# go

id: GO:0001818
name: negative regulation of cytokine production
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the rate of production of a cytokine." [GOC:add, ISBN:0781735149]


id: GO:0001819
name: positive regulation of cytokine production
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of production of a cytokine." [GOC:add, ISBN:0781735149]


id: GO:0001820
name: serotonin secretion
namespace: biological_process
def:
  "The regulated release of serotonin by a cell. Serotonin (5-hydroxytryptamine, or 5-HT) is a monoamine synthesised in serotonergic neurons in the central nervous system, enterochromaffin cells in the gastrointestinal tract and some immune system cells." [GOC:ef, ISBN:0198506732, ISBN:0781735149]


id: GO:0001821
name: histamine secretion
namespace: biological_process
def:
  "The regulated release of histamine by a cell or tissue. It is formed by decarboxylation of histidine and it acts through receptors in smooth muscle and in secretory systems." [GOC:mah, ISBN:0198506732, ISBN:0781735149]


id: GO:0001822
name: kidney development
namespace: biological_process
def:
  "The process whose specific outcome is the progression of the kidney over time, from its formation to the mature structure. The kidney is an organ that filters the blood and/or excretes the end products of body metabolism in the form of urine." [GOC:dph, GOC:mtg_kidney_jan10, ISBN:0124020607, ISBN:0721662544]


id: GO:0001823
name: mesonephros development
namespace: biological_process
def:
  "The process whose specific outcome is the progression of the mesonephros over time, from its formation to the mature structure. In mammals, the mesonephros is the second of the three embryonic kidneys to be established and exists only transiently. In lower vertebrates such as fish and amphibia, the mesonephros will form the mature kidney." [GOC:dph, ISBN:0124020607, ISBN:0721662544, PMID:10535314]


id: GO:0001824
name: blastocyst development
namespace: biological_process
def:
  "The process whose specific outcome is the progression of the blastocyst over time, from its formation to the mature structure. The mammalian blastocyst is a hollow ball of cells containing two cell types, the inner cell mass and the trophectoderm." [GOC:dph, ISBN:0124020607, ISBN:0198542771]


id: GO:0001825
name: blastocyst formation
namespace: biological_process
def:
  "The initial formation of a blastocyst from a solid ball of cells known as a morula." [GOC:dph, ISBN:0124020607, ISBN:0198542771]


id: GO:0001826
name: inner cell mass cell differentiation
namespace: biological_process
def:
  "The process in which a relatively unspecialized cell acquires specialized features of an inner cell mass cell." [GOC:dph, ISBN:0124020607, ISBN:0198542771]


id: GO:0001827
name: inner cell mass cell fate commitment
namespace: biological_process
def:
  "The cell fate commitment of precursor cells that will become inner cell mass cells." [GOC:dph, ISBN:0124020607, ISBN:0198542771]


id: GO:0001829
name: trophectodermal cell differentiation
namespace: biological_process
def:
  "The process in which a relatively unspecialized cell acquires the specialized features of a trophectoderm cell." [GOC:dph, ISBN:0124020607, ISBN:0198542771]


id: GO:0001830
name: trophectodermal cell fate commitment
namespace: biological_process
def:
  "The cell fate commitment of precursor cells that will become trophectoderm cells." [GOC:dph, ISBN:0124020607, ISBN:0198542771]


id: GO:0001832
name: blastocyst growth
namespace: biological_process
def:
  "An increase in size of a blastocyst due to expansion of the blastocoelic cavity cell shape changes and cell proliferation." [GOC:dph, ISBN:0124020607, ISBN:0198542771]


id: GO:0001833
name: inner cell mass cell proliferation
namespace: biological_process
def:
  "The proliferation of cells in the inner cell mass." [GOC:dph, GOC:isa_complete, ISBN:0124020607, ISBN:0198542771]


id: GO:0001835
name: blastocyst hatching
namespace: biological_process
def:
  "The hatching of the cellular blastocyst from the zona pellucida." [GOC:dph, ISBN:0124020607, ISBN:0198542771]


id: GO:0001836
name: release of cytochrome c from mitochondria
namespace: biological_process
def:
  "The process that results in the movement of cytochrome c from the mitochondrial intermembrane space into the cytosol, which is part of the apoptotic signaling pathway and leads to caspase activation." [GOC:add, GOC:mah, GOC:mtg_apoptosis, ISBN:0721639976, PMID:12925707, PMID:9560217]


id: GO:0001837
name: epithelial to mesenchymal transition
namespace: biological_process
def:
  "A transition where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell." [GOC:dph, PMID:14701881]


id: GO:0001838
name: embryonic epithelial tube formation
namespace: biological_process
def:
  "The morphogenesis of an embryonic epithelium into a tube-shaped structure." [GOC:dph, ISBN:0824072820]


id: GO:0001839
name: neural plate morphogenesis
namespace: biological_process
def:
  "The process in which the anatomical structures of the neural plate are generated and organized. The neural plate is a specialized region of columnar epithelial cells in the dorsal ectoderm that will give rise to nervous system tissue." [GOC:dph, ISBN:0878932437]


id: GO:0001840
name: neural plate development
namespace: biological_process
def:
  "The process whose specific outcome is the progression of the neural plate over time, from its formation to the mature structure. The neural plate is a flat, thickened layer of ectodermal cells. The underlying dorsal mesoderm signals the ectodermal cells above it to elongate into columnar neural plate cells. The neural plate subsequently develops into the neural tube, which gives rise to the central nervous system." [GOC:dph, GOC:ef, ISBN:0878932437, ISBN:0878932585]


id: GO:0001841
name: neural tube formation
namespace: biological_process
def:
  "The formation of a tube from the flat layer of ectodermal cells known as the neural plate. This will give rise to the central nervous system." [GOC:dph, ISBN:0878932437]


id: GO:0001842
name: neural fold formation
namespace: biological_process
def:
  "The process in which the neural fold is formed. The edges of the neural plate thicken and move up to form a U-shaped structure called the neural groove." [GOC:dph, ISBN:0878932437]


id: GO:0001843
name: neural tube closure
namespace: biological_process
def:
  "The last step in the formation of the neural tube, where the paired neural folds are brought together and fuse at the dorsal midline." [GOC:dph, ISBN:0878932437]


id: GO:0001844
name: protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
namespace: biological_process
def:
  "The process in which a protein is incorporated into a mitochondrial membrane as the initial phase of the mitochondrial membrane permeabilization that takes place in the apoptotic signaling pathway." [GOC:add, GOC:mtg_apoptosis, PMID:12952892]


id: GO:0001845
name: phagolysosome assembly
namespace: biological_process
def:
  "The process that results in the fusion of a phagosome, a vesicle formed by phagocytosis, with a lysosome." [GOC:add, ISBN:0781735149]


id: GO:0001846
name: opsonin binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with an opsonin, such as a complement component or antibody, deposited on the surface of a bacteria, virus, immune complex, or other particulate material." [GOC:add, ISBN:0781735149]


id: GO:0001847
name: opsonin receptor activity
namespace: molecular_function
def:
  "Combining with an opsonin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:add, GOC:signaling, ISBN:0781735149]


id: GO:0001848
name: complement binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with any component or product of the complement cascade." [GOC:add, ISBN:0781735149]


id: GO:0001849
name: complement component C1q binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with the C1q component of the classical complement cascade." [GOC:add, ISBN:0781735149]


id: GO:0001850
name: complement component C3a binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with the C3a product of the complement cascade." [GOC:add, ISBN:0781735149]


id: GO:0001851
name: complement component C3b binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with the C3b product of the complement cascade." [GOC:add, ISBN:0781735149]


id: GO:0001852
name: complement component iC3b binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with the iC3b product of the complement cascade." [GOC:add, ISBN:0781735149]


id: GO:0001853
name: complement component C3dg binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with the C3dg product of the complement cascade." [GOC:add, ISBN:0781735149]


id: GO:0001854
name: complement component C3d binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with the C3d product of the complement cascade." [GOC:add, ISBN:0781735149]


id: GO:0001855
name: complement component C4b binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with the C4b product of the classical complement cascade." [GOC:add, ISBN:0781735149]


id: GO:0001856
name: complement component C5a binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with the C5a product of the complement cascade." [GOC:add, ISBN:0781735149]


id: GO:0001857
name: complement component C1q receptor activity
namespace: molecular_function
def:
  "Combining with the C1q component of the classical complement cascade and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:add, GOC:signaling, ISBN:0781735149]


id: GO:0001858
name: complement component iC3b receptor activity
namespace: molecular_function
def:
  "Combining with the iC3b product of the complement cascade and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:add, GOC:signaling, ISBN:0781735149]


id: GO:0001859
name: complement component C3dg receptor activity
namespace: molecular_function
def:
  "Combining with the C3dg product of the complement cascade and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:add, GOC:signaling, ISBN:0781735149]


id: GO:0001860
name: complement component C3d receptor activity
namespace: molecular_function
def:
  "Combining with the C3d product of the complement cascade and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:add, GOC:signaling, ISBN:0781735149]


id: GO:0001861
name: complement component C4b receptor activity
namespace: molecular_function
def:
  "Combining with the C4b product of the classical complement cascade and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:add, GOC:signaling, ISBN:0781735149]


id: GO:0001862
name: collectin binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with a collectin, a member of a group of structurally related pattern recognition molecules characterized by having a carbohydrate recognition domain of the C-type lectin family at the C-terminus and a collagenous domain at the N-terminus." [GOC:add, ISBN:0781735149]


id: GO:0001863
name: collectin receptor activity
namespace: molecular_function
def:
  "Combining with a collectin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:add, GOC:signaling, ISBN:0781735149]


id: GO:0001864
name: pentraxin binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with a pentraxin, a member of a family of inflammatory proteins with a radially symmetric arrangement of five identical, noncovalently linked chains in a pentagonal array." [GOC:add, ISBN:0781735149]


id: GO:0001865
name: NK T cell differentiation
namespace: biological_process
def:
  "The process in which a precursor cell type acquires the specialized features of a NK T cell." [GOC:add, ISBN:0781735149, PMID:10704459]


id: GO:0001866
name: NK T cell proliferation
namespace: biological_process
def:
  "The expansion of a NK T cell population by cell division." [GOC:add, ISBN:0781735149, PMID:10704459]


id: GO:0001867
name: complement activation, lectin pathway
namespace: biological_process
def:
  "Any process involved in the activation of any of the steps of the lectin pathway of the complement cascade which allows for the direct killing of microbes and the regulation of other immune processes." [GOC:add, ISBN:0781735149]


id: GO:0001868
name: regulation of complement activation, lectin pathway
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of the lectin pathway of complement activation." [GOC:add, ISBN:0781735149]


id: GO:0001869
name: negative regulation of complement activation, lectin pathway
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the rate of complement activation by the lectin pathway." [GOC:add, ISBN:0781735149]


id: GO:0001870
name: positive regulation of complement activation, lectin pathway
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of complement activation by the lectin pathway." [GOC:add, ISBN:0781735149]


id: GO:0001871
name: pattern binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with a repeating or polymeric structure, such as a polysaccharide or peptidoglycan." [PMID:12072369, PMID:12225919, PMID:12507420, PMID:12925128, PMID:14523544]


id: GO:0001873
name: polysaccharide receptor activity
namespace: molecular_function
def:
  "Combining with a polysaccharide and transmitting the signal to initiate a change in cell activity. A polysaccharide is a polymer of many (typically more than 10) monosaccharide residues linked glycosidically." [CHEBI:18154, PMID:14707091]


id: GO:0001875
name: lipopolysaccharide receptor activity
namespace: molecular_function
def:
  "Combining with a lipopolysaccharide and transmitting the signal across the cell membrane to initiate a change in cell activity. Lipopolysaccharides (LPS) are major components of the outer membrane of Gram-negative bacteria, making them prime targets for recognition by the immune system." [PMID:14609719, PMID:15379975]


id: GO:0001877
name: lipoarabinomannan receptor activity
namespace: molecular_function
def:
  "Combining with lipoarabinomannan and transmitting the signal to initiate a change in cell activity." [PMID:10586073]


id: GO:0001878
name: response to yeast
namespace: biological_process
def:
  "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a yeast species." [PMID:14707091]


id: GO:0001879
name: detection of yeast
namespace: biological_process
def:
  "The series of events in which a stimulus from a yeast is received and converted into a molecular signal." [PMID:14707091]


id: GO:0001880
name: Mullerian duct regression
namespace: biological_process
def:
  "The process in which the Mullerian ducts, primordia of the oviducts, uterus and upper vagina, undergo regression in male embryos." [GOC:dph, PMID:12368913]


id: GO:0001881
name: receptor recycling
namespace: biological_process
def:
  "The process that results in the return of receptor molecules to an active state and an active cellular location after they have been stimulated by a ligand. An active state is when the receptor is ready to receive a signal." [GOC:dph]


id: GO:0001882
name: nucleoside binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with a nucleoside, a compound consisting of a purine or pyrimidine nitrogenous base linked either to ribose or deoxyribose." [GOC:hjd]


id: GO:0001883
name: purine nucleoside binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with a purine nucleoside, a compound consisting of a purine base linked either to ribose or deoxyribose." [GOC:hjd]


id: GO:0001884
name: pyrimidine nucleoside binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with a pyrimidine nucleoside, a compound consisting of a pyrimidine base linked either to ribose or deoxyribose." [GOC:hjd]


id: GO:0001885
name: endothelial cell development
namespace: biological_process
def:
  "The progression of an endothelial cell over time, from its formation to the mature structure." [GOC:dph]


id: GO:0001886
name: endothelial cell morphogenesis
namespace: biological_process
def:
  "The change in form (cell shape and size) that occurs during the differentiation of an endothelial cell." [GOC:ascb_2009, GOC:dph, GOC:tb]


id: GO:0001887
name: selenium compound metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving compounds that contain selenium, such as selenocysteine." [PMID:12730456]


id: GO:0001888
name: glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + beta-D-glucuronosyl-(1->3)-beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-xylosyl-proteoglycan = UDP + alpha-N-acetyl-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)-beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-xylosyl-proteoglycan." [EC:2.4.1.223]


id: GO:0001889
name: liver development
namespace: biological_process
def:
  "The process whose specific outcome is the progression of the liver over time, from its formation to the mature structure. The liver is an exocrine gland which secretes bile and functions in metabolism of protein and carbohydrate and fat, synthesizes substances involved in the clotting of the blood, synthesizes vitamin A, detoxifies poisonous substances, stores glycogen, and breaks down worn-out erythrocytes." [GOC:add, ISBN:068340007X]


id: GO:0001890
name: placenta development
namespace: biological_process
def:
  "The process whose specific outcome is the progression of the placenta over time, from its formation to the mature structure. The placenta is an organ of metabolic interchange between fetus and mother, partly of embryonic origin and partly of maternal origin." [GOC:add, ISBN:068340007X]


id: GO:0001891
name: phagocytic cup
namespace: cellular_component
def:
  "An invagination of the cell membrane formed by an actin dependent process during phagocytosis. Following internalization it is converted into a phagosome." [PMID:10358769]


id: GO:0001892
name: embryonic placenta development
namespace: biological_process
def:
  "The embryonically driven process whose specific outcome is the progression of the placenta over time, from its formation to the mature structure. The placenta is an organ of metabolic interchange between fetus and mother, partly of embryonic origin and partly of maternal origin." [GOC:add, ISBN:068340007X]


id: GO:0001893
name: maternal placenta development
namespace: biological_process
def:
  "Maternally driven process whose specific outcome is the progression of the placenta over time, from its formation to the mature structure. The placenta is an organ of metabolic interchange between fetus and mother, partly of embryonic origin and partly of maternal origin." [GOC:add, ISBN:068340007X]


id: GO:0001894
name: tissue homeostasis
namespace: biological_process
def:
  "A homeostatic process involved in the maintenance of an internal steady state within a defined tissue of an organism, including control of cellular proliferation and death and control of metabolic function." [GOC:add, GOC:isa_complete]


id: GO:0001895
name: retina homeostasis
namespace: biological_process
def:
  "A tissue homeostatic process involved in the maintenance of an internal equilibrium within the retina of the eye, including control of cellular proliferation and death and control of metabolic function." [GOC:add, GOC:dph, GOC:tb, PMID:15365173, PMID:15365178]


id: GO:0001897
name: cytolysis by symbiont of host cells
namespace: biological_process
def:
  "The killing by an organism of a cell in its host organism by means of the rupture of cell membranes and the loss of cytoplasm. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:add]


id: GO:0001898
name: regulation of cytolysis by symbiont of host cells
namespace: biological_process
def:
  "Any process in which an organism modulates the frequency, rate or extent of the cytolysis by that organism of cells in its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:add, GOC:dph, GOC:tb]


id: GO:0001899
name: negative regulation of cytolysis by symbiont of host cells
namespace: biological_process
def:
  "Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of cytolysis by that organism of cells in its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:add, GOC:dph, GOC:tb]


id: GO:0001900
name: positive regulation of cytolysis by symbiont of host cells
namespace: biological_process
def:
  "Any process in which an organism activates or increases the frequency, rate or extent of cytolysis by that organism of cells in its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:add, GOC:dph, GOC:tb]


id: GO:0001905
name: activation of membrane attack complex
namespace: biological_process
def:
  "The activation of the membrane attack complex components of the complement cascade which can result in death of a target cell through cytolysis." [GOC:add, ISBN:0781735149]


id: GO:0001906
name: cell killing
namespace: biological_process
def:
  "Any process in an organism that results in the killing of its own cells or those of another organism, including in some cases the death of the other organism. Killing here refers to the induction of death in one cell by another cell, not cell-autonomous death due to internal or other environmental conditions." [GOC:add]


id: GO:0001907
name: killing by symbiont of host cells
namespace: biological_process
def:
  "Any process mediated by an organism that results in the death of cells in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:add]


id: GO:0001909
name: leukocyte mediated cytotoxicity
namespace: biological_process
def:
  "The directed killing of a target cell by a leukocyte." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:0781735149, PMID:11911826]


id: GO:0001910
name: regulation of leukocyte mediated cytotoxicity
namespace: biological_process
def:
  "Any process that modulates the frequency, rate, or extent of leukocyte mediated cytotoxicity." [GOC:add, ISBN:0781735149, PMID:11911826]


id: GO:0001911
name: negative regulation of leukocyte mediated cytotoxicity
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the rate of leukocyte mediated cytotoxicity." [GOC:add, ISBN:0781735149, PMID:11911826]


id: GO:0001912
name: positive regulation of leukocyte mediated cytotoxicity
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of leukocyte mediated cytotoxicity." [GOC:add, ISBN:0781735149, PMID:11911826]


id: GO:0001913
name: T cell mediated cytotoxicity
namespace: biological_process
def:
  "The directed killing of a target cell by a T cell through the release of granules containing cytotoxic mediators or through the engagement of death receptors." [GOC:add, GOC:pr, ISBN:0781735149, PMID:11911826]


id: GO:0001914
name: regulation of T cell mediated cytotoxicity
namespace: biological_process
def:
  "Any process that modulates the frequency, rate, or extent of T cell mediated cytotoxicity." [GOC:add, ISBN:0781735149]


id: GO:0001915
name: negative regulation of T cell mediated cytotoxicity
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the rate of T cell mediated cytotoxicity." [GOC:add, ISBN:0781735149]


id: GO:0001916
name: positive regulation of T cell mediated cytotoxicity
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of T cell mediated cytotoxicity." [GOC:add, ISBN:0781735149]


id: GO:0001917
name: photoreceptor inner segment
namespace: cellular_component
def:
  "The inner segment of a vertebrate photoreceptor containing mitochondria, ribosomes and membranes where opsin molecules are assembled and passed to be part of the outer segment discs." [GOC:add, PMID:12019563]


id: GO:0001921
name: positive regulation of receptor recycling
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of receptor recycling." [GOC:add]


id: GO:0001922
name: B-1 B cell homeostasis
namespace: biological_process
def:
  "The process of regulating the proliferation and elimination of B cells of the B-1 subset such that the total number of B-1 B cells within a whole or part of an organism is stable over time in the absence of an outside stimulus. B-1 B cells are a distinct subset of B cells characterized as being CD5 positive, found predominantly in the peritoneum, pleural cavities, and spleen, and enriched for self-reactivity." [GOC:add, ISBN:0781735149]


id: GO:0001923
name: B-1 B cell differentiation
namespace: biological_process
def:
  "The process in which a hemopoietic stem cell acquires the specialized features of a B-1 B cell. B-1 B cells are a distinct subset of B cells characterized as being CD5 positive, found predominantly in the peritoneum, pleural cavities, and spleen, and enriched for self-reactivity." [GOC:add, ISBN:0781735149]


id: GO:0001924
name: regulation of B-1 B cell differentiation
namespace: biological_process
def:
  "Any process that modulates the frequency, rate, or extent of B-1 B cell differentiation. B-1 B cells are a distinct subset of B cells characterized as being CD5 positive, found predominantly in the peritoneum, pleural cavities, and spleen, and enriched for self-reactivity." [GOC:add, ISBN:0781735149]


id: GO:0001925
name: negative regulation of B-1 B cell differentiation
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the rate of B-1 B cell differentiation." [GOC:add, ISBN:0781735149]


id: GO:0001926
name: positive regulation of B-1 B cell differentiation
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of B-1 B cell differentiation." [GOC:add, ISBN:0781735149]


id: GO:0001927
name: exocyst assembly
namespace: biological_process
def:
  "The aggregation, arrangement and bonding together of various polypeptides into the exocyst complex." [GOC:hjd, PMID:9700152, Wikipedia:Exocyst]


id: GO:0001931
name: uropod
namespace: cellular_component
def:
  "A membrane projection with related cytoskeletal components at the trailing edge of a cell in the process of migrating or being activated, found on the opposite side of the cell from the leading edge or immunological synapse, respectively." [GOC:add, ISBN:0781735149, PMID:12714569, PMID:12787750]


id: GO:0001932
name: regulation of protein phosphorylation
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of addition of phosphate groups into an amino acid in a protein." [GOC:hjd]


id: GO:0001933
name: negative regulation of protein phosphorylation
namespace: biological_process
def:
  "Any process that stops, prevents or reduces the rate of addition of phosphate groups to amino acids within a protein." [GOC:hjd]


id: GO:0001934
name: positive regulation of protein phosphorylation
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to amino acids within a protein." [GOC:hjd]


id: GO:0001935
name: endothelial cell proliferation
namespace: biological_process
def:
  "The multiplication or reproduction of endothelial cells, resulting in the expansion of a cell population. Endothelial cells are thin flattened cells which line the inside surfaces of body cavities, blood vessels, and lymph vessels, making up the endothelium." [GOC:add, ISBN:0781735149]


id: GO:0001936
name: regulation of endothelial cell proliferation
namespace: biological_process
def:
  "Any process that modulates the frequency, rate, or extent of endothelial cell proliferation." [GOC:add]


id: GO:0001937
name: negative regulation of endothelial cell proliferation
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the rate or extent of endothelial cell proliferation." [GOC:add]


id: GO:0001938
name: positive regulation of endothelial cell proliferation
namespace: biological_process
def:
  "Any process that activates or increases the rate or extent of endothelial cell proliferation." [GOC:add]


id: GO:0001940
name: male pronucleus
namespace: cellular_component
def:
  "The pronucleus originating from the spermatozoa that was involved in fertilization." [GOC:hjd, ISBN:0198506732]


id: GO:0001941
name: postsynaptic membrane organization
namespace: biological_process
def:
  "A process which results in the assembly, arrangement of constituent parts, or disassembly of a postsynaptic membrane, the specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft)." [GOC:dph, GOC:pr]


id: GO:0001942
name: hair follicle development
namespace: biological_process
def:
  "The process whose specific outcome is the progression of the hair follicle over time, from its formation to the mature structure. A hair follicle is a tube-like opening in the epidermis where the hair shaft develops and into which the sebaceous glands open." [GOC:dph, UBERON:0002073]


id: GO:0001944
name: vasculature development
namespace: biological_process
def:
  "The process whose specific outcome is the progression of the vasculature over time, from its formation to the mature structure. The vasculature is an interconnected tubular multi-tissue structure that contains fluid that is actively transported around the organism." [GOC:dph, UBERON:0002409]


id: GO:0001945
name: lymph vessel development
namespace: biological_process
def:
  "The process whose specific outcome is the progression of a lymph vessel over time, from its formation to the mature structure." [GOC:dph, UBERON:0001473]


id: GO:0001946
name: lymphangiogenesis
namespace: biological_process
def:
  "Lymph vessel formation when new vessels emerge from the proliferation of pre-existing vessels." [GOC:dph, PMID:11596157]


id: GO:0001947
name: heart looping
namespace: biological_process
def:
  "The tube morphogenesis process in which the primitive heart tube loops asymmetrically. This looping brings the primitive heart chambers into alignment preceding their future integration. Heart looping begins with dextral-looping and ends when the main regional divisions of the mature heart and primordium of the great arterial trunks become established preceeding septation." [GOC:dph, PMID:12094232]


id: GO:0001948
name: glycoprotein binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with a glycoprotein, a protein that contains covalently bound glycose (monosaccharide) residues. These also include proteoglycans." [GOC:hjd, ISBN:0198506732]


id: GO:0001949
name: sebaceous gland cell differentiation
namespace: biological_process
def:
  "The process in which a relatively unspecialized epidermal cell acquires the specialized features of a sebaceous gland cell." [GOC:mgi_curators, PMID:15737203]


id: GO:0001950
name: obsolete plasma membrane enriched fraction
namespace: cellular_component
def:
  "OBSOLETE: The fraction of cells, prepared by disruptive biochemical methods, that is enriched for plasma membranes." [GOC:mgi_curators, PMID:11562363, PMID:15601832]


id: GO:0001951
name: intestinal D-glucose absorption
namespace: biological_process
def:
  "Uptake of D-glucose into the blood by absorption from the small intestine." [GOC:mgi_curators, PMID:5601832]


id: GO:0001952
name: regulation of cell-matrix adhesion
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of attachment of a cell to the extracellular matrix." [GOC:hjd]


id: GO:0001953
name: negative regulation of cell-matrix adhesion
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the rate or extent of cell adhesion to the extracellular matrix." [GOC:hjd]


id: GO:0001954
name: positive regulation of cell-matrix adhesion
namespace: biological_process
def:
  "Any process that activates or increases the rate or extent of cell adhesion to an extracellular matrix." [GOC:hjd]


id: GO:0001955
name: blood vessel maturation
namespace: biological_process
def:
  "A developmental process, independent of morphogenetic (shape) change, that is required for a blood vessel to attain its fully functional state." [GOC:dph]


id: GO:0001956
name: positive regulation of neurotransmitter secretion
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of the regulated release of a neurotransmitter." [GOC:hjd]


id: GO:0001957
name: intramembranous ossification
namespace: biological_process
def:
  "Direct ossification that occurs within mesenchyme or an accumulation of relatively unspecialized cells." [ISBN:0878932437]


id: GO:0001958
name: endochondral ossification
namespace: biological_process
def:
  "Replacement ossification wherein bone tissue replaces cartilage." [GO_REF:0000034, ISBN:0878932437]


id: GO:0001959
name: regulation of cytokine-mediated signaling pathway
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of the cytokine mediated signaling pathway." [GOC:hjd]


id: GO:0001960
name: negative regulation of cytokine-mediated signaling pathway
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of the cytokine mediated signaling pathway." [GOC:hjd]


id: GO:0001961
name: positive regulation of cytokine-mediated signaling pathway
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of a cytokine mediated signaling pathway." [GOC:hjd]


id: GO:0001962
name: alpha-1,3-galactosyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the transfer of a galactose residue from a donor molecule, such as GDP-galactose or UDP-galactose, to an oligosaccharide, forming an alpha-(1->3) linkage." [GOC:hjd, PMID:10854427]


id: GO:0001963
name: synaptic transmission, dopaminergic
namespace: biological_process
def:
  "The process of communication from a neuron to another neuron across a synapse using the neurotransmitter dopamine." [GOC:dph]


id: GO:0001965
name: G-protein alpha-subunit binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with a G-protein alpha subunit. The alpha subunit binds a guanine nucleotide." [GOC:hjd]


id: GO:0001967
name: suckling behavior
namespace: biological_process
def:
  "Specific behavior of a newborn or infant mammal that results in the derivation of nourishment from the breast." [GOC:dph, GOC:pr]


id: GO:0001968
name: fibronectin binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with a fibronectin, a group of related adhesive glycoproteins of high molecular weight found on the surface of animal cells, connective tissue matrices, and in extracellular fluids." [GOC:hjd]


id: GO:0001969
name: regulation of activation of membrane attack complex
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of the activation of the membrane attack complex components of the complement cascade." [GOC:hjd]


id: GO:0001970
name: positive regulation of activation of membrane attack complex
namespace: biological_process
def:
  "Any process that activates, maintains or increases the frequency, rate or extent of the activation of the membrane attack complex components of the complement cascade." [GOC:hjd]


id: GO:0001971
name: negative regulation of activation of membrane attack complex
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of the activation of the membrane attack complex components of the complement cascade." [GOC:hjd]


id: GO:0001972
name: retinoic acid binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with retinoic acid, 3,7-dimethyl-9-(2,6,-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoic acid." [GOC:hjd]


id: GO:0001973
name: adenosine receptor signaling pathway
namespace: biological_process
def:
  "The series of molecular signals generated as a consequence of a receptor binding to extracellular adenosine and transmitting the signal to a heterotrimeric G-protein complex to initiate a change in cell activity." [GOC:dph]


id: GO:0001975
name: response to amphetamine
namespace: biological_process
def:
  "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amphetamine stimulus. Amphetamines consist of a group of compounds related to alpha-methylphenethylamine." [CHEBI:2679, GOC:dph, GOC:ef]


id: GO:0001976
name: neurological system process involved in regulation of systemic arterial blood pressure
namespace: biological_process
def:
  "The regulation of blood pressure mediated by detection of stimuli and a neurological response." [GOC:mtg_cardio, ISBN:0721643949]


id: GO:0001977
name: renal system process involved in regulation of blood volume
namespace: biological_process
def:
  "A slow mechanism of blood pressure regulation that responds to changes in pressure resulting from fluid and salt intake by modulating the quantity of blood in the circulatory system." [GOC:dph, GOC:tb, ISBN:0721643949]


id: GO:0001978
name: regulation of systemic arterial blood pressure by carotid sinus baroreceptor feedback
namespace: biological_process
def:
  "The process that modulates blood pressure by sensing the amount of stretch occurring in large arteries and responding to the input via central nervous system control." [GOC:dph, GOC:tb, ISBN:0721643949]


id: GO:0001979
name: regulation of systemic arterial blood pressure by chemoreceptor signaling
namespace: biological_process
def:
  "The process that modulates blood pressure by the action of chemoreceptors found in the carotid and aortic bodies and their resultant modulation of the vasomotor center. Chemoreceptors respond to oxygen, carbon dioxide and hydrogen ions." [GOC:dph, GOC:tb, ISBN:0721643949]


id: GO:0001980
name: regulation of systemic arterial blood pressure by ischemic conditions
namespace: biological_process
def:
  "The process that modulates blood pressure by the detection of carbon dioxide levels in the brain stem. Increased levels activate the sympathetic vasoconstrictor mechanism increasing the force with which blood flows through the circulatory system." [GOC:dph, GOC:tb, ISBN:0721643949]


id: GO:0001981
name: baroreceptor detection of arterial stretch
namespace: biological_process
def:
  "The series of events by which the change in diameter of an artery is detected and converted to a molecular signal." [GOC:mtg_cardio, ISBN:0721643949]


id: GO:0001982
name: baroreceptor response to decreased systemic arterial blood pressure
namespace: biological_process
def:
  "The lowering of the number of nerve impulses from baroreceptors as a result of decreased stretch of an artery that results in an increased in sympathetic nerve impulses to peripheral blood vessels." [GOC:dph, GOC:mtg_cardio, ISBN:0323031951, ISBN:0721643949]


id: GO:0001983
name: baroreceptor response to increased systemic arterial blood pressure
namespace: biological_process
def:
  "The increase in nerve impulses from baroreceptors as a result of increased pressure on an artery that results in an inhibition of sympathetic nerve impulses to peripheral blood vessels." [GOC:mtg_cardio, ISBN:0323031951, ISBN:0721643949]


id: GO:0001984
namespace: biological_process
name:
  vasodilation of artery involved in baroreceptor response to increased systemic arterial blood pressure

def:
  "An increase in the internal diameter of an artery, triggered by vasomotor suppression, during the chemoreceptor response to decreased blood pressure." [ISBN:0721643949]


id: GO:0001985
namespace: biological_process
name:
  negative regulation of heart rate involved in baroreceptor response to increased systemic arterial blood pressure

def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of heart contraction as a result of the baroreceptor response to increased blood pressure." [ISBN:0721643949]


id: GO:0001986
namespace: biological_process
name:
  negative regulation of the force of heart contraction involved in baroreceptor response to increased systemic arterial blood pressure

def:
  "Any process that decreases the force with which the cardiac muscles of the heart pump blood through the circulatory system as a result of the baroreceptor response to increased blood pressure." [GOC:mtg_cardio, ISBN:0721643949]


id: GO:0001987
namespace: biological_process
name:
  vasoconstriction of artery involved in baroreceptor response to lowering of systemic arterial blood pressure

def:
  "A process that is triggered by vasomotor excitation and results in a decrease in the diameter of an artery during the baroreceptor response to decreased blood pressure." [ISBN:0721643949]


id: GO:0001988
namespace: biological_process
name:
  positive regulation of heart rate involved in baroreceptor response to decreased systemic arterial blood pressure

def:
  "Any process that activates, maintains or increases the frequency, rate or extent of heart contraction as a result of the baroreceptor response to decreased blood pressure." [ISBN:0721643949]


id: GO:0001989
namespace: biological_process
name:
  positive regulation of the force of heart contraction involved in baroreceptor response to decreased systemic arterial blood pressure

def:
  "Any process that increases the force with which the cardiac muscles of the heart pump blood through the circulatory system as part of the baroreceptor response to decreased blood pressure." [ISBN:0721643949]


id: GO:0001990
name: regulation of systemic arterial blood pressure by hormone
namespace: biological_process
def:
  "The process in which hormones modulate the force with which blood passes through the circulatory system. A hormone is one of a group of substances formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells, in the same organism, upon which they have a specific regulatory action." [GOC:mtg_cardio, ISBN:0721643949]


id: GO:0001991
name: regulation of systemic arterial blood pressure by circulatory renin-angiotensin
namespace: biological_process
def:
  "The process in which angiotensinogen metabolites in the bloodstream modulate the force with which blood passes through the circulatory system. The process begins when renin is released and cleaves angiotensinogen." [ISBN:0721643949]


id: GO:0001992
name: regulation of systemic arterial blood pressure by vasopressin
namespace: biological_process
def:
  "The regulation of blood pressure mediated by the signaling molecule vasopressin. Vasopressin is produced in the hypothalamus, and affects vasoconstriction, and renal water transport." [GOC:mtg_cardio, ISBN:0721643949]


id: GO:0001993
name: regulation of systemic arterial blood pressure by norepinephrine-epinephrine
namespace: biological_process
def:
  "The process in which the secretion of norepinephrine or epinephrine into the bloodstream modulates the force with which blood passes through the circulatory system." [ISBN:0721643949]


id: GO:0001994
namespace: biological_process
name:
  norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure

def:
  "A process that results in a decrease in the diameter of an artery during the norepinephrine-epinephrine response to decreased blood pressure." [GOC:mtg_cardio, ISBN:0721643949]


id: GO:0001995
name: norepinephrine-epinephrine catabolic process in blood stream
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the breakdown of norepinephrine or epinephrine in the bloodstream." [GOC:hjd]


id: GO:0001996
name: positive regulation of heart rate by epinephrine-norepinephrine
namespace: biological_process
def:
  "The process in which the presence of epinephrine or norepinephrine in the bloodstream activates, maintains or increases the rate of heart contraction." [GOC:dph]


id: GO:0001997
name: positive regulation of the force of heart contraction by epinephrine-norepinephrine
namespace: biological_process
def:
  "Any process that increases the force with which the cardiac muscles of the heart pump blood through the circulatory system as a result of the presence of epinephrine or norepinephrine in the bloodstream or released from the nerve endings." [GOC:dph, GOC:mtg_cardio]


id: GO:0001998
name: angiotensin mediated vasoconstriction involved in regulation of systemic arterial blood pressure
namespace: biological_process
def:
  "The decrease in blood vessel diameter as a result of the release of angiotensin into the blood stream." [GOC:mtg_cardio, ISBN:0721643949]


id: GO:0001999
namespace: biological_process
def: "The physiological response of the kidneys to a decrease in blood flow." [GOC:dph]
name:
  renal response to blood flow involved in circulatory renin-angiotensin regulation of systemic arterial blood pressure


id: GO:0002000
name: detection of renal blood flow
namespace: biological_process
def:
  "The process in which the juxtaglomerular cells of the kidneys receive information about the amount of blood flowing through the arterioles and converts the information to a molecular signal." [ISBN:0721643949]


id: GO:0002002
name: regulation of angiotensin levels in blood
namespace: biological_process
def:
  "The process that modulates the level of angiotensin in the blood by balancing the maturation of renin substrate to mature angiotensin and the catabolism of mature angiotensin." [GOC:dph]


id: GO:0002003
name: angiotensin maturation
namespace: biological_process
def:
  "The process leading to the attainment of the full functional capacity of angiotensin by conversion of renin substrate into mature angiotensin in the blood." [ISBN:0721643949]


id: GO:0002004
name: secretion of vasopressin involved in fast regulation of systemic arterial blood pressure
namespace: biological_process
def:
  "The regulated release of the hormone vasopressin into the blood stream by the hypothalamus and pituitary gland contributing to fast regulation of blood pressure." [ISBN:0721643949]


id: GO:0002005
name: angiotensin catabolic process in blood
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the breakdown of angiotensin in the blood." [ISBN:0721643949]


id: GO:0002006
name: vasoconstriction by vasopressin involved in systemic arterial blood pressure control
namespace: biological_process
def:
  "The decrease in blood vessel diameter as a result of the release of vasopressin into the blood stream." [GOC:dph, GOC:mtg_cardio, GOC:tb, ISBN:0721643949]


id: GO:0002007
name: detection of hypoxic conditions in blood by chemoreceptor signaling
namespace: biological_process
def:
  "The process in which information about a lack of oxygen are received and are converted to a molecular signal by chemoreceptors in the carotid bodies and the aortic bodies." [GOC:dph]


id: GO:0002008
name: excitation of vasomotor center by chemoreceptor signaling
namespace: biological_process
def:
  "The process in which the molecular signal from the carotid and aortic bodies is relayed to the vasomotor center, causing it to signal an increase arterial pressure." [GOC:dph]


id: GO:0002009
name: morphogenesis of an epithelium
namespace: biological_process
def:
  "The process in which the anatomical structures of epithelia are generated and organized. An epithelium consists of closely packed cells arranged in one or more layers, that covers the outer surfaces of the body or lines any internal cavity or tube." [GOC:dph, GOC:jl, GOC:tb, ISBN:0198506732]


id: GO:0002010
name: excitation of vasomotor center by baroreceptor signaling
namespace: biological_process
def:
  "The process in which the molecular signal from the arterial baroreceptors is relayed to the vasomotor center causing it to signal increase arterial pressure." [GOC:dph]


id: GO:0002011
name: morphogenesis of an epithelial sheet
namespace: biological_process
def:
  "The process in which the anatomical structures of an epithelial sheet are generated and organized. An epithelial sheet is a flat surface consisting of closely packed epithelial cells." [GOC:jl]


id: GO:0002012
namespace: biological_process
name:
  vasoconstriction of artery involved in chemoreceptor response to lowering of systemic arterial blood pressure

def:
  "A process that is triggered by vasomotor excitation and results in a decrease in the diameter of an artery during the chemoreceptor response to decreased blood pressure." [GOC:dph, GOC:mtg_cardio]


id: GO:0002013
name: detection of carbon dioxide by vasomotor center
namespace: biological_process
def:
  "The process by a carbon dioxide stimulus is received and converted to a molecular signal by the vasomotor center of the central nervous system." [ISBN:0721643949]


id: GO:0002014
namespace: biological_process
name:
  vasoconstriction of artery involved in ischemic response to lowering of systemic arterial blood pressure

def:
  "The vasoconstriction that is triggered by vasomotor excitation resulting from the detection of high carbon dioxide levels in the vasomotor center of the central nervous system." [GOC:mtg_cardio, ISBN:0721643949]


id: GO:0002015
name: regulation of systemic arterial blood pressure by atrial baroreceptor feedback
namespace: biological_process
def:
  "A process that controls blood pressure by sensing the amount of stretch occurring in the atria." [GOC:dph, GOC:tb]


id: GO:0002016
name: regulation of blood volume by renin-angiotensin
namespace: biological_process
def:
  "The process in which the renin-angiotensin system controls the rate of fluid intake and output into the blood." [GOC:dph, GOC:mtg_cardio, GOC:tb, ISBN:0721643949]


id: GO:0002017
name: regulation of blood volume by renal aldosterone
namespace: biological_process
def:
  "The process in which the hormone aldosterone decreases the rate of diuresis and natriuresis resulting in increased blood volume." [GOC:dph, GOC:tb, ISBN:0721643949]


id: GO:0002018
name: renin-angiotensin regulation of aldosterone production
namespace: biological_process
def:
  "The process in which an increase in active angiotensin stimulates the adrenal cortices to secrete aldosterone." [ISBN:0721643949]


id: GO:0002019
name: regulation of renal output by angiotensin
namespace: biological_process
def:
  "The process in which angiotensin directly modulates the rate of urine output by the kidney." [GOC:dph, GOC:mtg_cardio, GOC:tb, ISBN:0721643949]


id: GO:0002021
name: response to dietary excess
namespace: biological_process
def:
  "The physiological process in which dietary excess is sensed by the central nervous system, resulting in a reduction in food intake and increased energy expenditure." [GOC:pg, GOC:pr, PMID:12161655]


id: GO:0002023
name: reduction of food intake in response to dietary excess
namespace: biological_process
def:
  "An eating behavior process whereby detection of a dietary excess results in a decrease in intake of nutrients." [GOC:pg, GOC:pr, PMID:12161655, PMID:12840200]


id: GO:0002024
name: diet induced thermogenesis
namespace: biological_process
def:
  "The process that results in increased metabolic rate in tissues of an organism. It is triggered by the detection of dietary excess. This process is achieved via signalling in the sympathetic nervous system." [PMID:12161655]


id: GO:0002025
namespace: biological_process
name:
  vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressure

def:
  "A process that results in an increase in the diameter of an artery during the norepinephrine-epinephrine response to blood pressure change." [GOC:mtg_cardio, PMID:10358008]


id: GO:0002026
name: regulation of the force of heart contraction
namespace: biological_process
def:
  "Any process that modulates the extent of heart contraction, changing the force with which blood is propelled." [GOC:dph, GOC:tb, PMID:10358008]


id: GO:0002027
name: regulation of heart rate
namespace: biological_process
def:
  "Any process that modulates the frequency or rate of heart contraction." [GOC:dph, GOC:tb, PMID:10358008]


id: GO:0002028
name: regulation of sodium ion transport
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of the directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:dph]


id: GO:0002029
name: desensitization of G-protein coupled receptor protein signaling pathway
namespace: biological_process
def:
  "The process that stops, prevents, or reduces the frequency, rate or extent of G-protein coupled receptor protein signaling pathway activity after prolonged stimulation with an agonist of the pathway." [PMID:8396717]


id: GO:0002030
name: inhibitory G-protein coupled receptor phosphorylation
namespace: biological_process
def:
  "The process that inhibits the signaling function of a G-protein coupled receptor by addition of a phosphate group to its third intracellular loop consensus site." [PMID:8396717]


id: GO:0002031
name: G-protein coupled receptor internalization
namespace: biological_process
def:
  "The process that results in the uptake of a G-protein coupled receptor into an endocytic vesicle." [PMID:8396717]


id: GO:0002032
name: desensitization of G-protein coupled receptor protein signaling pathway by arrestin
namespace: biological_process
def:
  "The process that inhibits the signaling function of a G-protein coupled receptor by uncoupling the receptor from its downstream G proteins." [GOC:dph, GOC:tb, PMID:8396717]


id: GO:0002033
name: vasodilation by angiotensin involved in regulation of systemic arterial blood pressure
namespace: biological_process
def:
  "The process that increases the size of a blood vessel via the renin-angiotensin system." [ISBN:0323031951, PMID:10425188]


id: GO:0002034
name: regulation of blood vessel size by renin-angiotensin
namespace: biological_process
def:
  "The process in which the diameter of a blood vessel is changed due to activity of the renin-angiotensin system." [GOC:dph, GOC:tb]


id: GO:0002035
name: brain renin-angiotensin system
namespace: biological_process
def:
  "The process in which an angiotensin-mediated signaling system present in the brain regulates the force with which blood passes through the circulatory system." [PMID:2909574]


id: GO:0002037
name: negative regulation of L-glutamate transport
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of L-glutamate transport." [GOC:hjd]


id: GO:0002038
name: positive regulation of L-glutamate transport
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of L-glutamate transport." [GOC:hjd]


id: GO:0002040
name: sprouting angiogenesis
namespace: biological_process
def:
  "The extension of new blood vessels from existing capillaries into avascular tissues resulting from the proliferation of blood vessel endothelial cells." [PMID:16391003]


id: GO:0002041
name: intussusceptive angiogenesis
namespace: biological_process
def:
  "The formation of new blood vessels as a result of the insertion and extension of lumenal tissue pillars." [PMID:16391003]


id: GO:0002042
name: cell migration involved in sprouting angiogenesis
namespace: biological_process
def:
  "The orderly movement of endothelial cells into the extracellular matrix in order to form new blood vessels involved in sprouting angiogenesis." [PMID:16391003]


id: GO:0002043
name: blood vessel endothelial cell proliferation involved in sprouting angiogenesis
namespace: biological_process
def:
  "The multiplication or reproduction of blood vessel endothelial cells, resulting in the expansion of a cell population contributing to sprouting angiogenesis." [GOC:dph, GOC:tb, PMID:16391003]


id: GO:0002044
name: blood vessel endothelial cell migration involved in intussusceptive angiogenesis
namespace: biological_process
def:
  "The orderly movement of endothelial cells into the extracellular matrix in order to form new blood vessels during intussusceptive angiogenesis." [PMID:16391003]


id: GO:0002045
name: regulation of cell adhesion involved in intussusceptive angiogenesis
namespace: biological_process
def:
  "The process that modulates the frequency, rate or extent of attachment of a blood vessel endothelial cell to another cell or to the extracellular matrix involved in intussusceptive angiogenesis." [PMID:16391003]


id: GO:0002046
name: opsin binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with an opsin, any of a group of hydrophobic, integral membrane glycoproteins located primarily in the disc membrane of rods or cones, involved in photoreception." [GOC:hjd]


id: GO:0002047
name: phenazine biosynthetic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of a phenazine antibiotic, a polycyclic pyrazine with two nitrogen atoms in the ring." [GOC:dph]


id: GO:0002049
name: pyoverdine biosynthetic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of the siderochrome pyoverdine." [PMID:15317763]


id: GO:0002050
name: pyoverdine catabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the breakdown of the siderochrome pyoverdine." [PMID:15317763]


id: GO:0002051
name: osteoblast fate commitment
namespace: biological_process
def:
  "The commitment of mesenchymal cells to the specific cell fate of an osteoblast. An osteoblast is a bone-forming cell which secretes an extracellular matrix. Hydroxyapatite crystals are then deposited into the matrix to form bone." [GOC:dph]


id: GO:0002053
name: positive regulation of mesenchymal cell proliferation
namespace: biological_process
def:
  "The process of activating or increasing the rate or extent of mesenchymal cell proliferation. Mesenchymal cells are loosely organized embryonic cells." [GOC:dph]


id: GO:0002054
name: nucleobase binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with a nucleobase, any of a class of pyrmidines or purines, organic nitrogenous bases." [GOC:hjd]


id: GO:0002060
name: purine nucleobase binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with a purine nucleobase, an organic nitrogenous base with a purine skeleton." [CHEBI:26386, GOC:hjd]


id: GO:0002061
name: pyrimidine nucleobase binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with a pyrimidine nucleobase, an organic nitrogenous base with a pyrimidine skeleton." [CHEBI:26432, GOC:hjd]


id: GO:0002062
name: chondrocyte differentiation
namespace: biological_process
def:
  "The process in which a chondroblast acquires specialized structural and/or functional features of a chondrocyte. A chondrocyte is a polymorphic cell that forms cartilage." [GOC:dph]


id: GO:0002063
name: chondrocyte development
namespace: biological_process
def:
  "The process whose specific outcome is the progression of a chondrocyte over time, from its commitment to its mature state. Chondrocyte development does not include the steps involved in committing a chondroblast to a chondrocyte fate." [GOC:dph]


id: GO:0002064
name: epithelial cell development
namespace: biological_process
def:
  "The process whose specific outcome is the progression of an epithelial cell over time, from its formation to the mature structure. An epithelial cell is a cell usually found in a two-dimensional sheet with a free surface." [GOC:dph]


id: GO:0002065
name: columnar/cuboidal epithelial cell differentiation
namespace: biological_process
def:
  "The process in which a relatively unspecialized cell acquires specialized features of a columnar/cuboidal epithelial cell. A columnar/cuboidal epithelial cell is a cell usually found in a two dimensional sheet with a free surface. Columnar/cuboidal epithelial cells take on the shape of a column or cube." [GOC:dph]


id: GO:0002066
name: columnar/cuboidal epithelial cell development
namespace: biological_process
def:
  "The process whose specific outcome is the progression of a columnar/cuboidal epithelial cell over time, from its formation to the mature structure. A columnar/cuboidal epithelial cell is a cell usually found in a two dimensional sheet with a free surface. Columnar/cuboidal epithelial cells take on the shape of a column or cube." [GOC:dph]


id: GO:0002067
name: glandular epithelial cell differentiation
namespace: biological_process
def:
  "The process in which a relatively unspecialized cell acquires specialized features of a glandular epithelial cell. A glandular epithelial cell is a columnar/cuboidal epithelial cell found in a two dimensional sheet with a free surface exposed to the lumen of a gland." [GOC:dph]


id: GO:0002068
name: glandular epithelial cell development
namespace: biological_process
def:
  "The process whose specific outcome is the progression of a glandular epithelial cell over time, from its formation to the mature structure. A glandular epithelial cell is a columnar/cuboidal epithelial cell is a cell found in a two dimensional sheet with a free surface exposed to the lumen of a gland." [GOC:dph]


id: GO:0002069
name: columnar/cuboidal epithelial cell maturation
namespace: biological_process
def:
  "The developmental process, independent of morphogenetic (shape) change, that is required for a columna/cuboidal epithelial cell to attain its fully functional state. A columnar/cuboidal epithelial cell is a cell usually found in a two dimensional sheet with a free surface. Columnar/cuboidal epithelial cells take on the shape of a column or cube." [GOC:dph]


id: GO:0002070
name: epithelial cell maturation
namespace: biological_process
def:
  "The developmental process, independent of morphogenetic (shape) change, that is required for an epithelial cell to attain its fully functional state. An epithelial cell is a cell usually found in a two-dimensional sheet with a free surface." [GOC:dph]


id: GO:0002071
name: glandular epithelial cell maturation
namespace: biological_process
def:
  "The developmental process, independent of morphogenetic (shape) change, that is required for a glandular epithelial cell to attain its fully functional state. A glandular epithelial cell is a columnar/cuboidal epithelial cell is a cell found in a two dimensional sheet with a free surface exposed to the lumen of a gland." [GOC:dph]


id: GO:0002072
name: optic cup morphogenesis involved in camera-type eye development
namespace: biological_process
def:
  "The invagination of the optic vesicle to form two-walled indentations, the optic cups, that will go on to form the retina. This process begins with the optic vesicle becoming a two-walled structure and its subsequent shape changes. It does not include the fate commitment of cells to become the pigmented retina and the neural retina. An example of this process is found in Mus musculus." [GOC:dph, GOC:mtg_sensu, GOC:sdb_2009, GOC:tb, ISBN:0878932437]


id: GO:0002074
name: extraocular skeletal muscle development
namespace: biological_process
def:
  "The process whose specific outcome is the progression of the extraocular skeletal muscle over time, from its formation to the mature structure. The extraocular muscle is derived from cranial mesoderm and controls eye movements. The muscle begins its development with the differentiation of the muscle cells and ends with the mature muscle. An example of this process is found in Mus musculus." [GOC:dph, GOC:mtg_muscle, GOC:mtg_sensu, MA:0001271, PMID:16638982]


id: GO:0002075
name: somitomeric trunk muscle development
namespace: biological_process
def:
  "The process whose specific outcome is the progression of the somitomeric trunk muscle over time, from its formation to the mature structure. The somitomeric trunk muscle is derived from somitomeric mesoderm. The muscle begins its development with the differentiation of the muscle cells and ends with the mature muscle. An example of this process is found in Mus musculus." [GOC:dph, PMID:16638982]


id: GO:0002076
name: osteoblast development
namespace: biological_process
def:
  "The process whose specific outcome is the progression of an osteoblast over time, from its formation to the mature structure. Osteoblast development does not include the steps involved in committing a cranial neural crest cell or an osteoprogenitor cell to an osteoblast fate. An osteoblast is a cell that gives rise to bone." [GOC:dph]


id: GO:0002077
name: acrosome matrix dispersal
namespace: biological_process
def:
  "The proteolytic digestion of components in the acrosomal matrix that allows for their release into the egg. The dispersal of the components allows for the inner acrosomal membrane to interact with the egg." [GOC:dph, PMID:3886029]


id: GO:0002078
name: membrane fusion involved in acrosome reaction
namespace: biological_process
def:
  "The fusion of the plasma membrane of the sperm with the outer acrosomal membrane." [GOC:dph, PMID:3886029]


id: GO:0002079
name: inner acrosomal membrane
namespace: cellular_component
def:
  "The acrosomal membrane region that underlies the acrosomal vesicle and is located toward the sperm nucleus. This region is responsible for molecular interactions allowing the sperm to penetrate the zona pellucida and fuses with the egg plasma membrane." [GOC:dph, PMID:3899643, PMID:8936405]


id: GO:0002080
name: acrosomal membrane
namespace: cellular_component
def:
  "The membrane that surrounds the acrosomal lumen. The acrosome is a special type of lysosome in the head of a spermatozoon that contains acid hydrolases and is concerned with the breakdown of the outer membrane of the ovum during fertilization." [GOC:dph]


id: GO:0002081
name: outer acrosomal membrane
namespace: cellular_component
def:
  "The acrosomal membrane region that underlies the plasma membrane of the sperm. This membrane fuses with the sperm plasma membrane as part of the acrosome reaction." [GOC:dph, PMID:8936405]


id: GO:0002082
name: regulation of oxidative phosphorylation
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the phosphorylation of ADP to ATP that accompanies the oxidation of a metabolite through the operation of the respiratory chain. Oxidation of compounds establishes a proton gradient across the membrane, providing the energy for ATP synthesis." [GOC:dph]


id: GO:0002083
name: 4-hydroxybenzoate decaprenyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: all-trans-decaprenyl diphosphate + 4-hydroxybenzoate = 3-decaprenyl-4-hydroxybenzoate + diphosphate." [MetaCyc:RXN-9230]


id: GO:0002085
name: inhibition of neuroepithelial cell differentiation
namespace: biological_process
def:
  "Any process that prevents the activation of neuroepithelial cell differentiation. Neuroepithelial cell differentiation is the process in which epiblast cells acquire specialized features of neuroepithelial cells." [GOC:dph, PMID:16678814]


id: GO:0002086
name: diaphragm contraction
namespace: biological_process
def:
  "A process in which force is generated within involuntary skeletal muscle tissue, resulting in a change in muscle geometry. This process occurs in the diaphragm. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The diaphragm is a striated muscle that is necessary for the process of respiratory gaseous exchange." [GOC:dph, GOC:mtg_muscle, PMID:12458206]


id: GO:0002087
name: regulation of respiratory gaseous exchange by neurological system process
namespace: biological_process
def:
  "A process carried out by the nervous system that is required for the proper control of respiratory gaseous exchange. This process occurs in the respiratory center of the brain in vertebrates." [GOC:dph, GOC:tb, PMID:12458206]


id: GO:0002088
name: lens development in camera-type eye
namespace: biological_process
def:
  "The process whose specific outcome is the progression of the lens over time, from its formation to the mature structure. The lens is a transparent structure in the eye through which light is focused onto the retina. An example of this process is found in Mus musculus." [GOC:dph, ISBN:0582064333]


id: GO:0002089
name: lens morphogenesis in camera-type eye
namespace: biological_process
def:
  "The process in which the anatomical structures of the lens are generated and organized. The lens is a transparent structure in the eye through which light is focused onto the retina. An example of this process is found in Mus musculus." [GOC:dph, GOC:mtg_sensu]


id: GO:0002091
name: negative regulation of receptor internalization
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of receptor internalization." [GOC:hjd]


id: GO:0002092
name: positive regulation of receptor internalization
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of receptor internalization." [GOC:hjd]


id: GO:0002094
name: polyprenyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the transfer of multiple prenyl groups from one compound (donor) to another (acceptor)." [GOC:hjd]


id: GO:0002095
name: caveolar macromolecular signaling complex
namespace: cellular_component
def:
  "A complex composed of proteins required for beta adrenergic receptor activation of protein kinase A. It includes the Cav 12. subunit of L-type calcium channel, protein kinase A regulatory subunit 2(PKAR2), adenyl cyclase, beta-adrenergic receptor, G-alpha-S, protein phosphatase 2A (PP2A) and caveolin 3 (CAV3)." [PMID:16648270]


id: GO:0002096
name: polkadots
namespace: cellular_component
def:
  "A punctate, filamentous structure composed of Bcl10 that appears in the cytoplasm of T-cells shortly after T-cell receptor stimulation. Polkadots stands for Punctate Oligomeric Killing and Activating DOmains Transducing Signals." [PMID:14724296, PMID:16495340]


id: GO:0002097
name: tRNA wobble base modification
namespace: biological_process
def:
  "The process in which the nucleotide at position 34 in the anticodon of a tRNA is post-transcriptionally modified." [GOC:hjd, ISBN:155581073X]


id: GO:0002098
name: tRNA wobble uridine modification
namespace: biological_process
def:
  "The process in which a uridine in position 34 of a tRNA is post-transcriptionally modified." [GOC:hjd, ISBN:155581073X]


id: GO:0002099
name: tRNA wobble guanine modification
namespace: biological_process
def:
  "The process in which a guanine in t position 34 of a tRNA is post-transcriptionally modified." [GOC:hjd, ISBN:155581073X]


id: GO:0002100
name: tRNA wobble adenosine to inosine editing
namespace: biological_process
def:
  "The process in which an adenosine in position 34 of a tRNA is post-transcriptionally converted to inosine." [GOC:hjd, ISBN:155581073X]


id: GO:0002101
name: tRNA wobble cytosine modification
namespace: biological_process
def:
  "The process in which a cytosine in position 34 of a tRNA is post-transcriptionally modified." [GOC:hjd, ISBN:155581073X]


id: GO:0002102
name: podosome
namespace: cellular_component
def:
  "An actin-rich adhesion structure characterized by formation upon cell substrate contact and localization at the substrate-attached part of the cell, contain an F-actin-rich core surrounded by a ring structure containing proteins such as vinculin and talin, and have a diameter of 0.5 mm." [PMID:12837608, PMID:15890982]


id: GO:0002103
name: endonucleolytic cleavage of tetracistronic rRNA transcript (SSU-rRNA, LSU-rRNA, 4.5S-rRNA, 5S-rRNA)
namespace: biological_process
def:
  "Endonucleolytic cleavage of a pre-rRNA molecule originally produced as a tetracistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, Large Subunit (LSU) the 4.5S rRNA, and the 5S rRNA in that order from 5' to 3' along the primary transcript. Primary ribosomal RNA transcripts with four genes, in this order, are produced in the chloroplasts of vascular plants. Note that the use of the word tetracistronic refers only to the number of mature rRNA molecules which will be produced from the primary transcript and ignores tRNAs that may also be present within the primary transcript." [GOC:curators]


id: GO:0002104
namespace: biological_process
name:
  endonucleolytic cleaveage between 4.5S rRNA and 5S rRNA of tetracistronic rRNA transcript (SSU-rRNA, LSU-rRNA, 4.5S-rRNA, 5S-rRNA)

def:
  "Endonucleolytic cleavage between the 5S rRNA and the 4.5S rRNA of an rRNA molecule originally produced as a tetracistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, Large Subunit (LSU) the 4.5S rRNA, and the 5S rRNA in that order from 5' to 3' along the primary transcript. Note that the use of the word tetracistronic refers only to the number of mature rRNA molecules which will be produced from the primary transcript and ignores tRNAs that may also be present within the primary transcript." [GOC:curators]


id: GO:0002105
namespace: biological_process
name:
  endonucleolytic cleaveage between LSU-rRNA and 4.5S rRNA of tetracistronic rRNA transcript (SSU-rRNA, LSU-rRNA, 4.5S-rRNA, 5S-rRNA)

def:
  "Endonucleolytic cleavage between the LSU-rRNA and the 4.5S rRNA of an rRNA molecule originally produced as a tetracistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, Large Subunit (LSU) the 4.5S rRNA, and the 5S rRNA in that order from 5' to 3' along the primary transcript. Note that the use of the word tetracistronic refers only to the number of mature rRNA molecules which will be produced from the primary transcript and ignores tRNAs that may also be present within the primary transcript." [GOC:curators]


id: GO:0002106
namespace: biological_process
name:
  endonucleolytic cleaveage between SSU-rRNA and LSU-rRNA of tetracistronic rRNA transcript (SSU-rRNA, LSU-rRNA, 4.5S-rRNA, 5S-rRNA)

def:
  "Endonucleolytic cleavages between the SSU-rRNA and the LSU-rRNA of an rRNA molecule originally produced as a tetracistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, Large Subunit (LSU) the 4.5S rRNA, and the 5S rRNA in that order from 5' to 3' along the primary transcript. These cleavages liberate tRNAs from the polycistronic transcript as well as separating the SSU and LSU containing transcript. Note that the use of the word tetracistronic refers only to the number of mature rRNA molecules which will be produced from the primary transcript and ignores tRNAs that may also be present within the primary transcript." [GOC:curators]


id: GO:0002107
name: generation of mature 3'-end of 5S rRNA generated by RNA polymerase III
namespace: biological_process
def:
  "The removal of extra uridine residues from the 3' end of a 5S pre-rRNA generated by transcription by RNA polymerase III to generate the mature 3'-end." [GOC:hjd, PMID:16387655, PMID:1748637, PMID:1902221, PMID:8389357]


id: GO:0002108
name: maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, LSU-rRNA,5S)
namespace: biological_process
def:
  "Any process involved in the maturation of a precursor Large SubUnit (LSU) ribosomal RNA (rRNA) molecule into a mature LSU-rRNA molecule from the pre-rRNA molecule originally produced as a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, Large Subunit (LSU) the 5S rRNA in that order from 5' to 3' along the primary transcript." [GOC:curators]


id: GO:0002109
name: maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, LSU-rRNA,5S)
namespace: biological_process
def:
  "Any process involved in the maturation of a precursor Small SubUnit (SSU) ribosomal RNA (rRNA) molecule into a mature SSU-rRNA molecule from the pre-rRNA molecule originally produced as a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, Large Subunit (LSU) the 5S rRNA in that order from 5' to 3' along the primary transcript." [GOC:curators]


id: GO:0002110
name: cotranscriptional mitochondrial rRNA nucleotide insertion
namespace: biological_process
def:
  "The insertion of one or two non-coded nucleotides during the transcription of a mitochondrial rRNA. Such additions are known to occur in myxomycetes such as Physarum, Didymium, and Stemonitis." [GOC:curators, ISBN:1555811337, PMID:8306965]


id: GO:0002111
name: BRCA2-BRAF35 complex
namespace: cellular_component
def:
  "A heterodimeric complex of BRCA2 and BRAF35 (BRCA2-associated factor 35). The BRCA2-BRAF35 complex is often associated with condensed chromatin during mitosis." [GOC:hjd, PMID:11207365]


id: GO:0002114
name: interleukin-33 receptor activity
namespace: molecular_function
def:
  "Combining with interleukin-33 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:hjd, GOC:signaling]


id: GO:0002115
name: store-operated calcium entry
namespace: biological_process
def:
  "A calcium ion entry mechanism in the plasma membrane activated by the depletion of calcium ion from the internal calcium ion store in the endoplasmic reticulum." [GOC:hjd, PMID:11120592, PMID:17956991]


id: GO:0002116
name: semaphorin receptor complex
namespace: cellular_component
def:
  "A stable binary complex of a neurophilin and a plexin, together forming a functional semaphorin receptor." [GOC:hjd, PMID:10934324, PMID:12367632, PMID:12613544]


id: GO:0002117
name: amphibian larval development
namespace: biological_process
def:
  "The process whose specific outcome is the progression of the amphibian larva over time, from its formation to the mature structure. Amphibian larvae, sometimes called pollywogs or tadpoles, hatch from eggs and begin to grow limbs and other adult physical features at various times, depending on the species, before they metamorphose into the adult form." [GOC:bf, GOC:go_curators, http://www.livingunderworld.org/biology/]


id: GO:0002118
name: aggressive behavior
namespace: biological_process
def:
  "A behavioral interaction between organisms in which one organism has the intention of inflicting physical damage on another individual." [GOC:hjd]


id: GO:0002119
name: nematode larval development
namespace: biological_process
def:
  "The process whose specific outcome is the progression of the nematode larva over time, from its formation to the mature structure. Nematode larval development begins with the newly hatched first-stage larva (L1) and ends with the end of the last larval stage (for example the fourth larval stage (L4) in C. elegans). Each stage of nematode larval development is characterized by proliferation of specific cell lineages and an increase in body size without alteration of the basic body plan. Nematode larval stages are separated by molts in which each stage-specific exoskeleton, or cuticle, is shed and replaced anew." [GOC:ems, GOC:kmv]


id: GO:0002121
name: inter-male aggressive behavior
namespace: biological_process
def:
  "Aggressive behavior based on competition between males of the same species over access to resources such as females, dominance, status, etc. and characterized by noise, threats, and is often less injurious." [GOC:hjd]


id: GO:0002124
name: territorial aggressive behavior
namespace: biological_process
def:
  "Aggressive behavior performed in defence of a fixed area against intruders, typically conspecifics." [GOC:hjd]


id: GO:0002126
name: instrumental aggressive behavior
namespace: biological_process
def:
  "Aggressive behavior directed towards obtaining some goal, considered to be a learned response to a situation." [GOC:hjd]


id: GO:0002127
name: wobble base cytosine methylation
namespace: biological_process
def:
  "The process in which the base of cytosine at position 34 in the anticodon of a tRNA is post-transcriptionally methylated at the C5 position." [GOC:hjd, ISBN:155581073X]


id: GO:0002128
name: tRNA nucleoside ribose methylation
namespace: biological_process
def:
  "The process that results in the modification of the sugar of a nucleoside in tRNA at the 2'O position." [GOC:hjd, ISBN:155581073X]


id: GO:0002129
name: wobble position guanine ribose methylation
namespace: biological_process
def:
  "The process in which the ribose of guanosine at position 34 in the anticodon of a tRNA is post-transcriptionally methylated at the 2'-O position." [GOC:hjd, ISBN:155581073X]


id: GO:0002130
name: wobble position ribose methylation
namespace: biological_process
def:
  "The process in which the ribose base of the nucleotide at position 34 in the anticodon of a tRNA is post-transcriptionally methylated at the 2'O position." [GOC:hjd, ISBN:155581073X]


id: GO:0002131
name: wobble position cytosine ribose methylation
namespace: biological_process
def:
  "The process in which the ribose of cytidine at position 34 in the anticodon of a tRNA is post-transcriptionally methylated at the 2'-O position." [GOC:hjd, ISBN:155581073X]


id: GO:0002132
name: wobble position uridine ribose methylation
namespace: biological_process
def:
  "The process in which the ribose of uridine at position 34 in the anticodon of a tRNA is post-transcriptionally methylated at the 2'-O position." [GOC:hjd, ISBN:155581073X]


id: GO:0002133
name: polycystin complex
namespace: cellular_component
def:
  "A stable heterodimeric complex composed of polycystin-1 and polycystin-2." [GOC:hjd, PMID:11901144]


id: GO:0002134
name: UTP binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with UTP, uridine 5'-triphosphate." [GOC:hjd, ISBN:0198506732]


id: GO:0002135
name: CTP binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with CTP, cytidine 5'-triphosphate." [GOC:hjd, ISBN:0124020607]


id: GO:0002136
name: wobble base lysidine biosynthesis
namespace: biological_process
def:
  "The process in which the carbonyl of cytosine at position 34 of a tRNA is post-transcriptionally replaced by lysine." [PMID:15894617]


id: GO:0002138
name: retinoic acid biosynthetic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the biosynthesis of retinoic acid, one of the three components that makes up vitamin A." [GOC:hjd]


id: GO:0002139
name: stereocilia coupling link
namespace: cellular_component
def:
  "A structure involved in coupling stereocilia to one another in sensory hair cells There are four morphologically distinct types: tip links, horizontal top connectors, shaft connectors and ankle links. Tip links and horizontal top connectors are the only inter-stereocilia links associated with mature cochlea, whereas ankle links appear during development of the auditory hair bundle." [PMID:16775142]


id: GO:0002140
name: stereocilia tip link
namespace: cellular_component
def:
  "A stereocilia link that is formed by a fine filament running more or less vertically upward from the tip of each shorter stereocilium to attach at a higher point on its adjacent taller neighbor. Tilting the bundle puts tension on the filaments, which pull on mechanically gated ion channels in the membrane of the stereocilia." [PMID:1108787]


id: GO:0002141
name: stereocilia ankle link
namespace: cellular_component
def:
  "A stereocilia coupling link that is composed of a fine filament present in developing stereocilia that couples the bases of individual stereocilia to one another. They are not present in mature stereocilia." [PMID:17567809]


id: GO:0002142
name: stereocilia ankle link complex
namespace: cellular_component
def:
  "A complex of proteins that connect growing stereocilia in developing cochlear hair cells, composed of Vlgr1, usherin, vezatin, and whirlin." [PMID:16775142]


id: GO:0002143
name: tRNA wobble position uridine thiolation
namespace: biological_process
def:
  "The process in which a uridine residue at position 34 in the anticodon of a tRNA is post-transcriptionally thiolated at the C2 position. This process involves transfer of a sulfur from cysteine to position C2 by several steps." [PMID:16871210]


id: GO:0002144
name: cytosolic tRNA wobble base thiouridylase complex
namespace: cellular_component
def:
  "A complex of two proteins involved in the thiolation of U34 in glutamate, lysine, and glutamine tRNAs of eukaryotes." [PMID:18391219]


id: GO:0002145
name: 4-amino-5-hydroxymethyl-2-methylpyrimidine diphosphatase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 4-amino-5-hydroxymethyl-2-methylpyrimidine pyrophosphate + H2O = hydroxymethylpyrimidine phosphate + phosphate + H(+)." [MetaCyc:RXN0-3543]


id: GO:0002148
name: hypochlorous acid metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving hypochlorous acid." [GOC:add, PMID:176150, PMIG:10085024]


id: GO:0002149
name: hypochlorous acid biosynthetic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of hypochlorous acid." [GOC:add, PMID:10085024, PMID:176150]


id: GO:0002151
name: G-quadruplex RNA binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with G-quadruplex RNA structures, in which groups of four guanines adopt a flat, cyclic hydrogen-bonding arrangement known as a guanine tetrad." [PMID:18294969, PMID:18568163, PMID:19330720]


id: GO:0002152
name: bile acid conjugation
namespace: biological_process
def:
  "The process in which bile acids are covalently linked to taurine or glycine." [PMID:1094911, PMID:708413]


id: GO:0002153
name: steroid receptor RNA activator RNA binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with the steroid receptor RNA activator RNA (SRA). SRA enhances steroid hormone receptor transcriptional activity as an RNA transcript by an indirect mechanism that does not involve SRA-steroid receptor binding." [GOC:vw, PMID:10199399, PMID:15180993]


id: GO:0002155
name: regulation of thyroid hormone mediated signaling pathway
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of a thyroid hormone mediated signaling pathway." [GOC:hjd]


id: GO:0002156
name: negative regulation of thyroid hormone mediated signaling pathway
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of thyroid hormone mediated signaling pathway." [GOC:hjd]


id: GO:0002157
name: positive regulation of thyroid hormone mediated signaling pathway
namespace: biological_process
def:
  "Any process that increases the frequency, rate or extent of thyroid hormone mediated signaling pathway." [GOC:hjd]


id: GO:0002158
name: osteoclast proliferation
namespace: biological_process
def:
  "The multiplication or reproduction of osteoclasts, resulting in the expansion of an osteoclast cell population. An osteoclast is a specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue, which typically differentiates from monocytes." [CL:0000092, GOC:hjd]


id: GO:0002159
name: desmosome assembly
namespace: biological_process
def:
  "A cellular process that results in the aggregation, arrangement and bonding together of a set of components to form a desmosome. A desmosome is a patch-like intercellular junction found in vertebrate tissues, consisting of parallel zones of two cell membranes, separated by an space of 25-35 nm, and having dense fibrillar plaques in the subjacent cytoplasm." [GOC:hjd, ISBN:0198506732]


id: GO:0002160
name: desmosome maintenance
namespace: biological_process
def:
  "The maintenance of a desmosome. A desmosome is a patch-like intercellular junctions found in vertebrate tissues, consisting of parallel zones of two cell membranes, separated by an interspace of 25-35 nm, and having dense fibrillar plaques in the subjacent cytoplasm." [GOC:hjd, ISBN:0198506732]


id: GO:0002162
name: dystroglycan binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with dystroglycan. Dystroglycan is glycoprotein found in non-muscle tissues as well as in muscle tissues, often in association with dystrophin. The native dystroglycan cleaved into two non-covalently associated subunits, alpha (N-terminal) and beta (C-terminal)." [GOC:hjd]


id: GO:0002164
name: larval development
namespace: biological_process
def:
  "The process whose specific outcome is the progression of the larva over time, from its formation to the mature structure. The larva is the early, immature form of an that at birth or hatching is fundamentally unlike its parent and must metamorphose before assuming the adult characters." [GOC:jid, ISBN:0877795088]


id: GO:0002165
name: instar larval or pupal development
namespace: biological_process
def:
  "The process whose specific outcome is the progression of the instar larva or pupa over time, from its formation to the mature structure. An example of this process is found in Drosophila melanogaster." [GOC:jid, GOC:mtg_sensu]


id: GO:0002167
name: VRK3/VHR/ERK complex
namespace: cellular_component
def:
  "A ternary complex consisting of VRK3, VHR (Dusp3), and ERK1 (Mapk3) existing in neuronal cells, and is involved in regulation of the ERK signaling pathway." [GOC:hjd, PMID:16845380]


id: GO:0002168
name: instar larval development
namespace: biological_process
def:
  "The process whose specific outcome is the progression of the larva over time, from its formation to the mature structure. This begins with the newly hatched first-instar larva, through its maturation to the end of the last larval stage. An example of this process is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu]


id: GO:0002169
name: 3-methylcrotonyl-CoA carboxylase complex, mitochondrial
namespace: cellular_component
def:
  "A heterodimeric complex having 3-methylcrotonyl-CoA carboxylase activity. The alpha subunit has a covalently bound biotin essential for the ATP-dependent carboxylation. The beta subunit possess carboxyltransferase activity which presumably is essential for binding to 3-methylcrotonyl-CoA." [GOC:hjd, PMID:15868465]


id: GO:0002170
name: high-affinity IgA receptor activity
namespace: molecular_function
def:
  "Combining with high affinity with an immunoglobulin of an IgA isotype via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:hjd, GOC:signaling]


id: GO:0002171
name: low-affinity IgA receptor activity
namespace: molecular_function
def:
  "Combining with low affinity with an immunoglobulin of an IgA isotype via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:hjd, GOC:signaling]


id: GO:0002172
name: high-affinity IgM receptor activity
namespace: molecular_function
def:
  "Combining with high affinity with an immunoglobulin of an IgM isotype via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:hjd, GOC:signaling]


id: GO:0002173
name: low-affinity IgM receptor activity
namespace: molecular_function
def:
  "Combining with low affinity with an immunoglobulin of an IgM isotype via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:hjd, GOC:signaling]


id: GO:0002174
name: mammary stem cell proliferation
namespace: biological_process
def:
  "The expansion of a mammary stem cell population by cell division. Mammary stem cells are a source of cells for growth of the mammary gland during puberty and gestation. These cells can give rise to both the luminal and myoepithelial cell types of the gland, and can regenerate the entire organ." [PMID:15987436]


id: GO:0002175
name: protein localization to paranode region of axon
namespace: biological_process
def:
  "A cellular protein localization process in which a protein is transported to, or maintained at, the paranode region of an axon." [PMID:18803321]


id: GO:0002176
name: male germ cell proliferation
namespace: biological_process
def:
  "The multiplication or reproduction of male germ cells, resulting in the expansion of a cell population." [GOC:hjd]


id: GO:0002177
name: manchette
namespace: cellular_component
def:
  "A conical shaped array of microtubules that completely covers the nucleus of a spermatid, thought to be involved in sperm head elongation." [PMID:15018141]


id: GO:0002179
name: homodimeric serine palmitoyltransferase complex
namespace: cellular_component
def:
  "A homodimeric complex which transfers a palmitoyl group onto serine, forming 3-dehydro-D-sphinganine." [GOC:hjd]


id: GO:0002181
name: cytoplasmic translation
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of a protein in the cytoplasm. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein." [GOC:hjd]


id: GO:0002182
name: cytoplasmic translational elongation
namespace: biological_process
def:
  "The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis in the cytoplasm." [GOC:hjd]


id: GO:0002183
name: cytoplasmic translational initiation
namespace: biological_process
def:
  "The process preceding formation of the peptide bond between the first two amino acids of a protein in the cytoplasm. This includes the formation of a complex of the ribosome, mRNA, and an initiation complex that contains the first aminoacyl-tRNA." [GOC:hjd]


id: GO:0002184
name: cytoplasmic translational termination
namespace: biological_process
def:
  "The process resulting in the release of a polypeptide chain from the ribosome in the cytoplasm, usually in response to a termination codon." [GOC:hjd]


id: GO:0002188
name: translation reinitiation
namespace: biological_process
def:
  "A gene-specific translational control mechanism where the small ribosomal subunit remains attached to the mRNA following termination of translation, then resumes scanning on the same mRNA molecule and initiates again at a downstream start site. Reinitiation depends on de novo recruitment of the ternary complex that is required to recognize the next AUG codon." [PMID:18056426, PMID:18765792]


id: GO:0002190
name: cap-independent translational initiation
namespace: biological_process
def:
  "The process where translation initiation recruits the 40S ribosomal subunits in a Cap and 5' end independent fashion before an AUG codon is encountered in an appropriate sequence context to initiate mRNA translation." [PMID:17284590]


id: GO:0002191
name: cap-dependent translational initiation
namespace: biological_process
def:
  "The process where the \"Cap structure\" (composed of a 7- methylguanosine (m7G) group and associated cap-binding proteins) located at the 5' end of an mRNA molecule, which serves as a \"molecular tag\" that marks the spot where the 40S ribosomal subunit is recruited and will then scan in a 5' to 3' direction until an AUG codon is encountered in an appropriate sequence context to initiate mRNA translation." [PMID:17284590, PMID:19604130]


id: GO:0002192
name: IRES-dependent translational initiation
namespace: biological_process
def:
  "The process where translation initiation recruits the 40S ribosomal subunits via an internal ribosome entry segment (IRES) before an AUG codon is encountered in an appropriate sequence context to initiate mRNA translation." [PMID:17284590]


id: GO:0002193
name: MAML1-RBP-Jkappa- ICN1 complex
namespace: cellular_component
def:
  "A protein complex that consists of the intracellular domain of Notch1 (ICN1), the DNA-binding transcription factor RBP-Jkappa, and the transcriptional coactivator Mastermind-like-1 (MAML1); the complex is involved in transcriptional activation in response to Notch-mediated signaling." [CORUM:2949, PMID:16510869]


id: GO:0002194
name: hepatocyte cell migration
namespace: biological_process
def:
  "The orderly movement of a hepatocyte during the development of the liver. Hepatocytes emerge from the hepatic epithelium, populating the septum transversum and lateral mesenchymal areas of the hepatic lobes." [CL:0000182, PMID:9794819]


id: GO:0002195
name: 2-methylthio-N-6-(cis-hydroxy)isopentenyl adenosine-tRNA biosynthesis
namespace: biological_process
def:
  "The chemical reactions and pathways involved in the biosynthesis of 2-methylthio-N-6-(cis-hydroxy)isopentenyl adenosine (ms2io6A), a modified nucleoside present in position 37 (adjacent to and 3' of the anticodon) of tRNAs." [UniPathway:UPA00729]


id: GO:0002198
name: obsolete S/G2 transition of mitotic cell cycle
namespace: biological_process
def:
  "OBSOLETE. The transition from a cell in the S phase to the G2 phase." [GOC:hjd, GOC:mtg_cell_cycle, PMID:15161931]


id: GO:0002199
name: zona pellucida receptor complex
namespace: cellular_component
def:
  "A multisubunit complex comprising the chaperonin-containing T-complex and several other components involved in mediating sperm-oocyte Interaction." [GOC:hjd, PMID:21880732]


id: GO:0002200
name: somatic diversification of immune receptors
namespace: biological_process
def:
  "The somatic process allowing for the production of immune receptors whose specificity is not encoded in the germline genomic sequences." [GOC:add, ISBN:0781735149, PMID:16102575, PMID:16166509]


id: GO:0002201
name: somatic diversification of DSCAM-based immune receptors
namespace: biological_process
def:
  "The somatic process that results in the generation of sequence diversity of the DSCAM-based immune receptors of insects." [GOC:add, PMID:16261174]


id: GO:0002202
name: somatic diversification of variable lymphocyte receptors of jawless fish
namespace: biological_process
def:
  "The somatic process that results in the generation of sequence diversity of the variable lymphocyte receptors (VLR) of jawless fish." [GOC:add, PMID:16373579]


id: GO:0002203
name: proteolysis by cytosolic proteases associated with antigen processing and presentation
namespace: biological_process
def:
  "The hydrolysis of a peptide bond or bonds within a protein by cytosolic resident proteases during antigen processing and presentation." [GOC:add, ISBN:0781735149, PMID:15224092, PMID:15771591]


id: GO:0002204
name: somatic recombination of immunoglobulin genes involved in immune response
namespace: biological_process
def:
  "The process in which immunoglobulin genes are formed through recombination of the germline genetic elements, also known as immunoglobulin gene segments, within a single locus following the induction of and contributing to an immune response." [GOC:add, ISBN:0781735149]


id: GO:0002205
name: somatic hypermutation of immunoglobulin genes involved in immune response
namespace: biological_process
def:
  "Mutations occurring somatically that result in amino acid changes in the rearranged V regions of immunoglobulins following the induction of and contributing to an immune response." [GOC:add, ISBN:0781735149, PMID:11205333, PMID:14991701]


id: GO:0002206
name: gene conversion of immunoglobulin genes
namespace: biological_process
def:
  "The somatic process in which immunoglobulin genes are diversified through the mechanism of gene conversion." [GOC:add, PMID:14991701]


id: GO:0002207
name: gene conversion of immunoglobulin genes involved in immune response
namespace: biological_process
def:
  "The somatic process in which immunoglobulin genes are diversified through the mechanism of gene conversion following the induction of and contributing to an immune response." [GOC:add, PMID:14991701]


id: GO:0002208
name: somatic diversification of immunoglobulins involved in immune response
namespace: biological_process
def:
  "The somatic process that results in the generation of sequence diversity of immunoglobulins after induction, and contributes to an immune response." [GOC:add, ISBN:0781735149, PMID:14991701]


id: GO:0002209
name: behavioral defense response
namespace: biological_process
def:
  "A behavioral response seeking to protect an organism from an a perceived external threat to that organism." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05]


id: GO:0002211
name: behavioral defense response to insect
namespace: biological_process
def:
  "A behavioral response seeking to protect an organism from an a perceived external threat from an insect or insects to that organism." [GOC:add]


id: GO:0002212
name: behavioral defense response to nematode
namespace: biological_process
def:
  "A behavioral response seeking to protect an organism from an a perceived external threat from a nematode or nematodes to that organism." [GOC:add, PMID:14506883]


id: GO:0002213
name: defense response to insect
namespace: biological_process
def:
  "A response to protect an organism from a directly detected or perceived external threat from an insect or insects to that organism." [GOC:add]


id: GO:0002215
name: defense response to nematode
namespace: biological_process
def:
  "A response to protect an organism from a directly detected or perceived external threat from a nematode or nematodes, which results in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack." [GOC:add, PMID:11516579, PMID:14506883]


id: GO:0002218
name: activation of innate immune response
namespace: biological_process
def:
  "Any process that initiates an innate immune response. Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. Examples of this process include activation of the hypersensitive response of Arabidopsis thaliana and activation of any NOD or TLR signaling pathway in vertebrate species." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, GOC:mtg_sensu, ISBN:0781735149, PMID:15199967, PMID:16177805]


id: GO:0002220
name: innate immune response activating cell surface receptor signaling pathway
namespace: biological_process
def:
  "Any series of molecular signals leading to activation of the innate immune response generated as a consequence of binding to a cell surface receptor." [GOC:add, ISBN:0781735149, PMID:15199967]


id: GO:0002221
name: pattern recognition receptor signaling pathway
namespace: biological_process
def:
  "Any series of molecular signals generated as a consequence of a pattern recognition receptor (PRR) binding to one of its physiological ligands. PRRs bind pathogen-associated molecular pattern (PAMPs), structures conserved among microbial species, or damage-associated molecular pattern (DAMPs), endogenous molecules released from damaged cells." [GOC:add, GOC:ar, ISBN:0781735149, PMID:15199967]


id: GO:0002222
name: stimulatory killer cell immunoglobulin-like receptor signaling pathway
namespace: biological_process
def:
  "Any series of molecular signals generated as a consequence of binding to a killer cell immunoglobulin-like receptor capable of cellular activation." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:0781735149]


id: GO:0002223
name: stimulatory C-type lectin receptor signaling pathway
namespace: biological_process
def:
  "Any series of molecular signals generated as a consequence of binding to a C-type lectin receptor capable of cellular activation." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:0781735149]


id: GO:0002224
name: toll-like receptor signaling pathway
namespace: biological_process
def:
  "Any series of molecular signals generated as a consequence of binding to a toll-like receptor. Toll-like receptors directly bind pattern motifs from a variety of microbial sources to initiate innate immune response." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:0781735149, PMID:12467241, PMID:12524386, PMID:12855817, PMID:15585605, PMID:15728447]


id: GO:0002225
name: positive regulation of antimicrobial peptide production
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate, or extent of antimicrobial peptide production." [GOC:add, PMID:11807545]


id: GO:0002227
name: innate immune response in mucosa
namespace: biological_process
def:
  "Any process of the innate immune response that takes place in the mucosal tissues." [GOC:add, PMID:10719665, PMID:15971105]


id: GO:0002228
name: natural killer cell mediated immunity
namespace: biological_process
def:
  "The promotion of an immune response by natural killer cells through direct recognition of target cells or through the release of cytokines." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:0781735149]


id: GO:0002229
name: defense response to oomycetes
namespace: biological_process
def:
  "Reactions triggered in response to the presence of oomycetes that act to protect the cell or organism." [GOC:add, PMID:16497589]


id: GO:0002230
name: positive regulation of defense response to virus by host
namespace: biological_process
def:
  "Any host process that results in the promotion of antiviral immune response mechanisms, thereby limiting viral replication." [GOC:add, GOC:dph, GOC:tb, ISBN:0781735149]


id: GO:0002231
name: detection of oomycetes
namespace: biological_process
def:
  "The series of events in which a stimulus from an oomycetes is received and converted into a molecular signal." [GOC:add, PMID:15922649]


id: GO:0002232
name: leukocyte chemotaxis involved in inflammatory response
namespace: biological_process
def:
  "The movement of an immune cell in response to an external stimulus contributing to an inflammatory response." [GOC:add, ISBN:0781735149]


id: GO:0002233
name: leukocyte chemotaxis involved in immune response
namespace: biological_process
def:
  "The movement of an immune cell in response to an external stimulus a part of an immune response." [GOC:add, ISBN:0781735149]


id: GO:0002234
name: detection of endoplasmic reticulum overloading
namespace: biological_process
def:
  "The series of events in which a stimulus generated by the accumulation of normal or misfolded proteins in the endoplasmic reticulum is received and converted into a molecular signal." [GOC:add, PMID:10390516]


id: GO:0002235
name: detection of unfolded protein
namespace: biological_process
def:
  "The series of events in which an unfolded protein stimulus is received and converted into a molecular signal." [GOC:add, PMID:15226511, PMID:7765470]


id: GO:0002236
name: detection of misfolded protein
namespace: biological_process
def:
  "The series of events in which a misfolded protein stimulus is received and converted into a molecular signal." [GOC:add, PMID:15226511]


id: GO:0002237
name: response to molecule of bacterial origin
namespace: biological_process
def:
  "Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus by molecules of bacterial origin such as peptides derived from bacterial flagellin." [GOC:rl, GOC:sm]


id: GO:0002238
name: response to molecule of fungal origin
namespace: biological_process
def:
  "Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus by molecules of fungal origin such as chito-octamer oligosaccharide." [GOC:rl, GOC:sm]


id: GO:0002239
name: response to oomycetes
namespace: biological_process
def:
  "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from an oomycetes." [GOC:add, PMID:16497589]


id: GO:0002240
name: response to molecule of oomycetes origin
namespace: biological_process
def:
  "Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus by molecules of oomycetes origin." [GOC:rl, GOC:sm]


id: GO:0002241
name: response to parasitic plant
namespace: biological_process
def:
  "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a parasitic plant." [GOC:add, PMID:16547862]


id: GO:0002242
name: defense response to parasitic plant
namespace: biological_process
def:
  "Reactions triggered in response to the presence of a parasitic plant that act to protect an organism." [GOC:add]


id: GO:0002243
name: detection of parasitic plant
namespace: biological_process
def:
  "The series of events in which a stimulus from a parasitic plant is received and converted into a molecular signal." [GOC:add, PMID:16547862]


id: GO:0002244
name: hematopoietic progenitor cell differentiation
namespace: biological_process
def:
  "The process in which precursor cell type acquires the specialized features of a hematopoietic progenitor cell, a class of cell types including myeloid progenitor cells and lymphoid progenitor cells." [GOC:add, GOC:rl, ISBN:0781735149, PMID:16551251]


id: GO:0002246
name: wound healing involved in inflammatory response
namespace: biological_process
def:
  "The series of events that restore integrity to damaged tissue that contribute to an inflammatory response." [GOC:jal, ISBN:0721601871]


id: GO:0002247
name: clearance of damaged tissue involved in inflammatory response wound healing
namespace: biological_process
def:
  "The series of events leading to removal of necrotic debris that contribute to an inflammatory response." [GOC:jal, ISBN:0721601871]


id: GO:0002248
name: connective tissue replacement involved in inflammatory response wound healing
namespace: biological_process
def:
  "The series of events leading to growth of connective tissue when loss of tissues that are incapable of regeneration occurs, or when fibrinous exudate cannot be adequately cleared that contribute to an inflammatory response." [GOC:jal, ISBN:0721601871]


id: GO:0002250
name: adaptive immune response
namespace: biological_process
def:
  "An immune response based on directed amplification of specific receptors for antigen produced through a somatic diversification process, and allowing for enhanced response to subsequent exposures to the same antigen (immunological memory)." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:0781735149]


id: GO:0002251
name: organ or tissue specific immune response
namespace: biological_process
def:
  "An immune response taking place in an organ or tissues such as the liver, brain, mucosa, or nervous system tissues." [GO_REF:0000022, GOC:jal, GOC:mtg_15nov05]


id: GO:0002252
name: immune effector process
namespace: biological_process
def:
  "Any process of the immune system that can potentially contribute to an immune response." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:0781735149]


id: GO:0002253
name: activation of immune response
namespace: biological_process
def:
  "Any process that initiates an immune response." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:0781735149]


id: GO:0002254
name: kinin cascade
namespace: biological_process
def:
  "A series of reactions that takes place outside the cell that occur as a result of by-products of tissue damage, including collagen, cartilage, and basement membrane. The ultimate product of the kinin cascade include kallidin and bradykinin, agents known to induce smooth muscle contraction, vasoconstriction, and increased vascular permeability." [GOC:jal, ISBN:0721601871, PMID:11842287, PMID:14501145]


id: GO:0002255
name: tissue kallikrein-kinin cascade
namespace: biological_process
def:
  "A series of reactions that takes place outside the cell initiated by the action of tissue (glandular) kallikreins on low molecular weight kininogen in response to tissue damage. Tissue kallikreins are present in glandular tissues and their fluids, such as the salivary glands, sweat glands, pancreas, and kidney. The ultimate products of the tissue kallikrein-kinin cascade include kallidin and bradykinin, agents known to induce smooth muscle contraction, vasoconstriction, and increased vascular permeability." [GOC:add, PMID:11842287, PMID:14501145]


id: GO:0002257
name: negative regulation of kinin cascade
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate, or extent of the kinin cascade." [GOC:jal]


id: GO:0002258
name: positive regulation of kinin cascade
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate, or extent of the kinin cascade." [GOC:jal]


id: GO:0002259
name: endothelial cell activation within high endothelial venule involved in immune response
namespace: biological_process
def:
  "A change in the morphology or behavior of an endothelial cell within a high endothelial venule resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149]


id: GO:0002260
name: lymphocyte homeostasis
namespace: biological_process
def:
  "The process of regulating the proliferation and elimination of lymphocytes such that the total number of lymphocytes within a whole or part of an organism is stable over time in the absence of an outside stimulus." [GOC:add, PMID:15826826, PMID:16319493, PMID:16551252, PMID:16551262]


id: GO:0002261
name: mucosal lymphocyte homeostasis
namespace: biological_process
def:
  "The process of regulating the proliferation and elimination of lymphocytes such that the total number of lymphocytes within the mucosal tissue of an organism is stable over time in the absence of an outside stimulus." [GOC:add, PMID:15609020]


id: GO:0002262
name: myeloid cell homeostasis
namespace: biological_process
def:
  "The process of regulating the proliferation and elimination of myeloid cells such that the total number of myeloid cells within a whole or part of an organism is stable over time in the absence of an outside stimulus." [CL:0000763, GOC:add]


id: GO:0002263
name: cell activation involved in immune response
namespace: biological_process
def:
  "A change in the morphology or behavior of a cell resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an immune response." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:0781735149]


id: GO:0002264
name: endothelial cell activation involved in immune response
namespace: biological_process
def:
  "A change in the morphology or behavior of an endothelial cell resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149]


id: GO:0002265
name: astrocyte activation involved in immune response
namespace: biological_process
def:
  "A change in the morphology or behavior of an astrocyte resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an immune response." [GOC:add, PMID:11138785]


id: GO:0002266
name: follicular dendritic cell activation
namespace: biological_process
def:
  "A change in the morphology or behavior of a follicular dendritic cell resulting from exposure to an activating factor such as a cellular or soluble ligand." [GOC:add, PMID:15606789]


id: GO:0002267
name: follicular dendritic cell activation involved in immune response
namespace: biological_process
def:
  "A change in the morphology or behavior of a follicular dendritic cell resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an immune response." [GOC:add, PMID:15606789]


id: GO:0002268
name: follicular dendritic cell differentiation
namespace: biological_process
def:
  "The process in which a relatively unspecialized precursor cell acquires the specialized features of a follicular dendritic cell." [GOC:add, ISBN:0781735149]


id: GO:0002269
name: leukocyte activation involved in inflammatory response
namespace: biological_process
def:
  "A change in the morphology or behavior of a leukocyte resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an inflammatory response." [GOC:add, ISBN:0781735149]


id: GO:0002270
name: plasmacytoid dendritic cell activation
namespace: biological_process
def:
  "A change in the morphology or behavior of a plasmacytoid dendritic cell resulting from exposure to an activating factor such as a cellular or soluble ligand." [GOC:add, PMID:15990333, PMID:16174109]


id: GO:0002271
name: plasmacytoid dendritic cell activation involved in immune response
namespace: biological_process
def:
  "A change in the morphology or behavior of a plasmacytoid dendritic cell resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an immune response." [GOC:add, PMID:15990333, PMID:16174109]


id: GO:0002272
name: plasmacytoid dendritic cell differentiation involved in immune response
namespace: biological_process
def:
  "The process in which an immature plasmacytoid dendritic cell acquires the specialized features of a mature plasmacytoid dendritic cell contributing to an immune response." [GOC:add, PMID:15990333]


id: GO:0002273
name: plasmacytoid dendritic cell differentiation
namespace: biological_process
def:
  "The process in which a relatively unspecialized hemopoietic precursor cell acquires the specialized features of a plasmacytoid dendritic cell." [GOC:add, PMID:15990333, PMID:16174108]


id: GO:0002274
name: myeloid leukocyte activation
namespace: biological_process
def:
  "A change in the morphology or behavior of a myeloid leukocyte resulting from exposure to an activating factor such as a cellular or soluble ligand." [GOC:add, ISBN:0781735149]


id: GO:0002275
name: myeloid cell activation involved in immune response
namespace: biological_process
def:
  "A change in the morphology or behavior of a myeloid cell resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149]


id: GO:0002276
name: basophil activation involved in immune response
namespace: biological_process
def:
  "A change in morphology and behavior of a basophil resulting from exposure to a cytokine, chemokine, soluble factor, or to (at least in mammals) an antigen which the basophil has specifically bound via IgE bound to Fc-epsilonRI receptors, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149]


id: GO:0002277
name: myeloid dendritic cell activation involved in immune response
namespace: biological_process
def:
  "The change in morphology and behavior of a myeloid dendritic cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149]


id: GO:0002278
name: eosinophil activation involved in immune response
namespace: biological_process
def:
  "The change in morphology and behavior of a eosinophil resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149]


id: GO:0002279
name: mast cell activation involved in immune response
namespace: biological_process
def:
  "The change in morphology and behavior of a mast cell resulting from exposure to a cytokine, chemokine, soluble factor, or to (at least in mammals) an antigen which the mast cell has specifically bound via IgE bound to Fc-epsilonRI receptors, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149]


id: GO:0002280
name: monocyte activation involved in immune response
namespace: biological_process
def:
  "The change in morphology and behavior of a monocyte resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149, PMID:16551245]


id: GO:0002281
name: macrophage activation involved in immune response
namespace: biological_process
def:
  "A change in morphology and behavior of a macrophage resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149]


id: GO:0002282
name: microglial cell activation involved in immune response
namespace: biological_process
def:
  "The change in morphology and behavior of a microglial cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149]


id: GO:0002283
name: neutrophil activation involved in immune response
namespace: biological_process
def:
  "The change in morphology and behavior of a neutrophil resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149]


id: GO:0002284
name: myeloid dendritic cell differentiation involved in immune response
namespace: biological_process
def:
  "The process in which an immature myeloid dendritic cell acquires the specialized features of a mature myeloid dendritic cell as part of an immune response." [GOC:add, ISBN:0781735149]


id: GO:0002285
name: lymphocyte activation involved in immune response
namespace: biological_process
def:
  "A change in morphology and behavior of a lymphocyte resulting from exposure to a specific antigen, mitogen, cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149]


id: GO:0002286
name: T cell activation involved in immune response
namespace: biological_process
def:
  "The change in morphology and behavior of a mature or immature T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149]


id: GO:0002287
name: alpha-beta T cell activation involved in immune response
namespace: biological_process
def:
  "The change in morphology and behavior of an alpha-beta T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149]


id: GO:0002288
name: NK T cell activation involved in immune response
namespace: biological_process
def:
  "The change in morphology and behavior of a mature or immature natural killer T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific, leading to the initiation or perpetuation of an immune response." [GOC:add, PMID:15771592]


id: GO:0002289
name: NK T cell proliferation involved in immune response
namespace: biological_process
def:
  "The expansion of a NK T cell population by cell division as part of an immune response." [GOC:add, PMID:15771592]


id: GO:0002290
name: gamma-delta T cell activation involved in immune response
namespace: biological_process
def:
  "The change in morphology and behavior of a gamma-delta T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific, leading to the initiation or perpetuation of an immune response." [GOC:add, PMID:8717523]


id: GO:0002291
namespace: biological_process
name:
  T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell

def:
  "The change in morphology and behavior of a mature or immature T cell resulting from exposure to an antigen for which its T cell receptor is specific bound to an MHC molecule on an antigen presenting cell, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149]


id: GO:0002292
name: T cell differentiation involved in immune response
namespace: biological_process
def:
  "The process in which an antigenically naive T cell acquires the specialized features of an effector, regulatory, or memory T cell as part of an immune response. Effector T cells include cells which provide T cell help or exhibit cytotoxicity towards other cells." [GOC:add, ISBN:0781735149]


id: GO:0002293
name: alpha-beta T cell differentiation involved in immune response
namespace: biological_process
def:
  "The process in which an antigenically naive alpha-beta T cell acquires the specialized features of an effector, regulatory, or memory T cell during an immune response. Effector T cells include cells which provide T cell help or exhibit cytotoxicity towards other cells." [GOC:add, ISBN:0781735149]


id: GO:0002294
name: CD4-positive, alpha-beta T cell differentiation involved in immune response
namespace: biological_process
def:
  "The process in which an antigenically naive CD4-positive, alpha-beta T cell acquires the specialized features of an effector, regulatory, or memory T cell as part of an immune response. Effector T cells include cells which provide T cell help or exhibit cytotoxicity towards other cells." [GOC:add, ISBN:0781735149]


id: GO:0002295
name: T-helper cell lineage commitment
namespace: biological_process
def:
  "The process in which a CD4-positive, alpha-beta T cell becomes committed to becoming a T-helper cell, a CD4-positive, alpha-beta T cell specialized to promote various immunological processes." [GOC:add, ISBN:0781735149]


id: GO:0002296
name: T-helper 1 cell lineage commitment
namespace: biological_process
def:
  "The process in which a CD4-positive, alpha-beta T cell becomes committed to becoming a T-helper 1 cell, a CD4-positive, alpha-beta T cell specialized to promote immunological processes often associated with resistance to intracellular bacteria, fungi, and protozoa, and pathological conditions such as arthritis." [GOC:add, ISBN:0781735149]


id: GO:0002297
name: T-helper 2 cell lineage commitment
namespace: biological_process
def:
  "The process in which a CD4-positive, alpha-beta T cell becomes committed to becoming a T-helper 2 cell, a CD4-positive, alpha-beta T cell specialized to promote immunological processes often associated with resistance to extracellular organisms such as helminths, enhanced production of particular antibody isotypes, and pathological conditions such as allergy." [GOC:add, ISBN:0781735149]


id: GO:0002298
namespace: biological_process
name:
  CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response

def:
  "The process in which an antigenically naive CD4-positive, alpha-beta T cell acquires the specialized features of a CD4-positive, CD25-positive, alpha-beta regulatory T cell as part of an immune response." [GOC:add, PMID:12093005]


id: GO:0002299
name: alpha-beta intraepithelial T cell differentiation
namespace: biological_process
def:
  "The process in which a precursor cell type acquires the specialized features of an alpha-beta intraepithelial T cell. Intraepithelial T cells are found among epithelial cells in mucosal areas and have distinct phenotypes and developmental pathways." [GOC:add, ISBN:0781735149]


id: GO:0002300
name: CD8-positive, alpha-beta intraepithelial T cell differentiation
namespace: biological_process
def:
  "The process in which a precursor cell type acquires the specialized features of a CD8-positive, alpha-beta intraepithelial T cell. Intraepithelial T cells are found among epithelial cells in mucosal areas and have distinct phenotypes and developmental pathways." [GOC:add, ISBN:0781735149]


id: GO:0002301
name: CD4-positive, alpha-beta intraepithelial T cell differentiation
namespace: biological_process
def:
  "The process in which a precursor cell type acquires the specialized features of a CD4-positive, alpha-beta intraepithelial T cell. Intraepithelial T cells are found among epithelial cells in mucosal areas and have distinct phenotypes and developmental pathways." [GOC:add, ISBN:0781735149]


id: GO:0002302
name: CD8-positive, alpha-beta T cell differentiation involved in immune response
namespace: biological_process
def:
  "The process in which an antigenically naive CD8-positive, alpha-beta T cell acquires the specialized features of an effector, regulatory, or memory T cell as part of an immune response. Effector T cells include cells which provide T cell help or exhibit cytotoxicity towards other cells." [GOC:add, ISBN:0781735149]


id: GO:0002303
name: gamma-delta T cell differentiation involved in immune response
namespace: biological_process
def:
  "The process in which an antigenically naive gamma-delta T cell acquires the specialized features of an effector, regulatory, or memory T cell and contributes to an immune response. Effector T cells include cells which provide T cell help or exhibit cytotoxicity towards other cells." [GOC:add]


id: GO:0002304
name: gamma-delta intraepithelial T cell differentiation
namespace: biological_process
def:
  "The process in which a precursor cell type acquires the specialized features of a gamma-delta intraepithelial T cell. Intraepithelial T cells are found among epithelial cells in mucosal areas and have distinct phenotypes and developmental pathways." [GOC:add, ISBN:0781735149]


id: GO:0002305
name: CD8-positive, gamma-delta intraepithelial T cell differentiation
namespace: biological_process
def:
  "The process in which a precursor cell type acquires the specialized features of a CD8-positive, gamma-delta intraepithelial T cell. Intraepithelial T cells are found among epithelial cells in mucosal areas and have distinct phenotypes and developmental pathways." [GOC:add, ISBN:0781735149]


id: GO:0002306
name: CD4-positive gamma-delta intraepithelial T cell differentiation
namespace: biological_process
def:
  "The process in which a precursor cell type acquires the specialized features of a CD4-positive, gamma-delta intraepithelial T cell. Intraepithelial T cells are found among epithelial cells in mucosal areas and have distinct phenotypes and developmental pathways." [GOC:add, ISBN:0781735149]


id: GO:0002307
name: CD8-positive, alpha-beta regulatory T cell differentiation
namespace: biological_process
def:
  "The process in which a precursor cell type acquires the specialized features of a CD8-positive, alpha-beta regulatory T cell." [GOC:add, ISBN:0781735149]


id: GO:0002308
name: CD8-positive, alpha-beta cytotoxic T cell differentiation
namespace: biological_process
def:
  "The process in which a precursor cell type acquires the specialized features of a CD8-positive, alpha-beta cytotoxic T cell." [GOC:add, ISBN:0781735149]


id: GO:0002309
name: T cell proliferation involved in immune response
namespace: biological_process
def:
  "The expansion of a T cell population by cell division as part of an immune response." [GOC:add, ISBN:0781735149]


id: GO:0002310
name: alpha-beta T cell proliferation involved in immune response
namespace: biological_process
def:
  "The expansion of an alpha-beta T cell population by cell division as part of an immune response." [GOC:add, ISBN:0781735149]


id: GO:0002311
name: gamma-delta T cell proliferation involved in immune response
namespace: biological_process
def:
  "The expansion of a gamma-delta T cell population by cell division as part of an immune response." [GOC:add]


id: GO:0002312
name: B cell activation involved in immune response
namespace: biological_process
def:
  "The change in morphology and behavior of a mature or immature B cell during an immune response, resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific." [GOC:jal]


id: GO:0002313
name: mature B cell differentiation involved in immune response
namespace: biological_process
def:
  "The process in which a naive B cell acquires the specialized features of a mature or memory B cell during an immune response." [GOC:jal]


id: GO:0002314
name: germinal center B cell differentiation
namespace: biological_process
def:
  "The process in which a B cell in the spleen acquires the specialized features of a germinal center B cell. Germinal center B cells are rapidly cycling B cells which have downregulated IgD expression and exhibit high levels of binding by peanut agglutinin (PNA)." [GOC:jal, ISBN:0781735149]


id: GO:0002315
name: marginal zone B cell differentiation
namespace: biological_process
def:
  "The process in which a B cell in the spleen acquires the specialized features of a marginal zone B cell. Marginal zone B cells are localized in a distinct anatomical region of the spleen that represents the major antigen-filtering and scavenging area (by specialized macrophages resident there). It appears that they are preselected to express a BCR repertoire similar to B-1 B cells, biased toward bacterial cell wall constituents and senescent self-components (such as oxidized LDL)." [GOC:jal, ISBN:0781735149]


id: GO:0002316
name: follicular B cell differentiation
namespace: biological_process
def:
  "The process in which a B cell in the spleen acquires the specialized features of a follicular B cell. Follicular B cells are major population of mature recirculating B cells in the spleen and are located in the B-cell follicle region." [GOC:jal, ISBN:0781735149]


id: GO:0002317
name: plasma cell differentiation
namespace: biological_process
def:
  "The process in which a B cell acquires the specialized features of a plasma cell. A plasma cell is a lymphocyte which develops from a B cell and produces high amounts of antibody." [GOC:jal]


id: GO:0002318
name: myeloid progenitor cell differentiation
namespace: biological_process
def:
  "The process in which a precursor cell type acquires the specialized features of a myeloid progenitor cell. Myeloid progenitor cells include progenitor cells for any of the myeloid lineages." [GOC:add, PMID:16551264]


id: GO:0002319
name: memory B cell differentiation
namespace: biological_process
def:
  "The process in which a B cell acquires the specialized features of a memory B cell. Memory B cells are cells that can respond rapidly to antigen re-exposure by production of high-affinity antibody." [GOC:jal, ISBN:0781735149]


id: GO:0002320
name: lymphoid progenitor cell differentiation
namespace: biological_process
def:
  "The process in which a precursor cell type acquires the specialized features of a lymphoid progenitor cell. Lymphoid progenitor cells include progenitor cells for any of the lymphoid lineages." [GOC:add, PMID:16551251, PMID:16551264]


id: GO:0002321
name: natural killer cell progenitor differentiation
namespace: biological_process
def:
  "The process in which a precursor cell type acquires the specialized features of a natural killer cell progenitor." [GOC:add, PMID:16551251, PMID:16551264]


id: GO:0002322
name: B cell proliferation involved in immune response
namespace: biological_process
def:
  "The expansion of a B cell population by cell division following B cell activation during an immune response." [GOC:jal]


id: GO:0002323
name: natural killer cell activation involved in immune response
namespace: biological_process
def:
  "The change in morphology and behavior of a natural killer cell resulting from exposure a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response." [GOC:add, PMID:15032583]


id: GO:0002324
name: natural killer cell proliferation involved in immune response
namespace: biological_process
def:
  "The expansion of a natural killer cell population by cell division as part of an immune response." [GOC:add, PMID:15032583]


id: GO:0002325
name: natural killer cell differentiation involved in immune response
namespace: biological_process
def:
  "The process in which a naive natural killer cell acquires the specialized features of an effector natural killer T cell as part of an immune response." [GOC:add, PMID:11698225]


id: GO:0002326
name: B cell lineage commitment
namespace: biological_process
def:
  "The process in which a lymphoid progenitor cell becomes committed to become any type of B cell." [GOC:add, ISBN:0781735149]


id: GO:0002327
name: immature B cell differentiation
namespace: biological_process
def:
  "The process in which a precursor cell type acquires the specialized features of an immature B cell." [GOC:jal, ISBN:0781735149, PMID:16551251]


id: GO:0002328
name: pro-B cell differentiation
namespace: biological_process
def:
  "The process in which a precursor cell type acquires the specialized features of a pro-B cell. Pro-B cells are the earliest stage of the B cell lineage and undergo heavy chain D and J gene rearrangements, although they are not fully committed." [GOC:jal, ISBN:0781735149]


id: GO:0002329
name: pre-B cell differentiation
namespace: biological_process
def:
  "The process in which a precursor cell type acquires the specialized features of a pre-B cell. Pre-B cells follow the pro-B cell stage of immature B cell differentiation and undergo rearrangement of heavy chain V, D, and J gene segments." [GOC:jal, ISBN:0781735149]


id: GO:0002330
name: pre-B cell receptor expression
namespace: biological_process
def:
  "The process leading up to expression of the pre-B cell receptor on the surface of pre-B cells, including expression of the surrogate light chain, association of the surrogate light chain with heavy chain, and expression of the complete pre-B cell receptor on the cell surface." [GOC:add, GOC:jal, ISBN:0781735149]


id: GO:0002331
name: pre-B cell allelic exclusion
namespace: biological_process
def:
  "Expression of a single heavy chain allele during pre-B cell differentiation." [GOC:add, GOC:jal, ISBN:0781735149]


id: GO:0002332
name: transitional stage B cell differentiation
namespace: biological_process
def:
  "The process in which immature B cells from the bone marrow become mature B cells in the spleen. Transitional stage B cells are subdivided into transitional one (T1) and transitional two (T2) stages and are short-lived and functionally incompetent." [GOC:jal, ISBN:0781735149]


id: GO:0002333
name: transitional one stage B cell differentiation
namespace: biological_process
def:
  "The process in which immature B cells from the bone marrow acquire the specialized features of T1 stage B cells in the spleen. T1 stage B cells do not express either CD23 or CD21." [GOC:jal, ISBN:0781735149]


id: GO:0002334
name: transitional two stage B cell differentiation
namespace: biological_process
def:
  "The process in which immature B cells from the bone marrow acquire the specialized features of T2 stage B cells in the spleen. T2 stage B cells express CD23 but not CD21." [GOC:jal, ISBN:0781735149]


id: GO:0002335
name: mature B cell differentiation
namespace: biological_process
def:
  "The process in which transitional stage B cells acquire the specialized features of mature B cells in the spleen." [GOC:jal, ISBN:0781735149]


id: GO:0002336
name: B-1 B cell lineage commitment
namespace: biological_process
def:
  "The process in which an immature B cell becomes committed to become a B-1 B cell." [GOC:jal, ISBN:0781735149]


id: GO:0002337
name: B-1a B cell differentiation
namespace: biological_process
def:
  "The process in which B cells acquire the specialized features of B-1a B cells. B-1a B cells are B-1 cells that express CD5 and arise from fetal liver precursors." [GOC:jal, ISBN:0781735149]


id: GO:0002338
name: B-1b B cell differentiation
namespace: biological_process
def:
  "The process in which B cells acquire the specialized features of B-1b B cells. B-1b B cells are B-1 cells that do not express CD5." [GOC:jal, ISBN:0781735149]


id: GO:0002339
name: B cell selection
namespace: biological_process
def:
  "The process dependent upon B cell antigen receptor signaling in response to self or foreign antigen through which B cells are selected for survival." [GOC:jal]


id: GO:0002341
name: central B cell anergy
namespace: biological_process
def:
  "Any process contributing to anergy, a state of functional inactivation that occurs as part of tolerance induction, in B cells in the bone marrow." [GOC:jal]


id: GO:0002342
name: central B cell deletion
namespace: biological_process
def:
  "The deletion of B cells by apoptotic process occurring as part of central tolerance induction and B cell selection." [GOC:add, GOC:jal, GOC:mtg_apoptosis]


id: GO:0002344
name: B cell affinity maturation
namespace: biological_process
def:
  "The process in which B cells produce antibodies with increased antigen affinity. This is accomplished by somatic hypermutation and selection for B cells which produce higher affinity antibodies to antigen." [GO_REF:0000022, GOC:jal, GOC:mtg_15nov05, ISBN:0781735149]


id: GO:0002345
name: peripheral B cell receptor editing
namespace: biological_process
def:
  "The process that takes place mainly in germinal center B cells in which a large number of mutations are generated in the heavy chain and light chain V-region genes and their immediately surrounding introns in order to increase antibody diversity and contribute to affinity maturation." [GOC:jal]


id: GO:0002346
name: B cell positive selection
namespace: biological_process
def:
  "Any process in which B cells are selected to survive based on signaling through the B cell antigen receptor." [GOC:jal]


id: GO:0002347
name: response to tumor cell
namespace: biological_process
def:
  "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a tumor cell." [GOC:add, ISBN:0781735149, PMID:16730260]


id: GO:0002348
name: central B cell positive selection
namespace: biological_process
def:
  "Any process leading to positive selection of B cells in the bone marrow. Positive selection is the process in which B or T cells are selected to survive based on signaling through their antigen receptors." [GOC:jal]


id: GO:0002349
name: histamine production involved in inflammatory response
namespace: biological_process
def:
  "The synthesis or release of histamine following a stimulus as part of an inflammatory response, resulting in an increase in its intracellular or extracellular levels." [GOC:add, ISBN:0781735149, PMID:16730260]


id: GO:0002350
name: peripheral B cell positive selection
namespace: biological_process
def:
  "Any process leading to positive selection of B cells in the periphery. Positive selection is the process in which B or T cells are selected to survive based on signaling through their antigen receptors." [GOC:jal]


id: GO:0002351
name: serotonin production involved in inflammatory response
namespace: biological_process
def:
  "The synthesis or release of serotonin following a stimulus as part of an inflammatory response, resulting in an increase in its intracellular or extracellular levels." [GOC:add, ISBN:0781735149, PMID:16730260]


id: GO:0002352
name: B cell negative selection
namespace: biological_process
def:
  "Any process leading to negative selection in B cells. Mechanisms of negative selection include anergy and deletion." [GOC:jal]


id: GO:0002353
name: plasma kallikrein-kinin cascade
namespace: biological_process
def:
  "A series of reactions that takes place outside the cell occurring in response to tissue damage and initiated within blood plasma by the action of activated Factor XII (Hageman Factor) on prekallikrein to convert it to plasma kallikrein, and the subsequent reaction of plasma kallikrein with high molecular weight kininogen. The ultimate product of the plasma kallikrein-kinin cascade is bradykinin, an agent known to induce smooth muscle contraction, vasoconstriction, and increased vascular permeability." [GOC:add, ISBN:0721601871, PMID:11842287, PMID:14501145]


id: GO:0002355
name: detection of tumor cell
namespace: biological_process
def:
  "The series of events in which a stimulus from a tumor cell is received and converted into a molecular signal." [GOC:add, ISBN:0781735149, PMID:16730260]


id: GO:0002357
name: defense response to tumor cell
namespace: biological_process
def:
  "Reactions triggered in response to the presence of a tumor cell that act to protect the cell or organism." [GOC:add, ISBN:0781735149, PMID:16730260]


id: GO:0002358
name: B cell homeostatic proliferation
namespace: biological_process
def:
  "The non-specific expansion of B cell populations within a whole or part of an organism to reach to a total number of B cells which will then remain stable over time in the absence of an external stimulus." [GOC:jal]


id: GO:0002360
name: T cell lineage commitment
namespace: biological_process
def:
  "The process in which a lymphoid progenitor cell becomes committed to becoming any type of T cell." [GOC:add, ISBN:0781735149]


id: GO:0002361
name: CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation
namespace: biological_process
def:
  "The process in which a precursor cell type acquires the specialized features of a CD4-positive, CD25-positive, alpha-beta regulatory T cell." [GOC:add, PMID:15207821]


id: GO:0002362
name: CD4-positive, CD25-positive, alpha-beta regulatory T cell lineage commitment
namespace: biological_process
def:
  "The process in which a CD4-positive, alpha-beta T cell becomes committed to becoming a CD4-positive, CD25-positive, alpha-beta regulatory T cell." [GOC:add, PMID:15207821]


id: GO:0002363
name: alpha-beta T cell lineage commitment
namespace: biological_process
def:
  "The process in which a pro-T cell becomes committed to becoming an alpha-beta T cell." [GOC:add, ISBN:0781735149]


id: GO:0002364
name: NK T cell lineage commitment
namespace: biological_process
def:
  "The process in which a pro-T cell becomes committed to becoming an NK T cell." [GOC:add, ISBN:0781735149]


id: GO:0002365
name: gamma-delta T cell lineage commitment
namespace: biological_process
def:
  "The process in which a pro-T cell becomes committed to becoming a gamma-delta T cell." [GOC:add, ISBN:0781735149]


id: GO:0002366
name: leukocyte activation involved in immune response
namespace: biological_process
def:
  "A change in morphology and behavior of a leukocyte resulting from exposure to a specific antigen, mitogen, cytokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149]


id: GO:0002367
name: cytokine production involved in immune response
namespace: biological_process
def:
  "The appearance of a cytokine due to biosynthesis or secretion following a cellular stimulus contributing to an immune response, resulting in an increase in its intracellular or extracellular levels." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:0781735149]


id: GO:0002370
name: natural killer cell cytokine production
namespace: biological_process
def:
  "Any process that contributes to cytokine production by a natural killer cell." [GOC:add, ISBN:0781735149]


id: GO:0002371
name: dendritic cell cytokine production
namespace: biological_process
def:
  "Any process that contributes to cytokine production by a dendritic cell." [GOC:add, ISBN:0781735149]


id: GO:0002372
name: myeloid dendritic cell cytokine production
namespace: biological_process
def:
  "Any process that contributes to cytokine production by a myeloid dendritic cell." [GOC:add, ISBN:0781735149]


id: GO:0002373
name: plasmacytoid dendritic cell cytokine production
namespace: biological_process
def:
  "Any process that contributes to cytokine production by a plasmacytoid dendritic cell." [GOC:add, ISBN:0781735149]


id: GO:0002374
name: cytokine secretion involved in immune response
namespace: biological_process
def:
  "The regulated release of cytokines from a cell that contributes to an immune response." [GOC:add, ISBN:0781735149]


id: GO:0002375
name: cytokine biosynthetic process involved in immune response
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of a cytokine that contributes to an immune response." [GOC:add, ISBN:0781735149]


id: GO:0002376
name: immune system process
namespace: biological_process
def:
  "Any process involved in the development or functioning of the immune system, an organismal system for calibrated responses to potential internal or invasive threats." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05]


id: GO:0002377
name: immunoglobulin production
namespace: biological_process
def:
  "The appearance of immunoglobulin due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:add, ISBN:0781735149]


id: GO:0002378
name: immunoglobulin biosynthetic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of immunoglobulin." [GOC:add, ISBN:0781735149]


id: GO:0002379
name: immunoglobulin biosynthetic process involved in immune response
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of immunoglobulin contributing to an immune response." [GOC:add, ISBN:0781735149]


id: GO:0002380
name: immunoglobulin secretion involved in immune response
namespace: biological_process
def:
  "The regulated release of immunoglobulins from a B cell or plasma cell contributing to an immune response." [GOC:add, ISBN:0781735149, PMID:9185563]


id: GO:0002381
name: immunoglobulin production involved in immunoglobulin mediated immune response
namespace: biological_process
def:
  "The appearance of immunoglobulin due to biosynthesis or secretion following a cellular stimulus during an immune response, resulting in an increase in its intracellular or extracellular levels." [GOC:add, ISBN:0781735149]


id: GO:0002382
name: regulation of tissue kallikrein-kinin cascade
namespace: biological_process
def:
  "Any process that modulates the frequency, rate, or extent of the tissue kallikrein-kinin cascade." [GOC:add]


id: GO:0002383
name: immune response in brain or nervous system
namespace: biological_process
def:
  "An immune response taking place in the brain or nervous system." [GO_REF:0000022, GOC:jal, GOC:mtg_15nov05, ISBN:0781735149]


id: GO:0002384
name: hepatic immune response
namespace: biological_process
def:
  "An immune response taking place in the liver." [GO_REF:0000022, GOC:jal, GOC:mtg_15nov05, ISBN:0781735149]


id: GO:0002385
name: mucosal immune response
namespace: biological_process
def:
  "An immune response taking place in mucosal tissues, including those of the intestinal tract, nasal and upper respiratory tract, and genital tract." [GO_REF:0000022, GOC:jal, GOC:mtg_15nov05, ISBN:0781735149]


id: GO:0002386
name: immune response in mucosal-associated lymphoid tissue
namespace: biological_process
def:
  "Immune response taking place in the mucosal-associated lymphoid tissue (MALT). Mucosal-associated lymphoid tissue is typically found as nodules associated with mucosal epithelia with distinct internal structures including B- and T-zones for the activation of lymphocytes." [GOC:jal, ISBN:0781735149]


id: GO:0002387
name: immune response in gut-associated lymphoid tissue
namespace: biological_process
def:
  "Immune response taking place in the gut-associated lymphoid tissue (GALT). GALT includes Peyer's patches, appendix, and solitary lymph nodules." [GOC:jal, ISBN:0781735149]


id: GO:0002388
name: immune response in Peyer's patch
namespace: biological_process
def:
  "Immune response taking place in the Peyer's patch, nodular lymphoid structures on the serosal surface of the small intestine." [GOC:jal, ISBN:0781735149]


id: GO:0002390
name: platelet activating factor production
namespace: biological_process
def:
  "The synthesis or release of platelet activating factor following a stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:add, ISBN:0781735149]


id: GO:0002391
name: platelet activating factor production involved in inflammatory response
namespace: biological_process
def:
  "The synthesis or release of platelet activating factor following a stimulus as part of an inflammatory response, resulting in an increase in its intracellular or extracellular levels." [GOC:add, ISBN:0781735149]


id: GO:0002393
name: lysosomal enzyme production involved in inflammatory response
namespace: biological_process
def:
  "The synthesis or release of lysosomal enzymes following a stimulus as part of a inflammatory response, resulting in an increase in intracellular or extracellular levels." [GOC:add]


id: GO:0002394
name: tolerance induction in gut-associated lymphoid tissue
namespace: biological_process
def:
  "Tolerance induction taking place in the gut-associated lymphoid tissue (GALT)." [GOC:jal, ISBN:0781735149]


id: GO:0002395
name: immune response in nasopharyngeal-associated lymphoid tissue
namespace: biological_process
def:
  "An immune response taking place in the nasopharyngeal-associated lymphoid tissue (NALT). NALT includes the tonsils and adenoids." [GOC:jal, ISBN:0781735149]


id: GO:0002396
name: MHC protein complex assembly
namespace: biological_process
def:
  "The aggregation, arrangement and bonding together of a set of components to form an MHC protein complex." [GOC:add, ISBN:0781735149, PMID:15771591, PMID:15928678]


id: GO:0002397
name: MHC class I protein complex assembly
namespace: biological_process
def:
  "The aggregation, arrangement and bonding together of a set of components to form an MHC class I protein complex. Class I here refers to classical class I molecules." [GOC:add, ISBN:0781735149, PMID:15771591]


id: GO:0002398
name: MHC class Ib protein complex assembly
namespace: biological_process
def:
  "The aggregation, arrangement and bonding together of a set of components to form an MHC class Ib protein complex. Class Ib here refers to non-classical class I molecules." [GOC:add, PMID:15928678, PMID:15928680]


id: GO:0002399
name: MHC class II protein complex assembly
namespace: biological_process
def:
  "The aggregation, arrangement and bonding together of a set of components to form an MHC class II protein complex." [GOC:add, ISBN:0781735149, PMID:15771591]


id: GO:0002400
name: tolerance induction in nasopharyngeal-associated lymphoid tissue
namespace: biological_process
def:
  "Tolerance induction taking place in the nasopharyngeal-associated lymphoid tissue (NALT)." [GOC:jal, ISBN:0781735149]


id: GO:0002401
name: tolerance induction in mucosal-associated lymphoid tissue
namespace: biological_process
def:
  "Tolerance induction taking place in the mucosal-associated lymphoid tissue (MALT)." [GOC:jal, ISBN:0781735149]


id: GO:0002402
name: B cell tolerance induction in mucosal-associated lymphoid tissue
namespace: biological_process
def:
  "Tolerance induction taking place in the mucosal-associated lymphoid tissue (MALT) mediated by B cells." [GOC:jal, ISBN:0781735149]


id: GO:0002403
name: T cell tolerance induction in mucosal-associated lymphoid tissue
namespace: biological_process
def:
  "Tolerance induction taking place in the mucosal-associated lymphoid tissue (MALT) mediated by T cells." [GOC:jal, ISBN:0781735149, PMID:16551263]


id: GO:0002404
name: antigen sampling in mucosal-associated lymphoid tissue
namespace: biological_process
def:
  "The process of apical-to-basolateral delivery of soluble and particulate antigens to underlying mucosal-associated lymphoid tissue." [GOC:jal, PMID:11896763, PMID:12843411, PMID:15681746]


id: GO:0002405
name: antigen sampling by dendritic cells in mucosal-associated lymphoid tissue
namespace: biological_process
def:
  "The process of antigen sampling carried out by dendritic cells in the mucosal-associated lymphoid tissue." [GOC:jal, PMID:11896763, PMID:15681746]


id: GO:0002406
name: antigen sampling by M cells in mucosal-associated lymphoid tissue
namespace: biological_process
def:
  "The process of antigen samples carried out by M cells in the mucosal-associated lymphoid tissue." [GOC:jal, PMID:11896763]


id: GO:0002407
name: dendritic cell chemotaxis
namespace: biological_process
def:
  "The movement of a dendritic cell in response to an external stimulus." [CL:0000451, GOC:add, ISBN:0781735149, PMID:15814331, PMID:16056255]


id: GO:0002408
name: myeloid dendritic cell chemotaxis
namespace: biological_process
def:
  "The movement of a myeloid dendritic cell in response to an external stimulus." [GOC:add, ISBN:0781735149, PMID:15814331, PMID:16056255]


id: GO:0002409
name: Langerhans cell chemotaxis
namespace: biological_process
def:
  "The movement of a Langerhans cell in response to an external stimulus." [GOC:add, PMID:16056255, PMID:16387601]


id: GO:0002410
name: plasmacytoid dendritic cell chemotaxis
namespace: biological_process
def:
  "The movement of a plasmacytoid dendritic cell in response to an external stimulus." [GOC:add, PMID:15159375, PMID:15814331]


id: GO:0002411
name: T cell tolerance induction to tumor cell
namespace: biological_process
def:
  "A process of tolerance induction dependent on T cells which leads to immunological tolerance of a tumor." [GOC:add, ISBN:0781735149, PMID:16730260]


id: GO:0002412
name: antigen transcytosis by M cells in mucosal-associated lymphoid tissue
namespace: biological_process
def:
  "The process of antigen transcytosis carried out by M cells in the mucosal-associated lymphoid tissue (MALT). Transcytosis is the process of the directed movement of endocytosed material through the cell and its exocytosis from the plasma membrane at the opposite side. M cells are specialized epithelia cells with a microfold structure that are adept at moving antigens from the gut lumen to antigen presenting cells in the MALT." [GOC:jal, ISBN:0781735149, PMID:12843411]


id: GO:0002414
name: immunoglobulin transcytosis in epithelial cells
namespace: biological_process
def:
  "The process of transporting immunoglobulin, via transcytosis, from one side of an epithelial cell to the other." [GOC:add, ISBN:0781735149, ISBN:081533642X, PMID:16048543]


id: GO:0002415
name: immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor
namespace: biological_process
def:
  "The process of transporting polymeric IgA and polymeric IgM immunoglobulin, via transcytosis mediated by the polymeric immunoglobulin receptor (pIgR), from the basolateral surface to apical surface of an epithelial cell. At the apical surface the immunoglobulin binding portion of the pIgRis cleaved and remains bound to the transported immunoglobulin as secretory component (SC). The same process is used for the transport and excretion of IgA immune complexes to the luminal surface of the mucosa." [GOC:add, ISBN:0781735149, ISBN:081533642X, PMID:16048543]


id: GO:0002416
name: IgG immunoglobulin transcytosis in epithelial cells mediated by FcRn immunoglobulin receptor
namespace: biological_process
def:
  "The process of transporting IgG immunoglobulin, via transcytosis using the FcRn (also known as the neonatal Fc receptor; gene name FCGRT), from apical surface of an epithelial cell to the basolateral surface or vice versa depending on the location. This process is used for uptake of IgG from the milk in the gut in rodents, for transplacental transport of IgG from mother to embryo in humans, and for maintenance of a steady-state distribution of IgG across epithelial boundaries in general in adult mammals." [GOC:add, ISBN:0781735149, ISBN:081533642X]


id: GO:0002417
name: B cell antigen processing and presentation mediated by B cell receptor uptake of antigen
namespace: biological_process
def:
  "B cell antigen processing and presentation which is initiated by uptake of antigen bound to the B cell receptor." [GOC:add, ISBN:0781735149, PMID:15771591]


id: GO:0002418
name: immune response to tumor cell
namespace: biological_process
def:
  "An immune system process that functions in the response of an organism to a tumor cell." [GOC:add, ISBN:0781735149, PMID:16730260]


id: GO:0002419
name: T cell mediated cytotoxicity directed against tumor cell target
namespace: biological_process
def:
  "The directed killing of a tumor cell by a T cell through the release of granules containing cytotoxic mediators or through the engagement of death receptors." [GOC:add, ISBN:0781735149, PMID:16730260]


id: GO:0002420
name: natural killer cell mediated cytotoxicity directed against tumor cell target
namespace: biological_process
def:
  "The directed killing of a tumor cell by a natural killer cell through the release of granules containing cytotoxic mediators or through the engagement of death receptors." [GOC:add, ISBN:0781735149, PMID:16730260]


id: GO:0002421
name: B cell antigen processing and presentation following pinocytosis
namespace: biological_process
def:
  "B cell antigen processing and presentation which is initiated by uptake of antigen via pinocytosis." [GOC:add, PMID:7543530]


id: GO:0002423
name: natural killer cell mediated immune response to tumor cell
namespace: biological_process
def:
  "An immune response mediated by a natural killer cell triggered in response to the presence of a tumor cell." [GOC:add, ISBN:0781735149, PMID:16730260]


id: GO:0002424
name: T cell mediated immune response to tumor cell
namespace: biological_process
def:
  "An immune response mediated by a T cell triggered in response to the presence of a tumor cell." [GOC:add, ISBN:0781735149, PMID:16730260]


id: GO:0002428
name: antigen processing and presentation of peptide antigen via MHC class Ib
namespace: biological_process
def:
  "The process in which an antigen-presenting cell expresses peptide antigen in association with an MHC class Ib protein complex on its cell surface. The peptide antigen may originate from an endogenous or exogenous protein. Class Ib here refers to non-classical class I molecules, such as those of the HLA-E family." [GOC:add, PMID:15928678]


id: GO:0002429
name: immune response-activating cell surface receptor signaling pathway
namespace: biological_process
def:
  "A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of a cell capable of activating or perpetuating an immune response." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:0781735149]


id: GO:0002430
name: complement receptor mediated signaling pathway
namespace: biological_process
def:
  "A series of molecular signals generated as a consequence of a component of the complement pathway binding to a complement receptor. Such components include both whole complement proteins and fragments of complement proteins generated through the activity of the complement pathway." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:0781735149]


id: GO:0002431
name: Fc receptor mediated stimulatory signaling pathway
namespace: biological_process
def:
  "A series of molecular signals generated as a consequence of a the binding of the Fc portion of an immunoglobulin by an Fc receptor capable of activating or perpetuating an immune response. The Fc portion of an immunoglobulin is its C-terminal constant region." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:0781735149]


id: GO:0002432
name: granuloma formation
namespace: biological_process
def:
  "The formation of nodular inflammatory lesions, usually small or granular, firm, persistent, well-structured, and containing compactly grouped T lymphocytes and modified phagocytes such as epithelioid cells, giant cells, and other macrophages. Granuloma formation represents a chronic inflammatory response initiated by various infectious and noninfectious agents. The center of a granuloma consists of fused macrophages, which can become necrotic." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:068340007X, ISBN:0721601464, ISBN:081533642X]


id: GO:0002433
name: immune response-regulating cell surface receptor signaling pathway involved in phagocytosis
namespace: biological_process
def:
  "An immune response-regulating cell surface receptor signaling pathway that contributes to the endocytic engulfment of external particulate material by phagocytes." [GO_REF:0000022, GOC:add, GOC:bf, GOC:mtg_15nov05, ISBN:0781735149]


id: GO:0002434
name: immune complex clearance
namespace: biological_process
def:
  "A process directed at removing immune complexes from the body. Immune complexes are clusters of antibodies bound to antigen, to which complement may also be fixed, and which may precipitate or remain in solution." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:068340007X]


id: GO:0002437
name: inflammatory response to antigenic stimulus
namespace: biological_process
def:
  "An inflammatory response to an antigenic stimulus, which can be include any number of T cell or B cell epitopes." [GOC:add, ISBN:0781735149]


id: GO:0002438
name: acute inflammatory response to antigenic stimulus
namespace: biological_process
def:
  "An acute inflammatory response to an antigenic stimulus. An acute inflammatory response occurs within a matter of minutes or hours, and either resolves within a few days or becomes a chronic inflammatory response." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:0781735149]


id: GO:0002439
name: chronic inflammatory response to antigenic stimulus
namespace: biological_process
def:
  "A chronic inflammatory response to an antigenic stimulus. A chronic inflammatory response persists indefinitely during days, weeks, or months in the life of an individual." [GOC:add, ISBN:0781735149]


id: GO:0002440
name: production of molecular mediator of immune response
namespace: biological_process
def:
  "The synthesis or release of any molecular mediator of the immune response, resulting in an increase in its intracellular or extracellular levels." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:0781735149]


id: GO:0002441
name: histamine secretion involved in inflammatory response
namespace: biological_process
def:
  "The regulated release of histamine by a cell as part of an inflammatory response." [GOC:add, ISBN:0781735149]


id: GO:0002442
name: serotonin secretion involved in inflammatory response
namespace: biological_process
def:
  "The regulated release of serotonin by a cell as part of an inflammatory response." [GOC:add, ISBN:0781735149]


id: GO:0002443
name: leukocyte mediated immunity
namespace: biological_process
def:
  "Any process involved in the carrying out of an immune response by a leukocyte." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:0781735149]


id: GO:0002444
name: myeloid leukocyte mediated immunity
namespace: biological_process
def:
  "Any process involved in the carrying out of an immune response by a myeloid leukocyte." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:0781735149]


id: GO:0002445
name: type II hypersensitivity
namespace: biological_process
def:
  "An inflammatory response resulting in cell death or dysfunction mediated by activation of the classical complement pathway or induction of effector cell phagocytosis, cytolysis mechanisms via complement or Fc receptors following the binding of antibodies to cell surface antigens on a target cell, or mediated by the direct binding of antibody to cellular receptors." [GOC:add, ISBN:0781735149]


id: GO:0002446
name: neutrophil mediated immunity
namespace: biological_process
def:
  "Any process involved in the carrying out of an immune response by a neutrophil." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:0781735149]


id: GO:0002447
name: eosinophil mediated immunity
namespace: biological_process
def:
  "Any process involved in the carrying out of an immune response by an eosinophil." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:0781735149]


id: GO:0002448
name: mast cell mediated immunity
namespace: biological_process
def:
  "Any process involved in the carrying out of an immune response by a mast cell." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:0781735149]


id: GO:0002449
name: lymphocyte mediated immunity
namespace: biological_process
def:
  "Any process involved in the carrying out of an immune response by a lymphocyte." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:0781735149]


id: GO:0002450
name: B cell antigen processing and presentation
namespace: biological_process
def:
  "The process in which a B cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex." [GOC:add, ISBN:0781735149, PMID:15771591]


id: GO:0002451
name: peripheral B cell tolerance induction
namespace: biological_process
def:
  "Tolerance induction of mature B cells in the peripheral lymphoid tissues: the blood, lymph nodes, spleen, and mucosal-associated lymphoid tissue." [GOC:jal, ISBN:0781735149]


id: GO:0002452
name: B cell receptor editing
namespace: biological_process
def:
  "The process of replacing receptors on B cells, in which RAG gene expression allows continued light-chain gene rearrangement and expression of a new light change which combines with the previous heavy chain to form a new receptor." [GOC:jal, ISBN:0781735149]


id: GO:0002453
name: peripheral B cell anergy
namespace: biological_process
def:
  "Any process contributing to anergy, a state of functional inactivation that occurs as part of tolerance induction, in peripheral B cells." [GOC:jal, ISBN:0781735149]


id: GO:0002454
name: peripheral B cell deletion
namespace: biological_process
def:
  "The deletion of B cells by apoptotic process occurring as part of peripheral tolerance induction and B cell selection." [GOC:add, GOC:jal, GOC:mtg_apoptosis, ISBN:0781735149]


id: GO:0002455
name: humoral immune response mediated by circulating immunoglobulin
namespace: biological_process
def:
  "An immune response dependent upon secreted immunoglobulin. An example of this process is found in Mus musculus." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:0781735149]


id: GO:0002456
name: T cell mediated immunity
namespace: biological_process
def:
  "Any process involved in the carrying out of an immune response by a T cell." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:0781735149]


id: GO:0002457
name: T cell antigen processing and presentation
namespace: biological_process
def:
  "The process in which a T cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex." [GOC:add, PMID:11417857, PMID:15120183]


id: GO:0002458
name: peripheral T cell tolerance induction
namespace: biological_process
def:
  "Tolerance induction of T cells in the periphery, in this case, any location in the body other than the thymus." [GOC:jal, ISBN:0781735149]


id: GO:0002459
namespace: biological_process
name:
  adaptive immune response based on somatic recombination of immune receptors built from leucine-rich repeat domains

def:
  "An immune response based on directed amplification of specific receptors for antigen produced through a somatic diversification process that includes somatic recombination of variable lymphocyte receptors (VLR) incorporating leucine-rich repeat (LRR) domains, and allowing for enhanced responses upon subsequent exposures to the same antigen (immunological memory). Examples of this process are found in jawless fish, including the lampreys (Petromyzontidae) and hagfishes (Myxinidae)." [GOC:add, GOC:mtg_sensu, PMID:16373579]


id: GO:0002460
namespace: biological_process
name:
  adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains

def:
  "An immune response based on directed amplification of specific receptors for antigen produced through a somatic diversification process that includes somatic recombination of germline gene segments encoding immunoglobulin superfamily domains, and allowing for enhanced responses upon subsequent exposures to the same antigen (immunological memory). Recombined receptors for antigen encoded by immunoglobulin superfamily domains include T cell receptors and immunoglobulins (antibodies). An example of this is the adaptive immune response found in Mus musculus." [GOC:add, GOC:mtg_sensu, ISBN:0781735149]


id: GO:0002461
name: tolerance induction dependent upon immune response
namespace: biological_process
def:
  "Tolerance induction dependent upon an immune response, typically a response by a mature T or B cell in the periphery resulting tolerance towards an antigen via induction of anergy, cellular deletion, or regulatory T cell activation." [GO_REF:0000022, GOC:jal, GOC:mtg_15nov05, ISBN:0781735149]


id: GO:0002462
name: tolerance induction to nonself antigen
namespace: biological_process
def:
  "Tolerance induction in response to nonself antigens." [GO_REF:0000022, GOC:jal, GOC:mtg_15nov05, ISBN:0781735149]


id: GO:0002465
name: peripheral tolerance induction
namespace: biological_process
def:
  "Tolerance induction in the peripheral lymphoid tissues: blood, lymph nodes, spleen, and mucosal-associated lymphoid tissues." [GO_REF:0000022, GOC:jal, GOC:mtg_15nov05, ISBN:0781735149]


id: GO:0002466
name: peripheral tolerance induction to self antigen
namespace: biological_process
def:
  "Tolerance induction to self antigens in the peripheral lymphoid tissues: blood, lymph nodes, spleen, and mucosal-associated lymphoid tissues." [GOC:jal, ISBN:0781735149]


id: GO:0002467
name: germinal center formation
namespace: biological_process
def:
  "The process in which germinal centers form. A germinal center is a specialized microenvironment formed when activated B cells enter lymphoid follicles. Germinal centers are the foci for B cell proliferation and somatic hypermutation." [GO_REF:0000022, GOC:jal, GOC:mtg_15nov05, ISBN:081533642X]


id: GO:0002468
name: dendritic cell antigen processing and presentation
namespace: biological_process
def:
  "The process in which a dendritic cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex." [GOC:add, ISBN:0781735149, PMID:15771591]


id: GO:0002469
name: myeloid dendritic cell antigen processing and presentation
namespace: biological_process
def:
  "The process in which a myeloid dendritic cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex." [GOC:add, ISBN:0781735149, PMID:15771591]


id: GO:0002470
name: plasmacytoid dendritic cell antigen processing and presentation
namespace: biological_process
def:
  "The process in which a plasmacytoid dendritic cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex." [GOC:add, ISBN:0781735149, PMID:15771591]


id: GO:0002471
name: monocyte antigen processing and presentation
namespace: biological_process
def:
  "The process in which a monocyte expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex." [GOC:add, PMID:11200054]


id: GO:0002472
name: macrophage antigen processing and presentation
namespace: biological_process
def:
  "The process in which a macrophage expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex." [GOC:add, ISBN:0781735149, PMID:15771591]


id: GO:0002473
name: non-professional antigen presenting cell antigen processing and presentation
namespace: biological_process
def:
  "The process in which a non-professional antigen presenting cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex. Non-professional antigen presenting cells include all cell types but dendritic cells, B cells, T cells, monocytes, macrophages, and neutrophils." [GOC:add, ISBN:0781735149, PMID:15771591]


id: GO:0002474
name: antigen processing and presentation of peptide antigen via MHC class I
namespace: biological_process
def:
  "The process in which an antigen-presenting cell expresses a peptide antigen on its cell surface in association with an MHC class I protein complex. Class I here refers to classical class I molecules." [GOC:add, ISBN:0781735149, PMID:15224092, PMID:15771591]


id: GO:0002475
name: antigen processing and presentation via MHC class Ib
namespace: biological_process
def:
  "The process in which an antigen-presenting cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC class Ib protein complex. Class Ib here refers to non-classical class I molecules, such as those of the CD1 or HLA-E gene families." [GOC:add, PMID:15928678, PMID:15928680]


id: GO:0002476
name: antigen processing and presentation of endogenous peptide antigen via MHC class Ib
namespace: biological_process
def:
  "The process in which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC class Ib protein complex. The peptide is typically a fragment of a larger endogenous protein which has been degraded within the cell. Class Ib here refers to non-classical class I molecules, such as those of the HLA-E gene family." [GOC:add, PMID:15928678]


id: GO:0002477
name: antigen processing and presentation of exogenous peptide antigen via MHC class Ib
namespace: biological_process
def:
  "The process in which an antigen-presenting cell expresses a peptide antigen of exogenous origin on its cell surface in association with an MHC class Ib protein complex. The peptide is typically a fragment of a larger exogenous protein which has been degraded within the cell. Class Ib here refers to non-classical class I molecules, such as those of the HLA-E gene family." [GOC:add, PMID:15928678]


id: GO:0002478
name: antigen processing and presentation of exogenous peptide antigen
namespace: biological_process
def:
  "The process in which an antigen-presenting cell expresses a peptide antigen of exogenous origin on its cell surface in association with an MHC protein complex. The peptide is typically a fragment of a larger exogenous protein which has been degraded within the cell." [GOC:add, ISBN:0781735149]


id: GO:0002479
name: antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
namespace: biological_process
def:
  "The process in which an antigen-presenting cell expresses a peptide antigen of exogenous origin on its cell surface in association with an MHC class I protein complex following intracellular transport via a TAP (transporter associated with antigen processing) pathway. The peptide is typically a fragment of a larger exogenous protein which has been degraded within the cell and is dependent on TAP transport from the cytosol to ER for association with the MHC class I molecule. Class I here refers to classical class I molecules." [GOC:add, PMID:15224093, PMID:15771591, PMID:16181335]


id: GO:0002480
name: antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent
namespace: biological_process
def:
  "The process in which an antigen-presenting cell expresses a peptide antigen of exogenous origin on its cell surface in association with an MHC class I protein complex following intracellular transport via a pathway not requiring TAP (transporter associated with antigen processing). The peptide is typically a fragment of a larger exogenous protein which has been degraded within the cell. Class I here refers to classical class I molecules." [GOC:add, PMID:15224093, PMID:15771591, PMID:16181335]


id: GO:0002481
name: antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent
namespace: biological_process
def:
  "The process in which an antigen-presenting cell expresses a peptide antigen of exogenous origin on its cell surface in association with an MHC class Ib protein complex following intracellular transport via a TAP (transporter associated with antigen processing) pathway. The peptide is typically a fragment of a larger exogenous protein which has been degraded within the cell and is dependent on TAP transport from the cytosol to ER for association with the MHC class Ib molecule. Class Ib here refers to non-classical class I molecules, such as those of the HLA-E gene family." [GOC:add, PMID:15928678]


id: GO:0002482
name: antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-independent
namespace: biological_process
def:
  "The process in which an antigen-presenting cell expresses a peptide antigen of exogenous origin on its cell surface in association with an MHC class Ib protein complex following intracellular transport via a pathway not requiring TAP (transporter associated with antigen processing). The peptide is typically a fragment of a larger exogenous protein which has been degraded within the cell. Class Ib here refers to non-classical class I molecules, such as those of the HLA-E gene family." [GOC:add, PMID:15928678]


id: GO:0002483
name: antigen processing and presentation of endogenous peptide antigen
namespace: biological_process
def:
  "The process in which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC protein complex. The peptide is typically a fragment of a larger endogenous protein which has been degraded within the cell." [GOC:add, ISBN:0781735149]


id: GO:0002484
name: antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway
namespace: biological_process
def:
  "The process in which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC class I protein complex following intracellular transport via an ER pathway. The peptide is typically a fragment of a larger endogenous protein which has been degraded within the cell and becomes associated with the MHC class I molecule in the ER. Class I here refers to classical class I molecules." [GOC:add, ISBN:0781735149, PMID:14647477, PMID:15771591]


id: GO:0002485
namespace: biological_process
name:
  antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent

def:
  "The process in which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC class I protein complex following intracellular transport via a TAP-dependent ER pathway. The peptide is typically a fragment of a larger endogenous protein which has been degraded within the cell and becomes associated with the MHC class I molecule in the ER following TAP-dependent transport from the cytosol. Class I here refers to classical class I molecules." [GOC:add, ISBN:0781735149, PMID:14647477, PMID:15771591]


id: GO:0002486
namespace: biological_process
name:
  antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent

def:
  "The process in which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC class I protein complex following intracellular transport via a TAP-independent ER pathway. The peptide is typically a fragment of a larger endogenous protein which has been degraded within the cell and becomes associated with the MHC class I molecule in the ER following transport from the cytosol via a TAP-independent pathway. Class I here refers to classical class I molecules." [GOC:add, PMID:14647477, PMID:15771591]


id: GO:0002487
namespace: biological_process
name:
  antigen processing and presentation of endogenous peptide antigen via MHC class I via endolysosomal pathway

def:
  "The process in which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC class I protein complex. The peptide is typically a fragment of a larger endogenous protein which has been degraded within the cell and becomes associated with the MHC class I molecule in an endolysosome. Class I here refers to classical class I molecules." [GOC:add, PMID:10631943]


id: GO:0002488
name: antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway
namespace: biological_process
def:
  "The process in which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC class Ib protein complex following intracellular transport via an ER pathway. The peptide is typically a fragment of a larger endogenous protein which has been degraded within the cell and becomes associated with the MHC class Ib molecule in the ER. Class Ib here refers to non-classical class I molecules, such as those of the HLA-E gene family." [GOC:add, PMID:15928678]


id: GO:0002489
namespace: biological_process
name:
  antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent

def:
  "The process in which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC class Ib protein complex following intracellular transport via a TAP (transporter associated with antigen processing) pathway. The peptide is typically a fragment of a larger endogenous protein which has been degraded within the cell and is dependent on TAP transport from the cytosol to ER for association with the MHC class Ib molecule. Class Ib here refers to non-classical class I molecules, such as those of the HLA-E gene family." [GOC:add, PMID:15928678]


id: GO:0002490
namespace: biological_process
name:
  antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-independent

def:
  "The process in which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC class Ib protein complex following intracellular transport via a pathway not requiring TAP (transporter associated with antigen processing). The peptide is typically a fragment of a larger endogenous protein which has been degraded within the cell. Class Ib here refers to non-classical class I molecules, such as those of the HLA-E gene family." [GOC:add, PMID:15928678]


id: GO:0002491
name: antigen processing and presentation of endogenous peptide antigen via MHC class II
namespace: biological_process
def:
  "The process in which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC class II protein complex. The peptide antigen is typically, but not always, processed from a whole protein." [GOC:add, PMID:15531770, PMID:16181338]


id: GO:0002492
name: peptide antigen assembly with MHC class Ib protein complex
namespace: biological_process
def:
  "The binding of a peptide antigen to the antigen binding groove of an MHC class Ib protein complex. Class Ib here refers to non-classical class I molecules, such as those of the HLA-E gene family." [GOC:add, PMID:15928678]


id: GO:0002493
name: lipid antigen assembly with MHC class Ib protein complex
namespace: biological_process
def:
  "The binding of a lipid antigen to the antigen binding groove of an MHC class Ib protein complex. Class Ib here refers to non-classical class I molecules, such as those of the CD1 gene family." [GOC:add, PMID:15928678, PMID:15928680]


id: GO:0002494
name: lipid antigen transport
namespace: biological_process
def:
  "The directed movement of a lipid antigen into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:add, PMID:15928678, PMID:15928680]


id: GO:0002495
name: antigen processing and presentation of peptide antigen via MHC class II
namespace: biological_process
def:
  "The process in which an antigen-presenting cell expresses a peptide antigen on its cell surface in association with an MHC class II protein complex. The peptide antigen is typically, but not always, processed from a whole protein." [GOC:add, ISBN:0781735149, PMID:15531770, PMID:15771591]


id: GO:0002496
name: proteolysis associated with antigen processing and presentation
namespace: biological_process
def:
  "The hydrolysis of a peptide bond or bonds within a protein contributing to antigen processing and presentation." [GOC:add, ISBN:0781735149, PMID:15224092, PMID:15771591]


id: GO:0002497
name: proteasomal proteolysis associated with antigen processing and presentation
namespace: biological_process
def:
  "The hydrolysis of a peptide bond or bonds within a protein by the proteasome complex contributing to antigen processing and presentation." [GOC:add, ISBN:0781735149, PMID:15224092, PMID:15771591]


id: GO:0002498
name: proteolysis within endoplasmic reticulum associated with antigen processing and presentation
namespace: biological_process
def:
  "The hydrolysis of a peptide bond or bonds within a protein by ER resident proteases contributing to antigen processing and presentation." [GOC:add, ISBN:0781735149, PMID:15224092, PMID:15771591]


id: GO:0002499
name: proteolysis within endosome associated with antigen processing and presentation
namespace: biological_process
def:
  "The hydrolysis of a peptide bond or bonds within a protein by endosomal resident proteases contributing to antigen processing and presentation." [GOC:add, ISBN:0781735149, PMID:15771591]


id: GO:0002500
name: proteolysis within lysosome associated with antigen processing and presentation
namespace: biological_process
def:
  "The hydrolysis of a peptide bond or bonds within a protein by lysosomal resident proteases contributing to antigen processing and presentation." [GOC:add, ISBN:0781735149, PMID:15771591]


id: GO:0002501
name: peptide antigen assembly with MHC protein complex
namespace: biological_process
def:
  "The binding of a peptide to the antigen binding groove of an MHC protein complex." [GOC:add, ISBN:0781735149, PMID:15771591]


id: GO:0002502
name: peptide antigen assembly with MHC class I protein complex
namespace: biological_process
def:
  "The binding of a peptide to the antigen binding groove of an MHC class I protein complex. Class I here refers to classical class I molecules." [GOC:add, ISBN:0781735149, PMID:15771591]


id: GO:0002503
name: peptide antigen assembly with MHC class II protein complex
namespace: biological_process
def:
  "The binding of a peptide to the antigen binding groove of an MHC class II protein complex." [GOC:add, ISBN:0781735149, PMID:15771591]


id: GO:0002504
name: antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
namespace: biological_process
def:
  "The process in which an antigen-presenting cell expresses antigen (peptide or polysaccharide) on its cell surface in association with an MHC class II protein complex." [GOC:add, ISBN:0781735149, PMID:15531770, PMID:15771591, PMID:16153240]


id: GO:0002505
name: antigen processing and presentation of polysaccharide antigen via MHC class II
namespace: biological_process
def:
  "The process in which an antigen-presenting cell expresses a polysaccharide antigen on its cell surface in association with an MHC class II protein complex." [GOC:add, PMID:16153240]


id: GO:0002506
name: polysaccharide assembly with MHC class II protein complex
namespace: biological_process
def:
  "The binding of a polysaccharide to the antigen binding groove of an MHC class II protein complex." [GOC:add, PMID:16153240]


id: GO:0002507
name: tolerance induction
namespace: biological_process
def:
  "A process that directly activates any of the steps required for tolerance, a physiologic state in which the immune system does not react destructively against the components of an organism that harbors it or against antigens that are introduced to it." [GO_REF:0000022, GOC:jal, GOC:mtg_15nov05, ISBN:0781735149]


id: GO:0002508
name: central tolerance induction
namespace: biological_process
def:
  "Tolerance induction in the central lymphoid organs: the thymus and bone marrow." [GO_REF:0000022, GOC:jal, GOC:mtg_15nov05, ISBN:0781735149]


id: GO:0002509
name: central tolerance induction to self antigen
namespace: biological_process
def:
  "Tolerance induction in the central lymphoid organs directed at self antigens." [GOC:jal, ISBN:0781735149, PMID:16460922]


id: GO:0002513
name: tolerance induction to self antigen
namespace: biological_process
def:
  "Tolerance induction directed at self antigens." [GO_REF:0000022, GOC:jal, GOC:mtg_15nov05, ISBN:0781735149]


id: GO:0002514
name: B cell tolerance induction
namespace: biological_process
def:
  "A process involving any mechanism for tolerance induction in B cells." [GOC:jal, ISBN:0781735149, PMID:16460922]


id: GO:0002515
name: B cell anergy
namespace: biological_process
def:
  "Any process contributing to anergy in B cells, a state of functional inactivation which is part of B cell tolerance induction." [GOC:jal, ISBN:0781735149]


id: GO:0002516
name: B cell deletion
namespace: biological_process
def:
  "The apoptotic death of B cells which is part of B cell tolerance induction." [GOC:add, GOC:jal, ISBN:0781735149]


id: GO:0002517
name: T cell tolerance induction
namespace: biological_process
def:
  "A process involving any mechanism for tolerance induction in T cells." [GOC:jal, ISBN:0781735149, PMID:16551263]


id: GO:0002518
name: lymphocyte chemotaxis across high endothelial venule
namespace: biological_process
def:
  "The movement of a lymphocyte to cross a high endothelial venule in response to an external stimulus." [GOC:add, ISBN:0781735149, PMID:15122201]


id: GO:0002520
name: immune system development
namespace: biological_process
def:
  "The process whose specific outcome is the progression of an organismal system whose objective is to provide calibrated responses by an organism to a potential internal or invasive threat, over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process." [GOC:add, GOC:dph]


id: GO:0002521
name: leukocyte differentiation
namespace: biological_process
def:
  "The process in which a relatively unspecialized hemopoietic precursor cell acquires the specialized features of a leukocyte. A leukocyte is an achromatic cell of the myeloid or lymphoid lineages capable of ameboid movement, found in blood or other tissue." [CL:0000738, GOC:add, PMID:16551264]


id: GO:0002522
name: leukocyte migration involved in immune response
namespace: biological_process
def:
  "The movement of a leukocyte within or between different tissues and organs of the body as part of an immune response." [GOC:add, ISBN:0781735149, PMID:14680625, PMID:14708592, PMID:7507411, PMID:8600538]


id: GO:0002523
name: leukocyte migration involved in inflammatory response
namespace: biological_process
def:
  "The movement of a leukocyte within or between different tissues and organs of the body contributing to an inflammatory response." [GOC:add, ISBN:0781735149, PMID:14680625, PMID:14708592, PMID:7507411, PMID:8600538]


id: GO:0002524
name: hypersensitivity
namespace: biological_process
def:
  "An inflammatory response to an exogenous environmental antigen or an endogenous antigen initiated by the adaptive immune system." [GOC:jal, ISBN:0781735149]


id: GO:0002525
name: acute inflammatory response to non-antigenic stimulus
namespace: biological_process
def:
  "An acute inflammatory response to non-antigenic stimuli such as heat or physical trauma." [GOC:jal, PMID:16459497, PMID:9073326]


id: GO:0002526
name: acute inflammatory response
namespace: biological_process
def:
  "Inflammation which comprises a rapid, short-lived, relatively uniform response to acute injury or antigenic challenge and is characterized by accumulations of fluid, plasma proteins, and granulocytic leukocytes. An acute inflammatory response occurs within a matter of minutes or hours, and either resolves within a few days or becomes a chronic inflammatory response." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:0781735149]


id: GO:0002527
name: vasodilation involved in acute inflammatory response
namespace: biological_process
def:
  "An increase in the internal diameter of blood vessels, especially arterioles or capillaries, usually resulting in a decrease in blood pressure contributing to an acute inflammatory response." [GOC:jal]


id: GO:0002528
name: regulation of vascular permeability involved in acute inflammatory response
namespace: biological_process
def:
  "Any process that modulates the extent to which blood vessels can be pervaded by fluid contributing to an acute inflammatory response." [GOC:jal]


id: GO:0002529
name: regulation of plasma kallikrein-kinin cascade
namespace: biological_process
def:
  "Any process that modulates the frequency, rate, or extent of the plasma kallikrein-kinin cascade." [GOC:add]


id: GO:0002530
name: regulation of systemic arterial blood pressure involved in acute-phase response
namespace: biological_process
def:
  "Any process that modulates the force with which blood travels through the circulatory system that contributes to the acute phase response. The acute phase response occurs during the early phases of an infection and is marked by changes in the production of plasma proteins such as C-reactive protein." [GOC:jal, ISBN:081533642X]


id: GO:0002531
name: regulation of heart contraction involved in acute-phase response
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of heart contraction that contributes to the acute phase response. The acute phase response occurs during the early phases of an infection and is marked by changes in the production of plasma proteins such as C-reactive protein." [GOC:jal, PMID:15642986, PMID:15834430]


id: GO:0002532
name: production of molecular mediator involved in inflammatory response
namespace: biological_process
def:
  "The synthesis or release of any molecular mediator of the inflammatory response following an inflammatory stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:add, GOC:dph, GOC:tb, ISBN:0781735149]


id: GO:0002533
name: lysosomal enzyme secretion involved in inflammatory response
namespace: biological_process
def:
  "The regulated release of lysosomal enzymes by a cell as part of an inflammatory response." [GOC:jal, PMID:11836514]


id: GO:0002534
name: cytokine production involved in inflammatory response
namespace: biological_process
def:
  "The synthesis or release of a cytokine following a inflammatory stimulus as part of an inflammatory response, resulting in an increase in its intracellular or extracellular levels." [GOC:add, ISBN:0781735149]


id: GO:0002535
name: platelet activating factor secretion involved in inflammatory response
namespace: biological_process
def:
  "The regulated release of platelet activating factor by a cell as part of an inflammatory response." [GOC:add, ISBN:0781735149]


id: GO:0002536
name: respiratory burst involved in inflammatory response
namespace: biological_process
def:
  "A phase of elevated metabolic activity, during which oxygen consumption increases following a stimulus as part of an inflammatory response; this leads to the production, by an NADH dependent system, of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals, resulting in an increase in their intracellular or extracellular levels." [GOC:add, ISBN:0781735149]


id: GO:0002537
name: nitric oxide production involved in inflammatory response
namespace: biological_process
def:
  "The synthesis or release of nitric oxide following a stimulus as part of an inflammatory response, resulting in an increase in its intracellular or extracellular levels." [GOC:add, ISBN:0781735149]


id: GO:0002538
name: arachidonic acid metabolite production involved in inflammatory response
namespace: biological_process
def:
  "The synthesis or release of products of arachidonic acid metabolism following a stimulus as part of an inflammatory response, resulting in an increase in their intracellular or extracellular levels." [GOC:add, ISBN:0781735149]


id: GO:0002539
name: prostaglandin production involved in inflammatory response
namespace: biological_process
def:
  "The synthesis or release of any prostaglandin following a stimulus as part of an inflammatory response, resulting in an increase in its intracellular or extracellular levels." [GOC:add, ISBN:0781735149]


id: GO:0002540
name: leukotriene production involved in inflammatory response
namespace: biological_process
def:
  "The synthesis or release of any leukotriene following a stimulus as part of an inflammatory response, resulting in an increase in its intracellular or extracellular levels." [GOC:add, ISBN:0781735149]


id: GO:0002541
name: activation of plasma proteins involved in acute inflammatory response
namespace: biological_process
def:
  "Any process activating plasma proteins by proteolysis as part of an acute inflammatory response." [GOC:jal, ISBN:0781735149]


id: GO:0002542
name: Factor XII activation
namespace: biological_process
def:
  "Any process that activates Factor XII (Hageman factor). Factor XII is a protein synthesized by the liver that circulates in an inactive form until it encounters collagen or basement membrane or activated platelets (as occurs at the site of endothelial injury). Factor XII then undergoes a conformational change (becoming factor XIIa), exposing an active serine center that can subsequently cleave protein substrates and activate a variety of mediator systems. Factor XII is a participant in the clotting cascade as well as the kinin cascade." [GOC:jal, ISBN:0721601871]


id: GO:0002543
name: activation of blood coagulation via clotting cascade
namespace: biological_process
def:
  "Any process that initiates the clotting cascade of blood coagulation, a cascade of plasma enzymes that is triggered following damage to blood vessels, leading to formation of a clot." [GOC:jal, ISBN:0781735149]


id: GO:0002544
name: chronic inflammatory response
namespace: biological_process
def:
  "Inflammation of prolonged duration (weeks or months) in which active inflammation, tissue destruction, and attempts at repair are proceeding simultaneously. Although it may follow acute inflammation, chronic inflammation frequently begins insidiously, as a low-grade, smoldering, often asymptomatic response." [GO_REF:0000022, GOC:jal, GOC:mtg_15nov05, ISBN:0781735149]


id: GO:0002545
name: chronic inflammatory response to non-antigenic stimulus
namespace: biological_process
def:
  "A chronic inflammatory response to a non-antigenic stimulus such as heat or physical trauma." [GOC:jal]


id: GO:0002546
name: negative regulation of tissue kallikrein-kinin cascade
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate, or extent of the tissue kallikrein-kinin cascade." [GOC:add]


id: GO:0002547
name: positive regulation of tissue kallikrein-kinin cascade
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate, or extent of the tissue kallikrein-kinin cascade." [GOC:add]


id: GO:0002548
name: monocyte chemotaxis
namespace: biological_process
def:
  "The movement of a monocyte in response to an external stimulus." [GOC:add, PMID:11696603, PMID:15173832]


id: GO:0002549
name: negative regulation of plasma kallikrein-kinin cascade
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate, or extent of the plasma kallikrein-kinin cascade." [GOC:add]


id: GO:0002550
name: positive regulation of plasma kallikrein-kinin cascade
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate, or extent of the plasma kallikrein-kinin cascade." [GOC:add]


id: GO:0002551
name: mast cell chemotaxis
namespace: biological_process
def:
  "The movement of a mast cell in response to an external stimulus." [GOC:add, PMID:11292027, PMID:12789214, PMID:16448392]


id: GO:0002552
name: serotonin secretion by mast cell
namespace: biological_process
def:
  "The regulated release of serotonin by a mast cell or group of mast cells." [GOC:add, ISBN:0781735149]


id: GO:0002553
name: histamine secretion by mast cell
namespace: biological_process
def:
  "The regulated release of histamine by a mast cell or group of mast cells." [GOC:add, ISBN:0781735149]


id: GO:0002554
name: serotonin secretion by platelet
namespace: biological_process
def:
  "The regulated release of serotonin by a platelet or group of platelets." [GOC:add, ISBN:0781735149]


id: GO:0002556
name: serotonin secretion by basophil
namespace: biological_process
def:
  "The regulated release of serotonin by a basophil or group of basophils." [GOC:add, ISBN:0781735149]


id: GO:0002557
name: histamine secretion by basophil
namespace: biological_process
def:
  "The regulated release of histamine by a basophil or group of basophils." [GOC:add, ISBN:0781735149]


id: GO:0002558
name: type I hypersensitivity mediated by mast cells
namespace: biological_process
def:
  "An inflammatory response driven by antigen recognition by antibodies bound to Fc receptors on mast cells, occurring within minutes after exposure of a sensitized individual to the antigen, and leading to the release of a variety of inflammatory mediators such as histamines." [GOC:add, ISBN:0781735149]


id: GO:0002559
name: type I hypersensitivity mediated by basophils
namespace: biological_process
def:
  "An inflammatory response driven by antigen recognition by antibodies bound to Fc receptors basophils, occurring within minutes after exposure of a sensitized individual to the antigen, and leading to the release of a variety of inflammatory mediators such as histamines." [GOC:add, ISBN:0781735149]


id: GO:0002560
name: basophil mediated immunity
namespace: biological_process
def:
  "Any process involved in the carrying out of an immune response by a basophil." [GOC:add, ISBN:0781735149]


id: GO:0002561
name: basophil degranulation
namespace: biological_process
def:
  "The regulated exocytosis of secretory granules containing preformed mediators such as histamine, serotonin, and neutral proteases by a basophil." [GOC:add, ISBN:0781735149]


id: GO:0002562
name: somatic diversification of immune receptors via germline recombination within a single locus
namespace: biological_process
def:
  "The process in which immune receptor genes are diversified through recombination of the germline genetic elements within a single genetic locus." [GOC:add, ISBN:0781735149, PMID:16102575, PMID:16166509]


id: GO:0002563
name: somatic diversification of immune receptors via alternate splicing
namespace: biological_process
def:
  "The process in which immune receptor genes are diversified through alternate splicing." [GOC:add, ISBN:0781735149, PMID:16166509]


id: GO:0002564
name: alternate splicing of immunoglobulin genes
namespace: biological_process
def:
  "The generation of alternate transcripts of immunoglobulin genes through alternate splicing of exons." [ISBN:0781735149, PMID:9185563]


id: GO:0002565
name: somatic diversification of immune receptors via gene conversion
namespace: biological_process
def:
  "The process in which immune receptor genes are diversified through gene conversion." [GOC:add, ISBN:0781735149]


id: GO:0002566
name: somatic diversification of immune receptors via somatic mutation
namespace: biological_process
def:
  "The process in which immune receptor genes are diversified through somatic mutation." [ISBN:0781735149, PMID:16102575]


id: GO:0002567
name: somatic diversification of FREP-based immune receptors
namespace: biological_process
def:
  "The process that results in the generation of sequence diversity of the FREP-based immune receptors of snails." [GOC:add, PMID:16102575]


id: GO:0002568
name: somatic diversification of T cell receptor genes
namespace: biological_process
def:
  "The somatic process that results in the generation of sequence diversity of T cell receptor genes." [GOC:add, ISBN:0781735149]


id: GO:0002569
name: somatic diversification of immune receptors by N region addition
namespace: biological_process
def:
  "The addition of variable numbers of random nucleotides by terminal deoxytransferase in the N regions of heavy chain immunoglobulin and T cell receptor genes. N regions are found at the V-D, D-D, V-J, and D-J recombinational junctions, depending on the immune receptor gene." [GOC:add, ISBN:0781735149]


id: GO:0002570
name: somatic diversification of immunoglobulin genes by N region addition
namespace: biological_process
def:
  "The addition of variable numbers of random nucleotides by terminal deoxytransferase in the N regions of heavy chain immunoglobulin genes. N regions are found at the V-D and D-J recombinational junctions." [GOC:add, ISBN:0781735149]


id: GO:0002571
name: somatic diversification of T cell receptor genes by N region addition
namespace: biological_process
def:
  "The addition of variable numbers of random nucleotides by terminal deoxytransferase in the N regions of T cell receptor genes. N regions are found at the V-D, D-D, V-J, and D-J recombinational junctions, depending on the T cell receptor gene." [GOC:add, ISBN:0781735149]


id: GO:0002572
name: pro-T cell differentiation
namespace: biological_process
def:
  "The process in which a precursor cell type acquires the specialized features of a pro-T cell. Pro-T cells are the earliest stage of the T cell lineage but are not fully committed." [GOC:add, ISBN:0781735149]


id: GO:0002573
name: myeloid leukocyte differentiation
namespace: biological_process
def:
  "The process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of any cell of the myeloid leukocyte lineage." [GOC:add, PMID:16551251]


id: GO:0002574
name: thrombocyte differentiation
namespace: biological_process
def:
  "The process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of a thrombocyte, a nucleated cell found in all vertebrates but mammals involved in hemostasis." [GOC:add]


id: GO:0002576
name: platelet degranulation
namespace: biological_process
def:
  "The regulated exocytosis of secretory granules containing preformed mediators such as histamine and serotonin by a platelet." [GOC:add]


id: GO:0002577
name: regulation of antigen processing and presentation
namespace: biological_process
def:
  "Any process that modulates the frequency, rate, or extent of antigen processing and presentation." [GOC:add]


id: GO:0002578
name: negative regulation of antigen processing and presentation
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate, or extent of antigen processing and presentation." [GOC:add]


id: GO:0002579
name: positive regulation of antigen processing and presentation
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate, or extent of antigen processing and presentation." [GOC:add]


id: GO:0002580
namespace: biological_process
name:
  regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II

def:
  "Any process that modulates the frequency, rate, or extent of antigen processing and presentation of antigen (peptide or polysaccharide) via MHC class II." [GOC:add]


id: GO:0002581
namespace: biological_process
name:
  negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II

def:
  "Any process that stops, prevents, or reduces the frequency, rate, or extent of antigen processing and presentation of antigen (peptide or polysaccharide) via MHC class II." [GOC:add]


id: GO:0002582
namespace: biological_process
name:
  positive regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II

def:
  "Any process that activates or increases the frequency, rate, or extent of antigen processing and presentation of antigen (peptide or polysaccharide) via MHC class II." [GOC:add]


id: GO:0002583
name: regulation of antigen processing and presentation of peptide antigen
namespace: biological_process
def:
  "Any process that modulates the frequency, rate, or extent of antigen processing and presentation of peptide antigen." [GOC:add]


id: GO:0002584
name: negative regulation of antigen processing and presentation of peptide antigen
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate, or extent of antigen processing and presentation of peptide antigen." [GOC:add]


id: GO:0002585
name: positive regulation of antigen processing and presentation of peptide antigen
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate, or extent of antigen processing and presentation of peptide antigen." [GOC:add]


id: GO:0002586
name: regulation of antigen processing and presentation of peptide antigen via MHC class II
namespace: biological_process
def:
  "Any process that modulates the frequency, rate, or extent of antigen processing and presentation of peptide antigen via MHC class II." [GOC:add]


id: GO:0002587
name: negative regulation of antigen processing and presentation of peptide antigen via MHC class II
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate, or extent of antigen processing and presentation of peptide antigen via MHC class II." [GOC:add]


id: GO:0002588
name: positive regulation of antigen processing and presentation of peptide antigen via MHC class II
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate, or extent of antigen processing and presentation of peptide antigen via MHC class II." [GOC:add]


id: GO:0002589
name: regulation of antigen processing and presentation of peptide antigen via MHC class I
namespace: biological_process
def:
  "Any process that modulates the frequency, rate, or extent of antigen processing and presentation of peptide antigen via MHC class I." [GOC:add]


id: GO:0002590
name: negative regulation of antigen processing and presentation of peptide antigen via MHC class I
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate, or extent of antigen processing and presentation of peptide antigen via MHC class I." [GOC:add]


id: GO:0002591
name: positive regulation of antigen processing and presentation of peptide antigen via MHC class I
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate, or extent of antigen processing and presentation of peptide antigen via MHC class I." [GOC:add]


id: GO:0002592
name: regulation of antigen processing and presentation via MHC class Ib
namespace: biological_process
def:
  "Any process that modulates the frequency, rate, or extent of antigen processing and presentation of antigen via MHC class Ib." [GOC:add]


id: GO:0002593
name: negative regulation of antigen processing and presentation via MHC class Ib
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate, or extent of antigen processing and presentation of antigen via MHC class Ib." [GOC:add]


id: GO:0002594
name: positive regulation of antigen processing and presentation via MHC class Ib
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate, or extent of antigen processing and presentation of antigen via MHC class Ib." [GOC:add]


id: GO:0002595
name: regulation of antigen processing and presentation of peptide antigen via MHC class Ib
namespace: biological_process
def:
  "Any process that modulates the frequency, rate, or extent of antigen processing and presentation of peptide antigen via MHC class Ib." [GOC:add]


id: GO:0002596
name: negative regulation of antigen processing and presentation of peptide antigen via MHC class Ib
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate, or extent of antigen processing and presentation of peptide antigen via MHC class Ib." [GOC:add]


id: GO:0002597
name: positive regulation of antigen processing and presentation of peptide antigen via MHC class Ib
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate, or extent of antigen processing and presentation of peptide antigen via MHC class Ib." [GOC:add]


id: GO:0002598
name: regulation of antigen processing and presentation of lipid antigen via MHC class Ib
namespace: biological_process
def:
  "Any process that modulates the frequency, rate, or extent of antigen processing and presentation of lipid antigen via MHC class Ib." [GOC:add]


id: GO:0002599
name: negative regulation of antigen processing and presentation of lipid antigen via MHC class Ib
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate, or extent of antigen processing and presentation of lipid antigen via MHC class Ib." [GOC:add]


id: GO:0002600
name: positive regulation of antigen processing and presentation of lipid antigen via MHC class Ib
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate, or extent of antigen processing and presentation of lipid antigen via MHC class Ib." [GOC:add]


id: GO:0002601
name: regulation of antigen processing and presentation of polysaccharide antigen via MHC class II
namespace: biological_process
def:
  "Any process that modulates the frequency, rate, or extent of antigen processing and presentation of polysaccharide antigen via MHC class II." [GOC:add]


id: GO:0002602
namespace: biological_process
name:
  negative regulation of antigen processing and presentation of polysaccharide antigen via MHC class II

def:
  "Any process that stops, prevents, or reduces the frequency, rate, or extent of antigen processing and presentation of polysaccharide antigen via MHC class II." [GOC:add]


id: GO:0002603
namespace: biological_process
name:
  positive regulation of antigen processing and presentation of polysaccharide antigen via MHC class II

def:
  "Any process that activates or increases the frequency, rate, or extent of antigen processing and presentation of polysaccharide antigen via MHC class II." [GOC:add]


id: GO:0002604
name: regulation of dendritic cell antigen processing and presentation
namespace: biological_process
def:
  "Any process that modulates the frequency, rate, or extent of dendritic cell antigen processing and presentation." [GOC:add]


id: GO:0002605
name: negative regulation of dendritic cell antigen processing and presentation
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate, or extent of dendritic cell antigen processing and presentation." [GOC:add]


id: GO:0002606
name: positive regulation of dendritic cell antigen processing and presentation
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate, or extent of dendritic cell antigen processing and presentation." [GOC:add]


id: GO:0002607
name: regulation of myeloid dendritic cell antigen processing and presentation
namespace: biological_process
def:
  "Any process that modulates the frequency, rate, or extent of myeloid dendritic cell antigen processing and presentation." [GOC:add]


id: GO:0002608
name: negative regulation of myeloid dendritic cell antigen processing and presentation
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate, or extent of myeloid dendritic cell antigen processing and presentation." [GOC:add]


id: GO:0002609
name: positive regulation of myeloid dendritic cell antigen processing and presentation
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate, or extent of myeloid dendritic cell antigen processing and presentation." [GOC:add]


id: GO:0002610
name: regulation of plasmacytoid dendritic cell antigen processing and presentation
namespace: biological_process
def:
  "Any process that modulates the frequency, rate, or extent of plasmacytoid dendritic cell antigen processing and presentation." [GOC:add]


id: GO:0002611
name: negative regulation of plasmacytoid dendritic cell antigen processing and presentation
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate, or extent of plasmacytoid dendritic cell antigen processing and presentation." [GOC:add]


id: GO:0002612
name: positive regulation of plasmacytoid dendritic cell antigen processing and presentation
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate, or extent of plasmacytoid dendritic cell antigen processing and presentation." [GOC:add]


id: GO:0002613
name: regulation of monocyte antigen processing and presentation
namespace: biological_process
def:
  "Any process that modulates the frequency, rate, or extent of monocyte antigen processing and presentation." [GOC:add]


id: GO:0002614
name: negative regulation of monocyte antigen processing and presentation
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate, or extent of monocyte antigen processing and presentation." [GOC:add]


id: GO:0002615
name: positive regulation of monocyte antigen processing and presentation
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate, or extent of monocyte antigen processing and presentation." [GOC:add]


id: GO:0002616
name: regulation of macrophage antigen processing and presentation
namespace: biological_process
def:
  "Any process that modulates the frequency, rate, or extent of macrophage antigen processing and presentation." [GOC:add]


id: GO:0002617
name: negative regulation of macrophage antigen processing and presentation
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate, or extent of macrophage antigen processing and presentation." [GOC:add]


id: GO:0002618
name: positive regulation of macrophage antigen processing and presentation
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate, or extent of macrophage antigen processing and presentation." [GOC:add]


id: GO:0002619
name: regulation of non-professional antigen presenting cell antigen processing and presentation
namespace: biological_process
def:
  "Any process that modulates the frequency, rate, or extent of non-professional antigen presenting cell antigen processing and presentation." [GOC:add]


id: GO:0002620
name: negative regulation of non-professional antigen presenting cell antigen processing and presentation
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate, or extent of non-professional antigen presenting cell antigen processing and presentation." [GOC:add]


id: GO:0002621
name: positive regulation of non-professional antigen presenting cell antigen processing and presentation
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate, or extent of non-professional antigen presenting cell antigen processing and presentation." [GOC:add]


id: GO:0002622
name: regulation of B cell antigen processing and presentation
namespace: biological_process
def:
  "Any process that modulates the frequency, rate, or extent of B cell antigen processing and presentation." [GOC:add]


id: GO:0002623
name: negative regulation of B cell antigen processing and presentation
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate, or extent of B cell antigen processing and presentation." [GOC:add]


id: GO:0002624
name: positive regulation of B cell antigen processing and presentation
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate, or extent of B cell antigen processing and presentation." [GOC:add]


id: GO:0002625
name: regulation of T cell antigen processing and presentation
namespace: biological_process
def:
  "Any process that modulates the frequency, rate, or extent of T cell antigen processing and presentation." [GOC:add]


id: GO:0002626
name: negative regulation of T cell antigen processing and presentation
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate, or extent of T cell antigen processing and presentation." [GOC:add]


id: GO:0002627
name: positive regulation of T cell antigen processing and presentation
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate, or extent of T cell antigen processing and presentation." [GOC:add]


id: GO:0002628
name: regulation of proteolysis associated with antigen processing and presentation
namespace: biological_process
def:
  "Any process that modulates the frequency, rate, or extent of proteolysis associated with antigen processing and presentation." [GOC:add]


id: GO:0002629
name: negative regulation of proteolysis associated with antigen processing and presentation
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate, or extent of proteolysis associated with antigen processing and presentation." [GOC:add]


id: GO:0002630
name: positive regulation of proteolysis associated with antigen processing and presentation
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate, or extent of proteolysis associated with antigen processing and presentation." [GOC:add]


id: GO:0002632
name: negative regulation of granuloma formation
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate, or extent of granuloma formation." [GOC:add]


id: GO:0002633
name: positive regulation of granuloma formation
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate, or extent of granuloma formation." [GOC:add]


id: GO:0002635
name: negative regulation of germinal center formation
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate, or extent of germinal center formation." [GOC:add]


id: GO:0002636
name: positive regulation of germinal center formation
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate, or extent of germinal center formation." [GOC:add]


id: GO:0002638
name: negative regulation of immunoglobulin production
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate, or extent of immunoglobulin production." [GOC:add]


id: GO:0002639
name: positive regulation of immunoglobulin production
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate, or extent of immunoglobulin production." [GOC:add]


id: GO:0002640
name: regulation of immunoglobulin biosynthetic process
namespace: biological_process
def:
  "Any process that modulates the frequency, rate, or extent of immunoglobulin biosynthesis." [GOC:add]


id: GO:0002641
name: negative regulation of immunoglobulin biosynthetic process
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate, or extent of immunoglobulin biosynthesis." [GOC:add]


id: GO:0002642
name: positive regulation of immunoglobulin biosynthetic process
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate, or extent of immunoglobulin biosynthesis." [GOC:add]


id: GO:0002644
name: negative regulation of tolerance induction
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate, or extent of tolerance induction." [GOC:add]


id: GO:0002645
name: positive regulation of tolerance induction
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate, or extent of tolerance induction." [GOC:add]


id: GO:0002646
name: regulation of central tolerance induction
namespace: biological_process
def:
  "Any process that modulates the frequency, rate, or extent of central tolerance induction." [GOC:add]


id: GO:0002647
name: negative regulation of central tolerance induction
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate, or extent of central tolerance induction." [GOC:add]


id: GO:0002648
name: positive regulation of central tolerance induction
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate, or extent of central tolerance induction." [GOC:add]


id: GO:0002649
name: regulation of tolerance induction to self antigen
namespace: biological_process
def:
  "Any process that modulates the frequency, rate, or extent of tolerance induction to self antigen." [GOC:add]


id: GO:0002650
name: negative regulation of tolerance induction to self antigen
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate, or extent of tolerance induction to self antigen." [GOC:add]


id: GO:0002651
name: positive regulation of tolerance induction to self antigen
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate, or extent of tolerance induction to self antigen." [GOC:add]


id: GO:0002652
name: regulation of tolerance induction dependent upon immune response
namespace: biological_process
def:
  "Any process that modulates the frequency, rate, or extent of tolerance induction dependent upon immune response." [GOC:add]


id: GO:0002653
name: negative regulation of tolerance induction dependent upon immune response
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate, or extent of tolerance induction dependent upon immune response." [GOC:add]


id: GO:0002654
name: positive regulation of tolerance induction dependent upon immune response
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate, or extent of tolerance induction dependent upon immune response." [GOC:add]


id: GO:0002655
name: regulation of tolerance induction to nonself antigen
namespace: biological_process
def:
  "Any process that modulates the frequency, rate, or extent of tolerance induction to nonself antigen." [GOC:add]


id: GO:0002656
name: negative regulation of tolerance induction to nonself antigen
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate, or extent of tolerance induction to nonself antigen." [GOC:add]


id: GO:0002657
name: positive regulation of tolerance induction to nonself antigen
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate, or extent of tolerance induction to nonself antigen." [GOC:add]


id: GO:0002658
name: regulation of peripheral tolerance induction
namespace: biological_process
def:
  "Any process that modulates the frequency, rate, or extent of peripheral tolerance induction." [GOC:add]


id: GO:0002659
name: negative regulation of peripheral tolerance induction
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate, or extent of peripheral tolerance induction." [GOC:add]


id: GO:0002660
name: positive regulation of peripheral tolerance induction
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate, or extent of peripheral tolerance induction." [GOC:add]


id: GO:0002661
name: regulation of B cell tolerance induction
namespace: biological_process
def:
  "Any process that modulates the frequency, rate, or extent of B cell tolerance induction." [GOC:add]


id: GO:0002662
name: negative regulation of B cell tolerance induction
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate, or extent of B cell tolerance induction." [GOC:add]


id: GO:0002663
name: positive regulation of B cell tolerance induction
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate, or extent of B cell tolerance induction." [GOC:add]


id: GO:0002664
name: regulation of T cell tolerance induction
namespace: biological_process
def:
  "Any process that modulates the frequency, rate, or extent of T cell tolerance induction." [GOC:add]


id: GO:0002665
name: negative regulation of T cell tolerance induction
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate, or extent of T cell tolerance induction." [GOC:add]


id: GO:0002666
name: positive regulation of T cell tolerance induction
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate, or extent of T cell tolerance induction." [GOC:add]


id: GO:0002668
name: negative regulation of T cell anergy
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate, or extent of T cell anergy." [GOC:add]


id: GO:0002669
name: positive regulation of T cell anergy
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate, or extent of T cell anergy." [GOC:add]


id: GO:0002671
name: negative regulation of B cell anergy
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate, or extent of B cell anergy." [GOC:add]


id: GO:0002672
name: positive regulation of B cell anergy
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate, or extent of B cell anergy." [GOC:add]


id: GO:0002673
name: regulation of acute inflammatory response
namespace: biological_process
def:
  "Any process that modulates the frequency, rate, or extent of an acute inflammatory response." [GOC:add]


id: GO:0002674
name: negative regulation of acute inflammatory response
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate, or extent of an acute inflammatory response." [GOC:add]


id: GO:0002675
name: positive regulation of acute inflammatory response
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate, or extent of an acute inflammatory response." [GOC:add]


id: GO:0002676
name: regulation of chronic inflammatory response
namespace: biological_process
def:
  "Any process that modulates the frequency, rate, or extent of a chronic inflammatory response." [GOC:add]


id: GO:0002677
name: negative regulation of chronic inflammatory response
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate, or extent of a chronic inflammatory response." [GOC:add]


id: GO:0002678
name: positive regulation of chronic inflammatory response
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate, or extent of a chronic inflammatory response." [GOC:add]


id: GO:0002679
name: respiratory burst involved in defense response
namespace: biological_process
def:
  "A phase of elevated metabolic activity, during which oxygen consumption increases made as part of a defense response ; this leads to the production, by an NADH dependent system, of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals." [GOC:add, ISBN:0781735149, PMID:12789499]


id: GO:0002680
name: pro-T cell lineage commitment
namespace: biological_process
def:
  "The process in which a lymphoid progenitor cell becomes committed to becoming a pro-T cell." [GOC:add, ISBN:0781735149]


id: GO:0002681
name: somatic recombination of T cell receptor gene segments
namespace: biological_process
def:
  "The process in which T cell receptor genes are formed through recombination of the germline genetic elements, also known as T cell receptor gene segments." [GOC:add, ISBN:0781735149]


id: GO:0002683
name: negative regulation of immune system process
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate, or extent of an immune system process." [GOC:add]


id: GO:0002684
name: positive regulation of immune system process
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate, or extent of an immune system process." [GOC:add]


id: GO:0002686
name: negative regulation of leukocyte migration
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate, or extent of leukocyte migration." [GOC:add]


id: GO:0002687
name: positive regulation of leukocyte migration
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate, or extent of leukocyte migration." [GOC:add]


id: GO:0002689
name: negative regulation of leukocyte chemotaxis
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate, or extent of leukocyte chemotaxis." [GOC:add]


id: GO:0002690
name: positive regulation of leukocyte chemotaxis
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate, or extent of leukocyte chemotaxis." [GOC:add]


id: GO:0002692
name: negative regulation of cellular extravasation
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate, or extent of cellular extravasation." [GOC:add]


id: GO:0002693
name: positive regulation of cellular extravasation
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate, or extent of cellular extravasation." [GOC:add]


id: GO:0002695
name: negative regulation of leukocyte activation
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate, or extent of leukocyte activation." [GOC:add]


id: GO:0002696
name: positive regulation of leukocyte activation
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate, or extent of leukocyte activation." [GOC:add]


id: GO:0002697
name: regulation of immune effector process
namespace: biological_process
def:
  "Any process that modulates the frequency, rate, or extent of an immune effector process." [GOC:add]


id: GO:0002698
name: negative regulation of immune effector process
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate, or extent of an immune effector process." [GOC:add]


id: GO:0002699
name: positive regulation of immune effector process
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate, or extent of an immune effector process." [GOC:add]


id: GO:0002700
name: regulation of production of molecular mediator of immune response
namespace: biological_process
def:
  "Any process that modulates the frequency, rate, or extent of the production of molecular mediator of immune response." [GOC:add]


id: GO:0002701
name: negative regulation of production of molecular mediator of immune response
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate, or extent of the production of molecular mediator of immune response." [GOC:add]


id: GO:0002702
name: positive regulation of production of molecular mediator of immune response
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate, or extent of the production of molecular mediator of immune response." [GOC:add]


id: GO:0002703
name: regulation of leukocyte mediated immunity
namespace: biological_process
def:
  "Any process that modulates the frequency, rate, or extent of leukocyte mediated immunity." [GOC:add]


id: GO:0002704
name: negative regulation of leukocyte mediated immunity
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate, or extent of leukocyte mediated immunity." [GOC:add]


id: GO:0002705
name: positive regulation of leukocyte mediated immunity
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate, or extent of leukocyte mediated immunity." [GOC:add]


id: GO:0002706
name: regulation of lymphocyte mediated immunity
namespace: biological_process
def:
  "Any process that modulates the frequency, rate, or extent of lymphocyte mediated immunity." [GOC:add]


id: GO:0002707
name: negative regulation of lymphocyte mediated immunity
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate, or extent of lymphocyte mediated immunity." [GOC:add]


id: GO:0002708
name: positive regulation of lymphocyte mediated immunity
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate, or extent of lymphocyte mediated immunity." [GOC:add]


id: GO:0002710
name: negative regulation of T cell mediated immunity
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate, or extent of T cell mediated immunity." [GOC:add]


id: GO:0002711
name: positive regulation of T cell mediated immunity
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate, or extent of T cell mediated immunity." [GOC:add]


id: GO:0002713
name: negative regulation of B cell mediated immunity
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate, or extent of B cell mediated immunity." [GOC:add]


id: GO:0002714
name: positive regulation of B cell mediated immunity
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate, or extent of B cell mediated immunity." [GOC:add]


id: GO:0002715
name: regulation of natural killer cell mediated immunity
namespace: biological_process
def:
  "Any process that modulates the frequency, rate, or extent of natural killer cell mediated immunity." [GOC:add]


id: GO:0002716
name: negative regulation of natural killer cell mediated immunity
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate, or extent of natural killer cell mediated immunity." [GOC:add]


id: GO:0002717
name: positive regulation of natural killer cell mediated immunity
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate, or extent of natural killer cell mediated immunity." [GOC:add]


id: GO:0002718
name: regulation of cytokine production involved in immune response
namespace: biological_process
def:
  "Any process that modulates the frequency, rate, or extent of cytokine production that contributes to an immune response." [GOC:add]


id: GO:0002719
name: negative regulation of cytokine production involved in immune response
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate, or extent of cytokine production contributing to an immune response." [GOC:add]


id: GO:0002720
name: positive regulation of cytokine production involved in immune response
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate, or extent of cytokine production that contributes to an immune response." [GOC:add]


id: GO:0002721
name: regulation of B cell cytokine production
namespace: biological_process
def:
  "Any process that modulates the frequency, rate, or extent of B cell cytokine production." [GOC:add]


id: GO:0002722
name: negative regulation of B cell cytokine production
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate, or extent of B cell cytokine production." [GOC:add]


id: GO:0002723
name: positive regulation of B cell cytokine production
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate, or extent of B cell cytokine production." [GOC:add]


id: GO:0002724
name: regulation of T cell cytokine production
namespace: biological_process
def:
  "Any process that modulates the frequency, rate, or extent of T cell cytokine production." [GOC:add]


id: GO:0002725
name: negative regulation of T cell cytokine production
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate, or extent of T cell cytokine production." [GOC:add]


id: GO:0002726
name: positive regulation of T cell cytokine production
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate, or extent of T cell cytokine production." [GOC:add]


id: GO:0002727
name: regulation of natural killer cell cytokine production
namespace: biological_process
def:
  "Any process that modulates the frequency, rate, or extent of natural killer cell cytokine production." [GOC:add]


id: GO:0002728
name: negative regulation of natural killer cell cytokine production
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate, or extent of natural killer cell cytokine production." [GOC:add]


id: GO:0002729
name: positive regulation of natural killer cell cytokine production
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate, or extent of natural killer cell cytokine production." [GOC:add]


id: GO:0002730
name: regulation of dendritic cell cytokine production
namespace: biological_process
def:
  "Any process that modulates the frequency, rate, or extent of dendritic cell cytokine production." [GOC:add]


id: GO:0002731
name: negative regulation of dendritic cell cytokine production
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate, or extent of dendritic cell cytokine production." [GOC:add]


id: GO:0002732
name: positive regulation of dendritic cell cytokine production
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate, or extent of dendritic cell cytokine production." [GOC:add]


id: GO:0002733
name: regulation of myeloid dendritic cell cytokine production
namespace: biological_process
def:
  "Any process that modulates the frequency, rate, or extent of myeloid dendritic cell cytokine production." [GOC:add]


id: GO:0002734
name: negative regulation of myeloid dendritic cell cytokine production
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate, or extent of myeloid dendritic cell cytokine production." [GOC:add]


id: GO:0002735
name: positive regulation of myeloid dendritic cell cytokine production
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate, or extent of myeloid dendritic cell cytokine production." [GOC:add]


id: GO:0002736
name: regulation of plasmacytoid dendritic cell cytokine production
namespace: biological_process
def:
  "Any process that modulates the frequency, rate, or extent of plasmacytoid dendritic cell cytokine production." [GOC:add]


id: GO:0002737
name: negative regulation of plasmacytoid dendritic cell cytokine production
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate, or extent of plasmacytoid dendritic cell cytokine production." [GOC:add]


id: GO:0002738
name: positive regulation of plasmacytoid dendritic cell cytokine production
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate, or extent of plasmacytoid dendritic cell cytokine production." [GOC:add]


id: GO:0002739
name: regulation of cytokine secretion involved in immune response
namespace: biological_process
def:
  "Any process that modulates the frequency, rate, or extent of cytokine secretion contributing to an immune response." [GOC:add]


id: GO:0002740
name: negative regulation of cytokine secretion involved in immune response
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate, or extent of cytokine secretion contributing to an immune response." [GOC:add]


id: GO:0002741
name: positive regulation of cytokine secretion involved in immune response
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate, or extent of cytokine secretion contributing to an immune response." [GOC:add]


id: GO:0002742
name: regulation of cytokine biosynthetic process involved in immune response
namespace: biological_process
def:
  "Any process that modulates the frequency, rate, or extent of cytokine biosynthesis that contributes to an immune response." [GOC:add]


id: GO:0002743
name: negative regulation of cytokine biosynthetic process involved in immune response
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate, or extent of cytokine biosynthesis contributing to an immune response." [GOC:add]


id: GO:0002744
name: positive regulation of cytokine biosynthetic process involved in immune response
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate, or extent of cytokine biosynthesis contributing to an immune response." [GOC:add]


id: GO:0002745
name: antigen processing and presentation initiated by receptor mediated uptake of antigen
namespace: biological_process
def:
  "Antigen processing and presentation which is initiated by uptake of antigen bound to a cell surface receptor." [GOC:add, ISBN:0781735149]


id: GO:0002746
name: antigen processing and presentation following pinocytosis
namespace: biological_process
def:
  "Antigen processing and presentation which is initiated by uptake of antigen via pinocytosis." [GOC:add, ISBN:0781735149]


id: GO:0002747
name: antigen processing and presentation following phagocytosis
namespace: biological_process
def:
  "Antigen processing and presentation which is initiated by uptake of antigen via phagocytosis." [GOC:add, ISBN:0781735149]


id: GO:0002748
namespace: biological_process
name:
  antigen processing and presentation initiated by pattern recognition receptor mediated uptake of antigen

def:
  "Antigen processing and presentation which is initiated by uptake of antigen bound to a cell surface pattern recognition receptor (PRR)." [GOC:add, ISBN:0781735149]


id: GO:0002749
namespace: biological_process
name:
  antigen processing and presentation initiated by toll-like receptor mediated phagocytosis of antigen

def:
  "Antigen processing and presentation which is initiated by phagocytosis of antigen bound directly or indirectly to a cell surface toll-like receptor (TLR)." [GOC:add, ISBN:0781735149, PMID:15596122]


id: GO:0002750
name: antigen processing and presentation following macropinocytosis
namespace: biological_process
def:
  "Antigen processing and presentation which is initiated by uptake of antigen via macropinocytosis." [GOC:add, PMID:16556257]


id: GO:0002751
name: antigen processing and presentation following receptor mediated endocytosis
namespace: biological_process
def:
  "Antigen processing and presentation which is initiated by uptake of antigen receptor-mediated endocytosis." [GOC:add, ISBN:0781735149]


id: GO:0002752
name: cell surface pattern recognition receptor signaling pathway
namespace: biological_process
def:
  "Any series of molecular signals generated as a consequence of a cell surface pattern recognition receptor (PRR) binding to one of its physiological ligands. PRRs bind pathogen-associated molecular pattern (PAMPs), structures conserved among microbial species, or damage-associated molecular pattern (DAMPs), endogenous molecules released from damaged cells." [GOC:add, GOC:ar, ISBN:0781735149, PMID:15199967]


id: GO:0002753
name: cytoplasmic pattern recognition receptor signaling pathway
namespace: biological_process
def:
  "Any series of molecular signals generated as a consequence of a cytoplasmic pattern recognition receptor (PRR) binding to one of its physiological ligands. PRRs bind pathogen-associated molecular pattern (PAMPs), structures conserved among microbial species, or damage-associated molecular pattern (DAMPs), endogenous molecules released from damaged cells." [GOC:add, GOC:ar, ISBN:0781735149, PMID:15199967]


id: GO:0002754
name: intracellular vesicle pattern recognition receptor signaling pathway
namespace: biological_process
def:
  "Any series of molecular signals generated as a consequence of an intracellular vesicle pattern recognition receptor (PRR) binding to one of its physiological ligands. PRRs bind pathogen-associated molecular pattern (PAMPs), structures conserved among microbial species, or damage-associated molecular pattern (DAMPs), endogenous molecules released from damaged cells." [GOC:add, GOC:ar, ISBN:0781735149, PMID:15199967]


id: GO:0002755
name: MyD88-dependent toll-like receptor signaling pathway
namespace: biological_process
def:
  "Any series of molecular signals generated as a consequence of binding to a toll-like receptor where the MyD88 adaptor molecule mediates transduction of the signal. Toll-like receptors directly bind pattern motifs from a variety of microbial sources to initiate innate immune response." [GOC:add, ISBN:0781735149, PMID:12467241, PMID:12524386, PMID:12855817, PMID:15585605, PMID:15728447]


id: GO:0002756
name: MyD88-independent toll-like receptor signaling pathway
namespace: biological_process
def:
  "Any series of molecular signals generated as a consequence of binding to a toll-like receptor not relying on the MyD88 adaptor molecule. Toll-like receptors directly bind pattern motifs from a variety of microbial sources to initiate innate immune response." [GOC:add, ISBN:0781735149, PMID:12467241, PMID:12524386, PMID:12855817, PMID:15585605, PMID:15728447]


id: GO:0002757
name: immune response-activating signal transduction
namespace: biological_process
def:
  "The cascade of processes by which a signal interacts with a receptor, causing a change in the level or activity of a second messenger or other downstream target, and ultimately leading to activation or perpetuation of an immune response." [GOC:add]


id: GO:0002758
name: innate immune response-activating signal transduction
namespace: biological_process
def:
  "The cascade of processes by which a signal interacts with a receptor, causing a change in the level or activity of a second messenger or other downstream target, and ultimately leading to activation or perpetuation of an innate immune response." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05]


id: GO:0002759
name: regulation of antimicrobial humoral response
namespace: biological_process
def:
  "Any process that modulates the frequency, rate, or extent of an antimicrobial humoral response." [GOC:add]


id: GO:0002760
name: positive regulation of antimicrobial humoral response
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate, or extent of an antimicrobial humoral response." [GOC:add]


id: GO:0002761
name: regulation of myeloid leukocyte differentiation
namespace: biological_process
def:
  "Any process that modulates the frequency, rate, or extent of myeloid leukocyte differentiation." [GOC:add]


id: GO:0002762
name: negative regulation of myeloid leukocyte differentiation
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate, or extent of myeloid leukocyte differentiation." [GOC:add]


id: GO:0002763
name: positive regulation of myeloid leukocyte differentiation
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate, or extent of myeloid leukocyte differentiation." [GOC:add]


id: GO:0002764
name: immune response-regulating signaling pathway
namespace: biological_process
def:
  "The cascade of processes by which a signal interacts with a receptor, causing a change in the level or activity of a second messenger or other downstream target, and ultimately leading to the activation, perpetuation, or inhibition of an immune response." [GOC:add, ISBN:0781735149, PMID:15771571]


id: GO:0002765
name: immune response-inhibiting signal transduction
namespace: biological_process
def:
  "The cascade of processes by which a signal interacts with a receptor, causing a change in the level or activity of a second messenger or other downstream target, and ultimately leading to inhibition of an immune response." [GOC:add, ISBN:0781735149]


id: GO:0002766
name: innate immune response-inhibiting signal transduction
namespace: biological_process
def:
  "The cascade of processes by which a signal interacts with a receptor, causing a change in the level or activity of a second messenger or other downstream target, and ultimately leading to inhibition of an innate immune response." [GOC:add, ISBN:0781735149, PMID:15771571]


id: GO:0002767
name: immune response-inhibiting cell surface receptor signaling pathway
namespace: biological_process
def:
  "A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell capable of inhibiting an immune response." [GOC:add, ISBN:0781735149, PMID:15771571]


id: GO:0002768
name: immune response-regulating cell surface receptor signaling pathway
namespace: biological_process
def:
  "A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell capable of activating, perpetuating, or inhibiting an immune response." [GOC:add, ISBN:0781735149, PMID:15771571]


id: GO:0002769
name: natural killer cell inhibitory signaling pathway
namespace: biological_process
def:
  "A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of a natural killer cell capable of inhibiting an immune effector process contributing to an immune response." [GOC:add, ISBN:0781735149, PMID:15771571]


id: GO:0002770
name: T cell inhibitory signaling pathway
namespace: biological_process
def:
  "A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of a T cell capable of inhibiting an immune effector process contributing to an immune response." [GOC:add, PMID:15258309]


id: GO:0002771
name: inhibitory killer cell immunoglobulin-like receptor signaling pathway
namespace: biological_process
def:
  "A series of molecular signals initiated by the binding of an extracellular ligand to a inhibitory killer cell immunoglobulin-like receptor capable of inhibiting an immune effector process contributing to an immune response." [GOC:add, ISBN:0781735149, PMID:15771571]


id: GO:0002772
name: inhibitory C-type lectin receptor signaling pathway
namespace: biological_process
def:
  "A series of molecular signals initiated by the binding of an extracellular ligand to an inhibitory C-type lectin receptor capable of inhibiting an immune effector process contributing to an immune response." [GOC:add, ISBN:0781735149, PMID:15771571]


id: GO:0002773
name: B cell inhibitory signaling pathway
namespace: biological_process
def:
  "A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of a B cell capable of inhibiting an immune effector process contributing to an immune response." [GOC:add, PMID:16413920]


id: GO:0002774
name: Fc receptor mediated inhibitory signaling pathway
namespace: biological_process
def:
  "A series of molecular signals generated as a consequence of the binding of the Fc portion of an immunoglobulin by an Fc receptor capable of inhibiting an immune effector process contributing to an immune response. The Fc portion of an immunoglobulin is its C-terminal constant region." [GOC:add, ISBN:0781735149]


id: GO:0002775
name: antimicrobial peptide production
namespace: biological_process
def:
  "The synthesis or release of an antimicrobial peptide during an immune response, resulting in an increase in intracellular or extracellular levels. Such peptides may have protective properties against bacteria, fungi, viruses, or protozoa." [GOC:add, ISBN:0781735149, PMID:11807545, PMID:15638771]


id: GO:0002776
name: antimicrobial peptide secretion
namespace: biological_process
def:
  "The regulated release of an antimicrobial peptide from a cell or a tissue. Such peptides may have protective properties against bacteria, fungi, viruses, or protozoa." [GOC:add, ISBN:0781735149, PMID:11807545, PMID:15638771]


id: GO:0002777
name: antimicrobial peptide biosynthetic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of an antimicrobial peptide. Such peptides may have protective properties against bacteria, fungi, viruses, or protozoa." [GOC:add, ISBN:0781735149, PMID:11807545, PMID:15638771]


id: GO:0002778
name: antibacterial peptide production
namespace: biological_process
def:
  "The synthesis or release of an antibacterial peptide during an immune response, resulting in an increase in intracellular or extracellular levels." [GOC:add, ISBN:0781735149, PMID:11807545, PMID:15638771]


id: GO:0002779
name: antibacterial peptide secretion
namespace: biological_process
def:
  "The regulated release of an antibacterial peptide from a cell or a tissue." [GOC:add, ISBN:0781735149, PMID:11807545, PMID:15638771]


id: GO:0002780
name: antibacterial peptide biosynthetic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of an antibacterial peptide." [GOC:add, ISBN:0781735149, PMID:11807545, PMID:15638771]


id: GO:0002781
name: antifungal peptide production
namespace: biological_process
def:
  "The synthesis or release of an antifungal peptide during an immune response, resulting in an increase in intracellular or extracellular levels." [GOC:add, ISBN:0781735149, PMID:11807545, PMID:15638771]


id: GO:0002782
name: antifungal peptide secretion
namespace: biological_process
def:
  "The regulated release of an antifungal peptide from a cell or a tissue." [GOC:add, ISBN:0781735149, PMID:11807545, PMID:15638771]


id: GO:0002783
name: antifungal peptide biosynthetic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of an antifungal peptide." [GOC:add, ISBN:0781735149, PMID:11807545, PMID:15638771]


id: GO:0002784
name: regulation of antimicrobial peptide production
namespace: biological_process
def:
  "Any process that modulates the frequency, rate, or extent of antimicrobial peptide production." [GOC:add]


id: GO:0002785
name: negative regulation of antimicrobial peptide production
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate, or extent of antimicrobial peptide production." [GOC:add]


id: GO:0002786
name: regulation of antibacterial peptide production
namespace: biological_process
def:
  "Any process that modulates the frequency, rate, or extent of antibacterial peptide production." [GOC:add]


id: GO:0002787
name: negative regulation of antibacterial peptide production
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate, or extent of antibacterial peptide production." [GOC:add]


id: GO:0002788
name: regulation of antifungal peptide production
namespace: biological_process
def:
  "Any process that modulates the frequency, rate, or extent of antifungal peptide production." [GOC:add]


id: GO:0002789
name: negative regulation of antifungal peptide production
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate, or extent of antifungal peptide production." [GOC:add]


id: GO:0002792
name: negative regulation of peptide secretion
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate, or extent of peptide secretion." [GOC:add]


id: GO:0002793
name: positive regulation of peptide secretion
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate, or extent of peptide secretion." [GOC:add]


id: GO:0002794
name: regulation of antimicrobial peptide secretion
namespace: biological_process
def:
  "Any process that modulates the frequency, rate, or extent of antimicrobial peptide secretion." [GOC:add]


id: GO:0002795
name: negative regulation of antimicrobial peptide secretion
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate, or extent of antimicrobial peptide secretion." [GOC:add]


id: GO:0002796
name: positive regulation of antimicrobial peptide secretion
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate, or extent of antimicrobial peptide secretion." [GOC:add]


id: GO:0002797
name: regulation of antibacterial peptide secretion
namespace: biological_process
def:
  "Any process that modulates the frequency, rate, or extent of antibacterial peptide secretion." [GOC:add]


id: GO:0002798
name: negative regulation of antibacterial peptide secretion
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate, or extent of antibacterial peptide secretion." [GOC:add]


id: GO:0002799
name: positive regulation of antibacterial peptide secretion
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate, or extent of antibacterial peptide secretion." [GOC:add]


id: GO:0002800
name: regulation of antifungal peptide secretion
namespace: biological_process
def:
  "Any process that modulates the frequency, rate, or extent of antifungal peptide secretion." [GOC:add]


id: GO:0002801
name: negative regulation of antifungal peptide secretion
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate, or extent of antifungal peptide secretion." [GOC:add]


id: GO:0002802
name: positive regulation of antifungal peptide secretion
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate, or extent of antifungal peptide secretion." [GOC:add]


id: GO:0002803
name: positive regulation of antibacterial peptide production
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate, or extent of antibacterial peptide production." [GOC:add]


id: GO:0002804
name: positive regulation of antifungal peptide production
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate, or extent of antifungal peptide production." [GOC:add]


id: GO:0002805
name: regulation of antimicrobial peptide biosynthetic process
namespace: biological_process
def:
  "Any process that modulates the frequency, rate, or extent of antimicrobial peptide biosynthesis." [GOC:add]


id: GO:0002806
name: negative regulation of antimicrobial peptide biosynthetic process
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate, or extent of antimicrobial peptide biosynthesis." [GOC:add]


id: GO:0002807
name: positive regulation of antimicrobial peptide biosynthetic process
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate, or extent of antimicrobial peptide biosynthesis." [GOC:add]


id: GO:0002808
name: regulation of antibacterial peptide biosynthetic process
namespace: biological_process
def:
  "Any process that modulates the frequency, rate, or extent of antibacterial peptide biosynthesis." [GOC:add]


id: GO:0002809
name: negative regulation of antibacterial peptide biosynthetic process
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate, or extent of antibacterial peptide biosynthesis." [GOC:add]


id: GO:0002810
name: regulation of antifungal peptide biosynthetic process
namespace: biological_process
def:
  "Any process that modulates the frequency, rate, or extent of antifungal peptide biosynthesis." [GOC:add]


id: GO:0002811
name: negative regulation of antifungal peptide biosynthetic process
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate, or extent of antifungal peptide biosynthesis." [GOC:add]


id: GO:0002812
name: biosynthetic process of antibacterial peptides active against Gram-negative bacteria
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of an antibacterial peptide with activity against Gram-negative bacteria." [GOC:add, PMID:11807545]


id: GO:0002813
name: regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria
namespace: biological_process
def:
  "Any process that modulates the frequency, rate, or extent of biosynthesis of antibacterial peptides active against Gram-negative bacteria." [GOC:add]


id: GO:0002814
namespace: biological_process
name:
  negative regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria

def:
  "Any process that stops, prevents, or reduces the frequency, rate, or extent of biosynthesis of antibacterial peptides active against Gram-negative bacteria." [GOC:add]


id: GO:0002815
name: biosynthetic process of antibacterial peptides active against Gram-positive bacteria
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of an antibacterial peptide with activity against Gram-positive bacteria." [GOC:add]


id: GO:0002816
name: regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria
namespace: biological_process
def:
  "Any process that modulates the frequency, rate, or extent of biosynthesis of antibacterial peptides active against Gram-positive bacteria." [GOC:add]


id: GO:0002817
namespace: biological_process
name:
  negative regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria

def:
  "Any process that stops, prevents, or reduces the frequency, rate, or extent of biosynthesis of antibacterial peptides active against Gram-positive bacteria." [GOC:add]


id: GO:0002819
name: regulation of adaptive immune response
namespace: biological_process
def:
  "Any process that modulates the frequency, rate, or extent of an adaptive immune response." [GOC:add]


id: GO:0002820
name: negative regulation of adaptive immune response
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate, or extent of an adaptive immune response." [GOC:add]


id: GO:0002821
name: positive regulation of adaptive immune response
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate, or extent of an adaptive immune response." [GOC:add]


id: GO:0002822
namespace: biological_process
name:
  regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains

def:
  "Any process that modulates the frequency, rate, or extent of an adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains. An example of this process is found in the Gnathostomata." [GOC:add, GOC:mtg_sensu]


id: GO:0002823
namespace: biological_process
name:
  negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains

def:
  "Any process that stops, prevents, or reduces the frequency, rate, or extent of an adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains. An example of this process is found in the Gnathostomata." [GOC:add, GOC:mtg_sensu]


id: GO:0002824
namespace: biological_process
name:
  positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains

def:
  "Any process that activates or increases the frequency, rate, or extent of an adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains. An example of this process is found in the Gnathostomata." [GOC:add, GOC:mtg_sensu]


id: GO:0002825
name: regulation of T-helper 1 type immune response
namespace: biological_process
def:
  "Any process that modulates the frequency, rate, or extent of a T-helper 1 type immune response." [GOC:add]


id: GO:0002826
name: negative regulation of T-helper 1 type immune response
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate, or extent of a T-helper 1 type immune response." [GOC:add]


id: GO:0002827
name: positive regulation of T-helper 1 type immune response
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate, or extent of a T-helper 1 type immune response." [GOC:add]


id: GO:0002829
name: negative regulation of type 2 immune response
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate, or extent of a type 2 immune response." [GOC:add]


id: GO:0002830
name: positive regulation of type 2 immune response
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate, or extent of a type 2 immune response." [GOC:add]


id: GO:0002831
name: regulation of response to biotic stimulus
namespace: biological_process
def:
  "Any process that modulates the frequency, rate, or extent of a response to biotic stimulus." [GOC:add]


id: GO:0002832
name: negative regulation of response to biotic stimulus
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate, or extent of a response to biotic stimulus." [GOC:add]


id: GO:0002833
name: positive regulation of response to biotic stimulus
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate, or extent of a response to biotic stimulus." [GOC:add]


id: GO:0002835
name: negative regulation of response to tumor cell
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate, or extent of a response to tumor cell." [GOC:add]


id: GO:0002836
name: positive regulation of response to tumor cell
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate, or extent of a response to tumor cell." [GOC:add]


id: GO:0002837
name: regulation of immune response to tumor cell
namespace: biological_process
def:
  "Any process that modulates the frequency, rate, or extent of an immune response to tumor cell." [GOC:add]


id: GO:0002838
name: negative regulation of immune response to tumor cell
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate, or extent of an immune response to tumor cell." [GOC:add]


id: GO:0002839
name: positive regulation of immune response to tumor cell
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate, or extent of an immune response to tumor cell." [GOC:add]


id: GO:0002840
name: regulation of T cell mediated immune response to tumor cell
namespace: biological_process
def:
  "Any process that modulates the frequency, rate, or extent of a T cell mediated immune response to tumor cell." [GOC:add]


id: GO:0002841
name: negative regulation of T cell mediated immune response to tumor cell
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate, or extent of a T cell mediated immune response to tumor cell." [GOC:add]


id: GO:0002842
name: positive regulation of T cell mediated immune response to tumor cell
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate, or extent of a T cell mediated immune response to tumor cell." [GOC:add]


id: GO:0002843
name: regulation of tolerance induction to tumor cell
namespace: biological_process
def:
  "Any process that modulates the frequency, rate, or extent of tolerance induction to tumor cell." [GOC:add]


id: GO:0002844
name: negative regulation of tolerance induction to tumor cell
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate, or extent of tolerance induction to tumor cell." [GOC:add]


id: GO:0002845
name: positive regulation of tolerance induction to tumor cell
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate, or extent of tolerance induction to tumor cell." [GOC:add]


id: GO:0002846
name: regulation of T cell tolerance induction to tumor cell
namespace: biological_process
def:
  "Any process that modulates the frequency, rate, or extent of T cell tolerance induction to tumor cell." [GOC:add]


id: GO:0002847
name: negative regulation of T cell tolerance induction to tumor cell
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate, or extent of T cell tolerance induction to tumor cell." [GOC:add]


id: GO:0002848
name: positive regulation of T cell tolerance induction to tumor cell
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate, or extent of T cell tolerance induction to tumor cell." [GOC:add]


id: GO:0002849
name: regulation of peripheral T cell tolerance induction
namespace: biological_process
def:
  "Any process that modulates the frequency, rate, or extent of peripheral T cell tolerance induction." [GOC:add]


id: GO:0002850
name: negative regulation of peripheral T cell tolerance induction
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate, or extent of peripheral T cell tolerance induction." [GOC:add]


id: GO:0002851
name: positive regulation of peripheral T cell tolerance induction
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate, or extent of peripheral T cell tolerance induction." [GOC:add]


id: GO:0002852
name: regulation of T cell mediated cytotoxicity directed against tumor cell target
namespace: biological_process
def:
  "Any process that modulates the frequency, rate, or extent of T cell mediated cytotoxicity directed against a tumor cell target." [GOC:add]


id: GO:0002853
name: negative regulation of T cell mediated cytotoxicity directed against tumor cell target
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate, or extent of T cell mediated cytotoxicity directed against a tumor cell target." [GOC:add]


id: GO:0002854
name: positive regulation of T cell mediated cytotoxicity directed against tumor cell target
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate, or extent of T cell mediated cytotoxicity directed against a tumor cell target." [GOC:add]


id: GO:0002855
name: regulation of natural killer cell mediated immune response to tumor cell
namespace: biological_process
def:
  "Any process that modulates the frequency, rate, or extent of natural killer cell mediated immune response to a tumor cell." [GOC:add]


id: GO:0002856
name: negative regulation of natural killer cell mediated immune response to tumor cell
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate, or extent of natural killer cell mediated immune response to a tumor cell." [GOC:add]


id: GO:0002857
name: positive regulation of natural killer cell mediated immune response to tumor cell
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate, or extent of natural killer cell mediated immune response to a tumor cell." [GOC:add]


id: GO:0002858
name: regulation of natural killer cell mediated cytotoxicity directed against tumor cell target
namespace: biological_process
def:
  "Any process that modulates the frequency, rate, or extent of natural killer cell mediated cytotoxicity directed against tumor cell target." [GOC:add]


id: GO:0002859
name: negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate, or extent of natural killer cell mediated cytotoxicity directed against tumor cell target." [GOC:add]


id: GO:0002860
name: positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate, or extent of natural killer cell mediated cytotoxicity directed against tumor cell target." [GOC:add]


id: GO:0002861
name: regulation of inflammatory response to antigenic stimulus
namespace: biological_process
def:
  "Any process that modulates the frequency, rate, or extent of an inflammatory response to an antigenic stimulus." [GOC:add]


id: GO:0002862
name: negative regulation of inflammatory response to antigenic stimulus
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate, or extent of an inflammatory response to an antigenic stimulus." [GOC:add]


id: GO:0002863
name: positive regulation of inflammatory response to antigenic stimulus
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate, or extent of an inflammatory response to an antigenic stimulus." [GOC:add]


id: GO:0002864
name: regulation of acute inflammatory response to antigenic stimulus
namespace: biological_process
def:
  "Any process that modulates the frequency, rate, or extent of an acute inflammatory response to an antigenic stimulus." [GOC:add]


id: GO:0002865
name: negative regulation of acute inflammatory response to antigenic stimulus
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate, or extent of an acute inflammatory response to an antigenic stimulus." [GOC:add]


id: GO:0002866
name: positive regulation of acute inflammatory response to antigenic stimulus
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate, or extent of an acute inflammatory response to an antigenic stimulus." [GOC:add]


id: GO:0002868
name: negative regulation of B cell deletion
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate, or extent of B cell deletion." [GOC:add]


id: GO:0002869
name: positive regulation of B cell deletion
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate, or extent of B cell deletion." [GOC:add]


id: GO:0002870
name: T cell anergy
namespace: biological_process
def:
  "Any process contributing to anergy in T cells, a state of functional inactivation which is part of T cell tolerance induction." [GOC:add, ISBN:0781735149]


id: GO:0002871
name: regulation of natural killer cell tolerance induction
namespace: biological_process
def:
  "Any process that modulates the frequency, rate, or extent of natural killer cell tolerance induction." [GOC:add]


id: GO:0002872
name: negative regulation of natural killer cell tolerance induction
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate, or extent of natural killer cell tolerance induction." [GOC:add]


id: GO:0002873
name: positive regulation of natural killer cell tolerance induction
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate, or extent of natural killer cell tolerance induction." [GOC:add]


id: GO:0002874
name: regulation of chronic inflammatory response to antigenic stimulus
namespace: biological_process
def:
  "Any process that modulates the frequency, rate, or extent of a chronic inflammatory response to an antigenic stimulus." [GOC:add]


id: GO:0002875
name: negative regulation of chronic inflammatory response to antigenic stimulus
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate, or extent of a chronic inflammatory response to an antigenic stimulus." [GOC:add]


id: GO:0002876
name: positive regulation of chronic inflammatory response to antigenic stimulus
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate, or extent of a chronic inflammatory response to an antigenic stimulus." [GOC:add]


id: GO:0002877
name: regulation of acute inflammatory response to non-antigenic stimulus
namespace: biological_process
def:
  "Any process that modulates the frequency, rate, or extent of an acute inflammatory response to a non-antigenic stimulus." [GOC:add]


id: GO:0002878
name: negative regulation of acute inflammatory response to non-antigenic stimulus
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate, or extent of an acute inflammatory response to a non-antigenic stimulus." [GOC:add]


id: GO:0002879
name: positive regulation of acute inflammatory response to non-antigenic stimulus
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate, or extent of an acute inflammatory response to a non-antigenic stimulus." [GOC:add]


id: GO:0002880
name: regulation of chronic inflammatory response to non-antigenic stimulus
namespace: biological_process
def:
  "Any process that modulates the frequency, rate, or extent of a chronic inflammatory response to a non-antigenic stimulus." [GOC:add]


id: GO:0002881
name: negative regulation of chronic inflammatory response to non-antigenic stimulus
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate, or extent of a chronic inflammatory response to a non-antigenic stimulus." [GOC:add]


id: GO:0002882
name: positive regulation of chronic inflammatory response to non-antigenic stimulus
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate, or extent of a chronic inflammatory response to a non-antigenic stimulus." [GOC:add]


id: GO:0002884
name: negative regulation of hypersensitivity
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate, or extent of hypersensitivity." [GOC:add]


id: GO:0002885
name: positive regulation of hypersensitivity
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate, or extent of hypersensitivity." [GOC:add]


id: GO:0002886
name: regulation of myeloid leukocyte mediated immunity
namespace: biological_process
def:
  "Any process that modulates the frequency, rate, or extent of myeloid leukocyte mediated immunity." [GOC:add]


id: GO:0002887
name: negative regulation of myeloid leukocyte mediated immunity
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate, or extent of myeloid leukocyte mediated immunity." [GOC:add]


id: GO:0002888
name: positive regulation of myeloid leukocyte mediated immunity
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate, or extent of myeloid leukocyte mediated immunity." [GOC:add]


id: GO:0002889
name: regulation of immunoglobulin mediated immune response
namespace: biological_process
def:
  "Any process that modulates the frequency, rate, or extent of an immunoglobulin mediated immune response." [GOC:add]


id: GO:0002890
name: negative regulation of immunoglobulin mediated immune response
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate, or extent of an immunoglobulin mediated immune response." [GOC:add]


id: GO:0002891
name: positive regulation of immunoglobulin mediated immune response
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate, or extent of an immunoglobulin mediated immune response." [GOC:add]


id: GO:0002893
name: negative regulation of type II hypersensitivity
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate, or extent of type II hypersensitivity." [GOC:add]


id: GO:0002894
name: positive regulation of type II hypersensitivity
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate, or extent of type II hypersensitivity." [GOC:add]


id: GO:0002895
name: regulation of central B cell tolerance induction
namespace: biological_process
def:
  "Any process that modulates the frequency, rate, or extent of central B cell tolerance induction." [GOC:add]


id: GO:0002896
name: negative regulation of central B cell tolerance induction
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate, or extent of central B cell tolerance induction." [GOC:add]


id: GO:0002897
name: positive regulation of central B cell tolerance induction
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate, or extent of central B cell tolerance induction." [GOC:add]


id: GO:0002899
name: negative regulation of central B cell deletion
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate, or extent of central B cell deletion." [GOC:add]


id: GO:0002900
name: positive regulation of central B cell deletion
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate, or extent of central B cell deletion." [GOC:add]


id: GO:0002901
name: mature B cell apoptotic process
namespace: biological_process
def:
  "Any apoptotic process in a B cell that is mature, having left the bone marrow." [CL:0000785, GOC:add, GOC:mtg_apoptosis, ISBN:0781735149]


id: GO:0002902
name: regulation of B cell apoptotic process
namespace: biological_process
def:
  "Any process that modulates the frequency, rate, or extent of B cell apoptotic process." [GOC:add, GOC:mtg_apoptosis]


id: GO:0002903
name: negative regulation of B cell apoptotic process
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate, or extent of B cell apoptotic process." [GOC:add, GOC:mtg_apoptosis]


id: GO:0002904
name: positive regulation of B cell apoptotic process
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate, or extent of B cell apoptotic process." [GOC:add, GOC:mtg_apoptosis]


id: GO:0002905
name: regulation of mature B cell apoptotic process
namespace: biological_process
def:
  "Any process that modulates the frequency, rate, or extent of mature B cell apoptotic process." [GOC:add, GOC:mtg_apoptosis]


id: GO:0002906
name: negative regulation of mature B cell apoptotic process
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate, or extent of mature B cell apoptotic process." [GOC:add, GOC:mtg_apoptosis]


id: GO:0002907
name: positive regulation of mature B cell apoptotic process
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate, or extent of mature B cell apoptotic process." [GOC:add, GOC:mtg_apoptosis]


id: GO:0002908
name: regulation of peripheral B cell deletion
namespace: biological_process
def:
  "Any process that modulates the frequency, rate, or extent of peripheral B cell deletion." [GOC:add]


id: GO:0002909
name: negative regulation of peripheral B cell deletion
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate, or extent of peripheral B cell deletion." [GOC:add]


id: GO:0002910
name: positive regulation of peripheral B cell deletion
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate, or extent of peripheral B cell deletion." [GOC:add]


id: GO:0002912
name: negative regulation of lymphocyte anergy
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate, or extent of lymphocyte anergy." [GOC:add]


id: GO:0002913
name: positive regulation of lymphocyte anergy
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate, or extent of lymphocyte anergy." [GOC:add]


id: GO:0002915
name: negative regulation of central B cell anergy
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate, or extent of central B cell anergy." [GOC:add]


id: GO:0002916
name: positive regulation of central B cell anergy
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate, or extent of central B cell anergy." [GOC:add]


id: GO:0002918
name: negative regulation of peripheral B cell anergy
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate, or extent of peripheral B cell anergy." [GOC:add]


id: GO:0002919
name: positive regulation of peripheral B cell anergy
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate, or extent of peripheral B cell anergy." [GOC:add]


id: GO:0002921
name: negative regulation of humoral immune response
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate, or extent of a humoral immune response." [GOC:add]


id: GO:0002922
name: positive regulation of humoral immune response
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate, or extent of a humoral immune response." [GOC:add]


id: GO:0002923
name: regulation of humoral immune response mediated by circulating immunoglobulin
namespace: biological_process
def:
  "Any process that modulates the frequency, rate, or extent of a humoral immune response mediated by circulating immunoglobulin." [GOC:add]


id: GO:0002924
name: negative regulation of humoral immune response mediated by circulating immunoglobulin
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate, or extent of a humoral immune response mediated by circulating immunoglobulin." [GOC:add]


id: GO:0002925
name: positive regulation of humoral immune response mediated by circulating immunoglobulin
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate, or extent of a humoral immune response mediated by circulating immunoglobulin." [GOC:add]


id: GO:0002926
name: tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridine biosynthesis.
namespace: biological_process
def:
  "The process whereby a wobble base uridine residue in a tRNA is modified to 5-methoxycarbonylmethyl-2-thiouridine." [GOC:hjd, UniPathway:UPA00988]


id: GO:0002927
name: archaeosine-tRNA biosynthetic process
namespace: biological_process
def:
  "The chemical reactions and pathways involved in the biosynthesis of archaeosine, an archaea-specific modified base found at position 15 in the D-loop of certain archaeal tRNAs." [GOC:hjd, UniPathway:UPA00393]


id: GO:0002929
name: MECO complex
namespace: cellular_component
def:
  "A highly stable complex composed of the ATAC complex and the mediator complex (also called TRAP or MED). MECO binds and regulates the transcription of a subset of non-coding RNAs transcribed by RNA polymerase II." [GOC:hjd, PMID:20508642]


id: GO:0002930
name: trabecular meshwork development
namespace: biological_process
def:
  "The progression of the trabecular meshwork over time, from its formation to the mature structure. The trabecular meshwork is a fenestrated endothelial-like tissue situated at the intersection of the cornea and the iris. The trabecular meshwork provides drainage for the aqueous humor." [PMID:20568247]


id: GO:0002931
name: response to ischemia
namespace: biological_process
def:
  "Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a inadequate blood supply." [GOC:hjd]


id: GO:0002932
name: tendon sheath development
namespace: biological_process
def:
  "The process whose specific outcome is the progression of a tendon sheath over time, from its formation to the mature structure. A tendon sheath is a layer of membrane around a tendon. It permits the tendon to move." [PMID:20696843]


id: GO:0002933
name: lipid hydroxylation
namespace: biological_process
def:
  "The covalent attachment of a hydroxyl group to one or more fatty acids in a lipid." [GOC:hjd, PMID:15658937]


id: GO:0002934
name: desmosome organization
namespace: biological_process
def:
  "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a desmosome. A desmosome is a patch-like intercellular junction found in vertebrate tissues, consisting of parallel zones of two cell membranes, separated by an space of 25-35 nm, and having dense fibrillar plaques in the subjacent cytoplasm." [GOC:hjd]


id: GO:0002935
name: tRNA (adenine-C2-)-methyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 2 S-adenosyl-L-methionine + adenine(37) in tRNA = S-adenosyl-L-homocysteine + 5'-deoxyadenosine + L-methionine + C2-methyladenine(37) in a tRNA." [PMID:22891362]


id: GO:0002936
name: bradykinin biosynthetic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of the peptide hormone bradykinin." [PMID:11226291]


id: GO:0002937
name: tRNA 4-thiouridine biosynthesis
namespace: biological_process
def:
  "The processes whereby a uridine residue in a tRNA is converted to 4-thiouridine. Typically 4-thiouridine is found at position 8, in many transfer RNAs." [ISBN:155581073X]


id: GO:0002938
name: tRNA guanine ribose methylation
namespace: biological_process
def:
  "The process whereby a guanosine residue in a tRNA is methylated on the 2'-hydroxyl group of the ribose moiety." [ISBN:155581075X, ISBN:1555811337]


id: GO:0002939
name: tRNA N1-guanine methylation
namespace: biological_process
def:
  "The process whereby a guanine in tRNA is methylated at position N1 of the guanine." [ISBN:155581073X, ISBN:1555811337]


id: GO:0002940
name: tRNA N2-guanine methylation
namespace: biological_process
def:
  "The process whereby a guanine in a tRNA is methylated at the N2 position of guanine." [ISBN:155581073X, ISBN:1555811337]


id: GO:0002941
name: synoviocyte proliferation
namespace: biological_process
def:
  "The multiplication or reproduction of synoviocytes by cell division, resulting in the expansion of their population. A synoviocyte is a fibroblast-like cell found in synovial tissues." [CL:0000214, PMID:9546370]


id: GO:0002942
name: tRNA m2,2-guanine biosynthesis
namespace: biological_process
def:
  "The process whereby a guanine residue in a transfer RNA is methylated twice at the N2 position." [GOC:hjd, ISBN:1-55581-073-x]


id: GO:0002943
name: tRNA dihydrouridine synthesis
namespace: biological_process
def:
  "The process whereby a uridine in a transfer RNA is converted to dihydrouridine." [GOC:hjd, ISBN:1-55581-073-x]


id: GO:0002944
name: cyclin K-CDK12 complex
namespace: cellular_component
def:
  "A protein complex consisting of cyclin Kand cyclin-dependent kinase 12 (CDK12). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner." [PMID:22012619]


id: GO:0002945
name: cyclin K-CDK13 complex
namespace: cellular_component
def:
  "A protein complex consisting of cyclin Kand cyclin-dependent kinase 13 (CDK13). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner." [PMID:22012619]


id: GO:0002946
name: tRNA C5-cytosine methylation
namespace: biological_process
def:
  "The process whereby a cytosine in a tRNA is methylated at position 5 of the cytosine." [ISBN:1-55581-073-x]


id: GO:0002947
name: tumor necrosis factor receptor superfamily complex
namespace: cellular_component
def:
  "A receptor complex that contains one or more members of the tumor necrosis factor (TNF) receptor superfamily." [GOC:krc]


id: GO:0002948
name: archaeosine synthase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: L-glutamine + 7-cyano-7-carbaguanine15 in tRNA + H2O = L-glutamate + archaeine15 in tRNA." [PMID:20129918, Wikipedia:Archaeosine_synthase]


id: GO:0002949
name: tRNA threonylcarbamoyladenosine modification
namespace: biological_process
def:
  "The attachment of a carbonyl group and a threonine to the amino group of the adenine residue immediately 3' of the anticodon, in tRNAs that decode ANN codons (where N is any base)." [GO:0070526, GOC:imk, GOC:mah, PMID:19287007, PMID:21183954, PMID:23258706]


id: GO:0003001
name: obsolete generation of a signal involved in cell-cell signaling
namespace: biological_process
def:
  "The cellular process that creates a physical entity or change in state, i.e. a signal, that originates in one cell and is used to transfer information to another cell. This process begins with the initial formation of the signal and ends with the mature form and placement of the signal." [GOC:dph]


id: GO:0003002
name: regionalization
namespace: biological_process
def:
  "The pattern specification process that results in the subdivision of an axis or axes in space to define an area or volume in which specific patterns of cell differentiation will take place or in which cells interpret a specific environment." [GOC:dph, GOC:isa_complete]


id: GO:0003003
name: follicular fluid formation in ovarian follicle antrum involved in fused antrum stage
namespace: biological_process
def:
  "The ovulation cycle process in which one central cavity separating the oocyte/cumulus complex from mural granulosa and theca cells is formed as part of the fused antrum stage of oogenesis." [GOC:dph, GOC:isa_complete]


id: GO:0003004
name: follicular fluid formation in ovarian follicle antrum involved in distinct antral spaces stage
namespace: biological_process
def:
  "The menstrual cycle process in which one central cavity separating the oocyte/cumulus complex from mural granulosa and theca cells is formed as part of the antral spaces stage of oogenesis." [GOC:dph, GOC:isa_complete]


id: GO:0003005
name: follicular fluid formation in ovarian follicle antrum involved in scattered antral spaces stage
namespace: biological_process
def:
  "The menstrual cycle process in which one central cavity separating the oocyte/cumulus complex from mural granulosa and theca cells is formed as part of the scattered antral spaces stage of oogenesis." [GOC:dph, GOC:isa_complete]


id: GO:0003006
name: developmental process involved in reproduction
namespace: biological_process
def:
  "A developmental process in which a progressive change in the state of some part of an organism specifically contributes to its ability to form offspring." [GOC:dph, GOC:isa_complete]


id: GO:0003007
name: heart morphogenesis
namespace: biological_process
def:
  "The developmental process in which the heart is generated and organized. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood." [GOC:dph, GOC:isa_complete]


id: GO:0003008
name: system process
namespace: biological_process
def:
  "A multicellular organismal process carried out by any of the organs or tissues in an organ system. An organ system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a biological objective." [GOC:mtg_cardio]


id: GO:0003009
name: skeletal muscle contraction
namespace: biological_process
def:
  "A process in which force is generated within skeletal muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. In the skeletal muscle, the muscle contraction takes advantage of an ordered sarcomeric structure and in most cases it is under voluntary control." [GOC:mtg_cardio, GOC:mtg_muscle]


id: GO:0003010
name: voluntary skeletal muscle contraction
namespace: biological_process
def:
  "A process in which force is generated within voluntary skeletal muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. In the voluntary skeletal muscle, the muscle contraction takes advantage of an ordered sarcomeric structure and it is under voluntary control. Voluntary skeletal muscle is skeletal muscle that is under conscious control." [GOC:mtg_cardio, GOC:mtg_muscle]


id: GO:0003011
name: involuntary skeletal muscle contraction
namespace: biological_process
def:
  "A process in which force is generated within involuntary skeletal muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. Involuntary skeletal muscle is skeletal muscle that is not under conscious control." [GOC:mtg_cardio, GOC:mtg_muscle]


id: GO:0003012
name: muscle system process
namespace: biological_process
def:
  "A organ system process carried out at the level of a muscle. Muscle tissue is composed of contractile cells or fibers." [GOC:mtg_cardio]


id: GO:0003013
name: circulatory system process
namespace: biological_process
def:
  "A organ system process carried out by any of the organs or tissues of the circulatory system. The circulatory system is an organ system that moves extracellular fluids to and from tissue within a multicellular organism." [GOC:mtg_cardio]


id: GO:0003014
name: renal system process
namespace: biological_process
def:
  "A organ system process carried out by any of the organs or tissues of the renal system. The renal system maintains fluid balance, and contributes to electrolyte balance, acid/base balance, and disposal of nitrogenous waste products. In humans, the renal system comprises a pair of kidneys, a pair of ureters, urinary bladder, urethra, sphincter muscle and associated blood vessels; in other species, the renal system may comprise related structures (e.g., nephrocytes and malpighian tubules in Drosophila)." [GOC:cjm, GOC:mtg_cardio, GOC:mtg_kidney_jan10]


id: GO:0003015
name: heart process
namespace: biological_process
def:
  "A circulatory system process carried out by the heart. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood." [GOC:mtg_cardio]


id: GO:0003016
name: respiratory system process
namespace: biological_process
def:
  "A system process carried out by the organs and tissues of the respiratory system. The respiratory system is an organ system responsible for respiratory gaseous exchange." [GOC:dph, GOC:mtg_cardio, GOC:tb]


id: GO:0003019
name: central nervous system control of baroreceptor feedback
namespace: biological_process
def:
  "The neurological process in which nerve impulses arising in the aorta or the carotid sinuses travel to the medulla and reach the nucleus of tractus solaris." [GOC:mtg_cardio, ISBN:0323031951]


id: GO:0003020
name: detection of reduced oxygen by chemoreceptor signaling
namespace: biological_process
def:
  "The process in which information about the levels of oxygen are received and are converted to a molecular signal by chemoreceptors in the carotid bodies and the aortic bodies." [GOC:mtg_cardio, ISBN:0323031951]


id: GO:0003021
name: detection of increased carbon dioxide by chemoreceptor signaling
namespace: biological_process
def:
  "The process in which information about the levels of carbon dioxide are received and are converted to a molecular signal by chemoreceptors in the carotid bodies and the aortic bodies." [GOC:mtg_cardio, ISBN:0323031951]


id: GO:0003022
name: detection of pH by chemoreceptor signaling
namespace: biological_process
def:
  "The process in which information about the levels of hydrogen ions are received and are converted to a molecular signal by chemoreceptors." [GOC:mtg_cardio, ISBN:0323031951]


id: GO:0003023
name: baroreceptor detection of increased arterial stretch
namespace: biological_process
def:
  "The series of events by which an increase in diameter of an artery is detected and converted to a molecular signal." [GOC:mtg_cardio]


id: GO:0003024
name: baroreceptor detection of decreased arterial stretch
namespace: biological_process
def:
  "The series of events by which a decrease in diameter of an artery is detected and converted to a molecular signal." [GOC:mtg_cardio]


id: GO:0003025
name: regulation of systemic arterial blood pressure by baroreceptor feedback
namespace: biological_process
def:
  "The neural regulation of blood pressure in which baroreceptors sense the amount of stretch occurring in vessels and respond to the input via central nervous system control." [GOC:dph, GOC:mtg_cardio, GOC:tb]


id: GO:0003026
name: regulation of systemic arterial blood pressure by aortic arch baroreceptor feedback
namespace: biological_process
def:
  "The process that modulates blood pressure by sensing the amount of stretch occurring in the aorta and responding to the input via central nervous system control." [GOC:dph, GOC:mtg_cardio, GOC:tb]


id: GO:0003027
name: regulation of systemic arterial blood pressure by carotid body chemoreceptor signaling
namespace: biological_process
def:
  "The process that modulates blood pressure by the action of chemoreceptors found in the carotid bodies and their resultant modulation of the vasomotor center. Chemoreceptors respond to oxygen, carbon dioxide and hydrogen ions." [GOC:dph, GOC:mtg_cardio, GOC:tb]


id: GO:0003028
name: regulation of systemic arterial blood pressure by aortic body chemoreceptor signaling
namespace: biological_process
def:
  "The process that modulates blood pressure by the action of chemoreceptors found in the aortic bodies and their resultant modulation of the vasomotor center. Chemoreceptors respond to oxygen, carbon dioxide and hydrogen ions." [GOC:dph, GOC:mtg_cardio, GOC:tb]


id: GO:0003029
name: detection of hypoxic conditions in blood by carotid body chemoreceptor signaling
namespace: biological_process
def:
  "The process in which information about a lack of oxygen are received and are converted to a molecular signal by chemoreceptors in the carotid bodies." [GOC:mtg_cardio]


id: GO:0003030
name: detection of hydrogen ion
namespace: biological_process
def:
  "The series of events in which a hydrogen ion stimulus is received by a cell and converted into a molecular signal." [GOC:mtg_cardio]


id: GO:0003031
name: detection of carbon dioxide
namespace: biological_process
def:
  "The series of events in which a carbon dioxide stimulus is received by a cell and converted into a molecular signal." [GOC:mtg_cardio]


id: GO:0003032
name: detection of oxygen
namespace: biological_process
def:
  "The series of events in which an oxygen stimulus is received by a cell and converted into a molecular signal." [GOC:mtg_cardio]


id: GO:0003033
name: detection of hypoxic conditions in blood by aortic body chemoreceptor signaling
namespace: biological_process
def:
  "The process in which information about a lack of oxygen are received and are converted to a molecular signal by chemoreceptors in the aortic bodies." [GOC:mtg_cardio]


id: GO:0003034
name: detection of increased carbon dioxide by aortic body chemoreceptor signaling
namespace: biological_process
def:
  "The process in which information about the levels of carbon dioxide are received and are converted to a molecular signal by chemoreceptors in an aortic body." [GOC:mtg_cardio]


id: GO:0003035
name: detection of increased carbon dioxide by carotid body chemoreceptor signaling
namespace: biological_process
def:
  "The process in which information about the levels of carbon dioxide are received and are converted to a molecular signal by chemoreceptors in a carotid body." [GOC:mtg_cardio]


id: GO:0003036
name: detection of pH by aortic body chemoreceptor signaling
namespace: biological_process
def:
  "The process in which information about the levels of hydrogen ions are received and are converted to a molecular signal by chemoreceptors in an aortic body." [GOC:mtg_cardio]


id: GO:0003037
name: detection of pH by carotid body chemoreceptor signaling
namespace: biological_process
def:
  "The process in which information about the levels of hydrogen ions are received and are converted to a molecular signal by chemoreceptors in a carotid body." [GOC:mtg_cardio]


id: GO:0003038
name: detection of reduced oxygen by aortic body chemoreceptor signaling
namespace: biological_process
def:
  "The process in which information about the levels of oxygen are received and are converted to a molecular signal by chemoreceptors in an aortic body." [GOC:mtg_cardio]


id: GO:0003039
name: detection of reduced oxygen by carotid body chemoreceptor signaling
namespace: biological_process
def:
  "The process in which information about the levels of oxygen are received and are converted to a molecular signal by chemoreceptors in a carotid body." [GOC:mtg_cardio]


id: GO:0003040
name: excitation of vasomotor center by aortic body chemoreceptor signaling
namespace: biological_process
def:
  "The process in which the molecular signal from an aortic body is relayed to the vasomotor center, causing it to signal an increase arterial pressure." [GOC:mtg_cardio]


id: GO:0003041
name: excitation of vasomotor center by carotid body chemoreceptor signaling
namespace: biological_process
def:
  "The process in which the molecular signal from a carotid body is relayed to the vasomotor center, causing it to signal an increase arterial pressure." [GOC:mtg_cardio]


id: GO:0003042
namespace: biological_process
name:
  vasoconstriction of artery involved in carotid body chemoreceptor response to lowering of systemic arterial blood pressure

def:
  "A process that is triggered by carotid body-vasomotor excitation and results in a decrease in the diameter of an artery during the chemoreceptor response to decreased blood pressure." [ISBN:0323031951]


id: GO:0003043
namespace: biological_process
name:
  vasoconstriction of artery involved in aortic body chemoreceptor response to lowering of systemic arterial blood pressure

def:
  "A process that is triggered by aortic body-vasomotor excitation and results in a decrease in the diameter of an artery during the chemoreceptor response to decreased blood pressure." [GOC:mtg_cardio]


id: GO:0003044
name: regulation of systemic arterial blood pressure mediated by a chemical signal
namespace: biological_process
def:
  "The regulation of blood pressure mediated by biochemical signaling: hormonal, autocrine or paracrine." [GOC:mtg_cardio]


id: GO:0003045
name: regulation of systemic arterial blood pressure by physical factors
namespace: biological_process
def:
  "The regulation of blood pressure mediated by detection of forces within the circulatory system." [GOC:mtg_cardio]


id: GO:0003046
name: regulation of systemic arterial blood pressure by stress relaxation
namespace: biological_process
def:
  "The intrinsic circulatory process resulting from stress relaxation that modulates the force with which blood travels through the systemic arterial circulatory system. Stress relaxation is the adaptation of vessels to a new size as a result of changes in pressure in storage areas such as veins, the liver, the spleen, and the lungs." [GOC:mtg_cardio, ISBN:0721643949]


id: GO:0003047
name: regulation of systemic arterial blood pressure by epinephrine
namespace: biological_process
def:
  "The regulation of blood pressure mediated by the catecholamine signaling molecule epinephrine." [GOC:mtg_cardio]


id: GO:0003048
name: regulation of systemic arterial blood pressure by norepinephrine
namespace: biological_process
def:
  "The regulation of blood pressure mediated by the catecholamine signaling molecule norepinephrine." [GOC:mtg_cardio]


id: GO:0003049
name: regulation of systemic arterial blood pressure by capillary fluid shift
namespace: biological_process
def:
  "The intrinsic circulatory process resulting from capillary fluid shift that modulates the force with which blood travels through the systemic arterial circulatory system. Capillary fluid shift is the movement of fluid across the capillary membrane between the blood and the interstitial fluid compartment." [GOC:mtg_cardio, ISBN:0721643949]


id: GO:0003050
name: regulation of systemic arterial blood pressure by atrial natriuretic peptide
namespace: biological_process
def:
  "The regulation of blood pressure mediated by the signaling molecule atrial natriuretic peptide." [GOC:mtg_cardio]


id: GO:0003051
name: angiotensin-mediated drinking behavior
namespace: biological_process
def:
  "The drinking behavior that is mediated by the action of angiotensin in the brain. Angiotensin stimulates the brain centers that control thirst." [GOC:mtg_cardio]


id: GO:0003052
name: circadian regulation of systemic arterial blood pressure
namespace: biological_process
def:
  "Any process in which an organism modulates its blood pressure at different values with a regularity of approximately 24 hours." [GOC:mtg_cardio, GOC:rl]


id: GO:0003053
name: circadian regulation of heart rate
namespace: biological_process
def:
  "Any process in which an organism modulates its heart rate at different values with a regularity of approximately 24 hours." [GOC:mtg_cardio, GOC:rl]


id: GO:0003054
name: circadian regulation of systemic arterial blood pressure by the suprachiasmatic nucleus
namespace: biological_process
def:
  "The process in which the suprachiasmatic nucleus modulates blood pressure at different values with a regularity of approximately 24 hours." [GOC:mtg_cardio, GOC:rl]


id: GO:0003055
name: circadian regulation of heart rate by the suprachiasmatic nucleus
namespace: biological_process
def:
  "The process in which the suprachiasmatic nucleus modulates heart rate at different values with a regularity of approximately 24 hours." [GOC:mtg_cardio, GOC:rl]


id: GO:0003056
name: regulation of vascular smooth muscle contraction
namespace: biological_process
def:
  "Any process that increases the frequency, rate or extent of vascular smooth muscle contraction." [GOC:mtg_cardio, GOC:mtg_sensu, GOC:rl]


id: GO:0003057
name: regulation of the force of heart contraction by chemical signal
namespace: biological_process
def:
  "The regulation of the force of heart muscle contraction mediated by chemical signaling, hormonal, autocrine or paracrine." [GOC:mtg_cardio, GOC:rl]


id: GO:0003058
name: hormonal regulation of the force of heart contraction
namespace: biological_process
def:
  "The process in which the hormones modulates the force of heart muscle contraction. A hormone is one of a group of substances formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells, in the same organism, upon which they have a specific regulatory action." [GOC:mtg_cardio, GOC:rl]


id: GO:0003059
name: positive regulation of the force of heart contraction by epinephrine
namespace: biological_process
def:
  "The process in which the secretion of epinephrine into the bloodstream or released from nerve endings modulates the force of heart muscle contraction." [GOC:mtg_cardio, GOC:rl]


id: GO:0003060
name: negative regulation of the force of heart contraction by acetylcholine
namespace: biological_process
def:
  "The process in which acetylcholine released from vagus nerve endings binds to muscarinic receptors and decreases the force of heart muscle contraction." [GOC:mtg_cardio, GOC:rl]


id: GO:0003061
name: positive regulation of the force of heart contraction by norepinephrine
namespace: biological_process
def:
  "The process in which the secretion of norepinephrine into the bloodstream or released from nerve endings modulates the force of heart musclecontraction." [GOC:mtg_cardio, GOC:rl]


id: GO:0003062
name: regulation of heart rate by chemical signal
namespace: biological_process
def:
  "The regulation of the rate of heart contraction mediated by chemical signaling, hormonal, autocrine or paracrine." [GOC:dph, GOC:mtg_cardio, GOC:rl, GOC:tb]


id: GO:0003063
name: negative regulation of heart rate by acetylcholine
namespace: biological_process
def:
  "The process in which acetylcholine released from vagus nerve endings binds to muscarinic receptors on the pacemaker cells and decreases the rate of heart muscle contraction." [GOC:mtg_cardio, GOC:rl]


id: GO:0003064
name: regulation of heart rate by hormone
namespace: biological_process
def:
  "The process in which the hormones modulates the rate of heart muscle contraction. A hormone is one of a group of substances formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells, in the same organism, upon which they have a specific regulatory action." [GOC:mtg_cardio, GOC:rl]


id: GO:0003065
name: positive regulation of heart rate by epinephrine
namespace: biological_process
def:
  "The process in which the secretion of epinephrine into the bloodstream or released from nerve endings increases the rate of heart muscle contraction." [GOC:mtg_cardio, GOC:rl]


id: GO:0003066
name: positive regulation of heart rate by norepinephrine
namespace: biological_process
def:
  "The process in which the secretion of norepinephrine into the bloodstream or released from nerve endings increases the rate of heart muscle contraction." [GOC:mtg_cardio, GOC:rl]


id: GO:0003067
name: circadian regulation of systemic arterial blood pressure by hormone
namespace: biological_process
def:
  "The process in which hormones modulate the force with which blood passes through the circulatory system contributing to different values of blood pressure oscillating with a regularity of approximately 24 hours. A hormone is one of a group of substances formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells, in the same organism, upon which they have a specific regulatory action." [GOC:mtg_cardio]


id: GO:0003068
name: regulation of systemic arterial blood pressure by acetylcholine
namespace: biological_process
def:
  "The regulation of blood pressure mediated by acetylcholine signaling. Acetylcholine is an acetic acid ester of the organic base choline and functions as a neurotransmitter." [GOC:mtg_cardio, GOC:rl]


id: GO:0003069
name: vasodilation by acetylcholine involved in regulation of systemic arterial blood pressure
namespace: biological_process
def:
  "The process in which acetylcholine signaling causes vasodilation, resulting in a change in blood pressure." [GOC:mtg_cardio, GOC:rl]


id: GO:0003070
name: regulation of systemic arterial blood pressure by neurotransmitter
namespace: biological_process
def:
  "The regulation of blood pressure mediated by a neurotransmitter. A neurotransmitter is any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell." [GOC:mtg_cardio]


id: GO:0003071
name: renal system process involved in regulation of systemic arterial blood pressure
namespace: biological_process
def:
  "Renal process that modulates the force with which blood travels through the circulatory system. The process is controlled by a balance of processes that increase pressure and decrease pressure." [GOC:dph, GOC:mtg_cardio, GOC:tb]


id: GO:0003072
namespace: biological_process
name:
  renal control of peripheral vascular resistance involved in regulation of systemic arterial blood pressure

def:
  "The renal process that modulates the force with which blood travels through the circulatory system, by impeding blood flow through the peripheral vasculature." [GOC:mtg_cardio]


id: GO:0003073
name: regulation of systemic arterial blood pressure
namespace: biological_process
def:
  "The process that modulates the force with which blood travels through the systemic arterial circulatory system. The process is controlled by a balance of processes that increase pressure and decrease pressure." [GOC:mtg_cardio]


id: GO:0003074
name: obsolete regulation of diuresis
namespace: biological_process
def:
  "OBSOLETE. Any process that modulates the rate of diuresis. Diuresis is the process of renal water excretion." [GOC:mtg_cardio]


id: GO:0003075
namespace: biological_process
name:
  renal vasodilation of the peripheral vascular system involved in regulation of systemic arterial blood pressure

def:
  "The renal process that modulates the force with which blood travels through the circulatory system, by vasodilation of the peripheral vascular system." [GOC:mtg_cardio]


id: GO:0003077
name: obsolete negative regulation of diuresis
namespace: biological_process
def:
  "OBSOLETE. Any process that reduces the rate of diuresis. Diuresis is the process of renal water excretion." [GOC:mtg_cardio]


id: GO:0003078
name: obsolete regulation of natriuresis
namespace: biological_process
def:
  "OBSOLETE. Any process that modulates the frequency, rate, or extent of natriuresis, the process of renal sodium excretion." [GOC:mah]


id: GO:0003079
name: obsolete positive regulation of natriuresis
namespace: biological_process
def:
  "OBSOLETE. Any process that activates or increases the frequency, rate or extent of natriuresis." [GOC:mtg_cardio]


id: GO:0003080
name: obsolete negative regulation of natriuresis
namespace: biological_process
def:
  "OBSOLETE. Any process that stops, prevents, or decreases the frequency, rate, or extent of natriuresis, the process of renal sodium excretion." [GOC:mah]


id: GO:0003081
name: regulation of systemic arterial blood pressure by renin-angiotensin
namespace: biological_process
def:
  "The process in which renin-angiotensin modulates the force with which blood passes through the circulatory system." [GOC:mtg_cardio]


id: GO:0003082
name: obsolete positive regulation of renal output by angiotensin
namespace: biological_process
def:
  "OBSOLETE. Any process in which angiotensin directly increases the rate of natriuresis and diuresis in the kidney." [GOC:dph, GOC:mtg_cardio, GOC:tb]


id: GO:0003083
name: negative regulation of renal output by angiotensin
namespace: biological_process
def:
  "The process in which angiotensin directly decreases the rate of natriuresis and diuresis in the kidney." [GOC:dph, GOC:mtg_cardio, GOC:tb]


id: GO:0003084
name: positive regulation of systemic arterial blood pressure
namespace: biological_process
def:
  "The process that increases the force with which blood travels through the systemic arterial circulatory system." [GOC:mtg_cardio]


id: GO:0003085
name: negative regulation of systemic arterial blood pressure
namespace: biological_process
def:
  "The process that reduces the force with which blood travels through the systemic arterial circulatory system." [GOC:mtg_cardio]


id: GO:0003086
name: regulation of systemic arterial blood pressure by local renal renin-angiotensin
namespace: biological_process
def:
  "The process in which angiotensinogen metabolites in the kidney modulate the force with which blood passes through the renal circulatory system. The process begins when renin cleaves angiotensinogen." [GOC:mtg_cardio]


id: GO:0003087
name: positive regulation of the force of heart contraction by neuronal epinephrine
namespace: biological_process
def:
  "The process in which the release of epinephrine from nerve endings modulates the force of heart muscle contraction." [GOC:mtg_cardio]


id: GO:0003088
name: positive regulation of the force of heart contraction by circulating epinephrine
namespace: biological_process
def:
  "The process in which the secretion of epinephrine into the bloodstream modulates the force of heart muscle contraction." [GOC:mtg_cardio]


id: GO:0003089
name: positive regulation of the force of heart contraction by circulating epinephrine-norepinephrine
namespace: biological_process
def:
  "Any process that increases the force with which the cardiac muscles of the heart pump blood through the circulatory system as a result of the presence of epinephrine or norepinephrine in the bloodstream." [GOC:mtg_cardio]


id: GO:0003090
name: positive regulation of the force of heart contraction by neuronal epinephrine-norepinephrine
namespace: biological_process
def:
  "Any process that increases the force with which the cardiac muscles of the heart pump blood through the circulatory system as a result of the presence of epinephrine or norepinephrine released from the nerve endings." [GOC:mtg_cardio]


id: GO:0003091
name: renal water homeostasis
namespace: biological_process
def:
  "Renal process involved in the maintenance of an internal steady state of water in the body." [GOC:mtg_cardio]


id: GO:0003093
name: regulation of glomerular filtration
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of glomerular filtration. Glomerular filtration is the process in which blood is filtered by the glomerulus into the renal tubule." [GOC:mtg_cardio]


id: GO:0003094
name: glomerular filtration
namespace: biological_process
def:
  "The process in which plasma is filtered through the glomerular membrane which consists of capillary endothelial cells, the basement membrane, and epithelial cells. The glomerular filtrate is the same as plasma except it has no significant amount of protein." [GOC:mtg_cardio, GOC:sart, ISBN:0721643949]


id: GO:0003095
name: pressure natriuresis
namespace: biological_process
def:
  "The process in which the volume of blood increases renal pressure and thereby results in both an increase in urine volume (diuresis) and an increase in the amount of sodium excreted in the urine (natriuresis)." [GOC:mtg_cardio]


id: GO:0003098
name: tubuloglomerular feedback
namespace: biological_process
def:
  "The process in which blood volume is regulated due to a change in the rate of glomerular filtration. This is accomplished by a feedback mechanism that senses changes in the juxtaglomerular apparatus." [GOC:mtg_cardio]


id: GO:0003099
name: positive regulation of the force of heart contraction by chemical signal
namespace: biological_process
def:
  "Any process which increases the force of heart muscle contraction mediated by chemical signaling, hormonal, autocrine or paracrine." [GOC:mtg_cardio]


id: GO:0003100
name: regulation of systemic arterial blood pressure by endothelin
namespace: biological_process
def:
  "The process in which endothelin modulates the force with which blood passes through the circulatory system. Endothelin is a hormone that is released by the endothelium, and it is a vasoconstrictor." [GOC:mtg_cardio]


id: GO:0003101
name: regulation of systemic arterial blood pressure by circulatory epinephrine-norepinephrine
namespace: biological_process
def:
  "The process in which epinephrine-norepinephrine modulate the force with which blood passes through the circulatory system." [GOC:mtg_cardio]


id: GO:0003102
name: obsolete positive regulation of diuresis by angiotensin
namespace: biological_process
def:
  "OBSOLETE. Any process mediated by angiotensin that increases the rate of diuresis." [GOC:dph, GOC:mtg_cardio, GOC:tb]


id: GO:0003103
name: obsolete positive regulation of diuresis
namespace: biological_process
def:
  "OBSOLETE. Any process that activates or increases the frequency, rate or extent of diuresis. Diuresis is the process of renal water excretion." [GOC:mtg_cardio]


id: GO:0003104
name: positive regulation of glomerular filtration
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of glomerular filtration. Glomerular filtration is the processs whereby blood is filtered by the glomerulus into the renal tubule." [GOC:mtg_cardio]


id: GO:0003105
name: negative regulation of glomerular filtration
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of glomerular filtration. Glomerular filtration is the processs whereby blood is filtered by the glomerulus into the renal tubule." [GOC:mtg_cardio]


id: GO:0003106
name: negative regulation of glomerular filtration by angiotensin
namespace: biological_process
def:
  "The process in which angiotensin directly decreases the rate of glomerular filtration in the kidney. Glomerular filtration is the processs whereby blood is filtered by the glomerulus into the renal tubule." [GOC:dph, GOC:mah, GOC:tb]


id: GO:0003107
name: obsolete positive regulation of natriuresis by angiotensin
namespace: biological_process
def:
  "OBSOLETE. The process in which angiotensin increases the rate of natriuresis indirectly via diuresis. Natriuresis is the process of renal sodium excretion." [GOC:dph, GOC:mtg_cardio, GOC:tb]


id: GO:0003108
name: negative regulation of the force of heart contraction by chemical signal
namespace: biological_process
def:
  "Any process which decreases the force of heart muscle contraction mediated by chemical signaling, hormonal, autocrine or paracrine." [GOC:mtg_cardio]


id: GO:0003109
name: positive regulation of the force of heart contraction by circulating norepinephrine
namespace: biological_process
def:
  "The process in which the secretion of norepinephrine into the bloodstream modulates the force of heart muscle contraction." [GOC:mtg_cardio]


id: GO:0003110
name: positive regulation of the force of heart contraction by neuronal norepinephrine
namespace: biological_process
def:
  "The process in which the release of norepinephrine from nerve endings modulates the force of heart muscle contraction." [GOC:mtg_cardio]


id: GO:0003111
name: positive regulation of heart rate by circulating epinephrine
namespace: biological_process
def:
  "The process in which the secretion of epinephrine into the bloodstream increases the rate of heart muscle contraction." [GOC:mtg_cardio]


id: GO:0003112
name: positive regulation of heart rate by neuronal epinephrine
namespace: biological_process
def:
  "The process in which the secretion of epinephrine from nerve endings increases the rate of heart muscle contraction." [GOC:mtg_cardio]


id: GO:0003113
name: positive regulation of heart rate by neuronal norepinephrine
namespace: biological_process
def:
  "The process in which the secretion of norepinephrine released from nerve endings increases the rate of heart muscle contraction." [GOC:mtg_cardio]


id: GO:0003114
name: positive regulation of heart rate by circulating norepinephrine
namespace: biological_process
def:
  "The process in which the secretion of norepinephrine into the bloodstream increases the rate of heart muscle contraction." [GOC:mtg_cardio]


id: GO:0003115
name: regulation of vasoconstriction by epinephrine
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of reductions in the diameter of blood vessels as a result of secretion of epinephrine into the bloodstream or released by nerve endings." [GOC:mtg_cardio]


id: GO:0003116
name: regulation of vasoconstriction by norepinephrine
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of reductions in the diameter of blood vessels as a result of secretion of norepinephrine into the bloodstream or released by nerve endings." [GOC:mtg_cardio]


id: GO:0003117
name: regulation of vasoconstriction by circulating norepinephrine
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of reductions in the diameter of blood vessels as a result of secretion of norepinephrine into the bloodstream." [GOC:mtg_cardio]


id: GO:0003118
name: regulation of vasoconstriction by neuronal norepinephrine
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of reductions in the diameter of blood vessels as a result of norepinephrine released by nerve endings." [GOC:mtg_cardio]


id: GO:0003119
name: regulation of vasoconstriction by neuronal epinephrine
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of reductions in the diameter of blood vessels as a result of epinephrine released by nerve endings." [GOC:mtg_cardio]


id: GO:0003120
name: regulation of vasoconstriction by circulating epinephrine
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of reductions in the diameter of blood vessels as a result of secretion of epinephrine into the bloodstream." [GOC:mtg_cardio]


id: GO:0003121
name: regulation of vasodilation by epinephrine
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of increases in the diameter of blood vessels as a result of secretion of epinephrine into the bloodstream or released by nerve endings." [GOC:mtg_cardio]


id: GO:0003122
name: regulation of vasodilation by norepinephrine
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of increases in the diameter of blood vessels as a result of secretion of norepinephrine into the bloodstream or released by nerve endings." [GOC:mtg_cardio]


id: GO:0003123
name: regulation of vasodilation by circulating epinephrine
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of increases in the diameter of blood vessels as a result of secretion of epinephrine into the bloodstream." [GOC:mtg_cardio]


id: GO:0003124
name: regulation of vasodilation by neuronal epinephrine
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of increases in the diameter of blood vessels as a result of epinephrine released by nerve endings." [GOC:mtg_cardio]


id: GO:0003125
name: regulation of vasodilation by circulating norepinephrine
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of increases in the diameter of blood vessels as a result of secretion of norepinephrine into the bloodstream." [GOC:mtg_cardio]


id: GO:0003126
name: regulation of vasodilation by neuronal norepinephrine
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of increases in the diameter of blood vessels as a result of norepinephrine released by nerve endings." [GOC:mtg_cardio]


id: GO:0003127
name: detection of nodal flow
namespace: biological_process
def:
  "The series of events by which an endogenous stimulus is received by a cilium on a cell and converted to a molecular signal contributing to left/right asymmetry." [GOC:mtg_heart]


id: GO:0003128
name: heart field specification
namespace: biological_process
def:
  "The process that results in the delineation of a specific region of the lateral mesoderm into the area in which the heart will develop." [GOC:mtg_heart]


id: GO:0003129
name: heart induction
namespace: biological_process
def:
  "The close range interaction between mesoderm and endoderm or ectoderm that causes cells to change their fates and specify the development of the heart." [GOC:mtg_heart]


id: GO:0003130
name: BMP signaling pathway involved in heart induction
namespace: biological_process
def:
  "A series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, which contributes to heart induction." [GOC:mtg_heart]


id: GO:0003131
name: mesodermal-endodermal cell signaling
namespace: biological_process
def:
  "Any process that mediates the transfer of information from mesodermal cells to endodermal cells." [GOC:mtg_heart]


id: GO:0003132
name: mesodermal-endodermal cell signaling involved in heart induction
namespace: biological_process
def:
  "Any process that mediates the transfer of information from mesodermal cells to endodermal cells that contributes to heart induction." [GOC:mtg_heart]


id: GO:0003133
name: endodermal-mesodermal cell signaling
namespace: biological_process
def:
  "Any process that mediates the transfer of information from endodermal cells to mesodermal cells." [GOC:mtg_heart]


id: GO:0003134
name: endodermal-mesodermal cell signaling involved in heart induction
namespace: biological_process
def:
  "Any process that mediates the transfer of information from endodermal cells to mesodermal cells that contributes to heart induction." [GOC:mtg_heart]


id: GO:0003135
name: fibroblast growth factor receptor signaling pathway involved in heart induction
namespace: biological_process
def:
  "The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands that contributes to heart induction." [GOC:mtg_heart]


id: GO:0003136
name: negative regulation of heart induction by canonical Wnt signaling pathway
namespace: biological_process
def:
  "Any canonical Wnt signaling that decreases the rate, frequency or extent of heart induction." [GOC:mtg_heart, PMID:19862329]


id: GO:0003137
name: Notch signaling pathway involved in heart induction
namespace: biological_process
def:
  "The series of molecular signals initiated by binding of an extracellular ligand to a Notch receptor on the surface of the target cell that contributes to heart induction." [GOC:mtg_heart]


id: GO:0003138
name: primary heart field specification
namespace: biological_process
def:
  "The process that results in the delineation of a specific region of the lateral mesoderm into the area which will form the primary beating heart tube. In mammals the primary heart field gives rise to the left ventricle." [GOC:mtg_heart, GOC:rl]


id: GO:0003139
name: secondary heart field specification
namespace: biological_process
def:
  "The process that results in the delineation of a specific region of the lateral mesoderm into the area which will form the majority of the mesodermal component of the right ventricle, arterial pole (outflow tract) and venous pole (inflow tract)." [GOC:mtg_heart, GOC:rl, PMID:17276708]


id: GO:0003140
name: determination of left/right asymmetry in lateral mesoderm
namespace: biological_process
def:
  "The establishment of the lateral mesoderm with respect to the left and right halves." [GOC:mtg_heart]


id: GO:0003141
namespace: biological_process
name:
  obsolete transforming growth factor beta receptor signaling pathway involved in determination of lateral mesoderm left/right asymmetry

def:
  "OBSOLETE. The series of molecular signals generated as a consequence of a transforming growth factor beta receptor binding to one of its physiological ligands that contributes to lateral mesoderm left/right asymmetry determination." [GOC:mtg_heart]


id: GO:0003142
name: cardiogenic plate morphogenesis
namespace: biological_process
def:
  "The process in which the anatomical structures of the cardiogenic plate are generated and organized. The cardiogenic plate is the first recognizable structure derived from the heart field." [GOC:mtg_heart]


id: GO:0003143
name: embryonic heart tube morphogenesis
namespace: biological_process
def:
  "The process in which the anatomical structures of the embryonic heart tube are generated and organized. The embryonic heart tube is an epithelial tube that will give rise to the mature heart." [GOC:mtg_heart]


id: GO:0003144
name: embryonic heart tube formation
namespace: biological_process
def:
  "The process that gives rise to the embryonic heart tube. This process pertains to the initial formation of a structure from unspecified parts. The embryonic heart tube is an epithelial tube that will give rise to the mature heart." [GOC:mtg_heart]


id: GO:0003145
name: embryonic heart tube formation via epithelial folding
namespace: biological_process
def:
  "The process that gives rise to the embryonic heart tube by the cells of the heart field along a linear axis." [GOC:mtg_heart]


id: GO:0003146
name: heart jogging
namespace: biological_process
def:
  "The morphogenetic process in which the heart cone is displaced to the left with respect to the vector of the anterior-posterior axis." [GOC:mtg_heart, PMID:9334285]


id: GO:0003147
name: neural crest cell migration involved in heart formation
namespace: biological_process
def:
  "The characteristic movement of a cell from the dorsal ridge of the neural tube towards the heart and that contributes to heart formation." [GOC:mtg_heart]


id: GO:0003148
name: outflow tract septum morphogenesis
namespace: biological_process
def:
  "The process in which the anatomical structures of the outflow tract septum are generated and organized. The outflow tract septum is a partition in the outflow tract." [GOC:mtg_heart]


id: GO:0003149
name: membranous septum morphogenesis
namespace: biological_process
def:
  "The process in which the membranous septum is generated and organized. The membranous septum is the upper part of ventricular septum." [GOC:mtg_heart]


id: GO:0003150
name: muscular septum morphogenesis
namespace: biological_process
def:
  "The process in which the muscular septum is generated and organized. The muscular septum is the lower part of the ventricular septum." [GOC:mtg_heart]


id: GO:0003151
name: outflow tract morphogenesis
namespace: biological_process
def:
  "The process in which the anatomical structures of the outflow tract are generated and organized. The outflow tract is the portion of the heart through which blood flows into the arteries." [GOC:mtg_heart, UBERON:0004145]


id: GO:0003152
name: morphogenesis of an epithelial fold involved in embryonic heart tube formation
namespace: biological_process
def:
  "The morphogenetic process in which an epithelial sheet bends along a linear axis, contributing to embryonic heart tube formation." [GOC:mtg_heart]


id: GO:0003153
name: closure of embryonic heart tube
namespace: biological_process
def:
  "Creation of the central hole of the embryonic heart tube by sealing the edges of an epithelial fold." [GOC:mtg_heart]


id: GO:0003154
name: BMP signaling pathway involved in determination of left/right symmetry
namespace: biological_process
def:
  "A series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, which contributes to the determination of left/right symmetry." [GOC:mtg_heart, GOC:signaling]


id: GO:0003155
name: BMP signaling pathway involved in determination of lateral mesoderm left/right asymmetry
namespace: biological_process
def:
  "A series of molecular signals generated as a consequence of any member of the BMP (bone morphogenetic protein) family binding to a cell surface receptor that contributes to the determination of lateral mesoderm left/right asymmetry." [GOC:mtg_heart]


id: GO:0003156
name: regulation of organ formation
namespace: biological_process
def:
  "Any process that modulates the rate, frequency or extent of organ formation. Organ formation is the process pertaining to the initial formation of an organ from unspecified parts. The process begins with the specific processes that contribute to the appearance of the discrete structure, such as inductive events, and ends when the structural rudiment of the organ is recognizable, such as a condensation of mesenchymal cells into the organ rudiment." [GOC:dph, GOC:mtg_heart, GOC:tb]


id: GO:0003157
name: endocardium development
namespace: biological_process
def:
  "The process whose specific outcome is the progression of the endocardium over time, from its formation to the mature structure. The endocardium is an anatomical structure comprised of an endothelium and an extracellular matrix that forms the innermost layer of tissue of the heart, and lines the heart chambers." [GOC:mtg_heart]


id: GO:0003158
name: endothelium development
namespace: biological_process
def:
  "The process whose specific outcome is the progression of an endothelium over time, from its formation to the mature structure. Endothelium refers to the layer of cells lining blood vessels, lymphatics, the heart, and serous cavities, and is derived from bone marrow or mesoderm. Corneal endothelium is a special case, derived from neural crest cells." [GOC:mtg_heart]


id: GO:0003159
name: morphogenesis of an endothelium
namespace: biological_process
def:
  "The process in which the anatomical structure of an endothelium is generated and organized. Endothelium refers to the layer of cells lining blood vessels, lymphatics, the heart, and serous cavities, and is derived from bone marrow or mesoderm. Corneal endothelium is a special case, derived from neural crest cells." [GOC:mtg_heart]


id: GO:0003160
name: endocardium morphogenesis
namespace: biological_process
def:
  "The process in which the anatomical structure of the endocardium is generated and organized. The endocardium is an anatomical structure comprised of an endothelium and an extracellular matrix that forms the innermost layer of tissue of the heart, and lines the heart chambers." [GOC:mtg_heart]


id: GO:0003161
name: cardiac conduction system development
namespace: biological_process
def:
  "The process whose specific outcome is the progression of the cardiac conduction system over time, from its formation to the mature structure. The cardiac conduction system consists of specialized cardiomyocytes that regulate the frequency of heart beat." [GOC:mtg_heart]


id: GO:0003162
name: atrioventricular node development
namespace: biological_process
def:
  "The process whose specific outcome is the progression of the atrioventricular (AV) node over time, from its formation to the mature structure. The AV node is part of the cardiac conduction system that controls the timing of ventricle contraction by receiving electrical signals from the sinoatrial (SA) node and relaying them to the His-Purkinje system." [GOC:mtg_heart]


id: GO:0003163
name: sinoatrial node development
namespace: biological_process
def:
  "The process whose specific outcome is the progression of the sinoatrial (SA) node over time, from its formation to the mature structure. The SA node is part of the cardiac conduction system that controls the timing of heart muscle contraction. It relays electrical signals to the AV node." [GOC:mtg_heart]


id: GO:0003164
name: His-Purkinje system development
namespace: biological_process
def:
  "The process whose specific outcome is the progression of the His-Purkinje system over time, from its formation to the mature structure. The His-Purkinje system receives signals from the AV node and is composed of the fibers that regulate cardiac muscle contraction in the ventricles." [GOC:mtg_heart]


id: GO:0003165
name: Purkinje myocyte development
namespace: biological_process
def:
  "The process whose specific outcome is the progression of a Purkinje myocyte over time, from its formation to the mature structure. The Purkinje myocyte (also known as cardiac Purkinje fiber) is part of the cardiac conduction system that receives signals from the bundle of His and innervates the ventricular cardiac muscle." [GOC:mtg_cardiac_conduct_nov11, GOC:mtg_heart]


id: GO:0003166
name: bundle of His development
namespace: biological_process
def:
  "The process whose specific outcome is the progression of the bundle of His over time, from its formation to the mature structure. The bundle of His is part of the His-Purkinje system that transmits signals from the AV node to the cardiac Purkinje fibers." [GOC:mtg_heart]


id: GO:0003167
name: atrioventricular bundle cell differentiation
namespace: biological_process
def:
  "The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a cell of the atrioventricular bundle. These cells are specialized cardiomyocytes that transmit signals from the AV node to the cardiac Purkinje fibers." [GOC:mtg_heart]


id: GO:0003168
name: Purkinje myocyte differentiation
namespace: biological_process
def:
  "The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a Purkinje myocyte (also known as cardiac Purkinje fiber cell). These cells are specialized cardiomyocytes that receive signals from the bundle of His and innervate the ventricular cardiac muscle." [GOC:mtg_cardiac_conduct_nov11, GOC:mtg_heart]


id: GO:0003169
name: coronary vein morphogenesis
namespace: biological_process
def:
  "The process in which the anatomical structures of veins of the heart are generated and organized." [GOC:mtg_heart]


id: GO:0003170
name: heart valve development
namespace: biological_process
def:
  "The progression of a heart valve over time, from its formation to the mature structure. A heart valve is a structure that restricts the flow of blood to different regions of the heart and forms from an endocardial cushion." [GOC:mtg_heart]


id: GO:0003171
name: atrioventricular valve development
namespace: biological_process
def:
  "The progression of the atrioventricular valve over time, from its formation to the mature structure." [GOC:mtg_heart]


id: GO:0003172
name: sinoatrial valve development
namespace: biological_process
def:
  "The progression of the sinoatrial valve over time, from its formation to the mature structure." [GOC:mtg_heart]


id: GO:0003173
name: ventriculo bulbo valve development
namespace: biological_process
def:
  "The progression of the ventriculo bulbo valve over time, from its formation to the mature structure." [GOC:mtg_heart]


id: GO:0003174
name: mitral valve development
namespace: biological_process
def:
  "The progression of the mitral valve over time, from its formation to the mature structure." [GOC:mtg_heart]


id: GO:0003175
name: tricuspid valve development
namespace: biological_process
def:
  "The progression of the tricuspid valve over time, from its formation to the mature structure." [GOC:mtg_heart]


id: GO:0003176
name: aortic valve development
namespace: biological_process
def:
  "The progression of the aortic valve over time, from its formation to the mature structure." [GOC:mtg_heart]


id: GO:0003177
name: pulmonary valve development
namespace: biological_process
def:
  "The progression of the pulmonary valve over time, from its formation to the mature structure." [GOC:mtg_heart]


id: GO:0003178
name: coronary sinus valve development
namespace: biological_process
def:
  "The progression of the valve of the coronary sinus over time, from its formation to the mature structure." [GOC:mtg_heart]


id: GO:0003180
name: aortic valve morphogenesis
namespace: biological_process
def:
  "The process in which the structure of the aortic valve is generated and organized." [GOC:mtg_heart]


id: GO:0003181
name: atrioventricular valve morphogenesis
namespace: biological_process
def:
  "The process in which the structure of the atrioventricular valve is generated and organized." [GOC:mtg_heart]


id: GO:0003182
name: coronary sinus valve morphogenesis
namespace: biological_process
def:
  "The process in which the structure of the coronary sinus valve is generated and organized." [GOC:mtg_heart]


id: GO:0003183
name: mitral valve morphogenesis
namespace: biological_process
def:
  "The process in which the structure of the mitral valve is generated and organized." [GOC:mtg_heart]


id: GO:0003184
name: pulmonary valve morphogenesis
namespace: biological_process
def:
  "The process in which the structure of the pulmonary valve is generated and organized." [GOC:mtg_heart]


id: GO:0003185
name: sinoatrial valve morphogenesis
namespace: biological_process
def:
  "The process in which the structure of the sinoatrial valve is generated and organized." [GOC:mtg_heart]


id: GO:0003186
name: tricuspid valve morphogenesis
namespace: biological_process
def:
  "The process in which the structure of the tricuspid valve is generated and organized." [GOC:mtg_heart]


id: GO:0003187
name: ventriculo bulbo valve morphogenesis
namespace: biological_process
def:
  "The process in which the structure of the ventriculo bulbo valve is generated and organized." [GOC:mtg_heart]


id: GO:0003188
name: heart valve formation
namespace: biological_process
def:
  "The developmental process pertaining to the initial formation of a heart valve from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable." [GOC:mtg_heart]


id: GO:0003189
name: aortic valve formation
namespace: biological_process
def:
  "The developmental process pertaining to the initial formation of the aortic valve from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable." [GOC:mtg_heart]


id: GO:0003190
name: atrioventricular valve formation
namespace: biological_process
def:
  "The developmental process pertaining to the initial formation of the atrioventricular valve from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable." [GOC:mtg_heart]


id: GO:0003191
name: coronary sinus valve formation
namespace: biological_process
def:
  "The developmental process pertaining to the initial formation of the coronary sinus valve from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable." [GOC:mtg_heart]


id: GO:0003192
name: mitral valve formation
namespace: biological_process
def:
  "The developmental process pertaining to the initial formation of the mitral valve from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable." [GOC:mtg_heart]


id: GO:0003193
name: pulmonary valve formation
namespace: biological_process
def:
  "The developmental process pertaining to the initial formation of the pulmonary valve from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable." [GOC:mtg_heart]


id: GO:0003194
name: sinoatrial valve formation
namespace: biological_process
def:
  "The developmental process pertaining to the initial formation of the sinoatrial valve from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable." [GOC:mtg_heart]


id: GO:0003195
name: tricuspid valve formation
namespace: biological_process
def:
  "The developmental process pertaining to the initial formation of the tricuspid valve from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable." [GOC:mtg_heart]


id: GO:0003196
name: ventriculo bulbo valve formation
namespace: biological_process
def:
  "The developmental process pertaining to the initial formation of the ventriculo bulbo valve from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable." [GOC:mtg_heart]


id: GO:0003197
name: endocardial cushion development
namespace: biological_process
def:
  "The progression of a cardiac cushion over time, from its initial formation to the mature structure. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves." [GOC:mtg_heart]


id: GO:0003198
name: epithelial to mesenchymal transition involved in endocardial cushion formation
namespace: biological_process
def:
  "A transition where a cardiac epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell that will contribute to the formation of the endocardial cushion." [GOC:mtg_heart]


id: GO:0003199
name: endocardial cushion to mesenchymal transition involved in heart valve formation
namespace: biological_process
def:
  "A transition where an endocardial cushion cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell that will contribute to the formation of a cardiac valve." [GOC:mtg_heart]


id: GO:0003200
name: endocardial cushion to mesenchymal transition involved in heart chamber septation
namespace: biological_process
def:
  "A transition where an endocardial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell that will contribute to the formation of the heart septum." [GOC:mtg_heart]


id: GO:0003201
name: epithelial to mesenchymal transition involved in coronary vasculature morphogenesis
namespace: biological_process
def:
  "A transition where a cardiac epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell that will contribute to the shaping of the coronary vasculature." [GOC:mtg_heart]


id: GO:0003202
name: endocardial cushion to mesenchymal transition involved in cardiac skeleton development
namespace: biological_process
def:
  "A transition where an endocardial cushion cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell that will give rise to the cardiac skeleton." [GOC:mtg_heart]


id: GO:0003203
name: endocardial cushion morphogenesis
namespace: biological_process
def:
  "The process in which the anatomical structure of the endocardial cushion is generated and organized. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves." [GOC:mtg_heart]


id: GO:0003204
name: cardiac skeleton development
namespace: biological_process
def:
  "The progression of the cardiac skeleton over time, from its formation to the mature structure. The cardiac skeleton is a specialized extracellular matrix that separates the atria from the ventricles and provides physical support for the heart." [GOC:mtg_heart]


id: GO:0003205
name: cardiac chamber development
namespace: biological_process
def:
  "The progression of a cardiac chamber over time, from its formation to the mature structure. A cardiac chamber is an enclosed cavity within the heart." [GOC:mtg_heart]


id: GO:0003206
name: cardiac chamber morphogenesis
namespace: biological_process
def:
  "The process in which a cardiac chamber is generated and organized. A cardiac chamber is an enclosed cavity within the heart." [GOC:mtg_heart]


id: GO:0003207
name: cardiac chamber formation
namespace: biological_process
def:
  "The developmental process pertaining to the initial formation of a cardiac chamber from unspecified parts. A cardiac chamber is an enclosed cavity within the heart." [GOC:mtg_heart]


id: GO:0003208
name: cardiac ventricle morphogenesis
namespace: biological_process
def:
  "The process in which the cardiac ventricle is generated and organized. A cardiac ventricle receives blood from a cardiac atrium and pumps it out of the heart." [GOC:mtg_heart]


id: GO:0003209
name: cardiac atrium morphogenesis
namespace: biological_process
def:
  "The process in which the cardiac atrium is generated and organized. A cardiac atrium receives blood from a vein and pumps it to a cardiac ventricle." [GOC:mtg_heart]


id: GO:0003210
name: cardiac atrium formation
namespace: biological_process
def:
  "The developmental process pertaining to the initial formation of a cardiac atrium from unspecified parts. A cardiac atrium receives blood from a vein and pumps it to a cardiac ventricle." [GOC:mtg_heart]


id: GO:0003211
name: cardiac ventricle formation
namespace: biological_process
def:
  "The developmental process pertaining to the initial formation of a cardiac ventricle from unspecified parts. A cardiac ventricle receives blood from a cardiac atrium and pumps it out of the heart." [GOC:mtg_heart]


id: GO:0003216
name: cardiac left atrium formation
namespace: biological_process
def:
  "The developmental process pertaining to the initial formation of a left cardiac atrium from unspecified parts." [GOC:mtg_heart]


id: GO:0003217
name: cardiac right atrium formation
namespace: biological_process
def:
  "The developmental process pertaining to the initial formation of a cardiac right atrium from unspecified parts." [GOC:mtg_heart]


id: GO:0003218
name: cardiac left ventricle formation
namespace: biological_process
def:
  "The developmental process pertaining to the initial formation of a left cardiac ventricle from unspecified parts." [GOC:mtg_heart]


id: GO:0003219
name: cardiac right ventricle formation
namespace: biological_process
def:
  "The developmental process pertaining to the initial formation of a right cardiac ventricle from unspecified parts." [GOC:mtg_heart]


id: GO:0003220
name: left ventricular cardiac muscle tissue morphogenesis
namespace: biological_process
def:
  "The process in which the anatomical structures of left cardiac ventricle muscle are generated and organized." [GOC:mtg_heart]


id: GO:0003221
name: right ventricular cardiac muscle tissue morphogenesis
namespace: biological_process
def:
  "The process in which the anatomical structures of the right cardiac ventricle muscle are generated and organized." [GOC:mtg_heart]


id: GO:0003222
name: ventricular trabecula myocardium morphogenesis
namespace: biological_process
def:
  "The process in which the anatomical structures of the trabecular cardiac ventricle muscle are generated and organized." [GOC:mtg_heart]


id: GO:0003223
name: ventricular compact myocardium morphogenesis
namespace: biological_process
def:
  "The process in which the anatomical structures of the compact cardiac ventricle muscle are generated and organized." [GOC:mtg_heart]


id: GO:0003224
name: left ventricular compact myocardium morphogenesis
namespace: biological_process
def:
  "The process in which the anatomical structures of cardiac left ventricular compact myocardium are generated and organized." [GOC:mtg_heart]


id: GO:0003225
name: left ventricular trabecular myocardium morphogenesis
namespace: biological_process
def:
  "The process in which the anatomical structures of cardiac left ventricular trabecular myocardium are generated and organized." [GOC:mtg_heart]


id: GO:0003226
name: right ventricular compact myocardium morphogenesis
namespace: biological_process
def:
  "The process in which the anatomical structures of the right ventricular compact myocardium are generated and organized." [GOC:mtg_heart]


id: GO:0003227
name: right ventricular trabecular myocardium morphogenesis
namespace: biological_process
def:
  "The process in which the anatomical structures of the right ventricular myocardium are generated and organized." [GOC:mtg_heart]


id: GO:0003228
name: atrial cardiac muscle tissue development
namespace: biological_process
def:
  "The process whose specific outcome is the progression of cardiac muscle of the atrium over time, from its formation to the mature structure." [GOC:mtg_heart]


id: GO:0003229
name: ventricular cardiac muscle tissue development
namespace: biological_process
def:
  "The process whose specific outcome is the progression of ventricular cardiac muscle over time, from its formation to the mature structure." [GOC:mtg_heart]


id: GO:0003230
name: cardiac atrium development
namespace: biological_process
def:
  "The process whose specific outcome is the progression of a cardiac atrium over time, from its formation to the mature structure. A cardiac atrium receives blood from a vein and pumps it to a cardiac ventricle." [GOC:mtg_heart]


id: GO:0003231
name: cardiac ventricle development
namespace: biological_process
def:
  "The process whose specific outcome is the progression of a cardiac ventricle over time, from its formation to the mature structure. A cardiac ventricle receives blood from a cardiac atrium and pumps it out of the heart." [GOC:mtg_heart]


id: GO:0003232
name: bulbus arteriosus development
namespace: biological_process
def:
  "The process whose specific outcome is the progression of the bulbus arteriosus over time, from its formation to the mature structure. The bulbus arteriosus is an elastic heart chamber." [GOC:mtg_heart]


id: GO:0003233
name: bulbus arteriosus morphogenesis
namespace: biological_process
def:
  "The process in which the bulbus arteriosus is generated and organized. The bulbus arteriosus is an elastic cardiac chamber." [GOC:mtg_heart]


id: GO:0003234
name: bulbus arteriosus formation
namespace: biological_process
def:
  "The developmental process pertaining to the initial formation of the bulbus arteriosus from unspecified parts. The bulbus arteriosus is an elastic chamber of the heart." [GOC:mtg_heart]


id: GO:0003235
name: sinus venosus development
namespace: biological_process
def:
  "The progression of the sinus venosus over time, from its formation to the mature structure. The sinus venosus is a heart chamber attached to the atrium on the venous side of the embryonic heart." [GOC:mtg_heart]


id: GO:0003236
name: sinus venosus morphogenesis
namespace: biological_process
def:
  "The process in which the sinus venosus is generated and organized. The sinus venosus is a heart chamber attached to the atrium on the venous side of the embryonic heart." [GOC:mtg_heart]


id: GO:0003237
name: sinus venosus formation
namespace: biological_process
def:
  "The developmental process pertaining to the initial formation of the sinus venosus from unspecified parts. The sinus venosus is a heart chamber attached to the atrium on the venous side of the embryonic heart." [GOC:mtg_heart]


id: GO:0003238
name: conus arteriosus development
namespace: biological_process
def:
  "The progression of the conus arteriosus over time, from its formation to the mature structure. The conus arteriosus is a valved chamber with thick muscular walls stemming from the ventricle and connecting to the pulmonary trunk." [GOC:mtg_heart]


id: GO:0003239
name: conus arteriosus morphogenesis
namespace: biological_process
def:
  "The process in which the conus arteriosus is generated and organized. The conus arteriosus is a valved chamber with thick muscular walls stemming from the ventricle and connecting to the pulmonary trunk." [GOC:mtg_heart]


id: GO:0003240
name: conus arteriosus formation
namespace: biological_process
def:
  "The developmental process pertaining to the initial formation of the conus arteriosus from unspecified parts. The conus arteriosus is a valved chamber with thick muscular walls stemming from the ventricle and connecting to the pulmonary trunk." [GOC:mtg_heart]


id: GO:0003242
name: cardiac chamber ballooning
namespace: biological_process
def:
  "The morphogenic growth in which the chambers of the heart expand in size, contributing to their shaping." [GOC:mtg_heart]


id: GO:0003243
name: circumferential growth involved in left ventricle morphogenesis
namespace: biological_process
def:
  "The morphogenetic growth in which the left ventricle grows expanding its external boundary." [GOC:mtg_heart, PMID:14709543]


id: GO:0003245
name: cardiac muscle tissue growth involved in heart morphogenesis
namespace: biological_process
def:
  "The developmental growth of cardiac muscle tissue that contributes to the shaping of the heart." [GOC:mtg_heart]


id: GO:0003246
name: embryonic cardiac muscle cell growth involved in heart morphogenesis
namespace: biological_process
def:
  "The growth of a cardiac muscle cell during the embryonic period, that contributes to the shaping of the heart." [GOC:mtg_heart]


id: GO:0003247
name: post-embryonic cardiac muscle cell growth involved in heart morphogenesis
namespace: biological_process
def:
  "The growth of a cardiac muscle cell during the postembryonic period that contributes to the shaping of the heart." [GOC:mtg_heart]


id: GO:0003248
name: heart capillary growth
namespace: biological_process
def:
  "The increase in heart capillaries that accompanies physiological hypertrophy of cardiac muscle." [GOC:mtg_heart]


id: GO:0003249
name: cell proliferation involved in heart valve morphogenesis
namespace: biological_process
def:
  "The multiplication or reproduction of cells that contributes to the shaping of a heart valve." [GOC:mtg_heart]


id: GO:0003250
name: regulation of cell proliferation involved in heart valve morphogenesis
namespace: biological_process
def:
  "Any process that modulates the rate, frequency or extent of cell proliferation that contributes to the shaping of a heart valve." [GOC:mtg_heart]


id: GO:0003251
name: positive regulation of cell proliferation involved in heart valve morphogenesis
namespace: biological_process
def:
  "Any process that increases the rate, frequency or extent of cell proliferation that contributes to the shaping of a heart valve." [GOC:mtg_heart]


id: GO:0003252
name: negative regulation of cell proliferation involved in heart valve morphogenesis
namespace: biological_process
def:
  "Any process that decreases the rate, frequency or extent of cell proliferation that contributes to the shaping of a heart valve." [GOC:mtg_heart]


id: GO:0003253
name: cardiac neural crest cell migration involved in outflow tract morphogenesis
namespace: biological_process
def:
  "The orderly movement of a neural crest cell from one site to another that will contribute to the morphogenesis of the outflow tract." [GOC:mtg_heart]


id: GO:0003254
name: regulation of membrane depolarization
namespace: biological_process
def:
  "Any process that modulates the rate, frequency or extent of membrane depolarization. Membrane depolarization is the process in which membrane potential changes in the depolarizing direction from the resting potential, usually from negative to positive." [GOC:dph, GOC:tb]


id: GO:0003255
name: endocardial precursor cell differentiation
namespace: biological_process
def:
  "The process in which a relatively unspecialized mesodermal cell acquires the specialized structural and/or functional features of an endocardial precursor cell. A endocardial precursor cell is a cell that has been committed to a endocardial cell fate, but will undergo further cell divisions rather than terminally differentiate." [GOC:mtg_heart]


id: GO:0003256
namespace: biological_process
name:
  regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation

def:
  "Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter that contributes to the differentiation of a myocardial precursor cell." [GOC:mtg_heart]


id: GO:0003257
namespace: biological_process
name:
  positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation

def:
  "Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter that contributes to the differentiation of a myocardial precursor cell." [GOC:mtg_heart]


id: GO:0003258
namespace: biological_process
name:
  regulation of transcription from RNA polymerase II promoter involved in endocardial precursor cell differentiation

def:
  "Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter that contributes to the differentiation of an endocardial precursor cell." [GOC:mtg_heart]


id: GO:0003259
name: cardioblast anterior-lateral migration
namespace: biological_process
def:
  "The orderly movement of a cardioblast toward the head and laterally to form the heart field. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating." [GOC:mtg_heart]


id: GO:0003260
name: cardioblast migration
namespace: biological_process
def:
  "The orderly movement of a cardiac progenitor cell to form the heart field. Cardiac progenitor cells are non-terminally differentiated, mesoderm-derived cells that are committed to differentiate into cells of the heart. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating." [GOC:mtg_heart]


id: GO:0003261
name: cardiac muscle progenitor cell migration to the midline involved in heart field formation
namespace: biological_process
def:
  "The orderly movement of a myocardial progenitor cell toward the midline to form the heart field. Cardiac muscle progenitor cells are non-terminally differentiated, mesoderm-derived cells that are committed to differentiate into myocardial cells of the heart." [GOC:mtg_heart]


id: GO:0003262
name: endocardial progenitor cell migration to the midline involved in heart field formation
namespace: biological_process
def:
  "The orderly movement of an endocardial progenitor cell toward the midline to form the heart field. Cardiac muscle progenitor cells are non-terminally differentiated, mesoderm-derived cells that are committed to differentiate into endocardial cells of the heart." [GOC:mtg_heart]


id: GO:0003263
name: cardioblast proliferation
namespace: biological_process
def:
  "The multiplication or reproduction of cardioblasts, resulting in the expansion of the population in the heart field. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating." [GOC:mtg_heart]


id: GO:0003264
name: regulation of cardioblast proliferation
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of cardioblast proliferation. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating." [GOC:mtg_heart]


id: GO:0003265
name: regulation of primary heart field cardioblast proliferation
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of cardioblast proliferation in the primary heart field. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating. In mammals the primary heart field gives rise to the left ventricle." [GOC:mtg_heart, GOC:rl]


id: GO:0003266
name: regulation of secondary heart field cardioblast proliferation
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of cardioblast proliferation in the second heart field. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating. The secondary heart field is the region of the heart that will form the majority of the mesodermal component of the right ventricle, the arterial pole (outflow tract) and the venous pole (inflow tract)." [GOC:mtg_heart, GOC:rl, PMID:17276708]


id: GO:0003267
namespace: biological_process
name:
  canonical Wnt signaling pathway involved in positive regulation of secondary heart field cardioblast proliferation

def:
  "A canonical Wnt signaling pathway that contributes to an increase in the frequency, or rate of cardioblast proliferation in the secondary heart field. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating." [GOC:mtg_heart]


id: GO:0003268
namespace: biological_process
name:
  fibroblast growth factor receptor signaling pathway involved in regulation of secondary heart field cardioblast proliferation

def:
  "The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands contributing to the modulation of the frequency, rate or extent of cardioblast proliferation in the secondary heart field. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating." [GOC:mtg_heart]


id: GO:0003269
name: BMP signaling pathway involved in regulation of secondary heart field cardioblast proliferation
namespace: biological_process
def:
  "A series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, which contributes to the modulation of the frequency, rate or extent of cardioblast proliferation in the secondary heart field. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating." [GOC:mtg_heart]


id: GO:0003270
name: Notch signaling pathway involved in regulation of secondary heart field cardioblast proliferation
namespace: biological_process
def:
  "The series of molecular signals initiated by binding of an extracellular ligand to a Notch receptor on the surface of the target cell contributing to the modulation of the frequency, rate or extent of cardioblast proliferation in the secondary heart field. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating." [GOC:mtg_heart]


id: GO:0003271
namespace: biological_process
name:
  smoothened signaling pathway involved in regulation of secondary heart field cardioblast proliferation

def:
  "The series of molecular signals generated as a consequence of activation of the transmembrane protein Smoothened contributing to the modulation of the frequency, rate or extent of cardioblast proliferation in the secondary heart field. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating." [GOC:mtg_heart]


id: GO:0003272
name: endocardial cushion formation
namespace: biological_process
def:
  "The developmental process pertaining to the initial formation of an endocardial cushion. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves." [GOC:mtg_heart, PMID:15797462]


id: GO:0003273
name: cell migration involved in endocardial cushion formation
namespace: biological_process
def:
  "The orderly movement of a cell from one site to another that will contribute to the formation of an endocardial cushion. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves." [GOC:mtg_heart]


id: GO:0003274
name: endocardial cushion fusion
namespace: biological_process
def:
  "The cell-cell adhesion process of mesenchymal cardiac cushion cells that contributes to the process of cushion shaping." [GOC:mtg_heart]


id: GO:0003275
name: apoptotic process involved in outflow tract morphogenesis
namespace: biological_process
def:
  "Any apoptotic process that contributes to the shaping of the outflow tract. The outflow tract is the portion of the heart through which blood flows into the arteries." [GOC:mtg_apoptosis, GOC:mtg_heart]


id: GO:0003276
name: apoptotic process involved in heart valve morphogenesis
namespace: biological_process
def:
  "Any apoptotic process that contributes to the shaping of a heart valve." [GOC:mtg_apoptosis, GOC:mtg_heart]


id: GO:0003277
name: apoptotic process involved in endocardial cushion morphogenesis
namespace: biological_process
def:
  "Any apoptotic process that contributes to the shaping of an endocardial cushion. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves." [GOC:mtg_apoptosis, GOC:mtg_heart]


id: GO:0003278
name: apoptotic process involved in heart morphogenesis
namespace: biological_process
def:
  "Any apoptotic process that contributes to the shaping of the heart." [GOC:mtg_apoptosis, GOC:mtg_heart]


id: GO:0003279
name: cardiac septum development
namespace: biological_process
def:
  "The progression of a cardiac septum over time, from its initial formation to the mature structure." [GOC:mtg_heart]


id: GO:0003281
name: ventricular septum development
namespace: biological_process
def:
  "The progression of the ventricular septum over time from its formation to the mature structure." [GOC:mtg_heart]


id: GO:0003282
name: ventricular septum intermedium development
namespace: biological_process
def:
  "The progression of the ventricular septum intermedium over time, from its formation to the mature structure." [GOC:mtg_heart]


id: GO:0003283
name: atrial septum development
namespace: biological_process
def:
  "The progression of the atrial septum over time, from its initial formation to the mature structure." [GOC:mtg_heart]


id: GO:0003284
name: septum primum development
namespace: biological_process
def:
  "The progression of the septum primum over time, from its formation to the mature structure." [GOC:mtg_heart]


id: GO:0003285
name: septum secundum development
namespace: biological_process
def:
  "The progression of the septum secundum over time, from its initial formation to the mature structure." [GOC:mtg_heart]


id: GO:0003286
name: atrial septum intermedium development
namespace: biological_process
def:
  "The progression of the atrial septum intermedium over time, from its formation to the mature structure." [GOC:mtg_heart]


id: GO:0003288
name: ventricular septum intermedium morphogenesis
namespace: biological_process
def:
  "The developmental process in which a ventricular septum intermedium is generated and organized." [GOC:mtg_heart]


id: GO:0003289
name: atrial septum primum morphogenesis
namespace: biological_process
def:
  "The process in which anatomical structure of an atrial septum primum is generated and organized." [GOC:mtg_heart]


id: GO:0003290
name: atrial septum secundum morphogenesis
namespace: biological_process
def:
  "The process in which anatomical structure of an atrial septum secundum is generated and organized." [GOC:mtg_heart]


id: GO:0003291
name: atrial septum intermedium morphogenesis
namespace: biological_process
def:
  "The process in which anatomical structure of an atrial septum intermedium is generated and organized." [GOC:mtg_heart]


id: GO:0003292
name: cardiac septum cell differentiation
namespace: biological_process
def:
  "The process in which an endocardial cushion cell becomes a cell of a cardiac septum." [GOC:mtg_heart]


id: GO:0003293
name: heart valve cell differentiation
namespace: biological_process
def:
  "The process in which an endocardial cushion cell give rise to a cell that is part of a heart valve." [GOC:mtg_heart]


id: GO:0003294
name: atrial ventricular junction remodeling
namespace: biological_process
def:
  "The reorganization or renovation of heart tissue that contributes to the maturation of the connection between an atrium and a ventricle." [GOC:mtg_heart]


id: GO:0003295
name: cell proliferation involved in atrial ventricular junction remodeling
namespace: biological_process
def:
  "The multiplication or reproduction of cells that contributes to the reorganization of tissue resulting in the maturation of the atrial ventricular junction." [GOC:mtg_heart]


id: GO:0003296
name: apoptotic process involved in atrial ventricular junction remodeling
namespace: biological_process
def:
  "Any apoptotic process that contributes to the reorganization of tissue resulting in the maturation of the atrial ventricular junction." [GOC:mtg_apoptosis, GOC:mtg_heart]


id: GO:0003297
name: heart wedging
namespace: biological_process
def:
  "The morphogenetic process in which the aorta inserts between the atrioventricular valves, contributing to the shaping of the heart." [GOC:mtg_heart]


id: GO:0003298
name: physiological muscle hypertrophy
namespace: biological_process
def:
  "The enlargement or overgrowth of all or part of a muscle organ or tissue due to an increase in the size of its muscle cells. Physiological hypertrophy is a normal process during development." [GOC:mtg_heart]


id: GO:0003299
name: muscle hypertrophy in response to stress
namespace: biological_process
def:
  "The enlargement or overgrowth of all or part of a muscle organ or tissue due to an increase in the size of its muscle cells as a result of a disturbance in organismal or cellular homeostasis." [GOC:mtg_heart]


id: GO:0003300
name: cardiac muscle hypertrophy
namespace: biological_process
def:
  "The enlargement or overgrowth of all or part of the heart muscle due to an increase in size of cardiac muscle cells without cell division." [GOC:mtg_heart]


id: GO:0003301
name: physiological cardiac muscle hypertrophy
namespace: biological_process
def:
  "The enlargement or overgrowth of all or part of the heart muscle due to an increase in size of cardiac muscle cells without cell division. This process contributes to the developmental growth of the heart." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:mtg_heart]


id: GO:0003302
name: transforming growth factor beta receptor signaling pathway involved in heart jogging
namespace: biological_process
def:
  "A series of molecular signals initiated by the binding of an extracellular ligand to a transforming growth factor beta receptor on the surface of a target cell, which contributes to the process of heart jogging." [GOC:mtg_heart, GOC:signaling]


id: GO:0003303
name: BMP signaling pathway involved in heart jogging
namespace: biological_process
def:
  "A series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, which contributes to the process of heart jogging." [GOC:mtg_heart]


id: GO:0003304
name: myocardial epithelial involution involved in heart jogging
namespace: biological_process
def:
  "The morphogenetic process in which the myocardium bends along a linear axis and contributes to the process of heart jogging." [GOC:mtg_heart]


id: GO:0003305
name: cell migration involved in heart jogging
namespace: biological_process
def:
  "The orderly movement of a cell of the myocardium from one site to another that will contribute to heart jogging." [GOC:mtg_heart]


id: GO:0003306
name: Wnt signaling pathway involved in heart development
namespace: biological_process
def:
  "The series of molecular signals initiated by binding of Wnt protein to a receptor on the surface of the target cell, resulting a change in cell state that contributes to the progression of the heart over time." [GOC:mtg_heart]


id: GO:0003307
name: regulation of Wnt signaling pathway involved in heart development
namespace: biological_process
def:
  "Any process that modulates the rate, frequency, or extent of the series of molecular signals initiated by binding of Wnt protein to a frizzled family receptor on the surface of the target cell, resulting a change in cell state that contributes to the progression of the heart over time." [GOC:mtg_heart]


id: GO:0003308
name: negative regulation of Wnt signaling pathway involved in heart development
namespace: biological_process
def:
  "Any process that decreases the rate, frequency, or extent of the series of molecular signals initiated by binding of Wnt protein to a frizzled family receptor on the surface of the target cell, resulting a change in cell state that contributes to the progression of the heart over time." [GOC:mtg_heart]


id: GO:0003309
name: type B pancreatic cell differentiation
namespace: biological_process
def:
  "The process in which relatively unspecialized cells acquire specialized structural and/or functional features of a type B pancreatic cell. A type B pancreatic cell is a cell located towards center of the islets of Langerhans that secretes insulin." [CL:0000169, GOC:dph, PMID:11076772]


id: GO:0003310
name: pancreatic A cell differentiation
namespace: biological_process
def:
  "The process in which relatively unspecialized cells acquire specialized structural and functional features of a pancreatic A cell. A pancreatic A cell is a cell in the pancreas that secretes glucagon." [GOC:dph, PMID:11076772]


id: GO:0003311
name: pancreatic D cell differentiation
namespace: biological_process
def:
  "The process in which relatively unspecialized cells acquire specialized structural and functional features that characterize a pancreatic delta cell. A delta cell is a cell of the pancreas that produces somatostatin." [GOC:dph, PMID:11076772]


id: GO:0003312
name: pancreatic PP cell differentiation
namespace: biological_process
def:
  "The process in which relatively unspecialized cells acquire specialized structural and functional features of a pancreatic polypeptide-producing cell. A pancreatic polypeptide-producing cell is a cell in the pancreas that produces pancreatic polypeptide." [GOC:dph, PMID:11076772]


id: GO:0003313
name: heart rudiment development
namespace: biological_process
def:
  "The progression of the heart rudiment over time, from its initial formation to the mature structure. The heart rudiment is a cone-like structure that is formed when myocardial progenitor cells of the heart field fuse at the midline. The heart rudiment is the first structure of the heart tube." [GOC:mtg_heart]


id: GO:0003314
name: heart rudiment morphogenesis
namespace: biological_process
def:
  "The process in which the anatomical structures of the heart rudiment are generated and organized." [GOC:mtg_heart]


id: GO:0003315
name: heart rudiment formation
namespace: biological_process
def:
  "The developmental process pertaining to the initial formation of the heart rudiment." [GOC:mtg_heart]


id: GO:0003316
name: establishment of myocardial progenitor cell apical/basal polarity
namespace: biological_process
def:
  "The specification and formation of the apicobasal polarity of an myocardial progenitor cell that contributes to the formation of the heart rudiment." [GOC:mtg_heart]


id: GO:0003317
name: cardioblast cell midline fusion
namespace: biological_process
def:
  "The attachment of cardiac progenitor cells to one another that contributes to the formation of the heart rudiment." [GOC:mtg_heart]


id: GO:0003318
name: cell migration to the midline involved in heart development
namespace: biological_process
def:
  "The orderly movement of a cell toward the midline that contributes to the progression of the heart over time." [GOC:mtg_heart]


id: GO:0003319
name: cardioblast migration to the midline involved in heart rudiment formation
namespace: biological_process
def:
  "The orderly movement of a cardioblast toward the midline that contributes to the initial appearance of the heart rudiment." [GOC:mtg_heart]


id: GO:0003320
name: heart rudiment involution
namespace: biological_process
def:
  "The inward folding of myocardial tissue derived from the right half of the heart rudiment that will form the future ventral part of the heart tube." [GOC:mtg_heart]


id: GO:0003321
name: positive regulation of blood pressure by epinephrine-norepinephrine
namespace: biological_process
def:
  "Any process in which the force of blood traveling through the circulatory system is increased by the chemicals epinephrine and norepinephrine." [GOC:dph]


