
name: response to starvation
namespace: biological_process
def:
  "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a starvation stimulus, deprivation of nourishment." [GOC:go_curators]


id: GO:0042595
name: behavioral response to starvation
namespace: biological_process
def:
  "Any process that results in a change in the behavior of an organism as a result of deprivation of nourishment." [GOC:go_curators]


id: GO:0042597
name: periplasmic space
namespace: cellular_component
def:
  "The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or cytoplasmic membrane and cell wall (Fungi and Gram-positive Bacteria)." [GOC:go_curators, GOC:md]


id: GO:0042598
name: obsolete vesicular fraction
namespace: cellular_component
def:
  "OBSOLETE: Any of the small, heterogeneous, artifactual, vesicular particles that are formed when some cells are homogenized." [GOC:jl]


id: GO:0042599
name: lamellar body
namespace: cellular_component
def:
  "A membrane-bounded organelle, specialized for the storage and secretion of various substances (surfactant phospholipids, glycoproteins and acid phosphates) which are arranged in the form of tightly packed, concentric, membrane sheets or lamellae. Has some similar properties to, but is distinct from, a lysosome." [GOC:cjm, GOC:jl, http://en.wikipedia.org/wiki/Lamellar_granule, PMID:12243725]


id: GO:0042600
name: chorion
namespace: cellular_component
def:
  "A protective, noncellular membrane that surrounds the eggs of various animals including insects and fish." [GOC:jl, ISBN:0721662544]


id: GO:0042601
name: endospore-forming forespore
namespace: cellular_component
def:
  "Portion of the cell formed during the process of bacterial sporulation that will ultimately become the core of the endospore. An endospore is a type of dormant cell that is resistant to adverse conditions." [GOC:jl, GOC:mtg_sensu, ISBN:0697286029]


id: GO:0042603
name: capsule
namespace: cellular_component
def:
  "A protective structure surrounding some fungi and bacteria, attached externally to the cell wall and composed primarily of polysaccharides. Capsules are highly organized structures that adhere strongly to cells and cannot be easily removed. Capsules play important roles in pathogenicity, preventing phagocytosis by other cells, adherance, and resistance to dessication." [GOC:mlg]


id: GO:0042608
name: T cell receptor binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with a T cell receptor, the antigen-recognizing receptor on the surface of T cells." [GOC:jl]


id: GO:0042609
name: CD4 receptor binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with a CD4, a receptor found on the surface of T cells, monocytes and macrophages." [GOC:jl, MSH:D015704]


id: GO:0042610
name: CD8 receptor binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with a CD8, a receptor found on the surface of thymocytes and cytotoxic and suppressor T-lymphocytes." [GOC:jl, MSH:D016827]


id: GO:0042611
name: MHC protein complex
namespace: cellular_component
def:
  "A transmembrane protein complex composed of an MHC alpha chain and, in most cases, either an MHC class II beta chain or an invariant beta2-microglobin chain, and with or without a bound peptide, lipid, or polysaccharide antigen." [GOC:add, GOC:jl, ISBN:0781735149, PMID:15928678, PMID:16153240]


id: GO:0042612
name: MHC class I protein complex
namespace: cellular_component
def:
  "A transmembrane protein complex composed of a MHC class I alpha chain and an invariant beta2-microglobin chain, and with or without a bound peptide antigen. Class I here refers to classical class I molecules." [GOC:add, GOC:jl, ISBN:0120781859, ISBN:0781735149]


id: GO:0042613
name: MHC class II protein complex
namespace: cellular_component
def:
  "A transmembrane protein complex composed of an MHC class II alpha and MHC class II beta chain, and with or without a bound peptide or polysaccharide antigen." [GOC:add, GOC:jl, ISBN:0120781859, PMID:15928678]


id: GO:0042614
name: CD70 receptor binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with a CD70, a receptor found on the surface of most activated B cells and some activated T cells." [GOC:jl, ISBN:0120781859]


id: GO:0042615
name: CD154 receptor binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with CD154, a receptor found on the surface of some activated lymphocytes." [GOC:jl, ISBN:0120781859]


id: GO:0042616
name: paclitaxel metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving paclitaxel, an alkaloid compound used as an anticancer treatment." [CHEBI:45863, GOC:jl]


id: GO:0042617
name: paclitaxel biosynthetic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of paclitaxel, an alkaloid compound used as an anticancer treatment." [CHEBI:45863, GOC:jl]


id: GO:0042618
name: poly-hydroxybutyrate metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving poly-hydroxybutyrate (PHB), a polymer of beta-hydroxybutyrate and a common storage material of prokaryotic cells." [GOC:jl, http://biotech.icmb.utexas.edu/search/dict-search.html]


id: GO:0042619
name: poly-hydroxybutyrate biosynthetic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of poly-hydroxybutyrate (PHB), a polymer of beta-hydroxybutyrate and a common storage material of prokaryotic cells." [GOC:jl, http://biotech.icmb.utexas.edu/search/dict-search.html]


id: GO:0042620
name: poly(3-hydroxyalkanoate) metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving poly(3-hydroxyalkanoates), polyesters of 3-hydroxyacids produced as intracellular granules by a large variety of bacteria." [GOC:jl, PMID:9925580]


id: GO:0042621
name: poly(3-hydroxyalkanoate) biosynthetic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of poly(3-hydroxyalkanoates), polyesters of 3-hydroxyacids produced as intracellular granules by a large variety of bacteria." [GOC:jl, PMID:9925580]


id: GO:0042623
name: ATPase activity, coupled
namespace: molecular_function
def:
  "Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction directly drives some other reaction, for example ion transport across a membrane." [EC:3.6.1.3, GOC:jl]


id: GO:0042624
name: ATPase activity, uncoupled
namespace: molecular_function
def:
  "Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction is not directly coupled to any other reaction." [EC:3.6.1.3]


id: GO:0042625
name: ATPase coupled ion transmembrane transporter activity
namespace: molecular_function
def:
  "Catalysis of the transfer of an ion from one side of a membrane to the other, driven by the reaction: ATP + H2O = ADP + phosphate." [EC:3.6.1.3, GOC:jl, GOC:mtg_transport, ISBN:0815340729]


id: GO:0042626
name: ATPase activity, coupled to transmembrane movement of substances
namespace: molecular_function
def:
  "Catalysis of the reaction: ATP + H2O = ADP + phosphate, to directly drive the active transport of a substance across a membrane." [EC:3.6.1.3, GOC:jl]


id: GO:0042627
name: chylomicron
namespace: cellular_component
def:
  "A large lipoprotein particle (diameter 75-1200 nm) composed of a central core of triglycerides and cholesterol surrounded by a protein-phospholipid coating. The proteins include one molecule of apolipoprotein B-48 and may include a variety of apolipoproteins, including APOAs, APOCs and APOE. Chylomicrons are found in blood or lymph and carry lipids from the intestines into other body tissues." [GOC:jl, GOC:rl, http://biotech.icmb.utexas.edu/search/dict-search.html, PMID:10580165]


id: GO:0042628
name: mating plug formation
namespace: biological_process
def:
  "The deposition of a plug of sperm or other gelatinous material into the opening of the vulva by a male at the termination of copulation. Probably acts to prevent subsequent matings by other males." [GOC:jl, http://www.wildcru.org/glossary/glossary.htm, http://www.wormatlas.org/glossaries/cglossary.htm, PMID:11267893]


id: GO:0042629
name: mast cell granule
namespace: cellular_component
def:
  "Coarse, bluish-black staining cytoplasmic granules, bounded by a plasma membrane and found in mast cells and basophils. Contents include histamine, heparin, chondroitin sulfates, chymase and tryptase." [GOC:jl, http://www.ijp-online.com/archives/1969/001/02/r0000-0000tc.htm, PMID:12360215]


id: GO:0042630
name: behavioral response to water deprivation
namespace: biological_process
def:
  "Any process that results in a change in the behavior of an organism as a result of deprivation of water." [GOC:jl]


id: GO:0042631
name: cellular response to water deprivation
namespace: biological_process
def:
  "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of water." [GOC:go_curators]


id: GO:0042632
name: cholesterol homeostasis
namespace: biological_process
def:
  "Any process involved in the maintenance of an internal steady state of cholesterol within an organism or cell." [GOC:go_curators]


id: GO:0042633
name: hair cycle
namespace: biological_process
def:
  "The cyclical phases of growth (anagen), regression (catagen), quiescence (telogen), and shedding (exogen) in the life of a hair; one of the collection or mass of filaments growing from the skin of an animal, and forming a covering for a part of the head or for any part or the whole of the body." [GOC:go_curators, PMID:12230507]


id: GO:0042634
name: regulation of hair cycle
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of the cyclical phases of growth (anagen), regression (catagen), quiescence (telogen), and shedding (exogen) in the life of a hair." [GOC:go_curators, PMID:12230507]


id: GO:0042635
name: positive regulation of hair cycle
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of the cyclical phases of growth (anagen), regression (catagen), quiescence (telogen), and shedding (exogen) in the life of a hair." [GOC:go_curators, PMID:12230507]


id: GO:0042636
name: negative regulation of hair cycle
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of the cyclical phases of growth (anagen), regression (catagen), quiescence (telogen), and shedding (exogen) in the life of a hair." [GOC:go_curators, PMID:12230507]


id: GO:0042637
name: catagen
namespace: biological_process
def:
  "The regression phase of the hair cycle during which cell proliferation ceases, the hair follicle shortens, and an anchored club hair is produced." [PMID:12535193]


id: GO:0042640
name: anagen
namespace: biological_process
def:
  "The growth phase of the hair cycle. Lasts, for example, about 3 to 6 years for human scalp hair." [PMID:12230507]


id: GO:0042649
name: prothylakoid
namespace: cellular_component
def:
  "Underdeveloped thylakoids found in etioplasts, lacking competent photosynthetic membranes. Rapidly develop into mature thylakoids in the presence of light." [GOC:jl, PMID:11532175]


id: GO:0042650
name: prothylakoid membrane
namespace: cellular_component
def:
  "The membrane of prothylakoids, underdeveloped thylakoids found in etioplasts, lacking competent photosynthetic membranes." [GOC:jl, PMID:11532175]


id: GO:0042652
name: mitochondrial respiratory chain complex I, peripheral segment
namespace: cellular_component
def:
  "The peripheral segment of respiratory chain complex I located in the mitochondrion. Respiratory chain complex I is an enzyme of the respiratory chain, consisting of at least 34 polypeptide chains. The electrons of NADH enter the chain at this complex. The complete complex is L-shaped, with a horizontal arm lying in the membrane and a vertical arm that projects into the matrix." [GOC:jid, GOC:mtg_sensu, ISBN:0716749556]


id: GO:0042653
name: mitochondrial respiratory chain complex I, membrane segment
namespace: cellular_component
def:
  "The mitochondrial membrane segment of respiratory chain complex I. Respiratory chain complex I is an enzyme of the respiratory chain, consisting of at least 34 polypeptide chains. The electrons of NADH enter the chain at this complex. The complete complex is L-shaped, with a horizontal arm lying in the membrane and a vertical arm that projects into the matrix." [GOC:jid, GOC:mtg_sensu, ISBN:0716749556]


id: GO:0042655
name: activation of JNKKK activity
namespace: biological_process
def:
  "The initiation of the activity of the inactive enzyme JUN kinase kinase kinase (JNKKK) activity." [GOC:bf]


id: GO:0042657
name: MHC class II protein binding, via lateral surface
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with the lateral surface of major histocompatibility complex class II molecules." [GOC:jl]


id: GO:0042658
name: MHC class II protein binding, via antigen binding groove
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with the antigen binding groove of major histocompatibility complex class II molecules." [GOC:jl]


id: GO:0042661
name: regulation of mesodermal cell fate specification
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of mesoderm cell fate specification." [GOC:go_curators]


id: GO:0042662
name: negative regulation of mesodermal cell fate specification
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of mesoderm cell fate specification." [GOC:go_curators]


id: GO:0042664
name: negative regulation of endodermal cell fate specification
namespace: biological_process
def:
  "Any process that restricts, stops or prevents a cell from specifying into an endoderm cell." [GOC:go_curators]


id: GO:0042666
name: negative regulation of ectodermal cell fate specification
namespace: biological_process
def:
  "Any process that restricts, stops or prevents a cell from specifying into an ectoderm cell." [GOC:go_curators]


id: GO:0042667
name: auditory receptor cell fate specification
namespace: biological_process
def:
  "The process in which a cell becomes capable of differentiating autonomously into an auditory hair cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed." [GOC:go_curators]


id: GO:0042668
name: auditory receptor cell fate determination
namespace: biological_process
def:
  "The process in which a cell becomes capable of differentiating autonomously into an auditory hair cell regardless of its environment; upon determination, the cell fate cannot be reversed." [GOC:go_curators]


id: GO:0042669
name: regulation of auditory receptor cell fate specification
namespace: biological_process
def:
  "Any process that mediates the specification of a cell into an auditory hair cell." [GOC:go_curators]


id: GO:0042670
name: retinal cone cell differentiation
namespace: biological_process
def:
  "The process in which a relatively unspecialized cell acquires the specialized features of a retinal cone cell." [GOC:go_curators]


id: GO:0042671
name: retinal cone cell fate determination
namespace: biological_process
def:
  "The process in which a cell becomes capable of differentiating autonomously into a retinal cone cell regardless of its environment; upon determination, the cell fate cannot be reversed." [GOC:go_curators]


id: GO:0042672
name: retinal cone cell fate specification
namespace: biological_process
def:
  "The process in which a cell becomes capable of differentiating autonomously into a retinal cone cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed." [GOC:go_curators]


id: GO:0042675
name: compound eye cone cell differentiation
namespace: biological_process
def:
  "The process in which a relatively unspecialized cell acquires the specialized features of a compound eye cone cell, a cone-shaped cell, that focuses light in a compound eye." [GOC:mtg_sensu]


id: GO:0042676
name: compound eye cone cell fate commitment
namespace: biological_process
def:
  "The process in which the cone cells of the compound eye, the lens-secreting cells in the ommatidia, adopt pathways of differentiation that lead to the establishment of their distinct cell type." [GOC:mtg_sensu]


id: GO:0042679
name: compound eye cone cell fate specification
namespace: biological_process
def:
  "The process in which a cell becomes capable of differentiating autonomously into a compound eye cone cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed." [GOC:mtg_sensu]


id: GO:0042680
name: compound eye cone cell fate determination
namespace: biological_process
def:
  "The process in which a cell becomes capable of differentiating autonomously into a compound eye cone cell regardless of its environment; upon determination, the cell fate cannot be reversed." [GOC:mtg_sensu]


id: GO:0042682
name: regulation of compound eye cone cell fate specification
namespace: biological_process
def:
  "Any process that mediates the specification of a cell into a compound eye cone cell." [GOC:mtg_sensu]


id: GO:0042683
name: negative regulation of compound eye cone cell fate specification
namespace: biological_process
def:
  "Any process that restricts, stops or prevents a cell from specifying into a compound eye cone cell." [GOC:mtg_sensu]


id: GO:0042684
name: cardioblast cell fate commitment
namespace: biological_process
def:
  "The process in which a cell becomes committed to becoming a cardioblast. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating." [GOC:go_curators]


id: GO:0042685
name: cardioblast cell fate specification
namespace: biological_process
def:
  "The process in which a cell becomes capable of differentiating autonomously into a cardioblast cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating." [GOC:go_curators]


id: GO:0042686
name: regulation of cardioblast cell fate specification
namespace: biological_process
def:
  "Any process that mediates the specification of a cell into a cardioblast. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating." [GOC:go_curators]


id: GO:0042688
name: crystal cell differentiation
namespace: biological_process
def:
  "The process in which a hemocyte precursor cell acquires the characteristics of a crystal cell, a class of cells that contain crystalline inclusions and are involved in the melanization of pathogenic material in the hemolymph." [GOC:bf, http://sdb.bio.purdue.edu/fly/gene/serpent3.htm]


id: GO:0042689
name: regulation of crystal cell differentiation
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of crystal cell differentiation." [GOC:go_curators]


id: GO:0042690
name: negative regulation of crystal cell differentiation
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of crystal cell differentiation." [GOC:go_curators]


id: GO:0042691
name: positive regulation of crystal cell differentiation
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of crystal cell differentiation." [GOC:go_curators]


id: GO:0042692
name: muscle cell differentiation
namespace: biological_process
def:
  "The process in which a relatively unspecialized cell acquires specialized features of a muscle cell." [CL:0000187, GOC:go_curators]


id: GO:0042693
name: muscle cell fate commitment
namespace: biological_process
def:
  "The process in which the cellular identity of muscle cells is acquired and determined." [CL:0000187, GOC:go_curators]


id: GO:0042694
name: muscle cell fate specification
namespace: biological_process
def:
  "The process in which a cell becomes capable of differentiating autonomously into a muscle cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed." [CL:0000187, GOC:go_curators]


id: GO:0042696
name: menarche
namespace: biological_process
def:
  "The beginning of the menstrual cycle; the first menstrual cycle in an individual." [GOC:curators, PMID:16311040]


id: GO:0042697
name: menopause
namespace: biological_process
def:
  "Cessation of menstruation, occurring in (e.g.) the human female usually around the age of 50." [GOC:curators, PMID:18495681]


id: GO:0042698
name: ovulation cycle
namespace: biological_process
def:
  "The type of sexual cycle seen in females, often with physiologic changes in the endometrium that recur at regular intervals during the reproductive years." [ISBN:0721662544]


id: GO:0042701
name: progesterone secretion
namespace: biological_process
def:
  "The regulated release of progesterone, a steroid hormone, by the corpus luteum of the ovary and by the placenta." [GOC:jl, ISBN:0395825172]


id: GO:0042702
name: uterine wall growth
namespace: biological_process
def:
  "The regrowth of the endometrium and blood vessels in the uterus following menstruation, resulting from a rise in progesterone levels." [GOC:jl]


id: GO:0042703
name: menstruation
namespace: biological_process
def:
  "The cyclic, physiologic discharge through the vagina of blood and endometrial tissues from the nonpregnant uterus." [GOC:curators, PMID:8693059]


id: GO:0042704
name: uterine wall breakdown
namespace: biological_process
def:
  "The sloughing of the endometrium and blood vessels during menstruation that results from a drop in progesterone levels." [GOC:dph]


id: GO:0042705
name: ocellus photoreceptor cell differentiation
namespace: biological_process
def:
  "The process in which a relatively unspecialized cell acquires specialized features of a photoreceptor cell found in the ocellus." [GOC:go_curators]


id: GO:0042706
name: eye photoreceptor cell fate commitment
namespace: biological_process
def:
  "The process in which the developmental fate of a cell becomes restricted such that it will develop into an eye photoreceptor cell. A photoreceptor cell is a cell that responds to incident electromagnetic radiation. Different classes of photoreceptor have different spectral sensitivities and express different photosensitive pigments." [GOC:mtg_sensu]


id: GO:0042707
name: ocellus photoreceptor cell fate commitment
namespace: biological_process
def:
  "The process in which the developmental fate of a cell becomes restricted such that it will develop into photoreceptor cell in the ocellus. A photoreceptor cell is a cell that responds to incident electromagnetic radiation. Different classes of photoreceptor have different spectral sensitivities and express different photosensitive pigments." [GOC:mtg_sensu]


id: GO:0042709
name: succinate-CoA ligase complex
namespace: cellular_component
def:
  "A heterodimeric enzyme complex, usually composed of an alpha and beta chain. Functions in the TCA cycle, hydrolyzing succinyl-CoA into succinate and CoA, thereby forming ATP or GTP." [EC:6.2.1.4, EC:6.2.1.5, GOC:jl]


id: GO:0042710
name: biofilm formation
namespace: biological_process
def:
  "A process in which planktonically growing microorganisms grow at a liquid-air interface or on a solid substrate under the flow of a liquid and produce extracellular polymers that facilitate matrix formation, resulting in a change in the organisms' growth rate and gene transcription." [GOC:di, PMID:11932229]


id: GO:0042713
name: sperm ejaculation
namespace: biological_process
def:
  "The expulsion of seminal fluid, thick white fluid containing spermatozoa, from the male genital tract." [GOC:jl, http://www.cogsci.princeton.edu/~wn/]


id: GO:0042714
name: dosage compensation complex assembly
namespace: biological_process
def:
  "The aggregation, arrangement and bonding together of proteins on DNA or RNA to form the complex that mediates dosage compensation on one or more X chromosomes." [GOC:jl, PMID:11102361, PMID:12672493]


id: GO:0042715
namespace: biological_process
name:
  dosage compensation complex assembly involved in dosage compensation by hypoactivation of X chromosome

def:
  "The aggregation, arrangement and bonding together of proteins on DNA to form the complex that mediates dosage compensation on both X chromosomes in the monogametic sex, ultimately resulting in a two-fold reduction in transcription from these chromosomes. An example of this process is found in Caenorhabditis elegans." [GOC:jl, PMID:11102361, PMID:12672493]


id: GO:0042716
name: plasma membrane-derived chromatophore
namespace: cellular_component
def:
  "A pigment-bearing structure that is derived from the cytoplasmic membrane, sometimes consisting of simple invaginations and sometimes a complete vesicle. This component is found in certain photosynthetic bacteria and cyanobacteria." [GOC:jl, ISBN:0395825172, PMID:11867431]


id: GO:0042717
name: plasma membrane-derived chromatophore membrane
namespace: cellular_component
def:
  "The lipid bilayer associated with a plasma membrane-derived chromatophore; surrounds chromatophores that form complete vesicles." [GOC:jl, GOC:mah, ISBN:0395825172, PMID:11867431]


id: GO:0042718
name: yolk granule
namespace: cellular_component
def:
  "Discrete structures that partition the water-insoluble portion of the yolk of oocytes and ova, which may or may not be membrane enclosed." [GOC:jl, http://148.216.10.83/cellbio/eggs.htm, PMID:18046696]


id: GO:0042719
name: mitochondrial intermembrane space protein transporter complex
namespace: cellular_component
def:
  "Soluble complex of the mitochondrial intermembrane space composed of various combinations of small Tim proteins; acts as a protein transporter to guide proteins to the Tim22 complex for insertion into the mitochondrial inner membrane." [PMID:12581629]


id: GO:0042720
name: mitochondrial inner membrane peptidase complex
namespace: cellular_component
def:
  "Protease complex of the mitochondrial inner membrane, consisting of at least two subunits, involved in processing of both nuclear- and mitochondrially-encoded proteins targeted to the intermembrane space." [PMID:10821182, PMID:12191769]


id: GO:0042721
name: mitochondrial inner membrane protein insertion complex
namespace: cellular_component
def:
  "A multi-subunit complex embedded in the mitochondrial inner membrane that mediates insertion of carrier proteins into the inner membrane." [PMID:12191765]


id: GO:0042722
name: alpha-beta T cell activation by superantigen
namespace: biological_process
def:
  "The change in morphology and behavior of alpha-beta T cells resulting from exposure to a superantigen, a microbial antigen with an extremely potent activating effect on T cells that bear a specific variable region." [GOC:jl]


id: GO:0042723
name: thiamine-containing compound metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving thiamine (vitamin B1), and compounds derived from it." [CHEBI:26948, GOC:jl]


id: GO:0042724
name: thiamine-containing compound biosynthetic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of thiamine (vitamin B1), and related compounds." [CHEBI:26948, GOC:jl]


id: GO:0042725
name: thiamine-containing compound catabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the breakdown of thiamine (vitamin B1), and compounds derived from it." [CHEBI:26948, GOC:jl]


id: GO:0042726
name: flavin-containing compound metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving a flavin, any derivative of the dimethylisoalloxazine (7,8-dimethylbenzo[g]pteridine-2,4(3H,10H)-dione) skeleton, with a substituent on the 10 position." [CHEBI:30527, GOC:jl, GOC:mah]


id: GO:0042727
name: flavin-containing compound biosynthetic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of a flavin, any derivative of the dimethylisoalloxazine (7,8-dimethylbenzo[g]pteridine-2,4(3H,10H)-dione) skeleton, with a substituent on the 10 position." [CHEBI:30527, GOC:jl, GOC:mah]


id: GO:0042728
name: flavin-containing compound catabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the breakdown of a flavin, any derivative of the dimethylisoalloxazine (7,8-dimethylbenzo[g]pteridine-2,4(3H,10H)-dione) skeleton, with a substituent on the 10 position." [CHEBI:30527, GOC:jl, GOC:mah]


id: GO:0042729
name: DASH complex
namespace: cellular_component
def:
  "A large protein complex, containing around 8-10 subunits in yeast, including Duo1p, Dam1p, Dad1p and Ask1p. The complex forms part of the kinetochore, associates with microtubules when the kinetochore attaches to the spindle, and plays a role in spindle attachment, chromosome segregation and spindle stability." [GOC:jl, GOC:vw, http://www.wikigenes.org/e/gene/e/853090.html, PMID:11782438, PMID:11799062, PMID:15632076, PMID:15640796]


id: GO:0042730
name: fibrinolysis
namespace: biological_process
def:
  "A process that solubilizes fibrin in the bloodstream of a multicellular organism, chiefly by the proteolytic action of plasmin." [GOC:jl, PMID:15842654]


id: GO:0042731
name: PH domain binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with a PH domain (pleckstrin homology) of a protein, a domain of about 100 residues that occurs in a wide range of proteins involved in intracellular signaling or as constituents of the cytoskeleton." [GOC:jl, Pfam:PF00169]


id: GO:0042732
name: D-xylose metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving D-xylose, a naturally occurring plant polysaccharide." [ISBN:0198506732]


id: GO:0042733
name: embryonic digit morphogenesis
namespace: biological_process
def:
  "The process, occurring in the embryo, by which the anatomical structures of the digit are generated and organized. A digit is one of the terminal divisions of an appendage, such as a finger or toe." [GOC:bf, GOC:jl, UBERON:0002544]


id: GO:0042734
name: presynaptic membrane
namespace: cellular_component
def:
  "A specialized area of membrane of the axon terminal that faces the plasma membrane of the neuron or muscle fiber with which the axon terminal establishes a synaptic junction; many synaptic junctions exhibit structural presynaptic characteristics, such as conical, electron-dense internal protrusions, that distinguish it from the remainder of the axon plasma membrane." [GOC:jl, ISBN:0815316194]


id: GO:0042735
name: protein body
namespace: cellular_component
def:
  "A membrane-bounded plant organelle found in the developing endosperm, contains storage proteins." [GOC:jl, PMID:7704047]


id: GO:0042737
name: drug catabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the breakdown of a drug, a substance used in the diagnosis, treatment or prevention of a disease." [GOC:go_curators]


id: GO:0042738
name: exogenous drug catabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the breakdown of a drug that has originated externally to the cell or organism." [GOC:jl]


id: GO:0042739
name: endogenous drug catabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the breakdown of a drug that has originated internally within the cell or organism." [GOC:jl]


id: GO:0042740
name: exogenous antibiotic catabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the breakdown of an antibiotic that has originated externally to the cell or organism." [GOC:jl]


id: GO:0042741
name: endogenous antibiotic catabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the breakdown of an antibiotic that has originated internally within the cell or organism." [GOC:jl]


id: GO:0042742
name: defense response to bacterium
namespace: biological_process
def:
  "Reactions triggered in response to the presence of a bacterium that act to protect the cell or organism." [GOC:jl]


id: GO:0042743
name: hydrogen peroxide metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving hydrogen peroxide (H2O2), a potentially harmful byproduct of aerobic cellular respiration which can cause damage to DNA." [GOC:jl, http://biotech.icmb.utexas.edu/]


id: GO:0042744
name: hydrogen peroxide catabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the breakdown of hydrogen peroxide (H2O2)." [GOC:jl]


id: GO:0042745
name: circadian sleep/wake cycle
namespace: biological_process
def:
  "The cycle from wakefulness through an orderly succession of sleep states and stages that occurs on an approximately 24 hour rhythm." [GOC:jl, http://www.sleepquest.com]


id: GO:0042746
name: circadian sleep/wake cycle, wakefulness
namespace: biological_process
def:
  "The part of the circadian sleep/wake cycle where the organism is not asleep." [GOC:jl, PMID:12575468]


id: GO:0042747
name: circadian sleep/wake cycle, REM sleep
namespace: biological_process
def:
  "A stage in the circadian sleep cycle during which dreams occur and the body undergoes marked changes including rapid eye movement, loss of reflexes, and increased pulse rate and brain activity." [GOC:jl, ISBN:0395825172]


id: GO:0042748
name: circadian sleep/wake cycle, non-REM sleep
namespace: biological_process
def:
  "All sleep stages in the circadian sleep/wake cycle other than REM sleep. These stages are characterized by a slowing of brain waves and other physiological functions." [GOC:jl, http://www.sleepquest.com]


id: GO:0042749
name: regulation of circadian sleep/wake cycle
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of the circadian sleep/wake cycle." [GOC:jl]


id: GO:0042750
name: hibernation
namespace: biological_process
def:
  "Any process in which an organism enters and maintains a period of dormancy in which to pass the winter. It is characterized by narcosis and by sharp reduction in body temperature and metabolic activity and by a depression of vital signs." [GOC:jl, PMID:1945046]


id: GO:0042751
name: estivation
namespace: biological_process
def:
  "Any process in which an organism enters and maintains a period of dormancy, similar to hibernation, but that occurs during the summer. It insulates against heat to prevent the harmful effects of the season." [GOC:jl, PMID:12443930, Wikipedia:Estivation]


id: GO:0042752
name: regulation of circadian rhythm
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of a circadian rhythm. A circadian rhythm is a biological process in an organism that recurs with a regularity of approximately 24 hours." [GOC:dph, GOC:jl, GOC:tb]


id: GO:0042753
name: positive regulation of circadian rhythm
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of a circadian rhythm behavior." [GOC:go_curators]


id: GO:0042754
name: negative regulation of circadian rhythm
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of a circadian rhythm behavior." [GOC:go_curators]


id: GO:0042755
name: eating behavior
namespace: biological_process
def:
  "The specific behavior of an organism relating to the intake of food, any substance (usually solid) that can be metabolized by an organism to give energy and build tissue." [GOC:jl, GOC:pr, ISBN:01928006X]


id: GO:0042756
name: drinking behavior
namespace: biological_process
def:
  "The specific behavior of an organism relating to the intake of liquids, especially water." [GOC:curators, GOC:pr]


id: GO:0042757
name: giant axon
namespace: cellular_component
def:
  "Extremely large, unmyelinated axon found in invertebrates. Has high conduction speeds and is usually involved in panic or escape responses." [GOC:jl, PMID:9705477]


id: GO:0042758
name: long-chain fatty acid catabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the breakdown of long-chain fatty acids, a fatty acid with a chain length between C13 and C22." [CHEBI:15904, GOC:go_curators]


id: GO:0042759
name: long-chain fatty acid biosynthetic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of long-chain fatty acids, any fatty acid with a chain length between C13 and C22." [CHEBI:15904, GOC:go_curators]


id: GO:0042760
name: very long-chain fatty acid catabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the breakdown of a fatty acid which has a chain length greater than C22." [CHEBI:27283, GOC:go_curators]


id: GO:0042761
name: very long-chain fatty acid biosynthetic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of a fatty acid which has a chain length greater than C22." [CHEBI:27283, GOC:go_curators]


id: GO:0042762
name: regulation of sulfur metabolic process
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving sulfur, the nonmetallic element sulfur or compounds that contain sulfur." [GOC:go_curators]


id: GO:0042763
name: intracellular immature spore
namespace: cellular_component
def:
  "A cell or part of the cell that constitutes an early developmental stage of a spore, a small reproductive body that is highly resistant to desiccation and heat and is capable of growing into a new organism, produced especially by certain bacteria, fungi, algae, and nonflowering plants." [GOC:jl, ISBN:0395825172]


id: GO:0042764
name: ascospore-type prospore
namespace: cellular_component
def:
  "An immature spore undergoing development. The spore usually consists of nucleic acid, prospore membrane(s) that encase the nucleic acid, and ultimately a cell wall that covers the membrane(s). This type of spore is observed in ascospore-forming fungi." [GOC:go_curators]


id: GO:0042765
name: GPI-anchor transamidase complex
namespace: cellular_component
def:
  "An enzyme complex which in humans and yeast consists of at least five proteins; for example, the complex contains GAA1, GPI8, PIG-S, PIG-U, and PIG-T in human, and Gaa1p, Gab1p, Gpi8p, Gpi16p, and Gpi17p in yeast. Catalyzes the posttranslational attachment of the carboxyl-terminus of a precursor protein to a GPI-anchor." [GOC:jl, GOC:rb, PMID:12802054]


id: GO:0042769
name: DNA damage response, detection of DNA damage
namespace: biological_process
def:
  "The series of events required to receive a stimulus indicating DNA damage has occurred and convert it to a molecular signal." [GOC:go_curators]


id: GO:0042771
name: intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
namespace: biological_process
def:
  "A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage, and ends when the execution phase of apoptosis is triggered." [GOC:go_curators, GOC:mtg_apoptosis]


id: GO:0042772
name: DNA damage response, signal transduction resulting in transcription
namespace: biological_process
def:
  "A cascade of processes initiated in response to the detection of DNA damage, and resulting in the induction of transcription." [GOC:go_curators]


id: GO:0042773
name: ATP synthesis coupled electron transport
namespace: biological_process
def:
  "The transfer of electrons through a series of electron donors and acceptors, generating energy that is ultimately used for synthesis of ATP." [ISBN:0716731363]


id: GO:0042774
name: plasma membrane ATP synthesis coupled electron transport
namespace: biological_process
def:
  "The transfer of electrons through a series of electron donors and acceptors, generating energy that is ultimately used for synthesis of ATP in the plasma membrane." [GOC:mtg_sensu, ISBN:0716731363]


id: GO:0042775
name: mitochondrial ATP synthesis coupled electron transport
namespace: biological_process
def:
  "The transfer of electrons through a series of electron donors and acceptors, generating energy that is ultimately used for synthesis of ATP, as it occurs in the mitochondrial inner membrane or chloroplast thylakoid membrane." [GOC:mtg_sensu, ISBN:0716731363]


id: GO:0042776
name: mitochondrial ATP synthesis coupled proton transport
namespace: biological_process
def:
  "The transport of protons across a mitochondrial membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis." [GOC:mtg_sensu, ISBN:0716731363]


id: GO:0042777
name: plasma membrane ATP synthesis coupled proton transport
namespace: biological_process
def:
  "The transport of protons across the plasma membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis." [GOC:mtg_sensu, ISBN:0716731363]


id: GO:0042778
name: tRNA end turnover
namespace: biological_process
def:
  "The process in which the 3'-terminal CCA of a tRNA is removed and restored. This often happens to uncharged tRNA." [GOC:go_curators]


id: GO:0042779
name: tRNA 3'-trailer cleavage
namespace: biological_process
def:
  "Cleavage of the 3'-end of the pre-tRNA as part of the process of generating the mature 3'-end of the tRNA; may involve endonucleolytic or exonucleolytic cleavage, or both." [GOC:go_curators]


id: GO:0042780
name: tRNA 3'-end processing
namespace: biological_process
def:
  "The process in which the 3' end of a pre-tRNA molecule is converted to that of a mature tRNA." [GOC:go_curators]


id: GO:0042781
name: 3'-tRNA processing endoribonuclease activity
namespace: molecular_function
def:
  "Catalysis of the endonucleolytic cleavage of RNA, removing extra 3' nucleotides from tRNA precursor, generating 3' termini of tRNAs. A 3'-hydroxy group is left at the tRNA terminus and a 5'-phosphoryl group is left at the trailer molecule." [EC:3.1.26.11]


id: GO:0042782
name: passive evasion of host immune response
namespace: biological_process
def:
  "Any mechanism of immune avoidance that does not directly interfere with the host immune system; for example, some viruses enter a state of latency where their protein production is drastically downregulated, meaning that they are not detected by the host immune system. The host is defined as the larger of the organisms involved in a symbiotic interaction." [PMID:12439615]


id: GO:0042783
name: active evasion of host immune response
namespace: biological_process
def:
  "Any mechanism of immune avoidance that directly affects the host immune system, e.g. blocking any stage in host MHC class I and II presentation. The host is defined as the larger of the organisms involved in a symbiotic interaction." [PMID:12439615]


id: GO:0042784
name: active evasion of host immune response via regulation of host complement system
namespace: biological_process
def:
  "Any mechanism of active immune avoidance which works by regulating the host complement system, e.g. by possessing complement receptors which mediate attachment to, then infection of, host macrophages, which are eventually destroyed. The host is defined as the larger of the organisms involved in a symbiotic interaction." [http://www.brown.edu/Courses/Bio_160/Projects1999/ies/ces.html]


id: GO:0042785
name: active evasion of host immune response via regulation of host cytokine network
namespace: biological_process
def:
  "Any mechanism of active immune avoidance which works by regulating host cytokine networks, e.g. by secreting proteins that mimic cytokine receptors that act to sequester host cytokines and inhibit action. The host is defined as the larger of the organisms involved in a symbiotic interaction." [http://www.brown.edu/Courses/Bio_160/Projects1999/ies/cytok.html#Manipulation]


id: GO:0042786
name: active evasion of host immune response via regulation of host antigen processing and presentation
namespace: biological_process
def:
  "Any mechanism of active immune avoidance which works by regulating the host's antigen processing or presentation pathways, e.g. by blocking any stage in MHC class II presentation. The host is defined as the larger of the organisms involved in a symbiotic interaction." [PMID:12439615]


id: GO:0042787
name: protein ubiquitination involved in ubiquitin-dependent protein catabolic process
namespace: biological_process
def:
  "The process in which a ubiquitin group, or multiple groups, are covalently attached to the target protein, thereby initiating the degradation of that protein." [GOC:go_curators]


id: GO:0042789
name: mRNA transcription from RNA polymerase II promoter
namespace: biological_process
def:
  "The cellular synthesis of messenger RNA (mRNA) from a DNA template by RNA polymerase II, originating at an RNA polymerase II promoter." [GOC:jl, ISBN:0321000382]


id: GO:0042790
name: transcription of nuclear large rRNA transcript from RNA polymerase I promoter
namespace: biological_process
def:
  "The synthesis of the large ribosomal RNA (rRNA) transcript which encodes several rRNAs, e.g. in mammals 28S, 18S and 5.8S, from a nuclear DNA template transcribed by RNA polymerase I." [GOC:jl, GOC:txnOH, ISBN:0321000382]


id: GO:0042791
name: 5S class rRNA transcription from RNA polymerase III type 1 promoter
namespace: biological_process
def:
  "The synthesis of 5S ribosomal RNA (rRNA), or an equivalent rRNA, from a DNA template by RNA polymerase III (Pol III), originating at a type 1 RNA polymerase III promoter." [GOC:jl, GOC:txnOH, ISBN:0321000382, PMID:12381659]


id: GO:0042792
name: rRNA transcription from mitochondrial promoter
namespace: biological_process
def:
  "The synthesis of ribosomal RNA (rRNA) from a mitochondrial DNA template." [GOC:jl, ISBN:0321000382]


id: GO:0042793
name: transcription from plastid promoter
namespace: biological_process
def:
  "The synthesis of RNA from a plastid DNA template, usually by a specific plastid RNA polymerase." [GOC:jl, ISBN:0321000382]


id: GO:0042794
name: rRNA transcription from plastid promoter
namespace: biological_process
def:
  "The synthesis of ribosomal RNA (rRNA) from a plastid DNA template, usually by a specific plastid RNA polymerase." [GOC:jl, ISBN:0321000382]


id: GO:0042795
name: snRNA transcription from RNA polymerase II promoter
namespace: biological_process
def:
  "The synthesis of small nuclear RNA (snRNA) from a DNA template by RNA Polymerase II (Pol II), originating at a Pol II promoter." [GOC:jl, ISBN:0321000382]


id: GO:0042796
name: snRNA transcription from RNA polymerase III promoter
namespace: biological_process
def:
  "The synthesis of small nuclear RNA (snRNA) from a DNA template by RNA Polymerase III (Pol III), originating at a Pol III promoter." [GOC:jl, ISBN:0321000382]


id: GO:0042797
name: tRNA transcription from RNA polymerase III promoter
namespace: biological_process
def:
  "The synthesis of transfer RNA (tRNA) from a DNA template by RNA Polymerase III (Pol III), originating at a Pol III promoter." [GOC:jl, ISBN:0321000382]


id: GO:0042798
name: obsolete protein neddylation during NEDD8 class-dependent protein catabolic process
namespace: biological_process
def:
  "OBSOLETE. Covalent attachment of the ubiquitin-like protein NEDD8 (or equivalent protein) to another protein, as a part of NEDD8-dependant protein catabolism." [GOC:jl]


id: GO:0042799
name: histone methyltransferase activity (H4-K20 specific)
namespace: molecular_function
def:
  "Catalysis of the reaction: S-adenosyl-L-methionine + histone H4 L-lysine (position 20) = S-adenosyl-L-homocysteine + histone H4 N6-methyl-L-lysine (position 20). This reaction is the addition of a methyl group onto lysine at position 20 of the histone H4 protein." [PMID:12086618]


id: GO:0042800
name: histone methyltransferase activity (H3-K4 specific)
namespace: molecular_function
def:
  "Catalysis of the reaction: S-adenosyl-L-methionine + histone H3 L-lysine (position 4) = S-adenosyl-L-homocysteine + histone H3 N6-methyl-L-lysine (position 4). This reaction is the addition of a methyl group onto lysine at position 4 of the histone H3 protein." [PMID:12086618]


id: GO:0042801
name: polo kinase kinase activity
namespace: molecular_function
def:
  "Catalysis of the addition of a phosphate group onto a serine or threonine residue in any member of the polo kinase class of proteins." [GOC:ma]


id: GO:0042803
name: protein homodimerization activity
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with an identical protein to form a homodimer." [GOC:jl]


id: GO:0042805
name: actinin binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with actinin, any member of a family of proteins that crosslink F-actin." [GOC:jl, ISBN:0198506732]


id: GO:0042806
name: fucose binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with fucose, the pentose 6-deoxygalactose." [CHEBI:33984, ISBN:0582227089]


id: GO:0042807
name: central vacuole
namespace: cellular_component
def:
  "A membrane-enclosed sac that takes up most of the volume of a mature plant cell. Functions include storage, separation of toxic byproducts, and cell growth determination." [ISBN:9780815341116, Wikipedia:Vacuole]


id: GO:0042808
name: obsolete neuronal Cdc2-like kinase binding
namespace: molecular_function
def:
  "OBSOLETE. Interacting selectively and non-covalently with neuronal Cdc2-like kinase, an enzyme involved in the regulation of neuronal differentiation and neuro-cytoskeleton dynamics." [GOC:jl, PMID:10721722]


id: GO:0042809
name: vitamin D receptor binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with the vitamin D receptor, a nuclear receptor that mediates the action of vitamin D by binding DNA and controlling the transcription of hormone-sensitive genes." [GOC:jl, PMID:12637589]


id: GO:0042810
name: pheromone metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving pheromones, a substance that is secreted and released by an organism and detected by a second organism of the same or a closely related species, in which it causes a specific reaction, such as a definite behavioral reaction or a developmental process." [ISBN:0198506732]


id: GO:0042811
name: pheromone biosynthetic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of pheromones, a substance that is secreted and released by an organism and detected by a second organism of the same or a closely related species, in which it causes a specific reaction, such as a definite behavioral reaction or a developmental process." [ISBN:0198506732]


id: GO:0042812
name: pheromone catabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the breakdown of pheromones, a substance that is secreted and released by an organism and detected by a second organism of the same or a closely related species, in which it causes a specific reaction, such as a definite behavioral reaction or a developmental process." [ISBN:0198506732]


id: GO:0042813
name: Wnt-activated receptor activity
namespace: molecular_function
def:
  "Combining with a Wnt protein and transmitting the signal across the plasma membrane to initiate a change in cell activity." [GOC:go_curators]


id: GO:0042815
name: bipolar cell growth
namespace: biological_process
def:
  "The process in which a cell irreversibly increases in size along one axis through simultaneous polarized growth from opposite ends of a cell, resulting in morphogenesis of the cell." [GOC:vw]


id: GO:0042816
name: vitamin B6 metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving any of the vitamin B6 compounds: pyridoxal, pyridoxamine and pyridoxine and the active form, pyridoxal phosphate." [GOC:jl, http://www.indstate.edu/thcme/mwking/vitamins.html]


id: GO:0042817
name: pyridoxal metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving 3-hydroxy-5-(hydroxymethyl)-2-methyl-4-pyridinecarboxaldehyde, one of the vitamin B6 compounds. Pyridoxal, pyridoxamine and pyridoxine are collectively known as vitamin B6, and are efficiently converted to the biologically active form of vitamin B6, pyridoxal phosphate." [GOC:jl, http://www.mblab.gla.ac.uk/]


id: GO:0042818
name: pyridoxamine metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving 4-(aminomethyl)-5-(hydroxymethyl)-2-methylpyridin-3-ol, one of the vitamin B6 compounds. Pyridoxal, pyridoxamine and pyridoxine are collectively known as vitamin B6, and are efficiently converted to the biologically active form of vitamin B6, pyridoxal phosphate." [CHEBI:16410, GOC:jl]


id: GO:0042819
name: vitamin B6 biosynthetic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of any of the vitamin B6 compounds; pyridoxal, pyridoxamine and pyridoxine and the active form, pyridoxal phosphate." [GOC:jl, http://www.indstate.edu/thcme/mwking/vitamins.html]


id: GO:0042820
name: vitamin B6 catabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the breakdown of any of the vitamin B6 compounds; pyridoxal, pyridoxamine and pyridoxine and the active form, pyridoxal phosphate." [GOC:jl, http://www.indstate.edu/thcme/mwking/vitamins.html]


id: GO:0042821
name: pyridoxal biosynthetic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of 3-hydroxy-5-(hydroxymethyl)-2-methyl-4-pyridinecarboxaldehyde, one of the vitamin B6 compounds." [GOC:jl, http://www.mblab.gla.ac.uk/]


id: GO:0042822
name: pyridoxal phosphate metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving pyridoxal phosphate, pyridoxal phosphorylated at the hydroxymethyl group of C-5, the active form of vitamin B6." [GOC:jl, http://www.mercksource.com/]


id: GO:0042823
name: pyridoxal phosphate biosynthetic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of pyridoxal phosphate, pyridoxal phosphorylated at the hydroxymethyl group of C-5, the active form of vitamin B6." [GOC:jl, http://www.mercksource.com/]


id: GO:0042824
name: MHC class I peptide loading complex
namespace: cellular_component
def:
  "A large, multisubunit complex which consists of the MHC class I-beta 2 microglobulin dimer, the transporter associated with antigen presentation (TAP), tapasin (an MHC-encoded membrane protein), the chaperone calreticulin and the thiol oxidoreductase ERp57. Functions in the assembly of peptides with newly synthesized MHC class I molecules." [GOC:jl, PMID:10631934]


id: GO:0042825
name: TAP complex
namespace: cellular_component
def:
  "A heterodimer composed of the subunits TAP1 and TAP2 (transporter associated with antigen presentation). Functions in the transport of antigenic peptides from the cytosol to the lumen of the endoplasmic reticulum." [GOC:jl, PMID:10618487, PMID:10631934]


id: GO:0042827
name: platelet dense granule
namespace: cellular_component
def:
  "Electron-dense granule occurring in blood platelets that stores and secretes adenosine nucleotides and serotonin. They contain a highly condensed core consisting of serotonin, histamine, calcium, magnesium, ATP, ADP, pyrophosphate and membrane lysosomal proteins." [GOC:jl, http://www.mercksource.com/, PMID:10403682, PMID:11487378]


id: GO:0042832
name: defense response to protozoan
namespace: biological_process
def:
  "Reactions triggered in response to the presence of a protozoan that act to protect the cell or organism." [GOC:jl]


id: GO:0042834
name: peptidoglycan binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently, in a non-covalent manner, with peptidoglycan, any of a class of glycoconjugates found in bacterial cell walls." [GOC:go_curators, PMID:14698226]


id: GO:0042835
name: BRE binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with the RNA element BRE (Bruno response element)." [PMID:10893231]


id: GO:0042836
name: D-glucarate metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving D-glucarate, the D-enantiomer of glucarate. D-glucarate is derived from either D-glucose or L-gulose." [GOC:jsg, GOC:mah, ISBN:0198506732]


id: GO:0042837
name: D-glucarate biosynthetic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of D-glucarate, the D-enantiomer of glucarate." [GOC:jsg, GOC:mah, ISBN:0198506732]


id: GO:0042838
name: D-glucarate catabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the breakdown of D-glucarate, the D-enantiomer of glucarate." [GOC:jsg, GOC:mah, ISBN:0198506732]


id: GO:0042839
name: D-glucuronate metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving D-glucuronate, the D-enantiomer of glucuronate." [GOC:jl, GOC:jsg, GOC:mah]


id: GO:0042840
name: D-glucuronate catabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the breakdown of D-glucuronate, the D-enantiomer of glucuronate." [GOC:jl, GOC:jsg, GOC:mah]


id: GO:0042841
name: D-glucuronate biosynthetic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of D-glucuronate, the D-enantiomer of glucuronate." [GOC:jl, GOC:jsg, GOC:mah]


id: GO:0042842
name: D-xylose biosynthetic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of D-xylose, a naturally occurring plant polysaccharide." [ISBN:0198506732]


id: GO:0042843
name: D-xylose catabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the breakdown of D-xylose, a naturally occurring plant polysaccharide." [ISBN:0198506732]


id: GO:0042844
name: glycol metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving glycol, a diol in which the two hydroxy groups are on different carbon atoms, usually but not necessarily adjacent." [CHEBI:13643, http://www.cogsci.princeton.edu/~wn/]


id: GO:0042845
name: glycol biosynthetic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of glycol, a diol in which the two hydroxy groups are on different carbon atoms, usually but not necessarily adjacent." [CHEBI:13643, http://www.cogsci.princeton.edu/~wn/]


id: GO:0042846
name: glycol catabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the breakdown of glycol, a diol in which the two hydroxy groups are on different carbon atoms, usually but not necessarily adjacent." [CHEBI:13643, http://www.cogsci.princeton.edu/~wn/]


id: GO:0042847
name: sorbose biosynthetic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of sorbose, the ketohexose xylo-2-hexulose. Sorbose is produced commercially by fermentation and is used as an intermediate in the manufacture of ascorbic acid." [ISBN:0198506732]


id: GO:0042848
name: sorbose catabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the breakdown of sorbose, the ketohexose xylo-2-hexulose. Sorbose is produced commercially by fermentation and is used as an intermediate in the manufacture of ascorbic acid." [ISBN:0198506732]


id: GO:0042849
name: L-sorbose biosynthetic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of L-sorbose, the L-enantiomer of the ketohexose xylo-2-hexulose. L-sorbose is formed by bacterial oxidation of sorbitol." [CHEBI:17266, GOC:jsg, GOC:mah, ISBN:0198506732]


id: GO:0042850
name: L-sorbose catabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the breakdown of L-sorbose, the L-enantiomer of the ketohexose xylo-2-hexulose." [CHEBI:17266, GOC:jsg, GOC:mah, ISBN:0198506732]


id: GO:0042851
name: L-alanine metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving L-alanine, the L-enantiomer of 2-aminopropanoic acid, i.e. (2S)-2-aminopropanoic acid." [CHEBI:16977, GOC:jl, GOC:jsg, GOC:mah]


id: GO:0042852
name: L-alanine biosynthetic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of L-alanine, the L-enantiomer of 2-aminopropanoic acid, i.e. (2S)-2-aminopropanoic acid." [CHEBI:16977, GOC:jl, GOC:jsg, GOC:mah]


id: GO:0042853
name: L-alanine catabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the breakdown of L-alanine, the L-enantiomer of 2-aminopropanoic acid, i.e. (2S)-2-aminopropanoic acid." [CHEBI:16977, GOC:jl, GOC:jsg, GOC:mah]


id: GO:0042854
name: eugenol metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving eugenol, a colorless, aromatic, liquid hydrocarbon (C10H12O2) found in clove oil." [CHEBI:4917, GOC:jl]


id: GO:0042855
name: eugenol biosynthetic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of eugenol, a colorless, aromatic, liquid hydrocarbon (C10H12O2) found in clove oil." [CHEBI:4917, GOC:jl]


id: GO:0042856
name: eugenol catabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the breakdown of eugenol, a colorless, aromatic, liquid hydrocarbon (C10H12O2) found in clove oil." [CHEBI:4917, GOC:jl]


id: GO:0042857
name: chrysobactin metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving the siderophore chrysobactin (alpha-N-(2,3-dihydroxybenzoyl)-D-lysyl-L-serine)." [GOC:jl, PMID:8837459]


id: GO:0042858
name: chrysobactin biosynthetic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of the siderophore chrysobactin (alpha-N-(2,3-dihydroxybenzoyl)-D-lysyl-L-serine)." [GOC:jl, PMID:8837459]


id: GO:0042859
name: chrysobactin catabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the breakdown of the siderophore chrysobactin (alpha-N-(2,3-dihydroxybenzoyl)-D-lysyl-L-serine)." [GOC:jl, PMID:8837459]


id: GO:0042860
name: achromobactin metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving achromobactin, a citrate siderophore." [GOC:jl, PMID:10928541]


id: GO:0042861
name: achromobactin biosynthetic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of achromobactin, a citrate siderophore." [GOC:jl, PMID:10928541]


id: GO:0042862
name: achromobactin catabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the breakdown of achromobactin, a citrate siderophore." [GOC:jl, PMID:10928541]


id: GO:0042863
name: pyochelin metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving the siderochrome pyochelin (2-(2-o-hydroxyphenyl-2-thiazolin-4-yl)-3-methylthiazolidine-4-carboxylic acid)." [GOC:jl, PMID:6794030]


id: GO:0042864
name: pyochelin biosynthetic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of the siderochrome pyochelin (2-(2-o-hydroxyphenyl-2-thiazolin-4-yl)-3-methylthiazolidine-4-carboxylic acid)." [GOC:jl, PMID:6794030]


id: GO:0042865
name: pyochelin catabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the breakdown of the siderochrome pyochelin (2-(2-o-hydroxyphenyl-2-thiazolin-4-yl)-3-methylthiazolidine-4-carboxylic acid)." [GOC:jl, PMID:6794030]


id: GO:0042866
name: pyruvate biosynthetic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of pyruvate, 2-oxopropanoate." [GOC:go_curators]


id: GO:0042867
name: pyruvate catabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the breakdown of pyruvate, 2-oxopropanoate." [GOC:go_curators]


id: GO:0042868
name: antisense RNA metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving antisense RNA, an RNA molecule complementary in sequence to another RNA or DNA molecule, which, by binding the latter, acts to inhibit its function and/or completion of synthesis." [GOC:jl]


id: GO:0042869
name: aldarate transport
namespace: biological_process
def:
  "The directed movement of aldarate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:go_curators]


id: GO:0042870
name: D-glucarate transport
namespace: biological_process
def:
  "The directed movement of D-glucarate, the D-enantiomer of glucarate, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl, GOC:jsg, GOC:mah, ISBN:0198506732]


id: GO:0042873
name: aldonate transport
namespace: biological_process
def:
  "The directed movement of aldonate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl]


id: GO:0042874
name: D-glucuronate transport
namespace: biological_process
def:
  "The directed movement of D-glucuronate, the D-enantiomer of glucuronate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl, GOC:jsg, GOC:mah]


id: GO:0042875
name: D-galactonate transport
namespace: biological_process
def:
  "The directed movement of D-galactonate, the D-enantiomer of galactonate, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl, GOC:jsg, GOC:mah]


id: GO:0042876
name: aldarate transmembrane transporter activity
namespace: molecular_function
def:
  "Enables the transfer of aldarate from one side of the membrane to the other." [GOC:go_curators, PMID:15034926]


id: GO:0042878
name: D-glucarate transmembrane transporter activity
namespace: molecular_function
def:
  "Enables the transfer of D-glucarate, the D-enantiomer of glucarate, from one side of the membrane to the other." [GOC:jl, GOC:jsg, GOC:mah, GOC:mtg_transport, ISBN:0198506732, ISBN:0815340729]


id: GO:0042879
name: aldonate transmembrane transporter activity
namespace: molecular_function
def:
  "Enables the transfer of aldonate from one side of the membrane to the other." [GOC:jl, GOC:mtg_transport, ISBN:0815340729]


id: GO:0042880
name: D-glucuronate transmembrane transporter activity
namespace: molecular_function
def:
  "Enables the transfer of D-glucuronate, the D-enantiomer of glucuronate, from one side of the membrane to the other." [GOC:jl, GOC:jsg, GOC:mah, GOC:mtg_transport, ISBN:0198506732, ISBN:0815340729]


id: GO:0042881
name: D-galactonate transmembrane transporter activity
namespace: molecular_function
def:
  "Enables the transfer of D-galactonate, the D-enantiomer of galactonate, from one side of the membrane to the other." [GOC:jl, GOC:jsg, GOC:mah, GOC:mtg_transport, ISBN:0198506732, ISBN:0815340729]


id: GO:0042882
name: L-arabinose transport
namespace: biological_process
def:
  "The directed movement of L-arabinose, the L-enantiomer of arabinose, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl, GOC:jsg, GOC:mah, ISBN:0198506732]


id: GO:0042883
name: cysteine transport
namespace: biological_process
def:
  "The directed movement of cysteine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl, ISBN:0198506732]


id: GO:0042884
name: microcin transport
namespace: biological_process
def:
  "The directed movement of microcin, a class of glycine-rich, bactericidal peptides (antibiotics) produced by some enteric bacteria, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl, ISBN:0198506732, PMID:11292337]


id: GO:0042885
name: microcin B17 transport
namespace: biological_process
def:
  "The directed movement of microcin B17, a bactericidal peptide (antibiotic) produced by some enteric bacteria, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl, PMID:11292337]


id: GO:0042886
name: amide transport
namespace: biological_process
def:
  "The directed movement of an amide, any compound containing one, two, or three acyl groups attached to a nitrogen atom, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl, ISBN:0198506732]


id: GO:0042887
name: amide transmembrane transporter activity
namespace: molecular_function
def:
  "Enables directed movement of an amide, any compound containing one, two, or three acyl groups attached to a nitrogen atom, from one side of the membrane to the other." [GOC:jl, ISBN:0198506732]


id: GO:0042888
name: molybdenum ion transmembrane transporter activity
namespace: molecular_function
def:
  "Enables the transfer of molybdenum (Mo) ions from one side of a membrane to the other." [GOC:jl, ISBN:0198506732]


id: GO:0042889
name: 3-phenylpropionic acid transport
namespace: biological_process
def:
  "The directed movement of 3-phenylpropionic acid into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl]


id: GO:0042890
name: 3-phenylpropionic acid transmembrane transporter activity
namespace: molecular_function
def:
  "Enables the transfer of 3-phenylpropionic acid from one side of the membrane to the other." [GOC:jl]


id: GO:0042891
name: antibiotic transport
namespace: biological_process
def:
  "The directed movement of an antibiotic, a substance produced by or derived from certain fungi, bacteria, and other organisms, that can destroy or inhibit the growth of other microorganisms, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl]


id: GO:0042892
name: chloramphenicol transport
namespace: biological_process
def:
  "The directed movement of chloramphenicol, a broad-spectrum antibiotic that inhibits bacterial protein synthesis, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [CHEBI:17698, GOC:jl]


id: GO:0042893
name: polymyxin transport
namespace: biological_process
def:
  "The directed movement of polymyxin, any of a group of related antibiotics produced by Bacillus polymyxa and active against most Gram-negative bacteria, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl, ISBN:0198506732]


id: GO:0042894
name: fosmidomycin transport
namespace: biological_process
def:
  "The directed movement of fosmidomycin, a phosphonic acid derivative with potent activity against Gram-negative organisms, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl, PMID:12543685]


id: GO:0042895
name: antibiotic transporter activity
namespace: molecular_function
def:
  "Enables the directed movement of an antibiotic, a substance produced by or derived from certain fungi, bacteria, and other organisms, that can destroy or inhibit the growth of other microorganisms, into, out of or within a cell, or between cells." [GOC:jl]


id: GO:0042896
name: chloramphenicol transporter activity
namespace: molecular_function
def:
  "Enables the directed movement of chloramphenicol, a broad-spectrum antibiotic that inhibits bacterial protein synthesis, into, out of or within a cell, or between cells." [CHEBI:17698, GOC:jl]


id: GO:0042897
name: polymyxin transporter activity
namespace: molecular_function
def:
  "Enables the directed movement of polymyxin, any of a group of related antibiotics produced by Bacillus polymyxa and active against most Gram-negative bacteria, into, out of or within a cell, or between cells." [GOC:jl, ISBN:0198506732]


id: GO:0042898
name: fosmidomycin transporter activity
namespace: molecular_function
def:
  "Enables the directed movement of fosmidomycin, a phosphonic acid derivative with potent activity against Gram-negative organisms, into, out of or within a cell, or between cells." [GOC:jl, PMID:12543685]


id: GO:0042899
name: arabinan transport
namespace: biological_process
def:
  "The directed movement of arabinan, a polysaccharide composed of arabinose residues, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl]


id: GO:0042900
name: arabinose transmembrane transporter activity
namespace: molecular_function
def:
  "Enables the transfer of arabinose, a pentose monosaccharide that occurs in both D and L configurations, and as a polymer, from one side of the membrane to the other." [CHEBI:22599, GOC:jl, GOC:mtg_transport, ISBN:0815340729]


id: GO:0042901
name: arabinan transmembrane transporter activity
namespace: molecular_function
def:
  "Enables the transfer of an arabinan, a polysaccharide composed of arabinose residues, from one side of the membrane to the other." [GOC:jl, GOC:mtg_transport, ISBN:0815340729]


id: GO:0042902
name: peptidoglycan-protein cross-linking via L-threonyl-pentaglycyl-murein
namespace: biological_process
def:
  "The process of linking a protein to peptidoglycan via a carboxy terminal threonine carboxyl group through a pentaglycyl peptide to the lysine or diaminopimelic acid of the peptidoglycan." [RESID:AA0345]


id: GO:0042903
name: tubulin deacetylase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: N-acetyl(alpha-tubulin) + H2O = alpha-tubulin + acetate." [PMID:12024216, PMID:12486003]


id: GO:0042904
name: 9-cis-retinoic acid biosynthetic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of 9-cis-retinoic acid, a metabolically active vitamin A derivative." [GOC:jl, PMID:11279029]


id: GO:0042905
name: 9-cis-retinoic acid metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving 9-cis-retinoic acid, a metabolically active vitamin A derivative." [GOC:jl, PMID:11279029]


id: GO:0042906
name: xanthine transport
namespace: biological_process
def:
  "The directed movement of xanthine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Xanthine (2,6-dihydroxypurine) is a purine formed in the metabolic breakdown of guanine, but is not present in nucleic acids." [GOC:jl]


id: GO:0042907
name: xanthine transmembrane transporter activity
namespace: molecular_function
def:
  "Enables the transfer of xanthine from one side of a membrane to the other. Xanthine (2,6-dihydroxypurine) is a purine formed in the metabolic breakdown of guanine, but is not present in nucleic acids." [GOC:jl]


id: GO:0042908
name: xenobiotic transport
namespace: biological_process
def:
  "The directed movement of a xenobiotic, a compound foreign to living organisms, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:go_curators]


id: GO:0042909
name: acridine transport
namespace: biological_process
def:
  "The directed movement of acridine (10-azaanthracene), a heterocyclic ring compound found in crude coal-tar anthracene, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [CHEBI:36420, GOC:jl, Wikipedia:Acridine]


id: GO:0042910
name: xenobiotic transporter activity
namespace: molecular_function
def:
  "Enables the directed movement of a xenobiotic, a compound foreign to living organisms, into, out of or within a cell, or between cells." [GOC:go_curators]


id: GO:0042911
name: acridine transporter activity
namespace: molecular_function
def:
  "Enables the directed movement of acridine (10-azaanthracene), a heterocyclic ring compound found in crude coal-tar anthracene, into, out of or within a cell, or between cells." [CHEBI:36420, GOC:jl]


id: GO:0042912
name: colicin transmembrane transporter activity
namespace: molecular_function
def:
  "Enables the transfer of a colicin from one side of a membrane to the other. Colicins are a group of antibiotics produced by E. coli and related species that are encoded by a group of naturally occurring plasmids, e.g. Col E1." [GOC:jl, GOC:mtg_transport, ISBN:0815340729, PMID:17347522]


id: GO:0042913
name: group A colicin transmembrane transporter activity
namespace: molecular_function
def:
  "Enables the transfer of group A colicins (colicins E1, E2, E3, A, K, and N) from one side of a membrane to the other." [GOC:jl, GOC:mtg_transport, ISBN:0815340729, PMID:9171417]


id: GO:0042914
name: colicin transport
namespace: biological_process
def:
  "The directed movement of a colicin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Colicins are a group of antibiotics produced by E. coli and related species that are encoded by a group of naturally occurring plasmids, e.g. Col E1." [GOC:jl, PMID:17347522]


id: GO:0042915
name: group A colicin transport
namespace: biological_process
def:
  "The directed movement of group A colicins (colicins E1, E2, E3, A, K, and N) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl, PMID:9171417]


id: GO:0042916
name: alkylphosphonate transport
namespace: biological_process
def:
  "The directed movement of an alkylphosphonate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:go_curators]


id: GO:0042917
name: alkylphosphonate transmembrane transporter activity
namespace: molecular_function
def:
  "Enables the transfer of an alkylphosphonate from one side of a membrane to the other." [GOC:go_curators]


id: GO:0042918
name: alkanesulfonate transport
namespace: biological_process
def:
  "The directed movement of an alkanesulfonate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Alkanesulfonates are organic esters or salts of sulfonic acid containing an aliphatic hydrocarbon radical." [CHEBI:22318, GOC:jl]


id: GO:0042919
name: benzoate transport
namespace: biological_process
def:
  "The directed movement of benzoate, the anion of benzoic acid (benzenecarboxylic acid) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl, ISBN:0721662544]


id: GO:0042920
name: 3-hydroxyphenylpropionic acid transport
namespace: biological_process
def:
  "The directed movement of 3-hydroxyphenylpropionic acid into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:go_curators]


id: GO:0042921
name: glucocorticoid receptor signaling pathway
namespace: biological_process
def:
  "Any series of molecular signals generated as a consequence of a glucocorticoid binding to its receptor." [GOC:mah]


id: GO:0042922
name: neuromedin U receptor binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with one or more specific sites on a neuromedin U receptor." [GOC:jl, PMID:10899166]


id: GO:0042923
name: neuropeptide binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently and stoichiometrically with neuropeptides, peptides with direct synaptic effects (peptide neurotransmitters) or indirect modulatory effects on the nervous system (peptide neuromodulators)." [http://www.wormbook.org/chapters/www_neuropeptides/neuropeptides.html]


id: GO:0042924
name: neuromedin U binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently and stoichiometrically with neuromedin U, a hypothalamic peptide involved in energy homeostasis and stress responses." [GOC:jl, PMID:12584108]


id: GO:0042925
name: benzoate transporter activity
namespace: molecular_function
def:
  "Enables the directed movement of benzoate, the anion of benzoic acid (benzenecarboxylic acid) into, out of or within a cell, or between cells." [GOC:jl, ISBN:0721662544]


id: GO:0042926
name: 3-hydroxyphenylpropionic acid transporter activity
namespace: molecular_function
def:
  "Enables the directed movement of 3-hydroxyphenylpropionic acid into, out of or within a cell, or between cells." [GOC:jl]


id: GO:0042927
name: siderophore transporter activity
namespace: molecular_function
def:
  "Enables the directed movement of siderophores, low molecular weight Fe(III)-chelating substances, into, out of or within a cell, or between cells." [GOC:go_curators]


id: GO:0042928
name: ferrichrome transport
namespace: biological_process
def:
  "The directed movement of a ferrichrome into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Ferrichromes are any of a group of growth-promoting Fe(III) chelates formed by various genera of microfungi. They are homodetic cyclic hexapeptides made up of a tripeptide of glycine (or other small neutral amino acids) and a tripeptide of an N'acyl-N4-hydroxy-L-ornithine." [GOC:jl, ISBN:0198506732]


id: GO:0042929
name: ferrichrome transporter activity
namespace: molecular_function
def:
  "Enables the directed movement of a ferrichrome into, out of or within a cell, or between cells. Ferrichromes are any of a group of growth-promoting Fe(III) chelates formed by various genera of microfungi. They are homodetic cyclic hexapeptides made up of a tripeptide of glycine (or other small neutral amino acids) and a tripeptide of an N'acyl-N4-hydroxy-L-ornithine." [GOC:jl, ISBN:0198506732]


id: GO:0042930
name: enterobactin transport
namespace: biological_process
def:
  "The directed movement of the siderochrome enterobactin, a cyclic trimer of 2, 3 dihydroxybenzoylserine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [CHEBI:28855, GOC:jl]


id: GO:0042931
name: enterobactin transporter activity
namespace: molecular_function
def:
  "Enables the directed movement of the siderochrome enterochelin, a cyclic trimer of 2, 3 dihydroxybenzoylserine into, out of or within a cell, or between cells." [CHEBI:28855, GOC:jl]


id: GO:0042932
name: chrysobactin transport
namespace: biological_process
def:
  "The directed movement of the siderophore chrysobactin (alpha-N-(2,3-dihydroxybenzoyl)-D-lysyl-L-serine) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl, PMID:8837459]


id: GO:0042933
name: chrysobactin transporter activity
namespace: molecular_function
def:
  "Enables the directed movement of the siderophore chrysobactin (alpha-N-(2,3-dihydroxybenzoyl)-D-lysyl-L-serine) into, out of or within a cell, or between cells." [GOC:jl, PMID:8837459]


id: GO:0042934
name: achromobactin transporter activity
namespace: molecular_function
def:
  "Enables the directed movement of achromobactin, a citrate siderophore, into, out of or within a cell, or between cells." [GOC:jl]


id: GO:0042935
name: achromobactin transport
namespace: biological_process
def:
  "The directed movement of achromobactin, a citrate siderophore, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl, PMID:10928541]


id: GO:0042936
name: dipeptide transporter activity
namespace: molecular_function
def:
  "Enables the directed movement of a dipeptide, a combination of two amino acids by means of a peptide (-CO-NH-) link, into, out of or within a cell, or between cells." [CHEBI:46761, GOC:jl]


id: GO:0042937
name: tripeptide transporter activity
namespace: molecular_function
def:
  "Enables the directed movement of a tripeptide, a compound containing three amino acids linked together by peptide bonds, into, out of or within a cell, or between cells." [CHEBI:47923, GOC:jl]


id: GO:0042938
name: dipeptide transport
namespace: biological_process
def:
  "The directed movement of a dipeptide, a combination of two amino acids by means of a peptide (-CO-NH-) link, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [CHEBI:46761, GOC:jl]


id: GO:0042939
name: tripeptide transport
namespace: biological_process
def:
  "The directed movement of a tripeptide, a compound containing three amino acids linked together by peptide bonds, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [CHEBI:47923, GOC:jl]


id: GO:0042940
name: D-amino acid transport
namespace: biological_process
def:
  "The directed movement of the D-enantiomer of an amino acid into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl, GOC:jsg, GOC:mah]


id: GO:0042941
name: D-alanine transport
namespace: biological_process
def:
  "The directed movement of D-alanine, the D-enantiomer of 2-aminopropanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [CHEBI:15570, GOC:jl, GOC:jsg, GOC:mah]


id: GO:0042942
name: D-serine transport
namespace: biological_process
def:
  "The directed movement of D-serine, the D-enantiomer of 2-amino-3-hydroxypropanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl, GOC:jsg, GOC:mah]


id: GO:0042943
name: D-amino acid transmembrane transporter activity
namespace: molecular_function
def:
  "Enables the transfer of D-amino acids from one side of a membrane to the other. D-amino acids are the D-enantiomers of amino acids." [GOC:jl, GOC:jsg, GOC:mah, GOC:mtg_transport, ISBN:0815340729]


id: GO:0042944
name: D-alanine transmembrane transporter activity
namespace: molecular_function
def:
  "Enables the transfer of D-alanine from one side of a membrane to the other. D-alanine is the D-enantiomer of 2-aminopropanoic acid." [CHEBI:15570, GOC:jl, GOC:mtg_transport, ISBN:0815340729]


id: GO:0042945
name: D-serine transmembrane transporter activity
namespace: molecular_function
def:
  "Enables the transfer of D-serine from one side of a membrane to the other. D-serine is the D-enantiomer of 2-amino-3-hydroxypropanoic acid." [GOC:jl, GOC:jsg, GOC:mah, GOC:mtg_transport, ISBN:0815340729]


id: GO:0042946
name: glucoside transport
namespace: biological_process
def:
  "The directed movement of glucosides into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Glucosides are glycosides in which the sugar group is a glucose residue." [GOC:jl, ISBN:0198506732]


id: GO:0042947
name: glucoside transmembrane transporter activity
namespace: molecular_function
def:
  "Enables the transfer of glucosides from one side of the membrane to the other. Glucosides are glycosides in which the sugar group is a glucose residue." [GOC:jl, GOC:mtg_transport, ISBN:0815340729]


id: GO:0042948
name: salicin transport
namespace: biological_process
def:
  "The directed movement of salicin (saligenin-beta-D-glucopyranoside), a glucoside of o-hydroxybenzylalcohol, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [CHEBI:17814, GOC:jl]


id: GO:0042949
name: arbutin transport
namespace: biological_process
def:
  "The directed movement of arbutin, a glycoside found in the bearberry and related plants which has been used to treat urinary-tract diseases, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl, http://biotech.icmb.utexas.edu/]


id: GO:0042950
name: salicin transmembrane transporter activity
namespace: molecular_function
def:
  "Enables the transfer of salicin (saligenin-beta-D-glucopyranoside), a glucoside of o-hydroxybenzylalcohol, from one side of the membrane to the other." [CHEBI:17814, GOC:jl, GOC:mtg_transport, ISBN:0815340729]


id: GO:0042951
name: arbutin transmembrane transporter activity
namespace: molecular_function
def:
  "Enables the transfer of arbutin, a glycoside found in the bearberry and related plants which has been used to treat urinary-tract diseases, from one side of the membrane to the other." [GOC:jl, GOC:mtg_transport, http://biotech.icmb.utexas.edu/, ISBN:0815340729]


id: GO:0042952
name: beta-ketoadipate pathway
namespace: biological_process
def:
  "A pathway of aromatic compound degradation by ortho-cleavage; one branch converts protocatechuate, derived from phenolic compounds, to beta-ketoadipate, and the other branch converts catechol, generated from various aromatic hydrocarbons, amino aromatics, and lignin monomers, also to beta-ketoadipate. Two additional steps accomplish the conversion of beta-ketoadipate to tricarboxylic acid cycle intermediates." [GOC:jl, PMID:8905091]


id: GO:0042953
name: lipoprotein transport
namespace: biological_process
def:
  "The directed movement of any conjugated, water-soluble protein in which the nonprotein group consists of a lipid or lipids, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl, ISBN:0198506732]


id: GO:0042954
name: lipoprotein transporter activity
namespace: molecular_function
def:
  "Enables the directed movement of any conjugated, water-soluble protein in which the nonprotein group consists of a lipid or lipids, into, out of or within a cell, or between cells." [GOC:jl, ISBN:0198506732]


id: GO:0042955
name: dextrin transport
namespace: biological_process
def:
  "The directed movement of dextrin, any one, or the mixture, of the intermediate polysaccharides formed during the hydrolysis of starch, which are dextrorotatory, soluble in water, and precipitable in alcohol, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl, http://www.mercksource.com/]


id: GO:0042956
name: maltodextrin transport
namespace: biological_process
def:
  "The directed movement of maltodextrin, any polysaccharide of glucose residues in beta-(1,4) linkage, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl, http://www.mercksource.com/]


id: GO:0042957
name: dextrin transmembrane transporter activity
namespace: molecular_function
def:
  "Enables the transfer of dextrin, any one, or the mixture, of the intermediate polysaccharides formed during the hydrolysis of starch, which are dextrorotatory, soluble in water, and precipitable in alcohol, from one side of the membrane to the other." [GOC:jl, GOC:vk, http://www.mercksource.com/]


id: GO:0042958
name: maltodextrin transmembrane transporter activity
namespace: molecular_function
def:
  "Enables the transfer of maltodextrin, any polysaccharide of glucose residues in beta-(1,4) linkage, from one side of the membrane to the other." [GOC:jl, http://www.mercksource.com/, PMID:15034926]


id: GO:0042959
name: alkanesulfonate transporter activity
namespace: molecular_function
def:
  "Enables the directed movement of alkanesulfonate into, out of or within a cell, or between cells." [GOC:jl]


id: GO:0042960
name: antimonite secondary active transmembrane transporter activity
namespace: molecular_function
def:
  "Catalysis of the transfer of antimonite from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport." [GOC:jl]


id: GO:0042961
name: antimonite-transporting ATPase activity
namespace: molecular_function
def:
  "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + antimonite(in) = ADP + phosphate + antimonite(out)." [EC:3.6.3.16]


id: GO:0042962
name: acridine:proton antiporter activity
namespace: molecular_function
def:
  "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + acridine(in) = H+(in) + acridine(out)." [PMID:10735876]


id: GO:0042964
name: thioredoxin biosynthetic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of thioredoxin, a small disulfide-containing redox protein that serves as a general protein disulfide oxidoreductase." [GOC:go_curators]


id: GO:0042965
name: glutaredoxin biosynthetic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of a small disulfide-containing redox protein that serves as a glutathione-disulfide oxidoreductase." [GOC:go_curators]


id: GO:0042966
name: biotin carboxyl carrier protein biosynthetic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of the biotin carboxyl carrier protein, a subunit of acetyl-coenzyme A carboxylase." [GOC:go_curators, PMID:8102363]


id: GO:0042967
name: acyl-carrier-protein biosynthetic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of acyl-carrier protein." [GOC:go_curators]


id: GO:0042968
name: homoserine transport
namespace: biological_process
def:
  "The directed movement of homoserine, alpha-amino-gamma-hydroxybutyric acid, an intermediate in the biosynthesis of cystathionine, threonine and methionine, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:go_curators, ISBN:0198506732]


id: GO:0042969
name: lactone transport
namespace: biological_process
def:
  "The directed movement of lactone from one side of a membrane to the other. A lactone is a cyclic ester of a hydroxy carboxylic acid, containing a 1-oxacycloalkan-2-one structure, or an analogue having unsaturation or heteroatoms replacing one or more carbon atoms of the ring." [CHEBI:25000, GOC:go_curators]


id: GO:0042970
name: homoserine transmembrane transporter activity
namespace: molecular_function
def:
  "Enables the transfer of homoserine from one side of a membrane to the other. Homoserine is alpha-amino-gamma-hydroxybutyric acid, an intermediate in the biosynthesis of cystathionine, threonine and methionine." [GOC:go_curators, ISBN:0198506732]


id: GO:0042971
name: lactone transmembrane transporter activity
namespace: molecular_function
def:
  "Enables the directed movement of lactone from one side of a membrane to the other. A lactone is a cyclic ester of a hydroxy carboxylic acid, containing a 1-oxacycloalkan-2-one structure, or an analogue having unsaturation or heteroatoms replacing one or more carbon atoms of the ring." [CHEBI:25000, GOC:go_curators]


id: GO:0042972
name: licheninase activity
namespace: molecular_function
def:
  "Catalysis of the hydrolysis of (1->4)-beta-D-glucosidic linkages in beta-D-glucans containing (1->3) and (1->4) bonds." [EC:3.2.1.73]


id: GO:0042973
name: glucan endo-1,3-beta-D-glucosidase activity
namespace: molecular_function
def:
  "Catalysis of the hydrolysis of (1->3)-beta-D-glucosidic linkages in (1->3)-beta-D-glucans." [EC:3.2.1.39]


id: GO:0042974
name: retinoic acid receptor binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with the retinoic acid receptor, a ligand-regulated transcription factor belonging to the nuclear receptor superfamily." [GOC:jl, PMID:12476796]


id: GO:0042975
name: peroxisome proliferator activated receptor binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with any of the peroxisome proliferator activated receptors, alpha, beta or gamma." [GOC:jl, PMID:12769781]


id: GO:0042976
name: activation of Janus kinase activity
namespace: biological_process
def:
  "The process of introducing a phosphate group to a tyrosine residue of a JAK (Janus Activated Kinase) protein, thereby activating it." [GOC:jl, PMID:12479803]


id: GO:0042977
name: activation of JAK2 kinase activity
namespace: biological_process
def:
  "The process of introducing a phosphate group to a tyrosine residue of a JAK2 (Janus Activated Kinase 2) protein, thereby activating it." [GOC:jl, PMID:12479803]


id: GO:0042980
name: obsolete cystic fibrosis transmembrane conductance regulator binding
namespace: molecular_function
def:
  "OBSOLETE. Interacting selectively and non-covalently with the Cystic Fibrosis Transmembrane conductance Regulator (CFTR) protein." [GOC:jl]


id: GO:0042981
name: regulation of apoptotic process
namespace: biological_process
def:
  "Any process that modulates the occurrence or rate of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]


id: GO:0042982
name: amyloid precursor protein metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving amyloid precursor protein (APP), the precursor of beta-amyloid, a glycoprotein associated with Alzheimer's disease." [GOC:go_curators]


id: GO:0042983
name: amyloid precursor protein biosynthetic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of amyloid precursor protein (APP), the precursor of beta-amyloid, a glycoprotein associated with Alzheimer's disease." [GOC:go_curators]


id: GO:0042984
name: regulation of amyloid precursor protein biosynthetic process
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of amyloid precursor protein (APP), the precursor of beta-amyloid." [GOC:go_curators]


id: GO:0042985
name: negative regulation of amyloid precursor protein biosynthetic process
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of amyloid precursor protein (APP), the precursor of beta-amyloid." [GOC:go_curators]


id: GO:0042986
name: positive regulation of amyloid precursor protein biosynthetic process
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of amyloid precursor protein (APP), the precursor of beta-amyloid." [GOC:go_curators]


id: GO:0042987
name: amyloid precursor protein catabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the breakdown of amyloid precursor protein (APP), the precursor of beta-amyloid, a glycoprotein associated with Alzheimer's disease." [GOC:go_curators]


id: GO:0042988
name: X11-like protein binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with X11-like protein, a neuron-specific adaptor protein." [GOC:jl, PMID:12780348]


id: GO:0042989
name: sequestering of actin monomers
namespace: biological_process
def:
  "The selective interaction of actin monomers with specific molecules that inhibit their polymerization by preventing their access to other monomers." [GOC:go_curators]


id: GO:0042990
name: regulation of transcription factor import into nucleus
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of the movement of a transcription factor from the cytoplasm to the nucleus." [GOC:jl]


id: GO:0042992
name: negative regulation of transcription factor import into nucleus
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of the movement of a transcription factor from the cytoplasm to the nucleus." [GOC:jl]


id: GO:0042993
name: positive regulation of transcription factor import into nucleus
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of the movement of a transcription factor from the cytoplasm to the nucleus." [GOC:jl]


id: GO:0042994
name: cytoplasmic sequestering of transcription factor
namespace: biological_process
def:
  "The selective interaction of a transcription factor with specific molecules in the cytoplasm, thereby inhibiting its translocation into the nucleus." [GOC:jl]


id: GO:0042995
name: cell projection
namespace: cellular_component
def:
  "A prolongation or process extending from a cell, e.g. a flagellum or axon." [GOC:jl, http://www.cogsci.princeton.edu/~wn/]


id: GO:0042996
name: regulation of Golgi to plasma membrane protein transport
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of the transport of proteins from the Golgi to the plasma membrane." [GOC:jl]


id: GO:0042997
name: negative regulation of Golgi to plasma membrane protein transport
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of the transport of proteins from the Golgi to the plasma membrane." [GOC:jl]


id: GO:0042998
name: positive regulation of Golgi to plasma membrane protein transport
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of the transport of proteins from the Golgi to the plasma membrane." [GOC:jl]


id: GO:0042999
name: regulation of Golgi to plasma membrane CFTR protein transport
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of transport of Cystic Fibrosis Transmembrane conductance Regulator (CFTR) protein from the Golgi to the plasma membrane." [GOC:jl]


id: GO:0043000
name: Golgi to plasma membrane CFTR protein transport
namespace: biological_process
def:
  "The directed movement of Cystic Fibrosis Transmembrane conductance Regulator (CFTR) protein from the Golgi to the plasma membrane." [GOC:jl]


id: GO:0043001
name: Golgi to plasma membrane protein transport
namespace: biological_process
def:
  "The directed movement of proteins from the Golgi to the plasma membrane in transport vesicles that move from the trans-Golgi network to the plasma membrane." [ISBN:0716731363]


id: GO:0043002
name: negative regulation of Golgi to plasma membrane CFTR protein transport
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of transport of Cystic Fibrosis Transmembrane conductance Regulator (CFTR) protein from the Golgi to the plasma membrane." [GOC:jl]


id: GO:0043003
name: positive regulation of Golgi to plasma membrane CFTR protein transport
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of transport of Cystic Fibrosis Transmembrane conductance Regulator (CFTR) protein from the Golgi to the plasma membrane." [GOC:jl]


id: GO:0043004
name: cytoplasmic sequestering of CFTR protein
namespace: biological_process
def:
  "The selective interaction of Cystic Fibrosis Transmembrane conductance Regulator (CFTR) protein with specific molecules in the cytoplasm, thereby inhibiting its transport to the cell membrane." [GOC:jl]


id: GO:0043005
name: neuron projection
namespace: cellular_component
def:
  "A prolongation or process extending from a nerve cell, e.g. an axon or dendrite." [GOC:jl, http://www.cogsci.princeton.edu/~wn/]


id: GO:0043006
name: activation of phospholipase A2 activity by calcium-mediated signaling
namespace: biological_process
def:
  "A series of molecular signals that leads to the upregulation of calcium-dependent phospholipase A2 activity in response to the signal." [GOC:dph, GOC:jl, GOC:tb]


id: GO:0043007
name: maintenance of rDNA
namespace: biological_process
def:
  "Any process involved in sustaining the fidelity and copy number of rDNA repeats." [GOC:vw, PMID:14528010]


id: GO:0043008
name: ATP-dependent protein binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules) using energy from the hydrolysis of ATP." [GOC:jl]


id: GO:0043009
name: chordate embryonic development
namespace: biological_process
def:
  "The process whose specific outcome is the progression of the embryo over time, from zygote formation through a stage including a notochord and neural tube until birth or egg hatching." [GOC:mtg_sensu]


id: GO:0043010
name: camera-type eye development
namespace: biological_process
def:
  "The process whose specific outcome is the progression of the camera-type eye over time, from its formation to the mature structure. The camera-type eye is an organ of sight that receives light through an aperture and focuses it through a lens, projecting it on a photoreceptor field." [GOC:go_curators, GOC:mtg_sensu]


id: GO:0043011
name: myeloid dendritic cell differentiation
namespace: biological_process
def:
  "The process in which a monocyte acquires the specialized features of a dendritic cell, an immunocompetent cell of the lymphoid and hemopoietic systems and skin." [CL:0000782, GOC:jl]


id: GO:0043012
name: regulation of fusion of sperm to egg plasma membrane
namespace: biological_process
def:
  "Any process that modulates the binding and fusion of a sperm to the oocyte plasma membrane." [GOC:jl, http://arbl.cvmbs.colostate.edu/hbooks/pathphys/reprod/fert/fert.html]


id: GO:0043013
name: negative regulation of fusion of sperm to egg plasma membrane
namespace: biological_process
def:
  "Any process that stops or prevents the binding and fusion of a sperm to the oocyte plasma membrane." [GOC:jl, http://arbl.cvmbs.colostate.edu/hbooks/pathphys/reprod/fert/fert.html]


id: GO:0043014
name: alpha-tubulin binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with the microtubule constituent protein alpha-tubulin." [GOC:jl]


id: GO:0043015
name: gamma-tubulin binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with the microtubule constituent protein gamma-tubulin." [GOC:jl]


id: GO:0043016
name: regulation of lymphotoxin A biosynthetic process
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of the cytokine lymphotoxin A." [GOC:jl]


id: GO:0043017
name: positive regulation of lymphotoxin A biosynthetic process
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of the cytokine lymphotoxin A." [GOC:jl]


id: GO:0043018
name: negative regulation of lymphotoxin A biosynthetic process
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of the cytokine lymphotoxin A." [GOC:jl]


id: GO:0043020
name: NADPH oxidase complex
namespace: cellular_component
def:
  "A enzyme complex of which the core is a heterodimer composed of a light (alpha) and heavy (beta) chain, and requires several other water-soluble proteins of cytosolic origin for activity. Functions in superoxide generation by the NADPH-dependent reduction of O2." [GOC:jl, PMID:11483596, PMID:12440767]


id: GO:0043021
name: ribonucleoprotein complex binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with any complex of RNA and protein." [GOC:bf, GOC:go_curators, GOC:vk]


id: GO:0043023
name: ribosomal large subunit binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with any part of the larger ribosomal subunit." [GOC:go_curators]


id: GO:0043024
name: ribosomal small subunit binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with any part of the small ribosomal subunit." [GOC:go_curators]


id: GO:0043025
name: neuronal cell body
namespace: cellular_component
def:
  "The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites." [GOC:go_curators]


id: GO:0043027
name: cysteine-type endopeptidase inhibitor activity involved in apoptotic process
namespace: molecular_function
def:
  "Stops, prevents or reduces the activity of a cysteine-type endopeptidase involved in the apoptotic process." [GOC:jl, GOC:mtg_apoptosis, PMID:14744432, Wikipedia:Caspase]


id: GO:0043028
name: cysteine-type endopeptidase regulator activity involved in apoptotic process
namespace: molecular_function
def:
  "Modulates the activity of a cysteine-type endopeptidase involved in the apoptotic process." [GOC:jl, GOC:mtg_apoptosis, PMID:14744432, Wikipedia:Caspase]


id: GO:0043029
name: T cell homeostasis
namespace: biological_process
def:
  "The process of regulating the proliferation and elimination of T cells such that the total number of T cells within a whole or part of an organism is stable over time in the absence of an outside stimulus." [GOC:mgi_curators, ISBN:0781735149]


id: GO:0043031
name: negative regulation of macrophage activation
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of macrophage activation." [GOC:jl]


id: GO:0043033
name: isoamylase complex
namespace: cellular_component
def:
  "A protein complex whose composition varies amongst species; in rice it probably exists in a homo-tetramer to homo-hexamer form and in Gram-negative bacteria as a dimer. Functions in the hydrolysis of alpha-(1,6)-D-glucosidic branch linkages." [GOC:jl, PMID:10333591]


id: GO:0043034
name: costamere
namespace: cellular_component
def:
  "Regular periodic sub membranous arrays of vinculin in skeletal and cardiac muscle cells, these arrays link Z-discs to the sarcolemma and are associated with links to extracellular matrix." [GOC:jl, GOC:mtg_muscle, ISBN:0198506732, PMID:6405378]


id: GO:0043035
name: chromatin insulator sequence binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently and stoichiometrically with a chromatin insulator sequence, a DNA sequence that prevents enhancer-mediated activation or repression of transcription." [GOC:jl, PMID:12783795]


id: GO:0043036
name: starch grain
namespace: cellular_component
def:
  "Plant storage body for amylose and amylopectin, 1-100um in diameter. Also contains small amounts of enzymes, amino acids, lipids and nucleic acids. The shape of the grain varies widely amongst species, but is often spherical or disk-shaped." [GOC:jl, PMID:11217978]


id: GO:0043038
name: amino acid activation
namespace: biological_process
def:
  "The modification of an amino acid to an active form, for incorporation into a peptide, protein or other macromolecule." [GOC:jl]


id: GO:0043039
name: tRNA aminoacylation
namespace: biological_process
def:
  "The chemical reactions and pathways by which the various amino acids become bonded to their corresponding tRNAs. The most common route for synthesis of aminoacyl tRNA is by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, usually catalyzed by the cognate aminoacyl-tRNA ligase. A given aminoacyl-tRNA ligase aminoacylates all species of an isoaccepting group of tRNA molecules." [GOC:ma, GOC:mah, MetaCyc:Aminoacyl-tRNAs]


id: GO:0043040
name: tRNA aminoacylation for nonribosomal peptide biosynthetic process
namespace: biological_process
def:
  "The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in nonribosomal peptide synthesis." [GOC:jl]


id: GO:0043042
name: amino acid adenylylation by nonribosomal peptide synthase
namespace: biological_process
def:
  "Activation of an amino acid for incorporation into a peptide by a nonribosomal process, catalyzed by subunits of nonribosomal peptide synthase. The amino acid is adenylated at its carboxylate group (ATP-dependent) then transferred to the thiol group of an enzyme-bound phosphopantetheine cofactor." [GOC:jl, PMID:9250661, PMID:9712910]


id: GO:0043043
name: peptide biosynthetic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of peptides, compounds of 2 or more (but usually less than 100) amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another. This may include the translation of a precursor protein and its subsequent processing into a functional peptide." [CHEBI:16670, GOC:dph, GOC:jl]


id: GO:0043044
name: ATP-dependent chromatin remodeling
namespace: biological_process
def:
  "Dynamic structural changes to eukaryotic chromatin that require energy from the hydrolysis of ATP, ranging from local changes necessary for transcriptional regulation to global changes necessary for chromosome segregation, mediated by ATP-dependent chromatin-remodelling factors." [GOC:jl, PMID:12042764]


id: GO:0043045
name: DNA methylation involved in embryo development
namespace: biological_process
def:
  "The covalent transfer of a methyl group to C-5 of cytosine that contributes to the epigenetic regulation of embryonic gene expression." [GOC:go_curators, PMID:12138111]


id: GO:0043046
name: DNA methylation involved in gamete generation
namespace: biological_process
def:
  "The covalent transfer of a methyl group to C-5 of cytosine that contributes to the establishment of DNA methylation patterns in the gamete." [GOC:go_curators, PMID:12138111]


id: GO:0043047
name: single-stranded telomeric DNA binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with single-stranded telomere-associated DNA." [GOC:jl, ISBN:0321000382]


id: GO:0043048
name: dolichyl monophosphate biosynthetic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of dolichyl diphosphate, a phosphorylated dolichol derivative." [GOC:jl]


id: GO:0043049
name: otic placode formation
namespace: biological_process
def:
  "The initial developmental process that will lead to the formation of the vertebrate inner ear. The otic placode forms as a thickening of the head ectoderm adjacent to the developing hindbrain." [GOC:go_curators, PMID:12668634]


id: GO:0043050
name: pharyngeal pumping
namespace: biological_process
def:
  "The contraction and relaxation movements of the pharyngeal muscle that mediate feeding in nematodes." [GOC:cab1, PMID:2181052]


id: GO:0043051
name: regulation of pharyngeal pumping
namespace: biological_process
def:
  "Any process that modulates the contraction and relaxation movements of the pharyngeal muscle that mediates feeding in nematodes." [GOC:cab1, PMID:2181052]


id: GO:0043052
name: thermotaxis
namespace: biological_process
def:
  "The directed movement of a motile cell or organism in response to a temperature gradient. Movement may be towards either a higher or lower temperature." [GOC:cab1, WB_REF:cgc467]


id: GO:0043053
name: dauer entry
namespace: biological_process
def:
  "Entry into the facultative diapause of the dauer (enduring) larval stage of nematode development." [GOC:cab1, GOC:kmv, PMID:10077613]


id: GO:0043054
name: dauer exit
namespace: biological_process
def:
  "Exit from the facultative diapause of the dauer (enduring) larval stage of nematode development." [GOC:cab1, PMID:12620986]


id: GO:0043055
name: maintenance of dauer
namespace: biological_process
def:
  "Maintenance of a nematode during the facultative diapause of the dauer (enduring) larval stage of nematode development." [GOC:cab1, WB_REF:wm2003ab740]


id: GO:0043056
name: forward locomotion
namespace: biological_process
def:
  "Anterior movement of an organism, following the direction of the head of the animal." [GOC:go_curators]


id: GO:0043057
name: backward locomotion
namespace: biological_process
def:
  "Posterior movement of an organism, e.g. following the direction of the tail of an animal." [GOC:go_curators]


id: GO:0043058
name: regulation of backward locomotion
namespace: biological_process
def:
  "Any process that modulates the speed, mechanical force, or rhythm of the posterior movement of an organism." [GOC:go_curators]


id: GO:0043059
name: regulation of forward locomotion
namespace: biological_process
def:
  "Any process that modulates the speed, mechanical force, or rhythm of the anterior movement of an organism." [GOC:go_curators]


id: GO:0043060
name: meiotic metaphase I plate congression
namespace: biological_process
def:
  "The alignment of chromosomes at the metaphase plate, a plane halfway between the poles of the meiotic spindle, during meiosis I." [GOC:cab1, PMID:10809666]


id: GO:0043061
name: meiotic metaphase II plate congression
namespace: biological_process
def:
  "The alignment of chromosomes at the metaphase plate, a plane halfway between the poles of the meiotic spindle, during meiosis II." [GOC:cab1, PMID:10809666]


id: GO:0043062
name: extracellular structure organization
namespace: biological_process
def:
  "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of structures in the space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane, and also covers the host cell environment outside an intracellular parasite." [GOC:ai, GOC:dph, GOC:jl, GOC:mah]


id: GO:0043063
name: intercellular bridge organization
namespace: biological_process
def:
  "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the intracellular bridge. An intracellular bridge is a direct link between the cytoplasms of sister cells that allows cells to communicate with one another." [GOC:jid]


id: GO:0043064
name: obsolete flagellum organization
namespace: biological_process
def:
  "OBSOLETE. A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a flagellum, a long thin projection from a cell, used in movement." [GOC:curators, ISBN:0815316194]


id: GO:0043065
name: positive regulation of apoptotic process
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]


id: GO:0043066
name: negative regulation of apoptotic process
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process." [GOC:jl, GOC:mtg_apoptosis]


id: GO:0043067
name: regulation of programmed cell death
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes." [GOC:jl]


id: GO:0043068
name: positive regulation of programmed cell death
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes." [GOC:jl]


id: GO:0043069
name: negative regulation of programmed cell death
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of programmed cell death, cell death resulting from activation of endogenous cellular processes." [GOC:jl]


id: GO:0043073
name: germ cell nucleus
namespace: cellular_component
def:
  "The nucleus of a germ cell, a reproductive cell in multicellular organisms." [CL:0000586, GOC:go_curators]


id: GO:0043076
name: megasporocyte nucleus
namespace: cellular_component
def:
  "The nucleus of a megasporocyte, a diploid cell that undergoes meiosis to produce four megaspores, and its descendents." [GOC:jl, ISBN:0618254153]


id: GO:0043077
name: initiation of acetate catabolic process
namespace: biological_process
def:
  "The activation of the chemical reactions and pathways resulting in the breakdown of acetate." [GOC:jl]


id: GO:0043078
name: polar nucleus
namespace: cellular_component
def:
  "Either of two nuclei located centrally in a flowering plant embryo sac that eventually fuse to form the endosperm nucleus." [ISBN:0618254153]


id: GO:0043079
name: antipodal cell nucleus
namespace: cellular_component
def:
  "The nucleus of an antipodal cell, one of three cells of the embryo sac in angiosperms, found at the chalazal end of the embryo away from the point of entry of the pollen tube, and its descendents." [CL:0000537, GOC:jl]


id: GO:0043082
name: megagametophyte egg cell nucleus
namespace: cellular_component
def:
  "The nucleus of a plant egg cell. This nucleus is found at the micropylar end of the embryo." [GOC:jl, GOC:mtg_sensu]


id: GO:0043083
name: synaptic cleft
namespace: cellular_component
def:
  "The narrow gap that separates the presynaptic and postsynaptic membranes, into which neurotransmitter is released." [GOC:jl, http://synapses.mcg.edu/anatomy/chemical/synapse.stm]


id: GO:0043084
name: penile erection
namespace: biological_process
def:
  "The hardening, enlarging and rising of the penis which often occurs in the sexually aroused male and enables sexual intercourse. Achieved by increased inflow of blood into the vessels of erectile tissue, and decreased outflow." [GOC:jl, Wikipedia:Penile_erection]


id: GO:0043091
name: L-arginine import
namespace: biological_process
def:
  "The directed movement of L-arginine, the L-enantiomer of 2-amino-5-guanidinopentanoic acid, into a cell or organelle." [GOC:jl, GOC:jsg, GOC:mah]


id: GO:0043092
name: L-amino acid import
namespace: biological_process
def:
  "The directed movement of L-enantiomer amino acids into a cell or organelle." [GOC:jl, GOC:jsg, GOC:mah]


id: GO:0043093
name: FtsZ-dependent cytokinesis
namespace: biological_process
def:
  "A cytokinesis process that involves a set of conserved proteins including FtsZ, and results in the formation of two similarly sized and shaped cells." [GOC:mah, ISBN:0815108893, PMID:12626683]


id: GO:0043094
name: cellular metabolic compound salvage
namespace: biological_process
def:
  "Any process which produces a useful metabolic compound from derivatives of it without de novo synthesis, as carried out by individual cells." [GOC:mlg]


id: GO:0043096
name: purine nucleobase salvage
namespace: biological_process
def:
  "Any process that generates purine nucleobases, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, from derivatives of them without de novo synthesis." [CHEBI:26386, GOC:jl]


id: GO:0043097
name: pyrimidine nucleoside salvage
namespace: biological_process
def:
  "Any process that generates a pyrimidine nucleoside, one of a family of organic molecules consisting of a pyrimidine base covalently bonded to a sugar ribose, from derivatives of it, without de novo synthesis." [GOC:jl]


id: GO:0043098
name: purine deoxyribonucleoside salvage
namespace: biological_process
def:
  "Any process which produces a purine deoxyribonucleoside from derivatives of it, without de novo synthesis." [GOC:jl]


id: GO:0043099
name: pyrimidine deoxyribonucleoside salvage
namespace: biological_process
def:
  "Any process that generates a pyrimidine deoxyribonucleoside from derivatives of it, without de novo synthesis." [GOC:jl]


id: GO:0043100
name: pyrimidine nucleobase salvage
namespace: biological_process
def:
  "Any process that generates pyrimidine nucleobases, 1,3-diazine organic nitrogenous bases, from derivatives of them without de novo synthesis." [CHEBI:26432, GOC:jl]


id: GO:0043101
name: purine-containing compound salvage
namespace: biological_process
def:
  "Any process that generates a purine-containing compound, any nucleobase, nucleoside, nucleotide or nucleic acid that contains a purine base, from derivatives of them without de novo synthesis." [CHEBI:26401, GOC:jl]


id: GO:0043102
name: amino acid salvage
namespace: biological_process
def:
  "Any process which produces an amino acid from derivatives of it, without de novo synthesis." [GOC:jl]


id: GO:0043103
name: hypoxanthine salvage
namespace: biological_process
def:
  "Any process that generates hypoxanthine, 6-hydroxy purine, from derivatives of it without de novo synthesis." [GOC:jl, ISBN:0198506732]


id: GO:0043107
name: type IV pilus-dependent motility
namespace: biological_process
def:
  "Any process involved in the controlled movement of a bacterial cell which is dependent on the presence of type IV pili. Includes social gliding motility and twitching motility." [GOC:go_curators, PMID:12704238]


id: GO:0043110
name: rDNA spacer replication fork barrier binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with replication fork barriers found in rDNA spacers, sites that inhibit replication forks in the direction opposite to rDNA transcription." [GOC:jl, GOC:mah, PMID:14645529]


id: GO:0043111
name: replication fork arrest
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of DNA replication by impeding the progress of the DNA replication fork." [GOC:jl, PMID:14645529]


id: GO:0043112
name: receptor metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:jl]


id: GO:0043113
name: receptor clustering
namespace: biological_process
def:
  "The receptor metabolic process that results in grouping of a set of receptors at a cellular location, often to amplify the sensitivity of a signaling response." [GOC:bf, GOC:jl, GOC:pr, PMID:19747931, PMID:21453460]


id: GO:0043115
name: precorrin-2 dehydrogenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: NAD(+) + precorrin-2 = 2 H(+) + NADH + sirohydrochlorin." [EC:1.3.1.76, RHEA:15616]


id: GO:0043120
name: tumor necrosis factor binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with tumor necrosis factor, a proinflammatory cytokine produced by monocytes and macrophages." [GOC:jl, http://lookwayup.com/]


id: GO:0043121
name: neurotrophin binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with a neurotrophin, any of a family of growth factors that prevent apoptosis in neurons and promote nerve growth." [GOC:jl, http://www.mercksource.com/, PR:000021998]


id: GO:0043123
name: positive regulation of I-kappaB kinase/NF-kappaB signaling
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of I-kappaB kinase/NF-kappaB signaling." [GOC:jl]


id: GO:0043124
name: negative regulation of I-kappaB kinase/NF-kappaB signaling
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of -kappaB kinase/NF-kappaB signaling." [GOC:jl]


id: GO:0043125
name: ErbB-3 class receptor binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with the protein-tyrosine kinase receptor ErbB-3/HER3." [GOC:jl]


id: GO:0043127
name: negative regulation of 1-phosphatidylinositol 4-kinase activity
namespace: biological_process
def:
  "Any process that stops or reduces the activity of the enzyme 1-phosphatidylinositol 4-kinase." [GOC:jl]


id: GO:0043129
name: surfactant homeostasis
namespace: biological_process
def:
  "Any process involved in the maintenance of a steady-state level of the surface-active lipoprotein mixture which coats the alveoli." [PMID:9751757]


id: GO:0043130
name: ubiquitin binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with ubiquitin, a protein that when covalently bound to other cellular proteins marks them for proteolytic degradation." [GOC:ecd]


id: GO:0043131
name: erythrocyte enucleation
namespace: biological_process
def:
  "The process in which nucleated precursor cells lose their nucleus during erythrocyte maturation." [GOC:hjd]


id: GO:0043132
name: NAD transport
namespace: biological_process
def:
  "The directed movement of nicotinamide adenine dinucleotide into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore; transport may be of either the oxidized form, NAD, or the reduced form, NADH." [GOC:jl]


id: GO:0043133
name: hindgut contraction
namespace: biological_process
def:
  "A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the hindgut. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The hindgut is the posterior part of the alimentary canal, including the rectum, and the large intestine." [GOC:jl, GOC:mtg_muscle, UBERON:0001046]


id: GO:0043134
name: regulation of hindgut contraction
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of muscle contraction of the hindgut, the posterior part of the alimentary canal, including the rectum, and the large intestine." [GOC:jl, UBERON:0001046]


id: GO:0043135
name: 5-phosphoribosyl 1-pyrophosphate pyrophosphatase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 5-phospho-alpha-D-ribose 1-diphosphate + H2O = ribose 1,5 bisphosphate + phosphate + H+." [MetaCyc:RXN-10969, PMID:12370170]


id: GO:0043137
name: DNA replication, removal of RNA primer
namespace: biological_process
def:
  "Removal of the Okazaki RNA primer from the lagging strand of replicating DNA, by a combination of the actions of DNA polymerase, DNA helicase and an endonuclease." [GOC:jl, PMID:12424238]


id: GO:0043140
name: ATP-dependent 3'-5' DNA helicase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: ATP + H2O = ADP + phosphate; drives the unwinding of the DNA helix in the direction 3' to 5'." [GOC:jl]


id: GO:0043141
name: ATP-dependent 5'-3' DNA helicase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: ATP + H2O = ADP + phosphate; drives the unwinding of the DNA helix in the direction 5' to 3'." [GOC:jl]


id: GO:0043142
name: single-stranded DNA-dependent ATPase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction requires the presence of single-stranded DNA, and it drives another reaction." [GOC:go_curators]


id: GO:0043143
name: regulation of translation by machinery localization
namespace: biological_process
def:
  "Any process in which proteins and protein complexes involved in translation are transported to, or maintained in, a specific location." [GOC:jl]


id: GO:0043144
name: snoRNA processing
namespace: biological_process
def:
  "Any process involved in the conversion of a primary small nucleolar RNA (snoRNA) transcript into a mature snoRNA." [GOC:go_curators, PMID:12773397]


id: GO:0043145
name: snoRNA 3'-end cleavage
namespace: biological_process
def:
  "The endonucleolytic cleavage of snoRNA 3' ends, which is required for mature snoRNAs to be functional." [GOC:go_curators, PMID:12773397]


id: GO:0043147
name: meiotic spindle stabilization
namespace: biological_process
def:
  "The cell cycle process in which spindle integrity is maintained during M phase of meiosis." [GOC:go_curators]


id: GO:0043148
name: mitotic spindle stabilization
namespace: biological_process
def:
  "The cell cycle process in which spindle integrity is maintained during M phase of mitosis." [GOC:go_curators]


id: GO:0043149
name: stress fiber assembly
namespace: biological_process
def:
  "The aggregation, arrangement and bonding together of a set of components to form a stress fiber. A stress fiber is a contractile actin filament bundle that consists of short actin filaments with alternating polarity." [GOC:go_curators, GOC:mah, PMID:16651381]


id: GO:0043150
name: DNA synthesis involved in double-strand break repair via homologous recombination
namespace: biological_process
def:
  "The synthesis of DNA that contributes to the process of double-strand break repair via homologous recombination." [GOC:go_curators]


id: GO:0043151
name: DNA synthesis involved in double-strand break repair via single-strand annealing
namespace: biological_process
def:
  "The synthesis of DNA that contributes to the process of double-strand break repair via single-strand annealing." [GOC:go_curators]


id: GO:0043153
name: entrainment of circadian clock by photoperiod
namespace: biological_process
def:
  "The synchronization of a circadian rhythm to photoperiod, the intermittent cycle of light (day) and dark (night)." [GOC:jl]


id: GO:0043154
name: negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of a cysteine-type endopeptidase activity involved in the apoptotic process." [GOC:jl, GOC:mtg_apoptosis]


id: GO:0043155
name: negative regulation of photosynthesis, light reaction
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of the light-dependent reaction of photosynthesis." [GOC:jl]


id: GO:0043156
name: chromatin remodeling in response to cation stress
namespace: biological_process
def:
  "Structural changes to eukaryotic chromatin occurring as a result of cation stress, an increase or decrease in the concentration of positively charged ions in the environment." [GOC:jl, GOC:vw, PMID:14762213]


id: GO:0043157
name: response to cation stress
namespace: biological_process
def:
  "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of cation stress, an increase or decrease in the concentration of positively charged ions in the environment." [GOC:jl, PMID:14762213]


id: GO:0043158
name: heterocyst differentiation
namespace: biological_process
def:
  "The process in which a relatively unspecialized cell acquires specialized features of a heterocyst, a differentiated cell in certain cyanobacteria whose purpose is to fix nitrogen." [GOC:jl]


id: GO:0043159
name: acrosomal matrix
namespace: cellular_component
def:
  "A structural framework, or 'dense core' at the interior of an acrosome. May regulate the distribution of hydrolases within the acrosome and their release during the acrosome reaction." [GOC:jl, PMID:8949900, PMID:9139729]


id: GO:0043161
name: proteasome-mediated ubiquitin-dependent protein catabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:go_curators]


id: GO:0043162
name: ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the breakdown of a protein or peptide covalently tagged with ubiquitin, via the multivesicular body (MVB) sorting pathway; ubiquitin-tagged proteins are sorted into MVBs, and delivered to a lysosome/vacuole for degradation." [GOC:jl, PMID:11511343]


id: GO:0043163
name: cell envelope organization
namespace: biological_process
def:
  "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the cell envelope, everything external to, but not including, the cytoplasmic membrane of bacteria, encompassing the periplasmic space, cell wall, and outer membrane if present." [GOC:jl]


id: GO:0043164
name: Gram-negative-bacterium-type cell wall biogenesis
namespace: biological_process
def:
  "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cell wall of the type found in Gram-negative bacteria. The cell wall is the rigid or semi-rigid envelope lying outside the cell membrane." [GOC:jl, GOC:mtg_sensu, ISBN:0815108893]


id: GO:0043165
name: Gram-negative-bacterium-type cell outer membrane assembly
namespace: biological_process
def:
  "The assembly of an outer membrane of the type formed in Gram-negative bacteria. This membrane is enriched in polysaccharide and protein, and the outer leaflet of the membrane contains specific lipopolysaccharide structures." [GOC:jl, ISBN:0135712254]


id: GO:0043168
name: anion binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with anions, charged atoms or groups of atoms with a net negative charge." [GOC:jl]


id: GO:0043169
name: cation binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with cations, charged atoms or groups of atoms with a net positive charge." [GOC:jl]


id: GO:0043170
name: macromolecule metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [CHEBI:33694, GOC:mah]


id: GO:0043171
name: peptide catabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the breakdown of peptides, compounds of 2 or more (but usually less than 100) amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another." [GOC:jl]


id: GO:0043172
name: ferredoxin biosynthetic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of ferredoxin, any simple, nonenzymatic iron-sulfur protein that is characterized by having equal numbers of atoms of iron and labile sulfur. Iron and sulfur atoms are present in one or two clusters of two or four atoms of each." [GOC:jl, ISBN:0198506732]


id: GO:0043173
name: nucleotide salvage
namespace: biological_process
def:
  "Any process which produces a nucleotide, a compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety, from derivatives of it without de novo synthesis." [GOC:jl]


id: GO:0043174
name: nucleoside salvage
namespace: biological_process
def:
  "Any process which produces a nucleotide, a nucleobase linked to either beta-D-ribofuranose (ribonucleoside) or 2-deoxy-beta-D-ribofuranose (a deoxyribonucleotide), from derivatives of it without de novo synthesis." [GOC:jl]


id: GO:0043175
name: RNA polymerase core enzyme binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with an RNA polymerase core enzyme, containing a specific subunit composition defined as the core enzyme." [GOC:jl, GOC:txnOH]


id: GO:0043176
name: amine binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with any organic compound that is weakly basic in character and contains an amino or a substituted amino group." [GOC:jl]


id: GO:0043177
name: organic acid binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with an organic acid, any acidic compound containing carbon in covalent linkage." [GOC:jl, ISBN:0198506732]


id: GO:0043178
name: alcohol binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with an alcohol, any of a class of alkyl compounds containing a hydroxyl group." [GOC:jl, ISBN:0198506732]


id: GO:0043179
name: rhythmic excitation
namespace: biological_process
def:
  "Any process involved in the generation of rhythmic, synchronous excitatory synaptic inputs in a neural circuit." [GOC:go_curators, ISBN:0195088433]


id: GO:0043180
name: rhythmic inhibition
namespace: biological_process
def:
  "Any process involved in the generation of rhythmic, synchronous inhibitory synaptic inputs in a neural circuit." [GOC:go_curators]


id: GO:0043183
name: vascular endothelial growth factor receptor 1 binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with vascular endothelial growth factor receptor 1." [GOC:st]


id: GO:0043184
name: vascular endothelial growth factor receptor 2 binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with vascular endothelial growth factor receptor 2." [GOC:st]


id: GO:0043185
name: vascular endothelial growth factor receptor 3 binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with vascular endothelial growth factor receptor 3." [GOC:st]


id: GO:0043186
name: P granule
namespace: cellular_component
def:
  "A small cytoplasmic, non-membranous RNA/protein complex aggregates in the primordial germ cells of many higher eukaryotes." [GOC:dph, GOC:kmv, PMID:11262230]


id: GO:0043187
name: cell septum surface
namespace: cellular_component
def:
  "The extracellular (rather than the intracellular) exterior of a dividing septum; this surface is usually composed of cell wall material, for example, lineal (1,3)-beta-D-glucan in S. pombe." [GOC:go_curators]


id: GO:0043190
name: ATP-binding cassette (ABC) transporter complex
namespace: cellular_component
def:
  "A complex for the transport of metabolites into and out of the cell, typically comprised of four domains; two membrane-associated domains and two ATP-binding domains at the intracellular face of the membrane, that form a central pore through the plasma membrane. Each of the four core domains may be encoded as a separate polypeptide or the domains can be fused in any one of a number of ways into multidomain polypeptides. In Bacteria and Archaebacteria, ABC transporters also include substrate binding proteins to bind substrate external to the cytoplasm and deliver it to the transporter." [GOC:jl, GOC:mtg_sensu, PMID:11421269, PMID:15111107]


id: GO:0043194
name: axon initial segment
namespace: cellular_component
def:
  "Portion of the axon proximal to the neuronal cell body, at the level of the axon hillock. The action potentials that propagate along the axon are generated at the level of this initial segment." [GOC:nln, GOC:sl, PMID:1754851, PMID:21551097]


id: GO:0043195
name: terminal bouton
namespace: cellular_component
def:
  "Terminal inflated portion of the axon, containing the specialized apparatus necessary to release neurotransmitters. The axon terminus is considered to be the whole region of thickening and the terminal bouton is a specialized region of it." [GOC:dph, GOC:mc, GOC:nln, PMID:10218156, PMID:8409967]


id: GO:0043196
name: varicosity
namespace: cellular_component
def:
  "Non-terminal inflated portion of the axon, containing the specialized apparatus necessary to release neurotransmitters." [GOC:nln]


id: GO:0043197
name: dendritic spine
namespace: cellular_component
def:
  "A small, membranous protrusion from a dendrite that forms a postsynaptic compartment - typically receiving input from a single presynapse.  They function as partially isolated biochemical and an electrical compartments. Spine morphology is variable including \"thin\", \"stubby\", \"mushroom\", and \"branched\", with a continuum of intermediate morphologies. They typically terminate in a bulb shape, linked to the dendritic shaft by a restriction. Spine remodeling is though to be involved in synaptic plasticity." [GOC:nln]


id: GO:0043198
name: dendritic shaft
namespace: cellular_component
def:
  "Cylindric portion of the dendrite, directly stemming from the perikaryon, and carrying the dendritic spines." [GOC:nln]


id: GO:0043199
name: sulfate binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with sulfate, SO4(2-), a negatively charged small molecule." [GOC:mlg]


id: GO:0043200
name: response to amino acid
namespace: biological_process
def:
  "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amino acid stimulus. An amino acid is a carboxylic acids containing one or more amino groups." [CHEBI:33709, GOC:ef, GOC:mlg]


id: GO:0043201
name: response to leucine
namespace: biological_process
def:
  "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a leucine stimulus." [GOC:mlg]


id: GO:0043206
name: extracellular fibril organization
namespace: biological_process
def:
  "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of extracellular fibrils, extracellular matrix material consisting of polysaccharides and/or proteins." [GOC:mlg, GOC:pr]


id: GO:0043207
name: response to external biotic stimulus
namespace: biological_process
def:
  "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an external biotic stimulus, an external stimulus caused by, or produced by living things." [GOC:go_curators]


id: GO:0043208
name: glycosphingolipid binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with glycosphingolipid, a compound with residues of sphingoid and at least one monosaccharide." [GOC:jl]


id: GO:0043209
name: myelin sheath
namespace: cellular_component
def:
  "An electrically insulating fatty layer that surrounds the axons of many neurons. It is an outgrowth of glial cells: Schwann cells supply the myelin for peripheral neurons while oligodendrocytes supply it to those of the central nervous system." [GOC:cjm, GOC:jl, NIF_Subcellular:sao-593830697, Wikipedia:Myelin]


id: GO:0043210
name: alkanesulfonate binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with alkanesulfonates, the anion of alkanesulfonic acids, sulfonic acid derivatives containing an aliphatic hydrocarbon group." [GOC:mlg]


id: GO:0043211
name: carbohydrate-transporting ATPase activity
namespace: molecular_function
def:
  "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of carbohydrates across a membrane." [GOC:mlg]


id: GO:0043212
name: carbohydrate-exporting ATPase activity
namespace: molecular_function
def:
  "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + carbohydrate(in) -> ADP + phosphate + carbohydrate(out)." [GOC:mlg]


id: GO:0043213
name: bacteriocin transport
namespace: biological_process
def:
  "The directed movement of a bacteriocin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Bacteriocins are a group of antibiotics produced by bacteria and are encoded by a group of naturally occurring plasmids, e.g. Col E1. Bacteriocins are toxic to bacteria closely related to the bacteriocin producing strain." [GOC:mlg]


id: GO:0043214
name: bacteriocin-transporting ATPase activity
namespace: molecular_function
def:
  "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate; drives the transport of bacteriocins across a membrane." [GOC:mlg]


id: GO:0043215
name: daunorubicin transport
namespace: biological_process
def:
  "The directed movement of daunorubicin, an anthracycline antibiotic produced by Streptomyces coeruleorubidus or S. peucetius and used as an antineoplastic into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl, GOC:mlg, http://www.mercksource.com/]


id: GO:0043216
name: daunorubicin-transporting ATPase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: ATP + H2O + daunorubicin(in) = ADP + phosphate + daunorubicin(out)." [GOC:mlg]


id: GO:0043217
name: myelin maintenance
namespace: biological_process
def:
  "The process of preserving the structure and function of mature myelin. This includes maintaining the compact structure of myelin necessary for its electrical insulating characteristics as well as the structure of non-compact regions such as Schmidt-Lantermann clefts and paranodal loops. This does not include processes responsible for maintaining the nodes of Ranvier, which are not part of the myelin sheath." [GOC:dgh]


id: GO:0043218
name: compact myelin
namespace: cellular_component
def:
  "The portion of the myelin sheath in which layers of cell membrane are tightly juxtaposed, completely excluding cytoplasm. The juxtaposed cytoplasmic surfaces form the major dense line, while the juxtaposed extracellular surfaces form the interperiod line visible in electron micrographs." [GOC:dgh, NIF_Subcellular:sao-1123256993]


id: GO:0043219
name: lateral loop
namespace: cellular_component
def:
  "Non-compact myelin located adjacent to the nodes of Ranvier in a myelin segment. These non-compact regions include cytoplasm from the cell responsible for synthesizing the myelin. Lateral loops are found in the paranodal region adjacent to the nodes of Ranvier, while Schmidt-Lantermann clefts are analogous structures found within the compact myelin internode." [GOC:dgh]


id: GO:0043220
name: Schmidt-Lanterman incisure
namespace: cellular_component
def:
  "Regions within compact myelin in which the cytoplasmic faces of the enveloping myelin sheath are not tightly juxtaposed, and include cytoplasm from the cell responsible for making the myelin. Schmidt-Lanterman incisures occur in the compact myelin internode, while lateral loops are analogous structures found in the paranodal region adjacent to the nodes of Ranvier." [GOC:dgh]


id: GO:0043221
name: SMC family protein binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with any protein from the structural maintenance of chromosomes (SMC) family, a group of chromosomal ATPases with a role in mitotic chromosome organization." [GOC:jl, GOC:vw, InterPro:IPR024704, PMID:9640531]


id: GO:0043223
name: cytoplasmic SCF ubiquitin ligase complex
namespace: cellular_component
def:
  "A ubiquitin ligase complex, located in the cytoplasm, in which a cullin from the Cul1 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a Skp1 adaptor and an F-box protein. SCF complexes are involved in targeting proteins for degradation by the proteasome. The best characterized complexes are those from yeast and mammals (with core subunits named Cdc53/Cul1, Rbx1/Hrt1/Roc1)." [PMID:15571813, PMID:15688063]


id: GO:0043224
name: nuclear SCF ubiquitin ligase complex
namespace: cellular_component
def:
  "A ubiquitin ligase complex, located in the nucleus, in which a cullin from the Cul1 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a Skp1 adaptor and an F-box protein. SCF complexes are involved in targeting proteins for degradation by the proteasome. The best characterized complexes are those from yeast and mammals (with core subunits named Cdc53/Cul1, Rbx1/Hrt1/Roc1)." [PMID:15571813, PMID:15688063]


id: GO:0043225
name: anion transmembrane-transporting ATPase activity
namespace: molecular_function
def:
  "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + anion(out) = ADP + phosphate + anion(in)." [GOC:mlg]


id: GO:0043226
name: organelle
namespace: cellular_component
def:
  "Organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, and prokaryotic structures such as anammoxosomes and pirellulosomes. Excludes the plasma membrane." [GOC:go_curators]


id: GO:0043227
name: membrane-bounded organelle
namespace: cellular_component
def:
  "Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane." [GOC:go_curators]


id: GO:0043228
name: non-membrane-bounded organelle
namespace: cellular_component
def:
  "Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane. Includes ribosomes, the cytoskeleton and chromosomes." [GOC:go_curators]


id: GO:0043229
name: intracellular organelle
namespace: cellular_component
def:
  "Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane." [GOC:go_curators]


id: GO:0043230
name: extracellular organelle
namespace: cellular_component
def:
  "Organized structure of distinctive morphology and function, occurring outside the cell. Includes, for example, extracellular membrane vesicles (EMVs) and the cellulosomes of anaerobic bacteria and fungi." [GOC:jl, PMID:9914479]


id: GO:0043231
name: intracellular membrane-bounded organelle
namespace: cellular_component
def:
  "Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane." [GOC:go_curators]


id: GO:0043232
name: intracellular non-membrane-bounded organelle
namespace: cellular_component
def:
  "Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane and occurring within the cell. Includes ribosomes, the cytoskeleton and chromosomes." [GOC:go_curators]


id: GO:0043233
name: organelle lumen
namespace: cellular_component
def:
  "The internal volume enclosed by the membranes of a particular organelle; includes the volume enclosed by a single organelle membrane, e.g. endoplasmic reticulum lumen, or the volume enclosed by the innermost of the two lipid bilayers of an organelle envelope, e.g. nuclear lumen." [GOC:jl, GOC:mah]


id: GO:0043234
name: protein complex
namespace: cellular_component
def:
  "A stable macromolecular complex composed (only) of two or more polypeptide subunits along with any covalently attached molecules (such as lipid anchors or oligosaccharide) or non-protein prosthetic groups (such as nucleotides or metal ions). Prosthetic group in this context refers to a tightly bound cofactor. The component polypeptide subunits may be identical." [GOC:go_curators, http://www.ebi.ac.uk/intact/complex/documentation/]


id: GO:0043235
name: receptor complex
namespace: cellular_component
def:
  "Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:go_curators]


id: GO:0043236
name: laminin binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with laminins, glycoproteins that are major constituents of the basement membrane of cells." [GOC:ecd]


id: GO:0043237
name: laminin-1 binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with laminin-1, a glycoprotein trimer with the subunit composition alpha1, beta1, gamma1." [GOC:go_curators]


id: GO:0043240
name: Fanconi anaemia nuclear complex
namespace: cellular_component
def:
  "A protein complex composed of the Fanconi anaemia (FA) proteins including A, C, E, G and F (FANCA-F). Functions in the activation of the downstream protein FANCD2 by monoubiquitylation, and is essential for protection against chromosome breakage." [GOC:jl, PMID:12093742]


id: GO:0043241
name: protein complex disassembly
namespace: biological_process
def:
  "The disaggregation of a protein complex into its constituent components. Protein complexes may have other associated non-protein prosthetic groups, such as nucleic acids, metal ions or carbohydrate groups." [GOC:jl]


id: GO:0043242
name: negative regulation of protein complex disassembly
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of protein complex disassembly, the disaggregation of a protein complex into its constituent components." [GOC:jl]


id: GO:0043243
name: positive regulation of protein complex disassembly
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of protein complex disassembly, the disaggregation of a protein complex into its constituent components." [GOC:jl]


id: GO:0043244
name: regulation of protein complex disassembly
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of protein complex disassembly, the disaggregation of a protein complex into its constituent components." [GOC:jl]


id: GO:0043245
name: extraorganismal space
namespace: cellular_component
def:
  "The environmental space outside of an organism; this may be a host organism in the case of parasitic and symbiotic organisms." [GOC:jl]


id: GO:0043246
name: megasome
namespace: cellular_component
def:
  "Large, cysteine proteinase rich lysosomes, often found in the amastigote (an intracytoplasmic, nonflagellated form of the parasite) stage of Leishmania species belonging to the mexicana complex." [PMID:11206117, PMID:1999020]


id: GO:0043247
name: telomere maintenance in response to DNA damage
namespace: biological_process
def:
  "Any process that occur in response to the presence of critically short or damaged telomeres." [GOC:BHF, GOC:BHF_telomere, GOC:jbu, PMID:15279784]


id: GO:0043248
name: proteasome assembly
namespace: biological_process
def:
  "The aggregation, arrangement and bonding together of a mature, active proteasome complex." [GOC:go_curators, PMID:10872471]


id: GO:0043249
name: erythrocyte maturation
namespace: biological_process
def:
  "A developmental process, independent of morphogenetic (shape) change, that is required for an erythrocyte to attain its fully functional state." [GOC:devbiol, GOC:jl]


id: GO:0043250
name: sodium-dependent organic anion transmembrane transporter activity
namespace: molecular_function
def:
  "Catalysis of the transfer of organic anions from one side of a membrane to the other, in a sodium dependent manner." [GOC:go_curators]


id: GO:0043251
name: sodium-dependent organic anion transport
namespace: biological_process
def:
  "The directed, sodium-dependent, movement of organic anions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:go_curators]


id: GO:0043252
name: sodium-independent organic anion transport
namespace: biological_process
def:
  "The directed, sodium-independent, movement of organic anions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:go_curators]


id: GO:0043255
name: regulation of carbohydrate biosynthetic process
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of carbohydrates." [GOC:jl]


id: GO:0043256
name: laminin complex
namespace: cellular_component
def:
  "A large, extracellular glycoprotein complex composed of three different polypeptide chains, alpha, beta and gamma. Provides an integral part of the structural scaffolding of basement membranes." [GOC:jl, http://www.sdbonline.org/fly/newgene/laminna1.htm, PMID:10842354]


id: GO:0043257
name: laminin-8 complex
namespace: cellular_component
def:
  "A laminin complex composed of alpha4, beta1 and gamma1 polypeptide chains." [GOC:jl, PMID:10842354]


id: GO:0043258
name: laminin-9 complex
namespace: cellular_component
def:
  "A laminin complex composed of alpha4, beta2 and gamma1 polypeptide chains." [GOC:jl, PMID:10842354]


id: GO:0043259
name: laminin-10 complex
namespace: cellular_component
def:
  "A laminin complex composed of alpha5, beta1 and gamma1 polypeptide chains." [GOC:jl, PMID:10842354]


id: GO:0043260
name: laminin-11 complex
namespace: cellular_component
def:
  "A laminin complex composed of alpha5, beta2 and gamma1 polypeptide chains." [GOC:jl, PMID:10842354]


id: GO:0043261
name: laminin-12 complex
namespace: cellular_component
def:
  "A laminin complex composed of alpha2, beta1 and gamma3 polypeptide chains." [GOC:jl, PMID:10842354]


id: GO:0043263
name: cellulosome
namespace: cellular_component
def:
  "An extracellular multi-enzyme complex containing up to 11 different enzymes aligned on a non-catalytic scaffolding glycoprotein. Functions to hydrolyze cellulose." [GOC:jl, PMID:11601609]


id: GO:0043264
name: extracellular non-membrane-bounded organelle
namespace: cellular_component
def:
  "Organized structure of distinctive morphology and function, not bounded by a lipid bilayer membrane and occurring outside the cell." [GOC:jl]


id: GO:0043265
name: ectoplasm
namespace: cellular_component
def:
  "Granule free cytoplasm, lying immediately below the plasma membrane." [GOC:curators, PMID:12211103]


id: GO:0043266
name: regulation of potassium ion transport
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of the directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl]


id: GO:0043267
name: negative regulation of potassium ion transport
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl]


id: GO:0043268
name: positive regulation of potassium ion transport
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of the directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl]


id: GO:0043269
name: regulation of ion transport
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of the directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl]


id: GO:0043270
name: positive regulation of ion transport
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of the directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl]


id: GO:0043271
name: negative regulation of ion transport
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl]


id: GO:0043272
name: ethylene biosynthesis involved in jasmonic acid and ethylene-dependent systemic resistance
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of ethylene (C2-H4, ethene), occurring as part of the process of jasmonic acid and ethylene-dependent systemic resistance." [GOC:jl]


id: GO:0043273
name: CTPase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: CTP + H2O = CDP + phosphate. May or may not be coupled to another reaction." [GOC:go_curators]


id: GO:0043274
name: phospholipase binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with any phospholipase, enzymes that catalyze of the hydrolysis of a glycerophospholipid." [GOC:jl]


id: GO:0043275
name: obsolete glutamate carboxypeptidase II activity
namespace: molecular_function
def:
  "OBSOLETE. Catalysis of the reaction: N-acetyl-L-Asp-L-Glu + H2O = N-acetyl-L-Asp + L-Glu." [BRENDA:3.4.17.21, GOC:jl]


id: GO:0043276
name: anoikis
namespace: biological_process
def:
  "Apoptosis triggered by inadequate or inappropriate adherence to substrate e.g. after disruption of the interactions between normal epithelial cells and the extracellular matrix." [GOC:jl, http://www.copewithcytokines.de/]


id: GO:0043277
name: apoptotic cell clearance
namespace: biological_process
def:
  "The recognition and removal of an apoptotic cell by a neighboring cell or by a phagocyte." [GOC:rk, PMID:14685684]


id: GO:0043278
name: response to morphine
namespace: biological_process
def:
  "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a morphine stimulus. Morphine is an opioid alkaloid, isolated from opium, with a complex ring structure." [CHEBI:17303, GOC:ef, GOC:jl]


id: GO:0043279
name: response to alkaloid
namespace: biological_process
def:
  "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an alkaloid stimulus. Alkaloids are a large group of nitrogenous substances found in naturally in plants, many of which have extracts that are pharmacologically active." [CHEBI:22315, GOC:jl]


id: GO:0043280
name: positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
namespace: biological_process
def:
  "Any process that activates or increases the activity of a cysteine-type endopeptidase involved in the apoptotic process." [GOC:jl, GOC:mtg_apoptosis]


id: GO:0043281
name: regulation of cysteine-type endopeptidase activity involved in apoptotic process
namespace: biological_process
def:
  "Any process that modulates the activity of a cysteine-type endopeptidase involved in apoptosis." [GOC:jl, GOC:mtg_apoptosis]


id: GO:0043282
name: pharyngeal muscle development
namespace: biological_process
def:
  "The process whose specific outcome is the progression of the pharyngeal muscle over time, from its formation to the mature structure. A pharyngeal muscle is any muscle that forms part of the pharynx." [GOC:go_curators]


id: GO:0043286
name: regulation of poly(3-hydroxyalkanoate) biosynthetic process
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of poly(3-hydroxyalkanoates), polyesters of 3-hydroxyacids produced as intracellular granules by a large variety of bacteria." [GOC:jl]


id: GO:0043287
name: poly(3-hydroxyalkanoate) binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with poly(3-hydroxyalkanoate)s, polyesters of 3-hydroxyacids produced as intracellular granules by a large variety of bacteria." [GOC:jl]


id: GO:0043288
name: apocarotenoid metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving apocarotenoids, a class of compounds derived from the oxidative cleavage of carotenoids, many of which are biologically important e.g. retinal and abscisic acid." [GOC:jl, http://www.msu.edu/~schwart1/apocarotenoids.htm]


id: GO:0043289
name: apocarotenoid biosynthetic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of apocarotenoids by the oxidative cleavage of carotenoids. Many apocarotenoids are biologically important e.g. retinal and abscisic acid." [GOC:jl, http://www.msu.edu/~schwart1/apocarotenoids.htm]


id: GO:0043290
name: apocarotenoid catabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the breakdown of apocarotenoids, a class of compounds derived from the oxidative cleavage of carotenoids, many of which are biologically important e.g. retinal and abscisic acid." [GOC:jl, http://www.msu.edu/~schwart1/apocarotenoids.htm]


id: GO:0043291
name: RAVE complex
namespace: cellular_component
def:
  "A multisubunit complex that in Saccharomyces is composed of three subunits, Rav1p, Rav2p and Skp1p. Acts transiently to catalyze assembly of cytoplasmic V1, with membrane embedded V0 to form the V-ATPase holoenzyme." [PMID:11283612, PMID:11844802]


id: GO:0043292
name: contractile fiber
namespace: cellular_component
def:
  "Fibers, composed of actin, myosin, and associated proteins, found in cells of smooth or striated muscle." [GOC:go_curators, ISBN:0815316194]


id: GO:0043293
name: apoptosome
namespace: cellular_component
def:
  "A multisubunit protein complex involved in the signaling phase of the apoptotic process. In mammals it is typically composed of seven Apaf-1 subunits bound to cytochrome c and caspase-9. A similar complex to promote apoptosis is formed from homologous gene products in other eukaryotic organisms." [GOC:mtg_apoptosis, PMID:10428850, PMID:11406413, PMID:12176339, PMID:15189137]


id: GO:0043294
name: mitochondrial glutamate synthase complex (NADH)
namespace: cellular_component
def:
  "A protein complex, found in the mitochondria, that in yeast consists of a large and a small subunit. Possesses glutamate synthase (NADH) activity." [GOC:jl, PMID:7047525]


id: GO:0043295
name: glutathione binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with glutathione; a tripeptide composed of the three amino acids cysteine, glutamic acid and glycine." [GOC:bf, ISBN:0198506732]


id: GO:0043296
name: apical junction complex
namespace: cellular_component
def:
  "A functional unit located near the cell apex at the points of contact between epithelial cells, which in vertebrates is composed of the tight junction, the zonula adherens, and desmosomes and in some invertebrates, such as Drosophila, is composed of the subapical complex (SAC), the zonula adherens and the septate junction. Functions in the regulation of cell polarity, tissue integrity and intercellular adhesion and permeability." [GOC:go_curators, GOC:kmv, PMID:12525486, PMID:15196556]


id: GO:0043297
name: apical junction assembly
namespace: biological_process
def:
  "The formation of an apical junction, a functional unit located near the cell apex at the points of contact between epithelial cells composed of the tight junction, the zonula adherens junction and the desmosomes, by the aggregation, arrangement and bonding together of its constituents." [GOC:go_curators, PMID:10854689, PMID:14729475, PMID:15196556]


id: GO:0043299
name: leukocyte degranulation
namespace: biological_process
def:
  "The regulated exocytosis of secretory granules by a leukocyte." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:0781735149]


id: GO:0043300
name: regulation of leukocyte degranulation
namespace: biological_process
def:
  "Any process that modulates the frequency, rate, or extent of leukocyte degranulation." [GOC:add, ISBN:0781735149]


id: GO:0043301
name: negative regulation of leukocyte degranulation
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the rate of leukocyte degranulation." [GOC:add, ISBN:0781735149]


id: GO:0043302
name: positive regulation of leukocyte degranulation
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of leukocyte degranulation." [GOC:add, ISBN:0781735149]


id: GO:0043303
name: mast cell degranulation
namespace: biological_process
def:
  "The regulated exocytosis of secretory granules containing preformed mediators such as histamine, serotonin, and neutral proteases by a mast cell." [ISBN:0781735149]


id: GO:0043304
name: regulation of mast cell degranulation
namespace: biological_process
def:
  "Any process that modulates the frequency, rate, or extent of mast cell degranulation." [ISBN:0781735149]


id: GO:0043305
name: negative regulation of mast cell degranulation
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the rate of mast cell degranulation." [ISBN:0781735149]


id: GO:0043306
name: positive regulation of mast cell degranulation
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of mast cell degranulation." [ISBN:0781735149]


id: GO:0043307
name: eosinophil activation
namespace: biological_process
def:
  "The change in morphology and behavior of a eosinophil resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor." [GOC:add, ISBN:0781735149]


id: GO:0043308
name: eosinophil degranulation
namespace: biological_process
def:
  "The regulated exocytosis of secretory granules containing preformed mediators such as major basic protein, eosinophil peroxidase, and eosinophil cationic protein by an eosinophil." [ISBN:0781735149]


id: GO:0043309
name: regulation of eosinophil degranulation
namespace: biological_process
def:
  "Any process that modulates the frequency, rate, or extent of eosinophil degranulation." [ISBN:0781735149]


id: GO:0043310
name: negative regulation of eosinophil degranulation
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the rate of eosinophil degranulation." [ISBN:0781735149]


id: GO:0043311
name: positive regulation of eosinophil degranulation
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of eosinophil degranulation." [ISBN:0781735149]


id: GO:0043312
name: neutrophil degranulation
namespace: biological_process
def:
  "The regulated exocytosis of secretory granules containing preformed mediators such as proteases, lipases, and inflammatory mediators by a neutrophil." [ISBN:0781735149]


id: GO:0043313
name: regulation of neutrophil degranulation
namespace: biological_process
def:
  "Any process that modulates the frequency, rate, or extent of neutrophil degranulation." [ISBN:0781735149]


id: GO:0043314
name: negative regulation of neutrophil degranulation
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the rate of neutrophil degranulation." [ISBN:0781735149]


id: GO:0043315
name: positive regulation of neutrophil degranulation
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of neutrophil degranulation." [ISBN:0781735149]


id: GO:0043316
name: cytotoxic T cell degranulation
namespace: biological_process
def:
  "The regulated exocytosis of secretory granules containing preformed mediators such as perforin and granzymes by a cytotoxic T cell." [ISBN:0781735149]


id: GO:0043317
name: regulation of cytotoxic T cell degranulation
namespace: biological_process
def:
  "Any process that modulates the frequency, rate, or extent of cytotoxic T cell degranulation." [ISBN:0781735149]


id: GO:0043318
name: negative regulation of cytotoxic T cell degranulation
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the rate of cytotoxic T cell degranulation." [ISBN:0781735149]


id: GO:0043319
name: positive regulation of cytotoxic T cell degranulation
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of cytotoxic T cell degranulation." [ISBN:0781735149]


id: GO:0043320
name: natural killer cell degranulation
namespace: biological_process
def:
  "The regulated exocytosis of secretory granules containing preformed mediators such as perforin and granzymes by a natural killer cell." [ISBN:0781735149]


id: GO:0043321
name: regulation of natural killer cell degranulation
namespace: biological_process
def:
  "Any process that modulates the frequency, rate, or extent of natural killer cell degranulation." [ISBN:0781735149]


id: GO:0043322
name: negative regulation of natural killer cell degranulation
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the rate of natural killer cell degranulation." [ISBN:0781735149]


id: GO:0043323
name: positive regulation of natural killer cell degranulation
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of natural killer cell degranulation." [ISBN:0781735149]


id: GO:0043324
name: pigment metabolic process involved in developmental pigmentation
namespace: biological_process
def:
  "The chemical reactions and pathways involving biological pigments e.g. melanin, occurring as part of the development of an organ or organism." [GOC:jl, ISBN:0198506732]


id: GO:0043325
name: phosphatidylinositol-3,4-bisphosphate binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with phosphatidylinositol-3,4-bisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 3' and 4' positions." [GOC:bf, GOC:go_curators]


id: GO:0043326
name: chemotaxis to folate
namespace: biological_process
def:
  "The directed movement of a motile cell or organism in response to the presence of folate." [GOC:go_curators]


id: GO:0043327
name: chemotaxis to cAMP
namespace: biological_process
def:
  "The directed movement of a motile cell or organism in response to the presence of 3',5'-cAMP." [GOC:go_curators]


id: GO:0043328
namespace: biological_process
name:
  protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway

def:
  "The process of directing proteins towards the vacuole using signals contained within the protein, occurring that contributes to protein catabolism via the multivesicular body (MVB) pathway." [GOC:jl, PMID:11511343]


id: GO:0043329
namespace: biological_process
name:
  protein targeting to membrane involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway

def:
  "The process of directing proteins towards a membrane using signals contained within the protein, occurring that contributes to ubiquitin-dependent protein catabolism via the MVB pathway; the destruction of a protein or peptide covalently tagged with a ubiquitin, via the multivesicular body (MVB) sorting pathway." [GOC:jl]


id: GO:0043330
name: response to exogenous dsRNA
namespace: biological_process
def:
  "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an exogenous double-stranded RNA stimulus." [GOC:go_curators]


id: GO:0043331
name: response to dsRNA
namespace: biological_process
def:
  "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a double-stranded RNA stimulus." [GOC:jl]


id: GO:0043332
name: mating projection tip
namespace: cellular_component
def:
  "The apex of the mating projection in unicellular fungi exposed to mating pheromone; site of polarized growth." [GOC:mcc]


id: GO:0043333
name: 2-octaprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 2-octaprenyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-methionine = 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-homocysteine." [GOC:kd, PMID:9045837]


id: GO:0043334
name: 2-hexaprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 2-hexaprenyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-methionine = 2-hexaprenyl-3-methyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-homocysteine." [GOC:kd, PMID:9083048]


id: GO:0043335
name: protein unfolding
namespace: biological_process
def:
  "The process of assisting in the disassembly of non-covalent linkages in a protein or protein aggregate, often where the proteins are in a non-functional or denatured state." [GOC:mlg]


id: GO:0043336
name: site-specific telomere resolvase activity
namespace: molecular_function
def:
  "Catalysis of a site-specific breakage and reunion reaction that generates two hairpin telomeres from a replicated telomere substrate. Occurs via a two-step transesterification with a protein-DNA intermediate similar to that used by topoisomerases and site-specific recombinases." [GOC:jl, PMID:11804598]


id: GO:0043337
name: CDP-diacylglycerol-phosphatidylglycerol phosphatidyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: CDP-diacylglycerol + phosphatidylglycerol = CMP + diphosphatidylglycerol." [GOC:jl]


id: GO:0043338
name: CTP:2,3-di-O-geranylgeranyl-sn-glycero-1-phosphate cytidyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: CTP + 2,3-di-O-geranylgeranyl-sn-glycero-1-phosphate = CDP-2,3-di-O-geranylgeranyl-sn-glycerol." [GOC:jl, PMID:10960477]


id: GO:0043353
name: enucleate erythrocyte differentiation
namespace: biological_process
def:
  "The process in which a myeloid precursor cell acquires specialized features of an erythrocyte without a nucleus. An example of this process is found in Mus musculus." [GOC:go_curators]


id: GO:0043354
name: enucleate erythrocyte maturation
namespace: biological_process
def:
  "A developmental process, independent of morphogenetic (shape) change, that is required for an enucleate erythrocyte to attain its fully functional state. An enucleate erythrocyte is an erythrocyte without a nucleus." [GOC:go_curators]


id: GO:0043362
name: nucleate erythrocyte maturation
namespace: biological_process
def:
  "A developmental process, independent of morphogenetic (shape) change, that is required for a nucleate erythrocyte to attain its fully functional state. A nucleate erythrocyte is an erythrocyte with a nucleus." [GOC:devbiol, GOC:jl]


id: GO:0043363
name: nucleate erythrocyte differentiation
namespace: biological_process
def:
  "The process in which a myeloid precursor cell acquires specializes features of an erythrocyte with a nucleus, as found in non-mammalian vertebrates such as birds." [GOC:jl]


id: GO:0043364
name: catalysis of free radical formation
namespace: molecular_function
def:
  "Catalysis of a reaction that generates a free radical, a highly reactive molecule with an unsatisfied electron valence pair." [GOC:jl]


id: GO:0043365
name: [formate-C-acetyltransferase]-activating enzyme activity
namespace: molecular_function
def:
  "Catalysis of the reaction: S-adenosyl-L-methionine + dihydroflavodoxin + [formate C-acetyltransferase]-glycine = 5'-deoxyadenosine + L-methionine + flavodoxin semiquinone + [formate C-acetyltransferase]-glycin-2-yl radical." [EC:1.97.1.4, GOC:jl, PMID:18307109]


id: GO:0043366
name: beta selection
namespace: biological_process
def:
  "The process in which successful recombination of a T cell receptor beta chain into a translatable protein coding sequence leads to rescue from apoptosis and subsequent proliferation of an immature T cell." [ISBN:0781735149, PMID:12220932]


id: GO:0043367
name: CD4-positive, alpha-beta T cell differentiation
namespace: biological_process
def:
  "The process in which a relatively unspecialized T cell acquires specialized features of a mature CD4-positive, alpha-beta T cell." [CL:0000624, ISBN:0781735149]


id: GO:0043368
name: positive T cell selection
namespace: biological_process
def:
  "The process of sparing immature T cells which react with self-MHC protein complexes with low affinity levels from apoptotic death." [ISBN:0781735149, PMID:12414722]


id: GO:0043369
name: CD4-positive or CD8-positive, alpha-beta T cell lineage commitment
namespace: biological_process
def:
  "The process in which an immature T cell commits to CD4-positive T cell lineage or the CD8-positive lineage of alpha-beta T cells." [ISBN:0781735149]


id: GO:0043370
name: regulation of CD4-positive, alpha-beta T cell differentiation
namespace: biological_process
def:
  "Any process that modulates the frequency, rate, or extent of CD4-positive, alpha-beta T cell differentiation." [GOC:add, GOC:pr, ISBN:0781735149]


id: GO:0043371
name: negative regulation of CD4-positive, alpha-beta T cell differentiation
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate, or extent of CD4-positive, alpha-beta T cell differentiation." [GOC:add, GOC:pr, ISBN:0781735149]


id: GO:0043372
name: positive regulation of CD4-positive, alpha-beta T cell differentiation
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of CD4-positive, alpha-beta T cell differentiation." [GOC:add, GOC:pr, ISBN:0781735149]


id: GO:0043373
name: CD4-positive, alpha-beta T cell lineage commitment
namespace: biological_process
def:
  "The process in which an immature T cell becomes committed to becoming a CD4-positive, alpha-beta T cell." [ISBN:0781735149]


id: GO:0043374
name: CD8-positive, alpha-beta T cell differentiation
namespace: biological_process
def:
  "The process in which a relatively unspecialized T cell acquires specialized features of a mature CD8-positive, alpha-beta T cell." [ISBN:0781735149]


id: GO:0043375
name: CD8-positive, alpha-beta T cell lineage commitment
namespace: biological_process
def:
  "The process in which an immature T cell becomes committed to becoming a CD8-positive, alpha-beta T cell." [ISBN:0781735149]


id: GO:0043376
name: regulation of CD8-positive, alpha-beta T cell differentiation
namespace: biological_process
def:
  "Any process that modulates the frequency, rate, or extent of CD8-positive, alpha-beta T cell differentiation." [GOC:add, ISBN:0781735149]


id: GO:0043377
name: negative regulation of CD8-positive, alpha-beta T cell differentiation
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the rate of CD8-positive, alpha-beta T cell differentiation." [GOC:add, ISBN:0781735149]


id: GO:0043378
name: positive regulation of CD8-positive, alpha-beta T cell differentiation
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of CD8-positive, alpha-beta T cell differentiation." [GOC:add, ISBN:0781735149]


id: GO:0043379
name: memory T cell differentiation
namespace: biological_process
def:
  "The process in which a newly activated T cell acquires specialized features of a memory T cell." [ISBN:0781735149]


id: GO:0043380
name: regulation of memory T cell differentiation
namespace: biological_process
def:
  "Any process that modulates the frequency, rate, or extent of memory T cell differentiation." [ISBN:0781735149]


id: GO:0043381
name: negative regulation of memory T cell differentiation
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the rate of memory T cell differentiation." [ISBN:0781735149]


id: GO:0043382
name: positive regulation of memory T cell differentiation
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of memory T cell differentiation." [ISBN:0781735149]


id: GO:0043383
name: negative T cell selection
namespace: biological_process
def:
  "The process of elimination of immature T cells which react strongly with self-antigens." [ISBN:0781735149, PMID:12414722]


id: GO:0043384
name: pre-T cell receptor complex
namespace: cellular_component
def:
  "A receptor complex found on immature T cells consisting of a T cell receptor beta chain and the pre-TCR-alpha chain, along with additional signaling components including CD3 family members and additional signaling proteins." [ISBN:0781735149, PMID:12220932]


id: GO:0043385
name: mycotoxin metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving a mycotoxin, any poisonous substance produced by a fungus." [CHEBI:25442, GOC:jl]


id: GO:0043386
name: mycotoxin biosynthetic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of a mycotoxin, any poisonous substance produced by a fungus." [CHEBI:25442, GOC:jl]


id: GO:0043387
name: mycotoxin catabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the breakdown of a mycotoxin, any poisonous substance produced by a fungus." [CHEBI:25442, GOC:jl]


id: GO:0043388
name: positive regulation of DNA binding
namespace: biological_process
def:
  "Any process that increases the frequency, rate or extent of DNA binding. DNA binding is any process in which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]


id: GO:0043390
name: aflatoxin B1 metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving aflatoxin B1, a potent hepatotoxic and hepatocarcinogenic mycotoxin produced by various species from the Aspergillus group of fungi." [CHEBI:2504, GOC:jl]


id: GO:0043391
name: aflatoxin B2 metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving aflatoxin B2, a mycotoxin produced by the fungal species Aspergillus flavus, Aspergillus parasiticus and Aspergillus nomius." [GOC:jl, http://www.aspergillus.man.ac.uk/]


id: GO:0043392
name: negative regulation of DNA binding
namespace: biological_process
def:
  "Any process that stops or reduces the frequency, rate or extent of DNA binding. DNA binding is any process in which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb]


id: GO:0043394
name: proteoglycan binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with a proteoglycan, any glycoprotein in which the carbohydrate units are glycosaminoglycans." [ISBN:0198506732]


id: GO:0043395
name: heparan sulfate proteoglycan binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with a heparan sulfate proteoglycan, any proteoglycan containing heparan sulfate as the glycosaminoglycan carbohydrate unit." [ISBN:0198506732]


id: GO:0043396
name: corticotropin-releasing hormone secretion
namespace: biological_process
def:
  "The regulated release of corticotropin-releasing hormone (CRH), a polypeptide hormone involved in the stress response. CRH is produced by the hypothalamus and stimulates corticotropic cells of the anterior lobe of the pituitary to produce corticotropic hormone (CTH) and other biologically active substances e.g. 2-endorphin, release of CRH is affected by serum levels of cortisol, by stress and by the sleep/wake cycle." [GOC:go_curators, PMID:11027914]


id: GO:0043397
name: regulation of corticotropin-releasing hormone secretion
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of corticotropin-releasing hormone secretion." [GOC:go_curators, PMID:11027914]


id: GO:0043398
name: HLH domain binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with Helix Loop Helix, a domain of 40-50 residues that occurs in specific DNA-binding proteins that act as transcription factors. The domain is formed of two amphipathic helices joined by a variable length linker region that can form a loop and it mediates protein dimerization." [GOC:go_curators, Prosite:PDOC0038]


id: GO:0043399
name: tRNA A64-2'-O-ribosylphosphate transferase activity
namespace: molecular_function
def:
  "Catalysis of the transfer of a phosphoribosyl group from 5'-phosphoribosyl-1'-pyrophosphate to position 64 of initiator tRNA." [GOC:jl, PMID:7954819]


id: GO:0043400
name: cortisol secretion
namespace: biological_process
def:
  "The regulated release of cortisol, a steroid hormone that in humans is the major circulating hormone of the cortex, or outer layer, of the adrenal gland." [CHEBI:17650, PMID:11027914]


id: GO:0043401
name: steroid hormone mediated signaling pathway
namespace: biological_process
def:
  "A series of molecular signals mediated by a steroid hormone binding to a receptor." [PMID:12606724]


id: GO:0043402
name: glucocorticoid mediated signaling pathway
namespace: biological_process
def:
  "A series of molecular signals mediated by the detection of a glucocorticoid hormone." [PMID:15240347]


id: GO:0043403
name: skeletal muscle tissue regeneration
namespace: biological_process
def:
  "The regrowth of skeletal muscle tissue to repair injured or damaged muscle fibers in the postnatal stage." [GOC:ef, GOC:mtg_muscle, PMID:12021255, PMID:16607119]


id: GO:0043404
name: corticotropin-releasing hormone receptor activity
namespace: molecular_function
def:
  "Combining with corticotropin-releasing hormone and transmitting the signal to initiate a change in cell activity." [GOC:signaling, ISBN:0838577016, PMID:11027914, PMID:15134857]


id: GO:0043405
name: regulation of MAP kinase activity
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of MAP kinase activity." [GOC:dph, GOC:go_curators]


id: GO:0043406
name: positive regulation of MAP kinase activity
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of MAP kinase activity." [GOC:dph, GOC:go_curators]


id: GO:0043407
name: negative regulation of MAP kinase activity
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of MAP kinase activity." [GOC:dph, GOC:go_curators]


id: GO:0043408
name: regulation of MAPK cascade
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of signal transduction mediated by the MAP kinase (MAPK) cascade." [GOC:go_curators]


id: GO:0043409
name: negative regulation of MAPK cascade
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the MAPKKK cascade." [GOC:go_curators]


id: GO:0043410
name: positive regulation of MAPK cascade
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the MAPK cascade." [GOC:go_curators]


id: GO:0043411
name: obsolete myopalladin binding
namespace: molecular_function
def:
  "OBSOLETE. Interacting selectively and non-covalently with myopalladin, a myofibrillar protein with titin-like Ig domains." [GOC:go_curators]


id: GO:0043412
name: macromolecule modification
namespace: biological_process
def:
  "The covalent alteration of one or more monomeric units in a polypeptide, polynucleotide, polysaccharide, or other biological macromolecule, resulting in a change in its properties." [GOC:go_curators]


id: GO:0043413
name: macromolecule glycosylation
namespace: biological_process
def:
  "The covalent attachment of a glycosyl residue to one or more monomeric units in a polypeptide, polynucleotide, polysaccharide, or other biological macromolecule." [GOC:jl]


id: GO:0043414
name: macromolecule methylation
namespace: biological_process
def:
  "The covalent attachment of a methyl residue to one or more monomeric units in a polypeptide, polynucleotide, polysaccharide, or other biological macromolecule." [GOC:go_curators]


id: GO:0043417
name: negative regulation of skeletal muscle tissue regeneration
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of skeletal muscle regeneration." [GOC:jl]


id: GO:0043418
name: homocysteine catabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the breakdown of homocysteine, the amino acid alpha-amino-gamma-mercaptobutanoic acid." [GOC:jl]


id: GO:0043419
name: urea catabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the breakdown of urea, the water soluble compound O=C-(NH2)2." [GOC:jl]


id: GO:0043420
name: anthranilate metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving anthranilate (2-aminobenzoate)." [CHEBI:16567, GOC:jl]


id: GO:0043421
name: anthranilate catabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the breakdown of anthranilate (2-aminobenzoate)." [CHEBI:16567, GOC:jl]


id: GO:0043422
name: protein kinase B binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with protein kinase B, an intracellular kinase that is important in regulating glucose metabolism." [GOC:jl, http://www.heartandmetabolism.org/]


id: GO:0043423
name: 3-phosphoinositide-dependent protein kinase binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with a 3-phosphoinositide-dependent protein kinase." [GOC:jl]


id: GO:0043425
name: bHLH transcription factor binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with any of the basic Helix-Loop-Helix (bHLH) superfamily of transcription factors, important regulatory components in transcriptional networks of many developmental pathways." [PMID:9144210]


id: GO:0043426
name: MRF binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with Myogenic Regulatory Factor (MRF), a member of the basic Helix-Loop-Helix (bHLH) superfamily of transcription factors." [PMID:10966875]


id: GO:0043427
name: carbon fixation by 3-hydroxypropionate cycle
namespace: biological_process
def:
  "An autotrophic carbon dioxide fixation pathway by which two molecules of carbon dioxide are fixed to form glyoxylate. Acetyl coenzyme A (acetyl-CoA) is assumed to be converted to malate, and two CO2 molecules are thereby fixed. Malyl-CoA is thought to be cleaved to acetyl-CoA, the starting molecule, and glyoxylate, the carbon fixation product." [GOC:jl, PMID:11418572, PMID:15838028]


id: GO:0043428
name: 2-heptaprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 2-heptaprenyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-methionine = 2-heptaprenyl-3-methyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-homocysteine." [GOC:jl, PMID:11583838]


id: GO:0043429
name: 2-nonaprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 2-nonaprenyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-methionine = 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-homocysteine." [GOC:jl, PMID:11583838]


id: GO:0043430
name: 2-decaprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 2-decaprenyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-methionine = 2-decaprenyl-3-methyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-homocysteine." [GOC:jl, PMID:11583838]


id: GO:0043431
name: 2-octaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinone methyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 2-octaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinol + S-adenosyl-L-methionine = ubiquinol + S-adenosyl-L-homocysteine." [GOC:jl, PMID:11583838, PMID:1479344]


id: GO:0043433
name: negative regulation of sequence-specific DNA binding transcription factor activity
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of a transcription factor, any factor involved in the initiation or regulation of transcription." [GOC:jl]


id: GO:0043434
name: response to peptide hormone
namespace: biological_process
def:
  "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide hormone stimulus. A peptide hormone is any of a class of peptides that are secreted into the blood stream and have endocrine functions in living animals." [PMID:11027914, PMID:15134857, Wikipedia:Peptide_hormone]


id: GO:0043435
name: response to corticotropin-releasing hormone
namespace: biological_process
def:
  "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a corticotropin-releasing hormone stimulus. Corticotropin-releasing hormone is a peptide hormone involved in the stress response." [PMID:11027914, PMID:15134857, Wikipedia:Corticotropin-releasing_hormone]


id: GO:0043436
name: oxoacid metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving any oxoacid; an oxoacid is a compound which contains oxygen, at least one other element, and at least one hydrogen bound to oxygen, and which produces a conjugate base by loss of positive hydrogen ion(s) (hydrons)." [CHEBI:24833]


id: GO:0043438
name: acetoacetic acid metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving acetoacetic acid, 3-oxobutanoic acid; the empirical formula is C4H6O3 or CH3COCH2COOH." [CHEBI:15344, Wikipedia:Acetoacetic_acid]


id: GO:0043441
name: acetoacetic acid biosynthetic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of acetoacetic acid, a beta-keto acid of the keto acid group, empirical formula is C4H6O3 or CH3COCH2COOH." [GOC:jl]


id: GO:0043442
name: acetoacetic acid catabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the breakdown of acetoacetic acid, a beta-keto acid of the keto acid group, empirical formula is C4H6O3 or CH3COCH2COOH." [GOC:jl]


id: GO:0043446
name: cellular alkane metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving an alkane, any acyclic branched or unbranched hydrocarbon having the general formula CnH2n+2, as carried out by individual cells." [CHEBI:18310, GOC:jl, Wikipedia:Alkane]


id: GO:0043447
name: alkane biosynthetic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of an alkane, any acyclic branched or unbranched hydrocarbon having the general formula CnH2n+2." [CHEBI:18310, GOC:jl, Wikipedia:Alkane]


id: GO:0043448
name: alkane catabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the breakdown of an alkane, any acyclic branched or unbranched hydrocarbon having the general formula CnH2n+2." [CHEBI:18310, GOC:jl, Wikipedia:Alkane]


id: GO:0043449
name: cellular alkene metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving an alkene, any acyclic branched or unbranched hydrocarbon having one carbon-carbon double bond and the general formula CnH2n, as carried out by individual cells." [CHEBI:32878, GOC:jl, Wikipedia:Alkene]


id: GO:0043450
name: alkene biosynthetic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of an alkene, any acyclic branched or unbranched hydrocarbon having one carbon-carbon double bond and the general formula CnH2n." [CHEBI:32878, GOC:jl, Wikipedia:Alkene]


id: GO:0043451
name: alkene catabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the breakdown of an alkene, any acyclic branched or unbranched hydrocarbon having one carbon-carbon double bond and the general formula CnH2n." [CHEBI:32878, GOC:jl, Wikipedia:Alkene]


id: GO:0043452
name: cellular alkyne metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving an alkyne, any cyclic branched or unbranched hydrocarbon having a carbon-carbon triple bond and the general formula CnH2n-2, as carried out by individual cells." [CHEBI:22339, GOC:jl, Wikipedia:Alkyne]


id: GO:0043453
name: alkyne biosynthetic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of an alkyne, any cyclic branched or unbranched hydrocarbon having a carbon-carbon triple bond and the general formula CnH2n-2." [CHEBI:22339, GOC:jl, Wikipedia:Alkyne]


id: GO:0043454
name: alkyne catabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the breakdown of an alkyne, any cyclic branched or unbranched hydrocarbons having a carbon-carbon triple bond and the general formula CnH2n-2." [CHEBI:22339, GOC:jl, Wikipedia:Alkyne]


id: GO:0043455
name: regulation of secondary metabolic process
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of secondary metabolism, the chemical reactions and pathways involving compounds that are not necessarily required for growth and maintenance of cells, and are often unique to a taxon." [GOC:jl]


id: GO:0043456
name: regulation of pentose-phosphate shunt
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of the pentose-phosphate shunt, the process in which glucose is oxidized, coupled to NADPH synthesis." [GOC:jl]


id: GO:0043457
name: regulation of cellular respiration
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of cellular respiration, the enzymatic release of energy from organic compounds." [GOC:jl]


id: GO:0043458
name: ethanol biosynthetic process involved in glucose fermentation to ethanol
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of ethanol, CH3-CH2-OH, as part of the process of glucose catabolism to ethanol, CO2 and ATP." [GOC:dph, GOC:jl, GOC:tb]


id: GO:0043459
name: obsolete response to short exposure to lithium ion
namespace: biological_process
def:
  "OBSOLETE. A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a single or short exposure to a lithium ion stimulus." [PMID:10208444]


id: GO:0043460
name: obsolete response to long exposure to lithium ion
namespace: biological_process
def:
  "OBSOLETE. A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a long or persistent exposure to a lithium ion stimulus." [PMID:10208444]


id: GO:0043461
name: proton-transporting ATP synthase complex assembly
namespace: biological_process
def:
  "The aggregation, arrangement and bonding together of a proton-transporting ATP synthase (also known as F-type ATPase), a two-sector ATPase found in the inner membrane of mitochondria and chloroplasts, and in bacterial plasma membranes." [GOC:jl, GOC:mah, http://www.mblab.gla.ac.uk/]


id: GO:0043463
name: regulation of rhamnose catabolic process
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of rhamnose, the hexose 6-deoxy-L-mannose." [GOC:jl]


id: GO:0043464
name: malolactic fermentation
namespace: biological_process
def:
  "The anaerobic enzymatic conversion of L-malate to L-lactate and carbon dioxide, yielding energy in the form of ATP." [PMID:10427020, PMID:8808948]


id: GO:0043465
name: regulation of fermentation
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of fermentation, the anaerobic enzymatic conversion of organic compounds, especially carbohydrates, to other compounds, especially to ethyl alcohol, resulting in energy in the form of adenosine triphosphate (ATP)." [GOC:jl]


id: GO:0043466
name: pyrimidine nucleobase fermentation
namespace: biological_process
def:
  "The anaerobic conversion of pyrimidine nucleobases, yielding energy in the form of ATP." [CHEBI:26432, GOC:jl]


id: GO:0043467
name: regulation of generation of precursor metabolites and energy
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of precursor metabolites, substances from which energy is derived, and the processes involved in the liberation of energy from these substances." [GOC:jl]


id: GO:0043468
name: regulation of fucose catabolic process
namespace: biological_process
def:
  "Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of fucose." [GOC:mlg]


id: GO:0043469
name: regulation of D-xylose catabolic process
namespace: biological_process
def:
  "Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of xylose." [GOC:mlg]


id: GO:0043470
name: regulation of carbohydrate catabolic process
namespace: biological_process
def:
  "Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of carbohydrates." [GOC:mlg]


id: GO:0043471
name: regulation of cellular carbohydrate catabolic process
namespace: biological_process
def:
  "Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of carbohydrates, carried out by individual cells." [GOC:jl]


id: GO:0043473
name: pigmentation
namespace: biological_process
def:
  "The accumulation of pigment in an organism, tissue or cell, either by increased deposition or by increased number of cells." [GOC:jl]


id: GO:0043474
name: pigment metabolic process involved in pigmentation
namespace: biological_process
def:
  "The chemical reactions and pathways involving a pigment, any general or particular coloring matter in living organisms, resulting in the deposition or aggregation of pigment in an organism, tissue or cell." [GOC:dph, GOC:jl, GOC:tb]


id: GO:0043475
name: pigment metabolic process involved in pigment accumulation
namespace: biological_process
def:
  "The chemical reactions and pathways involving a pigment, any general or particular coloring matter in living organisms, as part of the accumulation of pigment." [GOC:jl]


id: GO:0043476
name: pigment accumulation
namespace: biological_process
def:
  "The aggregation of coloring matter in a particular location in an organism, tissue or cell, occurring in response to some external stimulus." [GOC:jl]


id: GO:0043477
name: pigment biosynthetic process involved in pigment accumulation
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of a pigment, any general or particular coloring matter in living organisms, resulting in pigment accumulation." [GOC:dph, GOC:jl, GOC:tb]


id: GO:0043478
name: pigment accumulation in response to UV light
namespace: biological_process
def:
  "The aggregation of coloring matter in a particular location in an organism, tissue or cell, occurring in response to a UV light stimulus." [GOC:jl]


id: GO:0043479
name: pigment accumulation in tissues in response to UV light
namespace: biological_process
def:
  "The aggregation of coloring matter in a particular location in a tissue, occurring in response to a UV light stimulus." [GOC:jl]


id: GO:0043480
name: pigment accumulation in tissues
namespace: biological_process
def:
  "The aggregation of coloring matter in a particular location in a tissue, occurring in response to an external stimulus." [GOC:jl]


id: GO:0043481
name: anthocyanin accumulation in tissues in response to UV light
namespace: biological_process
def:
  "The aggregation of the pigment anthocyanin in a particular location in a tissue, occurring in response to a UV light stimulus." [GOC:jl]


id: GO:0043482
name: cellular pigment accumulation
namespace: biological_process
def:
  "The aggregation of coloring matter in a particular location in a cell, occurring in response to some external stimulus." [GOC:jl]


id: GO:0043483
name: anthocyanin biosynthetic process involved in anthocyanin accumulation in response to UV light
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of the pigment anthocyanin, contributing to anthocyanin accumulation in a tissue in response to a UV light stimulus." [GOC:dph, GOC:jl, GOC:tb]


id: GO:0043484
name: regulation of RNA splicing
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of RNA splicing, the process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA." [GOC:jl]


id: GO:0043486
name: histone exchange
namespace: biological_process
def:
  "The replacement, within chromatin, of resident histones or histone subunits with alternative, sometimes variant, histones or subunits." [GOC:jl, PMID:11735001, PMID:15066277]


id: GO:0043487
name: regulation of RNA stability
namespace: biological_process
def:
  "Any process that modulates the propensity of RNA molecules to degradation. Includes processes that both stabilize and destabilize RNAs." [GOC:jl]


id: GO:0043488
name: regulation of mRNA stability
namespace: biological_process
def:
  "Any process that modulates the propensity of mRNA molecules to degradation. Includes processes that both stabilize and destabilize mRNAs." [GOC:jl]


id: GO:0043490
name: malate-aspartate shuttle
namespace: biological_process
def:
  "The process of transferring reducing equivalents from the cytosol into the mitochondria; NADH is used to synthesise malate in the cytosol; this compound is then transported into the mitochondria where it is converted to oxaloacetate using NADH, the oxaloacetate reacts with gluamate to form aspartate, and the aspartate then returns to the cytosol to complete the cycle." [GOC:jl, GOC:mtg_electron_transport, ISBN:0716743663]


id: GO:0043491
name: protein kinase B signaling
namespace: biological_process
def:
  "A series of reactions, mediated by the intracellular serine/threonine kinase protein kinase B (also called AKT), which occurs as a result of a single trigger reaction or compound." [GOC:bf, PMID:20517722]


id: GO:0043492
name: ATPase activity, coupled to movement of substances
namespace: molecular_function
def:
  "Catalysis of the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of a substance." [GOC:jl]


id: GO:0043493
name: viral terminase complex
namespace: cellular_component
def:
  "A complex of a large and small subunit which catalyze the packaging of DNA into viral heads. Note that not all viral terminases have this structure, some exist as single polypeptides." [GOC:bf, GOC:bm, GOC:jl, GOC:mlg]


id: GO:0043494
name: CLRC ubiquitin ligase complex
namespace: cellular_component
def:
  "An cullin-dependent E3 ubiquitin ligase/histone H3-K9 methyltransferase complex essential for heterochromatin assembly by RNAi." [GOC:vw, PMID:16127433, PMID:20211136]


id: GO:0043495
name: protein anchor
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with both a protein or protein complex and a membrane, in order to maintain the localization of the protein at a specific location on the membrane." [GOC:go_curators]


id: GO:0043496
name: regulation of protein homodimerization activity
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of protein homodimerization, interacting selectively with an identical protein to form a homodimer." [GOC:jl, GOC:tb]


id: GO:0043497
name: regulation of protein heterodimerization activity
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of protein heterodimerization, interacting selectively with a nonidentical protein to form a heterodimer." [GOC:jl, GOC:tb]


id: GO:0043498
name: obsolete cell surface binding
namespace: molecular_function
def:
  "OBSOLETE. Interacting selectively and non-covalently with any component on the surface of a cell." [GOC:jl]


id: GO:0043499
name: obsolete eukaryotic cell surface binding
namespace: molecular_function
def:
  "OBSOLETE. Interacting selectively and non-covalently with any component on the surface of a eukaryotic cell." [GOC:jl]


id: GO:0043500
name: muscle adaptation
namespace: biological_process
def:
  "A process in which muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors. These adaptive events occur in both muscle fibers and associated structures (motoneurons and capillaries), and they involve alterations in regulatory mechanisms, contractile properties and metabolic capacities." [GOC:mtg_muscle, PMID:11181628, PMID:11449884, PMID:12605307]


id: GO:0043501
name: skeletal muscle adaptation
namespace: biological_process
def:
  "Any process in which skeletal muscles change their phenotypic profiles in response to altered functional demands and a variety of signals." [GOC:mtg_muscle, PMID:11181628, PMID:11449884, PMID:12605307]


id: GO:0043502
name: regulation of muscle adaptation
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of muscle adaptation." [GOC:go_curators, GOC:mtg_muscle]


id: GO:0043503
name: skeletal muscle fiber adaptation
namespace: biological_process
def:
  "Any process in which the skeletal muscle fibers change their phenotypic profiles in response to altered functional demands and a variety of signals. Muscle fibers are formed by the maturation of myotubes. They can be classed as slow, intermediate/fast or fast." [GOC:mtg_muscle, PMID:11181628, PMID:11449884, PMID:12605307]


id: GO:0043504
name: mitochondrial DNA repair
namespace: biological_process
def:
  "The process of restoring mitochondrial DNA after damage." [PMID:12565799, PMID:15189144, PMID:16050976]


id: GO:0043505
name: CENP-A containing nucleosome
namespace: cellular_component
def:
  "A form of nucleosome located only at the centromere, in which the histone H3 is replaced by the variant form CENP-A (sometimes known as CenH3)." [GOC:go_curators, PMID:15175412, PMID:16183641]


id: GO:0043507
name: positive regulation of JUN kinase activity
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of JUN kinase activity." [GOC:jl]


id: GO:0043508
name: negative regulation of JUN kinase activity
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of JUN kinase activity." [GOC:jl]


id: GO:0043509
name: activin A complex
namespace: cellular_component
def:
  "A nonsteroidal regulator, composed of two covalently linked inhibin beta-A subunits (sometimes known as activin beta-A or activin/inhibin beta-A)." [GOC:go_curators]


id: GO:0043510
name: activin B complex
namespace: cellular_component
def:
  "A nonsteroidal regulator, composed of two covalently linked inhibin beta-B subunits (sometimes known as activin beta-B or activin/inhibin beta-B)." [GOC:go_curators]


id: GO:0043511
name: inhibin complex
namespace: cellular_component
def:
  "Heterodimeric hormone composed of an inhibin alpha subunit complexed with either an inhibin beta-A subunit, to form inhibin A, or an inhibin beta-B subunit, to form inhibin B." [GOC:jl]


id: GO:0043512
name: inhibin A complex
namespace: cellular_component
def:
  "Heterodimeric hormone composed of an inhibin alpha subunit complexed with an inhibin beta-A subunit." [GOC:jl]


id: GO:0043513
name: inhibin B complex
namespace: cellular_component
def:
  "Heterodimeric hormone composed of an inhibin alpha subunit complexed with an inhibin beta-B subunit." [GOC:jl]


id: GO:0043514
name: interleukin-12 complex
namespace: cellular_component
def:
  "A protein complex that is composed of an interleukin-12 alpha (p35, product of the IL12A gene) and an interleukin-12 beta subunit (p40, product of the IL12B gene) and is secreted into the extracellular space." [GOC:add, GOC:ebc, GOC:mah, PMID:12948519, PMID:1381512]


id: GO:0043515
name: kinetochore binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with a kinetochore, a proteinaceous structure on a condensed chromosome, beside the centromere, to which the spindle fibers are attached." [GOC:jl, http://www.mercksource.com/]


id: GO:0043516
name: regulation of DNA damage response, signal transduction by p53 class mediator
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of the cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage." [GOC:jl]


id: GO:0043517
name: positive regulation of DNA damage response, signal transduction by p53 class mediator
namespace: biological_process
def:
  "Any process that activates, maintains or increases the rate of the cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage." [GOC:jl]


id: GO:0043518
name: negative regulation of DNA damage response, signal transduction by p53 class mediator
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of the cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage." [GOC:jl]


id: GO:0043519
name: regulation of myosin II filament organization
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of the assembly, arrangement of constituent parts, or disassembly of a bipolar filament composed of myosin II molecules." [GOC:jl]


id: GO:0043520
name: regulation of myosin II filament assembly
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of the formation of a bipolar filament composed of myosin II molecules." [GOC:jl]


id: GO:0043521
name: regulation of myosin II filament disassembly
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of the disassembly of a bipolar filament composed of myosin II molecules." [GOC:jl]


id: GO:0043522
name: leucine zipper domain binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with a leucine zipper domain, a protein secondary structure exhibiting a periodic repetition of leucine residues at every seventh position over a distance covering eight helical turns." [GOC:jl, InterPro:IPR002158]


id: GO:0043523
name: regulation of neuron apoptotic process
namespace: biological_process
def:
  "Any process that modulates the occurrence or rate of cell death by apoptotic process in neurons." [GOC:go_curators, GOC:mtg_apoptosis]


id: GO:0043524
name: negative regulation of neuron apoptotic process
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process in neurons." [GOC:go_curators, GOC:mtg_apoptosis]


id: GO:0043525
name: positive regulation of neuron apoptotic process
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of cell death of neurons by apoptotic process." [GOC:go_curators, GOC:mtg_apoptosis]


id: GO:0043526
name: obsolete neuroprotection
namespace: biological_process
def:
  "OBSOLETE. Any process that modulates the occurrence or rate of cell death by apoptosis in the nervous system. It may stop or prevent or reduce the rate of cell death by apoptosis and it is activated by stress to counteract death signals in central nervous systems. Different neuroprotective mechanisms may be activated to combat distinct types of cellular stress, ERK pathway is one of several neuroprotective mechanisms and it is a model system to study neuronal apoptosis, which may contribute to several neurodegenerative diseases and aging-related neuron loss." [GOC:mtg_apoptosis, MSH:D017209, PMID:10208444, PMID:11909981, PMID:15905876]


id: GO:0043527
name: tRNA methyltransferase complex
namespace: cellular_component
def:
  "A multimeric protein complex involved in the methylation of specific nucleotides in tRNA." [GOC:jl]


id: GO:0043528
name: tRNA (m2G10) methyltransferase complex
namespace: cellular_component
def:
  "A protein complex required for the methylation of the guanosine nucleotide at position 10 (m2G10) in tRNA. In S. cerevisiae, this complex consists of at least two subunits, Trm11p and Trm112p." [PMID:15899842]


id: GO:0043529
name: GET complex
namespace: cellular_component
def:
  "A multisubunit complex involved in ER/Golgi trafficking (Golgi to ER Traffic). In yeast, includes Get1p, Get2p and Get3p proteins." [PMID:16269340]


id: GO:0043530
name: adenosine 5'-monophosphoramidase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: adenosine 5'-monophosphoramidate = AMP + NH2. Other substrates include AMP-morpholidate, AMP-N-alanine methyl ester and AMP-alpha-acetyl lysine methyl ester." [PMID:11805111]


id: GO:0043532
name: angiostatin binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with angiostatin, a proteolytic product of plasminogen or plasmin containing at least one intact kringle domain, and which is an inhibitor of angiogenesis." [PMID:16043488]


id: GO:0043533
name: inositol 1,3,4,5 tetrakisphosphate binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with inositol 1,3,4,5 tetrakisphosphate." [GOC:go_curators]


id: GO:0043534
name: blood vessel endothelial cell migration
namespace: biological_process
def:
  "The orderly movement of an endothelial cell into the extracellular matrix in order to form new blood vessels during angiogenesis." [PMID:11166264]


id: GO:0043535
name: regulation of blood vessel endothelial cell migration
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of the migration of the endothelial cells of blood vessels." [GOC:go_curators]


id: GO:0043536
name: positive regulation of blood vessel endothelial cell migration
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of the migration of the endothelial cells of blood vessels." [GOC:go_curators]


id: GO:0043537
name: negative regulation of blood vessel endothelial cell migration
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of the migration of the endothelial cells of blood vessels." [GOC:go_curators]


id: GO:0043538
name: regulation of actin phosphorylation
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of the transfer of one or more phosphate groups to an actin molecule." [GOC:go_curators]


id: GO:0043540
name: 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase complex
namespace: cellular_component
def:
  "A homodimeric, bifunctional enzyme complex which catalyzes the synthesis and degradation of fructose 2,6-bisphosphate, and is required for both glycolysis and gluconeogenesis." [GOC:jl, GOC:so]


id: GO:0043541
name: UDP-N-acetylglucosamine transferase complex
namespace: cellular_component
def:
  "A multienzyme, heterooligomeric complex involved in dolichyl-linked oligosaccharide synthesis. In yeast the complex is composed of Alg7p, which catalyzes the first step (GlcNAc1-PP-Dol from dolichol-phosphate and UDP-GlcNAc), and Alg13p plus Alg14p, the catalytic and anchoring subunits respectively, which together catalyze the second step (GlcNAc2-PP-dolichol from GlcNAc1-PP-Dol and UDP-GlcNAc) of dolichyl-linked oligosaccharide synthesis." [GOC:rn, PMID:19129246]


id: GO:0043542
name: endothelial cell migration
namespace: biological_process
def:
  "The orderly movement of an endothelial cell into the extracellular matrix to form an endothelium." [GOC:go_curators]


id: GO:0043543
name: protein acylation
namespace: biological_process
def:
  "The addition of an acyl group, any group or radical of the form RCO- where R is an organic group, to a protein amino acid." [GOC:jl]


id: GO:0043544
name: lipoamide binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with lipoamide, the functional form of lipoic acid in which the carboxyl group is attached to protein by an amide linkage to a lysine amino group." [GOC:go_curators]


id: GO:0043545
name: molybdopterin cofactor metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving the molybdopterin cofactor (Moco), essential for the catalytic activity of some enzymes, e.g. sulfite oxidase, xanthine dehydrogenase, and aldehyde oxidase. The cofactor consists of a mononuclear molybdenum (Mo-molybdopterin) or tungsten ion (W-molybdopterin) coordinated by one or two molybdopterin ligands." [ISSN:09498257]


id: GO:0043546
name: molybdopterin cofactor binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with the molybdopterin cofactor (Moco), essential for the catalytic activity of some enzymes, e.g. sulfite oxidase, xanthine dehydrogenase, and aldehyde oxidase. The cofactor consists of a mononuclear molybdenum (Mo-molybdopterin) or tungsten ion (W-molybdopterin) coordinated by one or two molybdopterin ligands." [ISSN:09498257]


id: GO:0043548
name: phosphatidylinositol 3-kinase binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with a phosphatidylinositol 3-kinase, any enzyme that catalyzes the addition of a phosphate group to an inositol lipid at the 3' position of the inositol ring." [PMID:10209156, PMID:9255069]


id: GO:0043549
name: regulation of kinase activity
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [GOC:bf]


id: GO:0043550
name: regulation of lipid kinase activity
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of lipid kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a simple or complex lipid." [GOC:bf]


id: GO:0043551
name: regulation of phosphatidylinositol 3-kinase activity
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of phosphatidylinositol 3-kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to an inositol lipid at the 3' position of the inositol ring." [GOC:bf]


id: GO:0043552
name: positive regulation of phosphatidylinositol 3-kinase activity
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of phosphatidylinositol 3-kinase activity." [GOC:bf]


id: GO:0043553
name: negative regulation of phosphatidylinositol 3-kinase activity
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of phosphatidylinositol 3-kinase activity." [GOC:bf]


id: GO:0043554
name: aerobic respiration, using arsenite as electron donor
namespace: biological_process
def:
  "The oxidation of arsenite to arsenate, using oxygen (O2) as the electron acceptor. Arsenite oxidase provides electrons to an electron carrier which transfers them to oxygen utilizing respiratory systems." [GOC:mlg]


id: GO:0043555
name: regulation of translation in response to stress
namespace: biological_process
def:
  "Modulation of the frequency, rate or extent of translation as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:jl]


id: GO:0043556
name: regulation of translation in response to oxidative stress
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of translation as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:jl]


id: GO:0043557
name: regulation of translation in response to osmotic stress
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of the frequency, rate or extent of translation as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell." [GOC:jl]


id: GO:0043558
name: regulation of translational initiation in response to stress
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of translation initiation, as a result of a stimulus indicating the organism is under stress." [GOC:jl]


id: GO:0043559
name: insulin binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with insulin, a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms." [ISBN:0198506732]


id: GO:0043560
name: insulin receptor substrate binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with any of the insulin receptor substrate (IRS) proteins, adaptor proteins that bind to the transphosphorylated insulin and insulin-like growth factor receptors, are themselves phosphorylated and in turn recruit SH2 domain-containing signaling molecules to form a productive signaling complex." [PMID:12829233]


id: GO:0043561
name: regulation of translational initiation in response to osmotic stress
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of translation initiation, as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell." [GOC:dph, GOC:jl, GOC:tb]


id: GO:0043562
name: cellular response to nitrogen levels
namespace: biological_process
def:
  "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of inorganic nitrogen." [GOC:jl]


id: GO:0043563
name: odorant transporter activity
namespace: molecular_function
def:
  "Enables the directed movement of odorants, any substance capable of stimulating the sense of smell, into, out of or within a cell, or between cells." [GOC:jl]


id: GO:0043564
name: Ku70:Ku80 complex
namespace: cellular_component
def:
  "Heterodimeric protein complex composed of a 70 kDa and a 80 kDa subunit, binds DNA through a channel formed by the heterodimer. Functions in DNA double stranded break repair, chromosome maintenance, transcription regulation, V(D)J recombination, and activation of DNA-PK." [PMID:12518983]


id: GO:0043565
name: sequence-specific DNA binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding." [GOC:jl]


id: GO:0043566
name: structure-specific DNA binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with DNA of a specific structure or configuration e.g. triplex DNA binding or bent DNA binding." [GOC:jl]


id: GO:0043567
name: regulation of insulin-like growth factor receptor signaling pathway
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of insulin-like growth factor receptor signaling." [GOC:bf]


id: GO:0043568
name: positive regulation of insulin-like growth factor receptor signaling pathway
namespace: biological_process
def:
  "Any process that increases the frequency, rate or extent of insulin-like growth factor receptor signaling." [GOC:bf]


id: GO:0043569
name: negative regulation of insulin-like growth factor receptor signaling pathway
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of insulin-like growth factor receptor signaling." [GOC:bf]


id: GO:0043571
name: maintenance of CRISPR repeat elements
namespace: biological_process
def:
  "Any process involved in sustaining CRISPR repeat clusters, including capture of new spacer elements, expansion or contraction of clusters, propagation of the leader sequence and repeat clusters within a genome, transfer of repeat clusters and CRISPR-associated (cas) genes to new genomes, transcription of the CRISPR repeat arrays into RNA and processing, and interaction of CRISPR/cas loci with the host genome. CRISPR (clustered regularly interspaced short palindromic repeat) elements are a family of sequence elements containing multiple direct repeats of 24-48 bp with weak dyad symmetry which are separated by regularly sized nonrepetitive spacer sequences." [PMID:16292354]


id: GO:0043572
name: plastid fission
namespace: biological_process
def:
  "The creation of two or more plastids by division of one plastid. A plastid is any member of a family of organelles found in the cytoplasm of plants and some protists, which are membrane-bounded and contain DNA." [GOC:jl]


id: GO:0043573
name: leucoplast fission
namespace: biological_process
def:
  "The creation of two or more leucoplasts by division of one leucoplast. A leucoplast is a colorless plastid involved in the synthesis of monoterpenes." [GOC:jl]


id: GO:0043574
name: peroxisomal transport
namespace: biological_process
def:
  "Transport of substances into, out of or within a peroxisome, a small, membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules." [GOC:jl]


id: GO:0043575
name: detection of osmotic stimulus
namespace: biological_process
def:
  "The series of events in which a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell is received and converted into a molecular signal." [GOC:jl]


id: GO:0043576
name: regulation of respiratory gaseous exchange
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of the process of gaseous exchange between an organism and its environment." [GOC:jl]


id: GO:0043577
name: chemotropism
namespace: biological_process
def:
  "The movement of an organism, or part of an organism, in response to an external chemical gradient, usually toward or away from it." [GOC:jl, PMID:10087613]


id: GO:0043578
name: nuclear matrix organization
namespace: biological_process
def:
  "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nuclear matrix, the dense fibrillar network lying on the inner side of the nuclear membrane." [GOC:dph, GOC:jl, GOC:mah]


id: GO:0043579
name: elaioplast organization
namespace: biological_process
def:
  "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an elaioplast, a leucoplast in which oil is stored." [GOC:jl]


id: GO:0043580
name: periplasmic space organization
namespace: biological_process
def:
  "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the periplasmic space, the region between the inner (cytoplasmic) and outer membrane in Gram-negative bacteria, or the inner membrane and cell wall in fungi." [GOC:dph, GOC:jl, GOC:mah]


id: GO:0043581
name: mycelium development
namespace: biological_process
def:
  "The process whose specific outcome is the progression of the mycelium over time, from its formation to the mature structure. A mycelium consists of a mass of branching, thread-like hyphae." [GOC:jl, ISBN:1580085792, PMID:12832397]


id: GO:0043582
name: sporangium development
namespace: biological_process
def:
  "The process whose specific outcome is the progression of the sporangium over time, from its formation to the mature structure. A sporangium is a structure producing and containing spores." [GOC:jl, Wikipedia:Sporagium]


id: GO:0043583
name: ear development
namespace: biological_process
def:
  "The process whose specific outcome is the progression of the ear over time, from its formation to the mature structure. The ear is the sense organ in vertebrates that is specialized for the detection of sound, and the maintenance of balance. Includes the outer ear and middle ear, which collect and transmit sound waves; and the inner ear, which contains the organs of balance and (except in fish) hearing. Also includes the pinna, the visible part of the outer ear, present in some mammals." [GOC:jl, ISBN:0192801023]


id: GO:0043584
name: nose development
namespace: biological_process
def:
  "The process whose specific outcome is the progression of the nose over time, from its formation to the mature structure. The nose is the specialized structure of the face that serves as the organ of the sense of smell and as part of the respiratory system. Includes the nasi externus (external nose) and cavitas nasi (nasal cavity)." [GOC:jl, http://www.mercksource.com/]


id: GO:0043585
name: nose morphogenesis
namespace: biological_process
def:
  "The process in which the anatomical structures of the nose are generated and organized. The nose is the specialized structure of the face that serves as the organ of the sense of smell and as part of the respiratory system. Includes the nasi externus (external nose) and cavitas nasi (nasal cavity)." [GOC:jl, http://www.mercksource.com/]


id: GO:0043586
name: tongue development
namespace: biological_process
def:
  "The process whose specific outcome is the progression of the tongue over time, from its formation to the mature structure. The tongue is the movable, muscular organ on the floor of the mouth of most vertebrates, in many other mammals is the principal organ of taste, aids in the prehension of food, in swallowing, and in modifying the voice as in speech." [GOC:jl, UBERON:0001723]


id: GO:0043587
name: tongue morphogenesis
namespace: biological_process
def:
  "The process in which the anatomical structures of the tongue are generated and organized. The tongue is the movable, muscular organ on the floor of the mouth of most vertebrates, in man other mammals is the principal organ of taste, aids in the prehension of food, in swallowing, and in modifying the voice as in speech." [GOC:jl, UBERON:0001723]


id: GO:0043588
name: skin development
namespace: biological_process
def:
  "The process whose specific outcome is the progression of the skin over time, from its formation to the mature structure. The skin is the external membranous integument of an animal. In vertebrates the skin generally consists of two layers, an outer nonsensitive and nonvascular epidermis (cuticle or skarfskin) composed of cells which are constantly growing and multiplying in the deeper, and being thrown off in the superficial layers, as well as an inner vascular dermis (cutis, corium or true skin) composed mostly of connective tissue." [GOC:jl, UBERON:0002097]


id: GO:0043589
name: skin morphogenesis
namespace: biological_process
def:
  "The process in which the anatomical structures of the skin are generated and organized. The skin is the external membranous integument of an animal. In vertebrates the skin generally consists of two layers, an outer nonsensitive and nonvascular epidermis (cuticle or skarfskin) composed of cells which are constantly growing and multiplying in the deeper, and being thrown off in the superficial layers, as well as an inner, sensitive and vascular dermis (cutis, corium or true skin) composed mostly of connective tissue." [GOC:jl, UBERON:0002097]


id: GO:0043591
name: endospore external encapsulating structure
namespace: cellular_component
def:
  "The structures that lie outside the inner membrane and surround the entire endospore; consists of a peptidoglycan-containing inner layer (the endospore cortex) surrounded by a multilayered proteinaceous coat. An exosporium may be present as an extreme outer layer." [GOC:go_curators, PMID:15035041]


id: GO:0043592
name: exosporium
namespace: cellular_component
def:
  "The outermost layer of a bacterial endospore, which is loosely attached and located outside of the endospore coat. It is generally composed of protein, carbohydrate, and perhaps lipid." [GOC:mlg]


id: GO:0043593
name: endospore coat
namespace: cellular_component
def:
  "The layer in a bacterial endospore that lies under the exosporium, and is impermeable to many toxic molecules. The coat may also contain enzymes that are involved in endospore germination." [GOC:mlg]


id: GO:0043594
name: outer endospore membrane
namespace: cellular_component
def:
  "The outer membrane around a bacterial endospore, located between the endospore cortex and endospore coat." [GOC:mlg]


id: GO:0043595
name: endospore cortex
namespace: cellular_component
def:
  "A layer surrounding a bacterial endospore found inside the outer endospore membrane, but outside the membrane surrounding the endospore core. It consists of peptidoglycan of a different chemical nature than that found in vegetative cell walls which results in less cross-linking of peptidoglycan." [GOC:mlg]


id: GO:0043596
name: nuclear replication fork
namespace: cellular_component
def:
  "The Y-shaped region of a nuclear replicating DNA molecule, resulting from the separation of the DNA strands and in which the synthesis of new strands takes place. Also includes associated protein complexes." [GOC:jl, GOC:mtg_sensu]


id: GO:0043597
name: cytoplasmic replication fork
namespace: cellular_component
def:
  "The Y-shaped region of a cytoplasmic replicating DNA molecule, resulting from the separation of the DNA strands and in which the synthesis of new strands takes place. Also includes associated protein complexes." [GOC:jl, GOC:mtg_sensu]


id: GO:0043598
name: cytoplasmic DNA replication factor C complex
namespace: cellular_component
def:
  "A cytoplasmic complex of two polypeptides that loads the DNA polymerase processivity factor proliferating cell nuclear antigen (PCNA) onto DNA, thereby permitting processive DNA synthesis catalyzed by DNA polymerase. Examples of this component are found in prokaryotic species." [GOC:mtg_sensu, PMID:14646196, PMID:16172520]


id: GO:0043599
name: nuclear DNA replication factor C complex
namespace: cellular_component
def:
  "A nuclear complex of five polypeptides that loads the DNA polymerase processivity factor proliferating cell nuclear antigen (PCNA) onto DNA, thereby permitting processive DNA synthesis catalyzed by DNA polymerase delta or epsilon. In Saccharomyces and several other species, the subunits are known as Rfc1p-Rfc5p, although subunit names do not necessarily correspond between different species." [GOC:mtg_sensu, PMID:14614842]


id: GO:0043600
name: cytoplasmic replisome
namespace: cellular_component
def:
  "A multi-component enzymatic machine at the cytoplasmic replication fork, which mediates DNA replication. Includes DNA primase, DNA polymerase, DNA helicase, and other proteins." [GOC:jl, GOC:mtg_sensu]


id: GO:0043601
name: nuclear replisome
namespace: cellular_component
def:
  "A multi-component enzymatic machine at the nuclear replication fork, which mediates DNA replication. Includes DNA primase, one or more DNA polymerases, DNA helicases, and other proteins." [GOC:jl, GOC:mtg_sensu]


id: GO:0043602
name: nitrate catabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the breakdown of nitrates, inorganic or organic salts and esters of nitric acid." [GOC:jl]


id: GO:0043603
name: cellular amide metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving an amide, any derivative of an oxoacid in which an acidic hydroxy group has been replaced by an amino or substituted amino group, as carried out by individual cells." [CHEBI:32988]


id: GO:0043604
name: amide biosynthetic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of an amide, any derivative of an oxoacid in which an acidic hydroxy group has been replaced by an amino or substituted amino group." [CHEBI:32988]


id: GO:0043605
name: cellular amide catabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the breakdown of an amide, any derivative of an oxoacid in which an acidic hydroxy group has been replaced by an amino or substituted amino group." [CHEBI:32988]


id: GO:0043606
name: formamide metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving formamide, the simplest amide, HCONH2, derived from formic acid." [GOC:jl, http://www.mercksource.com/]


id: GO:0043607
name: formamide biosynthetic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of formamide, the simplest amide, HCONH2, derived from formic acid." [GOC:jl, http://www.mercksource.com/]


id: GO:0043608
name: formamide catabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the breakdown of formamide, the simplest amide, HCONH2, derived from formic acid." [GOC:jl, http://www.mercksource.com/]


id: GO:0043614
name: multi-eIF complex
namespace: cellular_component
def:
  "A multifactor complex composed of multiple translation initiation factors and the initiatior tRNAiMet, which is ready to bind to the small (40S) ribosome to form the 43S preinitiation complex. In S. cerevisiae, this complex is composed of eIF1, eIF2, eIF3, and eIF5." [GOC:krc]


id: GO:0043615
name: astrocyte cell migration
namespace: biological_process
def:
  "The orderly movement of an astrocyte, a class of large neuroglial (macroglial) cells in the central nervous system, the largest and most numerous neuroglial cells in the brain and spinal cord." [CL:0000127, GOC:go_curators]


id: GO:0043616
name: keratinocyte proliferation
namespace: biological_process
def:
  "The multiplication or reproduction of keratinocytes, resulting in the expansion of a cell population. Keratinocytes are epidermal cells which synthesize keratin and undergo a characteristic change as they move upward from the basal layers of the epidermis to the cornified (horny) layer of the skin." [CL:0000311]


id: GO:0043617
name: cellular response to sucrose starvation
namespace: biological_process
def:
  "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of sucrose." [GOC:jl]


id: GO:0043618
name: regulation of transcription from RNA polymerase II promoter in response to stress
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:jl]


id: GO:0043619
name: regulation of transcription from RNA polymerase II promoter in response to oxidative stress
namespace: biological_process
def:
  "Modulation of the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a stimulus indicating the organism is under oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:jl]


id: GO:0043620
name: regulation of DNA-templated transcription in response to stress
namespace: biological_process
def:
  "Modulation of the frequency, rate or extent of transcription from a DNA template as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:jl, GOC:txnOH]


id: GO:0043622
name: cortical microtubule organization
namespace: biological_process
def:
  "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of structures formed of microtubules and associated proteins in the cell cortex, i.e. just beneath the plasma membrane of a cell." [GOC:curators, GOC:dph, GOC:jl, GOC:mah]


id: GO:0043623
name: cellular protein complex assembly
namespace: biological_process
def:
  "The aggregation, arrangement and bonding together of a set of components to form a protein complex, occurring at the level of an individual cell." [GOC:jl]


id: GO:0043624
name: cellular protein complex disassembly
namespace: biological_process
def:
  "The disaggregation of a protein complex into its constituent components, occurring at the level of an individual cell. Protein complexes may have other associated non-protein prosthetic groups, such as nucleic acids, metal ions or carbohydrate groups." [GOC:jl]


id: GO:0043625
name: delta DNA polymerase complex
namespace: cellular_component
def:
  "A multimeric DNA polymerase enzyme complex which differs in composition amongst species; in humans it is a heterotetramer of four subunits of approximately 125, 50, 68 and 12kDa, while in S. cerevisiae, it has three different subunits which form a heterotrimer, and the active enzyme is a dimer of this heterotrimer. Functions in DNA replication, mismatch repair and excision repair." [GOC:jl, ISBN:0198547684, PMID:11205330, PMID:12403614]


id: GO:0043626
name: PCNA complex
namespace: cellular_component
def:
  "A protein complex composed of three identical PCNA monomers, each comprising two similar domains, which are joined in a head-to-tail arrangement to form a homotrimer. Forms a ring-like structure in solution, with a central hole sufficiently large to accommodate the double helix of DNA. Originally characterized as a DNA sliding clamp for replicative DNA polymerases and as an essential component of the replisome, and has also been shown to be involved in other processes including Okazaki fragment processing, DNA repair, translesion DNA synthesis, DNA methylation, chromatin remodeling and cell cycle regulation." [GOC:jl, PMID:12829735]


id: GO:0043627
name: response to estrogen
namespace: biological_process
def:
  "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by an estrogen, C18 steroid hormones that can stimulate the development of female sexual characteristics." [GOC:jl, ISBN:0198506732]


id: GO:0043629
name: ncRNA polyadenylation
namespace: biological_process
def:
  "The enzymatic addition of a sequence of adenylyl residues at the 3' end of a non-coding RNA (ncRNA) molecule. In eukaryotes, substrates include nuclear non-coding RNAs such as precursors and a variety of incorrectly processed forms of snRNAs, snoRNAs, rRNAs, and tRNAs, as well as discarded RNA fragments which have been removed from ncRNA primary transcripts. Polyadenylation of precursors is often linked to termination of transcription, but polyadenylation of RNAs targeted for degradation may also occur post-transcriptionally. This polyadenylation is important both for 3'-end processing to produce mature ncRNA species and also for targeting incorrectly processed or discarded RNA molecules for degradation." [GOC:dgf, GOC:krc, GOC:rn, PMID:15828860, PMID:15935758, PMID:16374505, PMID:16431988, PMID:18951092]


id: GO:0043630
name: ncRNA polyadenylation involved in polyadenylation-dependent ncRNA catabolic process
namespace: biological_process
def:
  "The enzymatic addition of a sequence of adenylyl residues (polyadenylation) at the 3' end of a non-coding RNA, occurring as part of the process of polyadenylation-dependent non-coding RNA catabolism." [GOC:dph, GOC:jl, GOC:tb]


id: GO:0043631
name: RNA polyadenylation
namespace: biological_process
def:
  "The enzymatic addition of a sequence of adenylyl residues at the 3' end of an RNA molecule." [GOC:jl]


id: GO:0043632
name: modification-dependent macromolecule catabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the breakdown of a macromolecule, initiated by covalent modification of the target molecule." [GOC:jl]


id: GO:0043633
name: polyadenylation-dependent RNA catabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the breakdown of an RNA molecule, initiated by initiated by the enzymatic addition of a sequence of adenylyl residues (polyadenylation) at the 3'-end of the target RNA." [GOC:dgf, GOC:jl, GOC:krc]


id: GO:0043634
name: polyadenylation-dependent ncRNA catabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the breakdown of a noncoding RNA (ncRNA) molecule, initiated by the enzymatic addition of a sequence of adenylyl residues (polyadenylation) at the 3' end the target ncRNA." [GOC:dgf, GOC:jl, GOC:krc]


id: GO:0043635
name: methylnaphthalene catabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the breakdown of methylnaphthalene, an organic compound, C10H7CH3, obtained from coal tar." [GOC:jl, PMID:16535687]


id: GO:0043636
name: bisphenol A catabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the breakdown of bisphenol A, 4,4'-(propane-2,2-diyl)diphenol, a synthetic, aromatic organic compound used as a monomer in the manufacture of polycarbonate plastic and in the manufacture of epoxy resins." [CHEBI:33216, GOC:jl, Wikipedia:Bisphenol_A]


id: GO:0043637
name: puromycin metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving puromycin, 3'-deoxy-N,N-dimethyl-3'-(O-methyl-L-tyrosinamido)adenosine, an aminonucleoside antibiotic that is a potent inhibitor of translation; produced by the bacterium Streptomyces alboniger." [CHEBI:17939, GOC:jl, PMID:8226694, Wikipedia:Puromycin]


id: GO:0043638
name: puromycin biosynthetic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of puromycin, an aminonucleoside antibiotic that is a potent inhibitor of translation; produced by the bacterium Streptomyces alboniger." [CHEBI:17939, GOC:jl, Wikipedia:Puromycin]


id: GO:0043639
name: benzoate catabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the breakdown of benzoate, the anion of benzoic acid (benzenecarboxylic acid), a fungistatic compound widely used as a food preservative; it is conjugated to glycine in the liver and excreted as hippuric acid." [GOC:jl]


id: GO:0043640
name: benzoate catabolic process via hydroxylation
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the breakdown of benzoate, by its hydroxylation to cis-1,2-dihydroxybenzoate followed by dehydrogenation to catechol." [GOC:jl, MetaCyc:PWY-2503]


id: GO:0043641
name: novobiocin metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving novobiocin, a coumarin antibiotic produced by the bacterium Gyrasestreptomyces spheroides, that acts by inhibiting DNA gyrase." [CHEBI:28368, GOC:jl]


id: GO:0043642
name: novobiocin biosynthetic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of novobiocin, a coumarin antibiotic produced by the bacterium Gyrasestreptomyces spheroides, that acts by inhibiting DNA gyrase." [CHEBI:28368, GOC:jl]


id: GO:0043643
name: tetracycline metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving tetracycline, (4S,4aS,5aS,6S,12aS)-4-(dimethylamino)-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide, a broad-spectrum antibiotic produced by streptomyces bacteria that blocks binding of aminoacyl tRNA to the ribosomes of both Gram-positive and Gram-negative organisms (and those of organelles)." [CHEBI:27902, GOC:jl, Wikipedia:Tetracycline]


id: GO:0043644
name: tetracycline biosynthetic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of tetracycline, (4S,4aS,5aS,6S,12aS)-4-(dimethylamino)-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide, a broad-spectrum antibiotic produced by streptomyces bacteria that blocks binding of aminoacyl tRNA to the ribosomes of both Gram-positive and Gram-negative organisms (and those of organelles)." [CHEBI:27902, GOC:jl, Wikipedia:Tetracycline]


id: GO:0043645
name: cephalosporin metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving a cephalosporin, any of large class of tetracyclic triterpene broad-spectrum antibiotics similar both chemically and in their mode of action to penicillin, first isolated from the culture filtrates of mediterranean fungus acremonium (cephalosporium acremonium), and effective against gram-positive bacteria." [CHEBI:23066, GOC:jl, Wikipedia:Cephalosporin]


id: GO:0043646
name: cephalosporin biosynthetic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of a cephalosporin, any of large class of tetracyclic triterpene broad-spectrum antibiotics similar both chemically and in their mode of action to penicillin, first isolated from the culture filtrates of mediterranean fungus acremonium (cephalosporium acremonium), and effective against gram-positive bacteria." [CHEBI:23066, GOC:jl, Wikipedia:Cephalosporin]


id: GO:0043647
name: inositol phosphate metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving inositol phosphate, 1,2,3,4,5,6-cyclohexanehexol, with one or more phosphate groups attached." [CHEBI:24848, GOC:jl]


id: GO:0043648
name: dicarboxylic acid metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving dicarboxylic acids, any organic acid containing two carboxyl (COOH) groups or anions (COO-)." [ISBN:0198506732]


id: GO:0043649
name: dicarboxylic acid catabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the breakdown of dicarboxylic acids, any organic acid containing two carboxyl (-COOH) groups." [ISBN:0198506732]


id: GO:0043650
name: dicarboxylic acid biosynthetic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of dicarboxylic acids, any organic acid containing two carboxyl (-COOH) groups." [ISBN:0198506732]


id: GO:0043651
name: linoleic acid metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving linoleic acid, an unsaturated omega-6 fatty acid that has the molecular formula C18H32O2." [Wikipedia:Linoleic_Acid]


id: GO:0043652
name: engulfment of apoptotic cell
namespace: biological_process
def:
  "The removal of the apoptotic cell by phagocytosis, by a neighboring cell or by a phagocyte." [GOC:rk, PMID:15536015]


id: GO:0043653
name: mitochondrial fragmentation involved in apoptotic process
namespace: biological_process
def:
  "The change in the morphology of the mitochondria in an apoptotic cell from a highly branched network to a fragmented vesicular form." [GOC:mtg_apoptosis, GOC:rk, PMID:12867994]


id: GO:0043654
name: recognition of apoptotic cell
namespace: biological_process
def:
  "The process in which a cell interprets signals (in the form of specific proteins and lipids) on the surface of a dying cell which it will engulf and remove by phagocytosis." [GOC:rk, PMID:15536015]


id: GO:0043655
name: extracellular space of host
namespace: cellular_component
def:
  "The space within a host but external to the plasma membrane of host cells, e.g. within host bloodstream." [GOC:cc]


id: GO:0043657
name: host cell
namespace: cellular_component
def:
  "A cell within a host organism. Includes the host plasma membrane and any external encapsulating structures such as the host cell wall and cell envelope." [GOC:jl]


id: GO:0043658
name: host symbiosome
namespace: cellular_component
def:
  "A double-enveloped cell compartment, composed of the endosymbiont with its plasmalemma (as inner envelope) and an outer envelope (the perisymbiontic membrane) derived from the host cell." [GOC:cc]


id: GO:0043659
name: symbiosome
namespace: cellular_component
def:
  "A double-enveloped cell compartment, composed of an endosymbiont with its plasmalemma (as inner envelope) and a non-endosymbiotic outer envelope (the perisymbiontic membrane)." [GOC:cc]


id: GO:0043660
name: bacteroid-containing symbiosome
namespace: cellular_component
def:
  "A symbiosome containing any of various structurally modified bacteria, such as those occurring on the root nodules of leguminous plants." [GOC:cc]


id: GO:0043661
name: peribacteroid membrane
namespace: cellular_component
def:
  "A membrane that surrounds one or more bacteroids (such as nitrogen-fixing bacteroids within legume root nodule cells)." [GOC:cc]


id: GO:0043662
name: peribacteroid fluid
namespace: cellular_component
def:
  "The soluble material inside the peribacteroid membrane, but outside of the bacteroid, within a bacteroid-containing symbiosome." [GOC:cc]


id: GO:0043663
name: host bacteroid-containing symbiosome
namespace: cellular_component
def:
  "A symbiosome containing any of various structurally modified bacteria, such as those occurring on the root nodules of leguminous plants, of a host cell." [GOC:cc]


id: GO:0043664
name: host peribacteroid membrane
namespace: cellular_component
def:
  "A host-derived membrane that surrounds one or more bacteroids (such as nitrogen-fixing bacteroids within legume root nodule cells)." [GOC:cc]


id: GO:0043665
name: host peribacteroid fluid
namespace: cellular_component
def:
  "The soluble material inside the peribacteroid membrane, but outside of the bacteroid, within a bacteroid-containing symbiosome of a host cell." [GOC:cc]


id: GO:0043666
name: regulation of phosphoprotein phosphatase activity
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of phosphoprotein phosphatase activity, the catalysis of the hydrolysis of phosphate from a phosphoprotein." [GOC:jp, PMID:11724821]


id: GO:0043668
name: exine
namespace: cellular_component
def:
  "The outer layer of the pollen grain wall which is composed primarily of sporopollenin." [http://www.mobot.org/MOBOT/research/APweb/]


id: GO:0043669
name: ectexine
namespace: cellular_component
def:
  "The outer part of the exine, which stains positively with basic fuchsin in optical microscopy and has higher electron density in conventionally prepared TEM sections." [http://www.mobot.org/MOBOT/research/APweb/]


id: GO:0043672
name: nexine
namespace: cellular_component
def:
  "The inner, non-sculptured part of the exine which lies below the sexine." [http://www.mobot.org/MOBOT/research/APweb/]


id: GO:0043673
name: sexine
namespace: cellular_component
def:
  "The outer, sculptured layer of the exine, which lies above the nexine." [http://www.mobot.org/MOBOT/research/APweb/]


id: GO:0043674
name: columella
namespace: cellular_component
def:
  "A rod-like element of the sexine and ectexine, supporting either the tectum (the layer of sexine which forms a roof over the columella), or supporting a caput (an architectural element on top of a columella)." [http://www.mobot.org/MOBOT/research/APweb/]


id: GO:0043676
name: tectum
namespace: cellular_component
def:
  "The layer of sexine which forms a roof over the columella, granules or other infratectal elements." [http://www.mobot.org/MOBOT/research/APweb/]


id: GO:0043677
name: germination pore
namespace: cellular_component
def:
  "A small pore in the outer wall of a mycelial spore through which the germ tube exits upon germination. It can be apical or eccentric in its location." [Wikipedia:Germ_pore]


id: GO:0043678
name: intine
namespace: cellular_component
def:
  "The innermost of the major layers of the pollen grain wall which underlies the exine and borders the cytoplasm." [http://www.mobot.org/MOBOT/research/APweb/]


id: GO:0043679
name: axon terminus
namespace: cellular_component
def:
  "Terminal inflated portion of the axon, containing the specialized apparatus necessary to release neurotransmitters. The axon terminus is considered to be the whole region of thickening and the terminal button is a specialized region of it." [GOC:dph, GOC:jl]


id: GO:0043680
name: filiform apparatus
namespace: cellular_component
def:
  "A complex of cell wall invaginations in a synergid cell, similar to those in transfer cells." [ISBN:0471245208]


id: GO:0043682
name: copper-transporting ATPase activity
namespace: molecular_function
def:
  "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Cu2+ = ADP + phosphate + Cu2+, directly driving the transport of the copper ions across a membrane." [GOC:jl]


id: GO:0043683
name: type IV pilus biogenesis
namespace: biological_process
def:
  "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a type IV pilus. A type IV pilus is composed of a pilus fiber and approximately ten proteins at its base; type IV pili play a role in cell motility, adherence to substrates, and aggregation." [GOC:jl, GOC:ml]


id: GO:0043684
name: type IV secretion system complex
namespace: cellular_component
def:
  "A complex of proteins related to those involved in bacterial DNA conjugative transfer, that permits the transfer of DNA or proteins into the extracellular milieu or directly into host cells. In general the type IV complex forms a multisubunit cell-envelope-spanning structure composed of a secretion channel and often a pilus or other surface filament or protein(s)." [GOC:ml]


id: GO:0043685
name: conversion of glutamyl-tRNA to glutaminyl-tRNA
namespace: biological_process
def:
  "The modification process that results in the conversion of glutamate charged on a tRNA(Gln) to glutaminyl-tRNA." [GOC:jsg, PMID:3340166, PMID:9342308]


id: GO:0043686
name: co-translational protein modification
namespace: biological_process
def:
  "The process of covalently altering one or more amino acids in a protein after translation has begun but before the protein has been released from the ribosome." [GOC:jsg]


id: GO:0043687
name: post-translational protein modification
namespace: biological_process
def:
  "The process of covalently altering one or more amino acids in a protein after the protein has been completely translated and released from the ribosome." [GOC:jsg]


id: GO:0043688
name: conversion of aspartyl-tRNA to asparaginyl-tRNA
namespace: biological_process
def:
  "The modification process that results in the conversion of aspartate charged on a tRNA(Asn) to asparaginyl-tRNA." [GOC:jsg, PMID:9789001]


id: GO:0043689
name: cell-cell adhesion involved in flocculation
namespace: biological_process
def:
  "The attachment of one single cell organism to another via adhesion molecules, occurring as a part of flocculation." [GOC:dos, GOC:jl]


id: GO:0043690
name: cell-cell adhesion involved in flocculation via cell wall protein-carbohydrate interaction
namespace: biological_process
def:
  "The attachment of one single cell organism to another during flocculation via the interaction a protein in the cell wall of one cell with a carbohydrate in the cell wall of another  In Saccharomyces this process is mannose-sensitive." [GOC:dos, GOC:jl]


id: GO:0043691
name: reverse cholesterol transport
namespace: biological_process
def:
  "The directed movement of peripheral cell cholesterol, cholest-5-en-3-beta-ol, towards the liver for catabolism." [GOC:ecd, PMID:7751809]


id: GO:0043692
name: monoterpene metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving monoterpenes, terpenes with a C10 structure." [CHEBI:35187]


id: GO:0043693
name: monoterpene biosynthetic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of monoterpenes, terpenes with a C10 structure." [CHEBI:35187]


id: GO:0043694
name: monoterpene catabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the breakdown of monoterpenes, terpenes with a C10 structure." [CHEBI:35187]


id: GO:0043695
name: detection of pheromone
namespace: biological_process
def:
  "The series of events in which a pheromone stimulus is received by a cell and converted into a molecular signal." [GOC:mah]


id: GO:0043696
name: dedifferentiation
namespace: biological_process
def:
  "The process in which a specialized structure (cell, tissue or organ) loses structural or functional features that characterize it in the mature organism, or some other relatively stable phase of the organism's life history. Under certain conditions, these structures can revert back to the features of their ancestors." [GOC:dph, GOC:pg]


id: GO:0043697
name: cell dedifferentiation
namespace: biological_process
def:
  "The process in which a specialized cell loses the structural or functional features that characterize it in the mature organism, or some other relatively stable phase of the organism's life history. Under certain conditions, these cells can revert back to the features of the stem cells that were their ancestors." [GOC:dph, GOC:pg]


id: GO:0043698
name: iridosome
namespace: cellular_component
def:
  "A tissue-specific, membrane-bounded cytoplasmic organelle within which purines crystalize in reflective stacks. Iridosomes are synthesized in iridophore cells and are silver, gold or iridescent in appearance." [GOC:mh]


id: GO:0043699
name: leucosome
namespace: cellular_component
def:
  "A tissue-specific, membrane-bounded cytoplasmic organelle within which uric acid and/or purines crystalize in reflective stacks. Leucosomes are synthesized in leucophore cells and have a whitish cast." [GOC:mh]


id: GO:0043700
name: pterinosome
namespace: cellular_component
def:
  "A tissue-specific, membrane-bounded cytoplasmic organelle within which pteridine pigments are synthesized and stored. Pterinosomes are synthesized in xanthophores and erythrophore cells and are yellow, orange or red in appearance." [GOC:mh]


id: GO:0043701
name: cyanosome
namespace: cellular_component
def:
  "A tissue-specific, membrane-bounded cytoplasmic organelle within which an unknown blue pigment is localized. Cyanosomes are synthesized in cyanophores and are blue in appearance." [GOC:mh]


id: GO:0043702
name: carotenoid vesicle
namespace: cellular_component
def:
  "A tissue-specific cytoplasmic vesicle surrounded by a membrane half-leaflet within which carotenoid pigments are stored. Carotenoid vesicles are synthesized in xanthophores and erythrophore cells and are yellow, orange or red in appearance." [GOC:mh]


id: GO:0043703
name: photoreceptor cell fate determination
namespace: biological_process
def:
  "The process in which a cell becomes capable of differentiating autonomously into a photoreceptor cell regardless of its environment; upon determination, the cell fate cannot be reversed." [GOC:mtg_sensu]


id: GO:0043704
name: photoreceptor cell fate specification
namespace: biological_process
def:
  "The process in which a cell becomes capable of differentiating autonomously into a photoreceptor cell in an environment that is neutral with respect to the developmental pathway. Upon specification, the cell fate can be reversed." [GOC:mtg_sensu]


id: GO:0043705
name: cyanophycin metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving cyanophycin, a non-protein, non-ribosomally produced amino acid polymer composed of an aspartic acid backbone and arginine side groups." [GOC:jl]


id: GO:0043706
namespace: biological_process
name:
  heterophilic cell adhesion involved in cytoadherence to microvasculature, mediated by parasite protein

def:
  "The attachment of an erythrocyte to the microvasculature via a parasite cell adhesion molecule. This may be via attachment to host endothelial cell ECM or to endothelial cell adhesion molecules. An example of this occurs during infection with the malaria parasite." [GOC:jl, PMID:10362584, PMID:23376131]


id: GO:0043707
name: cell adhesion involved in single-species biofilm formation in or on host organism
namespace: biological_process
def:
  "The attachment of a cell to either a host cell or a microbial cell of the same species, or to an underlying host substrate, such as the extracellular matrix, via cell adhesion molecules, occurring during the formation of a biofilm in or on a host species." [GOC:jl]


id: GO:0043708
name: cell adhesion involved in biofilm formation
namespace: biological_process
def:
  "The attachment of a cell to a solid substrate, via cell adhesion molecules, contributing to the formation of a biofilm." [GOC:dph, GOC:jl, GOC:tb]


id: GO:0043709
name: cell adhesion involved in single-species biofilm formation
namespace: biological_process
def:
  "The attachment of a cell to a solid substrate, via cell adhesion molecules, during the formation of a biofilm composed of microorganisms of the same species." [GOC:dph, GOC:jl, GOC:tb]


id: GO:0043710
name: cell adhesion involved in multi-species biofilm formation
namespace: biological_process
def:
  "The attachment of a cell to a solid substrate, via cell adhesion molecules, contributing to the formation of a biofilm composed of microorganisms of different species." [GOC:dph, GOC:jl, GOC:tb]


id: GO:0043711
name: pilus organization
namespace: biological_process
def:
  "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a pilus, a short filamentous structure on a bacterial cell, flagella-like in structure and generally present in many copies." [GOC:jl]


id: GO:0043712
name: 2-hydroxyisocaproate CoA-transferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: (R)-2-hydroxyisocaproate + isocaproyl-CoA = (R)-2-hydroxyisocaproyl-CoA + isocaproate." [PMID:16957230]


id: GO:0043713
name: (R)-2-hydroxyisocaproate dehydrogenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 2-oxoisocaproate + NADH + H+ = (R)-2-hydroxyisocaproate + NAD+." [GOC:jl, PMID:16957230]


id: GO:0043714
name: (R)-citramalate synthase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: pyruvate + acetyl-CoA + H2O = (R)-citramalate + CoA." [GOC:jl, PMID:9864346]


id: GO:0043715
name: 2,3-diketo-5-methylthiopentyl-1-phosphate enolase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 2,3-diketo-5-methylthiopentyl-1-phosphate = H+ + 2-hydroxy 3-keto-5-methylthiopentenyl-1-phosphate. 2,3-diketo-5-methylthiopentyl-1-phosphate is also known as DK-MTP-1-P, and 2-hydroxy 3-keto-5-methylthiopentenyl-1-phosphate as HK-MTPenyl-1-P." [MetaCyc:R82-RXN]


id: GO:0043716
name: 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate phosphatase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate + H2O = 1,2-dihydroxy-5-(methylthio)pent-1-en-3-one + phosphate. 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate is also known as HK-MTPenyl-P, and 1,2-dihydroxy-3-keto-5-methylthiopentene as DHK-MTPene." [EC:3.1.3.77, IMG:01681, MetaCyc:R83-RXN]


id: GO:0043718
name: 2-hydroxymethylglutarate dehydrogenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 2-(hydroxymethyl)glutarate + NAD(+) = 2-formylglutarate + H(+) + NADH." [EC:1.1.1.291, RHEA:15508]


id: GO:0043719
name: 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol + O2 + H+ = 2-octaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinol + H2O." [GOC:jl, MetaCyc:OCTAPRENYL-METHYL-METHOXY-BENZOQ-OH-RXN]


id: GO:0043720
name: 3-keto-5-aminohexanoate cleavage activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 3-keto-5-aminohexanoate + acetyl-CoA = L-3-aminobutyryl-CoA + acetoacetate." [MetaCyc:R125-RXN, PMID:13064]


id: GO:0043722
name: 4-hydroxyphenylacetate decarboxylase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: (4-hydroxyphenyl)acetate + H(+) = 4-cresol + CO(2)." [EC:4.1.1.83, RHEA:22735]


id: GO:0043723
name: 2,5-diamino-6-ribitylamino-4(3H)-pyrimidinone 5'-phosphate deaminase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 2,5-diamino-6-(5-phospho-D-ribitylamino)pyrimidin-4(3H)-one + H2O = 5-amino-6-(5-phospho-D-ribosylamino)uracil + ammonia." [MetaCyc:RXN-10058, PMID:11889103]


id: GO:0043724
name: 2-keto-3-deoxygalactonate aldolase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 2-keto-3-deoxygalactonate = D-glyceraldehyde + pyruvate." [PMID:12824170]


id: GO:0043726
name: 5-amino-6-(5-phosphoribitylamino)uracil phosphatase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 5-amino-6-(5-phosphoribitylamino)-2,4(1H,3H)-pyrimidinedione + H2O = 5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione + orthophosphate." [GOC:jl, IMG:01282]


id: GO:0043727
name: 5-amino-4-imidazole carboxylate lyase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 5-aminoimidazole + CO2 = 5-amino-4-imidazole carboxylate." [GOC:jl, IMG:01835]


id: GO:0043728
name: 2-keto-4-methylthiobutyrate aminotransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 2-keto-4-methylthiobutyrate + L-glutamine = 2-oxoglutaramate + L-methionine." [GOC:jl, IMG:01683]


id: GO:0043729
name: 2-amino-5-formylamino-6-(5-phosphoribosylamino)pyrimidin-4(3H)-one formate-lyase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 2-amino-5-formylamino-6-(5-phosphoribosylamino)pyrimidin-4(3H)-one + H2O = 2,5-diamino-6-(5-phosphoribosylamino)pyrimidin-4(3H)-one + formate." [GOC:jl, IMG:01536]


id: GO:0043730
name: 5-ureido-4-imidazole carboxylate hydrolase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 5-ureido-4-imidazole carboxylate + H2O = 5-amino-4-imidazole carboxylate + NH3 + CO2." [GOC:jl, IMG:02121]


id: GO:0043731
name: 6-hydroxynicotinate 3-monooxygenase activity
namespace: molecular_function
def:
  "Catalysis of the oxidative decarboxylation of 6-hydroxynicotinate to 2,5-dihydroxypyridine, dependent on O2, NADH +H+ and FAD." [GOC:jl, PMID:10091591]


id: GO:0043732
name: 6-hydroxynicotinate dehydrogenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 6-hydroxynicotinate + H(2)O + O(2) = 2,6-dihydroxynicotinate + H(2)O(2)." [EC:1.17.3.3, RHEA:22811]


id: GO:0043733
name: DNA-3-methylbase glycosylase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: DNA containing 3-methylbase + H2O = DNA with abasic site + 3-methylbase. This reaction is the hydrolysis of DNA by cleavage of the N-C1' glycosidic bond between the damaged DNA 3-methylpurine or 3-methylpyrimidine base and the deoxyribose sugar to remove the methylated base, leaving an apurinic or apyrimidinic site." [IMG:00576, PMID:10777493, PMID:14517230]


id: GO:0043734
name: DNA-N1-methyladenine dioxygenase activity
namespace: molecular_function
def:
  "Catalysis of the oxidative demethylation of N1-methyladenine and N3-methylcytosine in DNA and RNA, with concomitant decarboxylation of 2-oxoglutarate and releases oxidized methyl group on N1-methyladenine and N3-methylcytosine as formaldehyde." [IMG:00579, PMID:19786499]


id: GO:0043736
name: obsolete DNA-3-methyladenine glycosylase IV activity
namespace: molecular_function
def:
  "OBSOLETE. Catalysis of the hydrolysis of alkylated DNA; recognizes and removes both N-3- and N-7-methyl purines by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic (AP) site." [IMG:00578, PMID:10375529]


id: GO:0043737
name: deoxyribonuclease V activity
namespace: molecular_function
def:
  "Catalysis of the endonucleolytic cleavage at apurinic or apyrimidinic sites to products with a 5'-phosphate." [EC:3.1.21.7]


id: GO:0043738
name: reduced coenzyme F420 dehydrogenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: methanophenazine + reduced coenzyme F420 = dihydromethanophenazine + coenzyme F420." [MetaCyc:RXN-8106]


id: GO:0043739
name: G/U mismatch-specific uracil-DNA glycosylase activity
namespace: molecular_function
def:
  "Catalysis of the removal of uracil from a U*G mispair by the cleavage the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free uracil and leaves an apyrimidinic (AP) site." [IMG:00570, SP:O59825]


id: GO:0043740
name: GTP cyclohydrolase IIa activity
namespace: molecular_function
def:
  "Catalysis of the reaction: GTP + 3 H(2)O = 2-amino-5-formylamino-6-(1-D-ribosylamino)pyrimidin-4(3H)-one 5'-phosphate + 3 H(+) + 2 phosphate." [EC:3.5.4.29, RHEA:22471]


id: GO:0043741
name: L-2-aminoadipate N-acetyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: L-2-aminoadipate + acetyl-CoA = N2-acetyl-L-aminoadipate + CoA." [IMG:01447]


id: GO:0043743
name: LPPG:FO 2-phospho-L-lactate transferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 7,8-didemethyl-8-hydroxy-5-deazariboflavin + lactyl-2-diphospho-5'-guanosine = coenzyme F420-0 + GMP." [IMG:01551]


id: GO:0043744
name: N2-acetyl-L-aminoadipate kinase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: ATP + N-acetyl-L-aminoadipate = ADP + N-acetyl-L-aminoadipate 5-phosphate." [IMG:01448]


id: GO:0043745
name: N2-acetyl-L-aminoadipate semialdehyde dehydrogenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: N2-acetyl-L-aminoadipyl-delta-phosphate + NADPH + H+ = N2-acetyl-L-aminoadipate semialdehyde + NADP+ + orthophosphate." [IMG:01449]


id: GO:0043746
name: N2-acetyl-L-lysine aminotransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: N2-acetyl-L-aminoadipate semialdehyde + L-glutamate = 2-oxoglutarate + N2-acetyl-L-lysine." [IMG:01450]


id: GO:0043748
name: O-succinylbenzoate synthase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 2-succinylbenzoate + H2O = 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate." [IMG:01733]


id: GO:0043749
name: phenol, water dikinase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: phenol + MgATP + H2O = phenylphosphate + MgAMP + orthophosphate." [PMID:15547277]


id: GO:0043750
name: phosphatidylinositol alpha-mannosyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the transfer of one or more alpha-D-mannose residues from GDP-mannose to positions 2,6 and others in 1-phosphatidyl-myo-inositol." [EC:2.4.1.57]


id: GO:0043752
name: adenosylcobinamide kinase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: RTP + adenosylcobinamide = adenosylcobinamide phosphate + RDP (where RTP is either ATP or GTP)." [EC:2.7.1.156]


id: GO:0043754
name: dihydrolipoyllysine-residue (2-methylpropanoyl)transferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 2-methylpropanoyl-CoA + enzyme N6-(dihydrolipoyl)lysine = CoA + enzyme N6-(S-[2-methylpropanoyl]dihydrolipoyl)lysine." [EC:2.3.1.168]


id: GO:0043755
name: alpha-ribazole phosphatase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: alpha-ribazole 5'-phosphate + H(2)O = alpha-ribazole + phosphate." [EC:3.1.3.73, RHEA:24459]


id: GO:0043756
name: adenosylcobinamide hydrolase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: adenosylcobinamide + H(2)O = (R)-1-aminopropan-2-ol + adenosylcobyrate." [EC:3.5.1.90, RHEA:23507]


id: GO:0043757
name: adenosylcobinamide-phosphate synthase activity
namespace: molecular_function
def:
  "Catalysis of the reactions: ATP + adenosylcobyric acid + (R)-1-aminopropan-2-yl phosphate = ADP + phosphate + adenosylcobinamide phosphate, and ATP + adenosylcobyric acid + (R)-1-aminopropan-2-ol = ADP + phosphate + adenosylcobinamide." [EC:6.3.1.10]


id: GO:0043759
name: branched-chain acyl-CoA synthetase (ADP-forming) activity
namespace: molecular_function
def:
  "Catalysis of the reaction: ATP + 2-methylbutanoate + CoA = ADP + orthophosphate + 2-methylbutanoyl-CoA." [IMG:01425]


id: GO:0043760
name: acetyldiaminopimelate aminotransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: N-acetyl-L-2,6-diaminoheptanedioate + 2-oxoglutarate = N-acetyl-2-L-amino-6-oxoheptanedioate + L-glutamate." [IMG:00444, PMID:1906065]


id: GO:0043761
name: archaetidylserine synthase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: CDP-digeranylgeranylglycerol + L-serine = archaetidylserine + CMP." [IMG:01567, PMID:12562787]


id: GO:0043762
name: aryl-CoA synthetase (ADP-forming) activity
namespace: molecular_function
def:
  "Catalysis of the reaction: ATP + phenylacetate + CoA = ADP + orthophosphate + phenylacetyl-CoA." [IMG:01427]


id: GO:0043764
name: UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: UDP-3-O-(3-hydroxytetradecanoyl)glucosamine + (R)-3-hydroxytetradecanoyl-[acyl-carrier protein] = UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + [acyl-carrier protein]." [IMG:00545, InterPro:IPR007691]


id: GO:0043765
name: T/G mismatch-specific endonuclease activity
namespace: molecular_function
def:
  "Catalysis of the repair of T/G mismatches arising from deamination of 5-methylcytosine in DNA by nicking double-stranded DNA within the sequence CT(AT)GN or NT(AT)GG next to the mismatched thymidine residue. The incision is mismatch-dependent and strand-specific, in favor of the G-containing strand. The incision serves as a starting point for subsequent excision repair by DNA polymerase I, which excises thymidine and reinserts cytidine." [IMG:00606, SP:P09184]


id: GO:0043766
name: Sep-tRNA:Cys-tRNA synthase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: O-phospho-L-seryl-tRNACys + sulfide = L-cysteinyl-tRNACys + phosphate." [EC:2.5.1.73, IMG:00235, PMID:15790858, PMID:16380427, PMID:17110438]


id: GO:0043767
name: pyrrolysyl-tRNA synthetase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: ATP + L-pyrrolysine + tRNA(Pyl) = AMP + diphosphate + L-pyrrolysyl-tRNA(Pyl)." [IMG:02553, PMID:15314242, SP:Q8TUB8]


id: GO:0043768
name: S-ribosylhomocysteine lyase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: S-(5-deoxy-D-ribos-5-yl)-L-homocysteine = (S)-4,5-dihydroxypentane-2,3-dione + L-homocysteine." [EC:4.4.1.21, RHEA:17756]


id: GO:0043769
name: Tpg-containing telomere binding complex
namespace: cellular_component
def:
  "A complex composed of four polypeptides, a telomere-protecting terminal protein (Tpg), a telomere-associated protein (Tap), DNA polymerase (PolA) and topoisomerase I (TopA), that functions in the replication of the telomeric regions of linear chromosomes, plasmids and circular replicons of some bacterial species." [PMID:15353591]


id: GO:0043770
name: demethylmenaquinone methyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 2-demethylmenaquinone + S-adenosyl-L-methionine = menaquinone + S-adenosyl-L-homocysteine." [IMG:01848]


id: GO:0043772
name: acyl-phosphate glycerol-3-phosphate acyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: acyl phosphate + sn-glycerol 3-phosphate = 1-acyl-sn-glycerol 3-phosphate + orthophosphate." [IMG:01872, PMID:17308305]


id: GO:0043773
name: coenzyme F420-0 gamma-glutamyl ligase activity
namespace: molecular_function
def:
  "Catalysis of the reactions: (1) GTP + F420-0 + L-glutamate = GDP + phosphate + F420-1, and (2) GTP + F420-1 + L-glutamate = GDP + phosphate + gamma-F420-2. This is the GTP-dependent successive addition of two L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form F420-0-glutamyl-glutamate (F420-2), with a gamma-linkage between the two glutamates." [IMG:01552, PMID:17669425]


id: GO:0043774
name: coenzyme F420-2 alpha-glutamyl ligase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: coenzyme F420-2 + L-glutamate + GTP = coenzyme F420-3 + GDP + orthophosphate." [IMG:01553]


id: GO:0043775
name: cobyrinate a,c-diamide synthase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: cobyrinate + 2 L-glutamine + 2 ATP + 2 H2O = cob(II)yrinate a,c-diamide + 2 L-glutamate + 2 ADP + 2 orthophosphate." [IMG:01814]


id: GO:0043776
name: cobalt-precorrin-6B C5-methyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: S-adenosylmethionine + cobalt-precorrin 6B = S-adenosylhomocysteine + cobalt-precorrin 7." [IMG:02115, MetaCyc:RXN-8766]


id: GO:0043777
name: cobalt-precorrin-7 C15-methyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: cobalt-precorrin 7 + S-adenosyl-L-methionine = cobalt-precorrin 8 + S-adenosyl-L-homocysteine + CO2." [IMG:02116, MetaCyc:RXN-8767]


id: GO:0043779
name: cobalt-precorrin-5A acetaldehyde-lyase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: cobalt-precorrin 5A + H2O = cobalt-precorrin 5B + acetaldehyde." [IMG:02112, MetaCyc:RXN-8763]


id: GO:0043780
name: cobalt-precorrin-5B C1-methyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: cobalt-precorrin 5B + S-adenosylmethionine = S-adenosylhomocysteine + cobalt-precorrin 6A." [IMG:02112, MetaCyc:RXN-8764]


id: GO:0043781
name: cobalt-factor II C20-methyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: S-adenosyl-L-methionine + cobalt-factor II = S-adenosyl-L-homocysteine + cobalt-factor III." [EC:2.1.1.151, IMG:01812]


id: GO:0043782
name: cobalt-precorrin-3 C17-methyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: cobalt-precorrin 3 + S-adenosyl-L-methionine = cobalt-precorrin 4 + S-adenosyl-L-homocysteine." [IMG:02110, MetaCyc:RXN-8761]


id: GO:0043783
name: oxidoreductase activity, oxidizing metal ions with flavin as acceptor
namespace: molecular_function
def:
  "Catalysis of an oxidation-reduction in which the oxidation state of metal ion is altered and flavin acts as an electron acceptor." [EC:1.16.8]


id: GO:0043784
name: cob(II)yrinic acid a,c-diamide reductase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 2 cob(I)yrinate a,c diamide + FMN + 3 H(+) = 2 cob(II)yrinate a,c diamide + FMNH(2)." [EC:1.16.8.1, RHEA:24303]


id: GO:0043785
name: cinnamoyl-CoA:phenyllactate CoA-transferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: (R)-3-phenyllactate + [(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonatooxy)oxolan-2-yl]methyl {[(3R)-3-hydroxy-2,2-dimethyl-3-({2-[(2-{[(2E)-3-phenylprop-2-enoyl]sulfanyl}ethyl)carbamoyl]ethyl}carbamoyl)propyl phosphonato]oxy}phosphonate = (R)-3-phenyllactoyl-CoA + trans-cinnamate." [EC:2.8.3.17, RHEA:15604]


id: GO:0043786
name: cinnamate reductase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 3-phenylpropanoate + NAD+ = (E)-cinnamate + NADH + H+." [EC:1.3.1.-, IMG:01615, PMID:10849007]


id: GO:0043791
name: dimethylamine methyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: dimethylamine + a dimethylamine corrinoid protein = a methylated dimethylamine corrinoid protein + methylamine." [IMG:01321, MetaCyc:RXN-8100, PMID:9874228]


id: GO:0043792
name: enamidase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 1,4,5,6-tetrahydro-6-oxonicotinate + 2 H(2)O = 2-formylglutarate + NH(4)(+)." [EC:3.5.2.18, RHEA:17212]


id: GO:0043793
name: beta-ribofuranosylaminobenzene 5'-phosphate synthase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 4-aminobenzoate + 5-phospho-alpha-D-ribose 1-diphosphate = 4-(beta-D-ribofuranosyl)aminobenzene 5'-phosphate + CO2 + diphosphate." [GOC:jl, IMG:01544, PMID:12142414]


id: GO:0043794
name: formate dehydrogenase (coenzyme F420) activity
namespace: molecular_function
def:
  "Catalysis of the reaction: formate + coenzyme F420 = CO2 + reduced coenzyme F420." [IMG:01432, PMID:3801411]


id: GO:0043795
name: glyceraldehyde oxidoreductase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: D-glyceraldehyde + H2O + acceptor = D-glycerate + reduced acceptor." [IMG:01506]


id: GO:0043797
name: glyceraldehyde-3-phosphate dehydrogenase (ferredoxin) activity
namespace: molecular_function
def:
  "Catalysis of the reaction: D-glyceraldehyde-3-phosphate + H2O + 2 oxidized ferredoxin = 3-phospho-D-glycerate + 2 H+ + 2 reduced ferredoxin." [EC:1.2.7.6]


id: GO:0043798
name: glycerate 2-kinase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: D-glycerate + ATP = 2-phospho-D-glycerate + ADP." [IMG:01510, MetaCyc:GKI-RXN, PMID:14413719]


id: GO:0043799
name: glycine oxidase activity
namespace: molecular_function
def:
  "Catalysis of the reactions: (1) glycine + H2O + O2 = glyoxylate + NH3 + hydrogen peroxide; (2) D-alanine + H2O + O2 = pyruvate + NH3 + hydrogen peroxide; (3) sarcosine + H2O + O2 = glyoxylate + methylamine + hydrogen peroxide; (4) N-ethylglycine + H2O + O2 = glyoxylate + ethylamine + hydrogen peroxide." [EC:1.4.3.19]


id: GO:0043800
name: hexulose-6-phosphate isomerase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: D-arabino-3-hexulose 6-phosphate = D-fructose 6-phosphate." [IMG:01502, MetaCyc:R12-RXN, PMID:11839305]


id: GO:0043801
name: hexulose-6-phosphate synthase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: D-ribulose 5-phosphate + formaldehyde = D-arabino-3-hexulose 6-phosphate." [IMG:01503, PMID:16075199]


id: GO:0043802
name: hydrogenobyrinic acid a,c-diamide synthase (glutamine-hydrolysing) activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 2 L-glutamine + 2 ATP + 2 H(2)O + hydrogenobyrinate = 2 L-glutamate + 2 ADP + 4 H(+) + hydrogenobyrinate a,c-diamide + 2 phosphate." [EC:6.3.5.9, RHEA:12547]


id: GO:0043803
name: hydroxyneurosporene-O-methyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: demethylspheroidene + S-adenosyl-L-methionine = spheroidene + S-adenosyl-L-homocysteine." [IMG:01759]


id: GO:0043805
name: indolepyruvate ferredoxin oxidoreductase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: (indol-3-yl)pyruvate + CoA + oxidized ferredoxin = S-2-(indol-3-yl)acetyl-CoA + CO2 + reduced ferredoxin." [EC:1.2.7.8]


id: GO:0043806
name: keto acid formate lyase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 2-oxobutanoate + CoA = propionyl-CoA + formate." [IMG:00725, MetaCyc:KETOBUTFORMLY-RXN]


id: GO:0043807
name: 3-methyl-2-oxobutanoate dehydrogenase (ferredoxin) activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 3-methyl-2-oxobutanoate + CoA + oxidized ferredoxin = S-(2-methylpropanoyl)-CoA + CO2 + reduced ferredoxin." [EC:1.2.7.7]


id: GO:0043808
name: lyso-ornithine lipid acyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: lyso-ornithine lipid + acyl-[acyl-carrier protein] = ornithine lipid + [acyl-carrier protein]." [IMG:02097, PMID:15341653]


id: GO:0043810
name: ornithine-acyl [acyl carrier protein] N-acyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: (3R)-3-hydroxyacyl-[acyl-carrier protein] + L-ornithine = lyso-ornithine lipid + [acyl-carrier protein]." [IMG:02096]


id: GO:0043811
name: phosphate:acyl-[acyl carrier protein] acyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: acyl-[acyl-carrier protein] + orthophosphate = acyl phosphate + [acyl-carrier protein]." [IMG:01871]


id: GO:0043812
name: phosphatidylinositol-4-phosphate phosphatase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: phosphatidylinositol-4-phosphate + H2O = phosphatidylinositol + orthophosphate." [IMG:01360]


id: GO:0043813
name: phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: phosphatidylinositol-3,5-bisphosphate + H2O = phosphatidylinositol-3-phosphate + orthophosphate." [IMG:01359, PMID:10806194, PMID:16607019]


id: GO:0043814
name: phospholactate guanylyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 2-phospho-(S)-lactate + GTP = lactyl-2-diphospho-5'-guanosine + diphosphate." [IMG:01547]


id: GO:0043815
name: phosphoribosylglycinamide formyltransferase 2 activity
namespace: molecular_function
def:
  "Catalysis of the reaction: formate + ATP + 5'-phospho-ribosylglycinamide = 5'-phosphoribosyl-N-formylglycinamide + ADP + diphosphate." [IMG:01297, PMID:8117714]


id: GO:0043816
name: phosphoserine-tRNA(Cys) ligase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: tRNA(Cys) + O-phospho-L-serine + ATP = AMP + diphosphate + phosphoseryl-tRNA(Cys)." [IMG:00622, PMID:17110438]


id: GO:0043817
name: phosphosulfolactate synthase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: (2R)-O-phospho-3-sulfolactate = phosphoenolpyruvate + sulfite." [EC:4.4.1.19, RHEA:22787]


id: GO:0043818
name: precorrin-3B synthase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: H(+) + NADH + O(2) + precorrin-3A = H(2)O + NAD(+) + precorrin-3B." [EC:1.14.13.83, RHEA:17296]


id: GO:0043819
name: precorrin-6A synthase (deacetylating) activity
namespace: molecular_function
def:
  "Catalysis of the reaction: S-adenosyl-L-methionine + H(2)O + precorrin-5 = S-adenosyl-L-homocysteine + acetate + 2 H(+) + precorrin-6X." [EC:2.1.1.152, RHEA:18264]


id: GO:0043820
name: propionyl-CoA dehydrogenase activity
namespace: molecular_function
def:
  "Catalysis of the irreversible NADH-dependent formation of propionyl-CoA from acryloyl-CoA." [PMID:12603323]


id: GO:0043821
name: propionyl-CoA:succinate CoA-transferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: succinate + propionyl-CoA = succinyl-CoA + propionate." [IMG:01589, MetaCyc:RXN0-268]


id: GO:0043822
name: ribonuclease M5 activity
namespace: molecular_function
def:
  "Catalysis of the endonucleolytic cleavage of RNA, removing 21 and 42 nucleotides, respectively, from the 5'- and 3'-termini of a 5S-rRNA precursor." [EC:3.1.26.8, IMG:02522]


id: GO:0043823
name: spheroidene monooxygenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: spheroidene + O2 = spheroidenone + H2O." [IMG:01761, MetaCyc:RXN-10670, PMID:16086104, PMID:16158287]


id: GO:0043824
name: succinylglutamate-semialdehyde dehydrogenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: N-succinyl-L-glutamate 5-semialdehyde + H(2)O + NAD(+) = N-succinyl-L-glutamate + 2 H(+) + NADH." [EC:1.2.1.71, RHEA:10815]


id: GO:0043825
name: succinylornithine transaminase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 2-oxoglutarate + N(2)-succinyl-L-ornithine = N-succinyl-L-glutamate 5-semialdehyde + L-glutamate." [EC:2.6.1.81, RHEA:16956]


id: GO:0043826
name: sulfur oxygenase reductase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 5 sulfur + oxygen + 4 H2O = sulfite + thiosulfate + 2 hydrogen sulfide + 9 H+." [IMG:00713, MetaCyc:RXN-8226, PMID:1522063]


id: GO:0043827
name: tRNA (adenine-57, 58-N(1)-) methyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the methylation of adenine-57 and adenine-58 in the T-loop of tRNA." [IMG:00706, PMID:14739239]


id: GO:0043828
name: tRNA 2-selenouridine synthase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 5-methylaminomethyl-2-thiouridine + selenophosphate = 5-methylaminomethyl-2-selenouridine + phosphate (at the wobble position in tRNA)." [IMG:02609, MetaCyc:RXN0-2281]


id: GO:0043829
name: tRNA-specific adenosine-37 deaminase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: adenosine-37 + H2O = inosine-37 + NH3, in a tRNA-Ala molecule." [IMG:00703, PMID:8915538, PMID:9707437]


id: GO:0043830
name: thiol-driven fumarate reductase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: fumarate + coenzyme M + coenzyme B = succinate + coenzyme M + coenzyme B + heterodisulfide." [IMG:01366, PMID:2509466]


id: GO:0043831
name: thiosulfate dehydrogenase (quinone) activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 6-decylubiquinone + 2 thiosulfate = 6-decylubiquinol + tetrathionate." [EC:1.8.5.2, RHEA:10939]


id: GO:0043833
name: methylamine-specific methylcobalamin:coenzyme M methyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: a methylated methylamine corrinoid protein + coenzyme M = a methylamine corrinoid protein + methyl-CoM. This reaction is the transfer of the methyl group from the methylated corrinoid cofactor of a methylamine corrinoid protein to coenzyme M." [IMG:01318, MetaCyc:RXN-8099]


id: GO:0043834
name: trimethylamine methyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: trimethylamine + a trimethylamine corrinoid protein = a methylated trimethylamine corrinoid protein + dimethylamine." [IMG:01323, MetaCyc:RXN-8102]


id: GO:0043835
name: obsolete uracil/thymine dehydrogenase activity
namespace: molecular_function
def:
  "OBSOLETE. Catalysis of the reactions: uracil + H2O + acceptor = barbiturate + reduced acceptor; and thymine + H2O + acceptor = 5-methylbarbiturate + reduced acceptor." [EC:1.17.99.4, IMG:01821]


id: GO:0043836
name: xanthine hydrolase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: xanthine + H2O = 4-ureido-5-imidazole carboxylate." [IMG:01834, MetaCyc:R127-RXN]


id: GO:0043837
name: valine dehydrogenase (NAD) activity
namespace: molecular_function
def:
  "Catalysis of the reaction: L-valine + H2O + NAD+ = 3-methyl-2-oxobutanoate + NH3 + NADH." [IMG:00766, PMID:10612726, PMID:2803248]


id: GO:0043838
name: phosphatidylethanolamine:Kdo2-lipid A phosphoethanolamine transferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: Kdo2-lipid A + phosphatidylethanolamine = phosphoethanolamine-Kdo2-lipid A + diacylglycerol." [IMG:00182, PMID:15795227]


id: GO:0043839
name: lipid A phosphate methyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the transfer of a methyl group from S-adenosylmethionine (SAM) to the 1-phosphate group of lipid A." [IMG:02094, PMID:15994324]


id: GO:0043840
name: branched-chain amino acid:2-keto-4-methylthiobutyrate aminotransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 2-keto-4-methylthiobutyrate + L-phenylalanine = phenylpyruvate + L-methionine." [IMG:01684, PMID:12670965]


id: GO:0043841
name: (S)-lactate 2-kinase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: (S)-lactate + GTP = 2-phospho-(S)-lactate + GDP." [IMG:01546, PMID:11535063]


id: GO:0043842
name: Kdo transferase activity
namespace: molecular_function
def:
  "Catalysis of the reactions: (KDO)-lipid IVA + CMP-3-deoxy-D-manno-octulosonate = KDO2-lipid IVA + CMP, and lipid IVA + CMP-3-deoxy-D-manno-octulosonate = (KDO)-lipid IVA + CMP." [IMG:00549, PMID:1577828, PMID:2033061, PMID:9195966]


id: GO:0043843
name: ADP-specific glucokinase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: ADP + D-glucose = AMP + D-glucose 6-phosphate." [EC:2.7.1.147, IMG:01468]


id: GO:0043844
name: ADP-specific phosphofructokinase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: ADP + D-fructose 6-phosphate = AMP + D-fructose 1,6-bisphosphate." [EC:2.7.1.146, IMG:01469]


id: GO:0043845
name: DNA polymerase III, proofreading complex
namespace: cellular_component
def:
  "A subcomplex of DNA polymerase III composed of the epsilon subunit which has proofreading activity, and the theta subunit which enhances the epsilon subunit's proofreading activity." [IMG:01721, PMID:16973612, Wikipedia:Pol_III]


id: GO:0043846
name: DNA polymerase III, clamp loader complex
namespace: cellular_component
def:
  "A heptamer that includes the tau and gamma products of the dnaX gene and the chi/psi subcomplex. Confers structural asymmetry that allows the polymerase to replicate both leading and lagging strands." [PMID:12940977]


id: GO:0043847
name: DNA polymerase III, clamp loader chi/psi subcomplex
namespace: cellular_component
def:
  "A dimer composed of the chi and psi subunits which is a subassembly of the DNA polymerase III clamp loader complex and serves as a bridge between the DnaX complex and the single-stranded DNA-binding protein (SSB)." [IMG:01719, PMID:12940977]


id: GO:0043848
name: excinuclease cho activity
namespace: molecular_function
def:
  "Catalysis of the incision of damaged DNA on the 3' side of a lesion, typically at the ninth phosphodiester bond 3' of the damage." [IMG:00499, PMID:11818552]


id: GO:0043849
name: Ras palmitoyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: palmitoyl-CoA + protein-cysteine = S-palmitoyl protein + CoA, specific for Ras proteins." [IMG:00473, PMID:16000296]


id: GO:0043850
name: RecFOR complex
namespace: cellular_component
def:
  "A heterotrimeric complex composed of the subunits RecF, RecO and RecR. Mediates the loading of RecA protein specifically onto SSB-coated gapped DNA during DNA repair." [IMG:01764, PMID:12769856]


id: GO:0043851
name: methanol-specific methylcobalamin:coenzyme M methyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: a methylated methanol corrinoid protein + coenzyme M = a methanol corrinoid protein + methyl-CoM. This reaction is the transfer of the methyl group from the methylated corrinoid cofactor of a methylamine corrinoid protein to coenzyme M." [IMG:01315, MetaCyc:RXN-8096]


