# TaxonomyIndex

NCBITaxonomyAccession: 36205
TaxonomyValue:
  Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; Eupercaria; Perciformes; Notothenioidei; Bovichtidae; Bovichtus


NCBITaxonomyAccession: 39708
TaxonomyValue:
  Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Papilionoidea; Nymphalidae; Nymphalinae; Junonia


NCBITaxonomyAccession: 1230541
TaxonomyValue:
  Eukaryota; Metazoa; Lophotrochozoa; Mollusca; Bivalvia; Heteroconchia; Euheterodonta; Veneroida; Tellinoidea; Tellinidae; Tellina


NCBITaxonomyAccession: 6688
TaxonomyValue:
  Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Crustacea; Malacostraca; Eumalacostraca; Eucarida; Decapoda; Dendrobranchiata; Penaeoidea; Penaeidae; unclassified 'Penaeus'


NCBITaxonomyAccession: 48498
TaxonomyValue:
  Eukaryota; Metazoa; Cnidaria; Anthozoa; Hexacorallia; Scleractinia; Faviina; Montastraeidae; Montastraea


NCBITaxonomyAccession: 1143368
TaxonomyValue:
  Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Scorpiones; Buthida; Buthoidea; Buthidae; Buthacus


NCBITaxonomyAccession: 31925
TaxonomyValue:
  Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Araneae; Araneomorphae; Haplogynae; Dysderoidea; Segestriidae; Segestria


NCBITaxonomyAccession: 38661
TaxonomyValue:
  Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Cyprinidae; Amblypharyngodon


NCBITaxonomyAccession: 51549
TaxonomyValue:
  Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Cyprinidae; Pseudorasbora


NCBITaxonomyAccession: 38762
TaxonomyValue:
  Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Cyprinidae; Tanichthys


NCBITaxonomyAccession: 588669
TaxonomyValue:
  Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliophyta; eudicotyledons; Gunneridae; Pentapetalae; asterids; campanulids; Asterales; Asteraceae; Asteroideae; Astereae; Australasian lineages; Aster


NCBITaxonomyAccession: 1301368
TaxonomyValue:
  Eukaryota; Metazoa; Cnidaria; Anthozoa; Hexacorallia; Actiniaria; Homostichanthidae; Homostichanthus


NCBITaxonomyAccession: 35933
TaxonomyValue:
  Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliophyta; eudicotyledons; Ranunculales; Berberidaceae; Podophylloideae; Podophyllum


NCBITaxonomyAccession: 862908
TaxonomyValue:
  Bacteria; Proteobacteria; Deltaproteobacteria; Bdellovibrionales; Halobacteriovoraceae; Halobacteriovorax


NCBITaxonomyAccession: 148304
TaxonomyValue:
  Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes; Sordariomycetidae; Magnaporthales; Magnaporthaceae; Magnaporthiopsis


NCBITaxonomyAccession: 179666
TaxonomyValue:
  Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Noctuoidea; Erebidae; Arctiinae; Tyria


NCBITaxonomyAccession: 59294
TaxonomyValue:
  Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliophyta; eudicotyledons; Gunneridae; Pentapetalae; asterids; campanulids; Asterales; Asteraceae; Asteroideae; Astereae; North American clade; Solidago


NCBITaxonomyAccession: 7293
TaxonomyValue:
  Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Chymomyza


NCBITaxonomyAccession: 45847
TaxonomyValue:
  Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes; Hypocreomycetidae; Hypocreales; Cordycipitaceae; Isaria


NCBITaxonomyAccession: 71160
TaxonomyValue:
  Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Myctophata; Myctophiformes; Myctophidae; Lampanyctus


NCBITaxonomyAccession: 99896
TaxonomyValue:
  Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes; Hypocreomycetidae; Hypocreales; Ophiocordycipitaceae; Polycephalomyces


NCBITaxonomyAccession: 74499
TaxonomyValue:
  Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Orbiliomycetes; Orbiliales; Orbiliaceae; mitosporic Orbiliaceae; Drechslerella


NCBITaxonomyAccession: 84645
TaxonomyValue:
  Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Cyprinidae; Labeo


NCBITaxonomyAccession: 8187
TaxonomyValue:
  Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; Carangaria; Carangiaria incertae sedis; Centropomidae; Lates


NCBITaxonomyAccession: 103866
TaxonomyValue:
  Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; Ovalentaria; Atherinomorphae; Atheriniformes; Atherinopsidae; Atherinopsinae; Odontesthes


NCBITaxonomyAccession: 30993
TaxonomyValue:
  Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Siluriformes; Pangasiidae; Pangasianodon


NCBITaxonomyAccession: 8001
TaxonomyValue:
  Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Siluriformes; Pangasiidae; Pangasius


NCBITaxonomyAccession: 349646
TaxonomyValue:
  Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; Carangaria; Carangiformes; Carangidae; Pseudocaranx


NCBITaxonomyAccession: 76340
TaxonomyValue:
  Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; Eupercaria; Sciaenidae; Sciaenops


NCBITaxonomyAccession: 214486
TaxonomyValue:
  Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; Eupercaria; Perciformes; Scorpaenoidei; Sebastidae; Sebastinae; Sebastes


NCBITaxonomyAccession: 8103
TaxonomyValue:
  Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; Eupercaria; Perciformes; Cottioidei; Cottales; Cyclopteridae; Cyclopterus


NCBITaxonomyAccession: 5597
TaxonomyValue:
  Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes; Hypocreomycetidae; Microascales; Microascaceae; Scedosporium


NCBITaxonomyAccession: 1522
TaxonomyValue:
  Bacteria; Firmicutes; Erysipelotrichia; Erysipelotrichales; Erysipelotrichaceae; Erysipelatoclostridium


NCBITaxonomyAccession: 756982
TaxonomyValue:
  Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Orbiliomycetes; Orbiliales; Orbiliaceae; Orbilia


NCBITaxonomyAccession: 115113
TaxonomyValue:
  Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Orthopteroidea; Dictyoptera; Isoptera; Termitidae; Macrotermitinae; Pseudacanthotermes


NCBITaxonomyAccession: 666126
TaxonomyValue:
  Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Araneae; Araneomorphae; Entelegynae; Lycosoidea; Oxyopidae; Oxyopes


NCBITaxonomyAccession: 1088058
TaxonomyValue:
  Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia; Pecora; Cervidae; Cervinae; Przewalskium


NCBITaxonomyAccession: 340056
TaxonomyValue:
  Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Noctuoidea; Erebidae; Arctiinae; Amsacta


NCBITaxonomyAccession: 145953
TaxonomyValue:
  Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliophyta; Liliopsida; Asparagales; Orchidaceae; Orchidoideae; Orchideae; Orchidinae; Ophrys


NCBITaxonomyAccession: 4013
TaxonomyValue:
  Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliophyta; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Sapindales; Anacardiaceae; Toxicodendron


NCBITaxonomyAccession: 79022
TaxonomyValue:
  Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliophyta; eudicotyledons; Gunneridae; Pentapetalae; asterids; campanulids; Apiales; Apiaceae; Apioideae; Scandiceae; Daucinae; Thapsia


NCBITaxonomyAccession: 13279
TaxonomyValue:
  Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; Eupercaria; Perciformes; Scorpaenoidei; Synanceiidae; Synanceiinae; Synanceia


NCBITaxonomyAccession: 658429
TaxonomyValue:
  Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes; Leotiomycetes incertae sedis; Pseudeurotiaceae; Pseudogymnoascus


NCBITaxonomyAccession: 36166
TaxonomyValue:
  Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Platypezoidea; Phoridae; Megaseliini; Megaselia


NCBITaxonomyAccession: 34553
TaxonomyValue:
  Eukaryota; Metazoa; Lophotrochozoa; Mollusca; Cephalopoda; Coleoidea; Neocoleoidea; Decapodiformes; Teuthida; Oegopsina; Ommastrephidae; Sthenoteuthis


NCBITaxonomyAccession: 10172
TaxonomyValue:
  Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Hystricognathi; Bathyergidae; Bathyergus


NCBITaxonomyAccession: 185217
TaxonomyValue:
  Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Araneae; Araneomorphae; Entelegynae; Amaurobiidae; Pireneitega


NCBITaxonomyAccession: 293813
TaxonomyValue:
  Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Araneae; Araneomorphae; Entelegynae; Agelenidae; Agelena


NCBITaxonomyAccession: 6910
TaxonomyValue:
  Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Araneae; Araneomorphae; Entelegynae; Agelenidae; Hololena


NCBITaxonomyAccession: 278061
TaxonomyValue:
  Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Araneae; Mygalomorphae; Hexathelidae; Hadronyche


NCBITaxonomyAccession: 5217
TaxonomyValue:
  Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes; Tremellales; Tremellaceae; Tremella


NCBITaxonomyAccession: 65494
TaxonomyValue:
  Eukaryota; Metazoa; Lophotrochozoa; Annelida; Polychaeta; Palpata; Aciculata; Eunicida; Oenonidae; Arabella


NCBITaxonomyAccession: 5261
TaxonomyValue:
  Eukaryota; Fungi; Dikarya; Basidiomycota; Pucciniomycotina; Pucciniomycetes; Pucciniales; Melampsoraceae; Melampsora


NCBITaxonomyAccession: 64363
TaxonomyValue:
  Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Dothideomycetes; Dothideomycetidae; Capnodiales; Mycosphaerellaceae; Dothistroma


NCBITaxonomyAccession: 85828
TaxonomyValue:
  Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes; Xylariomycetidae; Xylariales; Amphisphaeriaceae; Pestalotiopsis


NCBITaxonomyAccession: 3050
TaxonomyValue:
  Eukaryota; Viridiplantae; Chlorophyta; Chlorophyceae; Chlamydomonadales; Chlamydomonadaceae; Polytomella


NCBITaxonomyAccession: 38038
TaxonomyValue:
  Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes; Helotiales; mitosporic Helotiales; Rhynchosporium


NCBITaxonomyAccession: 5272
TaxonomyValue:
  Eukaryota; Fungi; Dikarya; Basidiomycota; Pucciniomycotina; Microbotryomycetes; Microbotryales; Microbotryaceae; Microbotryum


NCBITaxonomyAccession: 58228
TaxonomyValue:
  Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliophyta; eudicotyledons; Gunneridae; Pentapetalae; rosids; fabids; Malpighiales; Clusiaceae; Garcinieae; Garcinia


NCBITaxonomyAccession: 8164
TaxonomyValue:
  Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; Eupercaria; Pempheriformes; Lateolabracidae; Lateolabrax


NCBITaxonomyAccession: 230234
TaxonomyValue:
  Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Araneae; Mygalomorphae; Actinopodidae; Missulena


NCBITaxonomyAccession: 745793
TaxonomyValue:
  Eukaryota; Metazoa; Lophotrochozoa; Mollusca; Gastropoda; Caenogastropoda; Hypsogastropoda; Neogastropoda; Conoidea; Terebridae; Hastula


NCBITaxonomyAccession: 8389
TaxonomyValue:
  Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Neobatrachia; Hyloidea; Bufonidae; Anaxyrus


NCBITaxonomyAccession: 29025
TaxonomyValue:
  Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Paraneoptera; Hemiptera; Euhemiptera; Heteroptera; Panheteroptera; Pentatomomorpha; Pentatomoidea; Pentatomidae; Asopinae; Podisus


NCBITaxonomyAccession: 42757
TaxonomyValue:
  Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Caudata; Salamandroidea; Proteidae; Necturus


NCBITaxonomyAccession: 5041
TaxonomyValue:
  Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes; Eurotiomycetidae; Onygenales; mitosporic Onygenales; Malbranchea


NCBITaxonomyAccession: 4621
TaxonomyValue:
  Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliophyta; Liliopsida; Zingiberales; Marantaceae; Thaumatococcus


NCBITaxonomyAccession: 3968
TaxonomyValue:
  Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliophyta; eudicotyledons; Gunneridae; Pentapetalae; Santalales; Viscaceae; Phoradendron


NCBITaxonomyAccession: 171899
TaxonomyValue:
  Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliophyta; eudicotyledons; Ranunculales; Ranunculaceae; Ranunculoideae; Helleboreae; Helleborus


NCBITaxonomyAccession: 3960
TaxonomyValue:
  Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliophyta; eudicotyledons; Gunneridae; Pentapetalae; Santalales; Cervantesiaceae; Pyrularia


NCBITaxonomyAccession: 103373
TaxonomyValue:
  Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Neobatrachia; Ranoidea; Dicroglossidae; Dicroglossinae; Hoplobatrachus


NCBITaxonomyAccession: 202477
TaxonomyValue:
  Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliophyta; eudicotyledons; Gunneridae; Pentapetalae; asterids; lamiids; Lamiales; Plantaginaceae; Veroniceae; Veronica; Cochlidiosperma


NCBITaxonomyAccession: 1258720
TaxonomyValue:
  Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Neobatrachia; Ranoidea; Rhacophoridae; Rhacophorinae; Theloderma


NCBITaxonomyAccession: 104953
TaxonomyValue:
  Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Neobatrachia; Myobatrachoidea; Myobatrachidae; Myobatrachinae; Uperoleia


NCBITaxonomyAccession: 420151
TaxonomyValue:
  Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Araneae; Araneomorphae; Entelegynae; Lycosoidea; Lycosidae; Geolycosa


NCBITaxonomyAccession: 99038
TaxonomyValue:
  Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliophyta; eudicotyledons; Gunneridae; Pentapetalae; asterids; campanulids; Asterales; Asteraceae; Asteroideae; Anthemideae; Artemisiinae; Glebionis


NCBITaxonomyAccession: 279180
TaxonomyValue:
  Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliophyta; eudicotyledons; Gunneridae; Pentapetalae; rosids; fabids; Fagales; Fagaceae; Castanopsis


NCBITaxonomyAccession: 6678
TaxonomyValue:
  Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Crustacea; Maxillopoda; Cirripedia; Thoracica; Sessilia; Balanidae; Balanus


NCBITaxonomyAccession: 6903
TaxonomyValue:
  Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Araneae; Mygalomorphae; Hexathelidae; Atrax


NCBITaxonomyAccession: 28511
TaxonomyValue:
  Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliophyta; eudicotyledons; Gunneridae; Pentapetalae; asterids; lamiids; Lamiales; Lamiaceae; Lamioideae; Pogostemoneae; Pogostemon


NCBITaxonomyAccession: 55967
TaxonomyValue:
  Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae; Culicinae; Aedini; Aedes; Finlaya


NCBITaxonomyAccession: 106276
TaxonomyValue:
  Eukaryota; Metazoa; Lophotrochozoa; Mollusca; Bivalvia; Pteriomorphia; Pectinoida; Pectinoidea; Pectinidae; Mimachlamys


NCBITaxonomyAccession: 127986
TaxonomyValue:
  Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliophyta; eudicotyledons; Gunneridae; Pentapetalae; asterids; campanulids; Asterales; Asteraceae; Asteroideae; Anthemideae; Matricariinae; Matricaria


NCBITaxonomyAccession: 542674
TaxonomyValue:
  Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliophyta; eudicotyledons; Gunneridae; Pentapetalae; asterids; lamiids; Lamiales; Verbenaceae; Lantaneae; Phyla


NCBITaxonomyAccession: 19953
TaxonomyValue:
  Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliophyta; eudicotyledons; Gunneridae; Pentapetalae; asterids; campanulids; Dipsacales; Caprifoliaceae; Valeriana


NCBITaxonomyAccession: 319348
TaxonomyValue:
  Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Nematocera; Chironomoidea; Chironomidae; Chironominae; Polypedilum


NCBITaxonomyAccession: 74722
TaxonomyValue:
  Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes; Hypocreomycetidae; Hypocreales; Stachybotriaceae; Stachybotrys


NCBITaxonomyAccession: 204129
TaxonomyValue:
  Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliophyta; eudicotyledons; Gunneridae; Pentapetalae; asterids; lamiids; Lamiales; Lamiaceae; Nepetoideae; Ocimeae; Hyptis


NCBITaxonomyAccession: 270110
TaxonomyValue:
  Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliophyta; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Cochlearieae; Cochlearia


NCBITaxonomyAccession: 205877
TaxonomyValue:
  Viruses; dsDNA viruses, no RNA stage; Caudovirales; Myoviridae; I3likevirus; unclassified I3-like viruses


NCBITaxonomyAccession: 439598
TaxonomyValue:
  Eukaryota; Metazoa; Lophotrochozoa; Mollusca; Gastropoda; Caenogastropoda; Hypsogastropoda; Neogastropoda; Conoidea; Turridae; Lophiotoma


NCBITaxonomyAccession: 1525239
TaxonomyValue:
  Eukaryota; Metazoa; Lophotrochozoa; Mollusca; Gastropoda; Caenogastropoda; Hypsogastropoda; Neogastropoda; Conoidea; Turridae; Xenuroturris


NCBITaxonomyAccession: 553733
TaxonomyValue:
  Eukaryota; Metazoa; Lophotrochozoa; Mollusca; Gastropoda; Caenogastropoda; Hypsogastropoda; Neogastropoda; Conoidea; Turridae; Iotyrris


NCBITaxonomyAccession: 394106
TaxonomyValue:
  Eukaryota; Metazoa; Lophotrochozoa; Mollusca; Gastropoda; Caenogastropoda; Hypsogastropoda; Neogastropoda; Conoidea; Turridae; Polystira


NCBITaxonomyAccession: 609289
TaxonomyValue:
  Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Vespoidea; Formicidae; Ponerinae; Ponerini; Dinoponera


NCBITaxonomyAccession: 268415
TaxonomyValue:
  Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Araneae; Araneomorphae; Haplogynae; Filistatidae; Kukulcania


NCBITaxonomyAccession: 316287
TaxonomyValue:
  Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Araneae; Mygalomorphae; Theraphosidae; Ceratogyrus


NCBITaxonomyAccession: 682790
TaxonomyValue:
  Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Araneae; Araneomorphae; Entelegynae; Entelegynae incertae sedis; Miturgidae; Cheiracanthium


NCBITaxonomyAccession: 268413
TaxonomyValue:
  Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Araneae; Mygalomorphae; Theraphosidae; Heteroscodra


NCBITaxonomyAccession: 179874
TaxonomyValue:
  Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Araneae; Mygalomorphae; Theraphosidae; Psalmopoeus


NCBITaxonomyAccession: 1395661
TaxonomyValue:
  Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Araneae; Mygalomorphae; Theraphosidae; Selenotypus


NCBITaxonomyAccession: 269628
TaxonomyValue:
  Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Araneae; Mygalomorphae; Theraphosidae; Stromatopelma


NCBITaxonomyAccession: 260533
TaxonomyValue:
  Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Araneae; Mygalomorphae; Theraphosidae; Theraphosa


NCBITaxonomyAccession: 269635
TaxonomyValue:
  Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Araneae; Mygalomorphae; Theraphosidae; Paraphysa


NCBITaxonomyAccession: 118972
TaxonomyValue:
  Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Araneae; Mygalomorphae; Theraphosidae; Hysterocrates


NCBITaxonomyAccession: 152925
TaxonomyValue:
  Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Araneae; Araneomorphae; Entelegynae; Dionycha; Sparassidae; Heteropoda


NCBITaxonomyAccession: 256750
TaxonomyValue:
  Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Araneae; Araneomorphae; Entelegynae; Araneoidea; Theridiidae; Steatoda


NCBITaxonomyAccession: 29934
TaxonomyValue:
  Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Araneae; Araneomorphae; Entelegynae; Agelenidae; Allagelena


NCBITaxonomyAccession: 54074
TaxonomyValue:
  Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Araneae; Mygalomorphae; Theraphosidae; Brachypelma


NCBITaxonomyAccession: 172846
TaxonomyValue:
  Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Araneae; Araneomorphae; Entelegynae; Araneoidea; Araneidae; Caerostris


NCBITaxonomyAccession: 33319
TaxonomyValue:
  Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Araneae; Araneomorphae; Haplogynae; Plectreuridae; Plectreurys


NCBITaxonomyAccession: 504442
TaxonomyValue:
  Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Araneae; Araneomorphae; Entelegynae; Dionycha; Thomisidae; Heriaeus


NCBITaxonomyAccession: 38407
TaxonomyValue:
  Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Araneae; Araneomorphae; Haplogynae; Diguetidae; Diguetia


NCBITaxonomyAccession: 1686644
TaxonomyValue:
  Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Araneae; Araneomorphae; Entelegynae; Agelenidae; Eratigena


NCBITaxonomyAccession: 268490
TaxonomyValue:
  Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Araneae; Mygalomorphae; Theraphosidae; Lasiodora


NCBITaxonomyAccession: 223896
TaxonomyValue:
  Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Araneae; Mygalomorphae; Hexathelidae; Macrothele


NCBITaxonomyAccession: 753628
TaxonomyValue:
  Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Araneae; Mygalomorphae; Theraphosidae; Pelinobius


NCBITaxonomyAccession: 12944
TaxonomyValue:
  Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Araneae; Mygalomorphae; Euctenizidae; Apomastus


NCBITaxonomyAccession: 6950
TaxonomyValue:
  Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Acari; Acariformes; Trombidiformes; Prostigmata; Eleutherengona; Heterostigmata; Pyemotoidea; Pyemotidae; Pyemotes


NCBITaxonomyAccession: 129522
TaxonomyValue:
  Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Araneae; Mygalomorphae; Theraphosidae; Coremiocnemis


NCBITaxonomyAccession: 9006
TaxonomyValue:
  Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae


NCBITaxonomyAccession: 61267
TaxonomyValue:
  Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes; Agaricomycetidae; Agaricales; Strophariaceae; Pholiota


NCBITaxonomyAccession: 41492
TaxonomyValue:
  Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliophyta; eudicotyledons; Gunneridae; Pentapetalae; asterids; campanulids; Asterales; Asteraceae; Asteroideae; Astereae; Astereae incertae sedis; Bellis


NCBITaxonomyAccession: 114476
TaxonomyValue:
  Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliophyta; eudicotyledons; Gunneridae; Pentapetalae; asterids; lamiids; Gentianales; Rubiaceae; Ixoroideae; Gardenieae; Gardenia


NCBITaxonomyAccession: 175648
TaxonomyValue:
  Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Agaricomycetes; Hymenochaetales; Hymenochaetaceae; Phellinidium


NCBITaxonomyAccession: 194527
TaxonomyValue:
  Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Gymnophiona; Ichthyophiidae; Ichthyophis


NCBITaxonomyAccession: 230081
TaxonomyValue:
  Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi; Muroidea; Cricetidae; Neotominae; Neotomodon


NCBITaxonomyAccession: 165561
TaxonomyValue:
  Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Hymenoptera; Apocrita; Ichneumonoidea; Braconidae; Euphorinae; Microctonus


NCBITaxonomyAccession: 522437
TaxonomyValue:
  Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Vespoidea; Vespidae; Eumeninae; Rhynchium


NCBITaxonomyAccession: 226809
TaxonomyValue:
  Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Tabanomorpha; Tabanoidea; Tabanidae; Hybomitra


NCBITaxonomyAccession: 81901
TaxonomyValue:
  Eukaryota; Metazoa; Lophotrochozoa; Mollusca; Gastropoda; Vetigastropoda; Trochoidea; Trochidae; Omphalius


NCBITaxonomyAccession: 10577
TaxonomyValue:
  Viruses; dsDNA viruses, no RNA stage; Papillomaviridae; Etapapillomavirus; unclassified Etapapillomavirus


NCBITaxonomyAccession: 30308
TaxonomyValue:
  Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Cyclostomata; Hyperoartia; Petromyzontiformes; Petromyzontidae; Ichthyomyzon


NCBITaxonomyAccession: 1260276
TaxonomyValue:
  Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera; Serpentes; Colubroidea; Dipsadidae; Borikenophis


NCBITaxonomyAccession: 110218
TaxonomyValue:
  Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera; Serpentes; Colubroidea; Viperidae; Viperinae; Proatheris


NCBITaxonomyAccession: 108749
TaxonomyValue:
  Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Hymenoptera; Apocrita; Chalcidoidea; Eulophidae; Eulophinae; Eulophus


NCBITaxonomyAccession: 547193
TaxonomyValue:
  Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Araneae; Araneomorphae; Entelegynae; Lycosoidea; Lycosidae; Hippasa


NCBITaxonomyAccession: 662117
TaxonomyValue:
  Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Scorpiones; Iurida; Chactoidea; Chactidae; Brotheinae; Brotheini; Brotheina; Brotheas


NCBITaxonomyAccession: 7852
TaxonomyValue:
  Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Chondrichthyes; Elasmobranchii; Galeomorphii; Galeoidea; Lamniformes; Alopiidae; Alopias


NCBITaxonomyAccession: 7616
TaxonomyValue:
  Eukaryota; Metazoa; Echinodermata; Eleutherozoa; Asterozoa; Asteroidea; Forcipulatacea; Forcipulatida; Asteriidae; Evasterias


NCBITaxonomyAccession: 8595
TaxonomyValue:
  Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera; Serpentes; Colubroidea; Colubridae; Colubrinae; Pituophis


NCBITaxonomyAccession: 463545
TaxonomyValue:
  Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Lepidosauria; Squamata; Bifurcata; Unidentata; Scinciformata; Scincidae; Scincinae; Plestiodon


NCBITaxonomyAccession: 45596
TaxonomyValue:
  Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Debaryomycetaceae; Yamadazyma; Yamadazyma/Candida clade


NCBITaxonomyAccession: 264951
TaxonomyValue:
  Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes; Eurotiomycetidae; Eurotiales; Thermoascaceae; Byssochlamys


NCBITaxonomyAccession: 100951
TaxonomyValue:
  Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes; Filobasidiales; Filobasidiaceae; Cryptococcus


NCBITaxonomyAccession: 5087
TaxonomyValue:
  Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes; Eurotiomycetidae; Eurotiales; Thermoascaceae; Thermoascus


NCBITaxonomyAccession: 6347
TaxonomyValue:
  Eukaryota; Metazoa; Lophotrochozoa; Annelida; Polychaeta; Palpata; Canalipalpata; Sabellida; Oweniida; Oweniidae; Owenia


NCBITaxonomyAccession: 27706
TaxonomyValue:
  Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata; Eupercaria; Centrarchiformes; Centrarchoidei; Centrarchidae; Micropterus


# eggNOGIndex

eggNOGIndexTerm: COG5153
eggNOGDescriptionValue:
  Lipase which is essential for lysis of subvacuolar cytoplasm to vacuole targeted bodies and intravacuolar autophagic bodies. Involved in the lysis of intravacuolar multivesicular body (MVB) vesicles. The intravacuolar membrane disintegration by ATG15 is critical to life span extension (By similarity)


eggNOGIndexTerm: COG0653
eggNOGDescriptionValue:
  Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving


eggNOGIndexTerm: COG1932
eggNOGDescriptionValue:
  Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity)


eggNOGIndexTerm: ENOG410ZDFZ
eggNOGDescriptionValue:
  BEST Arabidopsis thaliana protein match is oxidoreductase, acting on NADH or NADPH (TAIR AT1G75260.1)


eggNOGIndexTerm: ENOG410ZB2Z
eggNOGDescriptionValue:
  Contributes to surface hydrophobicity, which is important for processes such as association of hyphae in reproductive structures, dispersal of aerial spores and adhesion of pathogens to host structures


eggNOGIndexTerm: ENOG4111QQF
eggNOGDescriptionValue:
  Involved in the degradation and recycling of damaged RNA. It is itself a target for degradation by the ATP-dependent protease La (By similarity)


eggNOGIndexTerm: COG1057
eggNOGDescriptionValue:
  Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity)


eggNOGIndexTerm: COG1059
eggNOGDescriptionValue:
  Responsible for removing an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine 7-oxoG) from DNA. Also nicks DNA at apurinic apyrimidinic sites (AP sites) (By similarity)


eggNOGIndexTerm: ENOG41119SX
eggNOGDescriptionValue:
  Cytokine that stimulates the proliferation of T- lymphocytes. Stimulation by IL-15 requires interaction of IL-15 with components of IL-2R, including IL-2R beta and probably IL-2R gamma but not IL-2R alpha


eggNOGIndexTerm: ENOG41119SW
eggNOGDescriptionValue:
  Involved in sporulation and maintenance of the mitochondrial DNA. Is probably involved in a pathway contributing to genomic integrity (By similarity)


eggNOGIndexTerm: COG1185
eggNOGDescriptionValue:
  Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity)


eggNOGIndexTerm: COG1186
eggNOGDescriptionValue:
  Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity)


eggNOGIndexTerm: COG1182
eggNOGDescriptionValue:
  Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity)


eggNOGIndexTerm: COG0132
eggNOGDescriptionValue:
  Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity)


eggNOGIndexTerm: COG0133
eggNOGDescriptionValue:
  The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity)


eggNOGIndexTerm: COG0130
eggNOGDescriptionValue:
  Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity)


eggNOGIndexTerm: COG0136
eggNOGDescriptionValue:
  Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity)


eggNOGIndexTerm: ENOG410Y43K
eggNOGDescriptionValue:
  Regulatory subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA (By similarity)


eggNOGIndexTerm: ENOG4110MI8
eggNOGDescriptionValue:
  Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod (By similarity)


eggNOGIndexTerm: ENOG4111S4N
eggNOGDescriptionValue:
  Component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner


eggNOGIndexTerm: COG4370
eggNOGDescriptionValue:
  Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity)


eggNOGIndexTerm: ENOG410ZSK1
eggNOGDescriptionValue:
  Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity)


eggNOGIndexTerm: ENOG410Z40H
eggNOGDescriptionValue:
  Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2 ), Na( ), K( ), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80 of all plasma zinc


eggNOGIndexTerm: ENOG410YKVT
eggNOGDescriptionValue:
  Involved in the biosynthesis of the arabinogalactan (AG) region of the mycolylarabinogalactan-peptidoglycan (mAGP) complex, an essential component the mycobacterial cell wall. Catalyzes the transfer of arabinofuranosyl (Araf) residues residue from the sugar donor beta-D-arabinofuranosyl-1-monophosphoryldecaprenol (DPA) to the arabinan domain to form terminal beta-(1- 2)-linked Araf residues, which marks the end point for AG arabinan biosynthesis before decoration with mycolic acids


eggNOGIndexTerm: ENOG4111IYK
eggNOGDescriptionValue:
  Pectinolytic enzymes consist of four classes of enzymes pectin lyase, polygalacturonase, pectin methylesterase and rhamnogalacturonase. Among pectinolytic enzymes, pectin lyase is the most important in depolymerization of pectin, since it cleaves internal glycosidic bonds of highly methylated pectins


eggNOGIndexTerm: ENOG4111FPC
eggNOGDescriptionValue:
  these effects are overcome by concomitant expression of antitoxin SohA (PrlF). Massive overexpression is toxic. Unlike most other characterized TA systems degrades rRNA, and co-folding of the proteins is necessary in vitro for inhibition of the RNase activity. It is not known if it has any sequence-specificity. Acts as a transcription factor. The YhaV PrlF complex binds the prlF-yhaV operon, probably negatively regulating its expression


eggNOGIndexTerm: COG2128
eggNOGDescriptionValue:
  Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity)


eggNOGIndexTerm: ENOG4111Q9Z
eggNOGDescriptionValue:
  Histones H3 and H4 chaperone involved in the nucleosome formation and heterochromatin silencing. Required for the deposition of H3K56ac-carrying H3-H4 complex onto newly-replicated DNA. Plays a role in the transcriptional regulation of the cell- cycle dependent histone genes by creating a repressive structure at the core histone gene promoter (By similarity)


eggNOGIndexTerm: ENOG411266C
eggNOGDescriptionValue:
  structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA


eggNOGIndexTerm: COG1788
eggNOGDescriptionValue:
  Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate (By similarity)


eggNOGIndexTerm: ENOG410ZCDZ
eggNOGDescriptionValue:
  DNA-binding protein that specifically recognizes a negative element (S1F) within the RPS1 promoter (By similarity)


eggNOGIndexTerm: COG0373
eggNOGDescriptionValue:
  Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity)


eggNOGIndexTerm: COG0377
eggNOGDescriptionValue:
  NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)


eggNOGIndexTerm: COG0378
eggNOGDescriptionValue:
  Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG (By similarity)


eggNOGIndexTerm: COG0379
eggNOGDescriptionValue:
  Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity)


eggNOGIndexTerm: ENOG410XTWK
eggNOGDescriptionValue:
  positive regulation by organism of immune response of other organism involved in symbiotic interaction


eggNOGIndexTerm: COG3857
eggNOGDescriptionValue:
  The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination


eggNOGIndexTerm: ENOG410XPVH
eggNOGDescriptionValue:
  DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs


eggNOGIndexTerm: ENOG410XPVQ
eggNOGDescriptionValue:
  Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME) (By similarity)


eggNOGIndexTerm: ENOG410XPQ8
eggNOGDescriptionValue:
  The proteasome is a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity (By similarity)


eggNOGIndexTerm: ENOG410XPQM
eggNOGDescriptionValue:
  Catalyzes the first step in the conversion of phosphatidylethanolamine to phosphatidylcholine during the methylation pathway of phosphatidylcholine biosynthesis (By similarity)


eggNOGIndexTerm: ENOG41118JP
eggNOGDescriptionValue:
  Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions. PetL is important for photoautotrophic growth as well as for electron transfer efficiency and stability of the cytochrome b6-f complex (By similarity)


eggNOGIndexTerm: ENOG410ZV70
eggNOGDescriptionValue:
  Protein modifier that is covalently attached to lysine residues of substrate proteins, thereby targeting them for proteasomal degradation. The tagging system is termed pupylation (By similarity)


eggNOGIndexTerm: COG2063
eggNOGDescriptionValue:
  Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity)


eggNOGIndexTerm: COG2060
eggNOGDescriptionValue:
  One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity)


eggNOGIndexTerm: COG1290
eggNOGDescriptionValue:
  Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis (By similarity)


eggNOGIndexTerm: ENOG410ZZR8
eggNOGDescriptionValue:
  Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions. PetG is required for either the stability or assembly of the cytochrome b6-f complex (By similarity)


eggNOGIndexTerm: ENOG4111MXA
eggNOGDescriptionValue:
  Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity)


eggNOGIndexTerm: ENOG410ZGHJ
eggNOGDescriptionValue:
  Interleukin 12A (Natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35)


eggNOGIndexTerm: ENOG410ZM9E
eggNOGDescriptionValue:
  Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity)


eggNOGIndexTerm: ENOG410XNUJ
eggNOGDescriptionValue:
  The 2-keto-3-deoxygluconate permease transports the degraded pectin products into the bacterial cell, where they serve as carbon and energy sources. This is a hydrogen coupled transport system (By similarity)


eggNOGIndexTerm: ENOG410XS9E
eggNOGDescriptionValue:
  Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)


eggNOGIndexTerm: COG3474
eggNOGDescriptionValue:
  Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain


eggNOGIndexTerm: COG1859
eggNOGDescriptionValue:
  Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP- ribose 1''-2''-cyclic phosphate (APPR P). May function as an ADP- ribosylase (By similarity)


eggNOGIndexTerm: COG1854
eggNOGDescriptionValue:
  Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity)


eggNOGIndexTerm: COG1850
eggNOGDescriptionValue:
  RuBisCO catalyzes two reactions the carboxylation of D- ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate


eggNOGIndexTerm: ENOG4111UV9
eggNOGDescriptionValue:
  protein from Francisella novicida (262 aa), BLAST Score 443 bits (1140), Expect e-12 Identities 229 262 (87),Positives 235 262 (89)


eggNOGIndexTerm: ENOG41119SF
eggNOGDescriptionValue:
  Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine- activated killer cells, natural killer cells, and glioma cells


eggNOGIndexTerm: ENOG4112BGR
eggNOGDescriptionValue:
  Subunit of malonate decarboxylase, it is an acyl carrier protein to which acetyl and malonyl thioester residues are bound via a 2'-(5''-phosphoribosyl)-3'-dephospho-CoA prosthetic group and turn over during the catalytic mechanism (By similarity)


eggNOGIndexTerm: COG0661
eggNOGDescriptionValue:
  Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity)


eggNOGIndexTerm: COG0669
eggNOGDescriptionValue:
  Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity)


eggNOGIndexTerm: COG0141
eggNOGDescriptionValue:
  Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity)


eggNOGIndexTerm: COG4451
eggNOGDescriptionValue:
  RuBisCO catalyzes two reactions the carboxylation of D- ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate. Both reactions occur simultaneously and in competition at the same active site


eggNOGIndexTerm: ENOG410XUS9
eggNOGDescriptionValue:
  Acts as a sulfur carrier required for molybdopterin biosynthesis. Component of the molybdopterin synthase complex that catalyzes the conversion of precursor Z into molybdopterin by mediating the incorporation of 2 sulfur atoms into precursor Z to generate a dithiolene group. In the complex, serves as sulfur donor by being thiocarboxylated (-COSH) at its C-terminus by MOCS3. After interaction with MOCS2B, the sulfur is then transferred to precursor Z to form molybdopterin (By similarity)


eggNOGIndexTerm: ENOG410Y9UB
eggNOGDescriptionValue:
  Involved in the organization of the mitochondrial membranes and the global structure of the mitochondria. Also required for mitochondrial distribution and mobility as well as for the maintenance of mitochondrial DNA nucleoids structures (By similarity)


eggNOGIndexTerm: COG5196
eggNOGDescriptionValue:
  Required for the retention of luminal endoplasmic reticulum proteins. Determines the specificity of the luminal ER protein retention system. Also required for normal vesicular traffic through the Golgi (By similarity)


eggNOGIndexTerm: COG0617
eggNOGDescriptionValue:
  Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate


eggNOGIndexTerm: COG0611
eggNOGDescriptionValue:
  Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity)


eggNOGIndexTerm: ENOG4111TPB
eggNOGDescriptionValue:
  Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity)


eggNOGIndexTerm: ENOG410YPG7
eggNOGDescriptionValue:
  Interacts with a short DNA sequence about one-quarter of the way into the major capsid protein gene 23 of T4, and the inhibition occurs when this late gene of the virus is expressed


eggNOGIndexTerm: ENOG4112BZI
eggNOGDescriptionValue:
  Rod linker protein, associated with phycocyanin. Linker polypeptides determine the state of aggregation and the location of the disk-shaped phycobiliprotein units within the phycobilisome and modulate their spectroscopic properties in order to mediate a directed and optimal energy transfer


eggNOGIndexTerm: ENOG410Z7IB
eggNOGDescriptionValue:
  Aminoacyl carrier protein. Can be charged with L-glycine via the formation of a thioester bond between the amino acid and the 4'-phosphopantetheinyl prosthetic group, catalyzed by the


eggNOGIndexTerm: ENOG410ZVHP
eggNOGDescriptionValue:
  involved in the repression of many genes in a wide variety of physiological processes. May also be involved in the derepression of at least some target genes. The complex is recruited to target genes by interaction with DNA-bound transcriptional repressors. The complex recruits histone deacetylases to produce a repressive chromatin structure, interacts with hypoacetylated N-terminal tails of histones H3 and H4 that have been programmed for repression by the action of histone deacetylases and interferes directly with the transcriptional machinery by associating with the RNA polymerase II mediator complex (By similarity)


eggNOGIndexTerm: COG3599
eggNOGDescriptionValue:
  Divisome component that associates with the complex late in its assembly, after the Z-ring is formed, and is dependent on DivIC and PBP2B for its recruitment to the divisome. Together with EzrA, is a key component of the system that regulates PBP1 localization during cell cycle progression. Its main role could be the removal of PBP1 from the cell pole after pole maturation is completed. Also contributes to the recruitment of PBP1 to the division complex. Not essential for septum formation (By similarity)


eggNOGIndexTerm: COG4061
eggNOGDescriptionValue:
  Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step (By similarity)


eggNOGIndexTerm: ENOG4111QUH
eggNOGDescriptionValue:
  sty2063 SWALL Q8Z5Z8 (EMBL AL627272) (262 aa) fasta scores E() 1.5e-07, 24.43 id in 266 aa, and to Escherichia coli O157 H7


eggNOGIndexTerm: ENOG410XTXX
eggNOGDescriptionValue:
  Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity)


eggNOGIndexTerm: COG1094
eggNOGDescriptionValue:
  Required for 40S ribosome biogenesis. Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly (By similarity)


eggNOGIndexTerm: ENOG410Y5ZV
eggNOGDescriptionValue:
  Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis (By similarity)


eggNOGIndexTerm: ENOG4111BK3
eggNOGDescriptionValue:
  Involved in extracellular amino acid uptake. Required for the protein trafficking from the Golgi to the plasma membrane (By similarity)


eggNOGIndexTerm: ENOG410Y5FP
eggNOGDescriptionValue:
  Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division (By similarity)


eggNOGIndexTerm: ENOG4111TMY
eggNOGDescriptionValue:
  Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity)


eggNOGIndexTerm: COG0178
eggNOGDescriptionValue:
  The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity)


eggNOGIndexTerm: COG0176
eggNOGDescriptionValue:
  Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity)


eggNOGIndexTerm: COG0172
eggNOGDescriptionValue:
  Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity)


eggNOGIndexTerm: ENOG4111Z5Y
eggNOGDescriptionValue:
  Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity)


eggNOGIndexTerm: COG2429
eggNOGDescriptionValue:
  Catalyzes the formation of 2-amino-5-formylamino-6- ribofuranosylamino-4(3H)-pyrimidinone ribonucleotide monophosphate and inorganic phosphate from GTP. Also has an independent pyrophosphate phosphohydrolase activity (By similarity)


eggNOGIndexTerm: ENOG410YP60
eggNOGDescriptionValue:
  NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)


eggNOGIndexTerm: COG5581
eggNOGDescriptionValue:
  Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Increasing levels of c-di-GMP lead to decreased motility (By similarity)


eggNOGIndexTerm: ENOG4111D8X
eggNOGDescriptionValue:
  Required for initiation of meiotic chromosome synapsis. Involved in synaptonemal complex formation, a structure that tethers a pair of homologous chromosomes along their lengths and plays a central role in recombination and homolog segregation during meiosis


eggNOGIndexTerm: ENOG410ZN8A
eggNOGDescriptionValue:
  Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity)


eggNOGIndexTerm: ENOG410XP8Z
eggNOGDescriptionValue:
  Protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (Liprin), alpha


eggNOGIndexTerm: ENOG4111V9Y
eggNOGDescriptionValue:
  Component of the DASH complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. The DASH complex mediates the formation and maintenance of bipolar kinetochore-microtubule attachments by forming closed rings around spindle microtubules and establishing interactions with proteins from the central kinetochore


eggNOGIndexTerm: ENOG410XWDK
eggNOGDescriptionValue:
  Specific class of high-redox-potential 4Fe-4S ferredoxins. Functions in anaerobic electron transport in most purple and in some other photosynthetic bacteria and in at least one genus (Paracoccus) of halophilic, denitrifying bacteria (By similarity)


eggNOGIndexTerm: COG0013
eggNOGDescriptionValue:
  Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity)


eggNOGIndexTerm: COG0019
eggNOGDescriptionValue:
  Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity)


eggNOGIndexTerm: ENOG410YKM8
eggNOGDescriptionValue:
  May play a role in plant defense. Probably has no oxalate oxidase activity even if the active site is conserved


eggNOGIndexTerm: ENOG4112722
eggNOGDescriptionValue:
  Controls the interaction of photosystem II (PSII) cores with the light-harvesting antenna (By similarity)


eggNOGIndexTerm: ENOG4111CG7
eggNOGDescriptionValue:
  Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection. Endogenous envelope proteins may have kept, lost or modified their original function during evolution. This endogenous envelope protein has retained its original fusogenic properties


eggNOGIndexTerm: ENOG410YWXR
eggNOGDescriptionValue:
  interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)


eggNOGIndexTerm: ENOG410YT63
eggNOGDescriptionValue:
  Plant non-specific lipid-transfer proteins transfer phospholipids as well as galactolipids across membranes. May play a role in wax or cutin deposition in the cell walls of expanding epidermal cells and certain secretory tissues (By similarity)


eggNOGIndexTerm: ENOG4110738
eggNOGDescriptionValue:
  May aid fertilization by loosening the cell wall of the stigma and style, thereby facilitating penetration of the pollen tube. Acts selectively on grass cell walls, which are relatively poor in pectins and xyloglucans and rich in glucuronoarabinoxylans and (1-3),(1-4)-beta-D-glucans, when compared with cell walls of other angiosperms, including other monocots


eggNOGIndexTerm: ENOG410YCH5
eggNOGDescriptionValue:
  polygalacturonate 4-alpha-galacturonosyltransferase transferase, transferring glycosyl groups transferase, transferring hexosyl groups


eggNOGIndexTerm: ENOG410YCH7
eggNOGDescriptionValue:
  Involved in mitochondrial fission. Acts as an adapter protein required to form mitochondrial fission complexes. Formation of these complexes is required to promote constriction and fission of the mitochondrial compartment at a late step in mitochondrial division (By similarity)


eggNOGIndexTerm: COG0335
eggNOGDescriptionValue:
  This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity)


eggNOGIndexTerm: COG0332
eggNOGDescriptionValue:
  Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity)


eggNOGIndexTerm: ENOG410Y11X
eggNOGDescriptionValue:
  Involved in induction of the so-called NTR enzymes in response to nitrogen deprivation, as well as in glutamate biosynthesis. May mediate the glutamate-dependent repression of the GLT operon


eggNOGIndexTerm: ENOG410YIKI
eggNOGDescriptionValue:
  Small GTPase component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules. SAR1 controls the coat assembly in a stepwise manner. Activated SAR1-GTP binds to membranes first and recruits the SEC23 24 complex. These SEC23 24-SAR1 prebudding intermediates are then collected by the SEC13 31 complex as subunits polymerize to form coated transport vesicles. Conversion to SAR1-GDP triggers coat release and recycles COPII subunits (By similarity)


eggNOGIndexTerm: ENOG4110W9S
eggNOGDescriptionValue:
  Fucosyltransferase which adds the fucose moiety of the nod factor on its terminal reducing N-acetylglucosamine end. Uses GDP-fucose as the donor group


eggNOGIndexTerm: COG0550
eggNOGDescriptionValue:
  Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity)


eggNOGIndexTerm: COG0552
eggNOGDescriptionValue:
  Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)


eggNOGIndexTerm: COG0556
eggNOGDescriptionValue:
  damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity)


eggNOGIndexTerm: COG0557
eggNOGDescriptionValue:
  3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity)


eggNOGIndexTerm: ENOG410ZX3R
eggNOGDescriptionValue:
  Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) (By similarity)


eggNOGIndexTerm: ENOG41127JT
eggNOGDescriptionValue:
  Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites (By similarity)


eggNOGIndexTerm: COG5386
eggNOGDescriptionValue:
  Transfers its hemin to hemin-free IsdC (apo-IsdC) directly probably through the activation of the holo-IsdA-apo-IsdC complex and driven by the higher affinity of apo-IsdC for the cofactor. The reaction is reversible (By similarity). Binds transferrin, lactoferrin, heme, hemoglobin, hemin, fetuin, asialofetuin and protein A. Also binds fibronectin and chains B- beta and gamma of fibrinogen, promoting clumping of S.aureus with fibrinogen. Was also shown to adhere to plastic (By similarity). Inactivation of isdA leads to a decrease both in the amount of heme-iron associated with S.aureus cells and the amount of heme- iron that enters the staphylococcal cytoplasm. This suggests that IsdA could play a role in the removal of heme from hemoglobin. It was also demonstrated that the IsdA-mediated iron-acquisition system from transferrin could play only an ancillary role in the iron uptake whereas the siderophore-mediated iron-acquisition system from transferrin seems to play an essential or dominant role. Overexpression of isdA enhances S.aureus growth and an isdA inactivation mutant shows a growth defect when grown in liquid medium containing heme as the sole iron source which suggests that IsdA may function as a cell surface reservoir for heme. Involved in adherence of S.aureus to human desquamated nasal epithelial cells and is required for nasal colonization. Protects S.aureus against the bactericidal protease activity of apolactoferrin in vitro and confers resistance to bovine lactoferricin. Also IsdA and or IsdB promote resistance to hydrogen peroxide and killing by neutrophils (By similarity)


eggNOGIndexTerm: ENOG4111WR7
eggNOGDescriptionValue:
  E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Regulates centrosomal microtubule nucleation. Required for normal cell cycle progression from G2 to mitosis. Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle. Involved in transcriptional regulation of P21 in response to DNA damage. Required for FANCD2 targeting to sites of DNA damage. May function as a transcriptional regulator. Inhibits lipid synthesis by binding to inactive phosphorylated ACACA and preventing its dephosphorylation. Contributes to homologous recombination repair (HRR) via its direct interaction with PALB2, fine-tunes recombinational repair partly through its modulatory role in the PALB2-dependent loading of BRCA2-RAD51 repair machinery at DNA breaks. Component of the BRCA1-RBBP8 complex which regulates CHEK1 activation and controls cell cycle G2 M checkpoints on DNA damage via BRCA1-mediated ubiquitination of RBBP8 (By similarity)


eggNOGIndexTerm: ENOG4111WRP
eggNOGDescriptionValue:
  Required for the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. In the complex, it is required to stabilize and induce conformational change of the catalytic subunit


eggNOGIndexTerm: ENOG410XVU9
eggNOGDescriptionValue:
  This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity)


eggNOGIndexTerm: COG1444
eggNOGDescriptionValue:
  Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP) (By similarity)


eggNOGIndexTerm: COG1443
eggNOGDescriptionValue:
  Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity)


eggNOGIndexTerm: COG0216
eggNOGDescriptionValue:
  Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity)


eggNOGIndexTerm: COG0214
eggNOGDescriptionValue:
  Involved in the production of pyridoxal phosphate, probably by incorporating ammonia into the pyridine ring (By similarity)


eggNOGIndexTerm: COG0219
eggNOGDescriptionValue:
  Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity)


eggNOGIndexTerm: ENOG410XNQ1
eggNOGDescriptionValue:
  Plays a role in anterograde intraflagellar transport (IFT), the process by which cilia precursors are transported from the base of the cilium to the site of their incorporation at the tip


eggNOGIndexTerm: ENOG410ZFGP
eggNOGDescriptionValue:
  Central component in molecular interactions underlying sperm crawling. Forms an extensive filament system that extends from sperm villipoda, along the leading edge of the pseudopod


eggNOGIndexTerm: ENOG4111WE9
eggNOGDescriptionValue:
  Interacts with the SecY protein in vivo. May bind preferentially to an uncomplexed state of SecY, thus functioning either as a chelating agent for excess SecY in the cell or as a regulatory factor that negatively controls the translocase function (By similarity)


eggNOGIndexTerm: COG0846
eggNOGDescriptionValue:
  NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form


eggNOGIndexTerm: COG0849
eggNOGDescriptionValue:
  This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity)


eggNOGIndexTerm: ENOG4111K6Y
eggNOGDescriptionValue:
  Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors


eggNOGIndexTerm: ENOG4111DTD
eggNOGDescriptionValue:
  Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity)


eggNOGIndexTerm: ENOG4111DTJ
eggNOGDescriptionValue:
  This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport


eggNOGIndexTerm: COG3317
eggNOGDescriptionValue:
  Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity)


eggNOGIndexTerm: ENOG41121Y1
eggNOGDescriptionValue:
  chromatin protein, binds double-strand DNA without sequence specificity. Constrains negative DNA supercoils (By similarity)


eggNOGIndexTerm: ENOG410ZYA8
eggNOGDescriptionValue:
  Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity)


eggNOGIndexTerm: ENOG4111ASP
eggNOGDescriptionValue:
  Protein component of the very low density lipoprotein (VLDL) of egg-laying females. Potent lipoprotein lipase inhibitor, preventing the loss of triglycerides from VLDL on their way from the liver to the growing oocytes


eggNOGIndexTerm: ENOG410YQC6
eggNOGDescriptionValue:
  Colipase is a cofactor of pancreatic lipase. It allows the lipase to anchor itself to the lipid-water interface. Without colipase the enzyme is washed off by bile salts, which have an inhibitory effect on the lipase


eggNOGIndexTerm: ENOG410YQC4
eggNOGDescriptionValue:
  Cytokine that binds to TNFRSF1A TNFR1 and TNFRSF1B TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation


eggNOGIndexTerm: ENOG410XQPX
eggNOGDescriptionValue:
  Sulfhydryl-activated toxin that causes cytolysis by forming pores in cholesterol containing host membranes. After binding to target membranes, the protein undergoes a major conformation change, leading to its insertion in the host membrane and formation of an oligomeric pore complex. Cholesterol may be required for binding to host membranes, membrane insertion and pore formation. Can be reversibly inactivated by oxidation


eggNOGIndexTerm: ENOG41103MS
eggNOGDescriptionValue:
  Involved in regulation of actin and microtubule organization. Part of a WAVE complex that activates the Arp2 3 complex (By similarity)


eggNOGIndexTerm: COG2520
eggNOGDescriptionValue:
  Specifically methylates the N1 position of guanosine-37 in various cytoplasmic and mitochondrial tRNAs. Methylation is not dependent on the nature of the nucleoside 5' of the target nucleoside. This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding (By similarity)


eggNOGIndexTerm: ENOG4112AQ4
eggNOGDescriptionValue:
  The B protein acts as a regulator of electron flow through the soluble mmo complex, switching the enzyme from an oxidase to a hydroxylase in the presence of the substrate


eggNOGIndexTerm: ENOG4110QRM
eggNOGDescriptionValue:
  One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell (By similarity)


eggNOGIndexTerm: ENOG4111JRF
eggNOGDescriptionValue:
  Functions in complex with FlhC as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region. Activates expression of class 2 flagellar genes, including fliA, which is a flagellum-specific sigma factor that turns on the class 3 genes. Also regulates genes whose products function in a variety of physiological pathways (By similarity)


eggNOGIndexTerm: ENOG410YS30
eggNOGDescriptionValue:
  Flavoprotein monooxygenase required for N-hydroxylation of the two acylated lysine residues during mycobactin assembly, thus producing the hydroxamate groups necessary for iron sequestration. Is also able, but less efficiently, to hydroxylate L-lysine (non acylated) in vitro


eggNOGIndexTerm: ENOG410ZS1R
eggNOGDescriptionValue:
  Depolymerization of lignin. Catalyzes the C(alpha)- C(beta) cleavage of the propyl side chains of lignin


eggNOGIndexTerm: ENOG410YAUV
eggNOGDescriptionValue:
  Toxin, which has some hemolytic activity towards mammalian cells. Acts by forming a pore-like structure upon contact with mammalian cells


eggNOGIndexTerm: ENOG410YEFB
eggNOGDescriptionValue:
  responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events


eggNOGIndexTerm: ENOG410YY9R
eggNOGDescriptionValue:
  Component of the PAN1 actin cytoskeleton-regulatory complex required for the internalization of endosomes during actin-coupled endocytosis. The complex links the site of endocytosis to the cell membrane-associated actin cytoskeleton. Mediates uptake of external molecules and vacuolar degradation of plasma membrane proteins. Plays a role in the proper organization of the cell membrane-associated actin cytoskeleton and promotes its destabilization (By similarity)


eggNOGIndexTerm: COG1103
eggNOGDescriptionValue:
  Converts O-phospho-L-seryl-tRNA(Cys) (Sep-tRNA(Cys)) to L-cysteinyl-tRNA(Cys) (Cys-tRNA(Cys)) (By similarity)


eggNOGIndexTerm: COG0042
eggNOGDescriptionValue:
  Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity)


eggNOGIndexTerm: ENOG4111P3X
eggNOGDescriptionValue:
  Required for translocation of effector proteins via the type III secretion system SPI-1, which is essential for an efficient bacterial internalization. Probably acts by modulating the secretion of SipA, SipB, and SipC


eggNOGIndexTerm: ENOG410Z57H
eggNOGDescriptionValue:
  Involved in the biosynthesis of the arabinogalactan (AG) region of the mycolylarabinogalactan-peptidoglycan (mAGP) complex, an essential component the mycobacterial cell wall. Catalyzes the addition of the first key arabinofuranosyl (Araf) residue from the sugar donor beta-D-arabinofuranosyl-1-monophosphoryldecaprenol (DPA) on the C-5 of a 6-linked galactofuranosyl (Galf) of the galactan domain, thus 'priming' the galactan for further elaboration by other arabinofuranosyltransferases


eggNOGIndexTerm: COG1603
eggNOGDescriptionValue:
  Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends (By similarity)


eggNOGIndexTerm: COG1600
eggNOGDescriptionValue:
  Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity)


eggNOGIndexTerm: COG0050
eggNOGDescriptionValue:
  This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity)


eggNOGIndexTerm: COG0055
eggNOGDescriptionValue:
  Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity)


eggNOGIndexTerm: COG0054
eggNOGDescriptionValue:
  Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity)


eggNOGIndexTerm: COG0056
eggNOGDescriptionValue:
  Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity)


eggNOGIndexTerm: COG0058
eggNOGDescriptionValue:
  Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity)


eggNOGIndexTerm: ENOG410YRX9
eggNOGDescriptionValue:
  May have a structural role to stabilize the lipid body during desiccation of the seed by preventing coalescence of the oil. Probably interacts with both lipid and phospholipid moieties of lipid bodies. May also provide recognition signals for specific lipase anchorage in lipolysis during seedling growth


eggNOGIndexTerm: COG2360
eggNOGDescriptionValue:
  Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity)


eggNOGIndexTerm: ENOG410XZCF
eggNOGDescriptionValue:
  Involved in the selective degradation of mitochondria via autophagy during starvation and at post-log phase (By similarity)


eggNOGIndexTerm: ENOG410ZSE4
eggNOGDescriptionValue:
  Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome (By similarity)


eggNOGIndexTerm: ENOG410Z8K8
eggNOGDescriptionValue:
  Fimbrillin is the structural subunit of the fimbriae, that are filamentous appendages on the cell surface. Fimbriae of P.gingivalis are recognized as a major virulence factor as they mediate cell adhesion and play an important role in invasion of periodontal tissues


eggNOGIndexTerm: COG0516
eggNOGDescriptionValue:
  Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)


eggNOGIndexTerm: ENOG410ZXXA
eggNOGDescriptionValue:
  Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes


eggNOGIndexTerm: ENOG4110KM8
eggNOGDescriptionValue:
  Antagonistic role in the Wnt signaling pathway that operates in embryogenesis. When located at the cortex it has been shown to inhibit Wnt signaling during asymmetric cell division but when relocated to the nucleus it shows positive regulation. Has a role in blastomere signaling during endoderm specification. Activates lit-1-dependent kinase activity. Wrm-1 lit-1 complex promotes phosphorylation, down-regulation and subcellular relocation of pop-1. Can substitute for bar-1 indicating functional redundancy. Appears to have a role in centrosome positioning


eggNOGIndexTerm: ENOG4110M0I
eggNOGDescriptionValue:
  Complex of gpr-1 and gpr-2, in association with lin-5, activates G-protein signaling to affect mitotic spindle force. Polarity determinants (par genes) may regulate lin-5 gpr-1 gpr- 2 goa-1 locally to create the asymmetric forces that drive spindle movement


eggNOGIndexTerm: COG2227
eggNOGDescriptionValue:
  Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity)


eggNOGIndexTerm: ENOG410ZSP1
eggNOGDescriptionValue:
  CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease (By similarity)


eggNOGIndexTerm: ENOG4111XRW
eggNOGDescriptionValue:
  Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity)


eggNOGIndexTerm: ENOG4110IW2
eggNOGDescriptionValue:
  component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity)


eggNOGIndexTerm: ENOG410XPC4
eggNOGDescriptionValue:
  Guanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory type


eggNOGIndexTerm: COG1409
eggNOGDescriptionValue:
  Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity)


eggNOGIndexTerm: COG1400
eggNOGDescriptionValue:
  Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds directly to 7S RNA and mediates binding of the 54 kDa subunit of the SRP (By similarity)


eggNOGIndexTerm: COG1405
eggNOGDescriptionValue:
  Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre- initiation complex (DNA-TBP-TFIIB) (By similarity)


eggNOGIndexTerm: ENOG4111GJA
eggNOGDescriptionValue:
  Regulates secA expression by translational coupling of the secM secA operon. Translational pausing at a specific Pro residue 5 residues before the end of the protein may allow disruption of a mRNA repressor helix that normally suppresses secA translation initiation (By similarity)


eggNOGIndexTerm: COG0259
eggNOGDescriptionValue:
  Catalyzes the oxidation of either pyridoxine 5'- phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP) (By similarity)


eggNOGIndexTerm: COG0258
eggNOGDescriptionValue:
  Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double- stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA (By similarity)


eggNOGIndexTerm: COG0256
eggNOGDescriptionValue:
  This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity)


eggNOGIndexTerm: COG0253
eggNOGDescriptionValue:
  Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity)


eggNOGIndexTerm: COG4108
eggNOGDescriptionValue:
  Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity)


eggNOGIndexTerm: ENOG41105MU
eggNOGDescriptionValue:
  CONTAINS InterPro DOMAIN s Molecular chaperone, heat shock protein, Hsp40, DnaJ (InterPro IPR015609)


eggNOGIndexTerm: ENOG4111F09
eggNOGDescriptionValue:
  Required for proper folding and or the stability of a subset of proteins in the endoplasmic reticulum. Component of glycosylphosphatidylinositol-mannosyltransferase 1 which transfers the first of the 4 mannoses in the GPI-anchor precursors during GPI-anchor biosynthesis. Probably acts by stabilizing the mannosyltransferase gpi14 (By similarity)


eggNOGIndexTerm: ENOG410Y7WM
eggNOGDescriptionValue:
  Converts phosphatidylinositol 3,4,5-trisphosphate (PtdIns 3,4,5-P3) to PtdIns 3-P and prevents the transition of PtdIns 3-P to PtdIns 3,5-P2. It is one of the known effectors injected by Salmonella into the host cell and is required for invasion and for an efficient generation and maintenance of Salmonella-containing vacuole (SVC). Alteration of the phosphoinositide composition of the plasma membrane causes membrane ruffling and actin cytoskeleton rearrangements. The persistence of PtdIns 3-P diverts the SCV from the endocytic pathway resulting in enlarged vesicles, which are essential to create a favorable environment where Salmonella can replicate and avoid immune defenses of the host cell


eggNOGIndexTerm: COG0756
eggNOGDescriptionValue:
  This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity)


eggNOGIndexTerm: ENOG41122W9
eggNOGDescriptionValue:
  Transcription inhibitory protein for the torCAD operon. Also acts as an excisionase and plays an essential role in the defective prophage CPS53 excision


eggNOGIndexTerm: ENOG411190Z
eggNOGDescriptionValue:
  cell wall deposition. Required for establishment of the Casparian strip membrane domain (CSD) and the subsequent formation of Casparian strips, a cell wall modification of the root endodermis that determines an apoplastic barrier between the intraorganismal apoplasm and the extraorganismal apoplasm and prevents lateral diffusion


eggNOGIndexTerm: ENOG410XSFW
eggNOGDescriptionValue:
  Component of the ERMES MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis and may function in phospholipid exchange. mdm10 is involved in the late assembly steps of the general translocase of the mitochondrial outer membrane (TOM complex). Functions in the tom40-specific route of the assembly of outer membrane beta-barrel proteins, including the association of tom40 with the receptor tom22 and small TOM proteins. Can associate with the SAM(core) complex as well as the mdm12-mmm1 complex, both involved in late steps of the major beta-barrel assembly pathway, that is responsible for biogenesis of all outer membrane beta-barrel proteins. May act as a switch that shuttles between both complexes and channels precursor proteins into the tom40-specific pathway. Plays a role in mitochondrial morphology and in the inheritance of mitochondria (By similarity)


eggNOGIndexTerm: COG1502
eggNOGDescriptionValue:
  Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity)


eggNOGIndexTerm: COG4148
eggNOGDescriptionValue:
  Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system (By similarity)


eggNOGIndexTerm: ENOG410XUZB
eggNOGDescriptionValue:
  Component of the cytochrome b6-f complex, which mediates electron transfer between photosystem II (PSII) and photosystem I (PSI), cyclic electron flow around PSI, and state transitions (By similarity)


eggNOGIndexTerm: COG0712
eggNOGDescriptionValue:
  F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)


eggNOGIndexTerm: ENOG41118ZK
eggNOGDescriptionValue:
  Aux IAA proteins are short-lived transcriptional factors that function as repressors of early auxin response genes at low auxin concentrations (By similarity)


eggNOGIndexTerm: ENOG410Z5RE
eggNOGDescriptionValue:
  In elementary bodies (EBs, the infectious stage, which is able to survive outside the host cell) provides the structural integrity of the outer envelope through disulfide cross-links with the small cysteine-rich protein and the large cysteine-rich periplasmic protein. It has been described in publications as the Sarkosyl-insoluble COMC (Chlamydia outer membrane complex), and serves as the functional equivalent of peptidoglycan (By similarity)


eggNOGIndexTerm: ENOG4111UZW
eggNOGDescriptionValue:
  RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity)


eggNOGIndexTerm: ENOG4111582
eggNOGDescriptionValue:
  General regulatory factor (GRF) that contributes to transcriptional activation of a large number of genes, as well as to DNA replication, silencing and telomere structure. Involved in the transcription activation of a subset of ribosomal protein genes. Binds the ARS-elements found in many promoters. Binds to the sequence 5'-TCN(7)ACG-3'


eggNOGIndexTerm: ENOG410Z4QE
eggNOGDescriptionValue:
  Required for the proper initiation of DNA replication. Required for mitochondrial morphology (By similarity)


eggNOGIndexTerm: ENOG4111EF0
eggNOGDescriptionValue:
  As a component of the mitochondrial inner membrane organizing system (MINOS MitOS) complex, important for normal mitochondrial morphology (By similarity)


eggNOGIndexTerm: ENOG410XU1Y
eggNOGDescriptionValue:
  Although this protein associates with the 30S subunit of the ribosome it is not considered to be a bona fide ribosomal protein


eggNOGIndexTerm: ENOG410Y93S
eggNOGDescriptionValue:
  Catalyzes the S-methylmethionine (SMM) biosynthesis from adenosyl-L-homocysteine (AdoMet) and methionine. SMM biosynthesis (by MMT1) and degradation (by HMT-1, HMT-2 and HMT-3) constitute the SMM cycle in plants, which is probably required to achieve short term control of AdoMet level. Also able to catalyze the selenium-methylmethionine (SeMM) from AdoMet and selenium- methionine (SeMet). May play a role in phoem sulfur transport


eggNOGIndexTerm: ENOG4111QXV
eggNOGDescriptionValue:
  Component of the checkpoint clamp complex involved in the surveillance mechanism that allows the DNA repair pathways to act to restore the integrity of the DNA prior to DNA synthesis or separation of the replicated chromosomes


eggNOGIndexTerm: COG4047
eggNOGDescriptionValue:
  protects from oxidative damage by removing the major product of DNA oxidation, 8-oxoguanine (GO), from single- and double-stranded DNA substrates (By similarity)


eggNOGIndexTerm: COG0689
eggNOGDescriptionValue:
  Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity)


eggNOGIndexTerm: COG0684
eggNOGDescriptionValue:
  Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity)


eggNOGIndexTerm: ENOG4111BXR
eggNOGDescriptionValue:
  One of the two reaction center proteins of photosystem II (PSII), D2 is needed for assembly of a stable PSII complex (By similarity)


eggNOGIndexTerm: ENOG41116CR
eggNOGDescriptionValue:
  Promotes apoptosis of kidney glomerular podocytes. Podocytes are highly specialized cells essential to the ultrafiltration of blood, resulting in the extraction of urine and the retention of protein


eggNOGIndexTerm: ENOG41108B7
eggNOGDescriptionValue:
  BEST Arabidopsis thaliana protein match is harpin-induced protein-related HIN1-related harpin-responsive protein-related (TAIR AT2G27080.2)


eggNOGIndexTerm: ENOG410YGXE
eggNOGDescriptionValue:
  adds the third glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation. Transfers glucose from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide Glc(2)Man(9)GlcNAc(2)-PP-Dol


eggNOGIndexTerm: ENOG4112834
eggNOGDescriptionValue:
  Assembly factor required for Rieske Fe-S protein RIP1 incorporation into the cytochrome b-c1 (CIII) complex. Functions as a chaperone, binding to this subunit within the mitochondrial matrix and stabilizing it prior to its translocation and insertion into the late CIII dimeric intermediate within the mitochondrial inner membrane. Modulates the mitochondrial matrix zinc pool (By similarity)


eggNOGIndexTerm: ENOG410ZI42
eggNOGDescriptionValue:
  Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase (By similarity)


eggNOGIndexTerm: ENOG4111V1G
eggNOGDescriptionValue:
  component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain (By similarity)


eggNOGIndexTerm: ENOG410ZRVJ
eggNOGDescriptionValue:
  Involved in mRNA export coupled transcription activation by association with both the TREX-2 and the SAGA complexes. The transcription regulatory histone acetylation (HAT) complex SAGA is a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates in a subcomplex that specifically deubiquitinates histone H2B and is involved in the maintenance of steady-state H3 methylation levels. The TREX-2 complex functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket). TREX-2 participates in mRNA export and accurate chromatin positioning in the nucleus by tethering genes to the nuclear periphery. Has also a role in mRNP biogenesis and maintenance of genome integrity through preventing RNA-mediated genome instability (By similarity)


eggNOGIndexTerm: COG1646
eggNOGDescriptionValue:
  Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P). This reaction is the first ether-bond-formation step in the biosynthesis of archaeal membrane lipids (By similarity)


eggNOGIndexTerm: COG1644
eggNOGDescriptionValue:
  DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates


eggNOGIndexTerm: COG1648
eggNOGDescriptionValue:
  Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity)


eggNOGIndexTerm: ENOG4112BXV
eggNOGDescriptionValue:
  Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig- secreting cells Involved in lymphocyte and monocyte differentiation. It induces myeloma and plasmacytoma growth and induces nerve cells differentiation Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance


eggNOGIndexTerm: ENOG410ZZEY
eggNOGDescriptionValue:
  Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity)


eggNOGIndexTerm: COG3717
eggNOGDescriptionValue:
  Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate (By similarity)


eggNOGIndexTerm: ENOG410YXZV
eggNOGDescriptionValue:
  function. Its presence in a non-photosynthetic plant (Epifagus virginiana) and experiments in tobacco indicate that it has an essential function which is probably not related to photosynthesis


eggNOGIndexTerm: ENOG410YSWC
eggNOGDescriptionValue:
  RNA-binding nucleolar protein required for pre-rRNA processing. Involved in production of 18S rRNA and assembly of small ribosomal subunit (By similarity)


eggNOGIndexTerm: ENOG4111W7C
eggNOGDescriptionValue:
  Ligand for the GFR-alpha-3-RET receptor complex but can also activate the GFR-alpha-1-RET receptor complex. Supports the survival of sensory and sympathetic peripheral neurons in culture and also supports the survival of dopaminergic neurons of the ventral mid-brain


eggNOGIndexTerm: ENOG4110B51
eggNOGDescriptionValue:
  RNA-binding protein involved in post-transcriptional regulation through transcript degradation. May be involved in vacuolar protein transport (By similarity)


eggNOGIndexTerm: ENOG4111IPI
eggNOGDescriptionValue:
  Component of the transcription regulatory histone acetylation (HAT) complex SAGA, a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates in a subcomplex that specifically deubiquitinates histone H2B. The SAGA complex is recruited to specific gene promoters by activators, where it is required for transcription


eggNOGIndexTerm: COG1746
eggNOGDescriptionValue:
  Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate (By similarity)


eggNOGIndexTerm: COG1747
eggNOGDescriptionValue:
  Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity)


eggNOGIndexTerm: ENOG410YICA
eggNOGDescriptionValue:
  High-conductance voltage-dependent solute channel with a slight selectivity for cations transporting triosephosphates, dicarboxylic acids, ATP, inorganic phosphate (Pi), sugars, and positively or negatively charged amino acids (By similarity)


eggNOGIndexTerm: ENOG4111YRI
eggNOGDescriptionValue:
  Catalyzes the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction relaxation and a potent inhibitor of platelet aggregation. Involved in a variety of CNS functions, such as sedation, NREM sleep and PGE2-induced allodynia, and may have an anti-apoptotic role in oligodendrocytes. Binds small non-substrate lipophilic molecules, including biliverdin, bilirubin, retinal, retinoic acid and thyroid hormone, and may act as a scavenger for harmful hydrophopic molecules and as a secretory retinoid and thyroid hormone transporter. Possibly involved in development and maintenance of the blood-brain, blood-retina, blood-aqueous humor and blood-testis barrier. It is likely to play important roles in both maturation and maintenance of the central nervous system and male reproductive system


eggNOGIndexTerm: ENOG410ZPI4
eggNOGDescriptionValue:
  Phosphodiesterase responsible for the U6 snRNA 3' end processing. Acts as an exoribonuclease (RNase) responsible for trimming the poly(U) tract of the last nucleotides in the pre-U6 snRNA molecule, leading to the formation of mature U6 snRNA (By similarity)


eggNOGIndexTerm: ENOG410XW18
eggNOGDescriptionValue:
  Involved in the binding and or turnover of quinones at the Q(B) site of Photosystem II (By similarity)


eggNOGIndexTerm: COG3076
eggNOGDescriptionValue:
  Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome (By similarity)


eggNOGIndexTerm: COG3074
eggNOGDescriptionValue:
  Non-essential, abundant cell division factor that is required for proper Z-ring formation. It is recruited early to the divisome by direct interaction with FtsZ, stimulating Z-ring assembly and thereby promoting cell division earlier in the cell cycle. Its recruitment to the Z-ring requires functional FtsA or ZipA (By similarity)


eggNOGIndexTerm: COG3078
eggNOGDescriptionValue:
  A GTPase-activating protein (GAP) that modifies Der EngA GTPase function. May play a role in ribosome biogenesis (By similarity)


eggNOGIndexTerm: COG2269
eggNOGDescriptionValue:
  With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P (By similarity)


eggNOGIndexTerm: ENOG4111B0I
eggNOGDescriptionValue:
  Translation factor specific for subunit 6 of the mitochondrial ATPase. Required for assembly of the CF(0) component of the ATPase (By similarity)


eggNOGIndexTerm: ENOG410XRCI
eggNOGDescriptionValue:
  His Glu Gln Arg opine family ABC transporter, periplasmic His Glu Gln Arg opine family-binding protein


eggNOGIndexTerm: ENOG410ZCK9
eggNOGDescriptionValue:
  Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown black pigment) and thus increasing synthesis of pheomelanin (yellow red pigment)


eggNOGIndexTerm: COG0293
eggNOGDescriptionValue:
  Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity)


eggNOGIndexTerm: COG0292
eggNOGDescriptionValue:
  Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity)


eggNOGIndexTerm: COG0290
eggNOGDescriptionValue:
  IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity)


eggNOGIndexTerm: COG0296
eggNOGDescriptionValue:
  Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity)


eggNOGIndexTerm: ENOG411249S
eggNOGDescriptionValue:
  Antenna complexes are light-harvesting systems, which transfer the excitation energy to the reaction centers (By similarity)


eggNOGIndexTerm: ENOG410XSYC
eggNOGDescriptionValue:
  Histone methyltransferase that specifically methylates histone H3 to form H3K79me. This methylation is required for telomere silencing and for the pachytene checkpoint during the meiotic cell cycle by allowing the recruitment of RAD9 to double strand breaks. Nucleosomes are preferred as substrate compared to free histones (By similarity)


eggNOGIndexTerm: COG2092
eggNOGDescriptionValue:
  Promotes the exchange of GDP for GTP in EF-1-alpha GDP, thus allowing the regeneration of EF-1-alpha GTP that could then be used to form the ternary complex EF-1-alpha GTP AAtRNA (By similarity)


eggNOGIndexTerm: COG2098
eggNOGDescriptionValue:
  Catalyzes the conversion of 7,8-dihydroneopterin (H2Neo) to 6-hydroxymethyl-7,8-dihydropterin (6-HMD) (By similarity)


eggNOGIndexTerm: COG1220
eggNOGDescriptionValue:
  this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity)


eggNOGIndexTerm: COG0430
eggNOGDescriptionValue:
  Catalyzes the conversion of 3'-phosphate to a 2',3'- cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps (A) adenylation of the enzyme by ATP


eggNOGIndexTerm: COG3117
eggNOGDescriptionValue:
  Required for the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane (By similarity)


eggNOGIndexTerm: ENOG411113P
eggNOGDescriptionValue:
  Activates transcription of bacteriorhodopsin (bop) and phytoene synthase (crtB1). May interact with DNA or RNA via the zinc finger motif (By similarity)


eggNOGIndexTerm: ENOG41128NV
eggNOGDescriptionValue:
  Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity)


eggNOGIndexTerm: ENOG410XQXX
eggNOGDescriptionValue:
  Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity)


eggNOGIndexTerm: ENOG410XQX1
eggNOGDescriptionValue:
  Catalyzes the two-electron reduction of biliverdin IX- alpha at the C15 methine bridge (By similarity)


eggNOGIndexTerm: ENOG410YNT9
eggNOGDescriptionValue:
  GLC7 phosphatase-regulatory protein involved in GLC7 subcellular redistribution and chromosome segregation


eggNOGIndexTerm: ENOG410ZFTR
eggNOGDescriptionValue:
  Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly (By similarity)


eggNOGIndexTerm: ENOG410XVGA
eggNOGDescriptionValue:
  Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity)


eggNOGIndexTerm: ENOG410Y3PV
eggNOGDescriptionValue:
  CAP-1 and CAP-2, but not CAP-3 are ligands for the Capa receptor. CAP-1 and CAP-2 are probably components of the signal transduction pathway that leads to Malpighian tubule fluid secretion via the second messenger nitric oxide


eggNOGIndexTerm: COG4105
eggNOGDescriptionValue:
  Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane


eggNOGIndexTerm: COG1364
eggNOGDescriptionValue:
  Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate (By similarity)


eggNOGIndexTerm: ENOG41124JV
eggNOGDescriptionValue:
  Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone


eggNOGIndexTerm: ENOG410Y9ZI
eggNOGDescriptionValue:
  Represses expression of the flagellar master operon flhDC, and consequently prevents flagellum biosynthesis and motility. Acts by binding to the regulatory region of the flhDC operon


eggNOGIndexTerm: ENOG410ZQTM
eggNOGDescriptionValue:
  Translocates 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the inner membrane (By similarity)


eggNOGIndexTerm: COG5108
eggNOGDescriptionValue:
  DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)


eggNOGIndexTerm: COG0682
eggNOGDescriptionValue:
  Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity)


eggNOGIndexTerm: ENOG4111KT5
eggNOGDescriptionValue:
  Phosphodiesterase responsible for the U6 snRNA 3' end processing. Acts as an exoribonuclease (RNase) responsible for trimming the poly(U) tract of the last nucleotides in the pre-U6 snRNA molecule, leading to the formation of mature U6 snRNA


eggNOGIndexTerm: ENOG410Z13C
eggNOGDescriptionValue:
  Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum (By similarity)


eggNOGIndexTerm: ENOG4111568
eggNOGDescriptionValue:
  Aux IAA proteins are short-lived transcriptional factors that function as repressors of early auxin response genes at low auxin concentrations. Repression is thought to result from the interaction with auxin response factors (ARFs), proteins that bind to the auxin-responsive promoter element (AuxRE). Formation of heterodimers with ARF proteins may alter their ability to modulate early auxin response genes expression


eggNOGIndexTerm: ENOG411156Q
eggNOGDescriptionValue:
  Essential for respiratory growth and required for mitochondrial protein synthesis. Required for vacuolar acidification (By similarity)


eggNOGIndexTerm: COG2834
eggNOGDescriptionValue:
  Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) (By similarity)


eggNOGIndexTerm: COG1968
eggNOGDescriptionValue:
  Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity)


eggNOGIndexTerm: COG1962
eggNOGDescriptionValue:
  Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step. MtrH catalyzes the transfer of the methyl group from methyl-tetrahydromethanopterin to the corrinoid prosthetic group of MtrA


eggNOGIndexTerm: ENOG4111ZAM
eggNOGDescriptionValue:
  Transcription factor involved in the regulation of gene expression in response to extracellular amino acid levels. Synthesized as latent cytoplasmic precursor, which, upon a signal initiated by the plasma membrane SPS (SSY1-PTR3-SSY5) amino acid sensor system, becomes proteolytically activated and relocates to the nucleus, where it induces the expression of SPS-sensor- regulated genes, including the amino-acid permeases


eggNOGIndexTerm: ENOG41119N5
eggNOGDescriptionValue:
  Removal of H(2)O(2), oxidation of toxic reductants, biosynthesis and degradation of lignin, suberization, auxin catabolism, response to environmental stresses such as wounding, pathogen attack and oxidative stress. These functions might be dependent on each isozyme isoform in each plant tissue


eggNOGIndexTerm: ENOG41115CE
eggNOGDescriptionValue:
  Essential for mitochondrial protein synthesis and required for the maturation of small ribosomal subunits


eggNOGIndexTerm: ENOG410XYA8
eggNOGDescriptionValue:
  Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles


eggNOGIndexTerm: COG0182
eggNOGDescriptionValue:
  Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity)


eggNOGIndexTerm: COG0181
eggNOGDescriptionValue:
  Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity)


eggNOGIndexTerm: COG0187
eggNOGDescriptionValue:
  DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)


eggNOGIndexTerm: COG0184
eggNOGDescriptionValue:
  Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity)


eggNOGIndexTerm: COG0189
eggNOGDescriptionValue:
  Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity)


eggNOGIndexTerm: ENOG4111IIK
eggNOGDescriptionValue:
  Low-potential cytochrome c that plays a role in the oxygen-evolving complex of photosystem II (By similarity)


eggNOGIndexTerm: ENOG41113TM
eggNOGDescriptionValue:
  Heterochronic protein which controls the choice of stage specific cell fates. Involved in the temporal progression of vulval fate patterning, possibly by inhibiting lin-12. Acts as a transcription factor involved in the stage-specific repression of insulin insulin-like growth factor gene ins-33


eggNOGIndexTerm: ENOG410ZC96
eggNOGDescriptionValue:
  One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell


eggNOGIndexTerm: COG5241
eggNOGDescriptionValue:
  Excision repair cross-complementing rodent repair deficiency, complementation group 1 (Includes overlapping antisense sequence)


eggNOGIndexTerm: COG5240
eggNOGDescriptionValue:
  The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non- clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins (By similarity)


eggNOGIndexTerm: COG0088
eggNOGDescriptionValue:
  One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity)


eggNOGIndexTerm: COG0089
eggNOGDescriptionValue:
  One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity)


eggNOGIndexTerm: COG0083
eggNOGDescriptionValue:
  Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity)


eggNOGIndexTerm: COG0081
eggNOGDescriptionValue:
  Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity)


eggNOGIndexTerm: COG0087
eggNOGDescriptionValue:
  One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity)


eggNOGIndexTerm: ENOG410ZHPP
eggNOGDescriptionValue:
  The oral intake in the colostrum and the milk could have a role in the modulation of the immune responses in neonates. May also have a role in the central control of body fluid homeostasis by influencing AVP release and drinking behavior


eggNOGIndexTerm: ENOG410YVRQ
eggNOGDescriptionValue:
  positive regulation of transcription from RNA polymerase II promoter in response to iron ion starvation


eggNOGIndexTerm: ENOG411257U
eggNOGDescriptionValue:
  Gas vesicles are small, hollow, gas filled protein structures that are found in several microbial planktonic microorganisms. They allow the positioning of the organism at the favorable depth for growth


eggNOGIndexTerm: ENOG41123BX
eggNOGDescriptionValue:
  Probably a connector protein for RcsB C regulation of biofilm formation, providing additional signal input into the two- component signaling pathway. Partially antagonizes the activities of YmgA and AriR, proteins that, via the Rcs phosphorelay, promote the synthesis of colanic acid, an exopolysaccharide and matrix component


eggNOGIndexTerm: COG2171
eggNOGDescriptionValue:
  Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2- amino-6-oxopimelate using succinyl-CoA (By similarity)


eggNOGIndexTerm: COG2176
eggNOGDescriptionValue:
  Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity)


eggNOGIndexTerm: COG0593
eggNOGDescriptionValue:
  it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity)


eggNOGIndexTerm: ENOG410XW5A
eggNOGDescriptionValue:
  May cause loosening and extension of plant cell walls by disrupting non-covalent bonding between cellulose microfibrils and matrix glucans. No enzymatic activity has been found. May be required for rapid internodal elongation in deepwater rice during submergence (By similarity)


eggNOGIndexTerm: ENOG41127H3
eggNOGDescriptionValue:
  Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Activated D-alanyl-Dcp donates its D-alanyl substituent to membrane-associated LTA (By similarity)


eggNOGIndexTerm: ENOG41128WT
eggNOGDescriptionValue:
  Non-catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5' and 3' splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body


eggNOGIndexTerm: ENOG410XPKG
eggNOGDescriptionValue:
  lysosomal cobalamin transporter. Required to export cobalamin from lysosomes allowing its conversion to cofactors (By similarity)


eggNOGIndexTerm: ENOG4111J36
eggNOGDescriptionValue:
  May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity)


eggNOGIndexTerm: ENOG4111J3J
eggNOGDescriptionValue:
  Has endoglucanase activity on substrates containing beta-1,4 glycosidic bonds, like in carboxymethylcellulose (CMC), hydroxyethylcellulose (HEC) and beta-glucan. Involved in the degradation of complex natural cellulosic substrates


eggNOGIndexTerm: COG3288
eggNOGDescriptionValue:
  The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity)


eggNOGIndexTerm: ENOG410YEPY
eggNOGDescriptionValue:
  Catalyzes the oxidation of Mn(2 ) to Mn(3 ). The latter, acting as a diffusible redox mediator, is capable of oxidizing a variety of lignin compounds


eggNOGIndexTerm: ENOG4111WYE
eggNOGDescriptionValue:
  Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a ATP6 static relative to the rotary elements


eggNOGIndexTerm: COG3130
eggNOGDescriptionValue:
  During stationary phase, converts 70S ribosomes to an inactive dimeric form (100S ribosomes) (By similarity)


eggNOGIndexTerm: ENOG411290D
eggNOGDescriptionValue:
  Acts as an inhibitor of cap-dependent translation. Competes with eIF4G1 and EAP1 for binding to eIF4E and interferes with the formation of the eIF4F complex, inhibiting translation and stabilizing mRNA (By similarity)


eggNOGIndexTerm: ENOG410YCVF
eggNOGDescriptionValue:
  - Bric-a-Brac, Tramtrack, Broad Complex BTB domain with TAZ zinc finger and Calmodulin-binding domains, expressed


eggNOGIndexTerm: ENOG4111AWA
eggNOGDescriptionValue:
  Promotes activation of caspases and apoptosis. Promotes mitochondrial membrane changes and efflux of apoptogenic proteins from the mitochondria. Contributes to p53 TP53-dependent apoptosis after radiation exposure. Promotes proteasomal degradation of MCL1. Competes with


eggNOGIndexTerm: ENOG4111AWM
eggNOGDescriptionValue:
  Lactoglobulin is the primary component of whey, it binds retinol and is probably involved in the transport of that molecule


eggNOGIndexTerm: COG1274
eggNOGDescriptionValue:
  Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle (By similarity)


eggNOGIndexTerm: ENOG41126MK
eggNOGDescriptionValue:
  An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity)


eggNOGIndexTerm: COG0465
eggNOGDescriptionValue:
  Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)


eggNOGIndexTerm: ENOG411229V
eggNOGDescriptionValue:
  transcription factor with a role in the retinal determination (RD) network. Regulates ato expression and is required for normal R8 induction and differentiation. Danr appears to repress Dan expression, but Dan is required for Danr expression anterior to the morphogenetic furrow (MF). Dan and Danr lie downstream of so and require dac function for highest levels of expression. Contributes to differentiation of antenna-specific characteristics


eggNOGIndexTerm: COG1589
eggNOGDescriptionValue:
  Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity)


eggNOGIndexTerm: COG1581
eggNOGDescriptionValue:
  Binds double-stranded DNA tightly but without sequence specificity. It is distributed uniformly and abundantly on the chromosome, suggesting a role in chromatin architecture. However, it does not significantly compact DNA. Binds rRNA and mRNA in vivo. May play a role in maintaining the structural and functional stability of RNA, and, perhaps, ribosomes (By similarity)


eggNOGIndexTerm: COG1586
eggNOGDescriptionValue:
  Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity)


eggNOGIndexTerm: COG3381
eggNOGDescriptionValue:
  Involved in the biogenesis of TorA. Acts on TorA before the insertion of the molybdenum cofactor and, as a result, probably favors a conformation of the apoenzyme that is competent for acquiring the cofactor (By similarity)


eggNOGIndexTerm: ENOG4111ABP
eggNOGDescriptionValue:
  Stationary phase-essential protein not required for growth on nonfermentable carbon sources (By similarity)


eggNOGIndexTerm: COG1327
eggNOGDescriptionValue:
  Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity)


eggNOGIndexTerm: COG0799
eggNOGDescriptionValue:
  Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity)


eggNOGIndexTerm: ENOG4111C2W
eggNOGDescriptionValue:
  Involved in cation homeostasis and in the regulation of the cation stress signaling cascades (By similarity)


eggNOGIndexTerm: ENOG41118MH
eggNOGDescriptionValue:
  Essential for respiratory growth and required for maintenance of mtDNA. Required for cell survival in the absence of prohibitins (By similarity)


eggNOGIndexTerm: COG0648
eggNOGDescriptionValue:
  Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity)


eggNOGIndexTerm: ENOG410XX3J
eggNOGDescriptionValue:
  Component of the telomerase complex involved in telomere replication. Stimulates RNA DNA heteroduplex unwinding which favors the telomere replication by the telomerase


eggNOGIndexTerm: ENOG4111ND7
eggNOGDescriptionValue:
  Ubiquitin-like protein involved in cytoplasm to vacuole transport (Cvt), autophagy vesicles formation, mitophagy, and nucleophagy. Conjugation with atg5 through an ubiquitin-like conjugating system involving also atg7 as an E1-like activating enzyme and atg10 as an E2-like conjugating enzyme, is essential for its function. The atg12-atg5 conjugate functions as an E3-like enzyme which is required for lipidation of atg8 and atg8 association to the vesicle membranes


eggNOGIndexTerm: ENOG410ZJ40
eggNOGDescriptionValue:
  The circumsporozoite protein is the immunodominant surface antigen on the sporozoite (the infective stage of the malaria parasite that is transmitted from the mosquito to the vertebrate host)


eggNOGIndexTerm: ENOG410Y56G
eggNOGDescriptionValue:
  Component of the IMD signaling pathway and is required for the host defense against Gram-negative bacteria. BG4 interacts with Dredd, it promotes cleavage of Dredd and is necessary and sufficient for enhancing Dredd-induced apoptosis


eggNOGIndexTerm: ENOG410XVTY
eggNOGDescriptionValue:
  Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity)


eggNOGIndexTerm: ENOG4111R51
eggNOGDescriptionValue:
  Calcium-binding peroxygenase involved in the degradation of storage lipid in oil bodies. May be involved in the interaction between oil bodies and vacuoles during seed germination and in the oxylipin signaling pathways and plant defense responses. Can catalyze sulfoxidation of thiobenzamide, hydroxylation of aniline


eggNOGIndexTerm: ENOG410XRGE
eggNOGDescriptionValue:
  Component of an E3 ubiquitin ligase complex that plays a central role in blue light-dependent circadian cycles. Acts as a blue light photoreceptor, due to the presence of FMN, that mediates light-regulated protein degradation of critical clock components by targeting them to the proteasome complex


eggNOGIndexTerm: COG2870
eggNOGDescriptionValue:
  Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity)


eggNOGIndexTerm: COG1923
eggNOGDescriptionValue:
  RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity)


eggNOGIndexTerm: COG5450
eggNOGDescriptionValue:
  Antitoxin component of a toxin-antitoxin (TA) module. Upon expression in M.smegmatis neutralizes the effect of cognate toxin


eggNOGIndexTerm: ENOG4111UIZ
eggNOGDescriptionValue:
  Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity)


eggNOGIndexTerm: ENOG41119RI
eggNOGDescriptionValue:
  Functions as an inhibitory receptor that plays a constitutive negative regulatory role on cytolytic function of natural killer (NK) cells, B-cells and T-cells. Activation by Tyr phosphorylation results in recruitment and activation of the phosphatases PTPN6 and PTPN11. It also reduces the increase of intracellular calcium evoked by B-cell receptor ligation. May also play its inhibitory role independently of SH2-containing phosphatases. Modulates cytokine production in CD4 T-cells, down- regulating IL2 and IFNG production while inducing secretion of transforming growth factor beta. Down-regulates also IgG and IgE production in B-cells as well as IL8, IL10 and TNF secretion. Inhibits proliferation and induces apoptosis in myeloid leukemia cell lines as well as prevents nuclear translocation of NF-kappa-B p65 subunit RELA and phosphorylation of I-kappa-B alpha CHUK in these cells. Inhibits the differentiation of peripheral blood precursors towards dendritic cells


eggNOGIndexTerm: ENOG41127UW
eggNOGDescriptionValue:
  Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell (By similarity)


eggNOGIndexTerm: ENOG410Z1BP
eggNOGDescriptionValue:
  IL-8 is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes. It is also involved in neutrophil activation. It is released from several cell types in response to an inflammatory stimulus


eggNOGIndexTerm: ENOG4110MJE
eggNOGDescriptionValue:
  Component of RNA polymerase I core factor complex that acts as a GTF2B TFIIB-like factor and plays a key role in multiple steps during trancription initiation such as preinitiation complex (PIC) assembly and postpolymerase recruitment events in polymerase I (Pol I) transcription. Binds rDNA promoters and plays a role in Pol I recruitment (By similarity)


eggNOGIndexTerm: COG0838
eggNOGDescriptionValue:
  NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain


eggNOGIndexTerm: ENOG4111IMV
eggNOGDescriptionValue:
  P2X receptors are ATP-gated ion channels that play a role in intracellular calcium signaling. Not required for the purinergic response to extracellular nucleotides


eggNOGIndexTerm: ENOG4111P8N
eggNOGDescriptionValue:
  Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity)


eggNOGIndexTerm: ENOG410Y1T2
eggNOGDescriptionValue:
  Probably a connector protein for RcsB C regulation of biofilm and acid-resistance, providing additional signal input into the two-component signaling pathway. May serve to stimulate biofilm maturation, via the Rcs phosphorelay. Regulates expression of genes involved in acid-resistance and biofilm formation, including the RcsB C two-component system. May be a non-specific DNA-binding protein that binds genes and or intergenic regions via a geometric recognition. Also confers resistance to H(2)O(2). Overexpression at 28 and 16 degrees Celsius increases the production of colanic acid, an exopolysaccharide and matrix component, and reduces adhesive curli fimbriae expression. Both of these effects require RcsB


eggNOGIndexTerm: ENOG41121EV
eggNOGDescriptionValue:
  Transcription factor involved in regulation of RNA polymerase II-dependent transcription. Also involved in regulation of mitochondrial DNA recombination, maintenance and repair, and generation of homoplasmic cells


eggNOGIndexTerm: COG5404
eggNOGDescriptionValue:
  Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1 1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division (By similarity)


eggNOGIndexTerm: ENOG4111XXR
eggNOGDescriptionValue:
  Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity)


eggNOGIndexTerm: ENOG410YP23
eggNOGDescriptionValue:
  Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone


eggNOGIndexTerm: ENOG4110PKR
eggNOGDescriptionValue:
  Pectinolytic enzyme consist of four classes of enzymes pectin lyase, polygalacturonase, pectin methylesterase and rhamnogalacturonase. Among pectinolytic enzymes, pectin lyase is the most important in depolymerization of pectin, since it cleaves internal glycosidic bonds of highly methylated pectins. Favors pectate, the anion, over pectin, the methyl ester (By similarity)


eggNOGIndexTerm: ENOG4111Q8H
eggNOGDescriptionValue:
  Specifically acetylates 'Lys-40' in alpha-tubulin on the lumenal side of microtubules. May affect microtubule stability and regulate microtubule dynamics


eggNOGIndexTerm: ENOG410XZH4
eggNOGDescriptionValue:
  Promotes the disassembly of phosphorylated vimentin intermediate filaments (IF) during mitosis and may play a role in the trafficking and distribution of IF proteins and other cellular factors to daughter cells during progenitor cell division


eggNOGIndexTerm: ENOG4111SI2
eggNOGDescriptionValue:
  Glucose-responsive transcription factor that regulates expression of several glucose transporter (HXT) genes in response to glucose. In the absence of glucose, it functions as a transcriptional repressor, whereas high concentrations of glucose cause it to function as a transcriptional activator. In cells growing on low levels of glucose, has a neutral role, neither repressing nor activating transcription


eggNOGIndexTerm: ENOG410ZZF3
eggNOGDescriptionValue:
  Involved in rRNA-processing at A0, A1 and A2 sites and regulates negatively telomerase (By similarity)


eggNOGIndexTerm: ENOG411074H
eggNOGDescriptionValue:
  Transcriptional activator that binds specifically to the DNA sequence 5'- AG CCGAC-3'. Binding to the C-repeat DRE element mediates high salinity- and dehydration-inducible transcription. Confers resistance to high salt, cold and drought stress (By similarity)


eggNOGIndexTerm: ENOG411074Q
eggNOGDescriptionValue:
  Transcriptional activator that binds specifically to the DNA sequence 5'- AG CCGAC-3'. Binding to the C-repeat DRE element mediates high salinity- and dehydration-inducible transcription (By similarity)


eggNOGIndexTerm: COG0349
eggNOGDescriptionValue:
  Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity)


eggNOGIndexTerm: COG0341
eggNOGDescriptionValue:
  Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity)


eggNOGIndexTerm: COG0343
eggNOGDescriptionValue:
  Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity)


eggNOGIndexTerm: ENOG4111SZ9
eggNOGDescriptionValue:
  Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking


eggNOGIndexTerm: ENOG411233T
eggNOGDescriptionValue:
  Has kinase activity and phosphorylates inositol- 1,3,4,5,6-pentakisphosphate (Ins(1,3,4,5,6)P5) to produce 1,2,3,4,5,6-hexakisphosphate (InsP6), also known as phytate


eggNOGIndexTerm: ENOG410XPW5
eggNOGDescriptionValue:
  Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome (By similarity)


eggNOGIndexTerm: ENOG410Z5KE
eggNOGDescriptionValue:
  Transcription factor that regulates pseudohyphal differentiation, invasive growth, floculation, adhesion and starch metabolism in response to nutrient availability (By similarity)


eggNOGIndexTerm: ENOG410YB82
eggNOGDescriptionValue:
  Cell surface adhesion protein. Mediates the adherence of lymphocytes to endothelial cells of high endothelial venules in peripheral lymph nodes. Promotes initial tethering and rolling of leukocytes in endothelia (By similarity)


eggNOGIndexTerm: ENOG4110SVE
eggNOGDescriptionValue:
  Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis. They compact sperm DNA into a highly condensed, stable and inactive complex


eggNOGIndexTerm: COG0049
eggNOGDescriptionValue:
  One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity)


eggNOGIndexTerm: COG2017
eggNOGDescriptionValue:
  converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity)


eggNOGIndexTerm: ENOG410ZZSA
eggNOGDescriptionValue:
  Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln) (By similarity)


eggNOGIndexTerm: ENOG41107YY
eggNOGDescriptionValue:
  transcription factor that plays an important role in building the laminar joint between leaf blade and leaf sheath boundary, thereby controlling ligule and auricle development (By similarity)


eggNOGIndexTerm: ENOG410YCRV
eggNOGDescriptionValue:
  loosening and extension of plant cell walls by disrupting non-covalent bonding between cellulose microfibrils and matrix glucans. No enzymatic activity has been found


eggNOGIndexTerm: COG0775
eggNOGDescriptionValue:
  Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity)


eggNOGIndexTerm: ENOG4111C8E
eggNOGDescriptionValue:
  Forms a chaperone-bound H2A.Z-H2B complex that acts as a source for SWR1 complex-dependent H2A to H2A.Z histone replacement in chromatin (By similarity)


eggNOGIndexTerm: ENOG4111GQD
eggNOGDescriptionValue:
  In elementary bodies (EBs, the infectious stage, which is able to survive outside the host cell) provides the structural integrity of the outer envelope through disulfide cross-links with the small cysteine-rich protein and the major outer membrane porin. It has been described in publications as the Sarkosyl- insoluble COMC (Chlamydia outer membrane complex), and serves as the functional equivalent of peptidoglycan


eggNOGIndexTerm: ENOG41122QH
eggNOGDescriptionValue:
  Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across the thylakoid membrane. Involved in delta pH-dependent protein transport required for chloroplast development, especially thylakoid membrane formation. TATC and TATB mediate precursor recognition, whereas TATA facilitates translocation


eggNOGIndexTerm: COG1826
eggNOGDescriptionValue:
  Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity)


eggNOGIndexTerm: COG1825
eggNOGDescriptionValue:
  This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity)


eggNOGIndexTerm: COG5623
eggNOGDescriptionValue:
  Required for endonucleolytic cleavage during polyadenylation-dependent pre-mRNA 3'-end formation (By similarity)


eggNOGIndexTerm: ENOG4111AFZ
eggNOGDescriptionValue:
  CONTAINS InterPro DOMAIN s TFIIS N-terminal (InterPro IPR017923), Transcription elongation factor, TFIIS CRSP70, N-terminal, sub-type (InterPro IPR003617)


eggNOGIndexTerm: ENOG4112BFE
eggNOGDescriptionValue:
  of 176 from GenPept emb CAD02952.1 (AL627277) exported protein Salmonella enterica subsp. enterica serovar Typhi


eggNOGIndexTerm: ENOG4111JB9
eggNOGDescriptionValue:
  Together with AlgI and AlgF, forms an inner membrane complex which probably interacts with the alginate polymerization- transport complex and adds acetyl groups at the O-2 and O-3 positions of polymannuronic acid. Acetylation of alginate


eggNOGIndexTerm: ENOG4111JBG
eggNOGDescriptionValue:
  Component of the nascent polypeptide-associated complex (NAC), a dynamic component of the ribosomal exit tunnel, protecting the emerging polypeptides from interaction with other cytoplasmic proteins to ensure appropriate nascent protein targeting (By similarity). The NAC complex also promotes mitochondrial protein import by enhancing productive ribosome interactions with the outer mitochondrial membrane and blocks the inappropriate interaction of ribosomes translating non-secretory nascent polypeptides with translocation sites in the membrane of the endoplasmic reticulum (By similarity). EGD1 may act as a transcription factor that exert a negative effect on the expression of several genes that are transcribed by RNA polymerase II (By similarity)


eggNOGIndexTerm: COG4447
eggNOGDescriptionValue:
  The ortholog in A.thaliana is involved in photosystem II (PSII) assembly, but knockout of the corresponding gene in Synechoccus PCC 7002 has no effect on PSII activity


eggNOGIndexTerm: COG1135
eggNOGDescriptionValue:
  Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity)


eggNOGIndexTerm: ENOG410YZBM
eggNOGDescriptionValue:
  Potent plasminogen activator that converts plasminogen into plasmin. It forms a 1 1 complex with plasmin, which in turn activates other plasminogen molecules


eggNOGIndexTerm: COG0605
eggNOGDescriptionValue:
  Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity)


eggNOGIndexTerm: COG0602
eggNOGDescriptionValue:
  Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity)


eggNOGIndexTerm: COG0603
eggNOGDescriptionValue:
  Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity)


eggNOGIndexTerm: ENOG410Y5VM
eggNOGDescriptionValue:
  Residues 2 to 179 of 179 are 100.00 pct identical to residues 1 to 178 of 178 from SwissProt.40 sp P42190 PAPK_ECOLI PROTEIN PAPK PRECURSOR


eggNOGIndexTerm: ENOG410XVPP
eggNOGDescriptionValue:
  This b-type cytochrome is tightly associated with the reaction center of photosystem II and possibly is part of the water-oxidation complex (By similarity)


eggNOGIndexTerm: ENOG410ZBXC
eggNOGDescriptionValue:
  Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group (By similarity)


eggNOGIndexTerm: ENOG4111TQA
eggNOGDescriptionValue:
  Binds to cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity)


eggNOGIndexTerm: ENOG4111R9K
eggNOGDescriptionValue:
  Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ


eggNOGIndexTerm: ENOG4111R98
eggNOGDescriptionValue:
  Toxic component of a toxin-antitoxin (TA) module. Overexpression leads to growth arrest after 5 hours, with initial elongation of cells, followed by swelling. The toxic effects are abrogated by coexpression with antitoxin CptB. Interacts with cytoskeletal proteins FtsZ and MreB


eggNOGIndexTerm: ENOG410XRKC
eggNOGDescriptionValue:
  (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1) S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin


eggNOGIndexTerm: ENOG41124YI
eggNOGDescriptionValue:
  Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space. The


eggNOGIndexTerm: COG1060
eggNOGDescriptionValue:
  Catalyzes the radical-mediated transfer of the hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino- 6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) (By similarity)


eggNOGIndexTerm: ENOG410XXDN
eggNOGDescriptionValue:
  Residues 9 to 151 of 151 are 98.60 pct identical to residues 1 to 143 of 143 from GenPept.129 gb AAK00476.1 (AF200692)


eggNOGIndexTerm: ENOG4111UUS
eggNOGDescriptionValue:
  Catalyzes the transfer of an acetyl group from acetyl- CoA to the 6'-amino group of aminoglycoside molecules conferring resistance to antibiotics containing the purpurosamine ring (By similarity)


eggNOGIndexTerm: ENOG41127YR
eggNOGDescriptionValue:
  Xylosylphosphotransferase that is specific for UDP- xylose as a donor and mannose as an acceptor to form a xylose- alpha-1-phosphate-6-mannose linkage. Functions in the O- glycosylation of proteins en route through the secretory pathway (By similarity)


eggNOGIndexTerm: ENOG4111TJT
eggNOGDescriptionValue:
  Metalloprotease, specifically cleaves on the N-terminal side of aspartyl, glutamyl and cysteic acid residues (By similarity)


eggNOGIndexTerm: COG0108
eggNOGDescriptionValue:
  Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity)


eggNOGIndexTerm: COG0102
eggNOGDescriptionValue:
  This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity)


eggNOGIndexTerm: COG0101
eggNOGDescriptionValue:
  Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity)


eggNOGIndexTerm: COG0107
eggNOGDescriptionValue:
  IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity)


eggNOGIndexTerm: ENOG41118AQ
eggNOGDescriptionValue:
  AQN proteins mediate the binding of boar spermatozoa to component(s) of the egg's zona pellucida by a carbohydrate-binding mechanism. AQN proteins are secretory components of the male accessory glands being coated to the sperm surface at the time of ejaculation. They possess as well heparin-, serine-protease- inhibitor-binding capability


eggNOGIndexTerm: ENOG4111NFW
eggNOGDescriptionValue:
  Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the brca1-bard1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it is required for the complex integrity and its localization at DSBs. Probably also plays a role as a component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin. In these 2 complexes, it is probably required to maintain the stability of BRE BRCC45 and help the 'Lys-63'-linked deubiquitinase activity mediated by brcc3 brcc36 component


eggNOGIndexTerm: COG4354
eggNOGDescriptionValue:
  Non-lysosomal glucosylceramidase that catalyzes the conversion of glucosylceramide to free glucose and ceramide (By similarity)


eggNOGIndexTerm: ENOG410YN4N
eggNOGDescriptionValue:
  Plant lipoxygenase may be involved in a number of diverse aspects of plant physiology including growth and development, pest resistance, and senescence or responses to wounding (By similarity)


eggNOGIndexTerm: ENOG4110MNQ
eggNOGDescriptionValue:
  Has a role in localizing bicoid mRNA at the anterior margin of the oocyte during oogenesis, and a poorly characterized role in nuclear divisions in early embryogenesis


eggNOGIndexTerm: ENOG411205W
eggNOGDescriptionValue:
  Interacts with CbpA and inhibits both the DnaJ-like co- chaperone activity and the DNA binding activity of CbpA. Together with CbpA, modulates the activity of the DnaK chaperone system. Does not inhibit the co-chaperone activity of DnaJ (By similarity)


eggNOGIndexTerm: ENOG41126UY
eggNOGDescriptionValue:
  CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA)


eggNOGIndexTerm: COG1571
eggNOGDescriptionValue:
  ATP-dependent agmatine transferase that catalyzes the formation of 2-agmatinylcytidine (agm2C) at the wobble position (C34) of tRNA(Ile2), converting the codon specificity from AUG to AUA (By similarity)


eggNOGIndexTerm: ENOG4111D90
eggNOGDescriptionValue:
  Forms a polymeric layer at the periphery of the spindle pole body (SPB) central plaque which has an essential function during SPB duplication and may facilitate attachment of the SPB to the nuclear membrane (By similarity)


eggNOGIndexTerm: ENOG4111D9P
eggNOGDescriptionValue:
  Ribonuclease that specifically degrades pre-mRNAs with a defective 5' end cap and is part of a pre-mRNA capping quality control. Has decapping and 5'-3' exonuclease activities. Has decapping activity toward incomplete 5' end cap mRNAs such as unmethylated 5' end-capped RNA to release GpppN and 5' end monophosphate RNA. The 5' end monophosphate RNA is then degraded by the 5'-3' exoribonuclease activity, enabling this enzyme to decap and degrade incompletely capped mRNAs


eggNOGIndexTerm: ENOG410ZVNJ
eggNOGDescriptionValue:
  Necessary for the succinyl substitution of periplasmic glucans. Could catalyze the transfer of succinyl residues from the cytoplasmic side of the membrane to the nascent glucan backbones on the periplasmic side of the membrane (By similarity)


eggNOGIndexTerm: COG0003
eggNOGDescriptionValue:
  ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail- anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the membrane-bound receptor, and returning it to the cytosol to initiate a new round of targeting (By similarity)


eggNOGIndexTerm: COG0005
eggNOGDescriptionValue:
  The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity)


eggNOGIndexTerm: COG0008
eggNOGDescriptionValue:
  Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity)


eggNOGIndexTerm: ENOG4111KVF
eggNOGDescriptionValue:
  Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity)


eggNOGIndexTerm: ENOG4111FMJ
eggNOGDescriptionValue:
  ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells


eggNOGIndexTerm: COG2332
eggNOGDescriptionValue:
  Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH (By similarity)


eggNOGIndexTerm: COG2069
eggNOGDescriptionValue:
  Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2). Probably maintains the overall quaternary structure of the ACDS complex (By similarity)


eggNOGIndexTerm: COG2065
eggNOGDescriptionValue:
  Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant (By similarity)


eggNOGIndexTerm: ENOG410YXUU
eggNOGDescriptionValue:
  May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu(2 ) or ZN(2 ) for the ascorbate-mediated GPC1 deaminase degradation of its heparan sulfate side chains (By similarity)


eggNOGIndexTerm: COG0502
eggNOGDescriptionValue:
  Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity)


eggNOGIndexTerm: ENOG410XW2D
eggNOGDescriptionValue:
  Component of the U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates E complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region (By similarity)


eggNOGIndexTerm: COG0301
eggNOGDescriptionValue:
  Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity)


eggNOGIndexTerm: COG0304
eggNOGDescriptionValue:
  Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity)


eggNOGIndexTerm: ENOG4111YEM
eggNOGDescriptionValue:
  Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity)


eggNOGIndexTerm: ENOG4111ZXC
eggNOGDescriptionValue:
  Voltage-dependent rectifying anion channel that facilitates the translocation between chloroplast and cytoplasm of phosphorylated carbohydrates such as triosephosphate, 3- phosphoglycerate and inorganic phosphate (Pi) depending of ATP to triosephosphate ratio in the plastidial intermembrane space


eggNOGIndexTerm: COG0563
eggNOGDescriptionValue:
  Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity)


eggNOGIndexTerm: ENOG410ZTYC
eggNOGDescriptionValue:
  Transcriptional inhibitor with a significantly increased number of target genes in response to oleate (By similarity)


eggNOGIndexTerm: ENOG411245W
eggNOGDescriptionValue:
  ubiquitin-associated (UBA) TS-N domain-containing protein octicosapeptide Phox Bemp1 (PB1) domain-containing protein


eggNOGIndexTerm: ENOG410YDIG
eggNOGDescriptionValue:
  G proteins are involved as modulators or transducers in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. Involved in the determination of the cAMP level according to nutritional conditions, most probably as a regulator of cAMP phosphodiesterase. Required for the control of pseudohyphal and haploid invasive growth


eggNOGIndexTerm: ENOG41117EB
eggNOGDescriptionValue:
  Involved in export of poly(A) mRNAs from the nucleus. Recruited to the coding sequences as well as poly-A sites of active genes (By similarity)


eggNOGIndexTerm: ENOG410YREC
eggNOGDescriptionValue:
  Regulates the expression of several genes involved in acid resistance. Required for the expression of gadA and gadBC, among others, regardless of media or growth conditions. Binds directly to the 20 bp GAD box found in the control regions of both loci


eggNOGIndexTerm: ENOG410YG2Q
eggNOGDescriptionValue:
  Inhibits RpoS proteolysis by regulating RssB activity, thereby increasing the stability of the sigma stress factor RpoS during oxidative stress. Its effect on RpoS stability is due to its interaction with RssB, which probably blocks the interaction of RssB with RpoS, and the consequent delivery of the RssB-RpoS complex to the ClpXP protein degradation pathway


eggNOGIndexTerm: ENOG4111MW4
eggNOGDescriptionValue:
  Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The TF VIIa complex activates factors IX or X by specific limited protolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade


eggNOGIndexTerm: ENOG410XR95
eggNOGDescriptionValue:
  Transcription factor which regulates nonfermentable carbon utilization. Activator of gluconeogenetic genes (By similarity)


eggNOGIndexTerm: ENOG4111VB6
eggNOGDescriptionValue:
  Chaperone specialized in the storage of effectors within the bacterial cytoplasm, maintaining them in a secretion-competent state, and allowing their immediate delivery to target cells upon contact of the bacterium with the host cells. Has been shown to chaperone


eggNOGIndexTerm: ENOG411185M
eggNOGDescriptionValue:
  One of the components of the core antenna complex of photosystem II. It binds chlorophyll and helps catalyze the primary light-induced photochemical processes of photosystem II (By similarity)


eggNOGIndexTerm: ENOG410ZMD1
eggNOGDescriptionValue:
  Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2 3 complex (By similarity)


eggNOGIndexTerm: COG0201
eggNOGDescriptionValue:
  The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity)


eggNOGIndexTerm: COG0206
eggNOGDescriptionValue:
  Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity)


eggNOGIndexTerm: COG0208
eggNOGDescriptionValue:
  Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity)


eggNOGIndexTerm: ENOG410XNVG
eggNOGDescriptionValue:
  ATP-dependent RNA helicase involved in mRNA splicing. May destabilize the U1 5'-splice site duplex to permit an effective competition for the 5'-splice site by the U6 snRNA, resulting in the switch between U1 and U6 at the 5'-splice site. May also act to unwind the U4 U6 base-pairing interaction in the U4 U6 U5 snRNP, facilitating the first covalent step of splicing


eggNOGIndexTerm: ENOG410Y0RU
eggNOGDescriptionValue:
  Catalyzes the decarbonylation of fatty aldehydes to alkanes. Requires the presence of ferredoxin, ferredoxin reductase and NADPH for in vitro decarbonylase activity (By similarity). Involved in the biosynthesis of alkanes, mainly heptadecane and pentadecane


eggNOGIndexTerm: COG1867
eggNOGDescriptionValue:
  Dimethylates a single guanine residue at position 26 of a number of tRNAs using S-adenosyl-L-methionine as donor of the methyl groups (By similarity)


eggNOGIndexTerm: COG1868
eggNOGDescriptionValue:
  FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity)


eggNOGIndexTerm: ENOG410XVKS
eggNOGDescriptionValue:
  Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity)


eggNOGIndexTerm: ENOG4111DU8
eggNOGDescriptionValue:
  Component of the biogenesis of lysosome-related organelles complex-1 (BLOC-1) involved in endosomal cargo sorting (By similarity)


eggNOGIndexTerm: ENOG4111JFZ
eggNOGDescriptionValue:
  Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S- specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX (By similarity)


eggNOGIndexTerm: COG1005
eggNOGDescriptionValue:
  NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity)


eggNOGIndexTerm: ENOG41126WE
eggNOGDescriptionValue:
  Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity)


eggNOGIndexTerm: ENOG4111QHM
eggNOGDescriptionValue:
  those in tissues and body fluids are associated with the monocyte- macrophage system and enhance the activity of immunoagents


eggNOGIndexTerm: COG2041
eggNOGDescriptionValue:
  The exact function is not known. Can catalyze the reduction of a variety of substrates like dimethyl sulfoxide, trimethylamine N-oxide, phenylmethyl sulfoxide and L-methionine sulfoxide. Cannot reduce cyclic N-oxides. Shows no activity as sulfite oxidase (By similarity)


eggNOGIndexTerm: ENOG4111BH7
eggNOGDescriptionValue:
  Inhibitor of the DOA4 deubiquitinase involved in the regulation of protein degradation by the proteasome and maintenance of a normal level of free ubiquitin (By similarity)


eggNOGIndexTerm: ENOG410YDEI
eggNOGDescriptionValue:
  Involved in sperm-egg adhesion. Upon fertilization sperm must first penetrate a layer of cumulus cells that surrounds the egg before reaching the zona pellucida. The cumulus cells are embedded in a matrix containing hyaluronic acid which is formed prior to ovulation. This protein aids in penetrating the layer of cumulus cells by digesting hyaluronic acid


eggNOGIndexTerm: ENOG410YDEK
eggNOGDescriptionValue:
  Transcriptional activator of the xylanolytic system. Involved in the induction of a variety of cellulolytic and xylanolytic enzymes in the presence of their respective substrates. Binds to the DNA sequence 5'-GGCTAAA-3'


eggNOGIndexTerm: ENOG410ZEWX
eggNOGDescriptionValue:
  Stabilizes and promotes the formation of a nuclear actin cortical network. Stimulates actin polymerization in vitro by binding and stabilizing the pointed end of growing filaments. Inhibits beta-catenin activity by preventing its accumulation in the nucleus. Acts by influencing the nuclear accumulation of beta- catenin through a CRM1-dependent export pathway. Links centrosomes to the nuclear envelope via a microtubule association


eggNOGIndexTerm: COG0143
eggNOGDescriptionValue:
  Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity)


eggNOGIndexTerm: COG0148
eggNOGDescriptionValue:
  Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity)


eggNOGIndexTerm: ENOG410XXU3
eggNOGDescriptionValue:
  phage protein Ypo2111 SWALL Q8ZEP9 (EMBL AJ414151) (176 aa) fasta scores E() 4.1, 26.94 id in 167 aa


eggNOGIndexTerm: ENOG410ZRAD
eggNOGDescriptionValue:
  Transcription factor. Interacts specifically with the W box (5'-(T)TGAC CT -3'), a frequently occurring elicitor- responsive cis-acting element


eggNOGIndexTerm: ENOG4111BUC
eggNOGDescriptionValue:
  An odorant receptor which affects chemotaxis to the volatile odorant diacetyl. Specifies AWA neuronal cell fate via the odr-7 pathway


eggNOGIndexTerm: ENOG410YK9U
eggNOGDescriptionValue:
  Regulator of G protein-coupled receptor (GPCR) signaling. Probably acts by regulating the activity of some 'R7' family protein (RGS6, RGS7, RGS9 and or RGS11)


eggNOGIndexTerm: ENOG411096P
eggNOGDescriptionValue:
  Regulates the proliferation and differentiation of hematopoietic cells. Overexpression block the TPA-induced megakaryocytic differentiation in the K562 cell model. May also prevent cell apoptosis through the activation of the nuclear factor-kappa B (NF-kB)


eggNOGIndexTerm: COG2739
eggNOGDescriptionValue:
  Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein (By similarity)


eggNOGIndexTerm: COG1618
eggNOGDescriptionValue:
  Has nucleotide phosphatase activity towards ATP, GTP, CTP, TTP and UTP. May hydrolyze nucleoside diphosphates with lower efficiency (By similarity)


eggNOGIndexTerm: COG1612
eggNOGDescriptionValue:
  Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group (By similarity)


eggNOGIndexTerm: COG1614
eggNOGDescriptionValue:
  Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2) (By similarity)


eggNOGIndexTerm: COG0048
eggNOGDescriptionValue:
  Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity)


eggNOGIndexTerm: COG0043
eggNOGDescriptionValue:
  Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity)


eggNOGIndexTerm: COG0040
eggNOGDescriptionValue:
  Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity)


eggNOGIndexTerm: COG0041
eggNOGDescriptionValue:
  Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity)


eggNOGIndexTerm: ENOG41126D5
eggNOGDescriptionValue:
  mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space


eggNOGIndexTerm: ENOG4111363
eggNOGDescriptionValue:
  Acts downstream of daf-16 foxo to suppress tumors induced by disruption of gld-1. Potentially a direct target of daf-15 foxo


eggNOGIndexTerm: COG0486
eggNOGDescriptionValue:
  Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity)


eggNOGIndexTerm: COG2377
eggNOGDescriptionValue:
  Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity)


eggNOGIndexTerm: ENOG410Y4GN
eggNOGDescriptionValue:
  Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity)


eggNOGIndexTerm: ENOG41125ZV
eggNOGDescriptionValue:
  Stabilizes the structure of photosystem II oxygen- evolving complex (OEC), the ion environment of oxygen evolution and protects the OEC against heat-induced inactivation (By similarity)


eggNOGIndexTerm: ENOG4111VCR
eggNOGDescriptionValue:
  Resistance to gentamicin, tobramycin, and kanamycin. Tobramycin and kanamycin resistance is due to the ACC activity, specified by N-terminal region, and the gentamicin resistance is due to the APH activity encoded by the C-terminal region of the protein (By similarity)


eggNOGIndexTerm: ENOG410XTHE
eggNOGDescriptionValue:
  PagP is required both for biosynthesis of hepta-acylated lipid A species containing palmitate and for resistance to cationic antimicrobial peptides (CAMPs). It catalyzes the transfer of a palmitate chain (16 0) from the sn-1 position of a glycerophospholipid to the free hydroxyl group of the (R)-3- hydroxymyristate chain at position 2 of lipid A (endotoxin) (By similarity)


eggNOGIndexTerm: COG0522
eggNOGDescriptionValue:
  One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity)


eggNOGIndexTerm: COG0525
eggNOGDescriptionValue:
  amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity)


eggNOGIndexTerm: COG2219
eggNOGDescriptionValue:
  DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity)


eggNOGIndexTerm: COG1258
eggNOGDescriptionValue:
  Responsible for synthesis of pseudouridine from uracil- 54 and uracil-55 in the psi GC loop of transfer RNAs (By similarity)


eggNOGIndexTerm: ENOG4111819
eggNOGDescriptionValue:
  Required for kinetochore binding by a discrete subset of kMAPs and motors. Involved in kinetochore-microtubule binding and the spindle assembly checkpoint (By similarity)


eggNOGIndexTerm: COG1413
eggNOGDescriptionValue:
  Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)- L-lysine intermediate to form hypusine, an essential post- translational modification only found in mature eIF-5A factor (By similarity)


eggNOGIndexTerm: COG0249
eggNOGDescriptionValue:
  that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity)


eggNOGIndexTerm: COG0242
eggNOGDescriptionValue:
  Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity)


eggNOGIndexTerm: COG3785
eggNOGDescriptionValue:
  Involved in the degradation of certain denaturated proteins, including DnaA, during heat shock stress (By similarity)


eggNOGIndexTerm: ENOG411006J
eggNOGDescriptionValue:
  Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules (By similarity)


eggNOGIndexTerm: ENOG41125IT
eggNOGDescriptionValue:
  member of the soxRS regulon which mediates in part the increased levels of superoxide in response to oxidative stress


eggNOGIndexTerm: COG1270
eggNOGDescriptionValue:
  Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity)


eggNOGIndexTerm: COG0466
eggNOGDescriptionValue:
  ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity)


eggNOGIndexTerm: COG0468
eggNOGDescriptionValue:
  Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity)


eggNOGIndexTerm: ENOG4111VJB
eggNOGDescriptionValue:
  Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver


eggNOGIndexTerm: COG3343
eggNOGDescriptionValue:
  Participates in both the initiation and recycling phases of transcription. In the presence of the delta subunit, RNAP displays an increased specificity of transcription, a decreased affinity for nucleic acids, and an increased efficiency of RNA synthesis because of enhanced recycling (By similarity)


eggNOGIndexTerm: COG5057
eggNOGDescriptionValue:
  PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Acts as a regulatory subunit for PP2A-like phosphatases modulating their activity or substrate specificity, probably by inducing a conformational change in the catalytic subunit, a direct target of the PPIase. Can reactivate inactive phosphatase PP2A-phosphatase methylesterase complexes (PP2Ai) in presence of ATP and Mg(2 ) by dissociating the inactive form from the complex (By similarity)


eggNOGIndexTerm: ENOG41102PY
eggNOGDescriptionValue:
  Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER (By similarity)


eggNOGIndexTerm: ENOG4112CMI
eggNOGDescriptionValue:
  Mediates binding to human platelets, possibly through a receptor-ligand interaction. Probably associated with virulence in endovascular infection (By similarity)


eggNOGIndexTerm: ENOG410XQS2
eggNOGDescriptionValue:
  Plays a role in maintaining the mitochondrial genome and in controlling the mtDNA escape. Involved in the regulation of mtDNA nucleotide structure and number. May have a dispensable role in early maturation of pre-rRNA (By similarity)


eggNOGIndexTerm: COG2896
eggNOGDescriptionValue:
  Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)


eggNOGIndexTerm: ENOG41112S2
eggNOGDescriptionValue:
  Cardioactive peptide. Corazonin is probably involved in the physiological regulation of the heart beat. Clock (Clk) and cycle (cyc) proteins negatively regulate Crz transcription in a cell-specific manner


eggNOGIndexTerm: COG1537
eggNOGDescriptionValue:
  May function in recognizing stalled ribosomes, interact with stem-loop structures in stalled mRNA molecules, and effect endonucleolytic cleavage of the mRNA. May play a role in the release non-functional ribosomes and degradation of damaged mRNAs. Has endoribonuclease activity (By similarity)


eggNOGIndexTerm: ENOG410XT0I
eggNOGDescriptionValue:
  PsaA and PsaB bind P700, the primary electron donor of photosystem I (PSI), as well as the electron acceptors A0, A1 and FX. PSI is a plastocyanin cytochrome c6-ferredoxin oxidoreductase, converting photonic excitation into a charge separation, which transfers an electron from the donor P700 chlorophyll pair to the spectroscopically characterized acceptors A0, A1, FX, FA and FB in turn. Oxidized P700 is reduced on the lumenal side of the thylakoid membrane by plastocyanin or cytochrome c6


eggNOGIndexTerm: ENOG4112D2K
eggNOGDescriptionValue:
  Its presence in a non-photosynthetic plant (Epifagus virginiana) and experiments in tobacco indicate that it may have a function which is probably not related to photosynthesis


eggNOGIndexTerm: ENOG41103N7
eggNOGDescriptionValue:
  1,4)-beta-D-glucans synthesis in grasses and cereals (Poaceae). The mixed-linked glucans (which are not present in walls of dicotyledons or most other monocotyledonous plants) are particularly important constituents of the walls of the starchy endosperm and aleurone cells of cereal grains such as oats, wheat, rice and barley. They can account for up to 70 by weight of the wall


eggNOGIndexTerm: ENOG410Z4N5
eggNOGDescriptionValue:
  Binds 5 molecules of zinc. May have a role in Zn(2 ) homeostasis during embryogenesis (By similarity)


eggNOGIndexTerm: ENOG4110P1J
eggNOGDescriptionValue:
  Metallothioneins have a high content of cysteine residues that bind various heavy metals (By similarity)


eggNOGIndexTerm: ENOG410Y5P5
eggNOGDescriptionValue:
  Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(1) domain and of the central stalk which is part of the complex rotary element. Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits


eggNOGIndexTerm: ENOG410XV0S
eggNOGDescriptionValue:
  guanine nucleotide exchange factor (GEF). This activation results in actin cytoskeleton rearrangements and stimulates membrane ruffling


eggNOGIndexTerm: COG3709
eggNOGDescriptionValue:
  Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP) (By similarity)


eggNOGIndexTerm: COG3705
eggNOGDescriptionValue:
  Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity)


eggNOGIndexTerm: ENOG4111FEZ
eggNOGDescriptionValue:
  Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity)


eggNOGIndexTerm: ENOG4111CNW
eggNOGDescriptionValue:
  Plays a role in autophagy. Functions at the preautophagosomal structure (PAS) in order to form normal autophagosomes under starvation conditions. Plays also a role in mitophagy and regulation of filamentous growth (By similarity)


eggNOGIndexTerm: ENOG410XP69
eggNOGDescriptionValue:
  Specifically deglycosylates the denatured form of N- linked glycoproteins in the cytoplasm and assists their proteasome-mediated degradation. Cleaves the beta-aspartyl- glucosamine (GlcNAc) of the glycan and the amide side chain of Asn, converting Asn to Asp. Prefers proteins containing high- mannose over those bearing complex type oligosaccharides. Can recognize misfolded proteins in the endoplasmic reticulum that are exported to the cytosol to be destroyed and deglycosylate them, while it has no activity toward native proteins. Deglycosylation is a prerequisite for subsequent proteasome-mediated degradation of some, but not all, misfolded glycoproteins


eggNOGIndexTerm: ENOG410XP6Y
eggNOGDescriptionValue:
  The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Necessary for proper vacuole morphology. Plays an important role in osmotically-induced vacuole fragmentation. Required for cytoplasm to vacuole transport (Cvt) vesicle formation, pexophagy and starvation-induced autophagy. Involved in correct atg9 trafficking to the pre-autophagosomal structure. Might also be involved in premeiotic DNA replication (By similarity)


eggNOGIndexTerm: ENOG410XSBK
eggNOGDescriptionValue:
  Component of the ERMES MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis and may function in phospholipid exchange. The mdm12-mmm1 subcomplex functions in the major beta-barrel assembly pathway that is responsible for biogenesis of all outer membrane beta-barrel proteins, and acts in a late step after the SAM complex. The mdm10-mdm12-mmm1 subcomplex further acts in the TOM40-specific pathway after the action of the mdm12-mmm1 complex. Essential for establishing and maintaining the structure of mitochondria and maintenance of mtDNA nucleoids (By similarity)


eggNOGIndexTerm: ENOG410XZDZ
eggNOGDescriptionValue:
  tRNA nucleus export receptor which facilitates tRNA translocation across the nuclear pore complex. Involved in pre- tRNA splicing, probably by affecting the interaction of pre-tRNA with splicing endonuclease (By similarity)


eggNOGIndexTerm: ENOG4111CN5
eggNOGDescriptionValue:
  S100A8 is a calcium- and zinc-binding protein which plays a prominent role in the regulation of inflammatory processes and immune response. It can induce neutrophil chemotaxis and adhesion. Predominantly found as calprotectin (S100A8 A9) which has a wide plethora of intra- and extracellular functions. The intracellular functions include facilitating leukocyte arachidonic acid trafficking and metabolism, modulation of the tubulin-dependent cytoskeleton during migration of phagocytes and activation of the neutrophilic NADPH-oxidase. Activates NADPH- oxidase by facilitating the enzyme complex assembly at the cell membrane, transfering arachidonic acid, an essential cofactor, to the enzyme complex and S100A8 contributes to the enzyme assembly by directly binding to NCF2 P67PHOX. The extracellular functions involve proinfammatory, antimicrobial, oxidant-scavenging and apoptosis-inducing activities. Its proinflammatory activity includes recruitment of leukocytes, promotion of cytokine and chemokine production, and regulation of leukocyte adhesion and migration. Acts as an alarmin or a danger associated molecular pattern (DAMP) molecule and stimulates innate immune cells via binding to pattern recognition receptors such as Toll-like receptor 4 (TLR4) and receptor for advanced glycation endproducts (AGER). Binding to TLR4 and AGER activates the MAP-kinase and NF- kappa-B signaling pathways resulting in the amplification of the proinflammatory cascade. Has antimicrobial activity towards bacteria and fungi and exerts its antimicrobial activity probably via chelation of Zn(2 ) which is essential for microbial growth. Can induce cell death via autophagy and apoptosis and this occurs through the cross-talk of mitochondria and lysosomes via reactive oxygen species (ROS) and the process involves BNIP3. Can regulate neutrophil number and apoptosis by an anti-apoptotic effect


eggNOGIndexTerm: COG0389
eggNOGDescriptionValue:
  Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity)


eggNOGIndexTerm: ENOG410Y16G
eggNOGDescriptionValue:
  Recognizes and binds the palindromic sequence 5'- TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication (By similarity)


eggNOGIndexTerm: ENOG4111YMR
eggNOGDescriptionValue:
  Inhibits RpoS proteolysis by regulating RssB activity, thereby increasing the stability of the sigma stress factor RpoS especially during phosphate starvation, but also in stationary phase and during nitrogen starvation. Its effect on RpoS stability is due to its interaction with RssB, which probably blocks the interaction of RssB with RpoS, and the consequent delivery of the RssB-RpoS complex to the ClpXP protein degradation pathway (By similarity)


eggNOGIndexTerm: ENOG4111CY7
eggNOGDescriptionValue:
  CONTAINS InterPro DOMAIN s Uncharacterised protein family UPF0497, trans-membrane plant (InterPro IPR006702), Uncharacterised protein family UPF0497, trans-membrane plant subgroup (InterPro IPR006459)


eggNOGIndexTerm: ENOG41117FG
eggNOGDescriptionValue:
  Mitophagy-specific receptor that recruits the autophagic machinery to mitochondria and regulates selective degradation of mitochondria. Mitophagy contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Recruits ATG11 to the surface of mitochondria. Promotes also autophagy-dependent peroxisome degradation (By similarity)


eggNOGIndexTerm: ENOG410XW09
eggNOGDescriptionValue:
  Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity)


eggNOGIndexTerm: COG2941
eggNOGDescriptionValue:
  Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol (By similarity)


eggNOGIndexTerm: COG3006
eggNOGDescriptionValue:
  Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity (By similarity)


eggNOGIndexTerm: COG2255
eggNOGDescriptionValue:
  The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity)


eggNOGIndexTerm: COG1513
eggNOGDescriptionValue:
  Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide (By similarity)


eggNOGIndexTerm: COG1515
eggNOGDescriptionValue:
  Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. Acts in DNA repair (By similarity)


eggNOGIndexTerm: COG1892
eggNOGDescriptionValue:
  Catalyzes the irreversible beta-carboxylation of phosphoenolpyruvate (PEP) to form oxaloacetate (OAA), a four- carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity)


eggNOGIndexTerm: ENOG41104P9
eggNOGDescriptionValue:
  required for pollen fertility and development. Active in both diploid tapetum and haploid microspores


eggNOGIndexTerm: ENOG410YBAU
eggNOGDescriptionValue:
  TS is a member of the terpene cyclase group of enzymes. It catalyzes the isomerization and cyclization of farnesyl pyro- phosphate to form trichodiene, the first cyclic intermediate in the biosynthetic pathway for trichothecenes. It serves to branch trichothecene biosynthesis from the isoprenoid pathway


eggNOGIndexTerm: COG0289
eggNOGDescriptionValue:
  Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity)


eggNOGIndexTerm: ENOG410YEUK
eggNOGDescriptionValue:
  Catalyzes the intramolecular cyclization of bicyclic chalcones into tricyclic (S)-flavanones. Responsible for the isomerization of 4,2',4',6'-tetrahydroxychalcone (also termed chalcone) into naringenin


eggNOGIndexTerm: COG0421
eggNOGDescriptionValue:
  Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity)


eggNOGIndexTerm: COG3107
eggNOGDescriptionValue:
  Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1A (PBP1a) (By similarity)


eggNOGIndexTerm: ENOG410YQHR
eggNOGDescriptionValue:
  Calcium-dependent lectin involved in innate immune defense. Binds mannose, fucose and N-acetylglucosamine on different microorganisms and activates the lectin complement pathway. Binds to late apoptotic cells, as well as to apoptotic blebs and to necrotic cells, but not to early apoptotic cells, facilitating their uptake by macrophages


eggNOGIndexTerm: ENOG410ZQHK
eggNOGDescriptionValue:
  Interacts with MUS81 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'- flap structures, D-loops, replication forks, nicked Holliday junctions and also intact Holliday junctions with a reduced efficiency. May be required in mitosis for the processing of stalled or collapsed replication fork intermediates. Plays a role in DNA repair and in genotoxic stress-induced homologous recombination (HR) in somatic cells. Mediates a subset of meiotic recombination events that are insensitive to crossover interference


eggNOGIndexTerm: ENOG4110KCD
eggNOGDescriptionValue:
  Has a role in a nucleosome assembly pathway that is required for the integrity of heterochromatin and proper chromosome segregation


eggNOGIndexTerm: COG5424
eggNOGDescriptionValue:
  Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ (By similarity)


eggNOGIndexTerm: ENOG4111PBJ
eggNOGDescriptionValue:
  Toxic component of a toxin-antitoxin (TA) module. Overexpression results in inhibition of growth in liquid cultures


eggNOGIndexTerm: ENOG410XT4Z
eggNOGDescriptionValue:
  Involved in vacuolar transport and vacuole pH homeostasis. Also required for cytokinesis (By similarity)


eggNOGIndexTerm: ENOG41115BI
eggNOGDescriptionValue:
  Primordial germ cell (PGCs)-specific protein involved in epigenetic chromatin reprogramming in the zygote following fertilization. In zygotes, DNA demethylation occurs selectively in the paternal pronucleus before the first cell division, while the adjacent maternal pronucleus and certain paternally-imprinted loci are protected from this process. Participates in protection of DNA methylation in the maternal pronucleus by preventing conversion of 5mC to 5hmC specifically recognizes and binds histone H3 dimethylated at 'Lys-9' (H3K9me2) on maternal genome, and protects maternal genome from TET3-mediated conversion to 5hmC and subsequent DNA demethylation. Does not bind paternal chromatin, which is mainly packed into protamine and does not contain much H3K9me2 mark. Also protects imprinted loci that are marked with H3K9me2 in mature sperm from DNA demethylation in early embryogenesis. May be important for the totipotent pluripotent states continuing through preimplantation development. Also involved in chromatin condensation in oocytogenesis


eggNOGIndexTerm: ENOG410XRWI
eggNOGDescriptionValue:
  Signal-recognition-particle assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum membrane (By similarity)


eggNOGIndexTerm: COG1354
eggNOGDescriptionValue:
  Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity)


eggNOGIndexTerm: COG1351
eggNOGDescriptionValue:
  Catalyzes the formation of dTMP and tetrahydrofolate from dUMP and methylenetetrahydrofolate (By similarity)


eggNOGIndexTerm: COG0707
eggNOGDescriptionValue:
  Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity)


eggNOGIndexTerm: COG0722
eggNOGDescriptionValue:
  Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity)


eggNOGIndexTerm: ENOG41124U3
eggNOGDescriptionValue:
  it directly binds FlhC, thus inhibiting the binding of the FlhC FlhD complex to class 2 promoters, resulting in decreased expression of class 2 flagellar operons. As a chaperone, effects FliD transition to the membrane by preventing its premature polymerization, and by directing it to the export apparatus (By similarity)


eggNOGIndexTerm: ENOG41124UZ
eggNOGDescriptionValue:
  Single-stranded DNA-binding protein that functions in both chloroplasts and nucleus. In chloroplasts, maintains plastid genome stability by preventing break-induced and short homology- dependent illegitimate recombinations. In


eggNOGIndexTerm: ENOG41124UG
eggNOGDescriptionValue:
  Is required to sustain N(2)-dependent growth in the presence of low levels of carbon monoxide (CO). Probably acts by protecting the N(2) fixation ability of the nitrogenase complex, which is inactivated in the presence of CO (By similarity)


eggNOGIndexTerm: COG4670
eggNOGDescriptionValue:
  CoA transferase having broad substrate specificity for short-chain acyl-CoA thioesters with the activity decreasing when the length of the carboxylic acid chain exceeds four carbons (By similarity)


eggNOGIndexTerm: ENOG4111G3S
eggNOGDescriptionValue:
  Mediates the side-chain deamidation of N-terminal glutamine residues to glutamate, an important step in N-end rule pathway of protein degradation. Conversion of the resulting N- terminal glutamine to glutamate renders the protein susceptible to arginylation, polyubiquitination and degradation as specified by the N-end rule. Does not act on substrates with internal or C- terminal glutamine and does not act on non-glutamine residues in any position


eggNOGIndexTerm: ENOG410XQBE
eggNOGDescriptionValue:
  Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Cycles between the PAS and the cytoplasmic vesicle pool and may participate in supplying membrane for the growing autophagosome


eggNOGIndexTerm: ENOG4110AP6
eggNOGDescriptionValue:
  Bifunctional nuclease with both RNase and DNase activites. Involved in basal defense response. Participates in abscisic acid-derived callose deposition following infection by a necrotrophic pathogen


eggNOGIndexTerm: COG5136
eggNOGDescriptionValue:
  Component of the U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA


eggNOGIndexTerm: ENOG410YDM5
eggNOGDescriptionValue:
  PsaA and PsaB bind P700, the primary electron donor of photosystem I (PSI), as well as the electron acceptors A0, A1 and FX. PSI is a plastocyanin cytochrome c6-ferredoxin oxidoreductase, converting photonic excitation into a charge separation, which transfers an electron from the donor P700 chlorophyll pair to the spectroscopically characterized acceptors A0, A1, FX, FA and FB in turn. Oxidized P700 is reduced on the lumenal side of the thylakoid membrane by plastocyanin or cytochrome c6 (By similarity)


eggNOGIndexTerm: ENOG4111R2M
eggNOGDescriptionValue:
  Calsequestrin is a high-capacity, moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle. The release of calcium bound to calsequestrin through a calcium release channel triggers muscle contraction (By similarity)


eggNOGIndexTerm: COG2825
eggNOGDescriptionValue:
  Molecular chaperone that interacts specifically with outer membrane proteins, thus maintaining the solubility of early folding intermediates during passage through the periplasm (By similarity)


eggNOGIndexTerm: ENOG4111EE1
eggNOGDescriptionValue:
  Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery


eggNOGIndexTerm: COG1730
eggNOGDescriptionValue:
  Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding (By similarity)


eggNOGIndexTerm: COG1734
eggNOGDescriptionValue:
  Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters


eggNOGIndexTerm: ENOG410Y94S
eggNOGDescriptionValue:
  Specific in hydrolyzing the terminal glycosidic bond of polygalacturonic acid and oligogalacturonates (By similarity)


eggNOGIndexTerm: COG3642
eggNOGDescriptionValue:
  Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)


eggNOGIndexTerm: COG3648
eggNOGDescriptionValue:
  Catalyzes the oxidation of uric acid to 5- hydroxyisourate, which is further processed to form (S)-allantoin (By similarity)


eggNOGIndexTerm: ENOG410ZZIC
eggNOGDescriptionValue:
  Component of the SCF(sconB) E3 ubiquitin ligase complex involved in the regulation of sulfur metabolite repression, probably by mediating the inactivation or degradation of the metR transcription factor


eggNOGIndexTerm: ENOG410ZEBS
eggNOGDescriptionValue:
  Functions as component of the transcription regulatory histone acetylation (HAT) complex SAGA. At the promoters, SAGA is required for recruitment of the basal transcription machinery. It influences RNA polymerase II transcriptional activity through different activities such as TBP interaction and promoter selectivity, interaction with transcription activators, and chromatin modification through histone acetylation and deubiquitination. SAGA acetylates nucleosomal histone H3 to some extent (to form H3K9ac, H3K14ac, H3K18ac and H3K23ac). SAGA interacts with DNA via upstream activating sequences (UASs). Involved in transcriptional regulation of a subset of SAGA- regulated genes. Within the SAGA complex, participates in a subcomplex, that specifically deubiquitinates histones H2B (By similarity)


eggNOGIndexTerm: COG0193
eggNOGDescriptionValue:
  The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity)


eggNOGIndexTerm: COG0197
eggNOGDescriptionValue:
  Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity)


eggNOGIndexTerm: COG0198
eggNOGDescriptionValue:
  One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity)


eggNOGIndexTerm: COG0199
eggNOGDescriptionValue:
  Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity)


eggNOGIndexTerm: ENOG410XY8U
eggNOGDescriptionValue:
  Outer membrane channel protein allowing the entry of N- acetylneuraminic acid (Neu5Ac, the most abundant sialic acid on host cell surfaces) into the bacteria


eggNOGIndexTerm: ENOG410XY8D
eggNOGDescriptionValue:
  In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high- sulfur and high-glycine-tyrosine keratins


eggNOGIndexTerm: ENOG410YK12
eggNOGDescriptionValue:
  Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity)


eggNOGIndexTerm: ENOG410XWB2
eggNOGDescriptionValue:
  RNA polymerase II degradation factor recruits the ubiquitination machinery to the RNA polymerase II for polyubiquitination, removal and degradation, when RAD26 fails to efficiently displace stalled RNA polymerase II. Also involved in telomere length regulation (By similarity)


eggNOGIndexTerm: ENOG4110KZ2
eggNOGDescriptionValue:
  Works in parallel with axl-1 in negatively regulating bar-1 signaling in vulval precursor cells and Q neuroblasts. Inhibits Wnt signaling, which affects tissue specific expression of Hox genes, egl-5, lin-39 and mab-5. This in turn affects QR (postembryonic neuroblast) cell migration, vulval cell fate specification, and the development of sensory structures by the seam cell lineage. Has a role in alae V cell patterning, ray formation in the male tail and axon guidance. Does not affect B cell polarity


eggNOGIndexTerm: ENOG410YGQ6
eggNOGDescriptionValue:
  Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility


eggNOGIndexTerm: ENOG41118PI
eggNOGDescriptionValue:
  Required for translation of the mitochondrial OLI1 transcript coding for the mitochondrial ATP synthase subunit 9 (By similarity)


eggNOGIndexTerm: ENOG4111P4F
eggNOGDescriptionValue:
  Guanylyltransferase that catalyzes the activation of 2- phospho-L-lactate (LP) as (2S)-lactyl-2-diphospho-5'-guanosine (LPPG), via the condensation of LP with GTP. Is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor (By similarity)


eggNOGIndexTerm: ENOG410Z26V
eggNOGDescriptionValue:
  Major structure protein of the hrp pilus, which is a component of the type III secretion system (TTSS, Hrp secretion system) required for effector protein delivery, parasitism, and pathogenicity. The hrp pilus functions as a conduit for protein delivery into the host cell (By similarity)


eggNOGIndexTerm: ENOG410XW4M
eggNOGDescriptionValue:
  One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA (By similarity)


eggNOGIndexTerm: ENOG4112694
eggNOGDescriptionValue:
  Together with AlgI and AlgJ, forms an inner membrane complex which probably interacts with the alginate polymerization- transport complex and adds acetyl groups at the O-2 and O-3 positions of polymannuronic acid. Acetylation of alginate is important for the architecture of biofilms and increases


eggNOGIndexTerm: COG4232
eggNOGDescriptionValue:
  Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity)


eggNOGIndexTerm: ENOG4110SD6
eggNOGDescriptionValue:
  Cecropins have lytic and antibacterial activity against several Gram-positive and Gram-negative bacteria


eggNOGIndexTerm: ENOG4110IP8
eggNOGDescriptionValue:
  Works in parallel with pry-1 in negatively regulating bar-1 signaling in vulval precursor cells and Q neuroblasts. Shown to have a role in excretory cell development


eggNOGIndexTerm: COG5333
eggNOGDescriptionValue:
  Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Binds to and activates cyclin-dependent kinase cdk8 that phosphorylates the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex


eggNOGIndexTerm: COG1921
eggNOGDescriptionValue:
  Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis (By similarity)


eggNOGIndexTerm: ENOG4111B5T
eggNOGDescriptionValue:
  Plays a central role in chromosome cohesion during cell division by preventing premature dissociation of cohesin complex from centromeres after prophase, when most of cohesin complex dissociates from chromosomes arms (By similarity)


eggNOGIndexTerm: ENOG410YI1X
eggNOGDescriptionValue:
  Involved in transport from the ER to the Golgi apparatus as well as in intra-Golgi transport. It belongs to a super-family of proteins called t-SNAREs or soluble NSF (N-ethylmaleimide- sensitive factor) attachment protein receptor (By similarity)


eggNOGIndexTerm: COG1495
eggNOGDescriptionValue:
  Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity)


eggNOGIndexTerm: COG1492
eggNOGDescriptionValue:
  catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity)


eggNOGIndexTerm: COG1490
eggNOGDescriptionValue:
  Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity)


eggNOGIndexTerm: ENOG41118KS
eggNOGDescriptionValue:
  Component of the SWR1 complex which mediates the ATP- dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling


eggNOGIndexTerm: COG3297
eggNOGDescriptionValue:
  Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins (By similarity)


eggNOGIndexTerm: ENOG4110SQU
eggNOGDescriptionValue:
  found in the royal jelly which is the food of the queen honey bee larva. The royal jelly determines the development of the young larvae and is responsible for the high reproductive ability of the honeybee queen


eggNOGIndexTerm: COG4512
eggNOGDescriptionValue:
  Essential for the production of a quorum sensing system signal molecule, the autoinducing peptide (AIP). This quorum sensing system is responsible for the regulation of the expression of virulence factor genes. Involved in the proteolytic processing of AgrD, the precursor of AIP (By similarity)


eggNOGIndexTerm: COG3143
eggNOGDescriptionValue:
  Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P) (By similarity)


eggNOGIndexTerm: ENOG4111DAE
eggNOGDescriptionValue:
  In complex with MON1, is required for multiple vacuole delivery pathways including the cytoplasm to vacuole transport (Cvt), autophagy, pexophagy and endocytosis (By similarity). The CCZ1-MON1 complex acts at the fusion of vesicles with the vacuole, through its regulation of the SNARE complex during the coordinated priming and docking stages of fusion, and particularly at the stage of tethering docking (By similarity)


eggNOGIndexTerm: ENOG4111C30
eggNOGDescriptionValue:
  S100A9 is a calcium- and zinc-binding protein which plays a prominent role in the regulation of inflammatory processes and immune response. It can induce neutrophil chemotaxis, adhesion, can increase the bactericidal activity of neutrophils by promoting phagocytosis via activation of SYK, PI3K AKT, and ERK1 2 and can induce degranulation of neutrophils by a MAPK-dependent mechanism. Predominantly found as calprotectin (S100A8 A9) which has a wide plethora of intra- and extracellular functions. The intracellular functions include facilitating leukocyte arachidonic acid trafficking and metabolism, modulation of the tubulin-dependent cytoskeleton during migration of phagocytes and activation of the neutrophilic NADPH-oxidase. Activates NADPH- oxidase by facilitating the enzyme complex assembly at the cell membrane, transfering arachidonic acid, an essential cofactor, to the enzyme complex and S100A8 contributes to the enzyme assembly by directly binding to NCF2 P67PHOX. The extracellular functions involve proinfammatory, antimicrobial, oxidant-scavenging and apoptosis-inducing activities. Its proinflammatory activity includes recruitment of leukocytes, promotion of cytokine and chemokine production, and regulation of leukocyte adhesion and migration. Acts as an alarmin or a danger associated molecular pattern (DAMP) molecule and stimulates innate immune cells via binding to pattern recognition receptors such as Toll-like receptor 4 (TLR4) and receptor for advanced glycation endproducts (AGER). Binding to TLR4 and AGER activates the MAP-kinase and NF- kappa-B signaling pathways resulting in the amplification of the proinflammatory cascade. Has antimicrobial activity towards bacteria and fungi and exerts its antimicrobial activity probably via chelation of Zn(2 ) which is essential for microbial growth. Can induce cell death via autophagy and apoptosis and this occurs through the cross-talk of mitochondria and lysosomes via reactive oxygen species (ROS) and the process involves BNIP3. Can regulate neutrophil number and apoptosis by an anti-apoptotic effect


eggNOGIndexTerm: ENOG4111C3P
eggNOGDescriptionValue:
  CONTAINS InterPro DOMAIN s Development and cell death domain (InterPro IPR013989), Kelch related (InterPro IPR013089)


eggNOGIndexTerm: ENOG4110DNE
eggNOGDescriptionValue:
  Dioxygenase that catalyzes the first step of DNA base J (beta-d-glucosyl-HOMedU) biosynthesis by converting thymine to 5- hydroxymethyluracil (HOMedU). DNA base J is a hypermodified thymidine residue found in the genome of kinetoplastid parasites, which is localized primarily to repetitive DNA, namely the telomeres, and is implicated in the regulation of antigenic variation. Also specifically binds to base J-containing DNA (J- DNA). Involved in propagation and maintenance of DNA base J synthesis initiated by JBP2 by specifically binding already synthesized DNA base J and propagating J synthesis. Thymine dioxygenase activity and J-DNA-binding are independent functions


eggNOGIndexTerm: ENOG410XTRF
eggNOGDescriptionValue:
  Erythropoietin is the principal hormone involved in the regulation of erythrocyte differentiation and the maintenance of a physiological level of circulating erythrocyte mass


eggNOGIndexTerm: ENOG410XTR6
eggNOGDescriptionValue:
  Protease that can act as an efficient and specific deubiquitinating enzyme in vitro. Does not possess desumoylating and deneddylating activities. The physiological substrate is


eggNOGIndexTerm: COG2924
eggNOGDescriptionValue:
  Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes (By similarity)


eggNOGIndexTerm: ENOG411141B
eggNOGDescriptionValue:
  Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair


eggNOGIndexTerm: ENOG4111AMM
eggNOGDescriptionValue:
  Stimulates formation of NaHCO(3)-rich pancreatic juice and secretion of NaHCO(3)-rich bile and inhibits HCl production by the stomach


eggNOGIndexTerm: ENOG41119RW
eggNOGDescriptionValue:
  Negative regulatory component of the MBF complex involved in cell-cycle-dependent transcription (By similarity)


eggNOGIndexTerm: COG0769
eggNOGDescriptionValue:
  Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity)


eggNOGIndexTerm: COG0764
eggNOGDescriptionValue:
  Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity)


eggNOGIndexTerm: COG0761
eggNOGDescriptionValue:
  Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity)


eggNOGIndexTerm: ENOG41100CH
eggNOGDescriptionValue:
  component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair


eggNOGIndexTerm: ENOG4111QDV
eggNOGDescriptionValue:
  ABC-type transport system involved in multi-copper enzyme maturation permease component-like protein


eggNOGIndexTerm: ENOG410XX48
eggNOGDescriptionValue:
  Required for the assembly of the V0 complex of the vacuolar ATPase (V-ATPase) in the endoplasmic reticulum (By similarity)


eggNOGIndexTerm: ENOG41120GX
eggNOGDescriptionValue:
  complex is a palmitoyltransferase specific for Ras proteins. Palmitoylates RAS2, which is required for its proper plasma membrane localization


eggNOGIndexTerm: ENOG4111NEJ
eggNOGDescriptionValue:
  Catalyzes the circularization of gamma-N-acetyl- alpha,gamma-diaminobutyric acid (ADABA) to ectoine (1,4,5,6- tetrahydro-2-methyl-4-pyrimidine carboxylic acid), which is an excellent osmoprotectant (By similarity)


eggNOGIndexTerm: COG1690
eggNOGDescriptionValue:
  Catalytic subunit of the tRNA-splicing ligase complex that acts by directly joining spliced tRNA halves to mature-sized tRNAs by incorporating the precursor-derived splice junction phosphate into the mature tRNA as a canonical 3',5'- phosphodiester. May act as a RNA ligase with broad substrate specificity, and may function toward other RNAs (By similarity)


eggNOGIndexTerm: ENOG410ZH91
eggNOGDescriptionValue:
  Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes a protein kinase and an oligoadenylate synthetase


eggNOGIndexTerm: ENOG410YPMH
eggNOGDescriptionValue:
  Alpha-toxin binds to the membrane of eukaryotic cells resulting in the release of low-molecular weight molecules and leading to an eventual osmotic lysis. Heptamer oligomerization and pore formation is required for lytic activity


eggNOGIndexTerm: ENOG410XRD5
eggNOGDescriptionValue:
  Outer membrane channel protein that allows an efficient diffusion of low-molecular-weight solutes such as small sugars and tetraglycine. However, the specific substrate recognized by the OmpL channel is


eggNOGIndexTerm: ENOG410ZKHT
eggNOGDescriptionValue:
  Involved in the initiation of assembly of the COPII coat required for the formation of transport vesicles from the endoplasmic reticulum (ER) and the selection of cargo molecules. Also involved in autophagy (By similarity)


eggNOGIndexTerm: ENOG4111ZFI
eggNOGDescriptionValue:
  Catalyzes diesterification of phthiocerol and phthiodiolone with mycocerosic acids, the final step in the phthiocerol and phthiodiolone dimycocerosate esters (PDIM) synthesis


eggNOGIndexTerm: COG1038
eggNOGDescriptionValue:
  Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity)


eggNOGIndexTerm: ENOG410Y45Y
eggNOGDescriptionValue:
  Catalyzes the four-electron reduction of biliverdin IX- alpha (2-electron reduction at both the A and D rings)


eggNOGIndexTerm: ENOG4111S2F
eggNOGDescriptionValue:
  Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed to be not involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone


eggNOGIndexTerm: ENOG41126PD
eggNOGDescriptionValue:
  Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations (By


eggNOGIndexTerm: COG1017
eggNOGDescriptionValue:
  Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity)


eggNOGIndexTerm: ENOG410YGU3
eggNOGDescriptionValue:
  Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with NCS6 that ligates sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. May also be involved in protein urmylation (By similarity)


eggNOGIndexTerm: COG0774
eggNOGDescriptionValue:
  involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)


eggNOGIndexTerm: COG0777
eggNOGDescriptionValue:
  Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity)


eggNOGIndexTerm: ENOG4110NY0
eggNOGDescriptionValue:
  May stabilize HDL (high density lipoprotein) structure by its association with lipids, and affect the HDL metabolism


eggNOGIndexTerm: ENOG4112005
eggNOGDescriptionValue:
  Essential for the assembly of ubiquinol-cytochrome c reductase. It has a direct effect on the correct occurrence of the Rieske protein, core 4, core 5 and apocytochrome b (By similarity)


eggNOGIndexTerm: COG0284
eggNOGDescriptionValue:
  Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity)


eggNOGIndexTerm: ENOG41105GK
eggNOGDescriptionValue:
  Component of the ERMES MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis and may function in phospholipid exchange. mdm34 is required for the interaction of the ER-resident membrane protein mmm1 and the outer mitochondrial membrane-resident beta-barrel protein mdm10 (By similarity)


eggNOGIndexTerm: ENOG4111YUJ
eggNOGDescriptionValue:
  Usually encoded in the trnK tRNA gene intron. Probably assists in splicing its own and other chloroplast group II introns (By similarity)


eggNOGIndexTerm: COG2403
eggNOGDescriptionValue:
  Catalyzes the formation of cyclic 2,3-diphosphoglycerate (cDPG) by formation of an intramolecular phosphoanhydride bond at the expense of ATP


eggNOGIndexTerm: ENOG4111FRE
eggNOGDescriptionValue:
  Secreted metalloproteinase that allows assimilation of proteinaceous substrates. Shows high activities on basic nuclear substrates such as histone and protamine


eggNOGIndexTerm: COG2101
eggNOGDescriptionValue:
  General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation (By similarity)


eggNOGIndexTerm: COG2103
eggNOGDescriptionValue:
  Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate


eggNOGIndexTerm: COG3080
eggNOGDescriptionValue:
  Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane (By similarity)


eggNOGIndexTerm: ENOG410XZIG
eggNOGDescriptionValue:
  Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B (By similarity)


eggNOGIndexTerm: ENOG41122G1
eggNOGDescriptionValue:
  Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain


eggNOGIndexTerm: ENOG410YCNJ
eggNOGDescriptionValue:
  Component of a RSP5 ubiquitin ligase complex which specifies polyubiquitination and intracellular trafficking of the general amino acid permease GAP1 as well as other permeases such as PMA1. The RSP5-BUL1 2 complex is also necessary for the heat- shock element (HSE)-mediated gene expression, nitrogen starvation GLN3-dependent transcription and pressure-induced differential regulation of the 2 tryptophan permeases TAT1 and TAT2


eggNOGIndexTerm: COG0352
eggNOGDescriptionValue:
  Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity)


eggNOGIndexTerm: COG0353
eggNOGDescriptionValue:
  May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity)


eggNOGIndexTerm: COG0350
eggNOGDescriptionValue:
  Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity)


eggNOGIndexTerm: COG0354
eggNOGDescriptionValue:
  Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity)


eggNOGIndexTerm: COG1234
eggNOGDescriptionValue:
  Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity)


eggNOGIndexTerm: ENOG41101KD
eggNOGDescriptionValue:
  The biological conversion of cellulose to glucose generally requires three types of hydrolytic enzymes (1) Endoglucanases which cut internal beta-1,4-glucosidic bonds


eggNOGIndexTerm: ENOG4112345
eggNOGDescriptionValue:
  Modulates the activity of the EnvZ OmpR two-component regulatory system, probably by directly modulating EnvZ enzymatic activity and increasing stability of phosphorylated OmpR (By similarity)


eggNOGIndexTerm: ENOG4112808
eggNOGDescriptionValue:
  Required for bacteriochlorophyll biosynthesis. Directly involved in the assembly of both the B875 and B800-850 pigment- protein complexes (By similarity)


eggNOGIndexTerm: COG0213
eggNOGDescriptionValue:
  The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis (By similarity)


eggNOGIndexTerm: ENOG4111X7W
eggNOGDescriptionValue:
  Forms a complex with the serine threonine kinase MEC1 which activates checkpoint signaling upon genotoxic stresses. The MEC1-LCD1 complex is recruited to DNA lesions in order to initiates the DNA repair by homologous recombination. Required for cell growth and meiotic recombination (By similarity)


eggNOGIndexTerm: COG4559
eggNOGDescriptionValue:
  Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity)


eggNOGIndexTerm: COG3186
eggNOGDescriptionValue:
  oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen


eggNOGIndexTerm: ENOG410XR2D
eggNOGDescriptionValue:
  Larval storage protein (LSP) which may serve as a store of amino acids for synthesis of adult proteins


eggNOGIndexTerm: ENOG41128I6
eggNOGDescriptionValue:
  Regulatory subunit of the slx1-slx4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA (By similarity)


eggNOGIndexTerm: COG5098
eggNOGDescriptionValue:
  Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases (By similarity)


eggNOGIndexTerm: COG5096
eggNOGDescriptionValue:
  The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non- clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins


eggNOGIndexTerm: COG5092
eggNOGDescriptionValue:
  Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins (By similarity)


eggNOGIndexTerm: ENOG411222S
eggNOGDescriptionValue:
  Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity)


eggNOGIndexTerm: ENOG410YEF2
eggNOGDescriptionValue:
  it is also involved in inducing stable DNA replication during SOS response. It forms, in concert with DnaB protein and other prepriming proteins DnaC, N, N', N'' a prepriming protein complex on the specific site of the template DNA recognized by protein N' (By similarity)


eggNOGIndexTerm: COG3109
eggNOGDescriptionValue:
  may be a structural element that influences the osmotic activation of ProP at a post-translational level (By similarity)


eggNOGIndexTerm: ENOG4111MFU
eggNOGDescriptionValue:
  N-acyltransferase required for nodulation. Acts in the production of a small, heat-stable compound (Nod) that stimulates mitosis in various plant protoplasts (By similarity)


eggNOGIndexTerm: COG0632
eggNOGDescriptionValue:
  The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity)


eggNOGIndexTerm: ENOG41120CC
eggNOGDescriptionValue:
  component of the regulatory network controlling carbon source utilization through ubiquitination and deubiquitination involving creA, creB, creC, creD and acrB. Involved in resistance to acriflavine, and required for normal growth on a range of sole carbon sources, including fructose, cellobiose, raffinose, and starch, and reduced utilization of amino acids, including GABA and beta-alanine, as sole carbon and nitrogen sources


eggNOGIndexTerm: ENOG4112CB6
eggNOGDescriptionValue:
  RNA-binding protein that binds specific mRNAs including the ASH1 mRNA, coding for a repressor of the HO endonuclease. Part of the mRNA localization machinery that restricts accumulation of certain proteins to the bud and in the daughter cell. Required for the delivery of cortical endoplasmic reticulum into the emerging bud (By similarity)


eggNOGIndexTerm: ENOG410ZAFR
eggNOGDescriptionValue:
  Ribonuclease that specifically degrades pre-mRNAs with a defective 5' end cap and is part of a pre-mRNA capping quality control. Has decapping and pyrophosphohydrolase activities. Has decapping activity toward incomplete 5' end cap mRNAs such as unmethylated 5' end-capped RNA to release GpppN and 5' end monophosphate RNA. Also possesses RNA 5'-pyrophosphohydrolase activity by hydrolyzing the 5' end triphosphate to release pyrophosphates


eggNOGIndexTerm: ENOG410XT9P
eggNOGDescriptionValue:
  Catalyzes the synthesis of Und-PP-GlcNAc-ManNAcA-Fuc4NAc (Lipid III), the third lipid-linked intermediate involved in ECA synthesis (By similarity)


eggNOGIndexTerm: ENOG4112BXP
eggNOGDescriptionValue:
  Required for normal formation of eisosomes, large cytoplasmic protein assemblies that localize to specialized domains on plasma membrane and mark the site of endocytosis (By similarity)


eggNOGIndexTerm: ENOG411151X
eggNOGDescriptionValue:
  Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells


eggNOGIndexTerm: ENOG410ZV5T
eggNOGDescriptionValue:
  Transcription factor. Interacts specifically with the W box (5'-(T)TGAC CT -3'), a frequently occurring elicitor- responsive cis-acting element (By similarity)


eggNOGIndexTerm: COG1074
eggNOGDescriptionValue:
  The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation


eggNOGIndexTerm: ENOG410ZY1E
eggNOGDescriptionValue:
  Antenna complexes are light-harvesting systems, which transfer the excitation energy to the reaction centers


eggNOGIndexTerm: ENOG4111BEG
eggNOGDescriptionValue:
  Receptor that may play a role in the perception of bitterness and is gustducin-linked. May play a role in sensing the chemical composition of the gastrointestinal content. The activity of this receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation and lead to the gating of TRPM5


eggNOGIndexTerm: COG1162
eggNOGDescriptionValue:
  May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity)


eggNOGIndexTerm: COG1165
eggNOGDescriptionValue:
  Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity)


eggNOGIndexTerm: COG0118
eggNOGDescriptionValue:
  IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The hisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to hisF for the synthesis of IGP and AICAR (By similarity)


eggNOGIndexTerm: COG0119
eggNOGDescriptionValue:
  Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity)


eggNOGIndexTerm: COG0112
eggNOGDescriptionValue:
  Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity)


eggNOGIndexTerm: COG0116
eggNOGDescriptionValue:
  Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity)


eggNOGIndexTerm: COG0117
eggNOGDescriptionValue:
  Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity)


eggNOGIndexTerm: COG5406
eggNOGDescriptionValue:
  Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II


eggNOGIndexTerm: ENOG410Y41W
eggNOGDescriptionValue:
  involved in mitochondrial DNA replication and recombination. Releases dinucleotides as main products of catalysis. Has the capacity to slide across 5'double-stranded DNA or 5'RNA sequences and resumes cutting two nucleotides downstream of the double-stranded-to- single-stranded junction or RNA-to-DNA junction, respectively (By similarity)


eggNOGIndexTerm: ENOG4111I0Z
eggNOGDescriptionValue:
  Involved in ubiquitin-mediated protein degradation. Regulatory factor in the ubiquitin proteasome pathway that controls the turnover of proteasome substrates. Targets proteasomes to the nucleus and facilitates the degradation of nuclear proteins (By similarity)


eggNOGIndexTerm: ENOG4111BRE
eggNOGDescriptionValue:
  function. Its presence in a non-photosynthetic plant (Epifagus virginiana) and experiments in tobacco indicate that it has an essential function which is probably not related to photosynthesis (By similarity)


eggNOGIndexTerm: ENOG4111P54
eggNOGDescriptionValue:
  The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane (By similarity)


eggNOGIndexTerm: ENOG4111HG8
eggNOGDescriptionValue:
  Autophagy-specific protein that functions in response to autophagy-inducing signals as a scaffold to recruit other ATG proteins to organize pre-autophagosomal structure (PAS) formation. Modulates the timing and magnitude of the autophagy response, such as the size of the sequestering vesicles. Plays particularly a role in pexophagy and nucleophagy (By similarity)


eggNOGIndexTerm: ENOG410YNSE
eggNOGDescriptionValue:
  Component of the spindle pole body (SPB) required for the proper execution of spindle pole body (SPB) duplication. Potential role in cross-linking filaments or anchoring other molecules. It is essential for growth (By similarity)


eggNOGIndexTerm: ENOG4110MT1
eggNOGDescriptionValue:
  Involved in transvection phenomena ( synapsis-dependent gene expression), where the synaptic pairing of chromosomes carrying genes with which zeste interacts influences the expression of these genes. Zeste binds to DNA and stimulates transcription from a nearby promoter


eggNOGIndexTerm: ENOG410Y1SY
eggNOGDescriptionValue:
  Catalyzes the hydrolysis of inorganic polyphosphate (poly P) chains of many hundreds of phosphate residues into shorter lengths (By similarity)


eggNOGIndexTerm: ENOG4111YYW
eggNOGDescriptionValue:
  Toxic component of a toxin-antitoxin (TA) module. An mRNA interferase which has been reported to be translation- independent (PubMed 19690171, PubMed 19943910) and translation- dependent (PubMed 20041169). Cleavage has been reported to occur on either side of G in the sequence GCU (PubMed 19690171) but also after C in GC(A U) sequences (PubMed 19943910). There are only 14 genes in E.coli W3110 (and probably also MG1655) that do not have a GCU sequence and thus are resistant to the mRNA interferase activity. Overexpression causes cessation of cell growth and inhibits cell proliferation via inhibition of translation as well as increasing persister cell formation


eggNOGIndexTerm: ENOG4111FNB
eggNOGDescriptionValue:
  negative regulation of canonical Wnt receptor signaling pathway involved in cardiac muscle cell fate commitment


eggNOGIndexTerm: ENOG41117Z8
eggNOGDescriptionValue:
  component of the GPI-GlcNAc transferase (GPI- GnT) complex in the endoplasmic reticulum, a complex that catalyzes transfer of GlcNAc from UDP-GlcNAc to an acceptor phosphatidylinositol, the first step in the production of GPI- anchors for cell surface proteins


eggNOGIndexTerm: ENOG410Y9IE
eggNOGDescriptionValue:
  Required for the post-translational delivery of tail- anchored (TA) proteins to the endoplasmic reticulum. Together with GET1, acts as a membrane receptor for soluble GET3, which recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. The GET complex cooperates with the HDEL receptor ERD2 to mediate the ATP-dependent retrieval of resident ER proteins that contain a C-terminal H-D-E-L retention signal from the Golgi to the ER


eggNOGIndexTerm: ENOG410Y4BP
eggNOGDescriptionValue:
  Activates the ATG1 kinase in a nutritional condition dependent manner through the TOR pathway, leading to autophagy. Also invoved in cytoplasm to vacuole transport (Cvt) and more specifically in Cvt vesicle formation. Seems to play a role in the switching machinery regulating the conversion between the Cvt pathway and autophagy. Finally, ATG13 is also required for glycogen storage during stationary phase (By similarity)


eggNOGIndexTerm: ENOG410ZIU6
eggNOGDescriptionValue:
  phage protein Ypo2115 SWALL Q8ZEP5 (EMBL AJ414151) (135 aa) fasta scores E() 5.8e-10, 34.58 id in 133 aa, and to Rhizobium loti


eggNOGIndexTerm: ENOG410XSMB
eggNOGDescriptionValue:
  Participates in the degradation of poly-3- hydroxybutyrate (PHB). It works downstream of poly(3- hydroxybutyrate) depolymerase, hydrolyzing D(-)-3-hydroxybutyrate oligomers of various length (3HB-oligomers) into 3HB-monomers (By similarity)


eggNOGIndexTerm: COG0317
eggNOGDescriptionValue:
  In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity)


eggNOGIndexTerm: COG0315
eggNOGDescriptionValue:
  Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity)


eggNOGIndexTerm: COG0310
eggNOGDescriptionValue:
  Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import (By similarity)


eggNOGIndexTerm: COG0311
eggNOGDescriptionValue:
  Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity)


eggNOGIndexTerm: ENOG41102EM
eggNOGDescriptionValue:
  Catalyzes the two-electron reduction of the C2 and C3(1) diene system of 15,16-dihydrobiliverdin (By similarity)


eggNOGIndexTerm: ENOG410XPTE
eggNOGDescriptionValue:
  Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine (By similarity)


eggNOGIndexTerm: COG0571
eggNOGDescriptionValue:
  Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity)


eggNOGIndexTerm: COG0245
eggNOGDescriptionValue:
  Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity)


eggNOGIndexTerm: COG2046
eggNOGDescriptionValue:
  Catalyzes the first intracellular reaction of sulfate assimilation, forming adenosine-5'-phosphosulfate (APS) from inorganic sulfate and ATP. Plays an important role in sulfate activation as a component of the biosynthesis pathway of sulfur- containing amino acids (By similarity)


eggNOGIndexTerm: ENOG41123WD
eggNOGDescriptionValue:
  electron donor, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory and or the photosynthetic chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation, and thus conserves the redox energy in a proton gradient. Cyanobacterial NDH-1 also plays a role in inorganic carbon- concentration (By similarity)


eggNOGIndexTerm: ENOG4111VC3
eggNOGDescriptionValue:
  transcription activated by CRP (cyclic AMP receptor protein), a global transcription factor involved in regulation of metabolism in enteric bacteria


eggNOGIndexTerm: ENOG411063V
eggNOGDescriptionValue:
  BEST Arabidopsis thaliana protein match is EDA32 (embryo sac development arrest 32) (TAIR AT3G62210.1)


eggNOGIndexTerm: COG0238
eggNOGDescriptionValue:
  Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity)


eggNOGIndexTerm: COG0237
eggNOGDescriptionValue:
  Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity)


eggNOGIndexTerm: COG0231
eggNOGDescriptionValue:
  Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity)


eggNOGIndexTerm: COG0233
eggNOGDescriptionValue:
  Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity)


eggNOGIndexTerm: ENOG410Z2VB
eggNOGDescriptionValue:
  Involved in spore and ascus formation. Required for the efficient assembly of the precursors of the prospore membrane to a continuous prospore membrane (By similarity)


eggNOGIndexTerm: ENOG4111NXJ
eggNOGDescriptionValue:
  Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. Active directional transport is assured by both, a Phe-Gly (FG) repeat affinity gradient for these transport factors across the NPC and a transport cofactor concentration gradient across the nuclear envelope (GSP1 and GSP2 GTPases associated predominantly with GTP in the nucleus, with GDP in the cytoplasm)


eggNOGIndexTerm: COG2609
eggNOGDescriptionValue:
  Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity)


eggNOGIndexTerm: COG2603
eggNOGDescriptionValue:
  Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA (By similarity)


eggNOGIndexTerm: COG0482
eggNOGDescriptionValue:
  Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity)


eggNOGIndexTerm: COG1871
eggNOGDescriptionValue:
  Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis (By similarity)


eggNOGIndexTerm: ENOG4111F6M
eggNOGDescriptionValue:
  Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II- dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex


eggNOGIndexTerm: COG3331
eggNOGDescriptionValue:
  Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation (By similarity)


eggNOGIndexTerm: COG4477
eggNOGDescriptionValue:
  modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization (By similarity)


eggNOGIndexTerm: COG0621
eggNOGDescriptionValue:
  Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity)


eggNOGIndexTerm: COG1903
eggNOGDescriptionValue:
  May catalyze the methylation of C-1 in cobalt-precorrin- 5 and the subsequent extrusion of acetic acid from the resulting intermediate to form cobalt-precorrin-6A (By similarity)


eggNOGIndexTerm: ENOG41120B0
eggNOGDescriptionValue:
  Required for the post-translational delivery of tail- anchored (TA) proteins to the endoplasmic reticulum. Acts as a membrane receptor for soluble get3, which recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol (By similarity)


eggNOGIndexTerm: ENOG4112BTC
eggNOGDescriptionValue:
  Involved in nonsense-mediated mRNA decay (NMD) by acting as a bridge between the mRNA decapping complex and the NMD machinery. May act by targeting the NMD machinery to the P-body and recruiting the decapping machinery to aberrant mRNAs. Required for upf1 rent1 localization to the P-body. Also acts as a nuclear receptor coactivator


eggNOGIndexTerm: ENOG4112BTV
eggNOGDescriptionValue:
  Interacts with MUS81 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'- flap structures, D-loops, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication fork intermediates. May be required in meiosis for the repair of meiosis-specific double strand breaks subsequent to single-end invasion (SEI) (By similarity)


eggNOGIndexTerm: ENOG410YBSZ
eggNOGDescriptionValue:
  Catalyzes the transfer of a methyl group from dimethylamine to the corrinoid cofactor of MtbC (By similarity)


eggNOGIndexTerm: ENOG410XXA6
eggNOGDescriptionValue:
  Sperm surface zona pellucida binding protein. Helps to bind spermatozoa to the zona pellucida with high affinity. Might function in binding zona pellucida and carbohydrates (By similarity)


eggNOGIndexTerm: ENOG410YS5X
eggNOGDescriptionValue:
  Component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. The KaiABC complex may act as a promoter-nonspecific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction. In the complex, it enhances the phosphorylation status of KaiC. In contrast, the presence of KaiB in the complex decreases the phosphorylation status of KaiC, suggesting that KaiB acts by antagonizing the interaction between KaiA and KaiC. A KaiA dimer is sufficient to enhance KaiC hexamer phosphorylation


eggNOGIndexTerm: ENOG41119U5
eggNOGDescriptionValue:
  Component of the COP9 signalosome (CSN) complex that acts as an regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunit of SCF-type E3 ubiquitin-protein ligase complexes The CSN complex is involved in the regulation of the mating pheromone response. PCI8 may also be involved in transcriptional and translational control


eggNOGIndexTerm: ENOG410Z4KD
eggNOGDescriptionValue:
  Manganese-binding polypeptide with L-arginine metabolizing enzyme activity. Component of the core of photosystem II (By similarity)


eggNOGIndexTerm: ENOG4110R2G
eggNOGDescriptionValue:
  May function as part of a signaling pathway that acts to regulate the size of the body fat depot (By similarity)


eggNOGIndexTerm: ENOG41116TP
eggNOGDescriptionValue:
  May be involved in cell migration and or actin cytoskeleton organization. When expressed in keratinocytes, induces changes in cell morphology with transfected cells showing an elongated shape, numerous membrane protrusions, major reorganization of the actin cytoskeleton, increased motility and decreased cell adhesion. Required for normal lung cell proliferation and alveolus formation at birth. Induces platelet aggregation. Does not have any effect on folic acid or amino acid transport. Does not function as a water channel or as a regulator of aquaporin-type water channels


eggNOGIndexTerm: COG0154
eggNOGDescriptionValue:
  Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity)


eggNOGIndexTerm: COG0155
eggNOGDescriptionValue:
  Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity)


eggNOGIndexTerm: COG0153
eggNOGDescriptionValue:
  Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity)


eggNOGIndexTerm: COG0159
eggNOGDescriptionValue:
  The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity)


eggNOGIndexTerm: ENOG410XXV5
eggNOGDescriptionValue:
  Required for coenzyme pyrroloquinoline quinone (PQQ) biosynthesis. PQQ is probably formed by cross-linking a specific glutamate to a specific tyrosine residue and excising these residues from the peptide (By similarity)


eggNOGIndexTerm: ENOG410XPYC
eggNOGDescriptionValue:
  ATP-binding RNA helicase involved in 40S ribosomal subunit biogenesis and is required for the normal formation of 18S rRNAs through pre-rRNA processing at A0, A1 and A2 sites. Required for vegetative growth (By similarity)


eggNOGIndexTerm: COG1623
eggNOGDescriptionValue:
  Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions (By similarity)


eggNOGIndexTerm: COG1622
eggNOGDescriptionValue:
  Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B) (By similarity)


eggNOGIndexTerm: COG0030
eggNOGDescriptionValue:
  Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity)


eggNOGIndexTerm: COG0037
eggNOGDescriptionValue:
  Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity)


eggNOGIndexTerm: COG0035
eggNOGDescriptionValue:
  Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity)


eggNOGIndexTerm: ENOG41122QJ
eggNOGDescriptionValue:
  Stabilizes the interaction between PsaC and the PSI core, assists the docking of the ferredoxin to PSI and interacts with ferredoxin-NADP oxidoreductase (By similarity)


eggNOGIndexTerm: COG0027
eggNOGDescriptionValue:
  Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR


eggNOGIndexTerm: ENOG410XYAR
eggNOGDescriptionValue:
  RuBisCO catalyzes two reactions the carboxylation of D- ribulose 1,5-bisphosphate, the primary event in carbon dioxide fixation, as well as the oxidative fragmentation of the pentose substrate. Both reactions occur simultaneously and in competition at the same active site (By similarity)


eggNOGIndexTerm: COG3770
eggNOGDescriptionValue:
  Involved in the removal of murein from the sacculus. May also facilitate integration of nascent murein strands into the sacculus by cleaving the peptide bonds between neighboring strands in mature murein (By similarity)


eggNOGIndexTerm: ENOG410ZKFF
eggNOGDescriptionValue:
  Alpha-galactosidase. Removes both branched alpha-1,3- linked galactose residues of blood group B antigens and linear alpha-1,3-linked galactose structures


eggNOGIndexTerm: ENOG41127W0
eggNOGDescriptionValue:
  Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity)


eggNOGIndexTerm: ENOG410XPPS
eggNOGDescriptionValue:
  Catalyzes the non-heme iron(II)-dependent oxidative cleavage of 2,3-dihydroxyphenylpropionic acid and 2,3- dihydroxicinnamic acid into 2-hydroxy-6-ketononadienedioate and 2- hydroxy-6-ketononatrienedioate, respectively (By similarity)


eggNOGIndexTerm: COG0536
eggNOGDescriptionValue:
  An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control


eggNOGIndexTerm: COG0532
eggNOGDescriptionValue:
  One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity)


eggNOGIndexTerm: COG0539
eggNOGDescriptionValue:
  thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity)


eggNOGIndexTerm: ENOG410Z4MY
eggNOGDescriptionValue:
  adapter protein and signal transducer that links members of the tumor necrosis factor receptor family to different signaling pathways by association with the receptor cytoplasmic domain and kinases (By similarity)


eggNOGIndexTerm: COG2209
eggNOGDescriptionValue:
  NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity)


eggNOGIndexTerm: ENOG411136R
eggNOGDescriptionValue:
  This is a non-secretory ribonuclease. It is a pyrimidine specific nuclease with a slight preference for U. Cytotoxin and helminthotoxin. Possesses a wide variety of biological activities


eggNOGIndexTerm: ENOG410Z6ST
eggNOGDescriptionValue:
  This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand (By similarity)


eggNOGIndexTerm: ENOG410Y6V4
eggNOGDescriptionValue:
  Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2 3 complex


eggNOGIndexTerm: ENOG41101XF
eggNOGDescriptionValue:
  Bifunctional protein that converts poly(beta-D- mannuronate) to alpha-L-guluronate and that is also part of a periplasmic protein complex that serves as a scaffold that leads the newly formed alginate polymer through the periplasmic space to the outer membrane secretin AlgE


eggNOGIndexTerm: ENOG410XPER
eggNOGDescriptionValue:
  Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. The Mediator complex, having a compact conformation in its free form, is recruited to promoters by direct interactions with regulatory proteins and serves for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Involved in the repression of phenylpropanoid biosynthesis. May compete with MED33B for common binding partners or for occupancy in Mediator


eggNOGIndexTerm: ENOG410ZMCR
eggNOGDescriptionValue:
  Involved in the metabolism of ADP-ribose 1',2'-cyclic phosphate which is produced as a consequence of tRNA splicing (By similarity)


eggNOGIndexTerm: ENOG4111GH8
eggNOGDescriptionValue:
  Catalyzes the oxidative ring opening of 3- hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate (By similarity)


eggNOGIndexTerm: COG0275
eggNOGDescriptionValue:
  Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity)


eggNOGIndexTerm: COG0274
eggNOGDescriptionValue:
  Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity)


eggNOGIndexTerm: COG3417
eggNOGDescriptionValue:
  Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b) (By similarity)


eggNOGIndexTerm: COG0459
eggNOGDescriptionValue:
  Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity)


eggNOGIndexTerm: ENOG4111WGP
eggNOGDescriptionValue:
  Represses biofilm formation in M9C glu and LB glu media but not in M9C and LB media. Seems to act as a global regulator of several genes involved in catabolite repression and stress response and regulation of the uptake and export of signaling pathways. Could be involved the regulation of indole as well as uptake and export of AI-2 through a cAMP-dependent pathway


eggNOGIndexTerm: ENOG4111WGS
eggNOGDescriptionValue:
  Functions as component of the Arp2 3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks (By similarity)


eggNOGIndexTerm: ENOG4111Y56
eggNOGDescriptionValue:
  Reduces the permeability of the outer membrane to copper. Seems to be involved in the regulation of biofilm formation. May decrease biofilm formation by repressing cell-cell interaction and cell surface interaction


eggNOGIndexTerm: ENOG4111DVT
eggNOGDescriptionValue:
  PsaA and PsaB bind P700, the primary electron donor of photosystem I (PSI), as well as the electron acceptors A0, A1 and FX. PSI is a plastocyanin-ferredoxin oxidoreductase, converting photonic excitation into a charge separation, which transfers an electron from the donor P700 chlorophyll pair to the spectroscopically characterized acceptors A0, A1, FX, FA and FB in turn. Oxidized P700 is reduced on the lumenal side of the thylakoid membrane by plastocyanin


eggNOGIndexTerm: ENOG4111AY2
eggNOGDescriptionValue:
  Mating type proteins are sequence specific DNA-binding proteins that act as master switches in yeast differentiation by controlling gene expression in a cell type-specific fashion. Transcriptional


eggNOGIndexTerm: ENOG4111AYA
eggNOGDescriptionValue:
  Component of the cytoplasmic dynein which acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play an important role in the proper orientation of the mitotic spindle into the budding daughter cell yeast. Probably required for normal progression of the cell cycle


eggNOGIndexTerm: ENOG4110Z5V
eggNOGDescriptionValue:
  - Bric-a-Brac, Tramtrack, Broad Complex BTB domain with Meprin and TRAF Homology MATH domain, expressed


eggNOGIndexTerm: ENOG4112CNM
eggNOGDescriptionValue:
  Involved in nucleolar integrity and required for processing of the pre-rRNA for the 60S ribosome subunit (By similarity)


eggNOGIndexTerm: ENOG410XRPH
eggNOGDescriptionValue:
  During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS


eggNOGIndexTerm: COG1995
eggNOGDescriptionValue:
  Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity)


eggNOGIndexTerm: ENOG4111H82
eggNOGDescriptionValue:
  Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity)


eggNOGIndexTerm: COG4623
eggNOGDescriptionValue:
  Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella (By similarity)


eggNOGIndexTerm: ENOG4111VXN
eggNOGDescriptionValue:
  Forms a fork protection complex (FPC) with tof1 and which is required for chromosome segregation during meiosis and DNA damage repair. FPC coordinates leading and lagging strand synthesis and moves with the replication fork. FPC stabilizes replication forks in a configuration that is recognized by replication checkpoint sensors (By similarity)


eggNOGIndexTerm: ENOG4112DAV
eggNOGDescriptionValue:
  Stabilizes the atg5-atg12 conjugate which is necessary for autophagy. The atg5-atg12 atg16 complex is required for efficient promotion of ATG8-conjugation to phosphatidylethanolamine and ATG8 localization to the pre- autophagosomal structure (PAS). Recruites also ATG3 to the PAS. Involved in endoplasmic reticulum-specific autophagic process and is essential for the survival of cells subjected to severe ER stress (By similarity)


eggNOGIndexTerm: ENOG410ZH2D
eggNOGDescriptionValue:
  A hormone that controls sex pheromone production in females and pheromone responsiveness in male. Also mediates visceral muscle contractile activity (myotropic activity)


eggNOGIndexTerm: ENOG4111PX3
eggNOGDescriptionValue:
  Functions as a nucleotide exchange factor (NEF) for Hsp70 chaperones which accelerates the release of ADP. Required for fully efficient Hsp70-mediated folding of proteins (By similarity)


eggNOGIndexTerm: ENOG41118N2
eggNOGDescriptionValue:
  In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the MD-2 TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Up-regulates cell surface molecules, including adhesion molecules (By similarity)


eggNOGIndexTerm: ENOG41118N4
eggNOGDescriptionValue:
  Required for cytoplasm to vacuole transport (Cvt) vesicle formation and efficient autophagy. Plays a role in ATG protein retrieval from the pre-autophagosomal structure (PAS) and is especially required for autophagy-dependent cycling of ATG9. Plays also a role in regulation of filamentous growth (By similarity)


eggNOGIndexTerm: ENOG41118N7
eggNOGDescriptionValue:
  of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA


eggNOGIndexTerm: ENOG41118NE
eggNOGDescriptionValue:
  Involved in the export of PMA1, possibly through the monitoring or assisting of PMA1 folding and acquisition of competence to enter vesicles (By similarity)


eggNOGIndexTerm: ENOG410Y6QV
eggNOGDescriptionValue:
  Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex (E2)


eggNOGIndexTerm: ENOG410Y49V
eggNOGDescriptionValue:
  Multifunctional regulator of mitochondrial architecture and protein biogenesis. May act in concert with ATP synthase dimers to generate inner membrane structure and consequently normal mitochondrial morphology. Plays a role in keeping cristae membranes connected to the inner boundary membrane. Promotes protein import via the mitochondrial intermembrane space assembly (MIA) pathway (By similarity)


eggNOGIndexTerm: ENOG4111QZF
eggNOGDescriptionValue:
  Final heterodimeric neurohormone released at the end of the molting cycle, involved in the sclerotization (tanning) of the insect cuticle, melanization and wing spreading


eggNOGIndexTerm: ENOG410XXRN
eggNOGDescriptionValue:
  Component of the mitochondrial inner membrane i-AAA protease complex required for mitochondrial inner membrane protein turnover


eggNOGIndexTerm: ENOG4111UCP
eggNOGDescriptionValue:
  Virulence regulator that has both architectural and regulatory roles. Impacts cell wall functions and pathogenesis through regulation of multiple genes, including the espACD operon, which is a key ESX-1 component. Influences target gene expression positively or negatively, depending on its binding position relative to the genes it controls. Acts by binding directly to the DNA. May play a central role in regulating virulence gene expression


eggNOGIndexTerm: ENOG4110ZMY
eggNOGDescriptionValue:
  protein-kinase, interferon-inducible double stranded RNA dependent inhibitor, repressor of (P58 repressor)


eggNOGIndexTerm: ENOG4112D26
eggNOGDescriptionValue:
  Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues. This protein includes tyrosine phosphatase and GTPase activating protein (GAP) activities. After bacterial internalization, GAP mediates the reversal of the cytoskeletal changes induced by SopE. This function is independent of its tyrosine phosphatase activity, which remains unclear


eggNOGIndexTerm: ENOG41128AE
eggNOGDescriptionValue:
  Regulator of type 1 phosphatases which maintains protein phosphatase activity under strict control (By similarity)


eggNOGIndexTerm: ENOG4111CMR
eggNOGDescriptionValue:
  Involved in pseudohyphal growth, cell wall metabolism and required for the separation of the mother and daughter cells


eggNOGIndexTerm: ENOG4111HP4
eggNOGDescriptionValue:
  Required for the maintenance of the structure of the mitochondrial inner membrane. Involved in mitochondrial morphology. Causes growth arrest when highly overexpressed (By similarity)


eggNOGIndexTerm: COG5226
eggNOGDescriptionValue:
  Second step of mRNA capping. Transfer of the GMP moiety of GTP to the 5'-end of RNA via an enzyme-GMP covalent reaction intermediate (By similarity)


eggNOGIndexTerm: COG4862
eggNOGDescriptionValue:
  Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis


eggNOGIndexTerm: ENOG41102F4
eggNOGDescriptionValue:
  DNA-binding protein involved in single-strand DNA break repair, double-strand DNA break repair and base excision repair. Resolves abortive DNA ligation intermediates formed either at base excision sites, or when DNA ligases attempt to repair non- ligatable breaks induced by reactive oxygen species. Catalyzes the release of adenylate groups covalently linked to 5'-phosphate termini, resulting in the production of 5'-phosphate termini that can be efficiently rejoined


eggNOGIndexTerm: ENOG4111Q7E
eggNOGDescriptionValue:
  Involved in the import of light-harvesting complex proteins (LHCP) and subsequent routing of these proteins to the chloroplast signal recognition particle (SRP) pathway


eggNOGIndexTerm: COG0190
eggNOGDescriptionValue:
  Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity)


eggNOGIndexTerm: ENOG4111STF
eggNOGDescriptionValue:
  May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity


eggNOGIndexTerm: ENOG410ZSG2
eggNOGDescriptionValue:
  EXPRESSED DURING L mature pollen stage, M germinated pollen stage, 4 anthesis, C globular stage, petal differentiation and expansion stage


eggNOGIndexTerm: ENOG4111IRG
eggNOGDescriptionValue:
  Has a dual role in the assembly of mitochondrial ATPase. Acts as a protease that removes N-terminal residues of mitochondrial ATPase CF(0) subunit 6 at the intermembrane space side. Also involved in the correct assembly of the membrane- embedded ATPase CF(0) particle, probably mediating association of subunit 6 with the subunit 9 ring (By similarity)


eggNOGIndexTerm: COG0391
eggNOGDescriptionValue:
  Catalyzes the transfer of the 2-phospholactate moiety from lactyl (2) diphospho-(5')guanosine (LPPG) to 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) with the formation of the L- lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5- deazariboflavin (F420-0) and GMP (By similarity)


eggNOGIndexTerm: ENOG410Z9CT
eggNOGDescriptionValue:
  Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu- tRNA(Gln). Required for proper protein synthesis within the mitochondrion (By similarity)


eggNOGIndexTerm: COG1212
eggNOGDescriptionValue:
  Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity)


eggNOGIndexTerm: ENOG4111CXI
eggNOGDescriptionValue:
  Catalyzes the intermembrane transfer of phosphatidylglycerol and phosphatidylinositol (By similarity)


eggNOGIndexTerm: ENOG410ZIX1
eggNOGDescriptionValue:
  Regulatory subunit of the histone H2A phosphatase complex, which dephosphorylates H2AS128ph (gamma-H2A) that has been displaced from sites of DNA lesions in the double-stranded DNA break repair process. Dephosphorylation is necessary for efficient recovery from the DNA damage checkpoint


eggNOGIndexTerm: COG4263
eggNOGDescriptionValue:
  Nitrous-oxide reductase is part of a bacterial respiratory system which is activated under anaerobic conditions in the presence of nitrate or nitrous oxide (By similarity)


eggNOGIndexTerm: COG3010
eggNOGDescriptionValue:
  Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P) (By similarity)


eggNOGIndexTerm: ENOG41114MC
eggNOGDescriptionValue:
  Component of the spindle pole body (SPB) required for insertion of the nascent SPB into the nuclear envelope and for the proper execution of spindle pole body (SPB) duplication (By similarity)


eggNOGIndexTerm: COG0740
eggNOGDescriptionValue:
  Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity)


eggNOGIndexTerm: ENOG4110HYR
eggNOGDescriptionValue:
  A G protein-coupled receptor required for olfactory imprinting a requisite in ordorant response such as benzaldehyde and isoamylalcohol


eggNOGIndexTerm: COG1426
eggNOGDescriptionValue:
  Cytoskeletal protein that is involved in cell-shape control through regulation of the length of the long axis (By similarity)


eggNOGIndexTerm: COG1424
eggNOGDescriptionValue:
  Catalyzes the transformation of pimelate into pimeloyl- CoA with concomitant hydrolysis of ATP to AMP (By similarity)


eggNOGIndexTerm: COG4533
eggNOGDescriptionValue:
  Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity)


eggNOGIndexTerm: COG0419
eggNOGDescriptionValue:
  Involved in DNA double-strand break repair (DSBR). The Rad50 Mre11 complex possesses single-strand endonuclease activity and ATP-dependent double-strand-specific 3'-5' exonuclease activity. Rad50 provides an ATP-dependent control of Mre11 by unwinding and or repositioning DNA ends into the Mre11 active site (By similarity)


eggNOGIndexTerm: COG0413
eggNOGDescriptionValue:
  Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity)


eggNOGIndexTerm: COG0414
eggNOGDescriptionValue:
  Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity)


eggNOGIndexTerm: COG0416
eggNOGDescriptionValue:
  Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity)


eggNOGIndexTerm: COG0854
eggNOGDescriptionValue:
  Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity)


eggNOGIndexTerm: ENOG41121P7
eggNOGDescriptionValue:
  Gas vesicles are small, hollow, gas filled protein structures that are found in several microbial planktonic microorganisms. They allow the positioning of the organism at the favorable depth for growth (By similarity)


eggNOGIndexTerm: ENOG41104JR
eggNOGDescriptionValue:
  BEST Arabidopsis thaliana protein match is protein kinase family protein U-box domain-containing protein (TAIR AT2G45910.1)


eggNOGIndexTerm: ENOG410ZQK6
eggNOGDescriptionValue:
  Regulatory subunit of lactose synthase, changes the substrate specificity of galactosyltransferase in the mammary gland making glucose a good acceptor substrate for this enzyme. This enables LS to synthesize lactose, the major carbohydrate component of milk. In other tissues, galactosyltransferase transfers galactose onto the N-acetylglucosamine of the oligosaccharide chains in glycoproteins


eggNOGIndexTerm: ENOG4112CJ0
eggNOGDescriptionValue:
  BEST Arabidopsis thaliana protein match is PTAC18 (PLASTID TRANSCRIPTIONALLY ACTIVE 18) (TAIR AT2G32180.1)


eggNOGIndexTerm: ENOG410ZS8D
eggNOGDescriptionValue:
  Catalyzes the attachment of pyrrolysine to tRNA(Pyl). Pyrrolysine is a lysine derivative encoded by the termination codon UAG


eggNOGIndexTerm: COG2973
eggNOGDescriptionValue:
  This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region (By similarity)


eggNOGIndexTerm: COG1889
eggNOGDescriptionValue:
  Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA (By similarity)


eggNOGIndexTerm: COG1880
eggNOGDescriptionValue:
  Part of a complex that catalyzes the reversible cleavage of acetyl-CoA, allowing autotrophic growth from CO(2). Probably has a structural role in stabilizing the alpha-epsilon subcomponent of the ACDS complex by forming a structural link between the two alpha subunits (By similarity)


eggNOGIndexTerm: COG4123
eggNOGDescriptionValue:
  Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC) (By similarity)


eggNOGIndexTerm: ENOG410Z7SR
eggNOGDescriptionValue:
  This protein is involved in the determination of copy number in gene replication. It binds to the repA promoter thus inhibiting the synthesis of the mRNA for the initiator protein repA (By similarity)


eggNOGIndexTerm: COG1348
eggNOGDescriptionValue:
  The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex, which has 2 components the iron protein and the molybdenum-iron protein (By similarity)


eggNOGIndexTerm: ENOG410ZJCG
eggNOGDescriptionValue:
  Required for the post-translational delivery of tail- anchored (TA) proteins to the endoplasmic reticulum. Together with GET1, acts as a membrane receptor for soluble GET3, which recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. The GET complex cooperates with the HDEL receptor ERD2 to mediate the ATP-dependent retrieval of resident ER proteins that contain a C-terminal H-D-E-L retention signal from the Golgi to the ER (By similarity)


eggNOGIndexTerm: ENOG410XQA3
eggNOGDescriptionValue:
  Intercellular signal essential for a variety of patterning events during development (By similarity)


eggNOGIndexTerm: COG5123
eggNOGDescriptionValue:
  TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation (By similarity)


eggNOGIndexTerm: ENOG4111428
eggNOGDescriptionValue:
  Mitochondrial acyltransferase which transfers an acyl group to the N-terminus of glycine and glutamine, although much less efficiently. Can conjugate a multitude of substrates to form a variety of N-acylglycines, thereby detoxify xenobiotics, such as benzoic acid or salicylic acid, and endogenous organic acids, such as isovaleric acid


eggNOGIndexTerm: ENOG411208S
eggNOGDescriptionValue:
  Encodes a protein DOMINO1 that belongs to a plant-specific gene family sharing a common motif present in the tomato DEFECTIVE CHLOROPLASTS AND LEAVES (LeDCL) protein. DOMINO1 is located in the nucleus. Arabidopsis embryos carrying the domino1 mutation grow slowly in comparison with wild type embryos and reach only the globular stage at desiccation. The primary defect of the mutation at the cellular level is the large size of the nucleolus that can be observed soon after fertilization in the nuclei of both the embryo and the endosperm. DOMINO1 might have a role in ribosome biogenesis and in determining the rate of cell division


eggNOGIndexTerm: COG4063
eggNOGDescriptionValue:
  Part of a complex that catalyzes the formation of methyl-coenzyme M and tetrahydromethanopterin from coenzyme M and methyl-tetrahydromethanopterin. This is an energy-conserving, sodium-ion translocating step


eggNOGIndexTerm: ENOG41114P9
eggNOGDescriptionValue:
  May regulate endocytosis by recruiting RSP5 ubiquitin ligase activity to specific plasma membrane proteins in response to extracellular stimuli (By similarity)


eggNOGIndexTerm: ENOG4110K6I
eggNOGDescriptionValue:
  Transcriptional activator that binds the same DNA consensus sequence as p53. Has a role in normal development to ensure proper meiotic chromosome segregation. Promotes apoptosis under conditions of cellular and genotoxic stress in response to DNA damage, hypoxia, or starvation. However, not required for DNA repair in response to UV-C or to regulate cell-cycle progression. Required for induction of ced-13 in response to DNA damage. Regulates germline proliferation by activating phg-1


eggNOGIndexTerm: ENOG41114IV
eggNOGDescriptionValue:
  Component of the spindle pole body (SPB) required for the proper execution of spindle pole body (SPB) duplication. Links the central plaque component SPC42 to the inner plaque component SPC110 (By similarity)


eggNOGIndexTerm: ENOG4111D2K
eggNOGDescriptionValue:
  Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity)


eggNOGIndexTerm: ENOG411281Q
eggNOGDescriptionValue:
  Component of the EKC KEOPS complex which promotes both telomere uncapping and telomere elongation (By similarity). The complex is required for efficient recruitment of transcriptional coactivators (By similarity)


eggNOGIndexTerm: ENOG410Y29F
eggNOGDescriptionValue:
  Involved in the metabolism of ADP-ribose 1',2'-cyclic phosphate which is produced as a consequence of tRNA splicing


eggNOGIndexTerm: ENOG4111Z8I
eggNOGDescriptionValue:
  Involved both in the piRNA and miRNA metabolic processes. As a component of the meiotic nuage, plays a central role during oogenesis by repressing transposable elements and prevent their mobilization, which is essential for the germline integrity. Repression of transposable elements is mediated via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the repression of transposons. As a nuclear component, it is required for proper differentiation in the germline stem cell (GSC) lineage by repressing microRNA-7 (miR-7), thereby acting as an indirect regulator of bag-of-marbles (Bam). Acts by binding to the promoter of miR-7 gene and repressing its expression


eggNOGIndexTerm: COG2386
eggNOGDescriptionValue:
  Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity)


eggNOGIndexTerm: ENOG410XP3K
eggNOGDescriptionValue:
  Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein- mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for


eggNOGIndexTerm: COG2901
eggNOGDescriptionValue:
  Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters (By similarity)


eggNOGIndexTerm: COG1556
eggNOGDescriptionValue:
  Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source (By similarity)


eggNOGIndexTerm: COG2156
eggNOGDescriptionValue:
  One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity)


eggNOGIndexTerm: COG4229
eggNOGDescriptionValue:
  Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) (By similarity)


eggNOGIndexTerm: ENOG4111XG2
eggNOGDescriptionValue:
  Transfers sialic acid from the substrate CMP-sialic acid donor to the terminal beta-D-galactosyl-1,4-acetyl-beta-D- glucosamine on the lacto-N-neotetraose branch of the lipooligosaccharide


eggNOGIndexTerm: COG3055
eggNOGDescriptionValue:
  Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses (By similarity)


eggNOGIndexTerm: COG3057
eggNOGDescriptionValue:
  Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated (By similarity)


eggNOGIndexTerm: ENOG41122JF
eggNOGDescriptionValue:
  Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein- effector interaction


eggNOGIndexTerm: ENOG4111MJU
eggNOGDescriptionValue:
  Negative regulator of the mitotic exit network (MEN), required for multiple cell cycle checkpoints (By similarity). Required for daughter cell separation and chromosome stability (By similarity). Involved in copper sensitivity (By similarity)


eggNOGIndexTerm: ENOG4111T3E
eggNOGDescriptionValue:
  Component of the 90S pre-ribosome involved in the maturation of rRNAs. Required for early cleavages of the pre-RNAs in the 40S ribosomal subunit maturation pathway (By similarity)


eggNOGIndexTerm: ENOG4111T3Y
eggNOGDescriptionValue:
  DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity)


eggNOGIndexTerm: COG1209
eggNOGDescriptionValue:
  Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity)


eggNOGIndexTerm: COG1207
eggNOGDescriptionValue:
  Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity)


eggNOGIndexTerm: COG1206
eggNOGDescriptionValue:
  Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs (By similarity)


eggNOGIndexTerm: COG1521
eggNOGDescriptionValue:
  Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity)


eggNOGIndexTerm: ENOG410Z8MR
eggNOGDescriptionValue:
  Regulatory protein, which plays a central role in chromosome stability, in the p53 TP53 pathway, and DNA repair. Probably acts by blocking the action of key proteins. During the mitosis, it blocks Separase ESPL1 function, preventing the proteolysis of the cohesin complex and the subsequent segregation of the chromosomes. At the onset of anaphase, it is ubiquitinated, conducting to its destruction and to the liberation of ESPL1. Its function is however not limited to a blocking activity, since it is required to activate ESPL1. Negatively regulates the transcriptional activity and related apoptosis activity of


eggNOGIndexTerm: ENOG4112CJD
eggNOGDescriptionValue:
  Component of the RPD3 histone deacetylase complex RPD3C(L) responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events


eggNOGIndexTerm: ENOG4110NBM
eggNOGDescriptionValue:
  Acts as a component of the essential kinetochore- associated Ndc80 complex, which is required for chromosome segregation and spindle checkpoint activity during meiosis and mitosis. Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore. Participates in SAC signaling that responds specifically to disruptions in spindle microtubule dynamics


eggNOGIndexTerm: ENOG4110NBV
eggNOGDescriptionValue:
  Integral part of the sensory system that mediates food signaling, providing the neural basis for the regulation of food response


eggNOGIndexTerm: ENOG410Y7I5
eggNOGDescriptionValue:
  This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. This protein may mediate formation of the complex between cytochromes c and c1 (By similarity)


eggNOGIndexTerm: ENOG410XQKB
eggNOGDescriptionValue:
  Extracellular matrix serine protease that plays a role in layering of neurons in the cerebral cortex and cerebellum. Regulates microtubule function in neurons and neuronal migration. Affects migration of sympathetic preganglionic neurons in the spinal cord, where it seems to act as a barrier to neuronal migration. Enzymatic activity is important for the modulation of cell adhesion. Binding to the extracellular domains of lipoprotein receptors VLDLR and LRP8 APOER2 induces tyrosine phosphorylation of DAB1 and modulation of TAU phosphorylation


eggNOGIndexTerm: ENOG410ZGA9
eggNOGDescriptionValue:
  Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane (By similarity)


eggNOGIndexTerm: ENOG4110I0I
eggNOGDescriptionValue:
  FMRFamides and FMRFamide-like peptides are neuropeptides. AQTFVRF-amide inhibits the activity of dissected pharyngeal myogenic muscle system


eggNOGIndexTerm: ENOG410XQZC
eggNOGDescriptionValue:
  Sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (Semaphorin)


eggNOGIndexTerm: ENOG410XQZU
eggNOGDescriptionValue:
  A stabilizing protein that is part of the accessory SecA2 SecY2 system specifically required to export serine-rich repeat cell wall proteins usually encoded upstream in the same operon. Stabilizes the glycosylation activity of Gtf1 (By similarity)


eggNOGIndexTerm: ENOG4110KDU
eggNOGDescriptionValue:
  Participates in the inductive signaling pathway downstream of let-60 Ras and the RAF MAP kinase cascade to regulate specification and differentiation of many cell types. Positively regulates the fate of vulval precursor cells. Required for induction of the P12 and excretory duct cell fates. In males, it is also required for proper formation of spicules. Does not function in the signaling pathway that promotes exit from pachytene


eggNOGIndexTerm: COG2938
eggNOGDescriptionValue:
  the catalytic subunit of succinate dehydrogenase (SDH). SDH is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). In is unclear whether it participates in the chemistry of FAD attachment (enzymatic function) or acts as a chaperone that maintains


eggNOGIndexTerm: COG2935
eggNOGDescriptionValue:
  May conjugate Arg from its aminoacyl-tRNA to the N- termini of proteins containing an N-terminal aspartate or glutamate


eggNOGIndexTerm: ENOG410XVAT
eggNOGDescriptionValue:
  to Lactobacillus delbrueckii DNA binding protein SWALL Q8VN11 (EMBL AJ421486) (112 aa) fasta scores E() 0.0039, 31.81 id in 88 aa


eggNOGIndexTerm: ENOG410XVAY
eggNOGDescriptionValue:
  serine threonine protein kinase which may function redundantly with MPK1-independent branch of the PCK1 pathway


eggNOGIndexTerm: COG5636
eggNOGDescriptionValue:
  Component of the cytosolic iron-sulfur (Fe S) protein assembly machinery. Required for the maturation of extramitochondrial Fe S proteins (By similarity). Has anti- apoptotic effects in the cell. Involved in negative control of H(2)O(2)-induced cell death, probably by tethering the pro- apoptotic factor tah18 in the cytoplasm in the absence of oxidative stress (By similarity)


eggNOGIndexTerm: COG1304
eggNOGDescriptionValue:
  Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity)


eggNOGIndexTerm: COG1303
eggNOGDescriptionValue:
  Specifically catalyzes the AdoMet-dependent 2'-O-ribose methylation of cytidine at position 56 in tRNAs (By similarity)


eggNOGIndexTerm: COG0776
eggNOGDescriptionValue:
  This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity)


eggNOGIndexTerm: COG0771
eggNOGDescriptionValue:
  Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity)


eggNOGIndexTerm: ENOG410XQM6
eggNOGDescriptionValue:
  Forms a fork protection complex (FPC) with csm-3 and which is required for chromosome segregation during meiosis and DNA damage repair. FPC coordinates leading and lagging strand synthesis and moves with the replication fork. FPC stabilizes replication forks in a configuration that is recognized by replication checkpoint sensors


eggNOGIndexTerm: ENOG4111NF0
eggNOGDescriptionValue:
  as a sensor for the physiological iron status within the plant, and or might be involved in the transport of iron


eggNOGIndexTerm: ENOG410Y8VV
eggNOGDescriptionValue:
  RNA-binding protein involved in the specific removal of group I introns in mitochondrial encoded transcripts. Maintains the stability of the small subunit mitochondrial 15S rRNA and thus the expression of the mitochondrial genome


eggNOGIndexTerm: COG2813
eggNOGDescriptionValue:
  Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity)


eggNOGIndexTerm: COG1003
eggNOGDescriptionValue:
  The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor


eggNOGIndexTerm: ENOG410Y59N
eggNOGDescriptionValue:
  Cell surface-associated protein implicated in virulence. Promotes bacterial attachment exclusively to the gamma-chain of human fibrinogen. Induces formation of bacterial clumps


eggNOGIndexTerm: ENOG410ZYWS
eggNOGDescriptionValue:
  Involved in mRNA splicing. Helps to stabilize the U1 snRNP-5' splice site interaction (By similarity)


eggNOGIndexTerm: ENOG41129MZ
eggNOGDescriptionValue:
  Factor that stimulates resuscitation of dormant cells. Has peptidoglycan (PG) hydrolytic activity. Active in the pM concentration range. Has little to no effect on actively-growing cells. PG fragments could either directly activate the resuscitation pathway of dormant bacteria or serve as a substrate for endogenous Rpf, resulting in low molecular weight products with resuscitation activity


eggNOGIndexTerm: ENOG410Y1R8
eggNOGDescriptionValue:
  Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. The complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11A. RAD50 may be required to bind DNA ends and hold them in close proximity. NBN modulate the DNA damage signal sensing by recruiting PI3 PI4-kinase family members ATM, ATR, and probably DNA-PKcs to the DNA damage sites and activating their functions. It can also recruit MRE11 and RAD50 to the proximity of DSBs by an interaction with the histone H2AX. NBN also functions in telomere length maintenance by generating the 3' overhang which serves as a primer for telomerase dependent telomere elongation. NBN is a major player in the control of intra-S-phase checkpoint and there is some evidence that NBN is involved in G1 and G2 checkpoints. The roles of NBS1 MRN encompass DNA damage sensor, signal transducer, and effector, which enable cells to maintain DNA integrity and genomic stability. Forms a complex with RBBP8 to link DNA double-strand break sensing to resection


eggNOGIndexTerm: ENOG410Y1RN
eggNOGDescriptionValue:
  Antitoxin component of a toxin-antitoxin (TA) module. A labile antitoxin (half-life of 2.1 minutes) that inhibits the endonuclease activity of cognate toxin RnlA but not that of non- cognate toxin LsoA


eggNOGIndexTerm: ENOG4111IZT
eggNOGDescriptionValue:
  Required for normal levels of the cell wall 1,6-beta- glucan. Involved in a protein folding machinery chaperoning proteins acting in various physiological processes including cell wall synthesis and lysis of autophagic bodies


eggNOGIndexTerm: ENOG410YVTQ
eggNOGDescriptionValue:
  CONTAINS InterPro DOMAIN s Cyclin-like F-box (InterPro IPR001810), F-box associated (InterPro IPR006527), F-box associated type 1 (InterPro IPR017451)


eggNOGIndexTerm: COG1797
eggNOGDescriptionValue:
  Responsible for the amidation of carboxylic groups at position A and C of either cobyrinic acid or hydrogenobrynic acid. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity)


eggNOGIndexTerm: ENOG410XSPY
eggNOGDescriptionValue:
  Alpha-N-arabinofuranosidase involved in the degradation of arabinoxylan, a major component of plant hemicellulose. Able to hydrolyze 1,5-, 1,3- and 1,2-alpha-linkages not only in L- arabinofuranosyl oligosaccharides, but also in polysaccharides containing terminal non-reducing L-arabinofuranoses in side chains, like L-arabinan, arabinogalactan and arabinoxylan


eggNOGIndexTerm: ENOG410ZSW7
eggNOGDescriptionValue:
  Ensures the proper localization of the mRNA of the bicoid gene to the anterior regions of the oocyte thus playing a fundamental role in the establishment of the polarity of the oocyte. May bind the bcd mRNA


eggNOGIndexTerm: ENOG410ZSWV
eggNOGDescriptionValue:
  induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression


eggNOGIndexTerm: COG3095
eggNOGDescriptionValue:
  Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF (By similarity)


eggNOGIndexTerm: COG3096
eggNOGDescriptionValue:
  Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division (By similarity)


eggNOGIndexTerm: ENOG410XZVD
eggNOGDescriptionValue:
  NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain (By similarity)


eggNOGIndexTerm: ENOG4110SI0
eggNOGDescriptionValue:
  Participates in the formation of a gel matrix (sperm coagulum) entrapping the accessory gland secretions and ejaculated spermatozoa


eggNOGIndexTerm: ENOG410XQ1S
eggNOGDescriptionValue:
  helicase, member of the UBC2 RAD6 epistasis group. Functions with DNA repair protein RAD18 in error-free postreplication DNA repair. Involved in the maintenance of wild- type rates of instability of simple repetitive sequences such as poly(GT) repeats. Seems to be involved in maintaining a balance which acts in favor of error-prone non-homologous joining during DNA double-strand breaks repairs (By similarity)


eggNOGIndexTerm: ENOG410XQ1D
eggNOGDescriptionValue:
  Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules


eggNOGIndexTerm: ENOG410YHM8
eggNOGDescriptionValue:
  Catalyzes the addition of fucose in alpha 1-6 linkage to the first GlcNAc residue, next to the peptide chains in N-glycans (By similarity)


eggNOGIndexTerm: ENOG4111YCI
eggNOGDescriptionValue:
  Effector of VPS34 phosphatidylinositol 3-phosphate kinase signaling. Regulates the cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a role in ATG protein retrieval from the pre-autophagosomal structure (PAS) and is especially required for autophagy-dependent cycling of ATG9 (By similarity)


eggNOGIndexTerm: ENOG410Y0ED
eggNOGDescriptionValue:
  Required for correct translation termination and probably involved in regulation of hypoxic gene expression (By similarity)


eggNOGIndexTerm: ENOG411243Z
eggNOGDescriptionValue:
  Member of a perinuclear network that controls recombination at multiple loci to maintain genome stability. Required for rDNA repeat stability (By similarity)


eggNOGIndexTerm: COG2037
eggNOGDescriptionValue:
  Catalyzes the transfer of a formyl group from 5-formyl tetrahydromethanopterin (5-formyl-H(4)MPT) to methanofuran (MFR) so as to produce formylmethanofuran (formyl-MFR) and tetrahydromethanopterin (H(4)MPT)


eggNOGIndexTerm: COG2036
eggNOGDescriptionValue:
  Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling


eggNOGIndexTerm: COG2038
eggNOGDescriptionValue:
  Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity)


eggNOGIndexTerm: COG0499
eggNOGDescriptionValue:
  May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine (By similarity)


eggNOGIndexTerm: COG4569
eggNOGDescriptionValue:
  Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD( ) and coenzyme A. Is the final enzyme in the meta- cleavage pathway for the degradation of aromatic compounds (By similarity)


eggNOGIndexTerm: COG0014
eggNOGDescriptionValue:
  Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity)


eggNOGIndexTerm: ENOG410XNXE
eggNOGDescriptionValue:
  Initiates the rapid degradation of small, acid-soluble proteins during spore germination (By similarity)


eggNOGIndexTerm: ENOG411140J
eggNOGDescriptionValue:
  Seems to play a role in testicular function. May be a trophic hormone with a role in testicular descent in fetal life. Is a ligand for LGR8 receptor


eggNOGIndexTerm: COG1806
eggNOGDescriptionValue:
  Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity)


eggNOGIndexTerm: COG5405
eggNOGDescriptionValue:
  Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity)


eggNOGIndexTerm: ENOG410Y9PR
eggNOGDescriptionValue:
  Component of the mitochondrial RNase MRP (MtMRP), a ribonucleoprotein endoribonuclease involved in the cleaving RNA transcripts to generate primers for DNA replication in mitochondria. Absent in the nucleus-localized RNase MRP (NuMRP) (By similarity)


eggNOGIndexTerm: ENOG410XQIV
eggNOGDescriptionValue:
  Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase


eggNOGIndexTerm: ENOG410YNEJ
eggNOGDescriptionValue:
  Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase. Specifically demethylates 'Lys-4' (H3K4me) and 'Lys-36' (H3K36me) of histone H3, thereby playing a central role in histone code


eggNOGIndexTerm: ENOG410XX1R
eggNOGDescriptionValue:
  Component of the SWR1 complex which mediates the ATP- dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. Involved in chromosome stability


eggNOGIndexTerm: COG0620
eggNOGDescriptionValue:
  Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity)


eggNOGIndexTerm: ENOG410Y8R8
eggNOGDescriptionValue:
  Overexpression increases levels of unsaturated fatty acids and suppresses both the temperature-sensitive fabA6 mutation and cold-sensitive secG null mutation


eggNOGIndexTerm: ENOG410ZNHE
eggNOGDescriptionValue:
  Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly


eggNOGIndexTerm: ENOG410XRIZ
eggNOGDescriptionValue:
  Mitochondrial inner membrane magnesium transporter required for mitochondrial magnesium homeostasis. Modulates the conductance of the MRS2 channel. Involved in the splicing of mRNA group II introns in mitochondria by affecting mitochondrial magnesium concentrations, which are critical for group II intron splicing


eggNOGIndexTerm: ENOG411168X
eggNOGDescriptionValue:
  E2-like enzyme involved in autophagy and for the cytoplasm to vacuole transport (Cvt). Acts as an E2-like enzyme that catalyzes the conjugation of ATG12 to ATG5. ATG12 conjugation to ATG5 is required for autophagy. Likely serves as an ATG5- recognition molecule (By similarity)


eggNOGIndexTerm: COG1901
eggNOGDescriptionValue:
  Specifically catalyzes the N1-methylation of pseudouridine at position 54 (Psi54) in tRNAs (By similarity)


eggNOGIndexTerm: COG0109
eggNOGDescriptionValue:
  Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity)


eggNOGIndexTerm: COG0105
eggNOGDescriptionValue:
  Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity)


eggNOGIndexTerm: COG1043
eggNOGDescriptionValue:
  Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)


eggNOGIndexTerm: COG1044
eggNOGDescriptionValue:
  Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)


eggNOGIndexTerm: ENOG410ZMHJ
eggNOGDescriptionValue:
  Transcription factor required for protein utilization and degradation. Regulates transcription of major secreted proteases


eggNOGIndexTerm: ENOG410Y5EA
eggNOGDescriptionValue:
  by preventing premature dissociation of cohesin complex from centromeres after prophase, when most of cohesin complex dissociates from chromosomes arms


eggNOGIndexTerm: COG1195
eggNOGDescriptionValue:
  it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity)


eggNOGIndexTerm: COG1493
eggNOGDescriptionValue:
  Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity)


eggNOGIndexTerm: COG0127
eggNOGDescriptionValue:
  Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity)


eggNOGIndexTerm: ENOG410ZTNB
eggNOGDescriptionValue:
  Causes loosening and extension of plant cell walls by disrupting non-covalent bonding between cellulose microfibrils and matrix glucans. No enzymatic activity has been found (By similarity)


eggNOGIndexTerm: ENOG410ZUY6
eggNOGDescriptionValue:
  Hormone playing a key role in cardiovascular homeostasis through regulation of natriuresis, diuresis, and vasodilation. Also plays a role in female pregnancy by promoting trophoblast invasion and spiral artery remodeling in uterus. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3


eggNOGIndexTerm: COG0850
eggNOGDescriptionValue:
  Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity)


eggNOGIndexTerm: COG0853
eggNOGDescriptionValue:
  Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity)


eggNOGIndexTerm: COG0855
eggNOGDescriptionValue:
  Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity)


eggNOGIndexTerm: ENOG410YWND
eggNOGDescriptionValue:
  Cell wall protein that participates directly in adhesive cell-cell interactions during yeast flocculation, a reversible, asexual and Ca(2 )-dependent process in which cells adhere to form aggregates (flocs) consisting of thousands of cells. The lectin- like protein sticks out of the cell wall of flocculent cells and selectively binds mannose residues in the cell walls of adjacent cells


eggNOGIndexTerm: ENOG41122BQ
eggNOGDescriptionValue:
  Is required to sustain N(2)-dependent growth in the presence of low levels of carbon monoxide (CO). Probably acts by protecting the N(2) fixation ability of the nitrogenase complex, which is inactivated in the presence of CO


eggNOGIndexTerm: ENOG41114YI
eggNOGDescriptionValue:
  Chemosensory receptor that negatively regulates RAS MAPK signaling during vulva induction and the negative regulation of olfaction of volitile attractants. Required for the suppression of vulval induction in response to food starvation. Signaling acts through the GPA-5 G-alpha protein subunit


eggNOGIndexTerm: COG1798
eggNOGDescriptionValue:
  S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF- 2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis (By similarity)


eggNOGIndexTerm: COG1791
eggNOGDescriptionValue:
  Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity)


eggNOGIndexTerm: COG0363
eggNOGDescriptionValue:
  Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity)


eggNOGIndexTerm: COG0362
eggNOGDescriptionValue:
  Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity)


eggNOGIndexTerm: COG0361
eggNOGDescriptionValue:
  however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity)


eggNOGIndexTerm: COG0365
eggNOGDescriptionValue:
  Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity)


eggNOGIndexTerm: COG0369
eggNOGDescriptionValue:
  Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity)


eggNOGIndexTerm: COG3844
eggNOGDescriptionValue:
  Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively (By similarity)


eggNOGIndexTerm: COG3842
eggNOGDescriptionValue:
  Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)


eggNOGIndexTerm: ENOG410XPUZ
eggNOGDescriptionValue:
  Removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline (By similarity)


eggNOGIndexTerm: COG2717
eggNOGDescriptionValue:
  Is probably involved in the electron transfer between its heme and the molybdenum cofactor of the reductase catalytic subunit YedY (By similarity)


eggNOGIndexTerm: COG1281
eggNOGDescriptionValue:
  Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity)


eggNOGIndexTerm: ENOG4111MYC
eggNOGDescriptionValue:
  Mediates the binding, internalization, and catabolism of lipoprotein particles. It can serve as a ligand for the LDL (apo B E) receptor and for the specific apo-E receptor (chylomicron remnant) of hepatic tissues


eggNOGIndexTerm: ENOG41128D3
eggNOGDescriptionValue:
  Required for the cellularization of the syncytial blastoderm embryo. Involved in the localization of the actin filaments just prior to and during plasma membrane invagination. Sry-alpha together with nullo and bnk may provide auxiliary functions, by acting both to stabilize a large and dynamic microfilament structure and regulate its functions


eggNOGIndexTerm: COG0222
eggNOGDescriptionValue:
  Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity)


eggNOGIndexTerm: COG0224
eggNOGDescriptionValue:
  Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity)


eggNOGIndexTerm: COG0225
eggNOGDescriptionValue:
  Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity)


eggNOGIndexTerm: ENOG410Y0TR
eggNOGDescriptionValue:
  May be involved in N-glycosylation through its association with N-oligosaccharyl transferase (By similarity)


eggNOGIndexTerm: ENOG410YTX5
eggNOGDescriptionValue:
  Toxin that seems to act by forming pores in the membrane of the cell. Has a hemolytic and a leucotoxic activity (By similarity)


eggNOGIndexTerm: ENOG4111F7Y
eggNOGDescriptionValue:
  permease that is required for glycolipid anchoring of LTA. May facilitate the transport of diglucosyl- diacylglycerol (Glc2-DAG) from the inner to the outer leaflet of the cytoplasmic membrane, delivering Glc2-DAG as a substrate for LTA synthesis, thereby generating glycolipid-anchored LTA. Appears to play an important role in virulence


eggNOGIndexTerm: ENOG41121D9
eggNOGDescriptionValue:
  Transcription activator. Doesn't appear to bind to the consensus 5'-AACAAT-3' DNA binding site, but binds 5'-ATTGTT-3'. All of the sox17 proteins are required for embryonic endoderm development and gastrulation movements, and show some redundancy in function. In addition, the sox17 proteins have distinct but overlapping roles in later gut development. Acts downstream of vegt-signaling in endoderm differentiation to induce a range of endodermal genes both directly and indirectly. Also represses wnt- responsive genes to inhibit wnt beta-catenin-mediated signaling (By similarity)


eggNOGIndexTerm: COG1386
eggNOGDescriptionValue:
  Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity)


eggNOGIndexTerm: COG1385
eggNOGDescriptionValue:
  Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity)


eggNOGIndexTerm: COG4465
eggNOGDescriptionValue:
  DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor (By similarity)


eggNOGIndexTerm: ENOG410XQU0
eggNOGDescriptionValue:
  Scaffold protein that may play a role in cell adhesion, cell spreading and in the reorganization of the actin cytoskeleton. Plays a role in the regulation of cell proliferation. May act as a tumor suppressor


eggNOGIndexTerm: ENOG4111NNQ
eggNOGDescriptionValue:
  Component of the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria. The KaiABC complex may act as a promoter-non-specific transcription regulator that represses transcription, possibly by acting on the state of chromosome compaction. In the complex, it decreases the phosphorylation status of KaiC. It has no effect on KaiC by itself, but instead needs the presence of both KaiA and KaiC, suggesting that it acts by antagonizing the interaction between KaiA and KaiC (By similarity)


eggNOGIndexTerm: COG0809
eggNOGDescriptionValue:
  Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity)


eggNOGIndexTerm: ENOG410Y3KT
eggNOGDescriptionValue:
  Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling (By similarity)


eggNOGIndexTerm: ENOG410XRMA
eggNOGDescriptionValue:
  Essential component of the cytosolic iron-sulfur (Fe S) protein assembly machinery. Required for the maturation of extramitochondrial Fe S proteins (By similarity)


eggNOGIndexTerm: COG2890
eggNOGDescriptionValue:
  Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity)


eggNOGIndexTerm: COG2511
eggNOGDescriptionValue:
  Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The gatDE system is specific for glutamate and does not act on aspartate (By similarity)


eggNOGIndexTerm: COG2518
eggNOGDescriptionValue:
  Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity)


eggNOGIndexTerm: ENOG410Z0ND
eggNOGDescriptionValue:
  mediates the redistribution of the gamete fusogen HAP2 GCS1 to the cell surface after secretion upon sperm arrival


eggNOGIndexTerm: ENOG4110RUX
eggNOGDescriptionValue:
  Cardioactive peptide. Corazonin is probably involved in the physiological regulation of the heart beat (By similarity)


eggNOGIndexTerm: COG1080
eggNOGDescriptionValue:
  General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity)


eggNOGIndexTerm: ENOG410XXBZ
eggNOGDescriptionValue:
  Functions in complex with FlhD as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region


eggNOGIndexTerm: ENOG41119T3
eggNOGDescriptionValue:
  Required for translation of the mitochondrial OLI1 transcript encoding subunit 9 of mitochondrial ATP synthase (By similarity)


eggNOGIndexTerm: ENOG41119TI
eggNOGDescriptionValue:
  Required for cytoplasm to vacuole transport (Cvt) and autophagy as a part of the autophagy-specific vps34 PI3-kinase complex I. This complex is essential to recruit the atg8- phosphatidylinositol conjugate and the atg12-atg5 conjugate to the pre-autophagosomal structure. Atg14 mediates the specific binding of the vps34 PI3-kinase complex I to the preautophagosomal structure (PAS) (By similarity)


eggNOGIndexTerm: ENOG410Y2CQ
eggNOGDescriptionValue:
  Plays a role in cell wall integrity. Affects the cell wall polymer composition in the growing region of the cell (By similarity)


eggNOGIndexTerm: ENOG410Z3VJ
eggNOGDescriptionValue:
  Cell signaling peptide that may regulate plant stress, growth, and development. Mediates a rapid alkalinization of extracellular space by mediating a transient increase in the cytoplasmic Ca(2 ) concentration leading to a calcium-dependent signaling events through a cell surface receptor and a concomitant activation of some intracellular mitogen-activated protein kinases (By similarity)


eggNOGIndexTerm: ENOG41116U0
eggNOGDescriptionValue:
  Component of the biogenesis of lysosome-related organelles complex-1 (BLOC-1), a complex involved in endosomal cargo sorting (By similarity)


eggNOGIndexTerm: ENOG410Y5AT
eggNOGDescriptionValue:
  CONTAINS InterPro DOMAIN s Butirosin biosynthesis, BtrG-like (InterPro IPR013024), AIG2-like (InterPro IPR009288)


eggNOGIndexTerm: ENOG4111KYS
eggNOGDescriptionValue:
  Catalyzes the dephosphorylation of heptose(II) of the outer membrane lipopolysaccharide core (By similarity)


eggNOGIndexTerm: COG1159
eggNOGDescriptionValue:
  An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity)


eggNOGIndexTerm: COG1158
eggNOGDescriptionValue:
  Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity)


eggNOGIndexTerm: COG1155
eggNOGDescriptionValue:
  Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit (By similarity)


eggNOGIndexTerm: COG0162
eggNOGDescriptionValue:
  Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity)


eggNOGIndexTerm: COG0168
eggNOGDescriptionValue:
  Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity)


eggNOGIndexTerm: ENOG410ZXR3
eggNOGDescriptionValue:
  Component of the RIX1 complex required for processing of ITS2 sequences from 35S pre-rRNA (By similarity)


eggNOGIndexTerm: ENOG4112033
eggNOGDescriptionValue:
  Cytochrome c oxidase subunit which plays a role in assembly of respiratory supercomplexes (By similarity)


eggNOGIndexTerm: ENOG410ZM47
eggNOGDescriptionValue:
  Involved in nucleolar integrity and required for processing of the pre-rRNA for the 60S ribosome subunit


eggNOGIndexTerm: COG4973
eggNOGDescriptionValue:
  Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)


eggNOGIndexTerm: COG1634
eggNOGDescriptionValue:
  Catalyzes the transfer of pyrophosphate from ATP to 6- hydroxymethyl-7,8-dihydropterin (6-HMD), leading to 6- hydroxymethyl-7,8-dihydropterin diphosphate (6-HMDP) (By similarity)


eggNOGIndexTerm: COG1635
eggNOGDescriptionValue:
  Involved in biosynthesis of the thiamine precursor thiazole. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylic acid (ADT), an adenylated thiazole intermediate. The reaction includes an iron-dependent sulfide transfer from a conserved cysteine residue of the protein to a thiazole intermediate. The enzyme can only undergo a single turnover, which suggests it is a suicide enzyme. May have additional roles in adaptation to various stress conditions and in DNA damage tolerance (By similarity)


eggNOGIndexTerm: ENOG4110MY7
eggNOGDescriptionValue:
  Specifically required in males for proper segregation of autosomal bivalents at meiosis I. Expression is required in the male germ line prior to spermatocyte stage S4. May have a role as a bridging molecule maintaining adhesion to hold autosome bivalents together via heterochromatic connections (By similarity)


eggNOGIndexTerm: COG0020
eggNOGDescriptionValue:
  Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity)


eggNOGIndexTerm: ENOG410Z8I5
eggNOGDescriptionValue:
  Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity)


eggNOGIndexTerm: ENOG4111CH3
eggNOGDescriptionValue:
  DNA binding double-stranded telomeric DNA binding protein homodimerization single-stranded telomeric DNA binding transcription factor


eggNOGIndexTerm: ENOG410XWFQ
eggNOGDescriptionValue:
  Required for entry into the host cell through presentation or delivery of SipC at the host cell plasma membrane. Along with SipC, is necessary for the transfer of other effector proteins into the host cell. Induces macrophage apoptosis either by binding and activating the proapoptotic enzyme caspase-1 (caspase-1 dependent), resulting in the release of interleukin-1 beta active form, or by disrupting mitochondria and inducing autophagy (caspase-1 independent). The former is dependent of its membrane-fusion activity. The SipBC complex, in association with its chaperone SicA, is regulated by binding of InvE


eggNOGIndexTerm: ENOG4111HU8
eggNOGDescriptionValue:
  Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues


eggNOGIndexTerm: ENOG4110FDC
eggNOGDescriptionValue:
  PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity)


eggNOGIndexTerm: ENOG410XZN5
eggNOGDescriptionValue:
  Drosulfakinin-0 (DSK 0) plays diverse biological roles including regulating gut muscle contraction in adults but not in larvae


eggNOGIndexTerm: ENOG4110888
eggNOGDescriptionValue:
  1,4)-beta-D-glucans synthesis in grasses and cereals (Poaceae). The mixed-linked glucans (which are not present in walls of dicotyledons or most other monocotyledonous plants) are particularly important constituents of the walls of the starchy endosperm and aleurone cells of cereal grains such as oats, wheat, rice and barley. They can account for up to 70 by weight of the wall (By similarity)


eggNOGIndexTerm: COG0329
eggNOGDescriptionValue:
  Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity)


eggNOGIndexTerm: COG0324
eggNOGDescriptionValue:
  Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity)


eggNOGIndexTerm: COG0323
eggNOGDescriptionValue:
  This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity)


eggNOGIndexTerm: COG0322
eggNOGDescriptionValue:
  The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity)


eggNOGIndexTerm: COG0321
eggNOGDescriptionValue:
  Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity)


eggNOGIndexTerm: COG0320
eggNOGDescriptionValue:
  Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity)


eggNOGIndexTerm: COG0096
eggNOGDescriptionValue:
  One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity)


eggNOGIndexTerm: COG0541
eggNOGDescriptionValue:
  Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY


eggNOGIndexTerm: COG0544
eggNOGDescriptionValue:
  Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation


eggNOGIndexTerm: ENOG4112BIH
eggNOGDescriptionValue:
  E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Regulates centrosomal microtubule nucleation. Required for normal cell cycle progression from G2 to mitosis. Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle. Involved in transcriptional regulation of P21 in response to DNA damage. Required for FANCD2 targeting to sites of DNA damage. May function as a transcriptional regulator. Inhibits lipid synthesis by binding to inactive phosphorylated ACACA and preventing its dephosphorylation. Contributes to homologous recombination repair (HRR) via its direct interaction with PALB2, fine-tunes recombinational repair partly through its modulatory role in the PALB2-dependent loading of BRCA2-RAD51 repair machinery at DNA breaks. Component of the BRCA1-RBBP8 complex which regulates CHEK1 activation and controls cell cycle G2 M checkpoints on DNA damage via BRCA1-mediated ubiquitination of RBBP8


eggNOGIndexTerm: ENOG410YEZU
eggNOGDescriptionValue:
  May cause loosening and extension of plant cell walls by disrupting non-covalent bonding between cellulose microfibrils and matrix glucans. No enzymatic activity has been found


eggNOGIndexTerm: COG4869
eggNOGDescriptionValue:
  Involved in 1,2-propanediol (1,2-PD) degradation by catalyzing the conversion of propanoyl-CoA to propanoyl-phosphate (By similarity)


eggNOGIndexTerm: COG0763
eggNOGDescriptionValue:
  Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity)


eggNOGIndexTerm: ENOG410XPFM
eggNOGDescriptionValue:
  Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules. It also functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. Sec-13 is required for efficient mRNA export from the nucleus to the cytoplasm and for correct nuclear pore biogenesis and distribution (By similarity)


eggNOGIndexTerm: COG1478
eggNOGDescriptionValue:
  Catalyzes the GTP-dependent successive addition of two or more gamma-linked L-glutamates to the L-lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5-deazariboflavin (F420-0) to form coenzyme F420-0-glutamyl-glutamate (F420-2) or polyglutamated F420 derivatives (By similarity)


eggNOGIndexTerm: COG0266
eggNOGDescriptionValue:
  Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity)


eggNOGIndexTerm: COG0264
eggNOGDescriptionValue:
  Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity)


eggNOGIndexTerm: COG0263
eggNOGDescriptionValue:
  Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity)


eggNOGIndexTerm: COG0260
eggNOGDescriptionValue:
  Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity)


eggNOGIndexTerm: ENOG410Y6XC
eggNOGDescriptionValue:
  Involved in cell fusion during mating by stabilizing the plasma membrane fusion event (By similarity)


eggNOGIndexTerm: COG0448
eggNOGDescriptionValue:
  Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity)


eggNOGIndexTerm: COG0449
eggNOGDescriptionValue:
  Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity)


eggNOGIndexTerm: COG0442
eggNOGDescriptionValue:
  Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity)


eggNOGIndexTerm: COG0445
eggNOGDescriptionValue:
  NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity)


eggNOGIndexTerm: COG4776
eggNOGDescriptionValue:
  Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction (By similarity)


eggNOGIndexTerm: ENOG4111DWJ
eggNOGDescriptionValue:
  Component of the BUR kinase complex involved in transcription regulation. This complex phosphorylates the UBC2 RAD6 ubiquitin-conjugating enzyme (E2), leading to monoubiquitination of histone H2B and the silencing of telomeric- associated genes. Also required for histone H3 methylation. Necessary for the recovery from pheromone-induced growth arrest in the cell cycle G1 phase. The kinase activity of the complex requires the presence of BUR2. Overexpression of BUR2 interferes with mitotic chromosome segregation (By similarity)


eggNOGIndexTerm: COG3363
eggNOGDescriptionValue:
  Catalyzes the cyclization of 5-formylamidoimidazole-4- carboxamide ribonucleotide to IMP (By similarity)


eggNOGIndexTerm: ENOG410Y3W5
eggNOGDescriptionValue:
  Functions as a sorting receptor in the Golgi compartment required for the intracellular sorting and delivery of soluble vacuolar proteins, like carboxypeptidase Y (CPY) and proteinase A. Executes multiple rounds of sorting by cycling between the late Golgi and a prevacuolar endosome-like compartment


eggNOGIndexTerm: ENOG4110JYG
eggNOGDescriptionValue:
  Required for male development. In XO (male) animals, fem-3 directs male differentiation in all tissues. In XX (hermaphrodite animals), it specifies the first 80 or so germ cells to be sperm. Negatively regulates male development when bound to tra-2


eggNOGIndexTerm: COG1986
eggNOGDescriptionValue:
  Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions


eggNOGIndexTerm: COG1989
eggNOGDescriptionValue:
  Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue (By similarity)


eggNOGIndexTerm: ENOG4111JQM
eggNOGDescriptionValue:
  Plays a key role in early steps of protein N-linked glycosylation by being required for the conversion of polyprenol into dolichol. Dolichols are required for the synthesis of dolichol-linked monosaccharides and the oligosaccharide precursor used for N-glycosylation. Acts as a polyprenol reductase that promotes the reduction of the alpha-isoprene unit of polyprenols into dolichols in a NADP-dependent mechanism


eggNOGIndexTerm: COG1117
eggNOGDescriptionValue:
  Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity)


eggNOGIndexTerm: COG1110
eggNOGDescriptionValue:
  Modifies the topological state of DNA by introducing positive supercoils in an ATP-dependent process. It cleaves transiently a single DNA strand and remains covalently bound to the 5' DNA end through a tyrosine residue. May be involved in rewinding the DNA strands in the regions of the chromosome that have opened up to allow transcription or replication (By similarity)


eggNOGIndexTerm: ENOG410YF51
eggNOGDescriptionValue:
  Contributes to the efficiency of the cell division process by stabilizing the polymeric form of the cell division protein FtsZ. Acts by promoting interactions between FtsZ protofilaments and suppressing the GTPase activity of FtsZ (By similarity)


eggNOGIndexTerm: ENOG410YJD5
eggNOGDescriptionValue:
  Involved in the biosynthesis of the antibiotic, phenazine, a nitrogen-containing heterocyclic molecule having important roles in virulence, competition and biological control


eggNOGIndexTerm: ENOG4111P2W
eggNOGDescriptionValue:
  Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity)


eggNOGIndexTerm: COG2898
eggNOGDescriptionValue:
  Catalyzes the production of L-lysyl-tRNA(Lys)transfer and the transfer of a lysyl group from L-lysyl-tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), one of the components of the bacterial membrane with a positive net charge. LPG synthesis contributes to the resistance to cationic antimicrobial peptides (CAMPs) and likely protects M.tuberculosis against the CAMPs produced by competiting microorganisms (bacteriocins). In fact, the modification of anionic phosphatidylglycerol with positively charged L-lysine results in repulsion of the peptides


eggNOGIndexTerm: ENOG410YK7T
eggNOGDescriptionValue:
  Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in chloroplasts and mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho- Glu-tRNA(Gln) (By similarity)


eggNOGIndexTerm: ENOG4111RVN
eggNOGDescriptionValue:
  Required for homeostatic regulation of sleep under normal conditions and after sleep deprivation. Important regulator of the Sh K( ) channel, acting as a signaling molecule that connects sleep drive to lowered membrane excitability, possibly by enhancing K( ) channel activity and thus reducing neuronal excitability


eggNOGIndexTerm: ENOG4111V4B
eggNOGDescriptionValue:
  Antitoxin component of a toxin-antitoxin (TA) module. Labile antitoxin that counteracts the effect of the CbtA (YeeV) toxin. It does not bind to the cognate toxin but instead binds to MreB and FtsZ (the toxin targets), enhancing their polymerization by forming higher-order bundles


eggNOGIndexTerm: ENOG4111TZ1
eggNOGDescriptionValue:
  Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane


eggNOGIndexTerm: ENOG411215X
eggNOGDescriptionValue:
  Cell surface-associated protein implicated in virulence by promoting bacterial attachment to both alpha- and beta-chains of human fibrinogen and inducing the formation of bacterial clumps


eggNOGIndexTerm: COG1676
eggNOGDescriptionValue:
  sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. Recognizes a pseudosymmetric substrate in which 2 bulged loops of 3 bases are separated by a stem of 4 bp (By similarity)


eggNOGIndexTerm: COG1675
eggNOGDescriptionValue:
  Transcription factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Facilitates transcription initiation by enhancing TATA-box recognition by TATA-box-binding protein (Tbp), and transcription factor B (Tfb) and RNA polymerase recruitment. Not absolutely required for transcription in vitro, but particularly important in cases where Tbp or Tfb function is not optimal. It dynamically alters the nucleic acid-binding properties of RNA polymerases by stabilizing the initiation complex and destabilizing elongation complexes. Seems to translocate with the RNA polymerase following initiation and acts by binding to the non template strand of the transcription bubble in elongation complexes


eggNOGIndexTerm: COG0065
eggNOGDescriptionValue:
  Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity)


eggNOGIndexTerm: COG0060
eggNOGDescriptionValue:
  amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity)


eggNOGIndexTerm: COG0061
eggNOGDescriptionValue:
  Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity)


eggNOGIndexTerm: ENOG41129BS
eggNOGDescriptionValue:
  Transfers 2'-(5-triphosphoribosyl)-3'-dephosphocoenzyme- A to the apo- acyl-carrier-protein of the malonate decarboxylase to yield holo- acyl-carrier-protein (By similarity)


eggNOGIndexTerm: ENOG4111386
eggNOGDescriptionValue:
  Primary component of whey, it binds retinol and is probably involved in the transport of that molecule


eggNOGIndexTerm: COG3724
eggNOGDescriptionValue:
  Catalyzes the hydrolysis of N(2)-succinylarginine into N(2)-succinylornithine, ammonia and CO(2) (By similarity)


eggNOGIndexTerm: ENOG41117E3
eggNOGDescriptionValue:
  Component of the spliceosome and rRNA processing machinery. In association with the spliceosomal U4 U6.U5 tri-snRNP particle, required for splicing of pre-mRNA (By similarity)


eggNOGIndexTerm: ENOG411169T
eggNOGDescriptionValue:
  Required for respiratory activity and maintenance and expression of the mitochondrial genome (By similarity)


eggNOGIndexTerm: ENOG411169G
eggNOGDescriptionValue:
  Plays a role in starvation-induced autophagy. Involved in mitophagy. Functions with ATG17 and ATG29 at the preautophagosomal structure (PAS) in order to form normal autophagosomes under starvation conditions. May be involved in microtubule function, such as chromosome segregation and karyogamy


eggNOGIndexTerm: ENOG4111697
eggNOGDescriptionValue:
  Transcriptional activator which promotes cell cycle recovery, after pheromone induced G1 arrest. May also be involved in stress-resistance (By similarity)


eggNOGIndexTerm: COG1712
eggNOGDescriptionValue:
  Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate (By similarity)


eggNOGIndexTerm: COG0509
eggNOGDescriptionValue:
  The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity)


eggNOGIndexTerm: COG0504
eggNOGDescriptionValue:
  Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity)


eggNOGIndexTerm: COG0503
eggNOGDescriptionValue:
  Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity)


eggNOGIndexTerm: ENOG41101EP
eggNOGDescriptionValue:
  Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)


eggNOGIndexTerm: COG1436
eggNOGDescriptionValue:
  Subunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells (By similarity)


eggNOGIndexTerm: COG0407
eggNOGDescriptionValue:
  Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity)


eggNOGIndexTerm: COG0408
eggNOGDescriptionValue:
  Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity)


eggNOGIndexTerm: COG1352
eggNOGDescriptionValue:
  catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity)


eggNOGIndexTerm: ENOG41115QC
eggNOGDescriptionValue:
  CONTAINS InterPro DOMAIN s Heat shock protein Hsp20 (InterPro IPR002068), HSP20-like chaperone (InterPro IPR008978)


eggNOGIndexTerm: ENOG41125KS
eggNOGDescriptionValue:
  Inhibits RpoS proteolysis by regulating RssB activity, thereby increasing the stability of the sigma stress factor RpoS during magnesium starvation (By similarity)


eggNOGIndexTerm: ENOG410ZX75
eggNOGDescriptionValue:
  Involved in the initiation of assembly of the COPII coat required for the formation of transport vesicles from the endoplasmic reticulum (ER) and the selection of cargo molecules. Also involved in autophagy


eggNOGIndexTerm: COG1518
eggNOGDescriptionValue:
  CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. May be involved in the integration of spacer DNA into the CRISPR cassette (By similarity)


eggNOGIndexTerm: COG1156
eggNOGDescriptionValue:
  Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit (By similarity)


eggNOGIndexTerm: COG1154
eggNOGDescriptionValue:
  Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity)


eggNOGIndexTerm: COG4138
eggNOGDescriptionValue:
  Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system (By similarity)


eggNOGIndexTerm: COG4139
eggNOGDescriptionValue:
  Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Involved in the translocation of the substrate across the membrane (By similarity)


eggNOGIndexTerm: COG4133
eggNOGDescriptionValue:
  once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system (By similarity)


eggNOGIndexTerm: ENOG410XRUJ
eggNOGDescriptionValue:
  Component of the ERMES MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis and may function in phospholipid exchange. MDM12 is required for the interaction of the ER-resident membrane protein MMM1 and the outer mitochondrial membrane-resident beta-barrel protein MDM10. The MDM12-MMM1 subcomplex functions in the major beta-barrel assembly pathway that is responsible for biogenesis of all mitochondrial outer membrane beta-barrel proteins, and acts in a late step after the SAM complex. The MDM10-MDM12-MMM1 subcomplex further acts in the TOM40-specific pathway after the action of the MDM12-MMM1 complex. Essential for establishing and maintaining the structure of mitochondria and maintenance of mtDNA nucleoids (By similarity)


eggNOGIndexTerm: COG0706
eggNOGDescriptionValue:
  Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins


eggNOGIndexTerm: ENOG4111QBB
eggNOGDescriptionValue:
  Involved in DNA replication, genome stability, and the control of cell cycle, probably through its association to replication origins to facilitate the ubiquitination of another origin-binding protein


eggNOGIndexTerm: ENOG410YAX4
eggNOGDescriptionValue:
  Toxic component of a toxin-antitoxin (TA) module. A stable (half-life 27.6 minutes) endoribonuclease that in the absence of cognate antitoxin RnlB causes generalized RNA degradation. Degrades late enterobacteria phage T4 mRNAs, protecting the host against T4 reproduction. Activity is inhibited by cognate antitoxin RnlB and by enterobacteria phage T4 protein Dmd. Targets cyaA mRNA


eggNOGIndexTerm: ENOG410ZYTP
eggNOGDescriptionValue:
  Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity)


eggNOGIndexTerm: ENOG410Y920
eggNOGDescriptionValue:
  Involved in light-induced Na( )-dependent proton extrusion. Also seems to be involved in CO(2) transport (By similarity)


eggNOGIndexTerm: ENOG4110672
eggNOGDescriptionValue:
  Plays role in broad-spectrum disease resistance. Probably has no oxalate oxidase activity even if the active site is conserved


eggNOGIndexTerm: ENOG410Y0DB
eggNOGDescriptionValue:
  Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein (By similarity)


eggNOGIndexTerm: COG3622
eggNOGDescriptionValue:
  Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity)


eggNOGIndexTerm: ENOG41119T9
eggNOGDescriptionValue:
  Component of the spindle pole body (SPB) required for insertion of the nascent SPB into the nuclear envelope and for the proper execution of spindle pole body (SPB) duplication. Connects the central plaque of the SPB with the half-bridge. Required for proper localization of CDC5 at the SPB and for proper M-phase progression (By similarity)


eggNOGIndexTerm: COG3633
eggNOGDescriptionValue:
  Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system) (By similarity)


eggNOGIndexTerm: ENOG41119TJ
eggNOGDescriptionValue:
  Component of the COP9 signalosome (CSN) complex that acts as an regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunit of SCF-type E3 ubiquitin-protein ligase complexes The CSN complex is involved in the regulation of the mating pheromone response


eggNOGIndexTerm: ENOG410YG07
eggNOGDescriptionValue:
  Rod-core linker protein required for attachment of phycocyanin to allophycocyanin in cores of phycobilisomes (By similarity)


eggNOGIndexTerm: ENOG411280E
eggNOGDescriptionValue:
  Involved in proper assembly of pre-ribosomal particles during the biogenesis of the 60S ribosomal subunit. Accompanies the pre-60S particles to the cytoplasm (By similarity)


eggNOGIndexTerm: COG4582
eggNOGDescriptionValue:
  Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity (By similarity)


eggNOGIndexTerm: ENOG4111Z9U
eggNOGDescriptionValue:
  Catalyzes the acylation of glycosyl-4,4'- diaponeurosporenoate, i.e. the esterification of glucose at the C6'' position with the carboxyl group of the C(15) fatty acid 12- methyltetradecanoic acid, to yield staphyloxanthin. This is the last step in the biosynthesis of this orange pigment, present in most staphylococci strains (By similarity)


eggNOGIndexTerm: ENOG410YYKB
eggNOGDescriptionValue:
  Functions as extracellular chaperone that prevents aggregation of nonnative proteins. Prevents stress-induced aggregation of blood plasma proteins. Inhibits formation of amyloid fibrils by APP, APOC2, B2M, CALCA, CSN3, SNCA and aggregation-prone LYZ variants (in vitro). Does not require ATP. Maintains partially unfolded proteins in a state appropriate for subsequent refolding by other chaperones, such as HSPA8 HSC70. Does not refold proteins by itself. Binding to cell surface receptors triggers internalization of the chaperone-client complex and subsequent lysosomal or proteasomal degradation. When secreted, protects cells against apoptosis and against cytolysis by complement. Intracellular forms interact with ubiquitin and SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes and promote the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes proteasomal degradation of COMMD1 and IKBKB. Modulates NF-kappa-B transcriptional activity. Promotes apoptosis when in the nucleus. Inhibits apoptosis when associated with the mitochondrial membrane by interference with BAX-dependent release of cytochrome c into the cytoplasm. Plays a role in the regulation of cell proliferation (By similarity)


eggNOGIndexTerm: ENOG410YYKM
eggNOGDescriptionValue:
  Component of the biogenesis of lysosome-related organelles complex-1 (BLOC-1), a complex that is involved in endosomal cargo sorting (By similarity)


eggNOGIndexTerm: COG1420
eggNOGDescriptionValue:
  Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity)


eggNOGIndexTerm: ENOG410Y4ID
eggNOGDescriptionValue:
  Part of the elfADCG-ycbUVF fimbrial operon, which promotes adhesion of bacteria to different abiotic surfaces. ElfA is the major fimbrial subunit produced by this operon


eggNOGIndexTerm: ENOG411169Y
eggNOGDescriptionValue:
  Relaxin is an ovarian hormone that acts with estrogen to produce dilatation of the birth canal in many mammals


eggNOGIndexTerm: COG5271
eggNOGDescriptionValue:
  Nuclear chaperone required for maturation and nuclear export of pre-60S ribosome subunits (By similarity)


eggNOGIndexTerm: ENOG410ZBUB
eggNOGDescriptionValue:
  Probably a connector protein for RcsB C regulation of biofilm formation, providing additional signal input into the two- component signaling pathway. May serve to stimulate biofilm maturation, probably via the Rcs phosphorelay. Mild overexpression at 16 degrees Celsius increases the production of colanic acid, an exopolysaccharide and matrix component, and reduces adhesive curli fimbriae expression. Both of these effects require RcsB


eggNOGIndexTerm: COG0484
eggNOGDescriptionValue:
  ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)


eggNOGIndexTerm: COG0481
eggNOGDescriptionValue:
  Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity)


eggNOGIndexTerm: ENOG4111IQF
eggNOGDescriptionValue:
  Binds to the sigma-S subunit of RNA polymerase, activating expression of sigma-S-regulated genes. Stimulates RNA polymerase holoenzyme formation and may bind to several other sigma factors, such as sigma-70 and sigma-32 (By similarity)


eggNOGIndexTerm: COG1756
eggNOGDescriptionValue:
  Methyltransferase involved in ribosomal biogenesis. Specifically catalyzes the N1-methylation of the pseudouridine corresponding to position 914 in M.jannaschii 16S rRNA (By similarity)


eggNOGIndexTerm: COG1759
eggNOGDescriptionValue:
  Catalyzes the ATP- and formate-dependent formylation of 5-aminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'- monophosphate (AICAR) to 5-formaminoimidazole-4-carboxamide-1- beta-d-ribofuranosyl 5'-monophosphate (FAICAR) in the absence of folates (By similarity)


eggNOGIndexTerm: ENOG4111YS8
eggNOGDescriptionValue:
  Involved in the control of energetic metabolism and significantly contribute to cell fitness, especially under respiratory growth conditions (By similarity)


eggNOGIndexTerm: ENOG411185H
eggNOGDescriptionValue:
  maternally provided protein is sufficient until mitosis 14 then zygotic protein is required. Involved in formation and or maintenance of epithelial structures bud extension during Malpighian tubule development, and foregut and hindgut morphogenesis


eggNOGIndexTerm: COG4257
eggNOGDescriptionValue:
  Inactivates the type B streptogramin antibiotics by linearizing the lactone ring at the ester linkage, generating a free phenylglycine carboxylate and converting the threonyl moiety into 2-amino-butenoic acid


eggNOGIndexTerm: ENOG410XSWR
eggNOGDescriptionValue:
  Trans-acting protein required for termination of DNA replication. Binds to DNA replication terminator sequences (terA to terF) to prevent the passage of replication forks. The termination efficiency will be affected by the affinity of this protein for the terminator sequence (By similarity)


eggNOGIndexTerm: COG3060
eggNOGDescriptionValue:
  This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis (By similarity)


eggNOGIndexTerm: COG3066
eggNOGDescriptionValue:
  Sequence-specific endonuclease that cleaves unmethylated GATC sequences. It is involved in DNA mismatch repair (By similarity)


eggNOGIndexTerm: ENOG410XQ42
eggNOGDescriptionValue:
  Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex involved in cytoplasmic mRNA turnover. PAN specifically shortens poly(A) tails of RNA when the poly(A) stretch is bound by polyadenylate-binding protein pab1. Deadenylation of the 3'-tail to a length that is too short to bind pab1 induces mRNA decay. May also be involved in post- transcriptional maturation of mRNA poly(A) tails. pan3 acts as a positive regulator for PAN activity, recruiting pan2 to mRNA via its interaction with pab1 (By similarity)


eggNOGIndexTerm: ENOG410YIRA
eggNOGDescriptionValue:
  Aux IAA proteins are short-lived transcriptional factors that function as repressors of early auxin response genes at low auxin concentrations


eggNOGIndexTerm: ENOG410YCD0
eggNOGDescriptionValue:
  Involved in the processing or stability of mitochondrial mRNAs. Required for meiotic nuclear division


eggNOGIndexTerm: COG1452
eggNOGDescriptionValue:
  involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity)


eggNOGIndexTerm: ENOG410XPNS
eggNOGDescriptionValue:
  Converts stearoyl-ACP to oleoyl-ACP by introduction of a cis double bond between carbons Delta(9) and Delta(10) of the acyl chain


eggNOGIndexTerm: COG1536
eggNOGDescriptionValue:
  FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity)


eggNOGIndexTerm: COG1219
eggNOGDescriptionValue:
  ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity)


eggNOGIndexTerm: COG1211
eggNOGDescriptionValue:
  Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity)


eggNOGIndexTerm: ENOG410YTDG
eggNOGDescriptionValue:
  Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity)


eggNOGIndexTerm: ENOG410ZJDG
eggNOGDescriptionValue:
  Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events


eggNOGIndexTerm: COG3120
eggNOGDescriptionValue:
  Required for spatial organization of the terminus region of the chromosome (Ter macrodomain) during the cell cycle. Prevents early segregation of duplicated Ter macrodomains during cell division. Binds specifically to matS, which is a 13 bp signature motif repeated within the Ter macrodomain (By similarity)


eggNOGIndexTerm: ENOG410XS44
eggNOGDescriptionValue:
  extension of a leading process involved in cell motility in cerebral cortex radial glia guided migration


eggNOGIndexTerm: ENOG410Z6DR
eggNOGDescriptionValue:
  Transposase of ISThsp10, IS21 family, C terminal part. There is a STOP codon in phase at position 341 of the transposase. Complete transposase coordinates complement (1298282-1299808)


eggNOGIndexTerm: ENOG4111VMB
eggNOGDescriptionValue:
  Plays a role in the extracellular assembly of CsgA into thin aggregative fimbriae (Tafi) fibers. Assembly may also require CsgE. Tafi are thought to be assembled via an extracellular nucleation-precipitation (ENP) pathway, and possibly also via an intracellular non-CsgC-dependent pathway (By similarity)


eggNOGIndexTerm: COG5031
eggNOGDescriptionValue:
  Component of the coenzyme Q biosynthetic pathway. May play a role in organizing a multi-subunit COQ enzyme complex required for coenzyme Q biosynthesis. Required for steady-state levels of other COQ polypeptides (By similarity)


eggNOGIndexTerm: ENOG4111C1J
eggNOGDescriptionValue:
  these ligands are up-regulated by stress conditions and pathological state such as viral infection and tumor transformation. Functions as docking site for PI3-kinase PIK3R1 and GRB2. Interaction of ULBPs with NKG2D-DAP10 triggers calcium mobilization and activation of the PIK3R1, MAP2K ERK, and JAK2 STAT5 signaling pathways. Both PIK3R1 and GRB2 are required for full NKG2D-HCST-mediated activation and ultimate killing of target cells. In NK cells, NKG2D-HCST signaling directly induces cytotoxicity and enhances cytokine production initiated via DAP12 TYROBP-associated receptors. In T-cells, it provides primarily costimulation for TCR-induced signals. NKG2D-HCST receptor plays a role in immune surveillance against tumors and is required for cytolysis of tumors cells


eggNOGIndexTerm: COG2908
eggNOGDescriptionValue:
  Catalyzes the hydrolysis of the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1- phosphate (lipid X) and UMP (By similarity)


eggNOGIndexTerm: COG2904
eggNOGDescriptionValue:
  Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity)


eggNOGIndexTerm: COG1553
eggNOGDescriptionValue:
  Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE (By similarity)


eggNOGIndexTerm: COG0825
eggNOGDescriptionValue:
  Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity)


eggNOGIndexTerm: ENOG410YYAE
eggNOGDescriptionValue:
  transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity)


eggNOGIndexTerm: COG1370
eggNOGDescriptionValue:
  Exchanges the guanine residue with 7-cyano-7- deazaguanine (preQ0) at position 15 in the dihydrouridine loop (D- loop) of archaeal tRNAs (By similarity)


eggNOGIndexTerm: COG0743
eggNOGDescriptionValue:
  Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity)


eggNOGIndexTerm: ENOG4110JA7
eggNOGDescriptionValue:
  transcription factor) to enter the nucleus and promote female development. In XO animals it acts as a receptor for her-1 which prevents it from binding to FEM proteins thereby repressing the activity of tra-1. Negatively regulates male development when bound to fem-3 and is required together with tra-1 for promoting spermatogenesis


eggNOGIndexTerm: COG0063
eggNOGDescriptionValue:
  Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity)


eggNOGIndexTerm: COG4656
eggNOGDescriptionValue:
  Required for nitrogen fixation. May be part of a membrane complex functioning as an intermediate in the electron transport to nitrogenase (By similarity)


eggNOGIndexTerm: ENOG4111QFZ
eggNOGDescriptionValue:
  Curli are coiled surface structures that assemble preferentially at growth temperatures below 37 degrees Celsius. Curli can bind to fibronectin


eggNOGIndexTerm: ENOG411197B
eggNOGDescriptionValue:
  Plays an important role in the regulation of interdigestive gastrointestinal motility and indirectly causes rhythmic contraction of duodenal and colonic smooth muscle


eggNOGIndexTerm: COG0692
eggNOGDescriptionValue:
  Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity)


eggNOGIndexTerm: COG0691
eggNOGDescriptionValue:
  Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity)


eggNOGIndexTerm: ENOG410YT5M
eggNOGDescriptionValue:
  Component of the U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region (By similarity)


eggNOGIndexTerm: COG0161
eggNOGDescriptionValue:
  Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity)


eggNOGIndexTerm: ENOG410Y557
eggNOGDescriptionValue:
  Chaperone required for the export of the chitin synthase chs3 from the endoplasmic reticulum (By similarity)


eggNOGIndexTerm: ENOG41106VT
eggNOGDescriptionValue:
  Pectinolytic enzymes consist of four classes of enzymes pectin lyase, polygalacturonase, pectin methylesterase and rhamnogalacturonase. Among pectinolytic enzymes, pectin lyase is the most important in depolymerization of pectin, since it cleaves internal glycosidic bonds of highly methylated pectins (By similarity)


eggNOGIndexTerm: ENOG4111ECS
eggNOGDescriptionValue:
  to encode a PR (pathogenesis-related) protein. Belongs to the plant thionin (PR-13) family with the following members At1g66100, At5g36910, At1g72260, At2g15010, At1g12663, At1g12660


eggNOGIndexTerm: COG1974
eggNOGDescriptionValue:
  Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity)


eggNOGIndexTerm: COG1976
eggNOGDescriptionValue:
  Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm


eggNOGIndexTerm: COG1970
eggNOGDescriptionValue:
  Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity)


eggNOGIndexTerm: ENOG4111D7W
eggNOGDescriptionValue:
  RNA-binding protein involved in deadenylation-dependent decapping of mRNAs, leading to the degradation of mRNAs. Acts as a scaffold protein that connects deadenylation and decapping machinery (By similarity)


eggNOGIndexTerm: COG0805
eggNOGDescriptionValue:
  Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity)


eggNOGIndexTerm: ENOG410Y1SD
eggNOGDescriptionValue:
  to Bacteriophage D3 Orf25 SWALL Q9MC96 (EMBL AF165214) (135 aa) fasta scores E() 0.00047, 30.46 id in 128 aa


eggNOGIndexTerm: ENOG410XP00
eggNOGDescriptionValue:
  DEAD-box RNA helicase-like protein required for pre-18S rRNA processing, specifically at sites A0, A1, and A2 (By similarity)


eggNOGIndexTerm: ENOG410YWKB
eggNOGDescriptionValue:
  Involved in ribosome biogenesis. Required for normal pre-rRNA processing in internal transcribed spacer 1 (ITS1). May be involved in the movements of the replication forks (By similarity)


eggNOGIndexTerm: COG0099
eggNOGDescriptionValue:
  Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits


eggNOGIndexTerm: COG0098
eggNOGDescriptionValue:
  Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity)


eggNOGIndexTerm: COG0094
eggNOGDescriptionValue:
  This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits


eggNOGIndexTerm: COG0097
eggNOGDescriptionValue:
  This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity)


eggNOGIndexTerm: COG0091
eggNOGDescriptionValue:
  The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity)


eggNOGIndexTerm: COG0090
eggNOGDescriptionValue:
  One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity


eggNOGIndexTerm: COG0092
eggNOGDescriptionValue:
  Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity)


eggNOGIndexTerm: ENOG411196W
eggNOGDescriptionValue:
  Also required for ubiquitination of histone H2B to form H2BK123ub1. H2BK123ub1 gives a specific tag for epigenetic transcriptional activation, telomeric silencing, and is also a prerequisite for H3K4me and H3K79me formation. Its precise role in H2BK123ub1 formation however is unclear


eggNOGIndexTerm: ENOG411196P
eggNOGDescriptionValue:
  In the elongating spermatids of mammals, the conversion of nucleosomal chromatin to the compact, non-nucleosomal form found in the sperm nucleus is associated with the appearance of a small set of basic chromosomal transition proteins (By similarity)


eggNOGIndexTerm: ENOG4111IUP
eggNOGDescriptionValue:
  May be a transcriptional activator of genes involved in the multiple antibiotic resistance (Mar) phenotype. It can also activate genes such as sodA, zwf and micF


eggNOGIndexTerm: ENOG410XUVY
eggNOGDescriptionValue:
  Cross-linked envelope protein of keratinocytes. It is a keratinocyte protein that first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase. All that results in the formation of an insoluble envelope beneath the plasma membrane


eggNOGIndexTerm: COG2168
eggNOGDescriptionValue:
  Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions (By similarity)


eggNOGIndexTerm: COG0580
eggNOGDescriptionValue:
  Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity)


eggNOGIndexTerm: ENOG410XQ0K
eggNOGDescriptionValue:
  Transmembrane component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Required for ciliogenesis and sonic hedgehog SHH signaling


eggNOGIndexTerm: ENOG4110ING
eggNOGDescriptionValue:
  Proposed to be part of the KMN network incorporating the MIS12 complex and NDC80 complex that is required for establishing the kinetochore-microtubule interface that aids in chromosome segregation during meiotic and mitotic cell division. Appears to function downstream of hcp-3 (CENP-A) and hcp-4 (CENP-C) in the kinetochore assembly hierarchy. Has a role in the correct localization of spdl-1 and the RZZ complex that is composed of rod-1, czw-1 and zwl-1


eggNOGIndexTerm: ENOG410XTS6
eggNOGDescriptionValue:
  Member of the ChAPs family of proteins (Chs5p-Arf1p-binding proteins Bch1p, Bch2p, Bud7p, Chs6p), that forms the exomer complex with Chs5p to mediate export of specific cargo proteins, including Chs3p, from the Golgi to the plasma membrane


eggNOGIndexTerm: COG0787
eggNOGDescriptionValue:
  Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity)


eggNOGIndexTerm: COG2022
eggNOGDescriptionValue:
  Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity)


eggNOGIndexTerm: COG0480
eggNOGDescriptionValue:
  Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity)


eggNOGIndexTerm: COG2262
eggNOGDescriptionValue:
  GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity)


eggNOGIndexTerm: COG4574
eggNOGDescriptionValue:
  General inhibitor of pancreatic serine proteases inhibits chymotrypsin, trypsin, elastases, factor X, kallikrein as well as a variety of other proteases (By similarity)


eggNOGIndexTerm: COG4573
eggNOGDescriptionValue:
  that is required for full activity and stability of the Y subunit. Could have a chaperone-like function for the proper and stable folding of


eggNOGIndexTerm: COG4570
eggNOGDescriptionValue:
  Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC (By similarity)


eggNOGIndexTerm: COG4579
eggNOGDescriptionValue:
  Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation (By similarity)


eggNOGIndexTerm: COG3161
eggNOGDescriptionValue:
  Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4- hydroxybenzoate (4HB) for the ubiquinone pathway (By similarity)


eggNOGIndexTerm: ENOG410XUDE
eggNOGDescriptionValue:
  Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner


eggNOGIndexTerm: ENOG41107A7
eggNOGDescriptionValue:
  Plant non-specific lipid-transfer proteins transfer phospholipids as well as galactolipids across membranes. May play a role in wax or cutin deposition in the cell walls of expanding epidermal cells and certain secretory tissues


eggNOGIndexTerm: ENOG41121A4
eggNOGDescriptionValue:
  Actin-binding protein that interferes with host cell actin cytoskeleton. Nucleates actin polymerization and condensates actin filaments into cables (bundling). SipA potenciates SipC activity and both are required for an efficient bacterial internalization by the host cell (By similarity)


eggNOGIndexTerm: ENOG4111AC1
eggNOGDescriptionValue:
  are negative regulators of the filamentation and pheromone induced mating program. DIG1 and DIG2 inhibit the transcriptional activity of STE12 by direct protein- protein interaction


eggNOGIndexTerm: ENOG4111ACE
eggNOGDescriptionValue:
  Involved in chromosome segregation during meiosis. Promotes efficient recombinational repair and functions in the protection of the genome from spontaneous and induced DNA damage like mutations and gross chromosomal rearrangements (GCRs)


eggNOGIndexTerm: ENOG4111ACU
eggNOGDescriptionValue:
  RNA-binding protein that binds specific mRNAs including the ASH1 mRNA, coding for a repressor of the HO endonuclease. Part of the mRNA localization machinery that restricts accumulation of certain proteins to the bud and in the daughter cell


eggNOGIndexTerm: COG1339
eggNOGDescriptionValue:
  Catalyzes the CTP-dependent phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN) (By similarity)


eggNOGIndexTerm: COG0100
eggNOGDescriptionValue:
  Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity)


