# go

id: GO:1990061
name: bacterial degradosome
namespace: cellular_component
def:
  "The degradosome is a protein complex playing a key role in mRNA degradation and RNA processing. It includes a RNA helicase, a 3'-5' phosphate-dependent PNPase and a RNase E bound-enolase." [GOC:bhm, PMID:21805185]


id: GO:1990062
name: RPAP3/R2TP/prefoldin-like complex
namespace: cellular_component
def:
  "A protein complex first characterized in human and comprised of a R2TP module (R2TP complex), a prefoldin-like module (containing both prefoldin-like proteins and canonical prefoldins), WD40 repeat protein Monad/WDR92 and DNA-dependent RNA polymerase subunit RPB5. This complex might have chaperone activity." [GOC:pr, PMID:20453924, PMID:21925213, PMID:22418846]


id: GO:1990063
name: Bam protein complex
namespace: cellular_component
def:
  "Protein complex which is involved in assembly and insertion of beta-barrel proteins into the outer membrane. In E. coli it is composed of BamABCDE, of the outer membrane protein BamA, and four lipoproteins BamB, BamC, BamD and BamE. BamA interacts directly with BamB and the BamCDE subcomplex." [GOC:bhm, PMID:20378773]


id: GO:1990064
name: ground tissue pattern formation
namespace: biological_process
def:
  "The regionalization process that gives rise to the patterning of the ground tissue." [PMID:23444357]


id: GO:1990065
name: Dxr protein complex
namespace: cellular_component
def:
  "A protein complex that is involved in the MEP pathway of IPP biosynthesis. It catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP)." [GOC:bhm, PMID:15339150]


id: GO:1990066
name: energy quenching
namespace: biological_process
def:
  "The process by which excess light energy absorbed by chlorophyll and not used to drive photosynthesis is emitted by nonphotochemical quenching or chlorophyll fluorescence." [PMID:10938857]


id: GO:1990069
name: stomatal opening
namespace: biological_process
def:
  "The process of opening of stomata, pores in the epidermis of leaves and stems bordered by two guard cells and serving in gas exchange." [PMID:21749899]


id: GO:1990070
name: TRAPPI protein complex
namespace: cellular_component
def:
  "A complex that tethers COPII vesicles at ER-Golgi intermediate compartment. Its role in this part of the vesicular transport may start at the ER exit sites. Binds to a component of the COPII coat. In yeast it includes the following subunits: Bet3 (as homodimer), Bet5, Trs20, Trs23, Trs31, Trs33 which are regarded as the \"core subunits\" of all TRAPP complexes in yeast." [GOC:bhm, PMID:20375281, PMID:22669257]


id: GO:1990071
name: TRAPPII protein complex
namespace: cellular_component
def:
  "A complex that mediates intra-Golgi traffic, Golgi exit, endosome-to-Golgi traffic, and the trafficking of autophagy proteins from Golgi to the pre-autophagosomal structure. Binds to a component of the COPI coat. In yeast it includes the following subunits: Bet3 (as homodimer), Bet5, Tca17, Trs20, Trs23, Trs31, Trs33, Trs65, Tr120, Tr130. The whole complex is thought to dimerize with itself." [GOC:bhm, PMID:20375281, PMID:22669257]


id: GO:1990072
name: TRAPPIII protein complex
namespace: cellular_component
def:
  "A complex that functions in anterograde transport at the Golgi and also regulates autophagy. In yeast it includes at least the following subunits: Bet3 (as homodimer), Bet5, Trs20, Trs23, Trs31, Trs33, Trs85. TRAPPIII may include further, as yet undescribed, proteins." [GOC:bhm, PMID:20375281, PMID:22669257]


id: GO:1990073
name: perforation plate
namespace: cellular_component
def:
  "A cell wall part that is the part of a wall of a vessel member and bears one or more openings (perforations)." [GOC:PO_curators, ISBN:0471245194]


id: GO:1990074
name: polyuridylation-dependent mRNA catabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the breakdown of a messenger RNA (mRNA) molecule, initiated by the enzymatic addition of a sequence of uridylyl residues (polyuridylation) at the 3' end of the target mRNA." [GOC:vw, PMID:23503588]


id: GO:1990075
name: periciliary membrane compartment
namespace: cellular_component
def:
  "A membrane domain at the base of cilia and flagella that is enriched in endocytosis-associated proteins and vesicles and that appears to function in regulating ciliary membrane homeostasis." [GOC:dr, PMID:22342749]


id: GO:1990076
name: cell wall polysaccharide catabolic process involved in abscission
namespace: biological_process
def:
  "Any cell wall polysaccharide catabolic process that is involved in abscission." [GOC:TermGenie, PMID:23479623]


id: GO:1990077
name: primosome complex
namespace: cellular_component
def:
  "Any of a family of protein complexes that form at the origin of replication or stalled replication forks and function in replication primer synthesis in all organisms.  Early complexes initiate double-stranded DNA unwinding. The core unit consists of a replicative helicase and a primase. The helicase further unwinds the DNA and recruits the polymerase machinery. The primase synthesizes RNA primers that act as templates for complementary stand replication by the polymerase machinery. The primosome contains a number of associated proteins and protein complexes and contributes to the processes of replication initiation, lagging strand elongation, and replication restart." [GOC:bhm, GOC:mah, PMID:21856207]


id: GO:1990078
name: replication inhibiting complex
namespace: cellular_component
def:
  "A protein complex that inhibits multiple events of replication initiation during one replication cycle." [GOC:bhm, PMID:21708944]


id: GO:1990079
name: cartilage homeostasis
namespace: biological_process
def:
  "A tissue homeostatic process involved in the maintenance of an internal equilibrium within cartilage, including control of cellular proliferation and death and control of metabolic function." [GOC:hjd, PMID:21652695]


id: GO:1990080
name: 2-phenylethylamine receptor activity
namespace: molecular_function
def:
  "Combining with the biogenic amine 2-phenylethylamine to initiate a change in cell activity." [PMID:16878137]


id: GO:1990081
name: trimethylamine receptor activity
namespace: molecular_function
def:
  "Combining with the biogenic amine trimethylamine to initiate a change in cell activity." [PMID:16878137]


id: GO:1990082
name: DnaA-L2 complex
namespace: cellular_component
def:
  "A protein complex that inhibits unwinding of DNA at the origin of replication and assembly of the pre-primosome. In E. coli, this complex is composed of DnaA and of the ribosomal protein L2." [GOC:bhm, PMID:21288885]


id: GO:1990083
name: DnaA-Hda complex
namespace: cellular_component
def:
  "A protein complex that inactivates the function of DnaA by inhibiting the phosphorylation of DnaA-ADP to DnaA-ATP and thereby preventing multiple events of replication initiation. In E. coli, this complex is composed of DnaA and Hda." [GOC:bhm, PMID:21708944]


id: GO:1990084
name: DnaA-Dps complex
namespace: cellular_component
def:
  "A protein complex that negatively regulates strand-opening at the origin of replication, thereby interfering with replication initiation. This complex is thought to be involved in the regulation of replication under oxidative stress conditions. In E. coli, this complex is composed of DnaA and Dps." [GOC:bhm, PMID:18284581]


id: GO:1990085
name: Hda-beta clamp complex
namespace: cellular_component
def:
  "A protein complex involved in inactivating the function of DnaA and thereby preventing multiple events of replication initiation. In E. coli, this complex is composed of the beta clamp (DnaN) and Hda." [GOC:bhm, PMID:15150238]


id: GO:1990086
name: lens fiber cell apoptotic process
namespace: biological_process
def:
  "Any apoptotic process in a lens fiber cell. Lens fiber cells are elongated, tightly packed cells that make up the bulk of the mature lens in a camera-type eye." [CL:0011004, GOC:hjd, PMID:11095619]


id: GO:1990088
name: [methyl-Co(III) methanol-specific corrinoid protein]:coenzyme M methyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: a [methyl-Co(III) methanol-specific corrinoid protein] + coenzyme M = methyl-CoM + a [Co(I) methanol-specific corrinoid protein]." [GOC:hjd, PMID:10077852]


id: GO:1990089
name: response to nerve growth factor
namespace: biological_process
def:
  "A process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nerve growth factor stimulus." [PMID:22399805]


id: GO:1990090
name: cellular response to nerve growth factor stimulus
namespace: biological_process
def:
  "A process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nerve growth factor stimulus." [PMID:22399805, Wikipedia:Nerve_growth_factor]


id: GO:1990091
name: sodium-dependent self proteolysis
namespace: biological_process
def:
  "The sodium-dependent hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their own peptide bonds." [PMID:20460380]


id: GO:1990093
name: obsolete negative regulation of N-methyl-D-aspartate receptor clustering
namespace: biological_process
def:
  "OBSOLETE. The negative regulation of the receptor clustering process in which N-methyl-D-aspartate (NMDA) receptors are localized to distinct domains in the cell membrane." [PMID:18442977]


id: GO:1990094
name: obsolete positive regulation of N-methyl-D-aspartate receptor clustering
namespace: biological_process
def:
  "OBSOLETE. The positive regulation of the receptor clustering process in which N-methyl-D-aspartate (NMDA) receptors are localized to distinct domains in the cell membrane." [PMID:18442977]


id: GO:1990095
namespace: biological_process
name:
  positive regulation of transcription from RNA polymerase II promoter in response to reactive oxygen species

def:
  "Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a reactive oxygen species stimulus. Reactive oxygen species include singlet oxygen, superoxide, and oxygen free radicals." [GOC:kmv, PMID:16166371]


id: GO:1990096
name: positive regulation of transcription from RNA polymerase II promoter in response to superoxide
namespace: biological_process
def:
  "Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a superoxide stimulus. Superoxide is the anion, oxygen-, formed by addition of one electron to dioxygen (O2) or any compound containing the superoxide anion." [GOC:kmv, PMID:12869585, PMID:16166371]


id: GO:1990097
name: SeqA-DNA complex
namespace: cellular_component
def:
  "A protein-DNA complex that contains an oligomer of SeqA bound to GATC sites in methylated or newly-synthesized, hemi-methylated double-stranded DNA, with preference for the latter. Binding of SeqA to hemimethylated DNA sequesters oriC, prevents re-methylation of DNA by Dam and in turn stops premature re-initiation of replication during one replication cycle." [GOC:bhm, PMID:12379844, PMID:15933720, PMID:23149570]


id: GO:1990098
name: core primosome complex
namespace: cellular_component
def:
  "A protein-DNA complex containing at least one DNA helicase and one primase. Can also contain associated proteins. The helicase component continues to unwind the double-stranded DNA (dsDNA) and the primase component synthesizes a RNA primer during initiation or restart of replication." [GOC:bhm, PMID:21856207]


id: GO:1990099
name: pre-primosome complex
namespace: cellular_component
def:
  "Any of the protein-DNA complexes that contain a DNA helicase and associated protein(s) at the origin of replication, and build up to assembling the core primosome. The associated protein(s) chaperone the helicase to the DNA, and assembly of the pre-primosome is essential for the initiation or restart of replication. Pre-primosome complexes lack a primase component." [GOC:bhm, PMID:18179598, PMID:20129058, PMID:8663105]


id: GO:1990100
name: DnaB-DnaC complex
namespace: cellular_component
def:
  "A protein complex containing homohexameric DNA helicase DnaB, and the DNA helicase loader DnaC. The helicase loader DnaC delivers DnaB to the chromosomal origin (oriC)." [GOC:bhm, PMID:20129058]


id: GO:1990101
name: DnaA-oriC complex
namespace: cellular_component
def:
  "A protein-DNA complex containing the initiator protein DnaA bound to high-affinity recognition sites in the unique origin of replication, oriC. DnaA-oriC binding is the first step in assembly of a bacterial pre-replicative complex (pre-RC) and is responsible for the timely initiation of replication once per cell cycle." [GOC:bhm, PMID:19833870]


id: GO:1990102
name: DnaA-DiaA complex
namespace: cellular_component
def:
  "A protein-DNA complex containing a tetramer of DiaA attached to multiple  DnaA molecule bound to oriC DNA. Regulates timely initiation of chromosomal replication during the cell cycle by stimulating assembly of DnaA-oriC complexes, conformational changes in ATP-DnaA initiation complexes, and unwinding of oriC duplex DNA." [GOC:bhm, PMID:15326179, PMID:17699754]


id: GO:1990103
name: DnaA-HU complex
namespace: cellular_component
def:
  "A protein-DNA complex containing DNA-bound DnaA attached to HU. HU is a dimer encoded by two closely related genes. Essential for the initiation of replication in bacteria; stimulates the DnaA-dependent unwinding of oriC." [GOC:bhm, PMID:18179598]


id: GO:1990104
name: DNA bending complex
namespace: cellular_component
def:
  "A protein-DNA complex that contains DNA in combination with a protein which binds to and bends DNA. Often plays a role in DNA compaction." [GOC:bhm, PMID:17097674]


id: GO:1990105
name: obsolete regulation of voltage-gated potassium channel activity
namespace: biological_process
def:
  "OBSOLETE. Any process that modulates the frequency, rate or extent of voltage-gated potassium channel activity." [PMID:19219384]


id: GO:1990107
name: thiazole synthase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 1-deoxy-D-xylulose 5-phosphate + 2-iminoacetate + thiocarboxy-adenylate-[sulfur-carrier protein ThiS] = 2-[(2R,5Z)-2-carboxy-4-methylthiazol-5(2H)-ylidene]ethyl phosphate + [sulfur-carrier protein ThiS] + 2 H2O." [EC:2.8.1.10, GOC:cjk, PMID:22031445, RHEA:26300]


id: GO:1990108
name: protein linear deubiquitination
namespace: biological_process
def:
  "A protein deubiquitination process in which a linear polymer of ubiquitin, formed by the amino-terminal methionine (M1) of one ubiquitin molecule and by the carboxy-terminal glycine (G76) of the next, is removed from a protein." [PMID:23708998]


id: GO:1990109
name: rejection of pollen from other species
namespace: biological_process
def:
  "The process involved in the rejection of pollen of one species by cells in the stigma of another species." [PMID:21205670]


id: GO:1990110
name: callus formation
namespace: biological_process
def:
  "The process by which a callus is formed at a wound site. A plant callus is a portion of plant tissue that consists of mass of undifferentiated plant cells. It consists primarily of parenchyma cells but possibly contains other cell types as the callus begins to differentiate." [ISBN:0070187517]


id: GO:1990111
name: spermatoproteasome complex
namespace: cellular_component
def:
  "A proteasome specifically found in mammalian testis. Contains the proteasome activator PA200 in the regulatory particle, and beta1i, beta2i, beta5i and/or alpha4s in the core (20S) subunit. Beta1i, beta2i and beta5i are inducible catalytic subunits, closely related to beta1, beta2 and beta5. Alpha4s is a sperm-specific 20S subunit, but unlike other alternative 20S subunits alpha4s lies in the outer alpha-ring and lacks catalytic activity." [GOC:sp, PMID:23706739]


id: GO:1990112
name: RQC complex
namespace: cellular_component
def:
  "A multiprotein complex that forms a stable complex with 60S ribosomal subunits containing stalled polypeptides and triggers their degradation (ribosomal quality control). In budding yeast, this complex includes Cdc48p, Rkr1p, Tae2p, Rqc1p, Npl4p and Ufd1p proteins." [GOC:rb, PMID:23178123, PMID:23232563]


id: GO:1990113
name: RNA Polymerase I assembly
namespace: biological_process
def:
  "The aggregation, arrangement and bonding together of a set of components to form the eukaryotic RNA polymerase I complex." [GOC:rb, PMID:23459708]


id: GO:1990114
name: RNA Polymerase II core complex assembly
namespace: biological_process
def:
  "The aggregation, arrangement and bonding together of a set of components to form the eukaryotic RNA polymerase II core complex." [GOC:rb, PMID:23459708]


id: GO:1990115
name: RNA Polymerase III assembly
namespace: biological_process
def:
  "The aggregation, arrangement and bonding together of a set of components to form the eukaryotic RNA polymerase III complex." [GOC:rb, PMID:23459708]


id: GO:1990116
name: ribosome-associated ubiquitin-dependent protein catabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the breakdown of a protein or peptide encoded by an aberrant message and associated with a stalled ribosome. Degradation is initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the ribosome-associated protein." [GOC:dgf, PMID:23358411]


id: GO:1990117
name: B cell receptor apoptotic signaling pathway
namespace: biological_process
def:
  "An extrinsic apoptotic signaling pathway initiated by the cross-linking of an antigen receptor on a B cell." [GOC:BHF, GOC:mtg_apoptosis, GOC:rl, PMID:15214043]


id: GO:1990118
name: sodium ion import into cell
namespace: biological_process
def:
  "The directed movement of sodium ions from outside of a cell into the intracellular region of a cell." [GOC:al, PMID:14674689]


id: GO:1990120
name: messenger ribonucleoprotein complex assembly
namespace: biological_process
def:
  "The aggregation, arrangement and bonding together of proteins and messenger RNA (mRNA) molecules to form a messenger ribonucleoprotein (mRNP) complex." [GOC:rb, PMID:23721653]


id: GO:1990121
name: H-NS complex
namespace: cellular_component
def:
  "A multimer of H-NS proteins that is involved in bacterial nucleoid condensation and negative regulation of global gene expression by directly binding to promoter regions. Recognizes both structural and sequence-specific motifs in double-stranded DNA and has binding preference for bent DNA." [GOC:bhm, PMID:12592399]


id: GO:1990122
name: leucine import into cell
namespace: biological_process
def:
  "The directed movement of leucine from outside of a cell into the cytoplasmic compartment. This may occur via transport across the plasma membrane or via endocytosis." [GOC:mah, PMID:1356078]


id: GO:1990123
name: L-glutamate import into cell
namespace: biological_process
def:
  "The directed movement of L-glutamate from outside of a cell into the cytoplasmic compartment. This may occur via transport across the plasma membrane or via endocytosis." [GOC:mah, PMID:1356078]


id: GO:1990124
name: messenger ribonucleoprotein complex
namespace: cellular_component
def:
  "A ribonucleoprotein complex containing both protein and messenger RNA (mRNA) molecules." [GOC:bf, PMID:15574591, PMID:21915786]


id: GO:1990125
name: DiaA complex
namespace: cellular_component
def:
  "A homotetrameric protein complex consisting of a symmetrical pair of DiaA homodimers. Facilitates DnaA binding to the origin of replication during replication initiation." [GOC:bhm, PMID:17699754]


id: GO:1990126
name: retrograde transport, endosome to plasma membrane
namespace: biological_process
def:
  "The directed movement of membrane-bounded vesicles from endosomes back to the plasma membrane, a trafficking pathway that promotes the recycling of internalized transmembrane proteins." [PMID:23563491]


id: GO:1990127
name: intrinsic apoptotic signaling pathway in response to osmotic stress by p53 class mediator
namespace: biological_process
def:
  "A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of osmotic stress, and ends when the execution phase of apoptosis is triggered." [GOC:krc, GOC:mtg_apoptosis, PMID:16571598]


id: GO:1990128
name: obsolete pre-primosome complex involved in replication initiation
namespace: cellular_component
def:
  "OBSOLETE. A protein-DNA complex involved in replication initiation at the origin of replication." [GOC:bhm, PMID:21856207]


id: GO:1990129
name: obsolete pre-primosome complex involved in replication restart
namespace: cellular_component
def:
  "OBSOLETE. A protein-DNA complex involved in replication restart after a stalled replication fork has been repaired." [GOC:bhm, PMID:17139333]


id: GO:1990130
name: Iml1 complex
namespace: cellular_component
def:
  "A protein complex involved in regulation of non-nitrogen-starvation (NNS) autophagic process. In S. cerevisiae this complex contains Iml1p, Npr2p and Npr3p proteins. In humans the GATOR1 complex consists of DEPDC5, Nprl2, Nprl3." [GOC:rb, PMID:21900499, PMID:23974112]


id: GO:1990131
name: Gtr1-Gtr2 GTPase complex
namespace: cellular_component
def:
  "A heterodimer GTPase complex. In S. cerevisiae, this complex contains Gtr1p and Gtr2p proteins." [GOC:rb, PMID:10388807, PMID:16143306]


id: GO:1990132
name: obsolete release of misfolded protein from chaperone
namespace: biological_process
def:
  "OBSOLETE. The release of misfolded proteins that are being held by the chaperone heat shock protein (Hsp) and targeting them for destruction by the Ub-proteasome machinery." [GOC:rb, PMID:23530227]


id: GO:1990133
name: molybdopterin cofactor (Moco) biosynthesis adenylyltransferase complex
namespace: cellular_component
def:
  "A heterodimeric protein complex which adenylates two molecules of the sulfur carrier subunit of the molybdopterin (MPT) cofactor synthase using ATP as part of molybdopterin cofactor (Moco) biosynthesis. In E. coli the subunits are MoeB and MoaD; Moco biosynthesis and its constituent molecules are evolutionarily conserved." [GOC:bhm, pmid:11713534, pmid:16669776]


id: GO:1990134
name: epithelial cell apoptotic process involved in palatal shelf morphogenesis
namespace: biological_process
def:
  "An apoptotic process in a palatal shelf epithelial cell that contributes to the shaping of the palatal shelf." [GOC:dph, GOC:mtg_apoptosis, PMID:16607638]


id: GO:1990135
name: flavonoid sulfotransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: a flavonoid + 3'-phosphoadenosine-5'-phosphosulfate = sulfated flavonoid + adenosine-3',5'-diphosphate. This reaction is the transfer of a sulfate group to the hydroxyl group of a flavonoid acceptor, producing the sulfated flavonoid derivative." [PMID:23611783]


id: GO:1990136
name: linoleate 9S-lipoxygenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: linoleate + O2 = (9S,10E,12Z)-9-hydroperoxy-10,12-octadecadienoate." [EC:1.13.11.58, GOC:rph, RHEA:30294]


id: GO:1990138
name: neuron projection extension
namespace: biological_process
def:
  "Long distance growth of a single neuron projection involved in cellular development. A neuron projection is a prolongation or process extending from a nerve cell, e.g. an axon or dendrite." [GOC:BHF, GOC:rl, PMID:22790009]


id: GO:1990139
name: protein localization to nuclear periphery
namespace: biological_process
def:
  "A process in which a protein is transported to, or maintained in, a location within the nuclear periphery." [GOC:mah, PMID:23703609]


id: GO:1990140
name: MPT synthase complex
namespace: cellular_component
def:
  "A heterodimeric protein complex which catalyses sulfur transfer from the sulfur carrier subunit of MPT synthase to precursor Z to synthesize MPT as part of molybdopterin cofactor (Moco) biosynthesis. In E. coli the subunits are MoaE and MoaD; in human, MOCS2B and MOCS2A. Moco biosynthesis and its constituent molecules are evolutionarily conserved." [GOC:bhm, PMID:11135669, PMID:16669776, Reactome:REACT_25073.1]


id: GO:1990141
name: chromatin silencing at centromere outer repeat region
namespace: biological_process
def:
  "Repression of transcription of DNA at the outer repeat region of a regional centromere by altering the structure of chromatin." [PMID:21847092]


id: GO:1990142
name: envenomation resulting in hemolysis in other organism
namespace: biological_process
def:
  "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with hemolysis in the bitten organism." [PMID:21590705]


id: GO:1990143
name: CoA-synthesizing protein complex
namespace: cellular_component
def:
  "A multisubunit complex likely involved in the synthesis of coenzyme A (CoA). In S. cerevisiae, the complex is formed by Cab2, Cab3, Cab4, Cab5, Sis2 and Vhs3." [GOC:rb, PMID:23789928]


id: GO:1990144
name: intrinsic apoptotic signaling pathway in response to hypoxia
namespace: biological_process
def:
  "A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced in response to hypoxia (lowered oxygen tension). Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level. The pathway ends when the execution phase of apoptosis is triggered." [GOC:BHF, GOC:mtg_apoptosis, GOC:rl, PMID:20436456]


id: GO:1990145
name: maintenance of translational fidelity
namespace: biological_process
def:
  "Suppression of the occurrence of translational errors, such as codon-anticodon mis-paring, during the process of translation of a protein using an mRNA template." [GOC:hjd, ISBN:9781936113460, PMID:21841312]


id: GO:1990146
name: protein localization to rhabdomere
namespace: biological_process
def:
  "A process in which a protein is transported to, or maintained in, a location within a rhabdomere." [GOC:sart, PMID:8335687]


id: GO:1990147
name: talin binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with a talin, a family of related cytoskeletal proteins that play a role in assembly of actin filaments and migration of various cell types." [GOC:hjd, PMID:23372168]


id: GO:1990148
name: glutamate dehydrogenase complex
namespace: cellular_component
def:
  "A homomeric protein complex that possesses glutamate dehydrogenase activity. This complex is evolutionarily conserved except that the number of homoprotomers per complex varies." [GOC:bhm, PMID:22393408, PMID:23412807]


id: GO:1990149
name: obsolete COPI vesicle coating
namespace: biological_process
def:
  "OBSOLETE. The addition of COPI proteins and adaptor proteins to ER membranes during the formation of transport vesicles, forming a vesicle coat." [GOC:rb, PMID:11970962]


id: GO:1990150
name: VEGF-A complex
namespace: cellular_component
def:
  "A homodimeric, extracellular protein complex containing two VEGF-A monomers. Binds to and activates a receptor tyrosine kinase." [GOC:bf, GOC:bhm, PMID:12207021, PMID:19658168]


id: GO:1990151
name: protein localization to cell tip
namespace: biological_process
def:
  "A process in which a protein is transported to, or maintained in, a location at the cell tip." [PMID:22768263]


id: GO:1990152
name: protein localization to telomeric heterochromatin
namespace: biological_process
def:
  "A process in which a protein is transported to, or maintained in, a location in telomeric heterochromatin." [PMID:21300781]


id: GO:1990153
name: maintenance of protein localization to heterochromatin
namespace: biological_process
def:
  "A process in which a protein is maintained in a location in telomeric heterochromatin." [PMID:21300781]


id: GO:1990154
name: enzyme IIA-maltose transporter complex
namespace: cellular_component
def:
  "A protein complex consisting of the pentameric maltose transporter complex bound to two enzyme IIA (EIIA) molecules. EIIA is a component of the glucose-specific phosphotransferase system that inhibits maltose transport from the periplasm to the cytoplasm. When EIIA-bound, the maltose transporter remains in the open, inward-facing conformation, which prevents binding of maltose-loaded maltose binding protein (MBP) to the transporter." [GOC:bf, GOC:bhm, PMID:23770568]


id: GO:1990155
name: Dsc E3 ubiquitin ligase complex assembly
namespace: biological_process
def:
  "The aggregation, arrangement and bonding together of a set of components to form a Dsc E3 ubiquitin ligase complex, an E3 ubiquitin ligase complex localized to the ER and Golgi membrane." [GOC:mah, PMID:23760507]


id: GO:1990156
name: DnaB-DnaG complex
namespace: cellular_component
def:
  "A protein complex containing homohexameric DnaB helicase, and DnaG (a primase). Facilitates the unwinding of double-stranded DNA and the synthesis of RNA primer sequences during DNA replication and repair in Prokaryotes." [GOC:bhm, PMID:14557266]


id: GO:1990157
name: DnaA-DnaB-DnaC complex
namespace: cellular_component
def:
  "A protein-DNA complex consisting of the helicase loading complex DnaB-DnaC bound to the DNA-bound DNA replication initiation protein DnaA. Essential for DNA replication initiation." [GOC:bhm, PMID:20129058]


id: GO:1990158
name: DnaB-DnaC-DnaT-PriA-PriB complex
namespace: cellular_component
def:
  "A protein-DNA complex consisting of the helicase loading complex DnaB-DnaC, replication restart proteins DnaT, PriA and PriB, and associated DNA. Involved in the restart of DNA replication after a stalled replication fork has been repaired." [GOC:bhm, PMID:8663105]


id: GO:1990159
name: DnaB-DnaC-DnaT-PriA-PriC complex
namespace: cellular_component
def:
  "A protein-DNA complex consisting of the helicase loading complex DnaB-DnaC, replication restart proteins DnaT, PriA and PriC, and associated DNA. Involved in the restart of DNA replication after a stalled replication fork has been repaired." [GOC:bhm, PMID:8663105]


id: GO:1990160
name: DnaB-DnaC-Rep-PriC complex
namespace: cellular_component
def:
  "A protein-DNA complex consisting of the helicase loading complex DnaB-DnaC, replication restart proteins Rep and PriC, and associated DNA. Involved in the restart of DNA replication after a stalled replication fork has been repaired." [GOC:bhm, PMID:19941825, PMID:8663105]


id: GO:1990161
name: DnaB helicase complex
namespace: cellular_component
def:
  "A homohexameric protein complex that possesses DNA helicase activity; functions during DNA replication and repair." [GOC:bhm, PMID:17947583]


id: GO:1990162
name: histone deacetylase activity (H3-K4 specific)
namespace: molecular_function
def:
  "Catalysis of the reaction: histone H3 N6-acetyl-L-lysine (position 4) + H2O = histone H3 L-lysine (position 4) + acetate. This reaction represents the removal of an acetyl group from lysine at position 4 of the histone H3 protein." [GOC:al, PMID:23771057]


id: GO:1990163
name: ATP-dependent four-way junction helicase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: ATP + H2O = ADP + phosphate, where this reaction drives the unwinding of the DNA helix of DNA containing four-way junctions, including Holliday junctions." [GOC:al, PMID:22723423]


id: GO:1990165
name: single-strand break-containing DNA binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with damaged DNA containing single-strand breaks (SSBs)." [GOC:al, PMID:21984210]


id: GO:1990166
name: protein localization to site of double-strand break
namespace: biological_process
def:
  "Any process in which a protein is transported to, or maintained at, a region of a chromosome at which a DNA double-strand break has occurred." [GOC:mah, PMID:23080121]


id: GO:1990167
name: protein K27-linked deubiquitination
namespace: biological_process
def:
  "A protein deubiquitination process in which a K27-linked ubiquitin chain, i.e. a polymer of ubiquitin formed by linkages between lysine residues at position 27 of the ubiquitin monomers, is removed from a protein." [PMID:23827681]


id: GO:1990168
name: protein K33-linked deubiquitination
namespace: biological_process
def:
  "A protein deubiquitination process in which a K33-linked ubiquitin chain, i.e. a polymer of ubiquitin formed by linkages between lysine residues at position 33 of the ubiquitin monomers, is removed from a protein." [PMID:23827681]


id: GO:1990169
name: stress response to copper ion
namespace: biological_process
def:
  "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis caused by a copper ion stimulus." [GOC:kmv, PMID:23437011]


id: GO:1990170
name: stress response to cadmium ion
namespace: biological_process
def:
  "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis caused by a cadmium ion stimulus." [GOC:kmv]


id: GO:1990171
name: SCF complex disassembly in response to cadmium stress
namespace: biological_process
def:
  "The disaggregation of the SCF ubiquitin ligase complex in response to cadmium stress." [GOC:rb, PMID:23000173]


id: GO:1990172
name: G-protein coupled receptor catabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the breakdown of a G-protein coupled receptor." [PMID:12142540, PMID:23954414]


id: GO:1990173
name: protein localization to nucleoplasm
namespace: biological_process
def:
  "A process in which a protein is transported to, or maintained in, a location within the nucleoplasm." [GOC:mah, PMID:22918952]


id: GO:1990174
name: phosphodiesterase decapping endonuclease activity
namespace: molecular_function
def:
  "Catalysis of the removal of the cap from an unmethylated 5'-end capped RNA resulting in the release of the entire cap structure (GpppN) and a 5' monophosphorylated RNA." [GOC:dgf, PMID:20802481]


id: GO:1990175
name: EH domain binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with an EH domain of a protein. The EH stand for Eps15 homology. This was originally identified as a motif present in three copies at the NH2-termini of Eps15 and of the related molecule Eps15R." [GOC:hjd, PMID:11911876, PMID:21115825]


id: GO:1990176
name: MalFGK2 complex
namespace: cellular_component
def:
  "Protein complex involved in maltose transport through the plasma membrane. In E. coli, the complex is a tetramer and consists of a cytoplasmic ATPase MalK homodimer together with a heterodimeric transmembrane subunit MalF-MalG." [GOC:bhm, PMID:19250913]


id: GO:1990177
name: IHF-DNA complex
namespace: cellular_component
def:
  "A protein-DNA complex containing IHF heterodimers (an alpha and a beta chain) bound to DNA. IHF binds to double-stranded DNA in a structure- and sequence-specific manner and bends the DNA into a nucleosome-like structure, the bacterial nucleoid." [GOC:bhm, PMID:17097674]


id: GO:1990178
name: HU-DNA complex
namespace: cellular_component
def:
  "A protein-DNA complex that consists of HU heterodimers (an alpha and a beta chain) assembled into octamers along DNA. HU binds to double-stranded DNA in a structure- and sequence-specific manner and bends the DNA into a nucleosome-like structure." [GOC:bhm, PMID:17360520]


id: GO:1990179
name: protein localization to actomyosin contractile ring
namespace: biological_process
def:
  "A process in which a protein is transported to, or maintained at, the actomyosin contractile ring." [GOC:mah, PMID:23349808]


id: GO:1990180
name: mitochondrial tRNA 3'-end processing
namespace: biological_process
def:
  "The process in which the 3' end of a pre-tRNA molecule is converted to that of a mature tRNA in the mitochondrion." [GOC:mah, GOC:TermGenie, PMID:23928301]


id: GO:1990181
name: acetyl-CoA biosynthetic process from pantothenate
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of acetyl-CoA from pantothenate via phosphopantothenate and CoA." [GOC:mah, PMID:23091701]


id: GO:1990182
name: exosomal secretion
namespace: biological_process
def:
  "The process whereby a membrane-bounded vesicle are released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane." [GOC:hjd, PMID:18617898]


id: GO:1990184
name: amino acid transport complex
namespace: cellular_component
def:
  "A heteromeric protein complex consisting of a multi-transmembrane spanning subunit (the light chain) and a type II glycoprotein subunit (the heavy chain) that functions to transport amino acids across a plasma membrane." [GOC:kmv, PMID:14668347]


id: GO:1990185
name: regulation of lymphatic vascular permeability
namespace: biological_process
def:
  "Any process that modulates the extent to which lymphatic vessels can be pervaded by fluid." [PMID:23897233]


id: GO:1990187
name: obsolete protein localization to mRNA
namespace: biological_process
def:
  "OBSOLETE. A process in which a protein is transported to, or maintained at mRNA." [GOC:rb, PMID:22890846]


id: GO:1990188
name: euchromatin binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with euchromatin, a dispersed and relatively uncompacted form of chromatin." [GOC:vw, PMID:22431512]


id: GO:1990189
name: peptide-serine-N-acetyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: acetyl-CoA + N-terminal L-serine in peptide = CoA + N-acetyl-L-serine-peptide." [GOC:al, PMID:23912279]


id: GO:1990190
name: peptide-glutamate-N-acetyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: acetyl-CoA + N-terminal L-glutamate in peptide = CoA + N-acetyl-L-glutamate-peptide." [GOC:al, PMID:23912279]


id: GO:1990191
name: cobalamin transport complex
namespace: cellular_component
def:
  "Protein complex facilitating ATP-dependent cobalamin (vitamin B12) transport through inner cell membrane (periplasm to cytoplasm) in Gram-negative bacteria. In E. coli the system is composed of a periplasmic cobalamin-binding protein (BtuF), an integral membrane homodimer, BtuC, and a cytoplasmic ATP-binding homodimer BtuD." [GOC:bhm, PMID:22569249]


id: GO:1990193
name: BtuCD complex
namespace: cellular_component
def:
  "Protein complex involved in cobalamin (vitamin B12) transport through the plasma membrane. In E. coli, the complex is a tetramer and consists of the cytoplasmic ATPase BtuD homodimer together with the transmembrane BtuC homodimer." [GOC:bhm, PMID:22569249]


id: GO:1990194
name: cytoplasmic U snRNP body assembly
namespace: biological_process
def:
  "The aggregation, arrangement and bonding together of proteins and RNA molecules to form a cytoplasmic U snRNP body." [PMID:19464282]


id: GO:1990195
name: macrolide transmembrane transporter complex
namespace: cellular_component
def:
  "A bacterial transmembrane transporter complex that spans the entire cell membrane system and possesses ATP-dependent xenobiotic transport activity pumping drugs (typically antibiotics) and other toxins directly from the cytosol out of the bacterial cell. Typically, it is trimeric consisting of a inner membrane ATPase (IMP), a periplasmic membrane fusion protein (MFP) and an outer membrane factor (OMF). In E. coli, macrolide transporter complexes may consists of MacB (IMP), MacA (MFP) and TolC (OMF) or AcrB (IMP), AcrA (MFP) and TolC (OMF). Trimeric TolC is a common OMF found in many macrolide transporter complexes." [GOC:bhm, PMID:10879525, PMID:18955484, PMID:19254725]


id: GO:1990196
name: MacAB-TolC complex
namespace: cellular_component
def:
  "The MacAB-TolC complex is a macrolide transporter complex found in E.coli and related gram-negative bacteria. Its transport activity is specific to macrolide compounds containing 14- and 15-membered lactones. It consists of the dimeric inner membrane ATPase MacB, the hexameric, periplasmic membrane fusion protein MacA and the trimeric outer membrane factor TolC." [GOC:bhm, PMID:10879525, PMID:18955484, PMID:19254725]


id: GO:1990197
name: ATP-dependent methionine-importing complex
namespace: cellular_component
def:
  "An ATP-binding cassette (ABC) transporter complex that is capable of methionine-importing activity. An example is the bacterial MetNIQ methionine transporter, that consists of the dimeric ATPase subunit MetN located at the cytoplasmic side of the plasma membrane and the dimeric transmembrane subunit MetI. MetQ is regarded as the periplasmic methionine-binding chaperon subunit, and is capable of transporting methionine from the periplasm into the cytoplasm in an ATP-dependent manner." [GOC:bhm, PMID:22095702]


id: GO:1990198
name: ModE complex
namespace: cellular_component
def:
  "A dimeric protein complex containing two ModE subunits. Binds directly to DNA to regulate transcription, and is involved in (positively and negatively) regulating various aspects of molybdenum metabolism." [GOC:bhm, PMID:12581638]


id: GO:1990199
name: MsbA transporter complex
namespace: cellular_component
def:
  "An ATP-binding cassette (ABC) transporter complex made up of a dimer of MsbA. Facilitates the export across the plasma membrane of, amongst others, lipid A and lipopolysaccharide. In contrast to most ABC transporter complexes, each chain of the homodimer contains both the transmembrane domain (TMD) and the cytoplasmic ATP-binding domain (NBD)." [GOC:bhm, PMID:18024585]


id: GO:1990200
name: SsuD-SsuE complex
namespace: cellular_component
def:
  "A protein complex containing an alkanesulfonate monooxygenase subunit (SsuD tetramer in E.coli) and a flavin oxidoreductase subunit (SsuE dimer in E.coli). Involved in the utilization of alkanesulfonates as sulfur sources under conditions of sulfate or cysteine starvation." [GOC:bhm, PMID:16997955]


id: GO:1990201
name: alkanesulfonate monooxygenase complex
namespace: cellular_component
def:
  "A protein complex capable of alkanesulfonate monooxygenase activity. Involved in the utilization of alkanesulfonates as sulfur sources under conditions of sulfate or cysteine starvation, catalyzing the conversion of alkanesulfonates into aldehydes and sulfite. In E.coli the complex consists of a SsuD tetramer." [GOC:bhm, PMID:10480865, PMID:16997955]


id: GO:1990202
name: FMN reductase complex
namespace: cellular_component
def:
  "A protein complex capable of FMN reductase activity. Reduces FMN to FMNH2 in a NAD(P)H-dependent manner. In E.coli, consists of a SsuE dimer." [GOC:bhm, PMID:10480865, PMID:16997955]


id: GO:1990203
name: MdtBC Complex
namespace: cellular_component
def:
  "A protein complex containing two transmembrane subunits; a MdtB dimer and one unit of MdtC. Capable of exporting substrates across the cell membrane. Involved in conferring antibiotic resistance of Gram-negative bacteria by transporting drugs across the membrane." [GOC:bhm, PMID:20038594]


id: GO:1990205
name: taurine dioxygenase complex
namespace: cellular_component
def:
  "A protein complex capable of catalyzing the conversion of taurine and alpha-ketoglutarate to sulfite, aminoacetaldehyde and succinate under sulfur or cysteine starvation conditions. Its expression is repressed by the presence of sulfate or cysteine. In E. coli it is a homodimer or homotetramer of the protein TauD." [GOC:bhm, PMID:12741810]


id: GO:1990207
name: EmrE multidrug transporter complex
namespace: cellular_component
def:
  "A transmembrane protein complex capable of transporting positively charged hydrophobic drugs across the plasma membrane thereby involved in conferring resistance to a wide range of toxic compounds (e.g. methyl viologen, ethidium bromide and acriflavine). It is commonly found in bacteria. In E. coli it forms a homodimer." [GOC:bhm, PMID:18024586]


id: GO:1990208
name: positive regulation by symbiont of RNA levels in host
namespace: biological_process
def:
  "Any process in which an organism activates, maintains or increases the frequency, rate or extent of the RNA levels in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [PMID:12182338, PMID:18703740]


id: GO:1990209
name: negative regulation by symbiont of RNA levels in host
namespace: biological_process
def:
  "Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of the RNA levels in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:ml, PMID:18703740]


id: GO:1990210
name: positive regulation by symbiont of indole acetic acid levels in host
namespace: biological_process
def:
  "Any process in which an organism activates, maintains or increases the frequency, rate or extent of the indole acetic acid levels in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:ml, PMID:18056646]


id: GO:1990211
name: positive regulation by symbiont of jasmonic acid levels in host
namespace: biological_process
def:
  "Any process in which an organism activates, maintains or increases the frequency, rate or extent of the jasmonic acid levels in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:ml, PMID:14617079, PMID:16553894]


id: GO:1990212
name: positive regulation by symbiont of ethylene levels in host
namespace: biological_process
def:
  "Any process in which an organism activates, maintains or increases the frequency, rate or extent of the ethylene levels in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:ml, PMID:16167902]


id: GO:1990213
name: negative regulation by symbiont of salicylic acid levels in host
namespace: biological_process
def:
  "Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of salicylic acid levels in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:ml, PMID:17722699, PMID:20565685]


id: GO:1990214
name: negative regulation by symbiont of host protein levels
namespace: biological_process
def:
  "Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of protein levels in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [PMID:16840699, PMID:22233353]


id: GO:1990215
name: negative regulation by symbiont of host intracellular transport
namespace: biological_process
def:
  "Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of intracellular transport in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [PMID:22319451]


id: GO:1990216
name: positive regulation by symbiont of host transcription
namespace: biological_process
def:
  "Any process in which an organism activates, maintains or increases the frequency, rate or extent of transcription in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [PMID:21994350]


id: GO:1990217
name: negative regulation by symbiont of host phytoalexin production
namespace: biological_process
def:
  "Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of phytoalexin production in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [PMID:21402357]


id: GO:1990218
name: positive regulation by symbiont of abscisic acid levels in host
namespace: biological_process
def:
  "Any process in which an organism activates, maintains or increases the frequency, rate or extent of the abscisic acid levels in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [PMID:17304219]


id: GO:1990219
name: positive regulation by symbiont of host protein levels
namespace: biological_process
def:
  "Any process in which an organism activates, maintains or increases the frequency, rate or extent of protein levels in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [PMID:20615948]


id: GO:1990220
name: GroEL-GroES complex
namespace: cellular_component
def:
  "Bacterial chaperonin complex consisting of a heptameric 10kDa chaperonin subunit GroES and a tetradecameric (2x7) 60kDa chaperonin subunit GroEL. The 60kDa subunit possesses ATPase activity while the holo-enzyme is responsible for the correct folding of proteins." [GOC:bhm, PMID:15313620]


id: GO:1990221
name: L-cysteine desulfurase complex
namespace: cellular_component
def:
  "A protein complex capable of cysteine desulfurase activity decomposing L-cysteine to L-alanine and sulfur. It belongs to a ubiquitous family of pyridoxal 5-phosphate (PLP)-dependent enzymes. In E. coli it consists of a SufS dimer." [GOC:bhm, PMID:11827487]


id: GO:1990222
name: ProVWX complex
namespace: cellular_component
def:
  "The ProVWX complex belongs to the family of ATP-binding cassette (ABC) transporter proteins complexes. It consists of a cytoplasmic ATPase subunit ProV, a transmembrane subunit ProW and a periplasmic binding protein ProX. It is capable of translocating a wide variety of solute (e.g. glycine betaine) across the plasma membrane and is activated under osmotic stress conditions." [GOC:bhm, PMID:23249124]


id: GO:1990223
name: positive regulation by symbiont of cytokinin levels in host
namespace: biological_process
def:
  "Any process in which an organism activates, maintains or increases the frequency, rate or extent of the cytokinin levels in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [PMID:24124900]


id: GO:1990224
name: NMN phosphatase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: beta-nicotinamide D-ribonucleotide (NMN-) + H2O = beta-nicotinamide D-riboside (nicotinamide ribose, NmR) + phosphate." [GOC:rb, PMID:21349851, RHEA:30818]


id: GO:1990225
name: rhoptry neck
namespace: cellular_component
def:
  "Narrow, electron-dense part of the rhoptry that extends through the conoid at the apical tip of an apicomplexan parasite. The rhoptry neck serves as a duct through which the contents of the rhoptry are secreted after attachment to the host has been completed and at the commencement of invasion." [GOC:giardia, GOC:pr, PMID:23499754, PMID:23937520, PMID:24002067, PMID:24070999]


id: GO:1990226
name: histone methyltransferase binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with a histone methyltransferase enzyme." [GOC:ame, GOC:BHF, PMID:19486527]


id: GO:1990227
name: paranodal junction maintenance
namespace: biological_process
def:
  "The maintenance of a paranodal junction, a highly specialized cell-cell junction found in vertebrates, which forms between a neuron and a glial cell, and has structural similarity to Drosophila septate junctions. A paranodal junction flanks the node of Ranvier in myelinated nerve, electrically isolates the myelinated from unmyelinated nerve segments, and physically separates the voltage-gated sodium channels at the node from the cluster of potassium channels underneath the myelin sheath." [GOC:pr, PMID:24011083]


id: GO:1990228
name: sulfurtransferase complex
namespace: cellular_component
def:
  "A protein complex capable of catalyzing the transfer of sulfur atoms from one compound (donor) to another (acceptor)." [GOC:bhm, PMID:17350958]


id: GO:1990230
name: iron-sulfur cluster transfer complex
namespace: cellular_component
def:
  "A protein complex capable of catalyzing the transfer of an iron-sulfur (Fe-S) cluster from one compound (donor) to another (acceptor)." [GOC:bhm, PMID:19810706]


id: GO:1990231
name: STING complex
namespace: cellular_component
def:
  "A protein dimer containing two STING monomers. It binds cyclic purine di-nucleotides.  Activation of the sting complex by 2',5'-3'-5'-cyclic GMP-AMP activates nuclear transcription factor kB (NF-kB) and interferon regulatory factor 3 (IRF3) which then induce transcription of the genes encoding type I IFN and cytokines active in the  innate immune response." [GOC:bhm, PMID:22705373, PMID:23706668, PMID:23910378]


id: GO:1990233
name: intramolecular phosphotransferase complex
namespace: cellular_component
def:
  "A protein complex capable of catalyzing the transfer of a phosphate group from one position to another within a single molecule." [GOC:bhm, PMID:16540464]


id: GO:1990234
name: transferase complex
namespace: cellular_component
def:
  "A protein complex capable of catalyzing the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor)." [GOC:bhm, PMID:16540464]


id: GO:1990235
name: diamine N-acetyltransferase complex
namespace: cellular_component
def:
  "A protein complex which is capable of diamine N-acetyltransferase activity." [GOC:bhm, PMID:8077207]


id: GO:1990236
name: proteasome core complex import into nucleus
namespace: biological_process
def:
  "The directed movement of the proteasome core complex (AKA core particle (CP)) from the cytoplasm into the nucleus." [GOC:dos, GOC:rb, PMID:23982732]


id: GO:1990237
name: sequestration of proteasome core complex in proteasome storage granule
namespace: biological_process
def:
  "Any process where the proteasome core particle (CP) is sequestered in the protein storage granule in the cytoplasm." [GOC:rb, PMID:23982732]


id: GO:1990238
name: double-stranded DNA endodeoxyribonuclease activity
namespace: molecular_function
def:
  "Catalysis of the hydrolysis of ester linkages within a double-stranded deoxyribonucleic acid molecule by creating internal breaks." [GOC:PG, PMID:22885404]


id: GO:1990241
name: obsolete nucleotide binding complex
namespace: cellular_component
def:
  "OBSOLETE. A protein complex that interacts selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose. An example of this is STING in E. coli (Q86WV6)." [GOC:bhm, PMID:23910378]


id: GO:1990243
name: atf1-pcr1 complex
namespace: cellular_component
def:
  "A heterodimeric transcription factor complex composed of the bZIP proteins atf1 and pcr1. The heterodimer binds m26 sites (homologous to CRE)." [PMID:24224056]


id: GO:1990244
name: histone kinase activity (H2A-T120 specific)
namespace: molecular_function
def:
  "Catalysis of the transfer of a phosphate group to the threonine-120 residue of histone H2A." [PMID:24140421]


id: GO:1990245
name: histone H2A-T120 phosphorylation
namespace: biological_process
def:
  "The modification of histone H2A by the addition of a phosphate group to a threonine residue at position 120 of the histone." [PMID:24140421]


id: GO:1990246
name: uniplex complex
namespace: cellular_component
def:
  "A calcium channel complex in the mitochondrial inner membrane capable of highly-selective calcium channel activity. Its components include the EF-hand-containing proteins mitochondrial calcium uptake 1 (MICU1) and MICU2, the pore-forming subunit mitochondrial calcium uniporter (MCU) and its paralog MCUb, and the MCU regulator EMRE." [PMID:24231807]


id: GO:1990247
name: N6-methyladenosine-containing RNA binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with an RNA molecule modified by N6-methyladenosine (m6A), a modification present at internal sites of mRNAs and some non-coding RNAs." [PMID:22575960, PMID:24284625]


id: GO:1990248
name: regulation of transcription from RNA polymerase II promoter in response to DNA damage
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of DNA damage." [PMID:15660129]


id: GO:1990249
name: nucleotide-excision repair, DNA damage recognition complex
namespace: cellular_component
def:
  "A protein complex that is capable of identifying lesions in DNA, such as pyrimidine-dimers, intrastrand cross-links, and bulky adducts. The wide range of substrate specificity suggests that the repair complex recognizes distortions in the DNA helix. It subsequently recruits a nucleotide-excision repair, preincision complex." [GOC:bhm, PMID:22331906]


id: GO:1990250
name: transcription-coupled nucleotide-excision repair, DNA damage recognition complex
namespace: cellular_component
def:
  "A protein complex that is capable of identifying lesions in DNA on the actively transcribed strand of the DNA duplex as well as a small subset of lesions not recognized by the general nucleotide-excision repair pathway. The wide range of substrate specificity suggests that the repair complex recognizes distortions in the DNA helix. It subsequently recruits a nucleotide-excision repair, preincision complex." [GOC:bhm, PMID:22331906]


id: GO:1990251
name: Mmi1 nuclear focus complex
namespace: cellular_component
def:
  "A protein complex that forms during vegetative growth and is involved in the selective degradation of meiosis-specific transcripts. Contains at least Mmi1, or an ortholog of it." [GOC:al, GOC:vw, PMID:16823445, PMID:23980030]


id: GO:1990252
name: Syp1 complex
namespace: cellular_component
def:
  "A protein complex that contributes to the endocytic process and bud growth in yeast. It is involved in the precise timing of actin assembly during endocytosis." [GOC:bhm, PMID:19713939]


id: GO:1990253
name: cellular response to leucine starvation
namespace: biological_process
def:
  "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of leucine." [PMID:19033384]


id: GO:1990254
name: keratin filament binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with a keratin filament, an intermediate filament composed of acidic and basic keratins (types I and II), typically expressed in epithelial cells." [GOC:krc, PMID:6170061]


id: GO:1990255
name: subsynaptic reticulum organization
namespace: biological_process
def:
  "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a subsynaptic reticulum. A subsynaptic reticulum is an elaborate tubulolamellar membrane system that underlies the postsynaptic cell membrane." [PMID:21041451]


id: GO:1990256
name: signal clustering
namespace: biological_process
def:
  "Grouping of multiple copies of a signal at a cellular location. May promote receptor clustering and alter the signal transduction response." [GOC:als, PMID:12011072, PMID:15603739]


id: GO:1990257
name: piccolo-bassoon transport vesicle
namespace: cellular_component
def:
  "A cytoplasmic dense-core vesicle that transports a range of proteins including piccolo, bassoon, N-cadherin and syntaxin. The transported proteins may be associated with the external side of the vesicle, rather than being contained within the vesicle, therefore forming an aggregate of vesicle and proteins. Piccolo-bassoon transport vesicles (or PTVs) range in size from approximately 80 nm in diameter for dense core vesicles to 130 nm by 220 nm in area for aggregates. They are packaged via the trans-Golgi network before being transported through the axon." [GOC:dr, PMID:21569270]


id: GO:1990258
name: histone glutamine methylation
namespace: biological_process
def:
  "The modification of a histone by addition of a methyl group to an glutamine residue." [PMID:24352239]


id: GO:1990259
name: histone-glutamine methyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: S-adenosyl-L-methionine + (histone)-glutamine = S-adenosyl-L-homocysteine + (histone)-N5-methyl-glutamine." [PMID:24352239]


id: GO:1990260
namespace: biological_process
name:
  negative regulation of transcription from RNA polymerase II promoter by transcription factor localization involved in response to DNA damage checkpoint signaling

def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter using a mechanism that involves the localization of a transcription factor and initiated in response to the DNA damage checkpoint signaling." [PMID:24006488]


id: GO:1990261
name: pre-mRNA catabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the breakdown of the unspliced pre-mRNA (pre-messenger RNA)." [GOC:rb, PMID:22844259]


id: GO:1990262
name: anti-Mullerian hormone signaling pathway
namespace: biological_process
def:
  "A series of molecular signals initiated by the binding of anti-Mullerian hormone to its receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:hjd, PMID:23624077]


id: GO:1990264
name: peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity
namespace: biological_process
def:
  "Any peptidyl-tyrosine dephosphorylation that is involved in inactivation of protein kinase activity." [PMID:7501024]


id: GO:1990265
name: platelet-derived growth factor complex
namespace: cellular_component
def:
  "A protein complex consisting of two chains of platelet-derived growth factor (PDGF) subunits. PDGF dimers bind to PDGF receptors in the plasma membrane and induce receptor dimerisation and activation. PDGFs are involved in a wide variety of signalling processes. PDGFs are found in all vertebrates where at least 2 different chains (A and B) exist. In human (and other mammals), four types of PDGF chains (A, B, C, and D) are known which form five different dimers (AA, AB, BB, CC and DD)." [GOC:bhm, IntAct:EBI-2881436, IntAct:EBI-2881443, IntAct:EBI-2881451, PMID:11331882]


id: GO:1990266
name: neutrophil migration
namespace: biological_process
def:
  "The movement of an neutrophil within or between different tissues and organs of the body." [PMID:1826836]


id: GO:1990267
name: response to transition metal nanoparticle
namespace: biological_process
def:
  "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a transition metal nanoparticle." [PMID:23150627]


id: GO:1990268
name: response to gold nanoparticle
namespace: biological_process
def:
  "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gold nanoparticle stimulus." [PMID:23150627]


id: GO:1990269
name: RNA polymerase II C-terminal domain phosphoserine binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with phosphorylated serine residues in the C-terminal domain of RNA polymerase II." [GOC:di, PMID:22796944]


id: GO:1990270
name: platelet-derived growth factor receptor-ligand complex
namespace: cellular_component
def:
  "A tetrameric protein complex consisting of two platelet-derived growth factor (PDGF) receptor subunits and two PDGF ligand subunits. Binding of the PDGF ligand dimer to the PDGF receptor in the plasma membrane induces receptor dimerisation and activation. PDGFs are involved in a wide variety of signalling processes and are found in all vertebrates. At least two different receptor chains (A and B) and four types of ligand chains (A, B, C, and D) are known forming a wide variety of combinations of receptor-ligand complexes." [GOC:bhm, IntACT:EBI-9080360, PMID:11331882]


id: GO:1990271
name: obsolete anti-Mullerian hormone
namespace: molecular_function
def:
  "OBSOLETE. Combining with anti-Mullerian hormone to initiate a change in cell activity." [GOC:hjd, PMID:23624077]


id: GO:1990272
name: anti-Mullerian hormone receptor activity
namespace: molecular_function
def:
  "Combining with anti-Mullerian hormone to initiate a change in cell activity." [GOC:hjd, PMID:23624077]


id: GO:1990274
name: mitotic actomyosin contractile ring disassembly
namespace: biological_process
def:
  "Any disaggregation of an actomyosin contractile ring into its constituent components that is involved in a mitotic cell cycle." [PMID:14602073, PMID:22891673]


id: GO:1990275
name: preribosome binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with any part of a preribosome." [GOC:di, PMID:22735702]


id: GO:1990276
name: RNA 5'-methyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to the 5'-gamma-phosphate in an RNA molecule." [GOC:al, GOC:vw, PMID:22740346]


id: GO:1990277
name: parasexual conjugation with cellular fusion
namespace: biological_process
def:
  "A conjugation process that results in the union of cellular and genetic information from compatible mating types, without the formation of zygotes. An example of this process is found in Candida albicans." [GOC:di]


id: GO:1990278
name: obsolete positive regulation of MBF transcription factor activity
namespace: biological_process
def:
  "OBSOLETE. Any process that activates or increases the frequency, rate or extent of activity of the transcription factor MBF." [PMID:11795845]


id: GO:1990279
name: obsolete negative regulation of MBF transcription factor activity
namespace: biological_process
def:
  "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of the transcription factor MBF." [PMID:24006488]


id: GO:1990280
name: RNA localization to chromatin
namespace: biological_process
def:
  "A process in which RNA is transported to and maintained in a part of a chromosome that is organized into chromatin." [GOC:dos, GOC:mah, PMID:22582262]


id: GO:1990281
name: efflux pump complex
namespace: cellular_component
def:
  "A protein complex that is capable of efflux transmembrane transporter activity." [GOC:dos, PMID:21556065, PMID:9417051]


id: GO:1990294
name: peptidyl-threonine trans-autophosphorylation
namespace: biological_process
def:
  "The phosphorylation of a peptidyl-threonine to form peptidyl-O-phospho-L-threonine on an identical protein. For example, phosphorylation by the other kinase within a homodimer." [PMID:19357077]


id: GO:1990295
name: post-anaphase microtubule array
namespace: cellular_component
def:
  "A cytoskeletal part that consists of an array of microtubules and associated molecules that forms at the end of anaphase, and in which microtubules are nucleated from an equatorial microtubule organizing center." [PMID:11792817, PMID:17072892, PMID:9601091]


id: GO:1990296
name: scaffoldin complex
namespace: cellular_component
def:
  "A protein complex that contains one or more scaffoldin proteins and several cellulosomal enzymes." [PMID:15197390, PMID:20373916]


id: GO:1990297
name: renal amino acid absorption
namespace: biological_process
def:
  "A renal system process in which amino acids are taken up from the collecting ducts, glomerulus and proximal and distal loops of the nephron. In non-mammalian species, absorption may occur in related structures." [GOC:hjd, PMID:1526373]


id: GO:1990299
name: Bub1-Bub3 complex localization to kinetochore
namespace: biological_process
def:
  "A cellular protein complex localization that acts on a Bub1-Bub3 complex; as a result, the complex is transported to, or maintained in, a specific location at the kinetochore." [PMID:22521786]


id: GO:1990300
name: cellulosome binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with the cellulosome, an extracellular multi-enzyme complex containing several enzymes aligned on a non-catalytic scaffolding that functions to hydrolyze plant cell wall polysaccharides." [PMID:11893054, PMID:15197390]


id: GO:1990301
name: scaffoldin complex binding
namespace: molecular_function
def:
  "A protein complex that contains one or more scaffoldin proteins and several cellulosomal enzymes ant that interacts selectively and non-covalently with the scaffoldin complex." [PMID:11893054, PMID:15197390]


id: GO:1990302
name: Bre1-Rad6 ubiquitin ligase complex
namespace: cellular_component
def:
  "A ubiquitin ligase complex consisting of Bre1 and Rad6 that mediates monoubiquitination of histone H2B to form H2BK123ub1. H2BK123ub1 gives a specific tag for epigenetic transcriptional activation, elongation by RNA polymerase II, telomeric silencing, and is also a prerequisite for H3K4me and H3K79me formation. It thereby plays a central role in histone code and gene regulation. It also modulates the formation of double-strand breaks during meiosis." [GOC:bhm, IntAct:EBI-9102228, PMID:19531475]


id: GO:1990303
name: UBR1-RAD6 ubiquitin ligase complex
namespace: cellular_component
def:
  "A ubiquitin ligase complex consisting of UBR1 and RAD6 components. It polyubiquitinates proteins containing non-acetylated N-terminal residues causing their subsequent degradation by the proteasome as part of the Ac/N-End Rule pathway. It recognizes non-acetylated N-terminal methionine if it is followed by a hydrophobic residue. Additionally, it acts in an N-end rule independent manner as a component of a novel quality control pathway for proteins synthesized on cytosolic ribosomes." [GOC:bhm, IntAct:EBI-9103673, PMID:19531475]


id: GO:1990304
name: MUB1-RAD6-UBR2 ubiquitin ligase complex
namespace: cellular_component
def:
  "A ubiquitin ligase complex consisting of MUB1, RAD6 and UBR2 components. It ubiquitinates, and targets for destruction, the RPN4 transcription factor, which upregulates the proteasome genes. The binding of MUB1 may position the RPN4 ubiquitylation site proximal to the Ubiquitin-RAD6 thioester and allow the transfer of Ubiquitin from RAD6 to RPN4. One of its components, MUB1, is a short-lived protein ubiquitinated by the UBR2-RAD6 ubiquitin conjugating enzyme." [GOC:bhm, IntAct:EBI-9117531, PMID:18070918]


id: GO:1990305
name: RAD6-UBR2 ubiquitin ligase complex
namespace: cellular_component
def:
  "A ubiquitin ligase complex consisting of RAD6 and UBR2 components. It may act in a quality control pathway for proteins synthesized on cytosolic ribosomes. The UBR2 component lacks sequence motifs required for N-end rule degradation." [GOC:bhm, IntAct:EBI-9116509, PMID:15504724]


id: GO:1990306
name: RSP5-BUL ubiquitin ligase complex
namespace: cellular_component
def:
  "A ubiquitin ligase complex consisting of RSP5 and BUL components. It polyubiquinates plasma membrane transporters and permeases, required for their endocytosis and subsequent degradation in the vacuole. BUL1 or BUL2, respectively, bind to the target protein, enabling ubiquitylation by Rsp5. Phosphorylation of BUL proteins results in binding to 14-3-3 proteins, protecting the permeases from down-regulation." [GOC:bhm, IntAct:EBI-9105217, IntAct:EBI-9105295, PMID:9931424]


id: GO:1990308
name: Type-I dockerin domain binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with a type-I dockerin domain of a protein. Type-I dockerin domain is the binding partner of type-1 cohesin domain." [PMID:23195689, PMID:24080387]


id: GO:1990309
name: Type-II dockerin domain binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with a type-II dockerin domain of a protein. Type-II dockerin domain is the binding partner of type-II cohesin domain." [PMID:23195689, PMID:24080387]


id: GO:1990310
name: Type-III dockerin domain binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with a type-III dockerin domain of a protein. Type-III dockerin domain is the binding partner of type-III cohesin domain." [PMID:23195689, PMID:24080387]


id: GO:1990311
name: Type-I cohesin domain binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with a type-I cohesin domain of a protein. Type-I cohesin domain is the binding partner of type-I dockerin domain." [PMID:23195689, PMID:24080387]


id: GO:1990312
name: Type-II cohesin domain binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with a type-II cohesin domain of a protein. Type-II cohesin domain is the binding partner of type-II dockerin domain." [PMID:23195689, PMID:24080387]


id: GO:1990313
name: Type-III cohesin domain binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with a type-III cohesin domain of a protein. Type-III cohesin domain is the binding partner of type-III dockerin domain." [PMID:23195689, PMID:24080387]


id: GO:1990314
name: cellular response to insulin-like growth factor stimulus
namespace: biological_process
def:
  "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin-like growth factor stimulus." [PMID:20042609]


id: GO:1990315
name: Mcs4 RR-MAPKKK complex
namespace: cellular_component
def:
  "A protein complex that consists of a phospho relay component and a MAPK cascade component.  The complex is involved in signaling oxidative stress and osmostress." [PMID:24255738]


id: GO:1990316
name: ATG1/ULK1 kinase complex
namespace: cellular_component
def:
  "A protein complex consisting of ATG1/ULK1 and ATG13 along with other proteins that regulate its function (e.g. ATG17 in yeast or RB1CC1(FIP200) in mammals). This complex has serine/threonine protein kinase activity and is involved in autophagosome formation." [GOC:bhm, GOC:DOS, GOC:rb, IntAct:EBI-2352849, PMID:15743910, PMID:19211835, PMID:19258318, PMID:19597335, PMID:22885598]


id: GO:1990317
name: Gin4 complex
namespace: cellular_component
def:
  "A protein complex involved in septin ring formation during mitosis. In Saccharomyces cerevisiae it consists of BNI5, CDC3, CDC10, CDC11, CDC12, GIN4, NAP1 and SHS1. At least 2 GIN4 molecules are involved." [GOC:bhm, IntAct:EBI-2431392, PMID:12058072]


id: GO:1990318
name: collagen type XIX trimer
namespace: cellular_component
def:
  "A collagen homotrimer of alpha1(XIX) chains; type XIX collagen triple helices localize to basement membrane zones in differentiating muscle cells." [GOC:bhm, IntAct:EBI-2529092, PMID:17876790]


id: GO:1990320
name: collagen type XXI trimer
namespace: cellular_component
def:
  "A collagen homotrimer of alpha1(XXI) chains; type XXI collagen triple helices found in the extracellular matrix component of blood vessel walls and in the cytoplasm of cultured human aortic smooth muscle." [GOC:bhm, IntAct:EBI-2529143, PMID:17876790]


id: GO:1990321
name: collagen type XXII trimer
namespace: cellular_component
def:
  "A collagen homotrimer of alpha1(XXII) chains; type XXII collagen triple helices acts as a cell adhesion ligand for skin epithelial cells and fibroblasts." [GOC:bhm, IntAct:EBI-2529189, PMID:17876790]


id: GO:1990322
name: collagen type XXIII trimer
namespace: cellular_component
def:
  "A collagen homotrimer of alpha1(XXIII) chains; type XXIII collagen triple helices span the plasma membrane." [GOC:bhm, IntAct:EBI-2529234, PMID:17876790]


id: GO:1990323
name: collagen type XXIV trimer
namespace: cellular_component
def:
  "A collagen homotrimer of alpha1(XXIV) chains; type XXIV collagen triple helices may participate in regulating type I collagen fibrillogenesis at specific anatomical locations during fetal development." [GOC:bhm, IntAct:EBI-2529258, PMID:17876790]


id: GO:1990325
name: collagen type XXVII trimer
namespace: cellular_component
def:
  "A collagen homotrimer of alpha1(XXVII) chains. These trimers form thin, non-striated fibrils. Type XXVII collagen triple helices play a role during the calcification of cartilage and the transition of cartilage to bone." [GOC:bhm, IntAct:EBI-2529377, PMID:17876790, PMID:21421911]


id: GO:1990327
name: collagen type XXV trimer
namespace: cellular_component
def:
  "A collagen homotrimer of alpha1(XXV) chains; type XXV collagen triple helices span the plasma membrane." [GOC:bhm, IntAct:EBI-2529312, PMID:17876790]


id: GO:1990328
name: RNA polymerase II, RPB4-RPB7 subcomplex
namespace: cellular_component
def:
  "A protein complexes that mediates transcription and the two major cytoplasmic mRNA decay pathways and is required for efficient translation initiation in association with RNA polymerase II (Pol II)." [GOC:bhm, IntAct:EBI-2945755, PMID:15591044]


id: GO:1990329
name: IscS-TusA complex
namespace: cellular_component
def:
  "A heterotetrameric protein complex involved in the sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm5s2U) at tRNA wobble positions. In E. coli it consists of a central IscS dimer with the two TusA protomers bound to one of the IscS units each via persulfide (-SSH) groups." [GOC:bhm, IntAct:EBI-8869931, PMID:20404999]


id: GO:1990330
name: IscS-IscU complex
namespace: cellular_component
def:
  "A heterotetrameric protein complex involved in the sulfur transfer during iron-sulfur cluster assembly and in the modification of tRNA wobble positions. In E. coli it consisting of a central IscS dimer with the IscU protomers attached to one of the IscS units each via a disulfide (-SSH) group." [GOC:bhm, IntAct:EBI-8870238, PMID:20404999]


id: GO:1990331
name: Hpa2 acetyltransferase complex
namespace: cellular_component
def:
  "A tetrameric protein complex capable of acetyltransferase activity. It can catalyze the transfer of an acetyl group from acetyl-CoA to an acceptor residue on histone H-3, histone H-4, or on polyamines. The complex is also capable of acetylating certain small basic proteins. The two Hpa2 dimers that make up the tetramer are held together by interactions between the bound acetyl-CoA molecules." [GOC:bhm, IntAct:EBI-8871758, PMID:10600387]


id: GO:1990332
name: Ire1 complex
namespace: cellular_component
def:
  "A type-I transmembrane protein complex located in the endoplasmic reticulum (ER) consisting of an IRE1-IRE1 dimer, which forms in response to the accumulation of unfolded protein in the ER. The dimeric complex has endoribonuclease (RNase) activity and evokes the unfolded protein response (UPR) by cleaving an intron of a mRNA coding for the transcription factor HAC1 in yeast or XBP1 in mammals; the complex cleaves a single phosphodiester bond in each of two RNA hairpins (with non-specific base paired stems and loops of consensus sequence CNCNNGN, where N is any base) to remove an intervening intron from the target transcript." [GOC:bf, GOC:bhm, IntAct:EBI-8872439, PMID:18191223, PMID:25437541]


id: GO:1990333
name: mitotic checkpoint complex, CDC20-MAD2 subcomplex
namespace: cellular_component
def:
  "A protein complex involved in the spindle checkpoint, preventing the activation of the anaphase-promoting complex until all chromosomes are correctly attached in a bipolar fashion to the mitotic spindle. In budding yeast this complex consists of Mad2p and Cdc20p, and in mammalian cells it consists of MAD2 and CDC20." [GOC:bhm, IntAct:EBI-1270646, PMID:15879521]


id: GO:1990334
name: Bfa1-Bub2 complex
namespace: cellular_component
def:
  "A protein complex that acts as a two-component GTPase-activating protein for Tem1 GTPase, thus regulating a signal transduction cascade, called the mitotic exit network (MEN), which is required for mitotic exit and cytokinesis. Bub2/Bfa1 keeps Tem1 inactive until the spindle is properly oriented, thus inhibiting MEN activation." [GOC:bhm, IntAct:EBI-1271344, PMID:16449187]


id: GO:1990338
name: laminin-13 complex
namespace: cellular_component
def:
  "A laminin complex composed of alpha4, beta2 and gamma3 polypeptide chains." [GOC:bhm, IntAct:EBI-2530020, PMID:17453709]


id: GO:1990339
name: laminin-14 complex
namespace: cellular_component
def:
  "A laminin complex composed of alpha5, beta2 and gamma2 polypeptide chains." [GOC:bhm, IntAct:EBI-2530034, PMID:17453709]


id: GO:1990340
name: laminin-15 complex
namespace: cellular_component
def:
  "A laminin complex composed of alpha5, beta2 and gamma3 polypeptide chains." [GOC:bhm, IntAct:EBI-2530049, PMID:17453709]


id: GO:1990341
name: thrombospondin complex
namespace: cellular_component
def:
  "A homotrimeric or homopentameric glycoprotein that functions at the interface of the cell membrane and the extracellular matrix through its interactions with proteins and proteoglycans, such as collagens, integrins and fibronectin, to regulate matrix structure and cellular behaviour." [GOC:bhm, IntAct:EBI-2530370, IntAct:EBI-2530917, IntAct:EBI-2530961, IntAct:EBI-2530975, IntAct:EBI-2531058, IntAct:EBI-9251379, IntAct:EBI-9251408, IntAct:EBI-9251455, IntAct:EBI-9251502, IntAct:EBI-9251524, PMID:18193164]


id: GO:1990342
name: heterochromatin island
namespace: cellular_component
def:
  "A region of heterochromatin that is formed dynamically in response to environmental signals by a process that does not require RNAi, and is enriched in histone H3 methylated on lysine 9 (H3K9me)." [PMID:22144463, PMID:24210919]


id: GO:1990343
name: heterochromatin domain
namespace: cellular_component
def:
  "A region of heterochromatin that is formed dynamically under specific growth conditions by a process that requires RNAi, and is enriched in histone H3 methylated on lysine 9 (H3K9me)." [PMID:23151475, PMID:24210919]


id: GO:1990344
name: secondary cell septum biogenesis
namespace: biological_process
def:
  "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a secondary cell septum following nuclear division." [PMID:22891259]


id: GO:1990345
name: MTREC complex
namespace: cellular_component
def:
  "A protein complex that consists of a heterodimer formed by Red1 and Mtl1 or homologs thereof, and that promotes degradation of mRNAs and noncoding RNAs and associates with different proteins to assemble heterochromatin via distinct mechanisms." [PMID:24210919]


id: GO:1990346
name: BID-BCL-xl complex
namespace: cellular_component
def:
  "A heterodimeric protein complex consisting of BID and BCL-xl, members of the Bcl-2 family of anti- and proapoptotic regulators." [GOC:bhm, IntAct:EBI-709568, IntAct:EBI-822507, IntAct:EBI-822526, PMID:14634621]


id: GO:1990347
name: obsolete G*/A mismatch-specific adenine-DNA glycosylase activity
namespace: molecular_function
def:
  "OBSOLETE. Catalysis of the removal of adenine misinserted into nascent strand opposite 8-oxoG in the template by adenine DNA glycosylase activity. The reaction leaves an apyrimidinic (AP) site." [PMID:24559510]


id: GO:1990348
name: obsolete G/A mismatch specific adenine DNA glycosylase activity
namespace: molecular_function
def:
  "OBSOLETE. Catalysis of the removal of adenine misinserted into nascent strand opposite guanine in the template by adenine DNA glycosylase activity. The reaction leaves an apurinic AP site. I also requested same term but for Go/A mismatch. If you think it is better to make one term for mismatched adenine that is fine by me." [PMID:9737967]


id: GO:1990349
name: gap junction-mediated intercellular transport
namespace: biological_process
def:
  "The movement of substances between cells via gap junctions. A gap junction is a fine cytoplasmic channel, found in animal cells, that connects the cytoplasm of one cell to that of an adjacent cell, allowing ions and other molecules to pass freely between the two cells." [GOC:hjd, PMID:14506308, PMID:23261543, Wikipedia:Gap_junction]


id: GO:1990350
name: glucose transporter complex
namespace: cellular_component
def:
  "A protein complex facilitating glucose transport into, out of or within a cell, or between cells." [GOC:bhm, IntAct:EBI-959455, IntAct:EBI-960644, IntAct:EBI-960674, PMID:15449578]


id: GO:1990351
name: transporter complex
namespace: cellular_component
def:
  "A protein complex facilitating transport of molecules (proteins, small molecules, nucleic acids) into, out of or within a cell, or between cells." [GOC:bhm, IntAct:EBI-959455, PMID:15449578]


id: GO:1990352
name: BRE1 E3 ubiquitin ligase complex
namespace: cellular_component
def:
  "A homodimeric protein complex composed of the E3 ubiquitin-protein ligase BRE1. Plays a role in regulating association of RNA polymerase II with active genes." [GOC:bhm, IntAct:EBI-9102292, PMID:19531475]


id: GO:1990353
name: Fused-Smurf ubiquitin ligase complex
namespace: cellular_component
def:
  "A ubiquitin ligase complex. In D. melanogaster, it regulates ubiquitination and proteolysis of the BMP receptor Thickveins in cystoblasts, potentially by controlling Tkv ubiquitination and degradation." [GOC:bhm, IntAct:EBI-3405462, PMID:21145463]


id: GO:1990354
name: activated SUMO-E1 ligase complex
namespace: cellular_component
def:
  "A protein complex consisting of a SUMO protein bound to a SUMO activating enzyme complex. Activation by the E1 complex and linkage to the E2 enzyme UBE2I is required for the formation of covalent bonds between SUMO and its ultimate target proteins." [GOC:bhm, Intact:EBI-9345927, PMID:15660128]


id: GO:1990356
name: sumoylated E2 ligase complex
namespace: cellular_component
def:
  "A protein complex consisting of a SUMO (small ubiquitin-related modifier) protein bound to a SUMO-conjugating E2 ligase. Sumoylation of the E2 ligase is an intermediate step required for the formation of covalent bonds between a SUMO protein and its ultimate protein target. SUMO is transferred to the E2 ligase by a SUMO-activating E1 enzyme. Sumoylation of the target protein is either facilitated directly by the sumoylated E2 ligase or aided by an optional E3 ligase." [GOC:bhm, IntAct:EBI-9347978, PMID:18691969]


id: GO:1990357
name: terminal web
namespace: cellular_component
def:
  "An actin-rich cytoskeletal network located beneath the microvilli of the apical plasma membrane of polarized epithelial cells. In addition to actin filaments, the terminal web may contain actin-binding proteins, myosin motor proteins, and intermediate filaments. The terminal web can function as a contractile structure that influences the spatial distribution of microvilli as well as the development and morphogenesis of tissues containing polarized epithelial cells." [GOC:kmv, http://en.wikipedia.org/wiki/Terminal_web, PMID:19437512, PMID:24677443, PMID:7511618]


id: GO:1990358
name: xylanosome
namespace: cellular_component
def:
  "A multifunctional supermolecular complex, containing several proteins with hemicellulase activity. Functions to hydrolyze hemicellulose." [PMID:16769147]


id: GO:1990359
name: stress response to zinc ion
namespace: biological_process
def:
  "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis caused by a zinc ion stimulus." [GOC:kmv, pmid:17888400]


id: GO:1990360
name: PKM2 protein kinase complex
namespace: cellular_component
def:
  "A protein complex capable of phosphorylating a large number of protein targets. Contributes to cell proliferation under glycose starvation conditions. In human, the complex is present as a dimer." [GOC:bhm, PMID:24606918]


id: GO:1990361
name: PKM2 pyruvate kinase complex
namespace: cellular_component
def:
  "A protein complex capable of pyruvate kinase activity. PKM2 only exists as homotetramer when bound to beta-d-fructofuranose 1,6-bisphosphate (CHEBI:28013)." [GOC:bhm, PMID:24606918]


id: GO:1990362
name: butanol dehydrogenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: butanal + NADH + H+ => n-butanol + NAD+." [GOC:mengo_curators, PMID:1999395]


id: GO:1990363
name: obsolete response to hydrolysate
namespace: biological_process
def:
  "OBSOLETE. Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of hydrolysate (any product of hydrolysis)." [GOC:mengo_curators, PMID:23356676]


id: GO:1990364
name: obsolete response to aldehyde
namespace: biological_process
def:
  "OBSOLETE. Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an aldehyde." [GOC:mengo_curators, PMID:23356676]


id: GO:1990365
name: obsolete response to phenol
namespace: biological_process
def:
  "OBSOLETE. Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of phenols." [GOC:mengo_curators, PMID:23356676]


id: GO:1990366
name: obsolete response to organic acid
namespace: biological_process
def:
  "OBSOLETE. Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic acid." [GOC:mengo_curators, PMID:23356676]


id: GO:1990367
name: process resulting in tolerance to organic substance
namespace: biological_process
def:
  "A response that results in a state of tolerance to an organic substance." [GOC:mengo_curators, PMID:23356676]


id: GO:1990368
name: obsolete process resulting in tolerance to hydrolysate
namespace: biological_process
def:
  "OBSOLETE. A response that results in a state of tolerance to hydrolysate (product of hydrolysis)." [GOC:mengo_curators, PMID:23356676]


id: GO:1990372
name: process resulting in tolerance to organic acid
namespace: biological_process
def:
  "A response that results in a state of tolerance to organic acid." [GOC:mengo_curators, PMID:23356676]


id: GO:1990374
name: Kir2 inward rectifier potassium channel complex
namespace: cellular_component
def:
  "A inward rectifier potassium channel complex. Homo- or heterotetramer composed of subunits of the eukaryotic Kir2 protein family. Plays a key role in maintaining the correct resting potential in eukaryotic cells." [GOC:bhm, IntAct:EBI-9510554, IntAct:EBI-9511072, PMID:16834334]


id: GO:1990375
name: baculum development
namespace: biological_process
def:
  "The reproductive developmental process whose specific outcome is the progression of the baculum over time, from its formation to the mature structure." [GOC:sl, PMID:21471296]


id: GO:1990376
namespace: biological_process
name:
  negative regulation of G1/S transition of mitotic cell cycle by positive regulation of transcription from RNA polymerase II promoter in response to nitrogen starvation

def:
  "A positive regulation of transcription from RNA polymerase II promoter in response to nitrogen starvation that results in negative regulation of mitotic G1/S transition." [PMID:9135083]


id: GO:1990377
name: organomineral extracellular matrix
namespace: cellular_component
def:
  "An extracellular matrix consisting of a densely packed organomineral assembly in which the mineral phase represents the majority of the material by weight." [GOC:jh2, PMID:15994301]


id: GO:1990378
name: upstream stimulatory factor complex
namespace: cellular_component
def:
  "A protein complex capable of sequence-specific DNA binding RNA polymerase II transcription factor activity through binding to a symmetrical DNA sequence (E-boxes) (5'-CACGTG-3'). Found in a variety of viral and cellular promoters." [GOC:bhm, IntAct:EBI-9518693, PMID:8576131]


id: GO:1990379
name: lipid transport across blood brain barrier
namespace: biological_process
def:
  "The directed movement of lipid molecules passing through the blood-brain barrier." [GOC:sjp, PMID:24345162]


id: GO:1990380
name: Lys48-specific deubiquitinase activity
namespace: molecular_function
def:
  "Hydrolysis of Lys48-linked ubiquitin unit(s) from a ubiquitinated protein." [GOC:bf, GOC:PARL, PMID:22970133]


id: GO:1990381
name: ubiquitin-specific protease binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with a ubiquitin-specific protease." [GOC:bf, GOC:PARL, PMID:24063750]


id: GO:1990382
name: obsolete melanosome assembly
namespace: biological_process
def:
  "OBSOLETE. The aggregation, arrangement and bonding together of a set of components to form a melanosome, a tissue-specific, membrane-bounded cytoplasmic organelle within which melanin pigments are synthesized and stored." [GOC:bf, GOC:PARL, PMID:22511774]


id: GO:1990383
name: cellular response to biotin starvation
namespace: biological_process
def:
  "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of biotin." [PMID:12557275]


id: GO:1990384
name: hyaloid vascular plexus regression
namespace: biological_process
def:
  "The developmental process in which the hyaloid vascular plexus is destroyed as a part of its normal progression." [GOC:hjd, PMID:18841878]


id: GO:1990385
name: meiotic spindle midzone
namespace: cellular_component
def:
  "The area in the center of the meiotic spindle where the spindle microtubules from opposite poles overlap." [GOC:kmv\,PMID\:12707312]


id: GO:1990386
name: mitotic cleavage furrow ingression
namespace: biological_process
def:
  "Advancement of the mitotic cleavage furrow from the outside of the cell inward towards the center of the cell. The cleavage furrow acts as a 'purse string' which draws tight to separate daughter cells during mitotic cytokinesis and partition the cytoplasm between the two daughter cells. The furrow ingresses until a cytoplasmic bridge is formed." [GOC:kmv, PMID:12707312]


id: GO:1990387
name: isogloboside biosynthetic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of a lactosyl-ceramide derivative in which a galactose is linked to the galactose via an alpha 1,3 linkage (vs alpha 1,4 for globosides)." [GOC:hjd, PMID:22875802]


id: GO:1990389
name: CUE1-UBC7 ubiquitin-conjugating enzyme complex
namespace: cellular_component
def:
  "A protein complex capable of ubiquitin-conjugating enzyme activity during ER-associated protein degradation (ERAD). In S. cerevisiae, UBC7 is the ubiquitin-conjugating enzyme (E2) and requires binding to the ER surface by CUE1." [GOC:bhm, IntAct:EBI-9207004, PMID:23028185]


id: GO:1990390
name: protein K33-linked ubiquitination
namespace: biological_process
def:
  "A protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 33 of the ubiquitin monomers, is added to a protein." [PMID:24768539]


id: GO:1990391
name: DNA repair complex
namespace: cellular_component
def:
  "A protein complex involved in DNA repair processes including direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [GOC:bhm, PMID:22749910]


id: GO:1990392
name: EFF-1 complex
namespace: cellular_component
def:
  "A trimeric cell-cell fusion complex that serves as a scaffold for zippering up the extracellular domains, bringing the transmembrane segments into close proximity such that they can continue zippering within the two membranes into one. Two prefusion monomers cluster at the surface of adjacent cells. Parallel EFF-1 interactions occur across cells and a third monomer, which can come from either cell, adds on to make an intermediate, extended trimer." [GOC:bhm, IntAct:EBI-9526622, PMID:24725407]


id: GO:1990393
name: 3M complex
namespace: cellular_component
def:
  "A protein complex, at least composed of CUL7, CCDC8 and OBSL1, that is required for maintaining microtubule and genome integrity." [PMID:24793695, PMID:24793696]


id: GO:1990394
name: cellular response to cell wall damage
namespace: biological_process
def:
  "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of cell wall damage. The process begins with detection of the damage and ends with a change in state or activity of the cell." [PMID:17287531]


id: GO:1990395
name: meiotic spindle pole body organization
namespace: biological_process
def:
  "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the meiotic spindle pole body." [GOC:vw]


id: GO:1990396
name: single-strand break repair via homologous recombination
namespace: biological_process
def:
  "The error-free repair of a single-strand break in DNA in which the broken DNA molecule is repaired using homologous sequences. A strand in the broken DNA searches for a homologous region in an intact chromosome to serve as the template for DNA synthesis. The restoration of two intact DNA molecules results in the exchange, reciprocal or nonreciprocal, of genetic material between the intact DNA molecule and the broken DNA molecule." [GOC:bhm, PMID:24339919]


id: GO:1990397
name: queuosine salvage
namespace: biological_process
def:
  "Any process which produces queuosine from derivatives of it, without de novo synthesis." [GOC:vw, PMID:24911101]


id: GO:1990398
name: Cus cation efflux complex
namespace: cellular_component
def:
  "Transmembrane complex that mediates resistance to copper and silver by cation efflux directly from the cell using the proton-motive force. Spans the inner membrane, periplasm, and outer membrane. Primarily activated under anaerobic conditions by CusR and CusS but also expressed under extreme copper stress, in aerobic growth." [GOC:bhm, IntAct:EBI-9010676, PMID:23122209]


id: GO:1990400
name: mitochondrial ribosomal large subunit rRNA binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with the mitochondrial large ribosomal subunit RNA (LSU rRNA), a constituent of the mitochondrial large ribosomal subunit." [PMID:24206665]


id: GO:1990401
name: embryonic lung development
namespace: biological_process
def:
  "The process occurring during the embryonic phase whose specific outcome is the progression of the lung over time, from its formation to the mature structure." [PMID:24785085]


id: GO:1990402
name: embryonic liver development
namespace: biological_process
def:
  "The process occurring during the embryonic phase whose specific outcome is the progression of the liver over time, from its formation to the mature structure." [PMID:15918910]


id: GO:1990403
name: embryonic brain development
namespace: biological_process
def:
  "The process occurring during the embryonic phase whose specific outcome is the progression of the brain over time, from its formation to the mature structure." [PMID:15918910]


id: GO:1990404
name: protein ADP-ribosylase activity
namespace: molecular_function
def:
  "The transfer, from NAD, of ADP-ribose to a protein amino acid residue." [PMID:1899243, RESID:AA0040, RESID:AA0168, RESID:AA0169, RESID:AA0231, RESID:AA0237, RESID:AA0295, wikipedia:ADP-ribosylation]


id: GO:1990406
name: CGRP receptor complex
namespace: cellular_component
def:
  "A transmembrane, G-protein-coupled signalling receptor complex recognized by calcitonin gene-related peptides (CGRP)." [GOC:bhm, IntAct:EBI-9009008, PMID:20826335]


id: GO:1990407
name: calcitonin gene-related peptide binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with calcitonin gene-related peptide (CGRP)." [GOC:bhm, PMID:10882736]


id: GO:1990408
name: calcitonin gene-related peptide receptor signaling pathway
namespace: biological_process
def:
  "A series of molecular signals initiated by an extracellular calcitonin gene-related peptide (CGRP) combining with a calcitonin gene-related peptide receptor on the surface of the target cell. Calcitonin gene-related peptide receptors may form dimers, trimers or tetramers." [GOC:bhm, PMID:10882736]


id: GO:1990410
name: adrenomedullin receptor signaling pathway
namespace: biological_process
def:
  "A series of molecular signals initiated by an extracellular adrenomedullin combining with a dimeric adrenomedullin receptor on the surface of the target cell." [GOC:bhm, PMID:10882736]


id: GO:1990411
name: hercynylcysteine sulfoxide lyase activity (ergothioneine-forming)
namespace: molecular_function
def:
  "Catalysis of the reaction: hercynylcysteine sulfoxide + 2H+ = ergothioneine + pyruvate + ammonium." [PMID:24828577]


id: GO:1990412
name: hercynylselenocysteine lyase activity (selenoneine-forming)
namespace: molecular_function
def:
  "Catalysis of the reaction: hercynylselenocysteine + 2H+ = selenoneine + pyruvate + ammonium." [PMID:24828577]


id: GO:1990413
name: eyespot apparatus
namespace: cellular_component
def:
  "A small pigmented organelle used in single-celled organisms to detect light." [Wikipedia:Eyespot_apparatus]


id: GO:1990414
name: replication-born double-strand break repair via sister chromatid exchange
namespace: biological_process
def:
  "The repair of a replication-born double-strand DNA break in which the DNA molecule is repaired using the homologous sequence of the sister chromatid which serves as a template to repair the breaks." [PMID:12820977, PMID:16888651\,GOC\:rb]


id: GO:1990415
name: Pex17p-Pex14p docking complex
namespace: cellular_component
def:
  "A protein complex involved in the peroxisomal import machinery. In S. cerevisiae, this complex contains the proteins Pex17p, Pex14p, Pex19, and Pex13p." [GOC:rb, PMID:12667447]


id: GO:1990416
name: cellular response to brain-derived neurotrophic factor stimulus
namespace: biological_process
def:
  "A process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a brain-derived neurotrophic factor stimulus." [PMID:21958434]


id: GO:1990418
name: response to insulin-like growth factor stimulus
namespace: biological_process
def:
  "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin-like growth factor stimulus." [PMID:21932665]


id: GO:1990419
name: obsolete response to elemental metal
namespace: biological_process
def:
  "OBSOLETE. Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an elemental metal stimulus." [PMID:22688007]


id: GO:1990420
name: establishment of septation initiation network asymmetry
namespace: biological_process
def:
  "The septation initiation signaling process by which the activity of the septation initiation network (SIN) is activated asymmetrically on the spindle pole bodies." [PMID:22786806]


id: GO:1990421
name: subtelomeric heterochromatin
namespace: cellular_component
def:
  "Heterochromatic regions of the chromosome found at the subtelomeric regions." [PMID:18761674, SO:0001997]


id: GO:1990422
name: glyoxalase (glycolic acid-forming) activity
namespace: molecular_function
def:
  "Catalysis of the reaction: glyoxal + H2O = glycolic acid. Catalysis occurs in the absence of a cofactor." [GOC:bf, GOC:PARL, PMID:22523093]


id: GO:1990423
name: RZZ complex
namespace: cellular_component
def:
  "A kinetochore component required for both meiotic and mitotic spindle assembly checkpoints." [PMID:12686595, PMID:15922598, PMID:20462495]


id: GO:1990424
name: protein arginine kinase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: ATP + a protein arginine = ADP + protein arginine phosphate." [GOC:imk, PMID:22517742]


id: GO:1990425
name: ryanodine receptor complex
namespace: cellular_component
def:
  "A voltage-gated calcium-release channel complex of the sarcoplasmic or endoplasmic reticulum. It plays an important role in the excitation-contraction (E-C) coupling of muscle cells. RyR comprises a family of ryanodine receptors, widely expressed throughout the animal kingdom." [GOC:ame, IntAct:EBI-9632656, PMID:22822064]


id: GO:1990426
name: homologous recombination-dependent replication fork processing
namespace: biological_process
def:
  "Replication fork processing that includes recombination between DNA near the arrested fork and homologous sequences. Proteins involved in homologous recombination are required for replication restart." [GOC:mah, PMID:23093942]


id: GO:1990427
name: stereocilia tip-link density
namespace: cellular_component
def:
  "An electron-dense plaque at either end of a stereocilia tip link that provides the anchor in the stereocilia membrane." [PMID:19447093, PMID:21709241]


id: GO:1990428
name: miRNA transport
namespace: biological_process
def:
  "The directed movement of microRNA (miRNA) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GO:jl, PMID:24356509]


id: GO:1990429
name: peroxisomal importomer complex
namespace: cellular_component
def:
  "A protein complex responsible for transporting proteins into the peroxisomal matrix. An example of this complex is Pex14 found in S. cerevisae which has 9 core components and 12 transient interaction partners." [PMID:20154681, PMID:22375831]


id: GO:1990430
name: extracellular matrix protein binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with a protein that is part of an extracellular matrix." [PMID:22355679]


id: GO:1990433
name: CSL-Notch-Mastermind transcription factor complex
namespace: cellular_component
def:
  "A DNA binding transcription factor complex consisting of CSL and mastermind proteins in complex with the cleaved, intracellular domain of Notch. It is required for both repression and activation of Notch target genes." [GOC:bhm, GOC:dos, intAct:EBI-9636287, PMID:16530045]


id: GO:1990434
name: lower tip-link density
namespace: cellular_component
def:
  "An electron-dense plaque at the lower end of a stereocilia tip link that provides the anchor in the stereocilia membrane at the tip of the stereocilium from which the tip link rises." [PMID:19447093]


id: GO:1990435
name: upper tip-link density
namespace: cellular_component
def:
  "An electron-dense plaque at the upper end of a stereocilia tip link that provides the anchor in the stereocilia membrane on the side of the stereocilium where the tip link ends." [PMID:19447093]


id: GO:1990436
name: obsolete MAPK cascade involved in oxidative stress signaling pathway
namespace: biological_process
def:
  "OBSOLETE. A series of molecular signals in which a MAP kinase cascade activated by oxidative stress relays one or more of the signals, MAP kinase cascades involve at least three protein kinase activities and culminate in the phosphorylation and activation of a MAP kinase. Just FYI in pombe the osmotic stress and oxidative stress MAPK cascade involve many of the same proteins, but the pathways are slightly different, therefore Im req this term." [PMID:10398679]


id: GO:1990437
name: snRNA 2'-O-methylation
namespace: biological_process
def:
  "The posttranscriptional addition of a methyl group to the 2' oxygen atom of a nucleotide residue in an snRNA molecule." [PMID:11842100, PMID:9844635]


id: GO:1990438
name: U6 2'-O-snRNA methylation
namespace: biological_process
def:
  "The posttranscriptional addition a methyl group to the 2'-oxygen atom of a nucleotide residue in an U6 snRNA molecule." [PMID:11842100, PMID:9844635]


id: GO:1990439
name: MAP kinase threonine phosphatase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: MAP kinase threonine phosphate + H2O = MAP kinase tyrosine + phosphate." [PMID:10398679]


id: GO:1990440
namespace: biological_process
name:
  positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress

def:
  "Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of an endoplasmic reticulum stress." [GOC:bf, GOC:PARL, PMID:21113145]


id: GO:1990441
namespace: biological_process
name:
  negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress

def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of an endoplasmic reticulum stress." [GOC:bf, GOC:PARL, PMID:21113145]


id: GO:1990442
name: intrinsic apoptotic signaling pathway in response to nitrosative stress
namespace: biological_process
def:
  "A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced in response to nitrosative stress; a state often resulting from exposure to high levels of nitric oxide (NO) or the highly reactive oxidant peroxynitrite, which is produced following interaction of NO with superoxide anions." [GOC:bf, GOC:PARL, PMID:23985028]


id: GO:1990443
name: peptidyl-threonine autophosphorylation
namespace: biological_process
def:
  "The phosphorylation by a protein of one or more of its own threonine amino acid residues, or a threonine residue on an identical protein." [PMID:7803855]


id: GO:1990444
name: F-box domain binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with an F-box domain of a protein." [GOC:bf, GOC:PARL, InterPro:IPR001810, PMID:12628165]


id: GO:1990445
name: obsolete Multiciliate cell differentiation
namespace: biological_process
def:
  "OBSOLETE. The process in which a relatively unspecialized cell acquires features of a multiciliated cell, a specialized epithelial cell type that extends anywhere from 150 to 200 motile cilia per cell in order to produce a vigorous fluid flow critical to human health in several organ systems." [PMID:22231168, PMID:24934224]


id: GO:1990446
name: U1 snRNP binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with any part of a U1 small nuclear ribonucleoprotein particle." [PMID:14713954]


id: GO:1990447
name: U2 snRNP binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with any part of a U2 small nuclear ribonucleoprotein particle." [PMID:14713954]


id: GO:1990448
name: exon-exon junction complex binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with an exon-exon junction complex, a protein complex deposited by the spliceosome upstream of messenger RNA exon-exon junctions. The exon-exon junction complex provides a binding platform for factors involved in mRNA export and nonsense-mediated mRNA decay." [GOC:sart, PMID:24967911]


id: GO:1990449
name: obsolete amylin receptor
namespace: cellular_component
def:
  "OBSOLETE. A G-protein coupled signalling receptor complex consisting of the calcitonin receptor and a receptor activity-modifying protein (RAMP). Amylin is produced in beta-islet cells of the pancreas. It is implicated in selective inhibition of insulin-stimulated glucose utilization and glycogen deposition in muscle, gastric emptying, gastric acid secretion, postprandial glucagon secretion and food intake and aids weight loss." [GOC:bhm, IntAct:EBI-9008682, IntAct:EBI-9685417, IntAct:EBI-9685439, PMID:10871269]


id: GO:1990450
name: linear polyubiquitin binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with a linear polymer of ubiquitin. Linear ubiquitin polymers are formed by linking the amino-terminal methionine (M1) of one ubiquitin molecule to the carboxy-terminal glycine (G76) of the next." [GOC:bf, GOC:PARL, PMID:23453807]


id: GO:1990451
name: cellular stress response to acidic pH
namespace: biological_process
def:
  "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in the homeostasis of organismal or cellular pH (with pH < 7). pH is a measure of the acidity or basicity of an aqueous solution." [GOC:BHF, GOC:go_curators, GOC:rl, PMID:10615049]


id: GO:1990452
name: Parkin-FBXW7-Cul1 ubiquitin ligase complex
namespace: cellular_component
def:
  "A ubiquitin ligase complex containing Parkin (PARK2), the F-box protein FBXW7 (also called SEL-10) and a cullin from the Cul1 subfamily; substrate specificity is conferred by the F-box protein." [GOC:bf, GOC:PARL, PMID:12628165]


id: GO:1990453
name: nucleosome disassembly/reassembly complex
namespace: cellular_component
def:
  "A protein complex involved in the disassembly and subsequent reassembly of nucleosomes. It associates with the coding region of transcriptionally active genes where it interacts with the RNA polymerase II and affects its processivity during co-transcriptional RNA processing and maturation. It exists as a functionally independent part of the NuA4 complex." [GOC:bhm, IntAct:EBI-9682603, PMID:24843044]


id: GO:1990454
name: L-type voltage-gated calcium channel complex
namespace: cellular_component
def:
  "A type of voltage-dependent calcium channel responsible for excitation-contraction coupling of skeletal, smooth, and cardiac muscle. 'L' stands for 'long-lasting' referring to the length of activation." [GOC:ame, PMID:12946355]


id: GO:1990455
name: PTEN phosphatase complex
namespace: cellular_component
def:
  "A phospholipid phosphatase complex that catalyses the hydrolysis of the second messenger PtdIns (3,4,5)P3. Will also dephosphorylate PtdIns(3,4)P2, PtdIns3P, and Ins(1,3,4,5)P4. Dimerization is critical for its lipid phosphatase function." [GOC:bhm, IntAct:EBI-9637198, IntAct:EBI-9637224, PMID:24766807]


id: GO:1990456
name: mitochondrion-ER tethering
namespace: biological_process
def:
  "The attachment of the mitochondrion to specific sites on the endoplasmic reticulum, which may facilitate exchange of metabolites between the organelles." [PMID:19556461]


id: GO:1990457
name: pexophagosome
namespace: cellular_component
def:
  "A membrane-bounded intracellular vesicle involved in the degradation of peroxisome by macropexophagy." [PMID:22536249]


id: GO:1990458
name: lipooligosaccharide binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with lipooligosaccharide. Lipooligosaccharides (LOSs) are the major glycolipids expressed on mucosal Gram-negative bacteria." [GOC:hjd, PMID:8894399]


id: GO:1990461
name: detoxification of iron ion
namespace: biological_process
def:
  "Any process that reduces or removes the toxicity of iron ion. These include transport of iron away from sensitive areas and to compartments or complexes whose purpose is sequestration of iron ion." [GOC:sart, PMID:23064556]


id: GO:1990462
name: omegasome
namespace: cellular_component
def:
  "Omega-shaped (as in the Greek capital letter) intracellular membrane-bounded organelle enriched in phosphatidylinositol 3-phosphate and dynamically connected to the endoplasmic reticulum. Omegasomes are the first step of the formation of autophagosomes via the pre-autophagosomal structures." [GOC:autophagy, GOC:mf, PMID:18725538, PMID:24591649]


id: GO:1990463
name: lateral cortical node
namespace: cellular_component
def:
  "A protein complex that is anchored at the cortical face of the plasma membrane, and contains proteins involved in regulating cell cycle progression. In Schizosaccharomyces pombe, lateral cortical nodes are several megadaltons in size, and contain Slf1, which anchors the complex at the membrane, and the methyltransferase Skb1 in stoichiometric quantities, and may contain other proteins." [GOC:mah, PMID:25009287]


id: GO:1990464
name: D-2-hydroxyacid dehydrogenase (quinone) activity
namespace: molecular_function
def:
  "Catalysis of the reaction: (R)-2-hydroxyacid + a quinone = 2-oxoacid + a quinol." [EC:1.1.5.10, GOC:am, PMID:3013300, PMID:4582730]


id: GO:1990465
name: aldehyde oxygenase (deformylating) activity
namespace: molecular_function
def:
  "Catalysis of the reaction a long-chain aldehyde + O(2) + 2 NADPH = an alkane + formate + H(2)O + 2 NADP(+)." [GOC:mengo_curators, PMID:22947199]


id: GO:1990466
name: protein autosumoylation
namespace: biological_process
def:
  "The sumoylation by a protein of one or more of its own amino acid residues, or residues on an identical protein." [PMID:21518767, PMID:23443663]


id: GO:1990467
name: NuA3a histone acetyltransferase complex
namespace: cellular_component
def:
  "A NuA3 complex that catalyzes the acetylation of Histone H3. In S. cerevisiae, this complex consists of Eaf6p, Nto1p, Sas3p, Taf14p, Yng1p and associates with H3K4me3 using Yng1p." [GOC:rb, PMID:25104842]


id: GO:1990468
name: NuA3b histone acetyltransferase complex
namespace: cellular_component
def:
  "A NuA3 complex that catalyzes the acetylation of Histone H3. In S. cerevisiae, this complex consists of Eaf6p, Nto1p, Sas3p, Taf14p, Pdp3 and associates with H3K4me3 via Pdp3p." [GOC:rb, PMID:25104842]


id: GO:1990469
name: Rhino-Deadlock-Cutoff Complex
namespace: cellular_component
def:
  "Protein complex found in Drosophila consisting of the gene products of cuff, del and rhi. It regulates the licensing of transcription of dual-strand PIWI interacting RNA (piRNA) source loci by binding to dual-strand-cluster chromatin, probably via the H3K9me3-binding activity of Rhi. Rhi binding brings the putative termination cofactor Cuff in close proximity to the nascent piRNA precursor transcript which it appears to protect from degradation." [GOC:bhm, IntAct:EBI-9694217, PMID:24906153]


id: GO:1990470
name: piRNA cluster binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with piRNA clusters, double-stranded DNA regions that give rise to PIWI-interacting RNAs (piRNAs)." [GOC:bhm, PMID:24906153]


id: GO:1990471
name: piRNA uni-strand cluster binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with uni-strand piRNA clusters, double-stranded DNA regions that give rise to PIWI-interacting RNAs (piRNAs) that map predominantly to only one strand and exhibit hallmarks of canonical Pol II transcription. Uni-strand piRNA clusters are found in many taxa." [GOC:bhm, PMID:24906153]


id: GO:1990472
name: piRNA dual-strand cluster binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with dual-strand piRNA clusters, double-stranded DNA regions that give rise to PIWI-interacting RNAs (piRNAs) where piRNAs originate from both DNA strands via noncanonical transcription." [GOC:bhm, PMID:24906153]


id: GO:1990473
name: ciliary targeting signal binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with a ciliary targeting sequence, a specific peptide sequence that acts as a signal to localize a membrane protein to the ciliary membrane." [GOC:krc, PMID:18256283, PMID:19575670, PMID:20603001, PMID:20697559]


id: GO:1990474
name: synaptic vesicle, readily releasable pool
namespace: cellular_component
def:
  "A synaptic vesicle belonging to the pool of vesicles that are the first to be released as a result of chemical or electrical stimulation e.g. by an action potential, have the highest presynaptic membrane fusion probability and correspond to about 1% of the total number of synaptic vesicles at a resting terminal bouton." [GOC:pad, PMID:22745285]


id: GO:1990475
name: synaptic vesicle, recycling pool
namespace: cellular_component
def:
  "A synaptic vesicles belonging to the pool that repopulate vacancies within the readily releasable pool (RRP) of synaptic vesicles, and require more significant stimuli than the RRP in order to release neurotransmitter; about 10-15% of the total number of synaptic vesicles at a resting terminal bouton are in this state." [GOC:pad, PMID:22745285]


id: GO:1990476
name: synaptic vesicle, resting pool
namespace: cellular_component
def:
  "A synaptic vesicle belonging to the pool that remain unreleased even after prolonged stimulation  causes a saturating degree of vesicular turnover.  50-80% of the total number of synaptic vesicles at a resting terminal bouton are in this pool." [GOC:pad, PMID:22745285]


id: GO:1990477
name: NURS complex
namespace: cellular_component
def:
  "The nuclear RNA silencing (NURS) complex is a protein complex formed by Red1, Mtl1, Red5, Rmn1, Iss10/Pir1, and Ars2/Pir2 that regulates RNA degradation and histone H3 lysine 9 methylation. It is likely related to the human CBCN complex." [PMID:24713849]


id: GO:1990478
name: response to ultrasound
namespace: biological_process
def:
  "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ultrasonic stimulus." [PMID:20950932]


id: GO:1990479
name: obsolete response to lipoic acid
namespace: biological_process
def:
  "OBSOLETE. Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipoic acid stimulus." [PMID:23232760]


id: GO:1990480
name: obsolete geranyl diphosphate synthase
namespace: molecular_function
def:
  "OBSOLETE. Catalyzes the condensation of dimethylallyl diphosphate and isopentenyl diphosphate to geranyl diphosphate, the key precursor of monoterpene biosynthesis." [GOC:mengo_curators, PMID:10557273]


id: GO:1990482
name: sphingolipid alpha-glucuronosyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: UDP-glucuronate + inositol phosphorylceramide (IPC) = UDP + GlcA-IPC." [GOC:tb, PMID:25122154]


id: GO:1990483
name: Clr6 histone deacetylase complex I''
namespace: cellular_component
def:
  "A histone deacetylase complex involved in chromatin organization. In Schizosaccharomyces pombe this complex consists of Clr6, Nts1, Mug165, and Png3." [PMID:25002536]


id: GO:1990484
name: aerobic lactate catabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the breakdown of lactate (2-hydroxypropanoic acid) in the presence of oxygen." [GOC:mengo_curators, PMID:8941775]


id: GO:1990485
name: anaerobic lactate catabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the breakdown of lactate (2-hydroxypropanoic acid) in the absence of oxygen." [GOC:mengo_curators, PMID:11133436]


id: GO:1990486
name: anaerobic fatty acid catabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the breakdown of a fatty acid in the absence of oxygen. A fatty acid is any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes." [GOC:mengo_curators, PMID:17329794]


id: GO:1990487
name: anaerobic lignin catabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the breakdown of lignin in the absence of oxygen. Lignin is a class of polymers of phenylpropanoid units." [DOI:10.1039/C3EE40932E, GOC:mengo_curators]


id: GO:1990488
name: anaerobic cellulose catabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the breakdown of cellulose, a linear beta1-4 glucan of molecular mass 50-400 kDa with the pyranose units in the -4C1 conformation, in absence of oxygen." [GOC:mengo_curators, PMID:8561466]


id: GO:1990489
name: anaerobic pectin catabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the breakdown of pectin, a polymer containing a backbone of alpha-1,4-linked D-galacturonic acid residues, in the absence of oxygen." [GOC:mengo_curators, PMID:23079077]


id: GO:1990490
name: archaeal proton-transporting A-type ATPase complex
namespace: cellular_component
def:
  "A large proton-transporting two-sector ATPase protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of protons across a membrane and is found in Archaea." [GOC:mengo_curators, PMID:15473999, PMID:24650628]


id: GO:1990491
name: methane biosynthetic process from methanol and hydrogen
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of methane from methanol and hydrogen." [GOC:mengo_curators, PMID:16347126]


id: GO:1990492
name: mitotic cell cycle checkpoint inhibiting CAR assembly
namespace: biological_process
def:
  "A Mad2-dependent mitotic cell cycle checkpoint which delays cytokinetic actinomycin ring assembly if there is a delay in early M-phase." [PMID:12186944]


id: GO:1990493
name: obsolete cyclin H-CDK7 complex
namespace: cellular_component
def:
  "OBSOLETE. A protein complex consisting of cyclin H and cyclin-dependent kinase 7 (CDK7). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner." [PMID:9857180]


id: GO:1990494
name: obsolete regulation of mitotic cytokinesis, actomyosin contractile ring assembly
namespace: biological_process
def:
  "OBSOLETE. Any process that modulates the frequency, rate or extent of mitotic cytokinesis, actomyosin contractile ring assembly." [PMID:18256290]


id: GO:1990495
namespace: biological_process
name:
  obsolete actin filament organization involved in mitotic cytokinetic actomyosin contractile ring assembly

def:
  "OBSOLETE. An actin filament organization process that contributes to actomyosin contractile ring assembly during mitotic cytokinesis." [PMID:8834798]


id: GO:1990496
namespace: biological_process
name:
  obsolete regulation of actin filament organization involved in mitotic cytokinetic actomyosin contractile ring assembly

def:
  "OBSOLETE. An actin filament organization process that contributes to regulation of actomyosin contractile ring assembly during mitotic cytokinesis." [PMID:24798735]


id: GO:1990497
name: regulation of cytoplasmic translation in response to stress
namespace: biological_process
def:
  "Modulation of the frequency, rate or extent of cytoplasmic translation as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:vw, PMID:16278445]


id: GO:1990499
name: raps-insc complex
namespace: cellular_component
def:
  "Protein complex required for the asymmetric division of neuroblasts in Drosophila. Coordinates asymmetric localization of cell fate determinants with orientation of the mitotic spindle resulting in different daughter cells upon division. Localizes at the apical cortex of the neuroblast: Raps maintains, but does not initiate, Insc apically, while Insc segregates Raps asymmetrically. Complex appears to be conserved in mammals (composed of INSC and GPSM1 or GPSM2)." [GOC:bhm, IntAct:EBI-9674411, PMID:22171003]


id: GO:1990500
name: eif4e-cup complex
namespace: cellular_component
def:
  "A protein complex that causes translational repression in Drosophila. Prevents assembly of ribosomes at the mRNA by interfacing with a sequence-specific RNA-binding protein leading to recruitment of the CCR4 complex and consequently, reduction of the mRNA's poly(A) tail length. The complex is also required for dorso-ventral pattern formation in the embryo." [GOC:bhm, IntAct:EBI-9674930, PMID:14723848]


id: GO:1990501
name: exon-exon junction subcomplex mago-y14
namespace: cellular_component
def:
  "Component of the core exon-exon-junction complex (EJC). Fairly conserved in eukaryotes; in Drosophila, consists of the Mago and Y14 (tsunagi) gene products. Important for coupling nuclear and cytoplasmic events in gene expression. Inhibits the ATPase activity of eIF4AIII (Q9VHS8) to ensure a stable association of the EJC core with the mRNA." [GOC:bhm, IntAct:EBI-9549962, PMID:12730685]


id: GO:1990502
name: dense core granule maturation
namespace: biological_process
def:
  "Steps required to transform a dense core granule generated at the trans-Golgi network into a fully formed and transmissible dense core granule. Dense core granule maturation proceeds through clathrin-mediated membrane remodeling events and is essential for efficient processing of cargo within dense core granules as well as for removing factors that might otherwise interfere with dense core granule trafficking and exocytosis." [GOC:kmv, PMID:22654674]


id: GO:1990503
name: dendritic lamellar body
namespace: cellular_component
def:
  "A specialized secretory organelle found in neurons and associated with the formation of dendrodendritic gap junctions." [PMID:7869120]


id: GO:1990504
name: dense core granule exocytosis
namespace: biological_process
def:
  "The secretion of molecules (e.g. neuropeptides, insulin-related peptides or neuromodulators such as serotonin and dopamine) contained within a membrane-bounced dense core granule by fusion of the granule with the plasma membrane of a cell in response to increased cytosolic calcium levels." [GOC:kmv, PMID:17553987, PMID:24653208]


id: GO:1990505
name: mitotic DNA replication maintenance of fidelity
namespace: biological_process
def:
  "Any maintenance of fidelity that is involved in mitotic cell cycle DNA replication." [PMID:19185548]


id: GO:1990506
name: mitotic DNA-dependent DNA replication
namespace: biological_process
def:
  "A DNA replication process that uses parental DNA as a template for the DNA-dependent DNA polymerases that synthesize the new strands during the mitotic cell cycle." [PMID:16120966]


id: GO:1990507
name: ATP-independent chaperone mediated protein folding
namespace: biological_process
def:
  "The process of inhibiting aggregation and assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure that is dependent on interaction with a chaperone, and independent of ATP hydrolysis." [GOC:rb, PMID:25242142]


id: GO:1990508
name: CKM complex
namespace: cellular_component
def:
  "Cyclin-dependent kinase complex which reversibly associates with the Mediator complex. In Saccharomyces cerevisiae it consists of SSN2, SSN3, SSN8 and SRB8." [GOC:bhm, IntAct:EBI-2640924, PMID:12200444]


id: GO:1990509
name: PYM-mago-Y14 complex
namespace: cellular_component
def:
  "Protein complex involved in the disassembly of Mago-Y14 from the spliced mRNA during first round of translation, independently of the translational machinery. Conserved from fission yeast to humans." [GOC:bhm, IntAct:EBI-9634190, PMID:14968132]


id: GO:1990511
name: piRNA biosynthetic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of piRNAs, Piwi-associated RNAs, a class of 24- to 30-nucleotide RNA derived from repeat or complex DNA sequence elements and processed by a Dicer-independent mechanism." [PMID:24696457]


id: GO:1990512
name: Cry-Per complex
namespace: cellular_component
def:
  "Nuclear transcriptional repressor complex that is capable of negatively regulating CLOCK-BMAL-dependent transactivation of genes in a delayed negative feedback manner which generates circadian rhythms." [GOC:bhm, IntAct:EBI-9693126, IntAct:EBI-9693260, IntAct:EBI-9694282, IntAct:EBI-9695878, IntAct:EBI-9695921, IntAct:EBI-9695942, IntAct:EBI-9696219, IntAct:EBI-9696270, IntAct:EBI-9696293, IntAct:EBI-9696310, IntAct:EBI-9696328, IntAct:EBI-9696345, PMID:24855952]


id: GO:1990513
name: CLOCK-BMAL transcription complex
namespace: cellular_component
def:
  "Transcription factor complex which interacts with E-box regulatory elements in target genes, including Period (Per1, Per2, Per3) and Cryptochrome (Cry1, Cry2), to activate their transcription during the daytime. The CRY-PER complexes inhibit CLOCK-BMAL1-driven transcription in a negative feedback loop to generate circadian rhythms." [GOC:bhm, IntAct:EBI-9696362, IntAct:EBI-9696901, IntAct:EBI-9696921, IntAct:EBI-9696951, PMID:23229515]


id: GO:1990514
name: 5' transitive RNA interference
namespace: biological_process
def:
  "An RNA interference where the silencing signal spreads 5' along the target mRNA, outside of the initial target sequence. Typically involves the formation of secondary siRNAs formed when the initial mRNA target sequence functions as a template for 5' to 3' synthesis of new dsRNA." [GOC:pf, PMID:24369430]


id: GO:1990515
name: 3' transitive RNA interference
namespace: biological_process
def:
  "An RNA interference where the silencing signal spreads 3' along the target mRNA, outside of the initial target sequence. Typically involves the formation of secondary siRNAs formed when the initial mRNA target sequence functions as a template for 5' to 3' synthesis of new dsRNA." [GOC:pf, PMID:24369430]


id: GO:1990516
name: ribonucleotide excision repair
namespace: biological_process
def:
  "The pathway by which a ribonucleotide is removed from DNA and replaced by a deoxyribonucleotide. The ribonucleotide is incised by RNase H2, and further excised by an endonuclease. The resulting 1 nt gap is then repaired by DNA polymerase and DNA ligase." [PMID:12475934, PMID:22864116]


id: GO:1990517
name: obsolete protein localization to photoreceptor outer segment
namespace: biological_process
def:
  "OBSOLETE. A process in which a protein is transported to, or maintained in, a location within a photoreceptor outer segment, which is a portion of a modified sensory cilium." [GOC:krc, PMID:20212494]


id: GO:1990518
name: single-stranded DNA-dependent ATP-dependent 3'-5' DNA helicase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: ATP + H2O = ADP + phosphate, in the presence of single-stranded DNA; drives the unwinding of the DNA helix in the direction 3' to 5'." [PMID:25165823]


id: GO:1990519
name: mitochondrial pyrimidine nucleotide import
namespace: biological_process
def:
  "The directed movement of a pyrimidine nucleotide across the mitochondrial outer membrane into the mitochondria." [PMID:16194150]


id: GO:1990520
name: separase-securin complex
namespace: cellular_component
def:
  "A protein complex that includes separase and securin as components and that inhibits chromosome separation at mitosis." [GOC:dos, GOC:vw, PMID:8978688]


id: GO:1990522
name: tail spike morphogenesis
namespace: biological_process
def:
  "The process in which the nematode tail spike is generated and organized. An example of this process is seen in C. elegans, where the tapered tail spike is formed during embryogenesis by a filamentous process that passes posteriorly through hyp10, the tail ventral hypodermis; the filamentous process is formed by a binucleate cell, the tail-spike cell, that subsequently undergoes programmed cell death." [GOC:kmv, PMID:17329362, PMID:6684600]


id: GO:1990524
name: INA complex
namespace: cellular_component
def:
  "A protein complex located in the inner membrane of mitochondria that is involved in the assembly of the peripheral (or stator) stalk of the mitochondrial proton-transporting ATP synthase (also known as the F1F0 ATP synthase). In budding yeast, this complex includes Ina22p and Ina17p." [GOC:rn, PMID:24942160]


id: GO:1990525
name: BIR domain binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with a Baculovirus Inhibitor of apoptosis protein Repeat (BIR) domain." [GOC:ha, InterPro:IPR001370]


id: GO:1990526
name: Ste12p-Dig1p-Dig2p complex
namespace: cellular_component
def:
  "A multiprotein complex that is involved in the transcription regulation of mating genes in the yeast S. cerevisiae." [GOC:rb, PMID:16782869]


id: GO:1990528
name: Rvs161p-Rvs167p complex
namespace: cellular_component
def:
  "A protein complex that is involved in endocytosis in the yeast S. cerevisiae." [GOC:rb, PMID:20610658]


id: GO:1990529
name: glycosylphosphatidylinositol-mannosyltransferase I complex
namespace: cellular_component
def:
  "A protein complex that is involved in the transfer of the four mannoses in the GPI-anchor precursor. In yeast S. cerevisiae this complex consists of Pbn1p and Gpi14p and in rat this complex consists of PIG-X and PIG-M." [GOC:dph, GOC:rb, PMID:15635094]


id: GO:1990530
name: Cdc50p-Drs2p complex
namespace: cellular_component
def:
  "A protein complex that assembles on the ER membrane and is essential for the ER exit of the Cdc50p-Drs2p complex." [GOC:rb, PMID:15090616]


id: GO:1990531
name: Lem3p-Dnf1p complex
namespace: cellular_component
def:
  "A protein complex that functions as a phospholipid-translocating P-Type ATPase." [GOC:dph, GOC:rb, PMID:15090616]


id: GO:1990532
name: stress response to nickel ion
namespace: biological_process
def:
  "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis caused by a nickel ion stimulus." [PMID:25330323]


id: GO:1990533
name: Dom34-Hbs1 complex
namespace: cellular_component
def:
  "A protein complex consisting of one subunit known as Dom34 or Pelota that has similarity to translation termination factor eRF1, and another subunit, Hbs1, that is a GTPase with similarity to translation termination factor eRF3. The Dom34-Hbs1 complex has a role in cotranslational mRNA quality control by promoting ribosomal subunit dissociation and peptidyl-tRNA release when translation is stalled, facilitating no-go decay and nonstop decay." [GOC:mcc, PMID:20890290, PMID:21102444, PMID:21448132, PMID:22503425]


id: GO:1990534
name: thermospermine oxidase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: S-methyl-5'-thioadenosine + thermospermine + H+ = S-adenosyl 3-(methylthio)propylamine + spermidine." [PMID:24906355]


id: GO:1990535
name: neuron projection maintenance
namespace: biological_process
def:
  "The organization process that preserves a neuron projection in a stable functional or structural state. A neuron projection is a prolongation or process extending from a nerve cell, e.g. an axon or dendrite." [PMID:25359212]


id: GO:1990536
name: phosphoenolpyruvate transmembrane import into Golgi lumen
namespace: biological_process
def:
  "The directed movement of phosphoenolpyruvate into the Golgi lumen across the Golgi membrane." [PMID:25195688]


id: GO:1990537
name: mitotic spindle polar microtubule
namespace: cellular_component
def:
  "Any of the mitotic spindle microtubules that come from each pole and overlap at the spindle midzone." [PMID:16079915]


id: GO:1990539
name: fructose import across plasma membrane
namespace: biological_process
def:
  "The directed movement of fructose substance from outside of a cell, across the plasma membrane and into the cytosol." [PMID:10735857]


id: GO:1990540
name: mitochondrial manganese ion transmembrane transport
namespace: biological_process
def:
  "A process in which a manganese ion is transported from one side of a mitochondrial membrane to the other by means of some agent such as a transporter or pore." [PMID:12890866]


id: GO:1990541
name: mitochondrial citrate transmembrane transport
namespace: biological_process
def:
  "The directed movement of citrate, 2-hydroxy-1,2,3-propanetricarboyxlate, from one side of a membrane to the other into, out of or within a mitochondrion." [PMID:20371607]


id: GO:1990542
name: mitochondrial transmembrane transport
namespace: biological_process
def:
  "The process in which a solute is transported from one side of a membrane to the other into, out of or within a mitochondrion." [PMID:20533899]


id: GO:1990543
name: mitochondrial S-adenosyl-L-methionine transmembrane transport
namespace: biological_process
def:
  "The directed movement of S-adenosyl-L-methionine from one side of a membrane to the other into, out of or within a mitochondrion." [PMID:14609944]


id: GO:1990544
name: mitochondrial ATP transmembrane transport
namespace: biological_process
def:
  "The directed movement of ATP from one side of a membrane to the other into, out of or within a mitochondrion." [PMID:18485069]


id: GO:1990545
name: mitochondrial thiamine pyrophosphate transmembrane transport
namespace: biological_process
def:
  "The directed movement of thiamine pyrophosphate from one side of a membrane to the other into, out of or within a mitochondrion." [PMID:12411483]


id: GO:1990546
name: mitochondrial tricarboxylic acid transmembrane transport
namespace: biological_process
def:
  "The directed movement of a tricarboxylic acid from one side of a membrane to the other into, out of or within a mitochondrion." [GOC:vw]


id: GO:1990547
name: mitochondrial phosphate ion transmembrane transport
namespace: biological_process
def:
  "The directed movement of phosphate ion from one side of a membrane to the other into, out of or within a mitochondrion." [PMID:9099701]


id: GO:1990548
name: mitochondrial FAD transmembrane transport
namespace: biological_process
def:
  "The directed movement of FAD from one side of a membrane to the other into, out of or within a mitochondrion." [PMID:14555654]


id: GO:1990549
name: mitochondrial NAD transmembrane transport
namespace: biological_process
def:
  "The directed movement of NAD from one side of a membrane to the other into, out of or within a mitochondrion." [PMID:16291748]


id: GO:1990550
name: mitochondrial alpha-ketoglutarate transmembrane transport
namespace: biological_process
def:
  "The directed movement of alpha-ketoglutarate from one side of a membrane to the other into, out of or within a mitochondrion." [PMID:11013234, PMID:20371607]


id: GO:1990551
name: mitochondrial 2-oxoadipate transmembrane transport
namespace: biological_process
def:
  "The directed movement of 2-oxoadipate from one side of a membrane to the other into, out of or within a mitochondrion." [PMID:11013234]


id: GO:1990553
name: mitochondrial 5'-adenylyl sulfate transmembrane transport
namespace: biological_process
def:
  "The directed movement of 5'-adenylyl sulfate from one side of a membrane to the other into, out of or within a mitochondrion." [PMID:24296033]


id: GO:1990554
name: mitochondrial 3'-phospho-5'-adenylyl sulfate transmembrane transport
namespace: biological_process
def:
  "The directed movement of 3'-phospho-5'-adenylyl sulfate from one side of a membrane to the other into, out of or within a mitochondrion." [PMID:24296033]


id: GO:1990555
name: mitochondrial oxaloacetate transmembrane transport
namespace: biological_process
def:
  "The directed movement of oxaloacetate from one side of a membrane to the other into, out of or within a mitochondrion." [PMID:10428783]


id: GO:1990556
name: mitochondrial isopropylmalate transmembrane transport
namespace: biological_process
def:
  "The directed movement of isopropylmalate from one side of a membrane to the other into, out of or within a mitochondrion." [PMID:10428783]


id: GO:1990557
name: mitochondrial sulfate transmembrane transport
namespace: biological_process
def:
  "The directed movement of sulfate from one side of a membrane to the other into, out of or within a mitochondrion." [PMID:10428783]


id: GO:1990558
name: mitochondrial malonate(1-) transmembrane transport
namespace: biological_process
def:
  "The directed movement of malonate(1-) from one side of a membrane to the other into, out of or within a mitochondrion." [PMID:10428783]


id: GO:1990559
name: mitochondrial coenzyme A transmembrane transport
namespace: biological_process
def:
  "The directed movement of coenzyme A from one side of a membrane to the other into, out of or within a mitochondrion." [PMID:11158296]


id: GO:1990560
name: obsolete DNA methyltransferase binding
namespace: molecular_function
def:
  "OBSOLETE. Interacting selectively and non-covalently with a DNA methyltransferase." [PMID:22880885]


id: GO:1990561
name: regulation of transcription from RNA polymerase II promoter in response to copper ion starvation
namespace: biological_process
def:
  "Modulation of the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a stimulus indicating the organism is deprived of copper ions." [GOC:al, PMID:10593913]


id: GO:1990562
name: syndecan-syntenin-ALIX complex
namespace: cellular_component
def:
  "An exosome complex that is assembled in the multivesicular body (MVB) membrane and chaperoned to the exosome by the ESCRT-III machinery." [GOC:bhm, IntAct:EBI-9985210, IntAct:EBI-9985797, PMID:22660413]


id: GO:1990563
name: extracellular exosome complex
namespace: cellular_component
def:
  "A protein complex that is wholly or partially contained within the lumen or membrane of the extracellular vesicular exosome." [GOC:bhm, IntAct:EBI-9985210, IntAct:EBI-9985797, PMID:22660413]


id: GO:1990564
name: protein polyufmylation
namespace: biological_process
def:
  "Covalent attachment of the ubiquitin-like protein UFM1 to a protein, forming an UFM1 chain." [PMID:25219498]


id: GO:1990565
name: HSP90-CDC37 chaperone complex
namespace: cellular_component
def:
  "A protein complex involved in stress-induced mitophagy (mitochondrial degradation). In mammals it consists of heat shock protein HSP90 and its co-chaperone CDC37. Experimental evidence suggests that the complex enables the autophosphorylation of ULK1. Phosphorylated ULK1 in turn phosphorylates ATG13 which is an essential step in mitophagy. HSP90-CDC37 binding prevents rapid ubiquitin-dependent proteosomal degradation of its targets." [GOC:bhm, GOC:pad, GOC:PARL, IntAct:EBI-9990131, IntAct:EBI-9990540, PMID:21855797, PMID:22939624]


id: GO:1990566
name: I(KACh) inward rectifier potassium channel complex
namespace: cellular_component
def:
  "An inward rectifier potassium channel complex expressed in cardiac muscle, specifically the sinoatrial node and atria, where it controls the heart rate, via regulation by G-protein-coupled receptor signalling. In mammals it is composed of GIRK1 (or Kir3.1) and GIRK4 (or Kir3.4) subunits." [GOC:ame, IntAct:EBI-9975539, PMID:9765280]


id: GO:1990567
name: DPS complex
namespace: cellular_component
def:
  "A protein serine/threonine phosphatase complex that in S. pombe consists of the proteins Dis2, Ppn1, and Swd22." [PMID:24945319]


id: GO:1990568
name: obsolete MIS18 complex
namespace: cellular_component
def:
  "OBSOLETE. A centromere complex assembly protein that is required for the deposition of CENP-A on the centromere. The Mis18 complex localizes to centromeres just prior to the pre-nucleosomal HJURP/CENP-A/H4 complex and is absolutely required for the CENP-A-specific chaperone, Holliday junction recognition protein (HJURP) to reach the centromeres. Plk1 phosphorylation activates Mis18 complex recruitment to the centromeres during G1. CDK phosphorylation of MISBP1 during G2 and mitosis, prior to the metaphase-to-anaphase transition, negatively regulates complex assembly." [GOC:bhm, IntAct:EBI-9872194, IntAct:EBI-9873644, PMID:25036634]


id: GO:1990571
name: meiotic centromere clustering
namespace: biological_process
def:
  "The process by which centromeres/kinetochores become localized to clusters during a meiotic nuclear division. For example, in Schizosaccharomyces pombe, centromeres are located in one or two clusters away from the spindle pole body during meiosis." [PMID:10366596, PMID:9009280]


id: GO:1990572
name: TERT-RMRP complex
namespace: cellular_component
def:
  "A ribonucleoprotein complex that has RNA-directed RNA polymerase (RdRP) activity, and is composed of telomerase reverse transcriptase (TERT) and the non-coding RNA component of mitochondrial RNA processing endoribonuclease (RMRP)." [GOC:bf, GOC:BHF, GOC:nc, PMID:19701182]


id: GO:1990573
name: potassium ion import across plasma membrane
namespace: biological_process
def:
  "The directed movement of potassium ions from outside of a cell, across the plasma membrane and into the cytosol." [PMID:9139127]


id: GO:1990574
name: meiotic spindle astral microtubule
namespace: cellular_component
def:
  "Any of the meiotic spindle microtubules that radiate in all directions from the spindle poles and are thought to contribute to the forces that separate the poles and position them in relation to the rest of the cell." [PMID:10366596]


id: GO:1990575
name: mitochondrial L-ornithine transmembrane transport
namespace: biological_process
def:
  "The directed movement of L-ornithine from one side of a membrane to the other into, out of or within a mitochondrion." [PMID:9237680]


id: GO:1990576
name: G-protein coupled glucose receptor activity
namespace: molecular_function
def:
  "Combining with an extracellular glucose molecule and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [PMID:15667320]


id: GO:1990578
name: perinuclear endoplasmic reticulum membrane
namespace: cellular_component
def:
  "The membrane of the perinuclear endoplasmic reticulum, which is the portion of endoplasmic reticulum, the intracellular network of tubules and cisternae, that occurs near the nucleus." [PMID:25454947]


id: GO:1990579
name: peptidyl-serine trans-autophosphorylation
namespace: biological_process
def:
  "The phosphorylation of a peptidyl-serine to form peptidyl-O-phospho-L-serine on an identical protein. For example, phosphorylation by the other kinase within a homodimer." [GOC:bf, GOC:PARL, PMID:21317875]


id: GO:1990580
name: regulation of cytoplasmic translational termination
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of cytoplasmic translational termination." [PMID:11570975]


id: GO:1990581
name: obsolete lysosome lysis
namespace: biological_process
def:
  "OBSOLETE. The rupture of the lysosomal membrane and loss of contents as a result of osmotic change, G-protein-driven disintegration, or unspecified cause." [PMID:24472, PMID:9538255]


id: GO:1990582
name: obsolete intracellular membrane-bounded organelle binding
namespace: molecular_function
def:
  "OBSOLETE. The temporary binding of a protein or protein complex to the membrane of an intracellular membrane-bounded organelle." [PMID:16100119, PMID:9538255]


id: GO:1990584
name: cardiac Troponin complex
namespace: cellular_component
def:
  "A complex of accessory proteins (cardiac troponin T, cardiac troponin I and cardiac troponin C) found associated with actin in cardiac muscle thin filaments; involved in calcium regulation important for muscle contraction." [GOC:ame, IntAct:EBI-9980814, PMID:12840750]


id: GO:1990585
name: hydroxyproline O-arabinosyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: UDP-beta-L-arabinofuranose + a [protein]-trans-4-hydroxy-L-proline <=> a protein-O-(beta-L-arabinofuranose)-trans-4-hydroxy-L-proline + UDP + H+." [EC:2.4.2, PMID:24036508]


id: GO:1990586
name: divisome complex
namespace: cellular_component
def:
  "A protein complex required for prokaryotic cell division (FtsZ-dependent cytokinesis). These complexes are assembled and recruited to the cell septum in a strictly controlled sequence and co-ordinate invagination of the cell membrane, inward growth of the peptidoglycan layer, constriction of the outer membrane and separation of daughter cells." [GOC:bhm, IntAct:EBI-9547109, IntAct:EBI-9997581, PMID:15165235, PMID:21784946]


id: GO:1990587
name: FtsQBL complex
namespace: cellular_component
def:
  "A protein complex required for prokaryotic cell division (FtsZ-dependent cytokinesis). Part of the divisome. Assembled independently of the other divisome components in the cytoplasm prior to transport to the cell septum. In E. coli consists of FtsB, FtsL and FtsQ." [GOC:bhm, IntAct:EBI-9997581, PMID:15165235, PMID:21784946]


id: GO:1990588
name: FtsBL complex
namespace: cellular_component
def:
  "A protein complex required for prokaryotic cell division (FtsZ-dependent cytokinesis). Part of the divisome. Assembled independently of the other divisome components in the cytoplasm prior to transport to the cell septum. In E. coli consists of FtsB and FtsL." [GOC:bhm, IntAct:EBI-9997581, PMID:15165235, PMID:21784946]


id: GO:1990589
name: ATF4-CREB1 transcription factor complex
namespace: cellular_component
def:
  "Transcription factor complex consisting of ATF4 and CREB1 subunits that is capable of binding to cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3') as part of the positive regulation of transcription. Regulatory targets include the GRP78 (HSPA5) promoter in humans, whose activation by this complex is part of the ER stress response pathway." [GOC:bhm, IntAct:EBI-10043081, IntAct:EBI-10043332, PMID:12871976]


id: GO:1990590
name: ATF1-ATF4 transcription factor complex
namespace: cellular_component
def:
  "Transcription factor complex consisting of ATF1 and ATF4 subunits that is capable of binding to cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3') of the GRP78 (HSPA5) promoter. Involved in the ER stress response pathway." [GOC:bhm, IntAct:EBI-10043123, IntAct:EBI-10043370, PMID:12871976]


id: GO:1990591
name: asparagine transmembrane import into vacuole
namespace: biological_process
def:
  "The directed movement of asparagine into the vacuole across the vacuolar membrane." [PMID:20388511]


id: GO:1990592
name: protein K69-linked ufmylation
namespace: biological_process
def:
  "A protein ufmylation process in which a polymer of the ubiquitin-like protein UFM1 is formed by linkages between lysine residues at position 69 of the UFM1 monomers, is added to a protein." [PMID:25219498]


id: GO:1990593
name: nascent polypeptide-associated complex binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with the nascent polypeptide-associated complex, which is a heterodimeric protein complex that can reversibly bind to ribosomes and is located in direct proximity to newly synthesized polypeptide chains as they emerge from the ribosome." [PMID:25487825]


id: GO:1990595
name: mast cell secretagogue receptor activity
namespace: molecular_function
def:
  "Combining with basic secretagogues to initiate pseudo-allergic reactions in mast cells." [GOC:sp, PMID:25517090]


id: GO:1990596
name: histone H3-K4 deacetylation
namespace: biological_process
def:
  "The modification of histone H3 by the removal of an acetyl group from lysine at position 4 of the histone." [PMID:20299449]


id: GO:1990597
name: AIP1-IRE1 complex
namespace: cellular_component
def:
  "A protein complex consisting of IRE1 (inositol-requiring enzyme-1) bound to AIP1 (ASK1-interacting protein 1/DAB2-interacting protein)." [GOC:bf, GOC:PARL, PMID:18281285]


id: GO:1990598
name: repair of mitotic mono-orientation defects
namespace: biological_process
def:
  "The mitotic cell cycle process where mono-orientation defects are corrected in order to ensure sister chromatids establish stable attachments to microtubules emanating from opposite spindle poles." [GOC:mtg_cell_cycle, GOC:vw, PMID:15525536]


id: GO:1990599
name: 3' overhang single-stranded DNA endodeoxyribonuclease activity
namespace: molecular_function
def:
  "Catalysis of the hydrolysis of ester linkages within 3' overhang single-stranded deoxyribonucleic acid by creating internal breaks." [PMID:25203555]


id: GO:1990600
name: single-stranded DNA endodeoxyribonuclease activator activity
namespace: molecular_function
def:
  "Increases the activity of a single-stranded DNA endodeoxyribonuclease activator activity." [PMID:25203555]


id: GO:1990601
name: 5' overhang single-stranded DNA endodeoxyribonuclease activity
namespace: molecular_function
def:
  "Catalysis of the hydrolysis of ester linkages within 5' overhang single-stranded deoxyribonucleic acid by creating internal breaks." [PMID:25203555]


id: GO:1990602
name: importin alpha-subunit nuclear import complex
namespace: cellular_component
def:
  "A trimeric protein complex which functions to shuttle the importin alpha-subunit into the nucleus through the nuclear pore to facilitate another round of mRNP incorporation and regulation. In Drosophila it consists of Cdm (Imp13), Mago and Tsu (Y14)." [GOC:bhm, IntAct:EBI-9673795, PMID:20122403]


id: GO:1990603
name: dark adaptation
namespace: biological_process
def:
  "The process by which the rods of the retina gradually become fully responsive to dim light when no longer exposed to bright light." [GOC:hjd, http://www.ncbi.nlm.nih.gov/books/NBK11525/, ISBN:0198506732]


id: GO:1990604
name: IRE1-TRAF2-ASK1 complex
namespace: cellular_component
def:
  "A protein complex of the endoplasmic reticulum membrane that consists of IRE1 (Inositol-requiring enzyme-1), TRAF2 (TNF receptor-associated factor 2) and ASK1 (Apoptosis signal-regulating kinase 1, a MAP3K)." [GOC:bf, GOC:PARL, PMID:12050113, PMID:23000344]


id: GO:1990605
name: GU repeat RNA binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with an RNA molecule containing GU repeats." [PMID:20081200]


id: GO:1990606
name: membrane scission GTPase motor activity
namespace: molecular_function
def:
  "Catalysis of the generation of a 'twisting' activity resulting in the scission of a membrane, coupled to the hydrolysis of a nucleoside triphosphate." [PMID:11242086, PMID:23530241, PMID:24515348]


id: GO:1990607
name: obsolete detection of stimulus involved in cytokinesis after mitosis checkpoint
namespace: biological_process
def:
  "OBSOLETE. The series of events in which information about whether cytokinesis has correctly completed, is received and converted into a molecular signal, contributing to a cytokinesis after mitosis checkpoint." [GOC:mtg_cell_cycle, GOC:vw, PMID:1234]


id: GO:1990608
name: mitotic spindle pole body localization to nuclear envelope
namespace: biological_process
def:
  "A process in which a mitotic spindle pole body is transported to, or maintained in, a specific location in the nuclear envelope." [PMID:24963130]


id: GO:1990611
name: regulation of cytoplasmic translational initiation in response to stress
namespace: biological_process
def:
  "Modulation of the frequency, rate or extent of cytoplasmic translational initiation as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [PMID:16278445]


id: GO:1990612
name: Sad1-Kms2 LINC complex
namespace: cellular_component
def:
  "A LINC complex implicated in the connection of DNA double strand breaks to the cytoskeleton during DNA double-strand break repair." [GOC:vw, PMID:24947240]


id: GO:1990614
name: mitochondrial magnesium ion transmembrane transport
namespace: biological_process
def:
  "A process in which a magnesium ion is transported from one side of a mitochondrial membrane to the other by means of some agent such as a transporter or pore." [PMID:11254124]


id: GO:1990615
name: Kelch-containing formin regulatory complex
namespace: cellular_component
def:
  "A protein complex that regulates actin cable formation, polarized cell growth, and cytokinesis in a formin-dependent manner. In S. cerevisiae the complex is composed of Bud14p and two Kelch family proteins, Kel1p and Kel2p." [PMID:24828508]


id: GO:1990616
name: magnesium ion export from mitochondrion
namespace: biological_process
def:
  "The directed movement of magnesium ions out of mitochondria into the cytosol by means of some agent such as a transporter or pore." [PMID:25585246]


id: GO:1990617
name: CHOP-ATF4 complex
namespace: cellular_component
def:
  "A heterodimeric transcription factor complex that is composed of CHOP (C/EBP homology protein, GADD153) and ATF4 (activating transcription factor 4, also known as cAMP response element binding protein-2/CREB-2) subunits." [GOC:bf, GOC:PARL, PMID:18940792]


id: GO:1990618
name: obsolete ANPR-A:ANP complex
namespace: cellular_component
def:
  "OBSOLETE. The ANPR-A:ANP complex is composed of the hormone AMP bound to the extracellular domain of ANPR-A domain. It is formed in the atrium in response to atrial distension (high blood volume) and leads to guanylate cyclase activity of the ANPR-A receptor, thereby elevating intracellular cGMP levels. The end result is a reduction in blood volume and, therefore, a reduction in cardiac output and systemic blood pressure. Therefore, ANPR-A:ANP complex plays a major role in the regulation of blood pressure and salt-fluid volume homeostasis." [GOC:ame, IntAct:EBI-10093340, PMID:15117952]


id: GO:1990619
name: histone H3-K9 deacetylation
namespace: biological_process
def:
  "The modification of histone H3 by the removal of an acetyl group from lysine at position 9 of the histone." [PMID:25002536]


id: GO:1990620
name: ANPR-A receptor complex
namespace: cellular_component
def:
  "A receptor complex composed of two ANPR-A molecules and expressed in the heart atrium in mammals; it plays a major role in the regulation of blood pressure and salt-fluid volume homeostasis. Binding of the ligand AMP in response to atrial distension (high blood volume) leads to guanylate cyclase activity of the ANPR-A receptor complex, thereby elevating intracellular cGMP levels. The end result is a reduction in blood volume and, therefore, a reduction in cardiac output and systemic blood pressure." [GOC:ame, IntAct:EBI-10093340, PMID:15117952]


id: GO:1990621
name: Vps4-Vta1 complex
namespace: cellular_component
def:
  "A protein complex involved in ESCRT-mediated intralumenal vesicle formation. The complex catalyzes disassembly of the ESCRT-III filament around the neck of the budding vesicle in an ATP-driven reaction, resulting in membrane scission and recycling of the ESCRT-III components back to the cytosol. In yeast, it is formed by the AAA ATPase Vps4 and its cofactor Vta1." [GOC:ha, PMID:20653365, PMID:20696398, PMID:25164817]


id: GO:1990622
name: CHOP-ATF3 complex
namespace: cellular_component
def:
  "A heterodimeric protein complex that is composed of CHOP (C/EBP homology protein, GADD153) and ATF3 (activating transcription factor 3) subunits." [GOC:bf, GOC:PARL, PMID:8622660]


id: GO:1990623
name: Herring body
namespace: cellular_component
def:
  "The dilated terminal portions of neurosecretory axons constituting the hypothalamohypophyseal tract, found in close proximity to sinusoidal capillaries in the posterior pituitary. Herring bodies consist of aggregates of membrane-bound neurosecretory vesicles where oxytocin or antidiuretic hormone (ADH) are stored prior to release. Each Herring body also contains ATP and either neurophysin I or neurophysin II which bind to oxytocin and ADH, respectively." [http://en.wikipedia.org/wiki/Herring_bodies, ISBN:0199652473]


id: GO:1990624
name: guanyl nucleotide exchange factor inhibitor activity
namespace: molecular_function
def:
  "Stops, prevents or reduces the activity of a guanyl nucleotide exchange factor." [GOC:vw, PMID:25635048]


id: GO:1990625
name: negative regulation of cytoplasmic translational initiation in response to stress
namespace: biological_process
def:
  "Any process that stops, prevents or reduces the rate of cytoplasmic translation initiation as a result of a stimulus indicating the organism is under stress." [GOC:vw, PMID:12242291]


id: GO:1990626
name: mitochondrial outer membrane fusion
namespace: biological_process
def:
  "The membrane organization process that joins two mitochondrial outer membranes to form a single membrane." [GOC:vw, PMID:21385840]


id: GO:1990627
name: mitochondrial inner membrane fusion
namespace: biological_process
def:
  "The membrane organization process that joins two mitochondrial outer membranes to form a single membrane." [GOC:vw, PMID:17055438]


id: GO:1990628
name: obsolete Sigma-E factor negative regulation complex
namespace: cellular_component
def:
  "OBSOLETE. A protein complex consisting of RseA, RseB and RpoE. It form the inactive form of the sigma-E transcription factor. In response to stress, outer membrane proteins accumulate in the periplasm and activate cleavage of RseA periplasmic domain by DegS, triggering a proteolytic cascade that frees sigma-E to activate gene expression. RseB binding to RseA prevents activated DegS from cleaving RseA. Sigma-E-mediated envelope stress response is the major pathway to ensure homeostasis in the envelope compartment of the cell." [GOC:bhm, IntAct:EBI-9019066, PMID:20190044]


id: GO:1990629
name: phospholamban complex
namespace: cellular_component
def:
  "A protein complex found as a homopentamer of the phospholamban (PLN) protein in the sarcoplasmic reticulum (SR) membrane of cardiomyocytes. Cardiac PLN is a main determinant of muscle contraction and relaxation, by regulating intracellular calcium levels." [GOC:ame, IntAct:EBI-10104734, PMID:16043693]


id: GO:1990630
name: IRE1-RACK1-PP2A complex
namespace: cellular_component
def:
  "A protein complex consisting of IRE1 (Inositol-requiring enzyme-1), RACK1 (Receptor of activated protein kinase C 1, GNB2L1) and PP2A (protein phosphatase 2A). RACK1 acts as an adaptor to bridge an interaction between IRE1 and PP2A." [GOC:bf, GOC:PARL, PMID:20103773]


id: GO:1990631
name: ErbB-4 class receptor binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with the protein-tyrosine kinase receptor ErbB-4/HER4." [GOC:sl, PMID:18523588]


id: GO:1990632
name: branching involved in submandibular gland morphogenesis
namespace: biological_process
def:
  "The process in which the branching structure of the submandibular gland is generated and organized." [PMID:15063181, PMID:20890964]


id: GO:1990633
name: mutator focus
namespace: cellular_component
def:
  "A type of punctate focus localized to the perinuclear region of germline cytoplasm in C. elegans. Mutator foci are required for RNA interference (RNAi) and serve as sites of small inhibitory RNA (siRNA) amplification. As such, proteins that localize to mutator foci include RNA-directed RNA polymerases (RdRPs) and beta-nucleotidyltransferases. Mutator foci are distinct from, but adjacent to or partially overlap, P granules." [PMID:22713602, PMID:25635455]


id: GO:1990636
name: reproductive senescence
namespace: biological_process
def:
  "A natural reduction in reproductive capacity with aging, often taking the form of a switch from regular reproductive cycles to irregular and infrequent ones." [PMID:24914937, PMID:25523082]


id: GO:1990637
name: response to prolactin
namespace: biological_process
def:
  "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a prolactin stimulus. The anterior pituitary hormone prolactin has a number of roles including being essential for lactation." [PMID:7760850]


id: GO:1990638
name: response to granulocyte colony-stimulating factor
namespace: biological_process
def:
  "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a granulocyte colony-stimulating factor stimulus." [PMID:9488469]


id: GO:1990639
name: obsolete inositol-3,4,5-trisphosphate 5-phosphatase activity
namespace: molecular_function
def:
  "OBSOLETE. Catalysis of the reaction: D-myo-inositol 3,4,5-trisphosphate + H2O = myo-inositol 3,4-bisphosphate + phosphate." [PMID:11348594]


id: GO:1990640
name: inositol-2,4,5-triphosphate 5-phosphatase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 1D-myo-inositol 2,4,5-trisphosphate + H2O = 1D-myo-inositol 2,4-bisphosphate + phosphate." [PMID:15316017]


id: GO:1990641
name: response to iron ion starvation
namespace: biological_process
def:
  "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a starvation stimulus, deprivation of iron ion." [PMID:16208485]


id: GO:1990642
name: obsolete response to castration
namespace: biological_process
def:
  "OBSOLETE. Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a castration stimulus, deprivation of gonads." [PMID:11255226]


id: GO:1990643
name: cellular response to granulocyte colony-stimulating factor
namespace: biological_process
def:
  "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a granulocyte colony-stimulating factor stimulus." [PMID:9488469]


id: GO:1990644
name: microtubule site clamp
namespace: molecular_function
def:
  "The binding activity of a molecule that attaches the spindle microtubules to the kinetochore." [PMID:20723757]


id: GO:1990646
name: cellular response to prolactin
namespace: biological_process
def:
  "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a prolactin stimulus." [PMID:7760850]


id: GO:1990647
name: C/EBP complex
namespace: cellular_component
def:
  "A dimeric, sequence specific DNA-binding transcription factor complex regulating the expression of genes involved in immune and inflammatory responses. Exists at least as alpha and beta homodimeric forms. Binds to regulatory regions of several acute-phase and cytokines genes and probably plays a role in the regulation of acute-phase reaction, inflammation and hemopoiesis. The consensus recognition site is 5'-T[TG]NNGNAA[TG]-3'. Transcription factor activity is inhibited by binding of CHOP forming heterodimers with alternative transcription factor activities." [GOC:bhm, GOC:pad, GOC:PARL, IntAct:EBI-10637780, PMID:8657121]


id: GO:1990648
name: inositol-4,5,6-triphosphate 5-phosphatase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 1D-myo-inositol 4,5,6-trisphosphate + H2O = 1D-myo-inositol 4,6-bisphosphate + phosphate." [GOC:al, PMID:15316017]


id: GO:1990649
name: inositol-1,2,4,5-tetrakisphosphate 5-phosphatase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 1D-myo-inositol 1,2,4,5-tetrakisphosphate + H2O = 1D-myo-inositol 1,2,4-trisphosphate + phosphate." [GOC:al, PMID:15316017]


id: GO:1990650
name: inositol-2,4,5,6-tetrakisphosphate 5-phosphatase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 1D-myo-inositol 2,4,5,6-tetrakisphosphate + H2O = 1D-myo-inositol 2,4,6-trisphosphate + phosphate." [GOC:al, PMID:15316017]


id: GO:1990651
name: inositol-1,2,4,5,6-pentakisphosphate 5-phosphatase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 1D-myo-inositol 1,2,4,5,6-pentakisphosphate + H2O = 1D-myo-inositol 1,2,4,6-tetrakisphosphate + phosphate." [GOC:al, PMID:15316017]


id: GO:1990652
namespace: biological_process
name:
  obsolete positive regulation of pyrimidine-containing compound salvage by positive regulation of transcription from RNA polymerase II promoter

def:
  "OBSOLETE. A positive regulation of transcription from RNA polymerase II promoter that results in positive regulation of pyrimidine-containing compound salvage." [PMID:23695302]


id: GO:1990653
name: obsolete monounsaturated fatty acid biosynthetic process
namespace: biological_process
def:
  "OBSOLETE. The chemical reactions and pathways resulting in the formation of a monounsaturated fatty acid. A monounsaturated fatty acid has one double bond in the fatty acid chain with all of the remainder carbon atoms being single-bonded, as opposed to polyunsaturated fatty acids." [GOC:hjd, PMID:16443825]


id: GO:1990654
name: sebum secreting cell proliferation
namespace: biological_process
def:
  "The multiplication or reproduction of sebocytes by cell division, resulting in the expansion of their population. A sebocyte is an epithelial cell that makes up the sebaceous glands, and secrete sebum." [GOC:hjd, PMID:16901790, PMID:18474083]


id: GO:1990655
name: 4 iron, 3 sulfur cluster binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with a 4 iron, 3 sulfur (4Fe-3S) cluster, an uncommon iron-sulfur cluster with unique properties found in oxygen-tolerant Ni-Fe hydrogenases of various bacteria." [GOC:am, PMID:23267108]


id: GO:1990656
name: t-SNARE clustering
namespace: biological_process
def:
  "The clustering process in which t-SNARES are localized to distinct domains in the cell membrane. t-SNAREs are cell surface proteins which are part of secretory microdomain assemblies." [PMID:22528485]


id: GO:1990657
name: iNOS-S100A8/A9 complex
namespace: cellular_component
def:
  "A protein complex capable of stimulus-inducible nitric-oxide synthase activity. S-nitrosylates cysteine residues in target proteins, a principal mechanism of nitric oxide (NO)-mediated signal transduction. In mammals consists of NOS2, S100A8 and S100A9. S100A9 acts both as an adaptor linking NOS2 to its target and as a transnitrosylase that transfers the nitric oxide moiety from NOS2 to its target, via its own S-nitrosylated cysteine." [GOC:bhm, IntAct:EBI-10105915, IntAct:EBI-10106087, PMID:25417112]


id: GO:1990658
name: transnitrosylase complex
namespace: cellular_component
def:
  "A transferase complex which is capable of transferring nitrogenous groups from one component to another." [GOC:bhm, IntAct:EBI-10105915, IntAct:EBI-10106087, PMID:25417112]


id: GO:1990659
name: sequestering of manganese ion
namespace: biological_process
def:
  "The process of binding or confining manganese ions such that they are separated from other components of a biological system." [GOC:bhm, PMID:25417112]


id: GO:1990660
name: calprotectin complex
namespace: cellular_component
def:
  "A protein complex composed of S100A8 and S100A9 and capable of limiting Mn(2+) and Zn(2+) availability at sites of infection. Also binds Ca(2+). Expressed and released by neutrophils and epithelial cells, it exhibits broad-spectrum antimicrobial activity attributed to its metal-binding properties. Endogenous ligand of toll-like receptor 4 (TLR4) and of the receptor for advanced glycation end products (RAGE) initiating signal transduction through NF-kappa-B pathways." [GOC:bhm, IntAct:EBI-10098135, IntAct:EBI-10098681, IntAct:EBI-10098713, PMID:25417112]


id: GO:1990661
name: S100A8 complex
namespace: cellular_component
def:
  "A protein complex composed of a S100A8 dimer and capable of binding to toll-like receptor 4 (TLR4)." [GOC:bhm, IntAct:EBI-10098921, IntAct:EBI-10099454, PMID:25417112]


id: GO:1990662
name: S100A9 complex
namespace: cellular_component
def:
  "A protein complex composed of a S100A9 dimer and capable of binding to toll-like receptor 4 (TLR4) and the receptor for advanced glycation end products (RAGE) initiating signal transduction through NF-kappa-B pathways. Transports arachidonic acid between the cytosol and the NADPH oxidase complex at the plasma membrane in neutrophils as part of an inflammatory signal cascade leading to an oxidative burst. Complexes with microtubules to increase cell motility." [GOC:bhm, IntAct:EBI-10098921, IntAct:EBI-10099454, PMID:15642721]


id: GO:1990664
name: Nkx-2.5 complex
namespace: cellular_component
def:
  "A transcription factor complex formed by two or more subunits of Nkx-2.5. Nkx-2.5 is an evolutionary conserved transcription factor important for the specification and differentiation of cardiomyocytes during heart development. It is also required for spleen development. It binds DNA either as a monomer, or a homodimer, or a heterodimer complex to activate or inhibit expression of genes." [GOC:ame, IntAct:EBI-10636829, PMID:22849347]


id: GO:1990665
name: AnxA2-p11 complex
namespace: cellular_component
def:
  "A heterotetrameric protein complex comprising two Annexin A2 (AnxA2) monomers and two copies of its binding partner, S100 protein p11 (S100A10)." [GOC:bf, GOC:BHF, GOC:nc, PMID:18799458, PMID:23483454]


id: GO:1990666
name: PCSK9-LDLR complex
namespace: cellular_component
def:
  "A protein complex consisting of the serine protease PCSK9 (Proprotein convertase subtilisin/kexin-9) and a low-density lipoprotein receptor (LDLR). Interaction typically occurs through the epidermal growth factor-like repeat A (EGF-A) domain of the LDLR, and complex formation promotes degradation of the LDLR through the endosome/lysosome pathway." [GOC:BHF, GOC:nc, PMID:18250299, PMID:24440079]


id: GO:1990667
name: PCSK9-AnxA2 complex
namespace: cellular_component
def:
  "A protein complex consisting of the serine protease PCSK9 (Proprotein convertase subtilisin/kexin-9) and Annexin A2 (AnxA2)." [GOC:BHF, GOC:nc, PMID:22848640]


id: GO:1990668
name: vesicle fusion with endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane
namespace: biological_process
def:
  "The joining of the lipid bilayer membrane around a vesicle to the lipid bilayer membrane of the ERGIC. This can involve anterograde or retrograde transport vesicles." [GOC:bhm, PMID:16038056, PMID:24119662]


id: GO:1990669
namespace: biological_process
name:
  endoplasmic reticulum-Golgi intermediate compartment (ERGIC) derived vesicle fusion with endoplasmic reticulum membrane

def:
  "The joining of the lipid bilayer membrane around an ERGIC-derived vesicle to the lipid bilayer membrane of the ER. Such vesicles include COPI-coated transport vesicles involved in retrograde transport." [GOC:bhm, PMID:16038056, PMID:24119662]


id: GO:1990670
name: vesicle fusion with Golgi cis cisterna membrane
namespace: biological_process
def:
  "The joining of the lipid bilayer membrane around a vesicle to the lipid bilayer membrane around the Golgi cis cisterna. This can involve anterograde or retrograde transport vesicles." [GOC:bhm, PMID:16038056, PMID:24119662]


id: GO:1990671
name: vesicle fusion with Golgi medial cisterna membrane
namespace: biological_process
def:
  "The joining of the lipid bilayer membrane around a vesicle to the lipid bilayer membrane around the Golgi medial cisterna. This can involve anterograde or retrograde transport vesicles." [GOC:bhm, PMID:16038056, PMID:24119662]


id: GO:1990672
name: medial-Golgi-derived vesicle fusion with Golgi trans cisterna membrane
namespace: biological_process
def:
  "The joining of the lipid bilayer membrane around a medial-Golgi-derived vesicle to the lipid bilayer membrane around the Golgi trans cisterna. Vesicles are involved in anterograde transport." [GOC:bhm, PMID:16038056, PMID:24119662]


id: GO:1990673
name: intrinsic component of endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane
namespace: cellular_component
def:
  "The component of the ERGIC membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane." [GOC:bhm, PMID:16038056, PMID:24119662]


id: GO:1990674
name: Golgi cis cisterna membrane
namespace: cellular_component
def:
  "The lipid bilayer surrounding any of the thin, flattened compartments that form the cis portion of the Golgi complex." [GOC:bhm, PMID:16038056, PMID:24119662]


id: GO:1990675
name: Golgi medial cisterna membrane
namespace: cellular_component
def:
  "The lipid bilayer surrounding any of the thin, flattened compartments that form the medial portion of the Golgi complex." [GOC:bhm, PMID:16038056, PMID:24119662]


id: GO:1990676
name: Golgi trans cisterna membrane
namespace: cellular_component
def:
  "The lipid bilayer surrounding any of the thin, flattened compartments that form the trans portion of the Golgi complex." [GOC:bhm, PMID:16038056, PMID:24119662]


id: GO:1990677
name: mitochondrial inner membrane assembly complex
namespace: cellular_component
def:
  "A protein complex that promotes the biogenesis of mitochondrial F1Fo-ATP synthase by facilitating assembly of the peripheral stalk. Loss of INAC function causes dissociation of the F1-domain from the membrane-integral Fo-portion." [GOC:bhm, PMID:24942160]


id: GO:1990678
name: histone H4-K16 deacetylation
namespace: biological_process
def:
  "The modification of histone H4 by the removal of an acetyl group from lysine at position 16 of the histone." [PMID:17446861]


id: GO:1990679
name: histone H4-K12 deacetylation
namespace: biological_process
def:
  "The modification of histone H4 by the removal of an acetyl group from lysine at position 12 of the histone." [PMID:17446861]


id: GO:1990680
name: response to melanocyte-stimulating hormone
namespace: biological_process
def:
  "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a melanocyte-stimulating hormone stimulus. The binding of any one of three melanocyte-stimulating hormones causes dispersal of melanosomes in melanophores of poikilothermic vertebrates." [PMID:17036007]


id: GO:1990682
name: CSF1-CSF1R complex
namespace: cellular_component
def:
  "A protein complex consisting of a macrophage colony-stimulating factor (CSF1, also called M-CSF) dimer bound to a dimerized receptor (CSF1R, also called FMS). Receptor dimerization requires the presence of the ligand." [GOC:bf, GOC:BHF, GOC:nc, PMID:19017797]


id: GO:1990683
name: DNA double-strand break attachment to nuclear envelope
namespace: biological_process
def:
  "A process in which the DNA double-strand breaks are attached to the inner surface of the nuclear envelope proximal to the spindle pole body, or iMTOCs." [PMID:24943839]


id: GO:1990684
name: protein-lipid-RNA complex
namespace: cellular_component
def:
  "A macromolecular complex containing separate protein, lipid and RNA molecules. Separate in this context means not covalently bound to each other." [GOC:vesicles, PMID:21423178, PMID:22028337, PMID:23559634]


id: GO:1990685
name: HDL-containing protein-lipid-RNA complex
namespace: cellular_component
def:
  "A protein-lipid-RNA complex containing separate high-density lipoprotein (HDL), lipid and RNA molecules. Separate in this context means not covalently bound to each other." [GOC:vesicles, PMID:21423178, PMID:23559634]


id: GO:1990686
name: LDL-containing protein-lipid-RNA complex
namespace: cellular_component
def:
  "A protein-lipid-RNA complex containing separate low-density lipoprotein (LDL), lipid and RNA molecules. Separate in this context means not covalently bound to each other." [GOC:vesicles, PMID:23559634]


id: GO:1990687
namespace: biological_process
name:
  endoplasmic reticulum-derived vesicle fusion with endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane

def:
  "The joining of the lipid bilayer membrane around an endoplasmic reticulum-derived vesicle to the lipid bilayer membrane of the ERGIC. Such vesicles include COPII-coated transport vesicles involved in anterograde transport." [GOC:bhm, PMID:16038056, PMID:24119662]


id: GO:1990688
name: Golgi vesicle fusion with endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane
namespace: biological_process
def:
  "The joining of the lipid bilayer membrane around a Golgi vesicle to the lipid bilayer membrane of the ERGIC. Such vesicles include COPI-coated transport vesicles involved in retrograde transport." [GOC:bhm, PMID:16038056, PMID:24119662]


id: GO:1990689
namespace: biological_process
name:
  endoplasmic reticulum-Golgi intermediate compartment (ERGIC) derived vesicle fusion with Golgi cis cisterna membrane

def:
  "The joining of the lipid bilayer membrane around an ERGIC-derived vesicle to the lipid bilayer membrane around the Golgi cis cisterna. Such vesicles include COPII-coated transport vesicles involved in anterograde transport." [GOC:bhm, PMID:16038056, PMID:24119662]


id: GO:1990690
name: Golgi medial cisterna-derived vesicle fusion with Golgi cis cisterna membrane
namespace: biological_process
def:
  "The joining of the lipid bilayer membrane around a Golgi medial cisterna-derived vesicle to the lipid bilayer membrane around the Golgi cis cisterna. Such vesicles include COPI-coated transport vesicles involved in retrograde transport." [GOC:bhm, PMID:16038056, PMID:24119662]


id: GO:1990691
name: cis-Golgi-derived vesicle fusion with Golgi medial cisterna membrane
namespace: biological_process
def:
  "The joining of the lipid bilayer membrane around a cis-Golgi-derived vesicle to the lipid bilayer membrane around the medial-Golgi cisterna. Vesicles are involved in anterograde transport." [GOC:bhm, PMID:16038056, PMID:24119662]


id: GO:1990692
name: trans-Golgi-derived vesicle fusion with Golgi medial cisterna membrane
namespace: biological_process
def:
  "The joining of the lipid bilayer membrane around a trans-Golgi-derived vesicle to the lipid bilayer membrane around the medial-Golgi cisterna. Such vesicles include COPI-coated transport vesicles involved in retrograde transport." [GOC:bhm, PMID:16038056, PMID:24119662]


id: GO:1990693
name: intrinsic component of Golgi cis cisterna membrane
namespace: cellular_component
def:
  "The component of the Golgi cis cisterna membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane." [GOC:bhm, PMID:16038056, PMID:24119662]


id: GO:1990694
name: intrinsic component of Golgi medial cisterna membrane
namespace: cellular_component
def:
  "The component of the Golgi medial cisterna membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane." [GOC:bhm, PMID:16038056, PMID:24119662]


id: GO:1990695
name: intrinsic component of Golgi trans cisterna membrane
namespace: cellular_component
def:
  "The component of the Golgi trans cisterna membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane." [GOC:bhm, PMID:16038056, PMID:24119662]


id: GO:1990696
name: USH2 complex
namespace: cellular_component
def:
  "A protein complex composed of four proteins, loss of which results in Usher Syndrome type 2 (USH2 syndrome), a leading genetic cause of combined hearing and vision loss. This complex is conserved in many species; in mice, it is composed of USH2A, GPR98 (aka ADGRV1), WHRN, and PDZD7." [GOC:krc, PMID:25406310]


id: GO:1990697
name: protein depalmitoleylation
namespace: biological_process
def:
  "The removal of palmitoleyl group, a 16-carbon monounsaturated fatty acid (C16:1), from a lipoprotein." [PMID:25731175]


id: GO:1990698
name: palmitoleoyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the transfer of a palmitoleyl group, a 16-carbon monounsaturated fatty acid (C16:1), to an acceptor molecule." [PMID:17141155, PMID:25731175]


id: GO:1990699
name: palmitoleyl hydrolase activity
namespace: molecular_function
def:
  "Catalysis of a hydrolase reaction that removes a palmitoleyl moiety, a 16-carbon monounsaturated fatty acid (C16:1), from some substrate." [PMID:25731175]


id: GO:1990700
name: nucleolar chromatin organization
namespace: biological_process
def:
  "Any process that results in the specification, formation or maintenance of the physical structure of nucleolar chromatin." [PMID:18362178]


id: GO:1990701
name: integral component of endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane
namespace: cellular_component
def:
  "The component of the ERGIC membrane consisting of the gene products having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:bhm, PMID:16038056, PMID:24119662]


id: GO:1990702
name: integral component of Golgi cis cisterna membrane
namespace: cellular_component
def:
  "The component of the Golgi cis membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:bhm, PMID:16038056, PMID:24119662]


id: GO:1990703
name: integral component of Golgi medial cisterna membrane
namespace: cellular_component
def:
  "The component of the Golgi medial membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:bhm, PMID:16038056, PMID:24119662]


id: GO:1990704
name: integral component of Golgi trans cisterna membrane
namespace: cellular_component
def:
  "The component of the Golgi trans membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:bhm, PMID:16038056, PMID:24119662]


id: GO:1990705
name: cholangiocyte proliferation
namespace: biological_process
def:
  "The multiplication or reproduction of cholangiocytes, resulting in the expansion of the cholangiocyte population. A cholangiocyte is an epithelial cell that is part of the bile duct. Cholangiocytes contribute to bile secretion via net release of bicarbonate and water." [PMID:24434010]


id: GO:1990706
name: MAD1 complex
namespace: cellular_component
def:
  "A protein complex involved in the assembly of the mitotic checkpoint complex that in turn inhibits the anaphase promoting complex/cyclosome (APC/C)." [GOC:bhm, IntAct:EBI-10691160, intAct:EBI-10691224, PMID:22493223, PMID:22898774]


id: GO:1990707
name: nuclear subtelomeric heterochromatin
namespace: cellular_component
def:
  "Heterochromatic regions of the chromosome found at the subtelomeric regions of a chromosome in the nucleus." [PMID:7660126]


id: GO:1990708
name: conditioned place preference
namespace: biological_process
def:
  "The associative learning process by which an animal learns and remembers an association between a neutral, unchanging environment and a putatively rewarding, internal state produced by a xenobiotic or drug." [PMID:21549821]


id: GO:1990709
name: presynaptic active zone organization
namespace: biological_process
def:
  "A process that results in the assembly, arrangement of constituent parts, or disassembly of a presynaptic active zone." [GOC:pr, PMID:16865347, PMID:17068967]


id: GO:1990710
name: MutS complex
namespace: cellular_component
def:
  "A homodimeric mismatch repair complex involved in binding to and correcting insertion/deletion mutations." [GOC:bhm, IntAct:EBI-10705937, PMID:21666597]


id: GO:1990711
name: Beta-catenin-ICAT complex
namespace: cellular_component
def:
  "Transcription factor complex that inhibits binding of Tcf to beta-catenin while preserving interaction of catenin with cadherin thus inhibiting transcription mediated by beta-catenin-Tcf complex." [GOC:bhm, IntAct:EBI-10691252, IntAct:EBI-10705284, PMID:12408824]


id: GO:1990712
name: HFE-transferrin receptor complex
namespace: cellular_component
def:
  "A protein complex containing at least HFE and a transferrin receptor (either TFR1/TFRC or TFR2), proposed to play a role in the sensing of transferrin-bound Fe (Fe2-Tf) on the plasma membrane to regulate hepcidin transcription." [GOC:BHF, GOC:kom, PMID:25147378]


id: GO:1990713
name: survivin complex
namespace: cellular_component
def:
  "A protein complex that negatively regulates apoptotic processes. In human, this anti-apoptotic complex is a homodimer of BIRC5 (survivin) and provides one survivin molecule to the chromosomal passenger complex (CPC)." [GOC:bhm, IntAct:EBI-10714791, IntAct:EBI-10727115, PMID:10949038]


id: GO:1990714
name: hydroxyproline O-galactosyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the transfer of galactose from UDP-galactose to hydroxyproline residues present in the peptide backbone." [PMID:25600942]


id: GO:1990715
name: mRNA CDS binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with the coding sequence (CDS) of an mRNA molecule." [GOC:kmv, PMID:25805859, SO:0000316]


id: GO:1990716
name: axonemal central apparatus
namespace: cellular_component
def:
  "Part of the 9+2 axoneme, that occurs in most motile cilia, consisting of the pair of two single central microtubules and their associated structures which include the central pair projections, the central pair bridges linking the two tubules, and the central pair caps which are attached to the distal or plus ends of the microtubules." [GOC:cilia, PMID:21586547, PMID:9295136]


id: GO:1990717
name: axonemal central bridge
namespace: cellular_component
def:
  "Part of the 9+2 axoneme, that occurs in most motile cilia, consisting of the two bridges which connect the central pair of single microtubules." [GOC:cilia, PMID:21586547, PMID:9295136]


id: GO:1990718
name: axonemal central pair projection
namespace: cellular_component
def:
  "Part of the 9+2 axoneme, that occurs in most motile cilia, consisting of the projections off of the central pair of single microtubules." [GOC:cilia, PMID:21586547, PMID:9295136]


id: GO:1990719
name: C1 axonemal microtubule
namespace: cellular_component
def:
  "One of two microtubules present in the axonemal central pair. It is distinguishable from the C2 axonemal microtubule (also called C2 tubule) by the presence of differing protein components of the projections." [GOC:cilia, PMID:21586547, PMID:9295136]


id: GO:1990720
name: C2 axonemal microtubule
namespace: cellular_component
def:
  "One of two microtubules present in the axonemal central pair. It is distinguishable from the C1 axonemal microtubule (also called C1 tubule) by the presence of differing protein components of the projections." [GOC:cilia, PMID:21586547, PMID:9295136]


id: GO:1990721
name: obsolete prostatic acid phosphatase complex
namespace: cellular_component
def:
  "OBSOLETE. A protein complex that is capable of dephosphorylation of alky, aryl and acyl orthophosphate monoesters and phosphorylated proteins. Optimal activity in acidic environment (pH 4-6). In mammals it consists of a homodimer of ACPP." [GOC:bhm, IntAct:EBI-10758257, IntAct:EBI-10758292, PMID:12525165]


id: GO:1990722
name: DAPK1-calmodulin complex
namespace: cellular_component
def:
  "A serine/threonine protein kinase complex involved in cell survival, apoptosis and autophagic cell death pathways. DAPK1 is activated by the dephosphorylation of a n-terminal serine and calcium-calmodulin binding." [GOC:bhm, IntAct:EBI-10758257, IntAct:EBI-10758292, PMID:20103772]


id: GO:1990724
name: galectin complex
namespace: cellular_component
def:
  "A homodimeric protein complex that is capable of binding a range of carbohydrates and is involved in anti-inflammatory and pro-apoptotic processes." [GOC:bhm, IntAct:EBI-10705755, IntAct:EBI-10705946, IntAct:EBI-10705984, IntAct:EBI-10706026, PMID:15476813, PMID:18777589, PMID:8262940]


id: GO:1990725
name: cord factor receptor activity
namespace: molecular_function
def:
  "Combining with a cord factor, an M. tuberculosis cell wall glycolipid, and transmitting a signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:hjd, PMID:23602766]


id: GO:1990726
name: Lsm1-7-Pat1 complex
namespace: cellular_component
def:
  "A conserved protein complex that plays an important role in coupling deadenylation and decapping in the 5'-to-3' mRNA decay pathway. An example is found in S. cerevisiae." [GOC:jd, PMID:24139796]


id: GO:1990727
name: tubulin folding cofactor complex
namespace: cellular_component
def:
  "A multimeric protein complex involved in tubulin alpha-beta-subunit folding assembly consisting of beta-tubulin-TFC-D, alpha-tubulin-TFC-E and TFC-C, through which tubulin subunit association and dimer release occur." [GOC:vw, PMID:12445400]


id: GO:1990728
name: mitotic spindle assembly checkpoint MAD1-MAD2 complex
namespace: cellular_component
def:
  "A protein complex involved in the assembly of the mitotic checkpoint complex that in turn inhibits the anaphase promoting complex/cyclosome (APC/C). The MAD1 dimer recruits the open form of MAD2 (O-MAD2) turning it into the closed form (C-MAD2) upon binding. C-MAD2 inhibits CDC20, a member of the APC/C, upon release from the MAD1-MAD2 complex." [GOC:bhm, IntAct:EBI-10691260, IntAct:EBI-10705307, PMID:12006501, PMID:22898774]


id: GO:1990729
name: primary miRNA modification
namespace: biological_process
def:
  "The covalent alteration of one or more nucleotides within a primary miRNA molecule to produce a primary miRNA molecule with a sequence that differs from that coded genetically." [PMID:25799998]


id: GO:1990730
name: VCP-NSFL1C complex
namespace: cellular_component
def:
  "A protein complex between the ATPase VCP (p97) and its cofactor p47 (NSFL1C). In human, the protein complex consists of one homotrimer of NSFL1C/p47 per homohexamer of VCP/p97." [GOC:bf, GOC:PARL, PMID:9214505]


id: GO:1990731
name: UV-damage excision repair, DNA incision
namespace: biological_process
def:
  "A process that results in the endonucleolytic cleavage of the damaged strand of DNA immediately 5' of a UV-induced damage site, and is the first part of a DNA repair process that acts on both cyclobutane pyrimidine dimers (CPDs) and pyrimidine-pyrimidone 6-4 photoproducts (6-4PPs)." [PMID:10704216]


id: GO:1990732
name: pyrenoid
namespace: cellular_component
def:
  "A non-membrane-bounded organelle found within the chloroplasts of algae and hornworts; responsible for carbon dioxide fixation." [GOC:cjm, http://en.wikipedia.org/wiki/Pyrenoid, PMID:23345319]


id: GO:1990733
name: titin-telethonin complex
namespace: cellular_component
def:
  "A protein complex formed between the N-terminus of the giant sarcomeric filament protein titin and the Z-disk ligand, telethonin. The complex is part of the Z-disk of the skeletal and cardiac sarcomere. Telethonin binding to titin might be essential for the initial assembly, stabilization and functional integrity of the titin filament, and hence important for muscle contraction relaxation in mature myofibrils." [GOC:ame, IntAct:EBI-10711453, PMID:16407954]


id: GO:1990734
name: astral microtubule anchoring at mitotic spindle pole body
namespace: biological_process
def:
  "Any process in which an astral microtubule is maintained in a specific location in a cell by attachment to a mitotic spindle pole body. Microtubules attach to spindle pole bodies at the minus end." [PMID:15004232]


id: GO:1990735
name: gamma-tubulin complex localization to mitotic spindle pole body
namespace: biological_process
def:
  "Any process in which a gamma-tubulin complex is transported to, or maintained in, a specific location at a mitotic spindle pole body." [GOC:dos, GOC:mah, PMID:11080156]


id: GO:1990736
name: regulation of vascular smooth muscle cell membrane depolarization
namespace: biological_process
def:
  "Any process that modulates the establishment or extent of a membrane potential in the depolarizing direction away from the resting potential in a vascular smooth muscle cell." [PMID:20826763]


id: GO:1990737
name: response to manganese-induced endoplasmic reticulum stress
namespace: biological_process
def:
  "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of endoplasmic reticulum stress caused by a manganese stimulus." [GOC:bf, GOC:PARL, PMID:23934647]


id: GO:1990738
name: pseudouridine 5'-phosphatase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: pseudouridine 5'-phosphate + H2O = pseudouridine + phosphate." [EC:3.1.3.96, PMID:20722631]


id: GO:1990739
name: granulosa cell proliferation
namespace: biological_process
def:
  "The multiplication or reproduction of granulosa cells, resulting in the expansion of the granulosa cells population. A granulosa cell is a supporting cell for the developing female gamete in the ovary of mammals. They develop from the coelomic epithelial cells of the gonadal ridge." [PMID:22383759]


id: GO:1990740
name: obsolete non-selective anion channel activity
namespace: molecular_function
def:
  "OBSOLETE. Enables the non-selective, energy-independent passage of anions across a lipid bilayer down a concentration gradient." [GOC:pr, ISBN:0878937420, Wikipedia:Ion_channel#Classification_by_type_of_ions]


id: GO:1990741
name: obsolete non-selective cation channel activity
namespace: molecular_function
def:
  "OBSOLETE. Enables the non-selective, energy-independent passage of cations across a lipid bilayer down a concentration gradient." [GOC:pr, ISBN:0878937420, Wikipedia:Ion_channel#Classification_by_type_of_ions]


id: GO:1990742
name: microvesicle
namespace: cellular_component
def:
  "An extracellular vesicle released from the plasma membrane and ranging in size from about 100 nm to 1000 nm." [GOC:vesicles, PMID:22418571, PMID:24009894, Wikipedia:Microvesicles]


id: GO:1990743
name: protein sialylation
namespace: biological_process
def:
  "A protein modification process that results in the addition of a sialic acid unit to the end of an oligosaccharide chain in a glycoprotein." [PMID:21930713]


id: GO:1990744
name: primary miRNA methylation
namespace: biological_process
def:
  "The posttranscriptional addition of methyl groups to specific residues in an primary miRNA molecule." [PMID:25799998]


id: GO:1990746
name: HCN4 channel complex
namespace: cellular_component
def:
  "HCN4 tetramer is a hyperpolarization-activated ion channel with selectivity for potassium over sodium ions. HCN4 is the dominant form of HCN expressed in the heart, together with HCN2. HCN4 expression is particularly high in the sinoatrial node, where impulses initiate and propagate throughout the heart. There is pharmacologic and genetic evidence that the HNC4 channel complex plays a role in cardiac pacemaking and automaticity, by contributing to the native pacemaker current of the heart (If). Mutations in the C-terminus containing the C-linker and CNBD domain, which affect the expression or function of the HCN4 channel are known to cause arrhythmia or bradycardia." [GOC:ame, IntAct:EBI-10814846, PMID:20829353]


id: GO:1990748
name: cellular detoxification
namespace: biological_process
def:
  "Any process carried out at the cellular level that reduces or removes the toxicity of a toxic substance. These may include transport of the toxic substance away from sensitive areas and to compartments or complexes whose purpose is sequestration of the toxic substance." [GOC:vw]


id: GO:1990750
name: obsolete axon shaft
namespace: cellular_component
def:
  "OBSOLETE. Main portion of an axon, excluding terminal, spines, or dendrites." [PMID:11264310, PMID:24312009]


id: GO:1990751
name: Schwann cell chemotaxis
namespace: biological_process
def:
  "The directed movement of a Schwann cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis)." [PMID:16203995]


id: GO:1990752
name: microtubule end
namespace: cellular_component
def:
  "Any end of a microtubule. Microtubule ends differ in that the so-called microtubule plus-end is the one that preferentially grows by polymerization, with respect to the minus-end." [GOC:pr]


id: GO:1990753
name: equatorial cell cortex
namespace: cellular_component
def:
  "The region of the cell cortex in a mitotically dividing cell that flanks the central spindle and corresponds to the site of actomyosin ring formation that results in cleavage furrow formation and ingression." [PMID:16352658, PMID:22552143, PMID:23750214, PMID:25898168]


id: GO:1990755
name: mitotic spindle microtubule depolymerization
namespace: biological_process
def:
  "The removal of tubulin heterodimers from one or both ends of a microtubule that is part of the mitotic spindle." [PMID:25253718]


id: GO:1990756
name: protein binding, bridging involved in substrate recognition for ubiquitination
namespace: molecular_function
def:
  "The binding activity of a molecule that brings together a ubiquitin ligase and its substrate. Usually mediated by F-box BTB/POZ domain proteins." [PMID:24658274]


id: GO:1990758
name: mitotic sister chromatid biorientation
namespace: biological_process
def:
  "The mitotic cell cycle process in which sister chromatids establish stable, end-on attachments to the plus ends of microtubules emanating from opposite spindle poles, oriented such that separation can proceed. This is the final step of metaphase plate congression." [PMID:15309047, PMID:26258632, PMID:26705896]


id: GO:1990759
name: HCN2 channel complex
namespace: cellular_component
def:
  "HCN2 is a member of the hyperpolarization-activated ion channel family, which shows selectivity for potassium over sodium ions. Channel gating is facilitated by cAMP binding to the cyclic nucleotide binding domain. HCN2 is the dominant form of HCN expressed in the heart, together with HCN4 (O70507). HCN2 shows significant expression in various regions of the heart, especially the ventricles. There is pharmacological and genetic evidence that HCN channels play a role in cardiac pacemaking and automaticity, by contributing to the native pacemaker current of the heart (If)." [GOC:ame, IntAct:EBI-10825931, PMID:12968185]


id: GO:1990760
name: osmolarity-sensing cation channel activity
namespace: molecular_function
def:
  "Enables the transmembrane transfer of a cation by a channel that opens when a change in the osmolarity occurs in the extracellular space of the cell in which the cation channel resides." [PMID:18279313]


id: GO:1990761
name: growth cone lamellipodium
namespace: cellular_component
def:
  "A thin sheetlike process extended by the leading edge of an axonal or dendritic growth cone; contains a dense meshwork of actin filaments." [GOC:dos, PMID:25598228]


id: GO:1990762
name: cytoplasmic alanyl-tRNA aminoacylation
namespace: biological_process
def:
  "The process of coupling alanine to alanyl-tRNA, catalyzed by alanyl-tRNA synthetase involved in cytoplasmic translation." [GOC:vw]


id: GO:1990763
name: arrestin family protein binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with any member of the arrestin family, proteins involved in agonist-mediated desensitization of G-protein-coupled receptors." [PMID:23911909]


id: GO:1990764
name: myofibroblast contraction
namespace: biological_process
def:
  "The actin filament-based process in which cytoplasmic actin filaments slide past one another resulting in contraction of a myofibroblast." [PMID:19239477]


id: GO:1990765
name: colon smooth muscle contraction
namespace: biological_process
def:
  "A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry of the large intestine, exclusive of the rectum. The colon is that part of the large intestine that connects the small intestine to the rectum." [PMID:24170253]


id: GO:1990767
name: prostaglandin receptor internalization
namespace: biological_process
def:
  "The process that results in the uptake of a prostaglandin receptor into an endocytic vesicle." [PMID:15937517]


id: GO:1990768
name: gastric mucosal blood circulation
namespace: biological_process
def:
  "The flow of blood through the gastric mucosa of an animal, enabling the transport of nutrients and the removal of waste products." [PMID:10807413]


id: GO:1990770
name: small intestine smooth muscle contraction
namespace: biological_process
def:
  "A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry in the intestine between the stomach and the large intestine." [PMID:11991626]


id: GO:1990772
name: substance P secretion
namespace: biological_process
def:
  "The regulated release of substance P, a peptide hormone that is involved in neurotransmission, inflammation, and antimicrobial activity." [PMID:11278900]


id: GO:1990773
name: matrix metallopeptidase secretion
namespace: biological_process
def:
  "The regulated release of matrix metallopeptidases, a family of zinc-dependent endopeptidases that can degrade extracellular matrix proteins and process other types of proteins." [PMID:8679543]


id: GO:1990774
name: tumor necrosis factor secretion
namespace: biological_process
def:
  "The regulated release of tumor necrosis factor from a cell. Tumor necrosis factor is an inflammatory cytokine produced by macrophages/monocytes during acute inflammation and which is responsible for a diverse range of signaling events within cells, leading to necrosis or apoptosis." [PMID:15560120]


id: GO:1990775
name: endothelin secretion
namespace: biological_process
def:
  "The regulated release of endothelin from a cell. Endothelins are endothelium-derived vasoactive peptides involved in a variety of biological functions." [PMID:15560120]


id: GO:1990776
name: response to angiotensin
namespace: biological_process
def:
  "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an angiotensin stimulus. Angiotensin is any of three physiologically active peptides (angiotensin II, III, or IV) processed from angiotensinogen." [PMID:22982863]


id: GO:1990777
name: lipoprotein particle
namespace: cellular_component
def:
  "A spherical particle containing non-covalently associated proteins and lipids. Examples are plasma lipoprotein particles which transport lipids in the blood or lymph." [GOC:vesicles]


id: GO:1990778
name: protein localization to cell periphery
namespace: biological_process
def:
  "A process in which a protein is transported to, or maintained in, the cell periphery." [PMID:18216290]


id: GO:1990779
name: glycoprotein Ib-IX-V complex
namespace: cellular_component
def:
  "A transmembrane signalling receptor complex found exclusively on platelets. Involved in haemostasis and thrombosis where it aids blood coagulation." [GOC:bhm, IntAct:EBI-10727454, IntAct:EBI-10728062, PMID:1730602, PMID:23336709, PMID:25297919]


id: GO:1990780
name: cytoplasmic side of dendritic spine plasma membrane
namespace: cellular_component
def:
  "The leaflet of the plasma membrane that faces the cytoplasm and any proteins embedded or anchored in it or attached to its surface surrounding a dendritic spine." [PMID:9275233]


id: GO:1990781
name: response to immobilization stress combined with electrical stimulus
namespace: biological_process
def:
  "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electrical stimulus given while being held immobile." [PMID:17008368]


id: GO:1990784
name: response to dsDNA
namespace: biological_process
def:
  "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a double-stranded DNA stimulus." [PMID:10051633]


id: GO:1990785
name: response to water-immersion restraint stress
namespace: biological_process
def:
  "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of water immersion while being held immobile." [PMID:10882227]


id: GO:1990786
name: cellular response to dsDNA
namespace: biological_process
def:
  "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a double-stranded DNA stimulus." [PMID:10051633]


id: GO:1990787
name: negative regulation of hh target transcription factor activity
namespace: biological_process
def:
  "Any process that decreases the activity of a transcription factor that activates transcription of Hedgehog-target genes in response to Smoothened signaling. In Drosophila, Cubitus interruptus (Ci) is the only identified transcription factor so far in the Hedgehog signaling pathway. In vertebrates members of the Gli protein family are activated by Hedgehog signaling." [GOC:bhm, IntAct:EBI-10170144, PMID:24311597]


id: GO:1990788
name: GLI-SUFU complex
namespace: cellular_component
def:
  "A protein repressing GLI's transcription factor activity when SMO signalling is inactive. Upon ligand binding to the upstream receptor PTC (Patched) GLI dissociates from SUFU and activates transcription of hedgehog-target genes. In mammals it consists of SUFU and one of the GLI family proteins." [GOC:bhm, IntAct:EBI-10170144, IntAct:EBI-10828915, IntAct:EBI-10828948, IntAct:EBI-10828976, IntAct:EBI-10828997, IntAct:EBI-10829035, PMID:24311597]


id: GO:1990789
name: thyroid gland epithelial cell proliferation
namespace: biological_process
def:
  "The multiplication or reproduction of thyroid gland epithelial cells, resulting in the expansion of the thyroid gland epithelial cell population." [PMID:17646383]


id: GO:1990790
name: response to glial cell derived neurotrophic factor
namespace: biological_process
def:
  "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glial cell derived neurotrophic factor stimulus." [PMID:20877310]


id: GO:1990791
name: dorsal root ganglion development
namespace: biological_process
def:
  "The process whose specific outcome is the progression of a dorsal root ganglion over time, from its formation to the mature structure." [PMID:18583150]


id: GO:1990792
name: cellular response to glial cell derived neurotrophic factor
namespace: biological_process
def:
  "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glial cell derived neurotrophic factor stimulus." [PMID:20877310]


id: GO:1990793
name: substance P secretion, neurotransmission
namespace: biological_process
def:
  "The controlled release of substance P by a cell, in which the substance P acts as a neurotransmitter." [PMID:15292051]


id: GO:1990794
name: basolateral part of cell
namespace: cellular_component
def:
  "The region of a cell situated by the cell sides which interface adjacent cells and near the base. Often used in reference to animal polarized epithelial cells." [PMID:18495799]


id: GO:1990795
name: rod bipolar cell terminal bouton
namespace: cellular_component
def:
  "A specialized region of the axon terminus portion of a rod bipolar axon. A rod bipolar cell is a neuron found in the retina and having connections with rod photoreceptor cells and neurons in the inner plexiform layer." [PMID:19883736]


id: GO:1990796
name: photoreceptor cell terminal bouton
namespace: cellular_component
def:
  "A specialized region of the axon terminus portion of a photoreceptor cell axon. A photoreceptor cell is a neuron specialized to detect and transduce light." [PMID:19883736]


id: GO:1990797
name: obsolete cholecystokinin secretion
namespace: biological_process
def:
  "OBSOLETE. The controlled release of cholecystokinin from a cell. Cholecystokinin is a peptide hormone that participates in pancreatic enzyme release in the gut and is also found in the brain." [PMID:2755938]


id: GO:1990799
name: mitochondrial tRNA wobble position uridine thiolation
namespace: biological_process
def:
  "The process in which a uridine residue at position 34 in the anticodon of a mitochondrial tRNA is post-transcriptionally thiolated at the C2 position. This process involves transfer of a sulfur from cysteine to position C2 by several steps." [PMID:15509579]


id: GO:1990801
name: protein phosphorylation involved in mitotic spindle assembly
namespace: biological_process
def:
  "Any protein phosphorylation that is involved in mitotic spindle assembly." [GO_REF:0000060, GOC:rb, GOC:TermGenie, PMID:21558801]


id: GO:1990802
name: protein phosphorylation involved in DNA double-strand break processing
namespace: biological_process
def:
  "Any protein phosphorylation that is required for DNA double-strand break processing." [GO_REF:0000060, GOC:rb, GOC:TermGenie, PMID:21841787]


id: GO:1990803
name: protein phosphorylation involved in protein localization to spindle microtubule
namespace: biological_process
def:
  "Any protein phosphorylation process involved in localizing a protein to the spindle microtubule." [GO_REF:0000060, GOC:rb, GOC:TermGenie, PMID:22521784]


id: GO:1990804
name: protein phosphorylation involved in double-strand break repair via nonhomologous end joining
namespace: biological_process
def:
  "Any protein phosphorylation process that is required for double-strand break repair via nonhomologous end joining." [GO_REF:0000060, GOC:rb, GOC:TermGenie, PMID:22563681]


id: GO:1990805
name: central cylinder
namespace: cellular_component
def:
  "A scaffolding structure present within the inner region of the ciliary transition zone. The central cylinder lies between the outer doublet and inner singlet microtubules." [GOC:kmv, PMID:2428682, PMID:26124290]


id: GO:1990806
name: obsolete ligand-gated ion channel signaling pathway
namespace: biological_process
def:
  "OBSOLETE. A series of molecular signals initiated by activation of a ligand-gated ion channel on the surface of a cell. The pathway begins with binding of an extracellular ligand to a ligand-gated ion channel and ends with a molecular function that directly regulates a downstream cellular process, e.g. transcription." [GOC:bhm, PMID:25869137]


id: GO:1990807
name: obsolete protein N-acetyltransferase activity
namespace: molecular_function
def:
  "OBSOLETE. Catalysis of the transfer of an acetyl group to a nitrogen atom on the amino acid of a protein." [GOC:dph]


id: GO:1990808
name: F-bar domain binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with an F-BAR domain of a protein, a domain of about 60 residues that occurs in a wide range of cytoskeletal proteins." [PMID:20603077]


id: GO:1990809
name: endoplasmic reticulum tubular network membrane organization
namespace: biological_process
def:
  "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the endoplasmic reticulum (ER) tubular network membrane." [PMID:20434336]


id: GO:1990810
name: microtubule anchoring at mitotic spindle pole body
namespace: biological_process
def:
  "Any process in which a microtubule is maintained in a specific location in a cell by attachment to a mitotic spindle pole body. Microtubules attach to spindle pole bodies at the minus end." [PMID:17486116]


id: GO:1990811
name: Msd1-Wdr8-Pkl1 complex
namespace: cellular_component
def:
  "A protein ternary complex that anchors microtubule minus ends to mitotic spindle pole bodies. The founding complex contains a microtubule anchoring protein (Msd1 in fission yeast), A WD-repeat Wdr8 family protein and and a minus end-directed kinesin." [PMID:25987607]


id: GO:1990812
name: growth cone filopodium
namespace: cellular_component
def:
  "A thin, stiff protrusion extended by the leading edge of an axonal or dendritic growth cone." [PMID:25598228]


id: GO:1990813
name: meiotic centromeric cohesion protection
namespace: biological_process
def:
  "The process in which the association between sister chromatids of a replicated chromosome centromeric region is maintained during homologous chromosome segregation after cohesin is cleaved by separase along the arm regions." [PMID:14730319, PMID:25533956]


id: GO:1990814
name: DNA/DNA annealing activity
namespace: molecular_function
def:
  "A nucleic acid binding activity that brings together complementary sequences of ssDNA so that they pair by hydrogen bonds to form a double-stranded DNA." [PMID:25520186]


id: GO:1990815
name: obsolete regulation of protein localization to cell division site after cytokinesis
namespace: biological_process
def:
  "OBSOLETE. Any process that modulates the frequency, rate or extent of protein localization to cell division site involved in cell separation after cytokinesis." [PMID:25411334]


id: GO:1990816
name: vacuole-mitochondrion membrane contact site
namespace: cellular_component
def:
  "A zone of apposition between the vacuolar membrane and the mitochondrial outer membrane, important for transfer of lipids between the two organelles." [PMID:25026035, PMID:25026036]


id: GO:1990817
name: RNA adenylyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the template-independent extension of the 3'- end of an RNA strand by addition of one adenosine molecule at a time. Cannot initiate a chain 'de novo'. The primer, depending on the source of the enzyme, may be an RNA, or oligo(A) bearing a 3'-OH terminal group." [GOC:vw]


id: GO:1990818
name: L-arginine transmembrane export from vacuole
namespace: biological_process
def:
  "The directed movement of L-arginine out of the vacuole, across the vacuolar membrane." [PMID:26083598]


id: GO:1990819
name: actin fusion focus
namespace: cellular_component
def:
  "A focus at the mating projection tip where the cell wall is degraded during conjugation with cellular fusion. Actin filaments form an aster-like structure from this location." [PMID:25825517]


id: GO:1990820
name: response to mitotic DNA integrity checkpoint signaling
namespace: biological_process
def:
  "A process that occurs in response to signals generated as a result of mitotic DNA integrity checkpoint signaling." [PMID:7548844]


id: GO:1990821
name: high affinity glucose import
namespace: biological_process
def:
  "The directed, high-affinity movement of glucose into a cell by means of some agent such as a transporter or pore. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations." [PMID:25411338]


id: GO:1990822
name: basic amino acid transmembrane transport
namespace: biological_process
def:
  "The directed movement of basic amino acids from one side of a membrane to the other." [GOC:dph, GOC:vw]


id: GO:1990823
name: response to leukemia inhibitory factor
namespace: biological_process
def:
  "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a leukemia inhibitory factor stimulus." [PMID:12801913]


id: GO:1990824
name: obsolete magnesium-dependent protein complex
namespace: cellular_component
def:
  "OBSOLETE. A protein complex that depends on magnesium in order for one or more of its components to remain a part of the complex." [PMID:10220587]


id: GO:1990825
name: sequence-specific mRNA binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with messenger RNA (mRNA) of a specific nucleotide composition or a specific sequence motif." [PMID:11886857]


id: GO:1990827
name: deaminase binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with an enzyme that catalyzes the removal of an amino group from a substrate, producing ammonia (NH3)." [PMID:9792439]


id: GO:1990828
name: hepatocyte dedifferentiation
namespace: biological_process
def:
  "The process in which a hepatocyte (specialized epithelial cell of the liver) loses the structural or functional features that characterize it in the mature organism, or some other relatively stable phase of the organism's life history. Under certain conditions, these cells can revert back to the features of the stem cells that were their ancestors." [PMID:20102719]


id: GO:1990830
name: cellular response to leukemia inhibitory factor
namespace: biological_process
def:
  "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a leukemia inhibitory factor stimulus." [PMID:12801913]


id: GO:1990831
name: cellular response to carcinoembryonic antigen
namespace: biological_process
def:
  "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a carcinoembryonic antigen stimulus. The carcinoembryonic antigens represent a family of glycoproteins" [PMID:10202129, PMID:14597422]


id: GO:1990832
name: slow axonal transport
namespace: biological_process
def:
  "The directed slow movement of non-membranous molecules in nerve cell axons. It is comprised of a \"slow component a\" (SCa) and a \"slow component b\" (SCb) which differ in transport rates and protein composition." [PMID:6378920]


id: GO:1990833
name: clathrin-uncoating ATPase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: ATP + H2O = ADP + phosphate. Catalysis of the removal of clathrin from vesicle membranes, coupled to the hydrolysis of ATP." [PMID:6146630, PMID:8363588]


id: GO:1990834
name: response to odorant
namespace: biological_process
def:
  "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an odorant stimulus. An odorant is any substance capable of stimulating the sense of smell." [PMID:11268007]


id: GO:1990835
name: obsolete insulin-like growth factor production
namespace: biological_process
def:
  "OBSOLETE. The appearance of an insulin-like growth factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [PMID:21993393]


id: GO:1990836
name: lysosomal matrix
namespace: cellular_component
def:
  "A matrix composed of supramolecular assemblies of lysosomal enzymes and lipids which forms at a pH of 5.0 within the lysosome." [PMID:9395337]


id: GO:1990837
name: sequence-specific double-stranded DNA binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with double-stranded DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA, e.g. promotor binding or rDNA binding." [GOC:dos, GOC:sl]


id: GO:1990838
name: poly(U)-specific exoribonuclease activity, producing 3' uridine cyclic phosphate ends
namespace: molecular_function
def:
  "Catalysis of 3' exonucleolytic cleavage of poly(U), to form poly(U)-N containing a 3' uridine cyclic phosphate (U>P)." [PMID:23022480]


id: GO:1990839
name: response to endothelin
namespace: biological_process
def:
  "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an endothelin stimulus. Endothelin is any of three secretory vasoconstrictive peptides (endothelin-1, -2, -3)." [PMID:16365184]


id: GO:1990840
name: response to lectin
namespace: biological_process
def:
  "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lectin stimulus. A lectin is a carbohydrate-binding protein, highly specific for binding sugar moieties." [PMID:25996210, PMID:26306444]


id: GO:1990841
name: promoter-specific chromatin binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with a section of chromatin that is associated with gene promoter sequences of DNA." [PMID:19948729]


id: GO:1990842
name: obsolete response to prenatal stress
namespace: biological_process
def:
  "OBSOLETE. Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis in the embryo or fetus during pregnancy." [PMID:22738222]


id: GO:1990843
name: subsarcolemmal mitochondrion
namespace: cellular_component
def:
  "A mitochondrion that occurs adjacent to the sarcolemma in striated muscle cells and responds in distinct ways to physiological triggers." [PMID:23297307, PMID:26039174]


id: GO:1990844
name: interfibrillar mitochondrion
namespace: cellular_component
def:
  "A mitochondrion that occurs in between fibrils of striated muscle cells and responds in distinct ways to physiological triggers." [PMID:23297307, PMID:26039174]


id: GO:1990845
name: adaptive thermogenesis
namespace: biological_process
def:
  "The regulated production of heat in response to short term environmental changes, such as stress, diet or reduced temperature." [PMID:17260010, PMID:20363363]


id: GO:1990846
name: ribonucleoside-diphosphate reductase inhibitor activity
namespace: molecular_function
def:
  "Binds to and stops, prevents or reduces the activity of ribonucleoside-diphosphate reductase." [PMID:16317005]


id: GO:1990847
name: peptide pheromone transmembrane export involved in conjugation with cellular fusion
namespace: biological_process
def:
  "The directed movement of a peptide pheromone across a membrane and out of a cell by a secretion or export pathway used solely for the export of peptide pheromones that contributes to a conjugation process that results in the union of cellular and genetic information from compatible mating types." [PMID:9236781]


id: GO:1990848
name: obsolete Positive regulation of removal of reactive oxygen species
namespace: biological_process
def:
  "OBSOLETE. Any process that increases the frequency, rate or extent of removal of reactive oxygen species in a cell." [PMID:24118096]


id: GO:1990849
name: maintenance of vacuolar location
namespace: biological_process
def:
  "Any process in which the vacuole is maintained in a specific location within a cell and prevented from moving elsewhere." [PMID:26283797]


id: GO:1990850
name: H-gal-GP complex
namespace: cellular_component
def:
  "A membrane glycoprotein complex with aspartyl proteinase and metalloproteinase activity which is expressed in the gut. An example of this is found in the nematode Haemonchus contortus." [PMID:11166393]


id: GO:1990851
name: Wnt-Frizzled-LRP5/6 complex
namespace: cellular_component
def:
  "A protein complex containing a secreted Wnt protein associated with its receptor, Frizzled (Fz), and co-receptor low density lipoprotein receptor-related protein 5 (LRP5) or LRP6." [GOC:bf, GOC:PARL, PMID:11448771, PMID:20093360]


id: GO:1990852
name: protein transport along microtubule to spindle pole body
namespace: biological_process
def:
  "The directed movement of a protein along a microtubule to the spindle pole body, mediated by motor proteins." [PMID:25987607]


id: GO:1990853
name: histone H2A SQE motif phosphorylation
namespace: biological_process
def:
  "The modification of histone H2A by the addition of an phosphate group to the serine residue in the SQE motif of the histone." [DOI:10.1038/35052000, PMID:15226425]


id: GO:1990854
name: vacuole-ER tethering
namespace: biological_process
def:
  "The attachment of a lytic vacuole to the endoplasmic reticulum, which may facilitate exchange of metabolites between the organelles." [PMID:26283797]


id: GO:1990855
name: obsolete myo-inositol import across plasma membrane
namespace: biological_process
def:
  "OBSOLETE. The directed movement of myo-inositol from outside of a cell into the intracellular region of a cell across the plasma membrane." [PMID:9560432]


id: GO:1990856
name: methionyl-initiator methionine tRNA binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with methionine-initator methionine tRNA." [GOC:hjd, ISBN:9781555810733]


id: GO:1990857
name: APC-Fzr1/Mfr1 complex
namespace: cellular_component
def:
  "An anaphase promoting complex bound to an activator in the Fzr1 (human)/Mfr1 (pombe) family." [PMID:11493649]


id: GO:1990858
name: cellular response to lectin
namespace: biological_process
def:
  "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lectin stimulus. A lectin is a carbohydrate-binding protein, highly specific for binding sugar moieties." [PMID:25996210, PMID:26306444]


id: GO:1990859
name: cellular response to endothelin
namespace: biological_process
def:
  "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an endothelin stimulus. Endothelin is any of three secretory vasoconstrictive peptides (endothelin-1, -2, -3)." [PMID:16365184]


id: GO:1990860
name: Pho85-Pho80 CDK-cyclin complex
namespace: cellular_component
def:
  "A cyclin dependent kinase (CDK) complex that contains a kinase subunit and a regulatory cyclin subunit. An example of this complex in budding yeast S. cerevisiae consists of the Pho85 kinase and the Pho80 cyclin." [GOC:rb, PMID:8108735]


id: GO:1990861
name: Ubp3-Bre5 deubiquitination complex
namespace: cellular_component
def:
  "A protein complex that cleaves ubiquitin from specific substrates. In the budding yeast Saccharomyces cerevisiae, this complex consists of Ubp3p and Bre5p." [GOC:rb, PMID:12778054, PMID:18391941]


id: GO:1990862
name: nuclear membrane complex Bqt3-Bqt4
namespace: cellular_component
def:
  "A protein complex that resides in the inner nuclear membrane and anchors telomeres to the nuclear envelope. In fission yeast, it is composed of Bqt3 and Bqt4." [PMID:19948484]


id: GO:1990863
name: acinar cell proliferation
namespace: biological_process
def:
  "The multiplication or reproduction of acinar cells, resulting in the expansion of a cell population. An acinar cell is a secretory cell that is grouped together with other cells of the same type to form grape-shaped clusters known as acini (singular acinus)." [PMID:9788538]


id: GO:1990864
name: response to growth hormone-releasing hormone
namespace: biological_process
def:
  "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a growth hormone-releasing hormone stimulus. Growth hormone-releasing hormone regulates the release of growth hormone, as well as some pancreatic proteins, and possibly other proteins." [PMID:7720628]


id: GO:1990865
name: obsolete response to intermittent hypoxia
namespace: biological_process
def:
  "OBSOLETE. Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an episodic stimulus indicating lowered oxygen tension." [PMID:24055447]


id: GO:1990866
name: obsolete response to sustained hypoxia
namespace: biological_process
def:
  "OBSOLETE. Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a sustained stimulus indicating lowered oxygen tension." [PMID:24055447]


id: GO:1990867
name: response to gastrin
namespace: biological_process
def:
  "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gastrin stimulus." [PMID:10348814]


id: GO:1990868
name: response to chemokine
namespace: biological_process
def:
  "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemokine stimulus." [PMID:11113082]


id: GO:1990869
name: cellular response to chemokine
namespace: biological_process
def:
  "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemokine stimulus." [PMID:11113082]


id: GO:1990871
name: Vma12-Vma22 assembly complex
namespace: cellular_component
def:
  "A protein complex that is involved in the assembly of the V-ATPase complex. In the budding yeast Saccharomyces cerevisiae, this complex consists of Vma12p and Vma22p." [GOC:rb, PMID:9660861]


id: GO:1990872
namespace: biological_process
name:
  negative regulation of sterol import by negative regulation of transcription from RNA polymerase II promoter

def:
  "Any process that decreases the frequency, rate or extent of sterol import, by down regulation of transcription from an RNA polymerase II promoter." [GOC:rb, PMID:19793923]


id: GO:1990873
name: intrinsic component of plasma membrane of cell tip
namespace: cellular_component
def:
  "The component of the plasma membrane surrounding the cell tip consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the plasma membrane surrounding the cell tip or some other covalently attached group such as a GPI anchor that is similarly embedded in the plasma membrane surrounding the cell tip." [PMID:20624220]


id: GO:1990874
name: vascular smooth muscle cell proliferation
namespace: biological_process
def:
  "The multiplication or reproduction of vascular smooth muscle cells, resulting in the expansion of a cell population. A vascular smooth muscle cell is a non-striated, elongated, spindle-shaped cell found lining the blood vessels." [PMID:23246467]


id: GO:1990877
name: Lst4-Lst7 complex
namespace: cellular_component
def:
  "A heterodimeric complex that functions as a GTPase-Activating Protein (GAP) Complex for members of the Rag family of GTPases. In the budding yeast, this complex contains Lst4 and Lst7, while the orthologous mammalian complex contains Follicular (FLCN) and either follicular interaction protein 1 (FNIP1) or FNIP2." [GOC:rn, PMID:24095279, PMID:26387955]


id: GO:1990878
name: cellular response to gastrin
namespace: biological_process
def:
  "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gastrin stimulus." [PMID:10348814]


id: GO:1990879
name: CST complex
namespace: cellular_component
def:
  "A complex formed by the association of Cdc13 (CTC1 in mammals) with Stn1 in yeast (OBFC1 in mammals) and Ten1 protein (also TEN1 in mammals) with single-stranded telomeric DNA. The CST complex plays a role in telomere protection." [GOC:BHF, GOC:BHF_telomere, GOC:nc, IntAct:EBI-10043724, IntAct:EBI-8801830, IntAct:EBI-8801947, PMID:19854130, PMID:22965356]


id: GO:1990880
name: cellular detoxification of copper ion
namespace: biological_process
def:
  "Any process that reduces or removes the toxicity of copper ions in a cell. These include transport of copper cations away from sensitive areas and to compartments or complexes whose purpose is sequestration." [PMID:10369673]


id: GO:1990881
namespace: biological_process
name:
  obsolete negative regulation of transcription from RNA polymerase II promoter in response to DNA damage

def:
  "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of DNA damage." [PMID:26150418]


id: GO:1990882
name: rRNA acetylation
namespace: biological_process
def:
  "The modification of rRNA structure by addition of an acetyl group to rRNA. An acetyl group is CH3CO-, derived from acetic [ethanoic] acid." [PMID:25402480]


id: GO:1990883
name: rRNA cytidine N-acetyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: acetyl-CoA + cytidine = CoA + N4-acetylcytidine. The cytidine is within the polynucleotide chain of an rRNA." [PMID:25402480]


id: GO:1990884
name: RNA acetylation
namespace: biological_process
def:
  "The posttranscriptional addition of one or more acetyl groups to specific residues in an RNA molecule." [PMID:25402480]


id: GO:1990885
name: obsolete protein serine/threonine kinase binding
namespace: molecular_function
def:
  "OBSOLETE. Interacting selectively and non-covalently with a protein serine/threonine kinase." [PMID:16982699]


id: GO:1990886
name: 3,4-dihydroxy-5-polyprenylbenzoic acid O-methyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 3,4-dihydroxy-5-polyprenylbenzoic acid + S-adenosyl-L-methionine = 3-methoxy-4-hydroxy-5-polyprenylbenzoic acid + S-adenosyl-L-homocysteine + H+." [EC:2.1.1.114, PMID:10419476, RHEA:44455]


id: GO:1990887
name: 2-polyprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinol O-methyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 2-polyprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinol + S-adenosyl-L-methionine = ubiquinol-n + S-adenosyl-L-homocysteine + H+." [PMID:10419476]


id: GO:1990888
name: 2-polyprenyl-6-hydroxyphenol O-methyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 2-polyprenyl-6-hydroxyphenol + S-adenosyl-L-methionine = 2-polyprenyl-6-methoxyphenol + S-adenosyl-L-homocysteine + H+." [PMID:10419476]


id: GO:1990889
name: H4K20me3 modified histone binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with a histone H4 in which the lysine residue at position 20 has been modified by trimethylation." [PMID:22150589]


id: GO:1990891
name: mitotic sister chromatid arm separation
namespace: biological_process
def:
  "The cell cycle process in which sister chromatid arms are physically detached from each other during mitosis." [PMID:21633354]


id: GO:1990892
name: mitotic chromosome arm chromatin condensation
namespace: biological_process
def:
  "The cell cycle process in which chromosome arm chromatin structure is compacted prior to and during mitosis in eukaryotic cells." [PMID:21633354]


id: GO:1990893
name: mitotic chromosome centromere condensation
namespace: biological_process
def:
  "The cell cycle process in which centromere chromatin structure is compacted prior to and during mitosis." [PMID:21633354]


id: GO:1990894
namespace: biological_process
name:
  obsolete positive regulation of induction of conjugation with cellular fusion by regulation of transcription from RNA polymerase II promoter

def:
  "OBSOLETE. A regulation of transcription from RNA polymerase II promoter that results in positive regulation of induction of conjugation with cellular fusion." [PMID:22144909]


id: GO:1990895
name: regulation of protein localization to cell cortex of cell tip
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of protein localization to cell cortex of cell tip." [PMID:26150232\,GOC\:vw]


id: GO:1990896
name: protein localization to cell cortex of cell tip
namespace: biological_process
def:
  "A process in which a protein is transported to, or maintained in, the cell cortex of the cell tip." [PMID:26150232]


id: GO:1990897
name: obsolete CTDK-1 complex
namespace: cellular_component
def:
  "OBSOLETE. A protein complex that phosphorylates serine 2 residues in the CTD domain of productively elongating large subunits of DNA-directed RNA polymerase II, holoenzyme. In S. cerevisiae this complex consists of CTK1/CTK2/CTK3, in S. pombe Lsk1/Lsc1/Lsg1. Human CTK1 homologs include CDK12/13." [PMID:20952539, PMID:24879308]


id: GO:1990898
name: meiotic DNA double-strand break clipping
namespace: biological_process
def:
  "The process by which SPO11/Rec12-oligonucleotide complexes are removed from 5' DNA double-strand breaks induced during meiosis. Proteins involved in this process include the MRX/MRN complex and Sae2/Ctp1/RBBP8(CtIP)." [PMID:26130711]


id: GO:1990899
name: meiotic DNA double-strand break resectioning
namespace: biological_process
def:
  "The process following clipping in double-strand break processing of SPO11 induced breaks, where long-tract single-stranded 3'-end DNA is generated from naked (SPO11 has been removed) 5' ends." [PMID:26130711]


id: GO:1990900
name: ciliary pocket collar
namespace: cellular_component
def:
  "A constriction site at the junction of the plasma, flagellar and flagellar pocket membranes where the flagellum emerges from the cell body. Observed in some unicellular eukaryotic species such as Chlamydomonas, Giardia and Trypanosoma." [GOC:giardia, PMID:18462016, PMID:19806154]


id: GO:1990901
name: old cell pole
namespace: cellular_component
def:
  "The cell pole distal from the most recent cell division. In rod-shaped bacteria, some experiments distinguish between the old and new cell poles after cell division." [GOC:jh2, PMID:10231492, PMID:8226658]


id: GO:1990902
name: new cell pole
namespace: cellular_component
def:
  "The cell pole proximal to the most recent cell division. In rod-shaped bacteria, some experiments distinguish between the old and new cell poles after cell division." [GOC:jh2, PMID:10231492, PMID:8226658]


id: GO:1990905
name: dinoflagellate peduncle
namespace: cellular_component
def:
  "A small, flexible, finger-like appendage located near the flagellar pores in some photosynthetic as well as nonphotosynthetic dinoflagellate species. Its functions are not fully understood, but it has been associated with feeding behavior (phagotrophy)." [GOC:at, http://en.wikipedia.org/wiki/Dinoflagellate, http://species-identification.org/index.php]


id: GO:1990906
name: accessory outer segment
namespace: cellular_component
def:
  "A cilium-like cell projection emanating from the inner segment and running alongside the outer segment of photoreceptors." [GOC:dph, PMID:25125189]


id: GO:1990907
name: beta-catenin-TCF complex
namespace: cellular_component
def:
  "A protein complex that contains beta-catenin and a member of the T-cell factor (TCF)/lymphoid enhancer binding factor (LEF) family of transcription factors." [GOC:bf, GOC:PARL, IntAct:EBI-11424678, IntAct:EBI-11425837, PMID:11751639, PMID:16936075, PMID:20123964, PMID:21075118, PMID:9419974]


id: GO:1990908
name: obsolete Lys63-specific zinc metallopeptidase deubiquitinase activity
namespace: molecular_function
def:
  "OBSOLETE. Hydrolysis of Lys63-Linked ubiquitin unit(s) from a ubiquitinated protein by a mechanism where zinc acts as the nucleophile." [PMID:26368668]


id: GO:1990909
name: Wnt signalosome
namespace: cellular_component
def:
  "A multiprotein protein complex containing membrane-localized Wnt receptors and cytosolic protein complexes, which is capable of transmitting the Wnt signal. Contains at least a Wnt protein, LRP5 or LRP6, a member of the Frizzled (Fz) family, Axin and and a Dishevelled (DVL) protein." [GOC:bf, GOC:PARL, PMID:22899650, PMID:25336320]


id: GO:1990910
name: response to hypobaric hypoxia
namespace: biological_process
def:
  "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension combined with low atmospheric pressure. Hypoxia is defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95% and hypobaric is defined as atmospheric pressure below 0.74 atm (greater than 2,500 m above sea level)." [PMID:24590457]


id: GO:1990911
name: response to psychosocial stress
namespace: biological_process
def:
  "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of exposure to aversive or demanding psychological and social conditions that tax or exceed the behavioral resources of the organism." [PMID:22922217, PMID:26458179]


id: GO:1990912
name: obsolete response to microwave radiation
namespace: biological_process
def:
  "OBSOLETE. Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a microwave radiation stimulus." [PMID:21241601]


id: GO:1990914
name: integral component of periplasmic side of plasma membrane
namespace: cellular_component
def:
  "The component of the plasma membrane consisting of the gene products that penetrate only the periplasmic side of the membrane." [GOC:bhm, IntAct:EBI-11297444, PMID:15919996]


id: GO:1990915
name: structural constituent of ascospore wall
namespace: molecular_function
def:
  "The action of a molecule that contributes to the structural integrity of an ascospore wall." [PMID:24623719]


id: GO:1990916
name: Isp3 layer of spore wall
namespace: cellular_component
def:
  "The outermost layers of the spore wall, as described in Schizosaccharomyces pombe." [PMID:24623719]


id: GO:1990918
name: double-strand break repair involved in meiotic recombination
namespace: biological_process
def:
  "The repair of double-strand breaks in DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix that contributes to reciprocal meiotic recombination." [GOC:mah, PMID:15238514]


id: GO:1990919
name: nuclear membrane proteasome anchor
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with a proteasome complex and a nuclear inner membrane, in order to maintain the nuclear membrane localization of the proteasome." [PMID:16096059]


id: GO:1990920
name: proteasome localization to nuclear periphery
namespace: biological_process
def:
  "Any process in which the proteasome is transported to, or maintained at the nuclear periphery." [PMID:11084332]


id: GO:1990921
name: obsolete proteasome localization to nuclear periphery
namespace: biological_process
def:
  "OBSOLETE. A process in which a proteasome is transported to, or maintained in, a location within the nuclear periphery." [PMID:16096059]


id: GO:1990922
name: hepatic stellate cell proliferation
namespace: biological_process
def:
  "The multiplication or reproduction of hepatic stellate cells, resulting in the expansion of a hepatic stellate cell population. Hepatic stellate cells are found in the perisinusoidal space of the liver, and are capable of multiple roles including storage of retinol, presentation of antigen to T cells (including CD1d-restricted NKT cells), and upon activation, production of extracellular matrix components. This cell type comprises approximately 8-15% of total cells in the liver." [GOC:sl, PMID:15358192, PMID:18466260]


id: GO:1990923
name: PET complex
namespace: cellular_component
def:
  "A protein complex that is composed of at least EXD1, TDRD12 and some PIWI protein. The complex is required for MILI slicing-triggered biogenesis and loading of MIWI2 piRNAs" [PMID:26669262]


id: GO:1990924
name: obsolete amphisome membrane
namespace: cellular_component
def:
  "OBSOLETE. The lipid bilayer surrounding the amphisome and separating its contents from the cell cytoplasm." [GOC:bhm, PMID:17984323]


id: GO:1990925
name: mitochondrial iron ion transmembrane transport
namespace: biological_process
def:
  "The directed movement of iron ions from one side of a membrane into, out of or within a mitochondrion." [PMID:12902335]


id: GO:1990927
name: calcium ion regulated lysosome exocytosis
namespace: biological_process
def:
  "The process of secretion by a cell that results in the release of intracellular molecules contained within a lysosome by fusion of the vesicle with the plasma membrane of a cell, induced by a rise in cytosolic calcium-ion levels." [PMID:10725327, PMID:11511344]


id: GO:1990928
name: response to amino acid starvation
namespace: biological_process
def:
  "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of amino acids." [PMID:7765311]


id: GO:1990929
name: sulfoquinovosidase activity
namespace: molecular_function
def:
  "Catalyzes the hydrolysis of terminal non-reducing alpha-sulfoquinovoside residues in alpha-sulfoquinovosyl diacylglycerides and alpha-sulfoquinovosyl glycerol, generating alpha-sulfoquinovose." [GOC:imk, PMID:26878550]


id: GO:2000002
name: negative regulation of DNA damage checkpoint
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of a DNA damage checkpoint." [GOC:BHF, GOC:obol]


id: GO:2000003
name: positive regulation of DNA damage checkpoint
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of a DNA damage checkpoint." [GOC:obol]


id: GO:2000004
name: regulation of metanephric S-shaped body morphogenesis
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of metanephric S-shaped body morphogenesis." [GOC:mtg_kidney_jan10, GOC:obol, GOC:yaf]


id: GO:2000005
name: negative regulation of metanephric S-shaped body morphogenesis
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of metanephric S-shaped body morphogenesis." [GOC:mtg_kidney_jan10, GOC:obol, GOC:yaf]


id: GO:2000006
name: regulation of metanephric comma-shaped body morphogenesis
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of metanephric comma-shaped body morphogenesis." [GOC:mtg_kidney_jan10, GOC:obol, GOC:yaf]


id: GO:2000007
name: negative regulation of metanephric comma-shaped body morphogenesis
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of metanephric comma-shaped body morphogenesis." [GOC:mtg_kidney_jan10, GOC:obol, GOC:yaf]


id: GO:2000008
name: regulation of protein localization to cell surface
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of protein localization to the cell surface." [GOC:obol]


id: GO:2000009
name: negative regulation of protein localization to cell surface
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of protein localization to the cell surface." [GOC:obol]


id: GO:2000010
name: positive regulation of protein localization to cell surface
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of protein localization to the cell surface." [GOC:obol]


id: GO:2000011
name: regulation of adaxial/abaxial pattern formation
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of adaxial/abaxial pattern formation." [GOC:obol]


id: GO:2000013
name: regulation of arginine biosynthetic process via ornithine
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of arginine biosynthetic process via ornithine." [GOC:obol]


id: GO:2000015
name: regulation of determination of dorsal identity
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of determination of dorsal identity." [GOC:obol]


id: GO:2000016
name: negative regulation of determination of dorsal identity
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of determination of dorsal identity." [GOC:BHF, GOC:obol]


id: GO:2000017
name: positive regulation of determination of dorsal identity
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of determination of dorsal identity." [GOC:obol]


id: GO:2000018
name: regulation of male gonad development
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of male gonad development." [GOC:obol, GOC:yaf]


id: GO:2000019
name: negative regulation of male gonad development
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of male gonad development." [GOC:obol, GOC:yaf]


id: GO:2000020
name: positive regulation of male gonad development
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of male gonad development." [GOC:obol]


id: GO:2000022
name: regulation of jasmonic acid mediated signaling pathway
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of jasmonic acid mediated signaling pathway." [GOC:obol]


id: GO:2000026
name: regulation of multicellular organismal development
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of multicellular organismal development." [GOC:obol]


id: GO:2000029
name: regulation of proanthocyanidin biosynthetic process
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of proanthocyanidin biosynthetic process." [GOC:obol]


id: GO:2000030
name: regulation of response to red or far red light
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of response to red or far red light." [GOC:obol]


id: GO:2000031
name: regulation of salicylic acid mediated signaling pathway
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of salicylic acid mediated signaling pathway." [GOC:obol]


id: GO:2000033
name: regulation of seed dormancy process
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of seed dormancy process." [GOC:obol, GOC:pr, ISBN:9781405139830]


id: GO:2000036
name: regulation of stem cell population maintenance
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of stem cell population maintenance." [GOC:obol]


id: GO:2000037
name: regulation of stomatal complex patterning
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of stomatal complex patterning." [GOC:obol]


id: GO:2000038
name: regulation of stomatal complex development
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of stomatal complex development." [GOC:obol]


id: GO:2000040
name: regulation of planar cell polarity pathway involved in axis elongation
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of planar cell polarity pathway involved in axis elongation." [GOC:dph]


id: GO:2000041
name: negative regulation of planar cell polarity pathway involved in axis elongation
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of planar cell polarity pathway involved in axis elongation." [GOC:dph]


id: GO:2000042
name: negative regulation of double-strand break repair via homologous recombination
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of double-strand break repair via homologous recombination." [GOC:vw]


id: GO:2000043
name: regulation of cardiac cell fate specification
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of cardiac cell fate specification." [GOC:BHF]


id: GO:2000044
name: negative regulation of cardiac cell fate specification
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of cardiac cell fate specification." [GOC:BHF]


id: GO:2000045
name: regulation of G1/S transition of mitotic cell cycle
namespace: biological_process
def:
  "Any cell cycle regulatory process that controls the commitment of a cell from G1 to S phase of the mitotic cell cycle." [GOC:mtg_cell_cycle]


id: GO:2000046
name: obsolete regulation of G2 phase of mitotic cell cycle
namespace: biological_process
def:
  "OBSOLETE. Any process that modulates the frequency, rate or extent of G2 phase of mitotic cell cycle." [GOC:mtg_cell_cycle, GOC:vw]


id: GO:2000047
name: regulation of cell-cell adhesion mediated by cadherin
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of cell-cell adhesion mediated by cadherin." [GOC:obol]


id: GO:2000048
name: negative regulation of cell-cell adhesion mediated by cadherin
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of cell-cell adhesion mediated by cadherin." [GOC:obol]


id: GO:2000049
name: positive regulation of cell-cell adhesion mediated by cadherin
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of cell-cell adhesion mediated by cadherin." [GOC:obol]


id: GO:2000050
name: regulation of non-canonical Wnt signaling pathway
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of non-canonical Wnt signaling pathway." [GOC:obol, GOC:yaf]


id: GO:2000051
name: negative regulation of non-canonical Wnt signaling pathway
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of non-canonical Wnt signaling pathway." [GOC:obol, GOC:yaf]


id: GO:2000052
name: positive regulation of non-canonical Wnt signaling pathway
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of non-canonical Wnt-activated signaling pathway." [GOC:obol, GOC:yaf]


id: GO:2000053
name: regulation of Wnt signaling pathway involved in dorsal/ventral axis specification
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of Wnt signaling pathway involved in dorsal/ventral axis specification." [GOC:obol, GOC:yaf]


id: GO:2000054
name: negative regulation of Wnt signaling pathway involved in dorsal/ventral axis specification
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of Wnt signaling pathway involved in dorsal/ventral axis specification." [GOC:obol, GOC:yaf]


id: GO:2000055
name: positive regulation of Wnt signaling pathway involved in dorsal/ventral axis specification
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of Wnt signaling pathway involved in dorsal/ventral axis specification." [GOC:obol]


id: GO:2000056
name: regulation of Wnt signaling pathway involved in digestive tract morphogenesis
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of Wnt signaling pathway involved in digestive tract morphogenesis." [GOC:obol]


id: GO:2000057
name: negative regulation of Wnt signaling pathway involved in digestive tract morphogenesis
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of Wnt signaling pathway involved in digestive tract morphogenesis." [GOC:obol]


id: GO:2000058
name: regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of protein ubiquitination involved in ubiquitin-dependent protein catabolic process." [GOC:BHF]


id: GO:2000059
namespace: biological_process
name:
  negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process

def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of protein ubiquitination involved in ubiquitin-dependent protein catabolic process." [GOC:BHF]


id: GO:2000060
namespace: biological_process
name:
  positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process

def:
  "Any process that activates or increases the frequency, rate or extent of protein ubiquitination involved in ubiquitin-dependent protein catabolic process." [GOC:BHF]


id: GO:2000061
name: regulation of ureter smooth muscle cell differentiation
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of ureter smooth muscle cell differentiation." [GOC:mtg_kidney_jan10, GOC:obol, GOC:yaf]


id: GO:2000062
name: negative regulation of ureter smooth muscle cell differentiation
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of ureter smooth muscle cell differentiation." [GOC:mtg_kidney_jan10, GOC:obol, GOC:yaf]


id: GO:2000063
name: positive regulation of ureter smooth muscle cell differentiation
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of ureter smooth muscle cell differentiation." [GOC:mtg_kidney_jan10, GOC:obol, GOC:yaf]


id: GO:2000064
name: regulation of cortisol biosynthetic process
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of cortisol biosynthetic process." [GOC:obol, GOC:yaf]


id: GO:2000065
name: negative regulation of cortisol biosynthetic process
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of cortisol biosynthetic process." [GOC:obol, GOC:yaf]


id: GO:2000066
name: positive regulation of cortisol biosynthetic process
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of cortisol biosynthetic process." [GOC:obol, GOC:yaf]


id: GO:2000068
name: regulation of defense response to insect
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of defense response to insect." [GOC:obol]


id: GO:2000069
name: regulation of post-embryonic root development
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of post-embryonic root development." [GOC:obol]


id: GO:2000070
name: regulation of response to water deprivation
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of response to water deprivation." [GOC:obol]


id: GO:2000071
name: regulation of defense response by callose deposition
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of defense response by callose deposition." [GOC:obol]


id: GO:2000072
name: regulation of defense response to fungus, incompatible interaction
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of defense response to fungus, incompatible interaction." [GOC:obol]


id: GO:2000073
name: regulation of cytokinesis, site selection
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of site selection that occurs as part of cytokinesis." [GOC:mtg_cell_cycle, GOC:obol]


id: GO:2000074
name: regulation of type B pancreatic cell development
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of pancreatic B cell development." [GOC:obol, GOC:yaf]


id: GO:2000075
name: negative regulation of cytokinesis, site selection
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of site selection that occurs as part of cytokinesis." [GOC:mtg_cell_cycle, GOC:obol]


id: GO:2000076
name: positive regulation cytokinesis, site selection
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of site selection that occurs as part of cytokinesis." [GOC:mtg_cell_cycle, GOC:obol]


id: GO:2000077
name: negative regulation of type B pancreatic cell development
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of pancreatic B cell development." [GOC:obol, GOC:yaf]


id: GO:2000078
name: positive regulation of type B pancreatic cell development
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of pancreatic B cell development." [GOC:obol, GOC:yaf]


id: GO:2000079
namespace: biological_process
name:
  regulation of canonical Wnt signaling pathway involved in controlling type B pancreatic cell proliferation

def:
  "Any process that modulates the frequency, rate or extent of canonical Wnt signaling pathway modulating the rate or frequency of pancreatic B cell proliferation." [GOC:obol, GOC:yaf]


id: GO:2000080
namespace: biological_process
name:
  negative regulation of canonical Wnt signaling pathway involved in controlling type B pancreatic cell proliferation

def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of canonical Wnt signaling pathway modulating the rate or frequency of pancreatic B cell proliferation." [GOC:obol, GOC:yaf]


id: GO:2000081
namespace: biological_process
name:
  positive regulation of canonical Wnt signaling pathway involved in controlling type B pancreatic cell proliferation

def:
  "Any process that activates or increases the frequency, rate or extent of canonical Wnt signaling pathway modulating the rate or frequency of pancreatic B cell proliferation." [GOC:obol, GOC:yaf]


id: GO:2000082
name: regulation of L-ascorbic acid biosynthetic process
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of L-ascorbic acid biosynthetic process." [PMID:19395407]


id: GO:2000083
name: negative regulation of L-ascorbic acid biosynthetic process
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of L-ascorbic acid biosynthetic process." [PMID:19395407]


id: GO:2000084
name: regulation of mesenchymal to epithelial transition involved in mesonephros morphogenesis
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of mesenchymal to epithelial transition involved in mesonephros morphogenesis." [GOC:mtg_kidney_jan10]


id: GO:2000085
name: negative regulation of mesenchymal to epithelial transition involved in mesonephros morphogenesis
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of mesenchymal to epithelial transition involved in mesonephros morphogenesis." [GOC:mtg_kidney_jan10]


id: GO:2000086
name: positive regulation of mesenchymal to epithelial transition involved in mesonephros morphogenesis
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of mesenchymal to epithelial transition involved in mesonephros morphogenesis." [GOC:mtg_kidney_jan10]


id: GO:2000087
name: regulation of mesonephric glomerulus development
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of mesonephric glomerulus development." [GOC:mtg_kidney_jan10]


id: GO:2000088
name: negative regulation of mesonephric glomerulus development
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of mesonephric glomerulus development." [GOC:mtg_kidney_jan10]


id: GO:2000089
name: positive regulation of mesonephric glomerulus development
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of mesonephric glomerulus development." [GOC:mtg_kidney_jan10]


id: GO:2000090
name: regulation of mesonephric glomerular mesangial cell proliferation
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of mesonephric glomerular mesangial cell proliferation." [GOC:mtg_kidney_jan10]


id: GO:2000091
name: negative regulation of mesonephric glomerular mesangial cell proliferation
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of mesonephric glomerular mesangial cell proliferation." [GOC:mtg_kidney_jan10]


id: GO:2000092
name: positive regulation of mesonephric glomerular mesangial cell proliferation
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of mesonephric glomerular mesangial cell proliferation." [GOC:mtg_kidney_jan10]


id: GO:2000093
name: regulation of mesonephric nephron tubule epithelial cell differentiation
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of mesonephric nephron tubule epithelial cell differentiation." [GOC:mtg_kidney_jan10]


id: GO:2000094
name: negative regulation of mesonephric nephron tubule epithelial cell differentiation
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of mesonephric nephron tubule epithelial cell differentiation." [GOC:mtg_kidney_jan10]


id: GO:2000095
name: regulation of Wnt signaling pathway, planar cell polarity pathway
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of Wnt signaling pathway, planar cell polarity pathway." [GOC:BHF]


id: GO:2000096
name: positive regulation of Wnt signaling pathway, planar cell polarity pathway
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of Wnt signaling pathway, planar cell polarity pathway." [GOC:BHF]


id: GO:2000097
name: regulation of smooth muscle cell-matrix adhesion
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of smooth muscle cell-matrix adhesion." [GOC:BHF]


id: GO:2000098
name: negative regulation of smooth muscle cell-matrix adhesion
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of smooth muscle cell-matrix adhesion." [GOC:BHF]


id: GO:2000099
name: regulation of establishment or maintenance of bipolar cell polarity
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of establishment or maintenance of bipolar cell polarity." [GOC:obol]


id: GO:2000100
name: regulation of establishment or maintenance of bipolar cell polarity regulating cell shape
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of establishment or maintenance of bipolar cell polarity regulating cell shape." [GOC:obol]


id: GO:2000101
name: regulation of mammary stem cell proliferation
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of mammary stem cell proliferation." [GOC:obol]


id: GO:2000102
name: negative regulation of mammary stem cell proliferation
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of mammary stem cell proliferation." [GOC:obol]


id: GO:2000103
name: positive regulation of mammary stem cell proliferation
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of mammary stem cell proliferation." [GOC:obol]


id: GO:2000104
name: negative regulation of DNA-dependent DNA replication
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of DNA-dependent DNA replication." [GOC:mah]


id: GO:2000105
name: positive regulation of DNA-dependent DNA replication
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of DNA-dependent DNA replication." [GOC:mah]


id: GO:2000106
name: regulation of leukocyte apoptotic process
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of leukocyte apoptotic process." [GOC:BHF, GOC:mtg_apoptosis]


id: GO:2000107
name: negative regulation of leukocyte apoptotic process
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of leukocyte apoptotic process." [GOC:BHF, GOC:mtg_apoptosis]


id: GO:2000108
name: positive regulation of leukocyte apoptotic process
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of leukocyte apoptotic process." [GOC:BHF, GOC:mtg_apoptosis]


id: GO:2000109
name: regulation of macrophage apoptotic process
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of macrophage apoptotic process." [GOC:BHF, GOC:mtg_apoptosis]


id: GO:2000110
name: negative regulation of macrophage apoptotic process
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of macrophage apoptotic process." [GOC:BHF, GOC:mtg_apoptosis]


id: GO:2000111
name: positive regulation of macrophage apoptotic process
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of macrophage apoptotic process." [GOC:BHF, GOC:mtg_apoptosis]


id: GO:2000112
name: regulation of cellular macromolecule biosynthetic process
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of cellular macromolecule biosynthetic process." [GOC:obol]


id: GO:2000113
name: negative regulation of cellular macromolecule biosynthetic process
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of cellular macromolecule biosynthetic process." [GOC:obol]


id: GO:2000114
name: regulation of establishment of cell polarity
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of establishment of cell polarity." [GOC:dph]


id: GO:2000115
name: regulation of maintenance of bipolar cell polarity regulating cell shape
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of maintenance of bipolar cell polarity regulating in cell shape." [GOC:obol]


id: GO:2000116
name: regulation of cysteine-type endopeptidase activity
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of cysteine-type endopeptidase activity." [GOC:obol, GOC:yaf]


id: GO:2000117
name: negative regulation of cysteine-type endopeptidase activity
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of cysteine-type endopeptidase activity." [GOC:obol, GOC:yaf]


id: GO:2000118
name: regulation of sodium-dependent phosphate transport
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of sodium-dependent phosphate transport." [GOC:BHF]


id: GO:2000119
name: negative regulation of sodium-dependent phosphate transport
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of sodium-dependent phosphate transport." [GOC:BHF]


id: GO:2000120
name: positive regulation of sodium-dependent phosphate transport
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of sodium-dependent phosphate transport." [GOC:BHF]


id: GO:2000121
name: regulation of removal of superoxide radicals
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of removal of superoxide radicals." [GOC:obol]


id: GO:2000122
name: negative regulation of stomatal complex development
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of stomatal complex development." [GOC:obol]


id: GO:2000123
name: positive regulation of stomatal complex development
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of stomatal complex development." [GOC:obol]


id: GO:2000124
name: regulation of endocannabinoid signaling pathway
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of endocannabinoid signaling pathway." [GOC:mah, PMID:15550444]


id: GO:2000125
name: regulation of octopamine or tyramine signaling pathway
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of octopamine or tyramine signaling pathway." [GOC:mah]


id: GO:2000126
name: negative regulation of octopamine or tyramine signaling pathway
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of octopamine or tyramine signaling pathway." [GOC:mah]


id: GO:2000127
name: positive regulation of octopamine or tyramine signaling pathway
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of octopamine or tyramine signaling pathway." [GOC:mah]


id: GO:2000128
name: regulation of octopamine signaling pathway
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of octopamine signaling pathway." [GOC:mah]


id: GO:2000129
name: negative regulation of octopamine signaling pathway
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of octopamine signaling pathway." [GOC:mah]


id: GO:2000130
name: positive regulation of octopamine signaling pathway
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of octopamine signaling pathway." [GOC:mah]


id: GO:2000132
name: negative regulation of tyramine signaling pathway
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of tyramine signaling pathway." [GOC:mah]


id: GO:2000133
name: positive regulation of tyramine signaling pathway
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of tyramine signaling pathway." [GOC:mah]


id: GO:2000134
name: negative regulation of G1/S transition of mitotic cell cycle
namespace: biological_process
def:
  "Any cell cycle regulatory process that prevents the commitment of a cell from G1 to S phase of the mitotic cell cycle." [GOC:mtg_cell_cycle]


id: GO:2000135
name: obsolete positive regulation of regulation of secondary heart field cardioblast proliferation
namespace: biological_process
def:
  "OBSOLETE. Any process that activates or increases the frequency, rate or extent of regulation of secondary heart field cardioblast proliferation." [GOC:dph]


id: GO:2000136
name: regulation of cell proliferation involved in heart morphogenesis
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of cell proliferation involved in heart morphogenesis." [GOC:dph]


id: GO:2000137
name: negative regulation of cell proliferation involved in heart morphogenesis
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of cell proliferation involved in heart morphogenesis." [GOC:dph]


id: GO:2000138
name: positive regulation of cell proliferation involved in heart morphogenesis
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of cell proliferation involved in heart morphogenesis." [GOC:dph]


id: GO:2000139
name: regulation of octopamine signaling pathway involved in response to food
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of octopamine signaling pathway involved in response to food." [GOC:mah, PMID:19609300]


id: GO:2000140
name: negative regulation of octopamine signaling pathway involved in response to food
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of octopamine signaling pathway involved in response to food." [GOC:mah, PMID:19609300]


id: GO:2000141
name: positive regulation of octopamine signaling pathway involved in response to food
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of octopamine signaling pathway involved in response to food." [GOC:mah, PMID:19609300]


id: GO:2000142
name: regulation of DNA-templated transcription, initiation
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of DNA-templated transcription initiation." [GOC:mah, GOC:txnOH]


id: GO:2000143
name: negative regulation of DNA-templated transcription, initiation
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of DNA-templated transcription initiation." [GOC:mah, GOC:txnOH]


id: GO:2000144
name: positive regulation of DNA-templated transcription, initiation
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of DNA-templated transcription initiation." [GOC:mah, GOC:txnOH]


id: GO:2000146
name: negative regulation of cell motility
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of cell motility." [GOC:mah]


id: GO:2000148
name: regulation of planar cell polarity pathway involved in ventricular septum morphogenesis
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of planar cell polarity pathway involved in ventricular septum morphogenesis." [GOC:dph]


id: GO:2000149
name: negative regulation of planar cell polarity pathway involved in ventricular septum morphogenesis
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of planar cell polarity pathway involved in ventricular septum morphogenesis." [GOC:dph]


id: GO:2000150
name: regulation of planar cell polarity pathway involved in cardiac muscle tissue morphogenesis
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of planar cell polarity pathway involved in cardiac muscle tissue morphogenesis." [GOC:dph]


id: GO:2000151
name: negative regulation of planar cell polarity pathway involved in cardiac muscle tissue morphogenesis
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of planar cell polarity pathway involved in cardiac muscle tissue morphogenesis." [GOC:dph]


id: GO:2000152
name: regulation of ubiquitin-specific protease activity
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of regulation of ubiquitin-specific protease activity (deubiquitinase) activity." [GOC:obol]


id: GO:2000153
name: obsolete regulation of flagellar cell motility
namespace: biological_process
def:
  "OBSOLETE. Any process that modulates the frequency, rate or extent of flagellar cell motility." [GOC:mah]


id: GO:2000154
name: obsolete negative regulation of flagellar cell motility
namespace: biological_process
def:
  "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of flagellar cell motility." [GOC:mah]


id: GO:2000155
name: positive regulation of cilium-dependent cell motility
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of cilium-dependent cell motility." [GOC:cilia, GOC:jl]


id: GO:2000156
name: regulation of retrograde vesicle-mediated transport, Golgi to ER
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of retrograde vesicle-mediated transport, Golgi to ER." [GOC:mah]


id: GO:2000157
name: negative regulation of ubiquitin-specific protease activity
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of ubiquitin-specific protease (deubiquitinase) activity." [GOC:obol]


id: GO:2000158
name: positive regulation of ubiquitin-specific protease activity
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of ubiquitin-specific protease (deubiquitinase) activity." [GOC:obol]


id: GO:2000159
name: regulation of planar cell polarity pathway involved in heart morphogenesis
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of planar cell polarity pathway involved in heart morphogenesis." [GOC:dph]


id: GO:2000160
name: negative regulation of planar cell polarity pathway involved in heart morphogenesis
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of planar cell polarity pathway involved in heart morphogenesis." [GOC:dph]


id: GO:2000161
name: regulation of planar cell polarity pathway involved in cardiac right atrium morphogenesis
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of planar cell polarity pathway involved in cardiac right atrium morphogenesis." [GOC:dph]


id: GO:2000162
name: negative regulation of planar cell polarity pathway involved in cardiac right atrium morphogenesis
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of planar cell polarity pathway involved in cardiac right atrium morphogenesis." [GOC:dph]


id: GO:2000163
name: regulation of planar cell polarity pathway involved in outflow tract morphogenesis
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of planar cell polarity pathway involved in outflow tract morphogenesis." [GOC:dph]


id: GO:2000164
name: negative regulation of planar cell polarity pathway involved in outflow tract morphogenesis
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of planar cell polarity pathway involved in outflow tract morphogenesis." [GOC:dph]


id: GO:2000165
name: regulation of planar cell polarity pathway involved in pericardium morphogenesis
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of planar cell polarity pathway involved in pericardium morphogenesis." [GOC:dph]


id: GO:2000166
name: negative regulation of planar cell polarity pathway involved in pericardium morphogenesis
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of planar cell polarity pathway involved in pericardium morphogenesis." [GOC:dph]


id: GO:2000167
name: regulation of planar cell polarity pathway involved in neural tube closure
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of planar cell polarity pathway involved in neural tube closure." [GOC:dph]


id: GO:2000168
name: negative regulation of planar cell polarity pathway involved in neural tube closure
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of planar cell polarity pathway involved in neural tube closure." [GOC:dph]


id: GO:2000169
name: regulation of peptidyl-cysteine S-nitrosylation
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of peptidyl-cysteine S-nitrosylation." [GOC:obol]


id: GO:2000170
name: positive regulation of peptidyl-cysteine S-nitrosylation
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of peptidyl-cysteine S-nitrosylation." [GOC:obol]


id: GO:2000171
name: negative regulation of dendrite development
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of dendrite development." [GOC:obol]


id: GO:2000172
name: regulation of branching morphogenesis of a nerve
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of branching morphogenesis of a nerve." [GOC:BHF]


id: GO:2000173
name: negative regulation of branching morphogenesis of a nerve
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of branching morphogenesis of a nerve." [GOC:BHF]


id: GO:2000175
name: negative regulation of pro-T cell differentiation
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of pro-T cell differentiation." [GOC:BHF]


id: GO:2000176
name: positive regulation of pro-T cell differentiation
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of pro-T cell differentiation." [GOC:BHF]


id: GO:2000177
name: regulation of neural precursor cell proliferation
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of neural precursor cell proliferation." [GOC:dph, GOC:yaf]


id: GO:2000178
name: negative regulation of neural precursor cell proliferation
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of neural precursor cell proliferation." [GOC:dph, GOC:yaf]


id: GO:2000179
name: positive regulation of neural precursor cell proliferation
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of neural precursor cell proliferation." [GOC:dph, GOC:yaf]


id: GO:2000180
name: negative regulation of androgen biosynthetic process
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of androgen biosynthetic process." [GOC:dph, GOC:yaf]


id: GO:2000181
name: negative regulation of blood vessel morphogenesis
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of blood vessel morphogenesis." [GOC:dph, GOC:yaf]


id: GO:2000182
name: regulation of progesterone biosynthetic process
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of progesterone biosynthetic process." [GOC:dph]


id: GO:2000183
name: negative regulation of progesterone biosynthetic process
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of progesterone biosynthetic process." [GOC:dph]


id: GO:2000184
name: positive regulation of progesterone biosynthetic process
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of progesterone biosynthetic process." [GOC:dph]


id: GO:2000185
name: regulation of phosphate transmembrane transport
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of phosphate transmembrane transport." [GOC:obol]


id: GO:2000186
name: negative regulation of phosphate transmembrane transport
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of phosphate transmembrane transport." [GOC:obol]


id: GO:2000187
name: positive regulation of phosphate transmembrane transport
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of phosphate transmembrane transport." [GOC:obol]


id: GO:2000189
name: positive regulation of cholesterol homeostasis
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of cholesterol homeostasis." [GOC:BHF]


id: GO:2000190
namespace: biological_process
name:
  obsolete negative regulation of regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor

def:
  "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor." [GOC:BHF]


id: GO:2000192
name: negative regulation of fatty acid transport
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of fatty acid transport." [GOC:BHF]


id: GO:2000193
name: positive regulation of fatty acid transport
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of fatty acid transport." [GOC:BHF]


id: GO:2000195
name: negative regulation of female gonad development
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of female gonad development." [GOC:obol]


id: GO:2000196
name: positive regulation of female gonad development
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of female gonad development." [GOC:obol]


id: GO:2000197
name: regulation of ribonucleoprotein complex localization
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of ribonucleoprotein complex localization." [GOC:mah]


id: GO:2000198
name: negative regulation of ribonucleoprotein complex localization
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of ribonucleoprotein complex localization." [GOC:mah]


id: GO:2000199
name: positive regulation of ribonucleoprotein complex localization
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of ribonucleoprotein complex localization." [GOC:mah]


id: GO:2000200
name: regulation of ribosomal subunit export from nucleus
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of ribosomal subunit export from nucleus." [GOC:mah]


id: GO:2000201
name: negative regulation of ribosomal subunit export from nucleus
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of ribosomal subunit export from nucleus." [GOC:mah]


id: GO:2000202
name: positive regulation of ribosomal subunit export from nucleus
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of ribosomal subunit export from nucleus." [GOC:mah]


id: GO:2000203
name: regulation of ribosomal large subunit export from nucleus
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of ribosomal large subunit export from nucleus." [GOC:mah]


id: GO:2000204
name: negative regulation of ribosomal large subunit export from nucleus
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of ribosomal large subunit export from nucleus." [GOC:mah]


id: GO:2000205
name: positive regulation of ribosomal large subunit export from nucleus
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of ribosomal large subunit export from nucleus." [GOC:mah]


id: GO:2000206
name: regulation of ribosomal small subunit export from nucleus
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of ribosomal small subunit export from nucleus." [GOC:mah]


id: GO:2000207
name: negative regulation of ribosomal small subunit export from nucleus
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of ribosomal small subunit export from nucleus." [GOC:mah]


id: GO:2000208
name: positive regulation of ribosomal small subunit export from nucleus
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of ribosomal small subunit export from nucleus." [GOC:mah]


id: GO:2000212
name: negative regulation of glutamate metabolic process
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of glutamate metabolic process." [GOC:sl]


id: GO:2000213
name: positive regulation of glutamate metabolic process
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of glutamate metabolic process." [GOC:sl]


id: GO:2000215
name: negative regulation of proline metabolic process
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of proline metabolic process." [GOC:sl]


id: GO:2000216
name: positive regulation of proline metabolic process
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of proline metabolic process." [GOC:sl]


id: GO:2000217
name: regulation of invasive growth in response to glucose limitation
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of invasive growth in response to glucose limitation." [GOC:mah]


id: GO:2000218
name: negative regulation of invasive growth in response to glucose limitation
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of invasive growth in response to glucose limitation." [GOC:mah]


id: GO:2000219
name: positive regulation of invasive growth in response to glucose limitation
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of invasive growth in response to glucose limitation." [GOC:mah]


id: GO:2000221
name: negative regulation of pseudohyphal growth
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of pseudohyphal growth." [GOC:mah]


id: GO:2000222
name: positive regulation of pseudohyphal growth
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of pseudohyphal growth." [GOC:mah]


id: GO:2000223
name: regulation of BMP signaling pathway involved in heart jogging
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of BMP signaling pathway involved in heart jogging." [GOC:BHF]


id: GO:2000224
name: regulation of testosterone biosynthetic process
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of testosterone biosynthetic process." [GOC:obol, GOC:yaf]


id: GO:2000225
name: negative regulation of testosterone biosynthetic process
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of testosterone biosynthetic process." [GOC:obol, GOC:yaf]


id: GO:2000226
name: regulation of pancreatic A cell differentiation
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of pancreatic A cell differentiation." [GOC:mah]


id: GO:2000227
name: negative regulation of pancreatic A cell differentiation
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of pancreatic A cell differentiation." [GOC:mah]


id: GO:2000228
name: positive regulation of pancreatic A cell differentiation
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of pancreatic A cell differentiation." [GOC:mah]


id: GO:2000229
name: regulation of pancreatic stellate cell proliferation
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of pancreatic stellate cell proliferation." [GOC:mah]


id: GO:2000230
name: negative regulation of pancreatic stellate cell proliferation
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of pancreatic stellate cell proliferation." [GOC:mah]


id: GO:2000231
name: positive regulation of pancreatic stellate cell proliferation
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of pancreatic stellate cell proliferation." [GOC:mah]


id: GO:2000233
name: negative regulation of rRNA processing
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of rRNA processing." [GOC:mah]


id: GO:2000234
name: positive regulation of rRNA processing
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of rRNA processing." [GOC:mah]


id: GO:2000236
name: negative regulation of tRNA processing
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of tRNA processing." [GOC:mah]


id: GO:2000237
name: positive regulation of tRNA processing
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of tRNA processing." [GOC:mah]


id: GO:2000239
name: negative regulation of tRNA export from nucleus
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of tRNA export from nucleus." [GOC:mah]


id: GO:2000240
name: positive regulation of tRNA export from nucleus
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of tRNA export from nucleus." [GOC:mah]


id: GO:2000242
name: negative regulation of reproductive process
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of reproductive process." [GOC:mah]


id: GO:2000243
name: positive regulation of reproductive process
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of reproductive process." [GOC:mah]


id: GO:2000245
name: negative regulation of FtsZ-dependent cytokinesis
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of Ftsz-dependent cytokinesis." [GOC:mah]


id: GO:2000246
name: positive regulation of FtsZ-dependent cytokinesis
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of Ftsz-dependent cytokinesis." [GOC:mah]


id: GO:2000247
name: positive regulation of establishment or maintenance of bipolar cell polarity regulating cell shape
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of establishment or maintenance of bipolar cell polarity regulating cell shape." [GOC:obol]


id: GO:2000248
name: negative regulation of establishment or maintenance of neuroblast polarity
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of establishment or maintenance of neuroblast polarity." [GOC:obol]


id: GO:2000249
name: regulation of actin cytoskeleton reorganization
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of actin cytoskeleton reorganization." [GOC:BHF]


id: GO:2000250
name: negative regulation of actin cytoskeleton reorganization
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of actin cytoskeleton reorganization." [GOC:BHF]


id: GO:2000251
name: positive regulation of actin cytoskeleton reorganization
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of actin cytoskeleton reorganization." [GOC:BHF]


id: GO:2000252
name: negative regulation of feeding behavior
namespace: biological_process
def:
  "Any process that stops, prevents or reduces the frequency, rate or extent of feeding behavior." [GOC:obol]


id: GO:2000253
name: positive regulation of feeding behavior
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of feeding behavior." [GOC:obol]


id: GO:2000254
name: regulation of male germ cell proliferation
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of male germ cell proliferation." [GOC:obol]


id: GO:2000255
name: negative regulation of male germ cell proliferation
namespace: biological_process
def:
  "Any process that stops, prevents or reduces the frequency, rate or extent of male germ cell proliferation." [GOC:obol]


id: GO:2000256
name: positive regulation of male germ cell proliferation
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of male germ cell proliferation." [GOC:obol]


id: GO:2000258
name: negative regulation of protein activation cascade
namespace: biological_process
def:
  "Any process that stops, prevents or reduces the frequency, rate or extent of protein activation cascade." [GOC:mah]


id: GO:2000259
name: positive regulation of protein activation cascade
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of protein activation cascade." [GOC:mah]


id: GO:2000260
name: regulation of blood coagulation, common pathway
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of blood coagulation, common pathway." [GOC:mah]


id: GO:2000261
name: negative regulation of blood coagulation, common pathway
namespace: biological_process
def:
  "Any process that stops, prevents or reduces the frequency, rate or extent of blood coagulation, common pathway." [GOC:mah]


id: GO:2000262
name: positive regulation of blood coagulation, common pathway
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of blood coagulation, common pathway." [GOC:mah]


id: GO:2000263
name: regulation of blood coagulation, extrinsic pathway
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of blood coagulation, extrinsic pathway." [GOC:mah]


id: GO:2000264
name: negative regulation of blood coagulation, extrinsic pathway
namespace: biological_process
def:
  "Any process that stops, prevents or reduces the frequency, rate or extent of blood coagulation, extrinsic pathway." [GOC:mah]


id: GO:2000265
name: positive regulation of blood coagulation, extrinsic pathway
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of blood coagulation, extrinsic pathway." [GOC:mah]


id: GO:2000266
name: regulation of blood coagulation, intrinsic pathway
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of blood coagulation, intrinsic pathway." [GOC:mah]


id: GO:2000267
name: negative regulation of blood coagulation, intrinsic pathway
namespace: biological_process
def:
  "Any process that stops, prevents or reduces the frequency, rate or extent of blood coagulation, intrinsic pathway." [GOC:mah]


id: GO:2000268
name: positive regulation of blood coagulation, intrinsic pathway
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of blood coagulation, intrinsic pathway." [GOC:mah]


id: GO:2000269
name: regulation of fibroblast apoptotic process
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of fibroblast apoptotic process." [GOC:mtg_apoptosis, GOC:obol, GOC:yaf]


id: GO:2000270
name: negative regulation of fibroblast apoptotic process
namespace: biological_process
def:
  "Any process that stops, prevents or reduces the frequency, rate or extent of fibroblast apoptotic process." [GOC:mtg_apoptosis, GOC:obol, GOC:yaf]


id: GO:2000271
name: positive regulation of fibroblast apoptotic process
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of fibroblast apoptotic process." [GOC:mtg_apoptosis, GOC:obol, GOC:yaf]


id: GO:2000272
name: negative regulation of receptor activity
namespace: biological_process
def:
  "Any process that stops, prevents or reduces the frequency, rate or extent of receptor activity." [GOC:obol]


id: GO:2000273
name: positive regulation of receptor activity
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of receptor activity." [GOC:obol]


id: GO:2000274
name: regulation of epithelial cell migration, open tracheal system
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of epithelial cell migration, open tracheal system." [GOC:obol]


id: GO:2000275
name: regulation of oxidative phosphorylation uncoupler activity
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of oxidative phosphorylation uncoupler activity." [GOC:mah]


id: GO:2000276
name: negative regulation of oxidative phosphorylation uncoupler activity
namespace: biological_process
def:
  "Any process that stops, prevents or reduces the frequency, rate or extent of oxidative phosphorylation uncoupler activity." [GOC:mah]


id: GO:2000277
name: positive regulation of oxidative phosphorylation uncoupler activity
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of oxidative phosphorylation uncoupler activity." [GOC:mah]


id: GO:2000279
name: negative regulation of DNA biosynthetic process
namespace: biological_process
def:
  "Any process that stops, prevents or reduces the frequency, rate or extent of DNA biosynthetic process." [GOC:obol]


id: GO:2000281
name: regulation of histone H3-T3 phosphorylation
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of histone H3-T3 phosphorylation." [GOC:obol]


id: GO:2000282
name: regulation of cellular amino acid biosynthetic process
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of cellular amino acid biosynthetic process." [GOC:obol]


id: GO:2000283
name: negative regulation of cellular amino acid biosynthetic process
namespace: biological_process
def:
  "Any process that stops, prevents or reduces the frequency, rate or extent of cellular amino acid biosynthetic process." [GOC:obol]


id: GO:2000284
name: positive regulation of cellular amino acid biosynthetic process
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of cellular amino acid biosynthetic process." [GOC:obol]


id: GO:2000285
name: obsolete negative regulation of regulation of excitatory postsynaptic membrane potential
namespace: biological_process
def:
  "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of regulation of excitatory postsynaptic membrane potential." [GOC:BHF]


id: GO:2000286
name: receptor internalization involved in canonical Wnt signaling pathway
namespace: biological_process
def:
  "A receptor internalization process that contributes to canonical Wnt signaling pathway." [GOC:BHF, GOC:mah, PMID:16890161]


id: GO:2000287
name: positive regulation of myotome development
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of myotome development." [GOC:BHF]


id: GO:2000288
name: positive regulation of myoblast proliferation
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of myoblast proliferation." [GOC:BHF]


id: GO:2000289
name: regulation of photoreceptor cell axon guidance
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of photoreceptor cell axon guidance." [GOC:mah]


id: GO:2000293
name: negative regulation of defecation
namespace: biological_process
def:
  "Any process that stops, prevents or reduces the frequency, rate or extent of defecation." [GOC:obol]


id: GO:2000295
name: regulation of hydrogen peroxide catabolic process
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of hydrogen peroxide catabolic process." [GOC:BHF]


id: GO:2000296
name: negative regulation of hydrogen peroxide catabolic process
namespace: biological_process
def:
  "Any process that stops, prevents or reduces the frequency, rate or extent of hydrogen peroxide catabolic process." [GOC:BHF]


id: GO:2000297
name: negative regulation of synapse maturation
namespace: biological_process
def:
  "Any process that stops, prevents or reduces the frequency, rate or extent of synapse maturation." [GOC:mah]


id: GO:2000298
name: regulation of Rho-dependent protein serine/threonine kinase activity
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of Rho-dependent protein serine/threonine kinase activity." [GOC:mah]


id: GO:2000299
name: negative regulation of Rho-dependent protein serine/threonine kinase activity
namespace: biological_process
def:
  "Any process that stops, prevents or reduces the frequency, rate or extent of Rho-dependent protein serine/threonine kinase activity." [GOC:mah]


id: GO:2000300
name: regulation of synaptic vesicle exocytosis
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of synaptic vesicle exocytosis." [GOC:obol]


id: GO:2000301
name: negative regulation of synaptic vesicle exocytosis
namespace: biological_process
def:
  "Any process that stops, prevents or reduces the frequency, rate or extent of synaptic vesicle exocytosis." [GOC:obol]


id: GO:2000302
name: positive regulation of synaptic vesicle exocytosis
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of synaptic vesicle exocytosis." [GOC:obol]


id: GO:2000303
name: regulation of ceramide biosynthetic process
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of a ceramide biosynthetic process." [GOC:dph]


id: GO:2000304
name: positive regulation of ceramide biosynthetic process
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of ceramide biosynthetic process." [GOC:dph]


id: GO:2000305
name: semaphorin-plexin signaling pathway involved in regulation of photoreceptor cell axon guidance
namespace: biological_process
def:
  "Any semaphorin-plexin signaling pathway that is involved in regulation of photoreceptor cell axon guidance." [GOC:obol]


id: GO:2000306
name: positive regulation of photomorphogenesis
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of photomorphogenesis." [GOC:obol]


id: GO:2000307
name: regulation of tumor necrosis factor (ligand) superfamily member 11 production
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of tumor necrosis factor (ligand) superfamily member 11 production." [GOC:BHF, GOC:mah]


id: GO:2000308
name: negative regulation of tumor necrosis factor (ligand) superfamily member 11 production
namespace: biological_process
def:
  "Any process that stops, prevents or reduces the frequency, rate or extent of tumor necrosis factor (ligand) superfamily member 11 production." [GOC:BHF, GOC:mah]


id: GO:2000309
name: positive regulation of tumor necrosis factor (ligand) superfamily member 11 production
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of tumor necrosis factor (ligand) superfamily member 11 production." [GOC:BHF, GOC:mah]


id: GO:2000310
name: regulation of N-methyl-D-aspartate selective glutamate receptor activity
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of N-methyl-D-aspartate selective glutamate receptor activity." [GOC:BHF]


id: GO:2000311
namespace: biological_process
name:
  regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity

def:
  "Any process that modulates the frequency, rate or extent of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity." [GOC:BHF]


id: GO:2000312
name: regulation of kainate selective glutamate receptor activity
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of kainate selective glutamate receptor activity." [GOC:BHF]


id: GO:2000313
namespace: biological_process
name:
  regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation

def:
  "Any process that modulates the frequency, rate or extent of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation." [GOC:BHF]


id: GO:2000314
namespace: biological_process
name:
  negative regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation

def:
  "Any process that stops, prevents or reduces the frequency, rate or extent of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation." [GOC:BHF]


id: GO:2000315
namespace: biological_process
name:
  positive regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation

def:
  "Any process that activates or increases the frequency, rate or extent of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation." [GOC:BHF]


id: GO:2000316
name: regulation of T-helper 17 type immune response
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of T-helper 17 type immune response." [GOC:BHF, GOC:mah]


id: GO:2000317
name: negative regulation of T-helper 17 type immune response
namespace: biological_process
def:
  "Any process that stops, prevents or reduces the frequency, rate or extent of T-helper 17 type immune response." [GOC:BHF, GOC:mah]


id: GO:2000318
name: positive regulation of T-helper 17 type immune response
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of T-helper 17 type immune response." [GOC:BHF, GOC:mah]


id: GO:2000319
name: regulation of T-helper 17 cell differentiation
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of T-helper 17 cell differentiation." [GOC:BHF, GOC:mah]


id: GO:2000320
name: negative regulation of T-helper 17 cell differentiation
namespace: biological_process
def:
  "Any process that stops, prevents or reduces the frequency, rate or extent of T-helper 17 cell differentiation." [GOC:BHF, GOC:mah]


id: GO:2000321
name: positive regulation of T-helper 17 cell differentiation
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of T-helper 17 cell differentiation." [GOC:BHF, GOC:mah]


id: GO:2000322
name: regulation of glucocorticoid receptor signaling pathway
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of glucocorticoid receptor signaling pathway." [GOC:BHF]


id: GO:2000323
name: negative regulation of glucocorticoid receptor signaling pathway
namespace: biological_process
def:
  "Any process that stops, prevents or reduces the frequency, rate or extent of glucocorticoid receptor signaling pathway." [GOC:BHF]


id: GO:2000324
name: positive regulation of glucocorticoid receptor signaling pathway
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of glucocorticoid receptor signaling pathway." [GOC:BHF]


id: GO:2000325
name: regulation of ligand-dependent nuclear receptor transcription coactivator activity
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of ligand-dependent nuclear receptor transcription coactivator activity." [GOC:BHF]


id: GO:2000326
name: negative regulation of ligand-dependent nuclear receptor transcription coactivator activity
namespace: biological_process
def:
  "Any process that stops, prevents or reduces the frequency, rate or extent of ligand-dependent nuclear receptor transcription coactivator activity." [GOC:BHF]


id: GO:2000327
name: positive regulation of ligand-dependent nuclear receptor transcription coactivator activity
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of ligand-dependent nuclear receptor transcription coactivator activity." [GOC:BHF]


id: GO:2000328
name: regulation of T-helper 17 cell lineage commitment
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of T-helper 17 cell lineage commitment." [GOC:BHF, GOC:mah]


id: GO:2000329
name: negative regulation of T-helper 17 cell lineage commitment
namespace: biological_process
def:
  "Any process that stops, prevents or reduces the frequency, rate or extent of T-helper 17 cell lineage commitment." [GOC:BHF, GOC:mah]


id: GO:2000330
name: positive regulation of T-helper 17 cell lineage commitment
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of T-helper 17 cell lineage commitment." [GOC:BHF, GOC:mah]


id: GO:2000331
name: regulation of terminal button organization
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of terminal button organization." [GOC:BHF, GOC:mah]


id: GO:2000332
name: regulation of blood microparticle formation
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of blood microparticle formation." [GOC:BHF, GOC:mah]


id: GO:2000333
name: negative regulation of blood microparticle formation
namespace: biological_process
def:
  "Any process that stops, prevents or reduces the frequency, rate or extent of blood microparticle formation." [GOC:BHF, GOC:mah]


id: GO:2000334
name: positive regulation of blood microparticle formation
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of blood microparticle formation." [GOC:BHF, GOC:mah]


id: GO:2000335
name: regulation of endothelial microparticle formation
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of endothelial microparticle formation." [GOC:BHF, GOC:mah]


id: GO:2000336
name: negative regulation of endothelial microparticle formation
namespace: biological_process
def:
  "Any process that stops, prevents or reduces the frequency, rate or extent of endothelial microparticle formation." [GOC:BHF, GOC:mah]


id: GO:2000337
name: positive regulation of endothelial microparticle formation
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of endothelial microparticle formation." [GOC:BHF, GOC:mah]


id: GO:2000338
name: regulation of chemokine (C-X-C motif) ligand 1 production
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of chemokine (C-X-C motif) ligand 1 production." [GOC:BHF, GOC:mah]


id: GO:2000339
name: negative regulation of chemokine (C-X-C motif) ligand 1 production
namespace: biological_process
def:
  "Any process that stops, prevents or reduces the frequency, rate or extent of chemokine (C-X-C motif) ligand 1 production." [GOC:BHF, GOC:mah]


id: GO:2000340
name: positive regulation of chemokine (C-X-C motif) ligand 1 production
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of chemokine (C-X-C motif) ligand 1 production." [GOC:BHF, GOC:mah]


id: GO:2000341
name: regulation of chemokine (C-X-C motif) ligand 2 production
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of chemokine (C-X-C motif) ligand 2 production." [GOC:BHF, GOC:mah]


id: GO:2000342
name: negative regulation of chemokine (C-X-C motif) ligand 2 production
namespace: biological_process
def:
  "Any process that stops, prevents or reduces the frequency, rate or extent of chemokine (C-X-C motif) ligand 2 production." [GOC:BHF, GOC:mah]


id: GO:2000343
name: positive regulation of chemokine (C-X-C motif) ligand 2 production
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of chemokine (C-X-C motif) ligand 2 production." [GOC:BHF, GOC:mah]


id: GO:2000344
name: positive regulation of acrosome reaction
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of the acrosome reaction." [GOC:obol]


id: GO:2000345
name: regulation of hepatocyte proliferation
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of hepatocyte proliferation." [GOC:BHF, GOC:mah]


id: GO:2000346
name: negative regulation of hepatocyte proliferation
namespace: biological_process
def:
  "Any process that stops, prevents or reduces the frequency, rate or extent of hepatocyte proliferation." [GOC:BHF, GOC:mah]


id: GO:2000347
name: positive regulation of hepatocyte proliferation
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of hepatocyte proliferation." [GOC:BHF, GOC:mah]


id: GO:2000348
name: regulation of CD40 signaling pathway
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of signaling via the CD40 signaling pathway." [GOC:mah]


id: GO:2000349
name: negative regulation of CD40 signaling pathway
namespace: biological_process
def:
  "Any process that stops, prevents or reduces the frequency, rate or extent of signaling via the CD40 signaling pathway." [GOC:BHF, GOC:mah]


id: GO:2000350
name: positive regulation of CD40 signaling pathway
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of signaling via the CD40 signaling pathway." [GOC:BHF, GOC:mah]


id: GO:2000351
name: regulation of endothelial cell apoptotic process
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of endothelial cell apoptotic process." [GOC:mah, GOC:mtg_apoptosis]


id: GO:2000352
name: negative regulation of endothelial cell apoptotic process
namespace: biological_process
def:
  "Any process that stops, prevents or reduces the frequency, rate or extent of endothelial cell apoptotic process." [GOC:BHF, GOC:mah, GOC:mtg_apoptosis]


id: GO:2000353
name: positive regulation of endothelial cell apoptotic process
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of endothelial cell apoptotic process." [GOC:BHF, GOC:mah, GOC:mtg_apoptosis]


id: GO:2000354
name: regulation of ovarian follicle development
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of ovarian follicle development." [GOC:obol]


id: GO:2000355
name: negative regulation of ovarian follicle development
namespace: biological_process
def:
  "Any process that stops, prevents or reduces the frequency, rate or extent of ovarian follicle development." [GOC:obol]


id: GO:2000356
name: regulation of kidney smooth muscle cell differentiation
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of kidney smooth muscle cell differentiation." [GOC:obol]


id: GO:2000357
name: negative regulation of kidney smooth muscle cell differentiation
namespace: biological_process
def:
  "Any process that stops, prevents or reduces the frequency, rate or extent of kidney smooth muscle cell differentiation." [GOC:obol]


id: GO:2000358
name: positive regulation of kidney smooth muscle cell differentiation
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of kidney smooth muscle cell differentiation." [GOC:obol]


id: GO:2000359
name: regulation of binding of sperm to zona pellucida
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of binding of sperm to the zona pellucida." [GOC:obol]


id: GO:2000360
name: negative regulation of binding of sperm to zona pellucida
namespace: biological_process
def:
  "Any process that stops, prevents or reduces the frequency, rate or extent of binding of sperm to the zona pellucida." [GOC:obol]


id: GO:2000361
name: regulation of prostaglandin-E synthase activity
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of prostaglandin-E synthase activity." [GOC:BHF]


id: GO:2000362
name: negative regulation of prostaglandin-E synthase activity
namespace: biological_process
def:
  "Any process that stops, prevents or reduces the frequency, rate or extent of prostaglandin-E synthase activity." [GOC:BHF]


id: GO:2000363
name: positive regulation of prostaglandin-E synthase activity
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of prostaglandin-E synthase activity." [GOC:BHF]


id: GO:2000364
name: regulation of STAT protein import into nucleus
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of STAT protein import into nucleus." [GOC:BHF]


id: GO:2000365
name: negative regulation of STAT protein import into nucleus
namespace: biological_process
def:
  "Any process that stops, prevents or reduces the frequency, rate or extent of STAT protein import into nucleus." [GOC:BHF]


id: GO:2000366
name: positive regulation of STAT protein import into nucleus
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of STAT protein import into nucleus." [GOC:BHF]


id: GO:2000367
name: regulation of acrosomal vesicle exocytosis
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of acrosomal vesicle exocytosis." [GOC:obol]


id: GO:2000368
name: positive regulation of acrosomal vesicle exocytosis
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of acrosomal vesicle exocytosis." [GOC:obol]


id: GO:2000369
name: regulation of clathrin-mediated endocytosis
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of clathrin-mediated endocytosis." [GOC:mah]


id: GO:2000370
name: positive regulation of clathrin-mediated endocytosis
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of clathrin-mediated endocytosis." [GOC:BHF, GOC:mah]


id: GO:2000371
name: regulation of DNA topoisomerase (ATP-hydrolyzing) activity
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of DNA topoisomerase (ATP-hydrolyzing) activity." [GOC:mah]


id: GO:2000372
name: negative regulation of DNA topoisomerase (ATP-hydrolyzing) activity
namespace: biological_process
def:
  "Any process that stops, prevents or reduces the frequency, rate or extent of DNA topoisomerase (ATP-hydrolyzing) activity." [GOC:mah]


id: GO:2000373
name: positive regulation of DNA topoisomerase (ATP-hydrolyzing) activity
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of DNA topoisomerase (ATP-hydrolyzing) activity." [GOC:mah]


id: GO:2000375
name: negative regulation of oxygen metabolic process
namespace: biological_process
def:
  "Any process that stops, prevents or reduces the frequency, rate or extent of oxygen metabolic process." [GOC:mah]


id: GO:2000376
name: positive regulation of oxygen metabolic process
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of oxygen metabolic process." [GOC:mah]


id: GO:2000377
name: regulation of reactive oxygen species metabolic process
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of reactive oxygen species metabolic process." [GOC:mah]


id: GO:2000378
name: negative regulation of reactive oxygen species metabolic process
namespace: biological_process
def:
  "Any process that stops, prevents or reduces the frequency, rate or extent of reactive oxygen species metabolic process." [GOC:mah]


id: GO:2000379
name: positive regulation of reactive oxygen species metabolic process
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of reactive oxygen species metabolic process." [GOC:mah]


id: GO:2000381
name: negative regulation of mesoderm development
namespace: biological_process
def:
  "Any process that stops, prevents or reduces the frequency, rate or extent of mesoderm development." [GOC:BHF]


id: GO:2000382
name: positive regulation of mesoderm development
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of mesoderm development." [GOC:BHF]


id: GO:2000384
name: negative regulation of ectoderm development
namespace: biological_process
def:
  "Any process that stops, prevents or reduces the frequency, rate or extent of ectoderm development." [GOC:BHF]


id: GO:2000385
name: positive regulation of ectoderm development
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of ectoderm development." [GOC:BHF]


id: GO:2000386
name: positive regulation of ovarian follicle development
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of ovarian follicle development." [GOC:obol]


id: GO:2000387
name: regulation of antral ovarian follicle growth
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of antral ovarian follicle growth." [GOC:obol]


id: GO:2000388
name: positive regulation of antral ovarian follicle growth
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of antral ovarian follicle growth." [GOC:obol]


id: GO:2000390
name: negative regulation of neutrophil extravasation
namespace: biological_process
def:
  "Any process that stops, prevents or reduces the frequency, rate or extent of neutrophil extravasation." [GOC:BHF, GOC:mah]


id: GO:2000391
name: positive regulation of neutrophil extravasation
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of neutrophil extravasation." [GOC:BHF, GOC:mah]


id: GO:2000392
name: regulation of lamellipodium morphogenesis
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of lamellipodium morphogenesis." [GOC:mah]


id: GO:2000393
name: negative regulation of lamellipodium morphogenesis
namespace: biological_process
def:
  "Any process that stops, prevents or reduces the frequency, rate or extent of lamellipodium morphogenesis." [GOC:BHF, GOC:mah]


id: GO:2000394
name: positive regulation of lamellipodium morphogenesis
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of lamellipodium morphogenesis." [GOC:BHF, GOC:mah]


id: GO:2000395
name: regulation of ubiquitin-dependent endocytosis
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of ubiquitin-dependent endocytosis." [GOC:mah]


id: GO:2000396
name: negative regulation of ubiquitin-dependent endocytosis
namespace: biological_process
def:
  "Any process that stops, prevents or reduces the frequency, rate or extent of ubiquitin-dependent endocytosis." [GOC:mah]


id: GO:2000397
name: positive regulation of ubiquitin-dependent endocytosis
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of ubiquitin-dependent endocytosis." [GOC:mah]


id: GO:2000399
name: negative regulation of thymocyte aggregation
namespace: biological_process
def:
  "Any process that stops, prevents or reduces the frequency, rate or extent of thymocyte aggregation." [GOC:BHF, GOC:mah]


id: GO:2000400
name: positive regulation of thymocyte aggregation
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of thymocyte aggregation." [GOC:BHF, GOC:mah]


id: GO:2000402
name: negative regulation of lymphocyte migration
namespace: biological_process
def:
  "Any process that stops, prevents or reduces the frequency, rate or extent of lymphocyte migration." [GOC:mah]


id: GO:2000403
name: positive regulation of lymphocyte migration
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of lymphocyte migration." [GOC:mah]


id: GO:2000405
name: negative regulation of T cell migration
namespace: biological_process
def:
  "Any process that stops, prevents or reduces the frequency, rate or extent of T cell migration." [GOC:mah]


id: GO:2000406
name: positive regulation of T cell migration
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of T cell migration." [GOC:mah]


id: GO:2000408
name: negative regulation of T cell extravasation
namespace: biological_process
def:
  "Any process that stops, prevents or reduces the frequency, rate or extent of T cell extravasation." [GOC:BHF, GOC:mah]


id: GO:2000409
name: positive regulation of T cell extravasation
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of T cell extravasation." [GOC:BHF, GOC:mah]


id: GO:2000411
name: negative regulation of thymocyte migration
namespace: biological_process
def:
  "Any process that stops, prevents or reduces the frequency, rate or extent of thymocyte migration." [GOC:mah]


id: GO:2000412
name: positive regulation of thymocyte migration
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of thymocyte migration." [GOC:mah]


id: GO:2000413
name: regulation of fibronectin-dependent thymocyte migration
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of fibronectin-dependent thymocyte migration." [GOC:mah]


id: GO:2000414
name: negative regulation of fibronectin-dependent thymocyte migration
namespace: biological_process
def:
  "Any process that stops, prevents or reduces the frequency, rate or extent of fibronectin-dependent thymocyte migration." [GOC:BHF, GOC:mah]


id: GO:2000415
name: positive regulation of fibronectin-dependent thymocyte migration
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of fibronectin-dependent thymocyte migration." [GOC:BHF, GOC:mah]


id: GO:2000417
name: negative regulation of eosinophil migration
namespace: biological_process
def:
  "Any process that stops, prevents or reduces the frequency, rate or extent of eosinophil migration." [GOC:mah]


id: GO:2000418
name: positive regulation of eosinophil migration
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of eosinophil migration." [GOC:mah]


id: GO:2000420
name: negative regulation of eosinophil extravasation
namespace: biological_process
def:
  "Any process that stops, prevents or reduces the frequency, rate or extent of eosinophil extravasation." [GOC:BHF, GOC:mah]


id: GO:2000421
name: positive regulation of eosinophil extravasation
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of eosinophil extravasation." [GOC:BHF, GOC:mah]


id: GO:2000423
name: negative regulation of eosinophil chemotaxis
namespace: biological_process
def:
  "Any process that stops, prevents or reduces the frequency, rate or extent of eosinophil chemotaxis." [GOC:obol]


id: GO:2000424
name: positive regulation of eosinophil chemotaxis
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of eosinophil chemotaxis." [GOC:obol]


id: GO:2000426
name: negative regulation of apoptotic cell clearance
namespace: biological_process
def:
  "Any process that stops, prevents or reduces the frequency, rate or extent of apoptotic cell clearance." [GOC:obol]


id: GO:2000427
name: positive regulation of apoptotic cell clearance
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of apoptotic cell clearance." [GOC:obol]


id: GO:2000429
name: negative regulation of neutrophil aggregation
namespace: biological_process
def:
  "Any process that stops, prevents or reduces the frequency, rate or extent of neutrophil aggregation." [GOC:BHF]


id: GO:2000430
name: positive regulation of neutrophil aggregation
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of neutrophil aggregation." [GOC:BHF]


id: GO:2000431
name: regulation of cytokinesis, actomyosin contractile ring assembly
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of cytokinesis, actomyosin contractile ring assembly." [GOC:obol]


id: GO:2000432
name: negative regulation of cytokinesis, actomyosin contractile ring assembly
namespace: biological_process
def:
  "Any process that stops, prevents or reduces the frequency, rate or extent of cytokinesis, actomyosin contractile ring assembly." [GOC:obol]


id: GO:2000433
name: positive regulation of cytokinesis, actomyosin contractile ring assembly
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of cytokinesis, actomyosin contractile ring assembly." [GOC:obol]


id: GO:2000435
name: negative regulation of protein neddylation
namespace: biological_process
def:
  "Any process that stops, prevents or reduces the frequency, rate or extent of protein neddylation." [GOC:obol]


id: GO:2000436
name: positive regulation of protein neddylation
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of protein neddylation." [GOC:obol]


id: GO:2000438
name: negative regulation of monocyte extravasation
namespace: biological_process
def:
  "Any process that stops, prevents or reduces the frequency, rate or extent of monocyte extravasation." [GOC:obol]


id: GO:2000439
name: positive regulation of monocyte extravasation
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of monocyte extravasation." [GOC:obol]


id: GO:2000440
name: regulation of toll-like receptor 15 signaling pathway
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of toll-like receptor 15 signaling pathway." [GOC:obol]


id: GO:2000441
name: negative regulation of toll-like receptor 15 signaling pathway
namespace: biological_process
def:
  "Any process that stops, prevents or reduces the frequency, rate or extent of toll-like receptor 15 signaling pathway." [GOC:obol]


id: GO:2000442
name: positive regulation of toll-like receptor 15 signaling pathway
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of toll-like receptor 15 signaling pathway." [GOC:obol]


id: GO:2000443
name: regulation of toll-like receptor 21 signaling pathway
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of toll-like receptor 21 signaling pathway." [GOC:obol]


id: GO:2000444
name: negative regulation of toll-like receptor 21 signaling pathway
namespace: biological_process
def:
  "Any process that stops, prevents or reduces the frequency, rate or extent of toll-like receptor 21 signaling pathway." [GOC:obol]


id: GO:2000445
name: positive regulation of toll-like receptor 21 signaling pathway
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of toll-like receptor 21 signaling pathway." [GOC:obol]


id: GO:2000446
name: regulation of macrophage migration inhibitory factor signaling pathway
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of macrophage migration inhibitory factor signaling pathway." [GOC:obol]


id: GO:2000447
name: negative regulation of macrophage migration inhibitory factor signaling pathway
namespace: biological_process
def:
  "Any process that stops, prevents or reduces the frequency, rate or extent of macrophage migration inhibitory factor signaling pathway." [GOC:obol]


id: GO:2000448
name: positive regulation of macrophage migration inhibitory factor signaling pathway
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of macrophage migration inhibitory factor signaling pathway." [GOC:obol]


id: GO:2000449
name: regulation of CD8-positive, alpha-beta T cell extravasation
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of CD8-positive, alpha-beta T cell extravasation." [GOC:obol]


id: GO:2000450
name: negative regulation of CD8-positive, alpha-beta T cell extravasation
namespace: biological_process
def:
  "Any process that stops, prevents or reduces the frequency, rate or extent of CD8-positive, alpha-beta T cell extravasation." [GOC:obol]


id: GO:2000451
name: positive regulation of CD8-positive, alpha-beta T cell extravasation
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of CD8-positive, alpha-beta T cell extravasation." [GOC:obol]


id: GO:2000452
name: regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of CD8-positive, alpha-beta cytotoxic T cell extravasation." [GOC:obol]


id: GO:2000453
name: negative regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation
namespace: biological_process
def:
  "Any process that stops, prevents or reduces the frequency, rate or extent of CD8-positive, alpha-beta cytotoxic T cell extravasation." [GOC:obol]


id: GO:2000454
name: positive regulation of CD8-positive, alpha-beta cytotoxic T cell extravasation
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of CD8-positive, alpha-beta cytotoxic T cell extravasation." [GOC:obol]


id: GO:2000455
name: regulation of T-helper 17 cell extravasation
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of T-helper 17 cell extravasation." [GOC:obol]


id: GO:2000456
name: negative regulation of T-helper 17 cell extravasation
namespace: biological_process
def:
  "Any process that stops, prevents or reduces the frequency, rate or extent of T-helper 17 cell extravasation." [GOC:obol]


id: GO:2000457
name: positive regulation of T-helper 17 cell extravasation
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of T-helper 17 cell extravasation." [GOC:obol]


id: GO:2000459
name: negative regulation of astrocyte chemotaxis
namespace: biological_process
def:
  "Any process that stops, prevents or reduces the frequency, rate or extent of astrocyte chemotaxis." [GOC:obol]


id: GO:2000460
name: obsolete regulation of eukaryotic cell surface binding
namespace: biological_process
def:
  "OBSOLETE. Any process that modulates the frequency, rate or extent of eukaryotic cell surface binding." [GOC:obol]


id: GO:2000461
name: obsolete negative regulation of eukaryotic cell surface binding
namespace: biological_process
def:
  "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of eukaryotic cell surface binding." [GOC:obol]


id: GO:2000462
name: obsolete positive regulation of eukaryotic cell surface binding
namespace: biological_process
def:
  "OBSOLETE. Any process that activates or increases the frequency, rate or extent of eukaryotic cell surface binding." [GOC:obol]


id: GO:2000463
name: positive regulation of excitatory postsynaptic potential
namespace: biological_process
def:
  "Any process that enhances the establishment or increases the extent of the excitatory postsynaptic potential (EPSP) which is a temporary increase in postsynaptic potential due to the flow of positively charged ions into the postsynaptic cell. The flow of ions that causes an EPSP is an excitatory postsynaptic current (EPSC) and makes it easier for the neuron to fire an action potential." [GOC:bf, GOC:BHF]


id: GO:2000464
name: positive regulation of astrocyte chemotaxis
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of astrocyte chemotaxis." [GOC:obol]


id: GO:2000465
name: regulation of glycogen (starch) synthase activity
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of glycogen (starch) synthase activity." [GOC:obol]


id: GO:2000466
name: negative regulation of glycogen (starch) synthase activity
namespace: biological_process
def:
  "Any process that stops, prevents or reduces the frequency, rate or extent of glycogen (starch) synthase activity." [GOC:obol]


id: GO:2000467
name: positive regulation of glycogen (starch) synthase activity
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of glycogen (starch) synthase activity." [GOC:obol]


id: GO:2000469
name: negative regulation of peroxidase activity
namespace: biological_process
def:
  "Any process that stops, prevents or reduces the frequency, rate or extent of peroxidase activity." [GOC:obol]


id: GO:2000470
name: positive regulation of peroxidase activity
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of peroxidase activity." [GOC:obol]


id: GO:2000471
name: regulation of hematopoietic stem cell migration
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of hematopoietic stem cell migration." [GOC:obol]


id: GO:2000472
name: negative regulation of hematopoietic stem cell migration
namespace: biological_process
def:
  "Any process that stops, prevents or reduces the frequency, rate or extent of hematopoietic stem cell migration." [GOC:obol]


id: GO:2000473
name: positive regulation of hematopoietic stem cell migration
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of hematopoietic stem cell migration." [GOC:obol]


id: GO:2000474
name: regulation of opioid receptor signaling pathway
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of opioid receptor signaling pathway." [GOC:obol]


id: GO:2000475
name: negative regulation of opioid receptor signaling pathway
namespace: biological_process
def:
  "Any process that stops, prevents or reduces the frequency, rate or extent of opioid receptor signaling pathway." [GOC:obol]


id: GO:2000476
name: positive regulation of opioid receptor signaling pathway
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of opioid receptor signaling pathway." [GOC:obol]


id: GO:2000477
name: regulation of metanephric glomerular visceral epithelial cell development
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of metanephric glomerular visceral epithelial cell development." [GOC:obol]


id: GO:2000478
name: positive regulation of metanephric glomerular visceral epithelial cell development
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of metanephric glomerular visceral epithelial cell development." [GOC:obol]


id: GO:2000479
name: regulation of cAMP-dependent protein kinase activity
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of cAMP-dependent protein kinase activity." [GOC:obol]


id: GO:2000480
name: negative regulation of cAMP-dependent protein kinase activity
namespace: biological_process
def:
  "Any process that stops, prevents or reduces the frequency, rate or extent of cAMP-dependent protein kinase activity." [GOC:obol]


id: GO:2000481
name: positive regulation of cAMP-dependent protein kinase activity
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of cAMP-dependent protein kinase activity." [GOC:obol]


id: GO:2000483
name: negative regulation of interleukin-8 secretion
namespace: biological_process
def:
  "Any process that stops, prevents or reduces the frequency, rate or extent of interleukin-8 secretion." [GOC:obol]


id: GO:2000484
name: positive regulation of interleukin-8 secretion
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of interleukin-8 secretion." [GOC:obol]


id: GO:2000486
name: negative regulation of glutamine transport
namespace: biological_process
def:
  "Any process that stops, prevents or reduces the frequency, rate or extent of glutamine transport." [GOC:obol]


id: GO:2000487
name: positive regulation of glutamine transport
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of glutamine transport." [GOC:obol]


id: GO:2000488
name: positive regulation of brassinosteroid biosynthetic process
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of brassinosteroid biosynthetic process." [GOC:obol]


id: GO:2000489
name: regulation of hepatic stellate cell activation
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of hepatic stellate cell activation." [GOC:obol]


id: GO:2000490
name: negative regulation of hepatic stellate cell activation
namespace: biological_process
def:
  "Any process that stops, prevents or reduces the frequency, rate or extent of hepatic stellate cell activation." [GOC:obol]


id: GO:2000491
name: positive regulation of hepatic stellate cell activation
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of hepatic stellate cell activation." [GOC:obol]


id: GO:2000492
name: regulation of interleukin-18-mediated signaling pathway
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of interleukin-18-mediated signaling pathway." [GOC:obol]


id: GO:2000493
name: negative regulation of interleukin-18-mediated signaling pathway
namespace: biological_process
def:
  "Any process that stops, prevents or reduces the frequency, rate or extent of interleukin-18-mediated signaling pathway." [GOC:obol]


id: GO:2000494
name: positive regulation of interleukin-18-mediated signaling pathway
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of interleukin-18-mediated signaling pathway." [GOC:obol]


id: GO:2000495
name: regulation of cell proliferation involved in compound eye morphogenesis
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of cell proliferation involved in compound eye morphogenesis." [GOC:obol]


id: GO:2000496
name: negative regulation of cell proliferation involved in compound eye morphogenesis
namespace: biological_process
def:
  "Any process that stops, prevents or reduces the frequency, rate or extent of cell proliferation involved in compound eye morphogenesis." [GOC:obol]


id: GO:2000497
name: positive regulation of cell proliferation involved in compound eye morphogenesis
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of cell proliferation involved in compound eye morphogenesis." [GOC:obol]


id: GO:2000498
name: obsolete regulation of induction of apoptosis in response to chemical stimulus
namespace: biological_process
def:
  "OBSOLETE. Any process that modulates the frequency, rate or extent of induction of apoptosis in response to chemical stimulus." [GOC:mtg_apoptosis, GOC:obol]


id: GO:2000499
name: obsolete negative regulation of induction of apoptosis in response to chemical stimulus
namespace: biological_process
def:
  "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of induction of apoptosis in response to chemical stimulus." [GOC:mtg_apoptosis, GOC:obol]


id: GO:2000500
name: obsolete positive regulation of induction of apoptosis in response to chemical stimulus
namespace: biological_process
def:
  "OBSOLETE. Any process that activates or increases the frequency, rate or extent of induction of apoptosis in response to chemical stimulus." [GOC:mtg_apoptosis, GOC:obol]


id: GO:2000501
name: regulation of natural killer cell chemotaxis
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of natural killer cell chemotaxis." [GOC:BHF]


id: GO:2000502
name: negative regulation of natural killer cell chemotaxis
namespace: biological_process
def:
  "Any process that stops, prevents or reduces the frequency, rate or extent of natural killer cell chemotaxis." [GOC:BHF]


id: GO:2000503
name: positive regulation of natural killer cell chemotaxis
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of natural killer cell chemotaxis." [GOC:BHF]


id: GO:2000504
name: positive regulation of blood vessel remodeling
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of blood vessel remodeling." [GOC:obol]


id: GO:2000505
name: regulation of energy homeostasis
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of energy homeostasis." [GOC:obol, GOC:yaf]


id: GO:2000506
name: negative regulation of energy homeostasis
namespace: biological_process
def:
  "Any process that stops, prevents or reduces the frequency, rate or extent of energy homeostasis." [GOC:obol, GOC:yaf]


id: GO:2000507
name: positive regulation of energy homeostasis
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of energy homeostasis." [GOC:obol, GOC:yaf]


id: GO:2000509
name: negative regulation of dendritic cell chemotaxis
namespace: biological_process
def:
  "Any process that stops, prevents or reduces the frequency, rate or extent of dendritic cell chemotaxis." [GOC:obol]


id: GO:2000510
name: positive regulation of dendritic cell chemotaxis
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of dendritic cell chemotaxis." [GOC:obol]


id: GO:2000512
name: negative regulation of granzyme A production
namespace: biological_process
def:
  "Any process that stops, prevents or reduces the frequency, rate or extent of granzyme A production." [GOC:obol]


id: GO:2000513
name: positive regulation of granzyme A production
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of granzyme A production." [GOC:obol]


id: GO:2000514
name: regulation of CD4-positive, alpha-beta T cell activation
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of CD4-positive, alpha-beta T cell activation." [GOC:obol]


id: GO:2000515
name: negative regulation of CD4-positive, alpha-beta T cell activation
namespace: biological_process
def:
  "Any process that stops, prevents or reduces the frequency, rate or extent of CD4-positive, alpha-beta T cell activation." [GOC:obol]


id: GO:2000516
name: positive regulation of CD4-positive, alpha-beta T cell activation
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of CD4-positive, alpha-beta T cell activation." [GOC:obol]


id: GO:2000517
name: regulation of T-helper 1 cell activation
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of T-helper 1 cell activation." [GOC:obol]


id: GO:2000518
name: negative regulation of T-helper 1 cell activation
namespace: biological_process
def:
  "Any process that stops, prevents or reduces the frequency, rate or extent of T-helper 1 cell activation." [GOC:obol]


id: GO:2000519
name: positive regulation of T-helper 1 cell activation
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of T-helper 1 cell activation." [GOC:obol]


id: GO:2000520
name: regulation of immunological synapse formation
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of immunological synapse formation." [GOC:obol]


id: GO:2000521
name: negative regulation of immunological synapse formation
namespace: biological_process
def:
  "Any process that stops, prevents or reduces the frequency, rate or extent of immunological synapse formation." [GOC:obol]


id: GO:2000522
name: positive regulation of immunological synapse formation
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of immunological synapse formation." [GOC:obol]


id: GO:2000524
name: negative regulation of T cell costimulation
namespace: biological_process
def:
  "Any process that stops, prevents or reduces the frequency, rate or extent of T cell costimulation." [GOC:obol]


id: GO:2000525
name: positive regulation of T cell costimulation
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of T cell costimulation." [GOC:obol]


id: GO:2000526
namespace: biological_process
name:
  positive regulation of glycoprotein biosynthetic process involved in immunological synapse formation

def:
  "Any positive regulation of glycoprotein biosynthetic process that is involved in immunological synapse formation." [GOC:obol]


id: GO:2000527
name: regulation of myeloid dendritic cell chemotaxis
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of myeloid dendritic cell chemotaxis." [GOC:obol]


id: GO:2000528
name: negative regulation of myeloid dendritic cell chemotaxis
namespace: biological_process
def:
  "Any process that stops, prevents or reduces the frequency, rate or extent of myeloid dendritic cell chemotaxis." [GOC:obol]


id: GO:2000529
name: positive regulation of myeloid dendritic cell chemotaxis
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of myeloid dendritic cell chemotaxis." [GOC:obol]


id: GO:2000530
namespace: biological_process
name:
  obsolete positive regulation of regulation of insulin secretion involved in cellular response to glucose stimulus

def:
  "Any process that activates or increases the frequency, rate or extent of regulation of insulin secretion involved in cellular response to glucose stimulus." [GOC:obol]


id: GO:2000531
namespace: biological_process
name:
  regulation of fatty acid biosynthetic process by regulation of transcription from RNA polymerase II promoter

def:
  "Any process that modulates the frequency, rate or extent of the biosynthesis of fatty acids, by modulating the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:vw]


id: GO:2000532
name: regulation of renal albumin absorption
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of renal albumin absorption." [GOC:obol, GOC:yaf]


id: GO:2000533
name: negative regulation of renal albumin absorption
namespace: biological_process
def:
  "Any process that stops, prevents or reduces the frequency, rate or extent of renal albumin absorption." [GOC:obol, GOC:yaf]


id: GO:2000534
name: positive regulation of renal albumin absorption
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of renal albumin absorption." [GOC:obol, GOC:yaf]


id: GO:2000535
name: regulation of entry of bacterium into host cell
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of entry of bacterium into host cell." [GOC:obol]


id: GO:2000536
name: negative regulation of entry of bacterium into host cell
namespace: biological_process
def:
  "Any process that stops, prevents or reduces the frequency, rate or extent of entry of bacterium into host cell." [GOC:obol]


id: GO:2000538
name: positive regulation of B cell chemotaxis
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of B cell chemotaxis." [GOC:obol]


id: GO:2000539
name: regulation of protein geranylgeranylation
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of protein geranylgeranylation." [GOC:obol]


id: GO:2000540
name: negative regulation of protein geranylgeranylation
namespace: biological_process
def:
  "Any process that stops, prevents or reduces the frequency, rate or extent of protein geranylgeranylation." [GOC:obol]


id: GO:2000541
name: positive regulation of protein geranylgeranylation
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of protein geranylgeranylation." [GOC:obol]


id: GO:2000542
name: negative regulation of gastrulation
namespace: biological_process
def:
  "Any process that stops, prevents or reduces the frequency, rate or extent of gastrulation." [GOC:obol]


id: GO:2000544
name: regulation of endothelial cell chemotaxis to fibroblast growth factor
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of endothelial cell chemotaxis to fibroblast growth factor." [GOC:obol]


id: GO:2000545
name: negative regulation of endothelial cell chemotaxis to fibroblast growth factor
namespace: biological_process
def:
  "Any process that stops, prevents or reduces the frequency, rate or extent of endothelial cell chemotaxis to fibroblast growth factor." [GOC:obol]


id: GO:2000546
name: positive regulation of endothelial cell chemotaxis to fibroblast growth factor
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of endothelial cell chemotaxis to fibroblast growth factor." [GOC:obol]


id: GO:2000547
name: regulation of dendritic cell dendrite assembly
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of dendritic cell dendrite assembly." [GOC:obol]


id: GO:2000548
name: negative regulation of dendritic cell dendrite assembly
namespace: biological_process
def:
  "Any process that stops, prevents or reduces the frequency, rate or extent of dendritic cell dendrite assembly." [GOC:obol]


id: GO:2000549
name: positive regulation of dendritic cell dendrite assembly
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of dendritic cell dendrite assembly." [GOC:obol]


id: GO:2000550
name: negative regulation of B cell chemotaxis
namespace: biological_process
def:
  "Any process that stops, prevents or reduces the frequency, rate or extent of B cell chemotaxis." [GOC:obol]


id: GO:2000551
name: regulation of T-helper 2 cell cytokine production
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of T-helper 2 cell cytokine production." [GOC:obol]


id: GO:2000552
name: negative regulation of T-helper 2 cell cytokine production
namespace: biological_process
def:
  "Any process that stops, prevents or reduces the frequency, rate or extent of T-helper 2 cell cytokine production." [GOC:obol]


id: GO:2000553
name: positive regulation of T-helper 2 cell cytokine production
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of T-helper 2 cell cytokine production." [GOC:obol]


id: GO:2000554
name: regulation of T-helper 1 cell cytokine production
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of T-helper 1 cell cytokine production." [GOC:obol]


id: GO:2000555
name: negative regulation of T-helper 1 cell cytokine production
namespace: biological_process
def:
  "Any process that stops, prevents or reduces the frequency, rate or extent of T-helper 1 cell cytokine production." [GOC:obol]


id: GO:2000556
name: positive regulation of T-helper 1 cell cytokine production
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of T-helper 1 cell cytokine production." [GOC:obol]


id: GO:2000557
name: regulation of immunoglobulin production in mucosal tissue
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of immunoglobulin production in mucosal tissue." [GOC:obol]


id: GO:2000558
name: positive regulation of immunoglobulin production in mucosal tissue
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of immunoglobulin production in mucosal tissue." [GOC:obol]


id: GO:2000560
name: positive regulation of CD24 biosynthetic process
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of CD24 biosynthetic process." [GOC:obol]


id: GO:2000561
name: regulation of CD4-positive, alpha-beta T cell proliferation
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of CD4-positive, alpha-beta T cell proliferation." [GOC:obol]


id: GO:2000562
name: negative regulation of CD4-positive, alpha-beta T cell proliferation
namespace: biological_process
def:
  "Any process that stops, prevents or reduces the frequency, rate or extent of CD4-positive, alpha-beta T cell proliferation." [GOC:obol]


id: GO:2000563
name: positive regulation of CD4-positive, alpha-beta T cell proliferation
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of CD4-positive, alpha-beta T cell proliferation." [GOC:obol]


id: GO:2000564
name: regulation of CD8-positive, alpha-beta T cell proliferation
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of CD8-positive, alpha-beta T cell proliferation." [GOC:obol]


id: GO:2000565
name: negative regulation of CD8-positive, alpha-beta T cell proliferation
namespace: biological_process
def:
  "Any process that stops, prevents or reduces the frequency, rate or extent of CD8-positive, alpha-beta T cell proliferation." [GOC:obol]


id: GO:2000566
name: positive regulation of CD8-positive, alpha-beta T cell proliferation
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of CD8-positive, alpha-beta T cell proliferation." [GOC:obol]


id: GO:2000568
name: positive regulation of memory T cell activation
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of memory T cell activation." [GOC:obol]


id: GO:2000569
name: regulation of T-helper 2 cell activation
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of T-helper 2 cell activation." [GOC:obol]


id: GO:2000570
name: positive regulation of T-helper 2 cell activation
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of T-helper 2 cell activation." [GOC:obol]


id: GO:2000571
name: regulation of interleukin-4-dependent isotype switching to IgE isotypes
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of interleukin-4-dependent isotype switching to IgE isotypes." [GOC:obol]


id: GO:2000572
name: positive regulation of interleukin-4-dependent isotype switching to IgE isotypes
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of interleukin-4-dependent isotype switching to IgE isotypes." [GOC:obol]


id: GO:2000573
name: positive regulation of DNA biosynthetic process
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of DNA biosynthetic process." [GOC:obol]


id: GO:2000575
name: negative regulation of microtubule motor activity
namespace: biological_process
def:
  "Any process that stops, prevents or reduces the frequency, rate or extent of microtubule motor activity." [GOC:kmv]


id: GO:2000576
name: positive regulation of microtubule motor activity
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of microtubule motor activity." [GOC:kmv]


id: GO:2000577
name: regulation of ATP-dependent microtubule motor activity, minus-end-directed
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of ATP-dependent microtubule motor activity, minus-end-directed." [GOC:kmv, GOC:vw]


id: GO:2000578
name: negative regulation of ATP-dependent microtubule motor activity, minus-end-directed
namespace: biological_process
def:
  "Any process that stops, prevents or reduces the frequency, rate or extent of ATP-dependent microtubule motor activity, minus-end-directed." [GOC:kmv, GOC:vw]


id: GO:2000579
name: positive regulation of ATP-dependent microtubule motor activity, minus-end-directed
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of ATP-dependent microtubule motor activity, minus-end-directed." [GOC:kmv, GOC:vw]


id: GO:2000580
name: regulation of ATP-dependent microtubule motor activity, plus-end-directed
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of ATP-dependent microtubule motor activity, plus-end-directed." [GOC:kmv, GOC:vw]


id: GO:2000581
name: negative regulation of ATP-dependent microtubule motor activity, plus-end-directed
namespace: biological_process
def:
  "Any process that stops, prevents or reduces the frequency, rate or extent of ATP-dependent microtubule motor activity, plus-end-directed." [GOC:kmv, GOC:vw]


id: GO:2000582
name: positive regulation of ATP-dependent microtubule motor activity, plus-end-directed
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of ATP-dependent microtubule motor activity, plus-end-directed." [GOC:kmv, GOC:vw]


id: GO:2000583
name: regulation of platelet-derived growth factor receptor-alpha signaling pathway
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of platelet-derived growth factor receptor-alpha signaling pathway." [GOC:obol]


id: GO:2000584
name: negative regulation of platelet-derived growth factor receptor-alpha signaling pathway
namespace: biological_process
def:
  "Any process that stops, prevents or reduces the frequency, rate or extent of platelet-derived growth factor receptor-alpha signaling pathway." [GOC:obol, GOC:yaf]


id: GO:2000585
name: positive regulation of platelet-derived growth factor receptor-alpha signaling pathway
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of platelet-derived growth factor receptor-alpha signaling pathway." [GOC:obol]


id: GO:2000586
name: regulation of platelet-derived growth factor receptor-beta signaling pathway
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of platelet-derived growth factor receptor-beta signaling pathway." [GOC:obol]


id: GO:2000587
name: negative regulation of platelet-derived growth factor receptor-beta signaling pathway
namespace: biological_process
def:
  "Any process that stops, prevents or reduces the frequency, rate or extent of platelet-derived growth factor receptor-beta signaling pathway." [GOC:obol]


id: GO:2000588
name: positive regulation of platelet-derived growth factor receptor-beta signaling pathway
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of platelet-derived growth factor receptor-beta signaling pathway." [GOC:obol]


id: GO:2000589
name: regulation of metanephric mesenchymal cell migration
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of metanephric mesenchymal cell migration." [GOC:obol]


id: GO:2000590
name: negative regulation of metanephric mesenchymal cell migration
namespace: biological_process
def:
  "Any process that stops, prevents or reduces the frequency, rate or extent of metanephric mesenchymal cell migration." [GOC:obol]


id: GO:2000591
name: positive regulation of metanephric mesenchymal cell migration
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of metanephric mesenchymal cell migration." [GOC:mtg_kidney_jan10, GOC:obol, GOC:yaf]


id: GO:2000592
name: regulation of metanephric DCT cell differentiation
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of metanephric DCT cell differentiation." [GOC:obol]


id: GO:2000593
name: negative regulation of metanephric DCT cell differentiation
namespace: biological_process
def:
  "Any process that stops, prevents or reduces the frequency, rate or extent of metanephric DCT cell differentiation." [GOC:obol]


id: GO:2000594
name: positive regulation of metanephric DCT cell differentiation
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of metanephric DCT cell differentiation." [GOC:obol]


id: GO:2000596
name: negative regulation of optic nerve formation
namespace: biological_process
def:
  "Any process that stops, prevents or reduces the frequency, rate or extent of optic nerve formation." [GOC:obol]


id: GO:2000597
name: positive regulation of optic nerve formation
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of optic nerve formation." [GOC:obol]


id: GO:2000599
name: negative regulation of cyclin catabolic process
namespace: biological_process
def:
  "Any process that stops, prevents or reduces the frequency, rate or extent of cyclin catabolic process." [GOC:obol]


id: GO:2000600
name: positive regulation of cyclin catabolic process
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of cyclin catabolic process." [GOC:obol]


id: GO:2000601
name: positive regulation of Arp2/3 complex-mediated actin nucleation
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of Arp2/3 complex-mediated actin nucleation." [PMID:21454476]


id: GO:2000602
name: obsolete regulation of interphase of mitotic cell cycle
namespace: biological_process
def:
  "OBSOLETE. Any process that modulates the frequency, rate or extent of interphase of mitotic cell cycle." [GOC:obol]


id: GO:2000604
name: negative regulation of secondary growth
namespace: biological_process
def:
  "Any process that stops, prevents or reduces the frequency, rate or extent of secondary growth." [GOC:obol]


id: GO:2000605
name: positive regulation of secondary growth
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of secondary growth." [GOC:obol]


id: GO:2000606
name: regulation of cell proliferation involved in mesonephros development
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of cell proliferation involved in mesonephros development." [GOC:obol]


id: GO:2000607
name: negative regulation of cell proliferation involved in mesonephros development
namespace: biological_process
def:
  "Any process that stops, prevents or reduces the frequency, rate or extent of cell proliferation involved in mesonephros development." [GOC:obol]


id: GO:2000608
name: positive regulation of cell proliferation involved in mesonephros development
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of cell proliferation involved in mesonephros development." [GOC:obol]


id: GO:2000609
name: regulation of thyroid hormone generation
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of thyroid hormone generation." [GOC:obol]


id: GO:2000610
name: negative regulation of thyroid hormone generation
namespace: biological_process
def:
  "Any process that stops, prevents or reduces the frequency, rate or extent of thyroid hormone generation." [GOC:obol]


id: GO:2000611
name: positive regulation of thyroid hormone generation
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of thyroid hormone generation." [GOC:obol]


id: GO:2000612
name: regulation of thyroid-stimulating hormone secretion
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of thyroid-stimulating hormone secretion." [GOC:obol]


id: GO:2000613
name: negative regulation of thyroid-stimulating hormone secretion
namespace: biological_process
def:
  "Any process that stops, prevents or reduces the frequency, rate or extent of thyroid-stimulating hormone secretion." [GOC:obol]


id: GO:2000614
name: positive regulation of thyroid-stimulating hormone secretion
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of thyroid-stimulating hormone secretion." [GOC:obol]


id: GO:2000616
name: negative regulation of histone H3-K9 acetylation
namespace: biological_process
def:
  "Any process that stops, prevents or reduces the frequency, rate or extent of histone H3-K9 acetylation." [GOC:BHF]


id: GO:2000617
name: positive regulation of histone H3-K9 acetylation
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of histone H3-K9 acetylation." [GOC:BHF]


id: GO:2000619
name: negative regulation of histone H4-K16 acetylation
namespace: biological_process
def:
  "Any process that stops, prevents or reduces the frequency, rate or extent of histone H4-K16 acetylation." [GOC:BHF]


id: GO:2000620
name: positive regulation of histone H4-K16 acetylation
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of histone H4-K16 acetylation." [GOC:BHF]


id: GO:2000621
name: regulation of DNA replication termination
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of DNA replication termination." [GOC:obol]


id: GO:2000622
name: regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay." [GOC:obol]


id: GO:2000623
name: negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
namespace: biological_process
def:
  "Any process that stops, prevents or reduces the frequency, rate or extent of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay." [GOC:obol]


id: GO:2000624
name: positive regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay." [GOC:obol]


id: GO:2000626
name: negative regulation of miRNA catabolic process
namespace: biological_process
def:
  "Any process that stops, prevents or reduces the frequency, rate or extent of miRNA catabolic process." [GOC:dph]


id: GO:2000627
name: positive regulation of miRNA catabolic process
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of miRNA catabolic process." [GOC:dph]


id: GO:2000629
name: negative regulation of miRNA metabolic process
namespace: biological_process
def:
  "Any process that stops, prevents or reduces the frequency, rate or extent of miRNA metabolic process." [GOC:dph]


id: GO:2000630
name: positive regulation of miRNA metabolic process
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of miRNA metabolic process." [GOC:dph]


id: GO:2000631
name: regulation of pre-miRNA processing
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of pre-microRNA processing." [GOC:dph, GOC:sl]


id: GO:2000632
name: negative regulation of pre-miRNA processing
namespace: biological_process
def:
  "Any process that stops, prevents or reduces the frequency, rate or extent of pre-microRNA processing." [GOC:dph, GOC:sl]


id: GO:2000633
name: positive regulation of pre-miRNA processing
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of pre-microRNA processing." [GOC:dph, GOC:sl]


id: GO:2000634
name: regulation of primary miRNA processing
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of primary microRNA processing." [GOC:dph, GOC:sl]


id: GO:2000635
name: negative regulation of primary miRNA processing
namespace: biological_process
def:
  "Any process that stops, prevents or reduces the frequency, rate or extent of primary microRNA processing." [GOC:dph, GOC:sl]


id: GO:2000636
name: positive regulation of primary miRNA processing
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of primary microRNA processing." [GOC:dph, GOC:sl]


id: GO:2000637
name: positive regulation of gene silencing by miRNA
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of gene silencing by miRNA." [GOC:dph]


id: GO:2000638
name: regulation of SREBP signaling pathway
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of the SREBP signaling pathway." [GOC:BHF]


id: GO:2000639
name: negative regulation of SREBP signaling pathway
namespace: biological_process
def:
  "Any process that stops, prevents or reduces the frequency, rate or extent of the SREBP signaling pathway." [GOC:BHF]


id: GO:2000640
name: positive regulation of SREBP signaling pathway
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of the SREBP signaling pathway." [GOC:BHF]


id: GO:2000641
name: regulation of early endosome to late endosome transport
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of early endosome to late endosome transport." [GOC:BHF]


id: GO:2000642
name: negative regulation of early endosome to late endosome transport
namespace: biological_process
def:
  "Any process that stops, prevents or reduces the frequency, rate or extent of early endosome to late endosome transport." [GOC:BHF]


id: GO:2000643
name: positive regulation of early endosome to late endosome transport
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of early endosome to late endosome transport." [GOC:BHF]


id: GO:2000645
name: negative regulation of receptor catabolic process
namespace: biological_process
def:
  "Any process that stops, prevents or reduces the frequency, rate or extent of receptor catabolic process." [GOC:BHF]


id: GO:2000646
name: positive regulation of receptor catabolic process
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of receptor catabolic process." [GOC:BHF]


id: GO:2000647
name: negative regulation of stem cell proliferation
namespace: biological_process
def:
  "Any process that stops, prevents or reduces the frequency, rate or extent of stem cell proliferation." [GOC:dph]


id: GO:2000648
name: positive regulation of stem cell proliferation
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of stem cell proliferation." [GOC:dph]


id: GO:2000649
name: regulation of sodium ion transmembrane transporter activity
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of sodium ion transmembrane transporter activity." [GOC:obol]


id: GO:2000650
name: negative regulation of sodium ion transmembrane transporter activity
namespace: biological_process
def:
  "Any process that stops, prevents or reduces the frequency, rate or extent of sodium ion transmembrane transporter activity." [GOC:obol]


id: GO:2000651
name: positive regulation of sodium ion transmembrane transporter activity
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of sodium ion transmembrane transporter activity." [GOC:obol]


id: GO:2000652
name: regulation of secondary cell wall biogenesis
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of secondary cell wall biogenesis." [GOC:obol]


id: GO:2000654
name: regulation of cellular response to testosterone stimulus
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of cellular response to testosterone stimulus." [GOC:BHF]


id: GO:2000655
name: negative regulation of cellular response to testosterone stimulus
namespace: biological_process
def:
  "Any process that stops, prevents or reduces the frequency, rate or extent of cellular response to testosterone stimulus." [GOC:BHF]


id: GO:2000657
name: negative regulation of apolipoprotein binding
namespace: biological_process
def:
  "Any process that stops, prevents or reduces the frequency, rate or extent of apolipoprotein binding." [GOC:BHF]


id: GO:2000658
name: positive regulation of apolipoprotein binding
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of apolipoprotein binding." [GOC:BHF]


id: GO:2000659
name: regulation of interleukin-1-mediated signaling pathway
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of interleukin-1-mediated signaling pathway." [GOC:obol]


id: GO:2000660
name: negative regulation of interleukin-1-mediated signaling pathway
namespace: biological_process
def:
  "Any process that stops, prevents or reduces the frequency, rate or extent of interleukin-1-mediated signaling pathway." [GOC:obol]


id: GO:2000661
name: positive regulation of interleukin-1-mediated signaling pathway
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of interleukin-1-mediated signaling pathway." [GOC:obol]


id: GO:2000663
name: negative regulation of interleukin-5 secretion
namespace: biological_process
def:
  "Any process that stops, prevents or reduces the frequency, rate or extent of interleukin-5 secretion." [GOC:obol]


id: GO:2000664
name: positive regulation of interleukin-5 secretion
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of interleukin-5 secretion." [GOC:obol]


id: GO:2000666
name: negative regulation of interleukin-13 secretion
namespace: biological_process
def:
  "Any process that stops, prevents or reduces the frequency, rate or extent of interleukin-13 secretion." [GOC:obol]


id: GO:2000667
name: positive regulation of interleukin-13 secretion
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of interleukin-13 secretion." [GOC:obol]


id: GO:2000668
name: regulation of dendritic cell apoptotic process
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of dendritic cell apoptotic process." [GOC:mtg_apoptosis, GOC:obol]


id: GO:2000669
name: negative regulation of dendritic cell apoptotic process
namespace: biological_process
def:
  "Any process that stops, prevents or reduces the frequency, rate or extent of dendritic cell apoptotic process." [GOC:mtg_apoptosis, GOC:obol]


id: GO:2000670
name: positive regulation of dendritic cell apoptotic process
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of dendritic cell apoptotic process." [GOC:mtg_apoptosis, GOC:obol]


id: GO:2000671
name: regulation of motor neuron apoptotic process
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of motor neuron apoptotic process." [GOC:mtg_apoptosis, GOC:obol]


id: GO:2000672
name: negative regulation of motor neuron apoptotic process
namespace: biological_process
def:
  "Any process that stops, prevents or reduces the frequency, rate or extent of motor neuron apoptotic process." [GOC:mtg_apoptosis, GOC:obol]


id: GO:2000673
name: positive regulation of motor neuron apoptotic process
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of motor neuron apoptotic process." [GOC:mtg_apoptosis, GOC:obol]


id: GO:2000674
name: regulation of type B pancreatic cell apoptotic process
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of type B pancreatic cell apoptotic process." [GOC:mtg_apoptosis, GOC:obol]


