# go

id: GO:0043852
name: monomethylamine methyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: monomethylamine + a monomethylamine corrinoid protein = a methylated monomethylamine corrinoid protein + NH3." [IMG:01319, MetaCyc:RXN-8098]


id: GO:0043853
name: methanol-CoM methyltransferase complex
namespace: cellular_component
def:
  "A heterotrimeric protein complex composed of a methanol methyltransferase subunit, a corrinoid protein and a methanol-specific corrinoid:coenzyme M methyltransferase subunit. Catalyzes the transfer of a methyl group from methanol to coenzyme M as part of the pathway of methanogenesis from methanol." [IMG:01437, MetaCyc:CPLX-421, PMID:9363780]


id: GO:0043854
name: cyclic nucleotide-gated mechanosensitive ion channel activity
namespace: molecular_function
def:
  "Enables the transmembrane transfer of an ion by a channel that opens in response to a mechanical stress and when a cyclic nucleotide has been bound by the channel complex or one of its constituent parts." [GOC:jl, IMG:02416]


id: GO:0043855
name: cyclic nucleotide-gated ion channel activity
namespace: molecular_function
def:
  "Enables the transmembrane transfer of an ion by a channel that opens when a cyclic nucleotide has been bound by the channel complex or one of its constituent parts." [GOC:jl]


id: GO:0043856
name: anti-sigma factor antagonist activity
namespace: molecular_function
def:
  "The function of binding to an anti-sigma factor and stopping, preventing or reducing the rate of its activity." [GOC:jl, GOC:txnOH, PMID:15576799]


id: GO:0043857
name: N-acetylornithine carbamoyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: N(2)-acetyl-L-ornithine + carbamoyl phosphate = N(2)-acetyl-L-citrulline + H(+) + phosphate." [EC:2.1.3.9, RHEA:18612]


id: GO:0043858
name: arginine:ornithine antiporter activity
namespace: molecular_function
def:
  "Catalysis of the reaction: arginine(out) + ornithine(in) = arginine(in) + ornithine(out)." [GOC:jl, PMID:17110979]


id: GO:0043859
name: obsolete cyanophycinase activity
namespace: molecular_function
def:
  "OBSOLETE. Catalysis of the hydrolytic cleavage of multi-L-arginyl-poly-L-aspartic acid (cyanophycin; a water-insoluble reserve polymer) into aspartate-arginine dipeptides." [PMID:10429200]


id: GO:0043860
name: cyanophycin synthetase activity
namespace: molecular_function
def:
  "Catalysis of the ATP-dependent polymerization of arginine and aspartate to multi-L-arginyl-poly-L-aspartic acid (cyanophycin; a water-insoluble reserve polymer)." [EC:6.3.2.29, EC:6.3.2.30, GOC:jl]


id: GO:0043861
name: agmatine:putrescine antiporter activity
namespace: molecular_function
def:
  "Catalysis of the reaction: agmatine(out) + putrescine(in) = agmatine(in) + putrescine(out)." [GOC:jl, PMID:17028272]


id: GO:0043862
name: arginine:agmatine antiporter activity
namespace: molecular_function
def:
  "Catalysis of the reaction: arginine(out) + agmatine(in) = arginine(in) + agmatine(out)." [GOC:jl, PMID:17099215]


id: GO:0043863
name: 4-hydroxy-2-ketopimelate aldolase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 4-hydroxy-2-ketopimelate = succinate semialdehyde + pyruvate." [MetaCyc:4-HYDROXY-2-KETOPIMELATE-LYSIS-RXN]


id: GO:0043864
name: indoleacetamide hydrolase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: indole-3-acetamide + H2O = indole-3-acetate + NH3. Indole-3-acetamide is known as IAM and indole-3-acetate as IAA." [GOC:jl, MetaCyc:RXNN-404]


id: GO:0043866
name: adenylyl-sulfate reductase (thioredoxin) activity
namespace: molecular_function
def:
  "Catalysis of the reaction: AMP + sulfite + thioredoxin disulfide = 5'-adenylyl sulfate + thioredoxin." [EC:1.8.4.10]


id: GO:0043867
name: 7-cyano-7-deazaguanine tRNA-ribosyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: tRNA guanine + 7-cyano-7-deazaguanine = tRNA 7-cyano-7-deazaguanine + guanine." [PMID:16407303, PMID:7748953]


id: GO:0043869
name: alpha-aminoadipate acetyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: alpha-aminoadipate + acetyl-CoA = N2-acetyl-alpha-aminoadipate + coenzyme A." [MetaCyc:RXN-5181, PMID:10613839, PMID:12925802]


id: GO:0043870
name: N-acetyl-gamma-aminoadipyl-phosphate reductase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: N(2)-acetyl-L-aminoadipate-semialdehyde + NADP+ + phosphate = N(2)-acetyl-L-gamma-aminoadipyl phosphate + NADPH." [MetaCyc:RXN-5183]


id: GO:0043871
name: delta1-piperideine-6-carboxylate dehydrogenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: delta1-piperideine-6-carboxylate + NAD+ + 2 H2O = 2-aminoadipate + NADH + H+. Delta1-piperideine-6-carboxylate is also known as 2,3,4,5-tetrahydropyridine-2-carboxylate." [MetaCyc:RXN-8162, PMID:16237033]


id: GO:0043872
name: lysine:cadaverine antiporter activity
namespace: molecular_function
def:
  "Catalysis of the reaction: lysine(out) + cadaverine(in) = lysine(in) + cadaverine(out)." [GOC:jl, PMID:10986235, TC:2.A.3.2.2]


id: GO:0043873
name: pyruvate-flavodoxin oxidoreductase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: pyruvate + CoA + oxidized flavodoxin = acetyl-CoA + CO2 + reduced flavodoxin." [PMID:6352705]


id: GO:0043874
name: acireductone synthase activity
namespace: molecular_function
def:
  "Catalysis of the reactions: 5-(methylthio)-2,3-dioxopentyl phosphate + H2O = 1,2-dihydroxy-5-(methylthio)pent-1-en-3-one + phosphate; (1a) 5-(methylthio)-2,3-dioxopentyl phosphate = 2-hydroxy-5-(methylthio)-3-oxopent-1-enyl phosphate; (1b) 2-hydroxy-5-(methylthio)-3-oxopent-1-enyl phosphate + H2O = 1,2-dihydroxy-5-(methylthio)pent-1-en-3-one + phosphate." [EC:3.1.3.77]


id: GO:0043875
name: 2-ketobutyrate formate-lyase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 2-oxobutanoate + coenzyme A = propionyl-CoA + formate." [MetaCyc:KETOBUTFORMLY-RXN, PMID:9484901]


id: GO:0043876
name: D-threonine aldolase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: D-threonine (or D-allo-threonine) = glycine + acetaldehyde." [MetaCyc:4.1.2.42-RXN, PMID:9642221]


id: GO:0043877
name: galactosamine-6-phosphate isomerase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: D-galactosamine 6-phosphate + H2O = D-tagatose 6-phosphate + NH3." [PMID:10931310]


id: GO:0043878
name: glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity
namespace: molecular_function
def:
  "Catalysis of the reaction: D-glyceraldehyde 3-phosphate + NAD+ + H2O = 3-phospho-D-glycerate + NADH + H+." [PMID:9497334]


id: GO:0043879
name: glycolate transmembrane transporter activity
namespace: molecular_function
def:
  "Enables the transfer of glycolate from one side of a membrane to the other. Glycolate is the smallest alpha-hydroxy acid (AHA)." [CHEBI:28905, GOC:jl]


id: GO:0043881
name: mesaconyl-CoA hydratase activity
namespace: molecular_function
def:
  "Catalysis of the hydration of mesaconyl-CoA to beta-methylmalyl-CoA." [PMID:16856935, PMID:16856937]


id: GO:0043882
name: malate:sodium symporter activity
namespace: molecular_function
def:
  "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: malate(out) + Na+(out) = malate(in) + Na+(in)." [GOC:jl, PMID:10903309]


id: GO:0043884
name: CO-methylating acetyl-CoA synthase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: acetyl-CoA + corrinoid protein = CO + methylcorrinoid protein + CoA." [EC:2.3.1.169, PMID:1748656]


id: GO:0043885
name: carbon-monoxide dehydrogenase (ferredoxin) activity
namespace: molecular_function
def:
  "Catalysis of the reaction: CO + H2O + oxidized ferredoxin = CO2 + reduced ferredoxin." [EC:1.2.7.4]


id: GO:0043886
name: structural constituent of carboxysome
namespace: molecular_function
def:
  "The action of a molecule that contributes to the structural integrity of a carboxysome, an organelle found in the Cyanobacteria consisting of a proteinaceous coat and enzymes for the fixation of carbon dioxide." [GOC:jl]


id: GO:0043887
name: melibiose:sodium symporter activity
namespace: molecular_function
def:
  "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: melibiose(out) + Na+(out) = melibiose(in) + Na+(in)." [PMID:1970646]


id: GO:0043888
name: (S)-2,3-di-O-geranylgeranylglyceryl phosphate synthase activity
namespace: molecular_function
def:
  "Catalysis of the transfer of a geranylgeranyl group from geranylgeranyl diphosphate to (S)-3-O-geranylgeranylglyceryl phosphate to form (S)-2,3-di-O-geranylgeranylglyceryl phosphate." [PMID:15356000, PMID:16494480]


id: GO:0043889
name: (S)-3-O-geranylgeranylglyceryl phosphate synthase activity
namespace: molecular_function
def:
  "Catalysis of the alkylation of the primary hydroxyl group in (S)-glyceryl phosphate by geranylgeranyl diphosphate to form (S)-3-O-geranylgeranylglyceryl phosphate." [PMID:12801917, PMID:17253090, PMID:8408023]


id: GO:0043890
name: N-acetylgalactosamine-6-sulfatase activity
namespace: molecular_function
def:
  "Catalysis of the hydrolysis of the 6-sulfate groups of the N-acetyl-D-galactosamine 6-sulfate units of chondroitin sulfate and of the D-galactose 6-sulfate units of keratan sulfate." [EC:3.1.6.4]


id: GO:0043891
name: glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating) activity
namespace: molecular_function
def:
  "Catalysis of the reaction: D-glyceraldehyde 3-phosphate + phosphate + NAD(P)+ = 3-phospho-D-glyceroyl phosphate + NAD(P)H + H+." [EC:1.2.1.59]


id: GO:0043893
name: acetate:cation symporter activity
namespace: molecular_function
def:
  "Catalysis of the transfer of acetate from one side of a membrane to the other according to the reaction: acetate(out) + cation(out) = acetate(in) + cation(in)." [GOC:jl]


id: GO:0043894
name: acetyl-CoA synthetase acetyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the acetylation of residue Lys609 of the enzyme acetyl-CoA synthetase, using acetyl-CoA as substrate." [PMID:15236963]


id: GO:0043895
name: cyclomaltodextrin glucanotransferase activity
namespace: molecular_function
def:
  "Catalysis of the cyclization of part of a 1,4-alpha-D-glucan chain by formation of a 1,4-alpha-D-glucosidic bond." [EC:2.4.1.19]


id: GO:0043896
name: glucan 1,6-alpha-glucosidase activity
namespace: molecular_function
def:
  "Catalysis of the hydrolysis of (1->6)-alpha-D-glucosidic linkages in (1->6)-alpha-D-glucans and derived oligosaccharides." [EC:3.2.1.70]


id: GO:0043897
name: glucan 1,4-alpha-maltohydrolase activity
namespace: molecular_function
def:
  "Catalysis of the hydrolysis of (1->4)-alpha-D-glucosidic linkages in polysaccharides so as to remove successive alpha-maltose residues from the non-reducing ends of the chains." [EC:3.2.1.133]


id: GO:0043898
name: 2,3-dihydroxybiphenyl 1,2-dioxygenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 2,3-dihydroxybiphenyl + O2 = 2-hydroxy-6-phenylhexa-2,4-dienoic acid." [GOC:jl, PMID:15715866]


id: GO:0043899
name: phosphoserine:homoserine phosphotransferase activity
namespace: molecular_function
def:
  "Catalysis of the transfer of a phosphoryl group from phosphoserine to homoserine to form phosphohomoserine." [GOC:jl, PMID:14699121]


id: GO:0043900
name: regulation of multi-organism process
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of a multi-organism process, a process in which an organism has an effect on another organism of the same or different species." [GOC:jl]


id: GO:0043901
name: negative regulation of multi-organism process
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of a multi-organism process, a process in which an organism has an effect on another organism of the same or different species." [GOC:jl]


id: GO:0043902
name: positive regulation of multi-organism process
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of a multi-organism process, a process in which an organism has an effect on another organism of the same or different species." [GOC:jl]


id: GO:0043903
name: regulation of symbiosis, encompassing mutualism through parasitism
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of symbiosis, an interaction between two organisms living together in more or less intimate association." [GOC:jl]


id: GO:0043908
name: Ser(Gly)-tRNA(Ala) hydrolase activity
namespace: molecular_function
def:
  "Catalysis of the hydrolysis of misacylated Ser-tRNA(Ala) and Gly-tRNA(Ala)." [GOC:jl, PMID:14663147]


id: GO:0043909
name: N-acetylcitrulline deacetylase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: N-acetyl-L-citrulline + H2O = citrulline + acetate." [GOC:jl, IMG:02799, PMID:16750290]


id: GO:0043910
name: ATP:coenzyme F420 adenylyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: ATP + factor gamma-F420-2 + H+ = coenzyme F390-A + diphosphate." [GOC:jl, IMG:02803, MetaCyc:RXN-9385, PMID:7957247, PMID:8550473]


id: GO:0043911
name: D-lysine transaminase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: D-lysine + 2-oxoglutarate = L-glutamate + 6-amino-2-oxohexanoate." [GOC:jl, IMG:02956, PMID:17259313]


id: GO:0043912
name: D-lysine oxidase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: D-lysine + O2 + H2O = 6-amino-2-oxohexanoate + NH3 + hydrogen peroxide." [GOC:jl, IMG:02957, PMID:17259313]


id: GO:0043913
name: chromosome segregation-directing complex
namespace: cellular_component
def:
  "A trimeric protein complex which in E. coli is composed of the subunits MreB, MreC and MreD. The complex directs longitudinal cell wall synthesis, maintaining cell morphology." [GOC:jl, PMID:15612918]


id: GO:0043914
name: NADPH:sulfur oxidoreductase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: NADPH + H+ + sulfur = hydrogen sulfide + NADP+." [GOC:jl, PMID:17449625]


id: GO:0043915
name: L-seryl-tRNA(Sec) kinase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: ATP + L-seryl-tRNA(Sec) = ADP + O-phospho-L-seryl-tRNA(Sec)." [GOC:jl, IMG:03019, PMID:16201757]


id: GO:0043916
name: DNA-7-methylguanine glycosylase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: DNA containing 7-methylguanine + H2O = DNA with abasic site + 7-methylguanine. This reaction is the hydrolysis of DNA by cleavage of the N-C1' glycosidic bond between the damaged DNA 7-methylguanine and the deoxyribose sugar to remove the 7-methylguanine, leaving an abasic site." [GOC:jl, PMID:16468998]


id: GO:0043917
name: ribose 1,5-bisphosphate isomerase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: D-ribose 1,5-bisphosphate = D-ribulose 1,5-bisphosphate." [GOC:jl, IMG:03024]


id: GO:0043918
name: cadaverine aminopropyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: S-adenosylmethioninamine + cadaverine = 5'-methylthioadenosine + N-(3-aminopropyl)cadaverine." [GOC:jl, IMG:00522, PMID:17545282]


id: GO:0043919
name: agmatine aminopropyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: agmatine + S-adenosylmethioninamine = N1-aminopropylagmatine + 5'-methylthioadenosine." [GOC:jl, IMG:03077, PMID:15983049]


id: GO:0043920
name: aminopropylagmatine ureohydrolase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: N1-aminopropylagmatine + H2O = spermidine + urea." [GOC:jl, IMG:03079, PMID:15983049]


id: GO:0043921
name: modulation by host of viral transcription
namespace: biological_process
def:
  "Any process in which a host organism modulates the frequency, rate or extent of viral transcription." [GOC:jl]


id: GO:0043922
name: negative regulation by host of viral transcription
namespace: biological_process
def:
  "Any process in which a host organism stops, prevents, or reduces the frequency, rate or extent of viral transcription." [GOC:jl]


id: GO:0043923
name: positive regulation by host of viral transcription
namespace: biological_process
def:
  "Any process in which a host organism activates or increases the frequency, rate or extent of viral transcription, the synthesis of either RNA on a template of DNA or DNA on a template of RNA." [GOC:jl]


id: GO:0043924
name: suramin binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with suramin, a naphthalenesulfonic acid compound which is used in the treatment of diseases caused by trypanosomes and worms." [CHEBI:45906, GOC:jl, Wikipedia:Suramin]


id: GO:0043927
namespace: biological_process
name:
  exonucleolytic nuclear-transcribed mRNA catabolic process involved in endonucleolytic cleavage-dependent decay

def:
  "The chemical reactions and pathways resulting in the breakdown of the transcript body of a nuclear-transcribed mRNA that occurs when the ends are not protected by the 5'-cap." [GOC:mtg_mpo]


id: GO:0043928
name: exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the breakdown of the transcript body of a nuclear-transcribed mRNA that occurs when the ends are not protected by the 3'-poly(A) tail." [GOC:mtg_mpo]


id: GO:0043929
name: primary ovarian follicle growth involved in double layer follicle stage
namespace: biological_process
def:
  "Increase in size of primary follicles including oocyte growth and granulosa and/or theca cell proliferation until more than one layer of granulosa cells is present (preantral follicle), as part of the double layer follicle stage of oogenesis." [GOC:mtg_mpo]


id: GO:0043930
name: primary ovarian follicle growth involved in primary follicle stage
namespace: biological_process
def:
  "Increase in size of primary follicles including oocyte growth and granulosa and/or theca cell proliferation until more than one layer of granulosa cells is present (preantral follicle) as part of the primary follicle stage of oogenesis." [GOC:mtg_mpo]


id: GO:0043931
name: ossification involved in bone maturation
namespace: biological_process
def:
  "The formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone, involved in the progression of the skeleton from its formation to its mature state." [GOC:dph, GOC:mah, GOC:mtg_mpo]


id: GO:0043932
name: ossification involved in bone remodeling
namespace: biological_process
def:
  "The formation or growth of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone, involved in response to injury or other physical, physiological or environmental stress stimuli." [GO_REF:0000034, GOC:mtg_mpo]


id: GO:0043933
name: macromolecular complex subunit organization
namespace: biological_process
def:
  "Any process in which macromolecules aggregate, disaggregate, or are modified, resulting in the formation, disassembly, or alteration of a macromolecular complex." [GOC:mtg_mpo]


id: GO:0043934
name: sporulation
namespace: biological_process
def:
  "The process whose specific outcome is the progression of a spore over time, from its initiation to the mature structure. A spore is a structure that can be used for dissemination, for survival of adverse conditions because of its heat and dessication resistance, and/or for reproduction." [GOC:pamgo_curators]


id: GO:0043935
name: sexual sporulation resulting in formation of a cellular spore
namespace: biological_process
def:
  "The formation of spores derived from the products of meiosis. A cellular spore is a cell form that can be used for dissemination, for survival of adverse conditions because of its heat and dessication resistance, and/or for reproduction." [GOC:pamgo_curators]


id: GO:0043936
name: asexual sporulation resulting in formation of a cellular spore
namespace: biological_process
def:
  "The formation of a cellular spore derived from the products of mitosis. A cellular spore is a cell form that can be used for dissemination, for survival of adverse conditions because of its heat and dessication resistance, and/or for reproduction." [GOC:pamgo_curators]


id: GO:0043937
name: regulation of sporulation
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of sporulation, the process whose specific outcome is the progression of a spore over time, from its initiation to the mature structure." [GOC:pamgo_curators]


id: GO:0043938
name: positive regulation of sporulation
namespace: biological_process
def:
  "Any process that activates, maintains or increases the frequency, rate or extent of sporulation, the process whose specific outcome is the progression of a spore over time, from its initiation to the mature structure." [GOC:pamgo_curators]


id: GO:0043939
name: negative regulation of sporulation
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of sporulation, the process whose specific outcome is the progression of a spore over time, from its initiation to the mature structure." [GOC:pamgo_curators]


id: GO:0043940
name: regulation of sexual sporulation resulting in formation of a cellular spore
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of the formation of cellular spores derived from the products of meiosis." [GOC:pamgo_curators]


id: GO:0043941
name: positive regulation of sexual sporulation resulting in formation of a cellular spore
namespace: biological_process
def:
  "Any process that activates, maintains or increases the frequency, rate or extent of the formation of cellular spores derived from the products of meiosis." [GOC:pamgo_curators]


id: GO:0043942
name: negative regulation of sexual sporulation resulting in formation of a cellular spore
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of the formation of cellular spores derived from the products of meiosis." [GOC:pamgo_curators]


id: GO:0043943
name: regulation of asexual sporulation resulting in formation of a cellular spore
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of the formation of a cellular spore derived from the products of mitosis." [GOC:pamgo_curators]


id: GO:0043944
name: negative regulation of asexual sporulation resulting in formation of a cellular spore
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of the formation of a cellular spore derived from the products of mitosis." [GOC:pamgo_curators]


id: GO:0043945
name: positive regulation of asexual sporulation resulting in formation of a cellular spore
namespace: biological_process
def:
  "Any process that activates, maintains or increases the frequency, rate or extent of the formation of a cellular spore derived from the products of mitosis." [GOC:pamgo_curators]


id: GO:0043946
name: positive regulation of catalytic activity in other organism involved in symbiotic interaction
namespace: biological_process
def:
  "Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of enzyme activity in a second organism, where the two organisms are in a symbiotic interaction." [GOC:mtg_pamgo_17jul06, GOC:tb]


id: GO:0043947
name: positive regulation by host of symbiont catalytic activity
namespace: biological_process
def:
  "Any process in which an organism activates, maintains or increases the frequency, rate or extent of symbiont enzyme activity. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]


id: GO:0043948
name: positive regulation by symbiont of host catalytic activity
namespace: biological_process
def:
  "Any process in which the symbiont activates, maintains or increases the frequency, rate or extent of host enzyme activity. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]


id: GO:0043949
name: regulation of cAMP-mediated signaling
namespace: biological_process
def:
  "Any process which modulates the frequency, rate or extent of cAMP-mediated signaling, a series of molecular signals in which a cell uses cyclic AMP to convert an extracellular signal into a response." [GOC:jl]


id: GO:0043950
name: positive regulation of cAMP-mediated signaling
namespace: biological_process
def:
  "Any process which activates, maintains or increases the frequency, rate or extent of cAMP-mediated signaling, a series of molecular signals in which a cell uses cyclic AMP to convert an extracellular signal into a response." [GOC:jl]


id: GO:0043951
name: negative regulation of cAMP-mediated signaling
namespace: biological_process
def:
  "Any process which stops, prevents, or reduces the frequency, rate or extent of cAMP-mediated signaling, a series of molecular signals in which a cell uses cyclic AMP to convert an extracellular signal into a response." [GOC:jl]


id: GO:0043952
name: protein transport by the Sec complex
namespace: biological_process
def:
  "The process in which unfolded proteins are transported across the cytoplasmic membrane in Gram-positive and Gram-negative bacteria by the Sec complex, in a process involving proteolytic cleavage of an N-terminal signal peptide." [GOC:pamgo_curators]


id: GO:0043953
name: protein transport by the Tat complex
namespace: biological_process
def:
  "The process in which folded proteins are transported across cytoplasmic membranes of bacteria and membranes of organelles derived from bacteria (chloroplasts and mitochondria) by the TAT complex." [GOC:pamgo_curators]


id: GO:0043954
name: cellular component maintenance
namespace: biological_process
def:
  "The organization process that preserves a cellular component in a stable functional or structural state." [GOC:dph, GOC:jl, GOC:mah]


id: GO:0043955
name: 3-hydroxypropionyl-CoA synthetase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 3-hydroxypropionate + ATP + CoA = 3-hydroxypropionyl-CoA + AMP + diphosphate." [GOC:jl, PMID:11821399]


id: GO:0043957
name: acryloyl-CoA reductase (NADP+) activity
namespace: molecular_function
def:
  "Catalysis of the reaction: acryloyl-CoA + NADPH + H+ = propionyl-CoA + NADP+." [GOC:jl, PMID:11821399]


id: GO:0043958
name: acryloyl-CoA reductase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: acryloyl-CoA + NADH + H+ + a reduced electron-transfer flavoprotein = propionyl-CoA + NAD+ + an oxidized electron-transfer flavoprotein." [GOC:jl, PMID:12603323]


id: GO:0043959
name: L-erythro-3-methylmalyl-CoA lyase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: propionyl-CoA + glyoxylate = L-erythro-3-methylmalyl-CoA." [GOC:jl, IMG:03303]


id: GO:0043961
name: succinyl-CoA:(R)-citramalate CoA-transferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: succinyl-CoA + (R)-citramalate = succinate + (R)-citramalyl-CoA." [GOC:jl, IMG:03306, PMID:17259315]


id: GO:0043962
name: negative regulation by host of symbiont adenylate cyclase-mediated signal transduction
namespace: biological_process
def:
  "Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of adenylate cyclase-mediated signal transduction in the symbiont organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]


id: GO:0043963
name: modulation by symbiont of host adenylate cyclase-mediated signal transduction
namespace: biological_process
def:
  "Any process in which the symbiont modulates the frequency, rate or extent of adenylate cyclase-mediated signal transduction in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]


id: GO:0043964
name: positive regulation by symbiont of host adenylate cyclase-mediated signal transduction
namespace: biological_process
def:
  "Any process in which an organism activates, maintains or increases the frequency, rate or extent of adenylate cyclase-mediated signal transduction in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]


id: GO:0043965
name: negative regulation by symbiont of host adenylate cyclase-mediated signal transduction
namespace: biological_process
def:
  "Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of adenylate cyclase-mediated signal transduction in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]


id: GO:0043970
name: histone H3-K9 acetylation
namespace: biological_process
def:
  "The modification of histone H3 by the addition of an acetyl group to a lysine residue at position 9 of the histone." [GOC:jl]


id: GO:0043971
name: histone H3-K18 acetylation
namespace: biological_process
def:
  "The modification of histone H3 by the addition of an acetyl group to a lysine residue at position 18 of the histone." [GOC:jl]


id: GO:0043972
name: histone H3-K23 acetylation
namespace: biological_process
def:
  "The modification of histone H3 by the addition of an acetyl group to a lysine residue at position 23 of the histone." [GOC:jl]


id: GO:0043973
name: histone H3-K4 acetylation
namespace: biological_process
def:
  "The modification of histone H3 by the addition of an acetyl group to a lysine residue at position 4 of the histone." [GOC:jl]


id: GO:0043974
name: histone H3-K27 acetylation
namespace: biological_process
def:
  "The modification of histone H3 by the addition of an acetyl group to a lysine residue at position 27 of the histone." [GOC:jl]


id: GO:0043975
name: histone H3-K36 acetylation
namespace: biological_process
def:
  "The modification of histone H3 by the addition of an acetyl group to a lysine residue at position 36 of the histone." [GOC:jl]


id: GO:0043976
name: histone H3-K79 acetylation
namespace: biological_process
def:
  "The modification of histone H3 by the addition of an acetyl group to a lysine residue at position 79 of the histone." [GOC:jl]


id: GO:0043977
name: histone H2A-K5 acetylation
namespace: biological_process
def:
  "The modification of histone H2A by the addition of an acetyl group to a lysine residue at position 5 of the histone." [GOC:jl]


id: GO:0043978
name: histone H2A-K9 acetylation
namespace: biological_process
def:
  "The modification of histone H2A by the addition of an acetyl group to a lysine residue at position 9 of the histone." [GOC:jl]


id: GO:0043979
name: histone H2B-K5 acetylation
namespace: biological_process
def:
  "The modification of histone H2B by the addition of an acetyl group to a lysine residue at position 5 of the histone." [GOC:jl]


id: GO:0043980
name: histone H2B-K12 acetylation
namespace: biological_process
def:
  "The modification of histone H2B by the addition of an acetyl group to a lysine residue at position 12 of the histone." [GOC:jl]


id: GO:0043981
name: histone H4-K5 acetylation
namespace: biological_process
def:
  "The modification of histone H4 by the addition of an acetyl group to a lysine residue at position 5 of the histone." [GOC:jl]


id: GO:0043982
name: histone H4-K8 acetylation
namespace: biological_process
def:
  "The modification of histone H4 by the addition of an acetyl group to a lysine residue at position 8 of the histone." [GOC:jl]


id: GO:0043983
name: histone H4-K12 acetylation
namespace: biological_process
def:
  "The modification of histone H4 by the addition of an acetyl group to a lysine residue at position 12 of the histone." [GOC:jl]


id: GO:0043984
name: histone H4-K16 acetylation
namespace: biological_process
def:
  "The modification of histone H4 by the addition of an acetyl group to a lysine residue at position 16 of the histone." [GOC:jl]


id: GO:0043985
name: histone H4-R3 methylation
namespace: biological_process
def:
  "The modification of histone H4 by addition of a methyl group to arginine at position 3 of the histone." [GOC:mah]


id: GO:0043987
name: histone H3-S10 phosphorylation
namespace: biological_process
def:
  "The modification of histone H3 by the addition of an phosphate group to a serine residue at position 10 of the histone." [GOC:jl]


id: GO:0043988
name: histone H3-S28 phosphorylation
namespace: biological_process
def:
  "The modification of histone H3 by the addition of an phosphate group to a serine residue at position 28 of the histone." [GOC:jl]


id: GO:0043989
name: histone H4-S1 phosphorylation
namespace: biological_process
def:
  "The modification of histone H4 by the addition of an phosphate group to a serine residue at position 1 of the histone." [GOC:jl]


id: GO:0043990
name: histone H2A-S1 phosphorylation
namespace: biological_process
def:
  "The modification of histone H2A by the addition of an phosphate group to a serine residue at position 1 of the histone." [GOC:jl]


id: GO:0043991
name: histone H2B-S14 phosphorylation
namespace: biological_process
def:
  "The modification of histone H2B by the addition of an phosphate group to a serine residue at position 14 of the histone." [GOC:jl]


id: GO:0043992
name: histone acetyltransferase activity (H3-K9 specific)
namespace: molecular_function
def:
  "Catalysis of the reaction: acetyl-CoA + histone H3 L-lysine (position 9) = CoA + histone H3 N6-acetyl-L-lysine (position 9)." [EC:2.3.1.48]


id: GO:0043993
name: histone acetyltransferase activity (H3-K18 specific)
namespace: molecular_function
def:
  "Catalysis of the reaction: acetyl-CoA + histone H3 L-lysine (position 18) = CoA + histone H3 N6-acetyl-L-lysine (position 18)." [EC:2.3.1.48]


id: GO:0043994
name: histone acetyltransferase activity (H3-K23 specific)
namespace: molecular_function
def:
  "Catalysis of the reaction: acetyl-CoA + histone H3 L-lysine (position 23) = CoA + histone H3 N6-acetyl-L-lysine (position 23)." [EC:2.3.1.48]


id: GO:0043995
name: histone acetyltransferase activity (H4-K5 specific)
namespace: molecular_function
def:
  "Catalysis of the reaction: acetyl-CoA + histone H4 L-lysine (position 5) = CoA + histone H4 N6-acetyl-L-lysine (position 5)." [EC:2.3.1.48]


id: GO:0043996
name: histone acetyltransferase activity (H4-K8 specific)
namespace: molecular_function
def:
  "Catalysis of the reaction: acetyl-CoA + histone H4 L-lysine (position 8) = CoA + histone H4 N6-acetyl-L-lysine (position 8)." [EC:2.3.1.48]


id: GO:0043997
name: histone acetyltransferase activity (H4-K12 specific)
namespace: molecular_function
def:
  "Catalysis of the reaction: acetyl-CoA + histone H4 L-lysine (position 12) = CoA + histone H4 N6-acetyl-L-lysine (position 12)." [EC:2.3.1.48]


id: GO:0043998
name: H2A histone acetyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: acetyl-CoA + histone H2A L-lysine = CoA + histone H2A N6-acetyl-L-lysine." [EC:2.3.1.48]


id: GO:0043999
name: histone acetyltransferase activity (H2A-K5 specific)
namespace: molecular_function
def:
  "Catalysis of the reaction: acetyl-CoA + histone H2A L-lysine (position 5) = CoA + histone H2A N6-acetyl-L-lysine (position 5)." [EC:2.3.1.48]


id: GO:0044000
name: movement in host
namespace: biological_process
def:
  "The process in which an organism or its progeny spreads from one location to another within its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:cc]


id: GO:0044001
name: migration in host
namespace: biological_process
def:
  "The directional movement of an organism from one place to another within its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:cc]


id: GO:0044002
name: acquisition of nutrients from host
namespace: biological_process
def:
  "The process that begins with the production and formation of structures and molecules in an organism that are required for the acquisition and utilization of nutrients from its host organism, and the ends with the acquirement of the nutrients. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:cc, GOC:jl]


id: GO:0044003
name: modification by symbiont of host morphology or physiology
namespace: biological_process
def:
  "The process in which a symbiont organism effects a change in the structure or processes of its host organism." [GOC:cc]


id: GO:0044004
name: disruption by symbiont of host cell
namespace: biological_process
def:
  "Any process in which an organism has a negative effect on the functioning of the host's cells. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:cc]


id: GO:0044005
name: induction by symbiont in host of tumor, nodule, or growth
namespace: biological_process
def:
  "The process in which an organism causes the formation of a mass of cells in its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:cc]


id: GO:0044006
name: induction by symbiont in host of tumor, nodule, or growth containing transformed cells
namespace: biological_process
def:
  "The process in which an organism causes the formation in its host organism of a growth whose cells have been transformed and continue to exist in the absence of the first organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:cc]


id: GO:0044007
name: dissemination or transmission of symbiont from host
namespace: biological_process
def:
  "The movement of an organism from a host to another host or from a host to another place in the environment. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:cc]


id: GO:0044008
name: dissemination or transmission of symbiont from host by vector
namespace: biological_process
def:
  "The movement of an organism from one host to another (or another place in the environment) by means of a third organism (often an insect or other animal). The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:cc]


id: GO:0044009
name: viral transmission by vector
namespace: biological_process
def:
  "The transfer of virions by means of an organism (often an insect or other animal) in order to create new infection." [GOC:cc]


id: GO:0044010
name: single-species biofilm formation
namespace: biological_process
def:
  "A process in which planktonically growing microorganisms of the same species grow at a liquid-air interface or on a solid substrate under the flow of a liquid and produce extracellular polymers that facilitate matrix formation, resulting in a change in the organisms' growth rate and gene transcription." [GOC:cc, GOC:di, GOC:tb]


id: GO:0044011
name: single-species biofilm formation on inanimate substrate
namespace: biological_process
def:
  "A process in which microorganisms of the same species attach to and grow on an inanimate surface such as a rock or pipe, and produce extracellular polymers that facilitate attachment and matrix formation, resulting in an alteration in the phenotype of the organisms with respect to growth rate and gene transcription." [GOC:cc]


id: GO:0044012
name: histone acetyltransferase activity (H2A-K9 specific)
namespace: molecular_function
def:
  "Catalysis of the reaction: acetyl-CoA + histone H2A L-lysine (position 9) = CoA + histone H2A N6-acetyl-L-lysine (position 9)." [EC:2.3.1.48]


id: GO:0044013
name: H2B histone acetyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: acetyl-CoA + histone H2B L-lysine = CoA + histone H2B N6-acetyl-L-lysine." [EC:2.3.1.48]


id: GO:0044014
name: histone acetyltransferase activity (H2B-K5 specific)
namespace: molecular_function
def:
  "Catalysis of the reaction: acetyl-CoA + histone H2B L-lysine (position 5) = CoA + histone H2B N6-acetyl-L-lysine (position 5)." [EC:2.3.1.48]


id: GO:0044015
name: histone acetyltransferase activity (H2B-K12 specific)
namespace: molecular_function
def:
  "Catalysis of the reaction: acetyl-CoA + histone H2B L-lysine (position 12) = CoA + histone H2B N6-acetyl-L-lysine (position 12)." [EC:2.3.1.48]


id: GO:0044016
name: histone acetyltransferase activity (H3-K4 specific)
namespace: molecular_function
def:
  "Catalysis of the reaction: acetyl-CoA + histone H3 L-lysine (position 4) = CoA + histone H3 N6-acetyl-L-lysine (position 4)." [EC:2.3.1.48]


id: GO:0044017
name: histone acetyltransferase activity (H3-K27 specific)
namespace: molecular_function
def:
  "Catalysis of the reaction: acetyl-CoA + histone H3 L-lysine (position 27) = CoA + histone H3 N6-acetyl-L-lysine (position 27)." [EC:2.3.1.48]


id: GO:0044018
name: histone acetyltransferase activity (H3-K36 specific)
namespace: molecular_function
def:
  "Catalysis of the reaction: acetyl-CoA + histone H3 L-lysine (position 36) = CoA + histone H3 N6-acetyl-L-lysine (position 36)." [EC:2.3.1.48]


id: GO:0044019
name: histone acetyltransferase activity (H3-K72 specific)
namespace: molecular_function
def:
  "Catalysis of the reaction: acetyl-CoA + histone H3 L-lysine (position 72) = CoA + histone H3 N6-acetyl-L-lysine (position 72)." [EC:2.3.1.48]


id: GO:0044020
name: histone methyltransferase activity (H4-R3 specific)
namespace: molecular_function
def:
  "Catalysis of the reaction: S-adenosyl-L-methionine + (histone H4)-arginine (position 3) = S-adenosyl-L-homocysteine + (histone H4)-N-methyl-arginine (position 3). This reaction is the addition of a methyl group to arginine at position 3 of histone H4." [EC:2.1.1.125, GOC:mah, PMID:17898714]


id: GO:0044022
name: histone kinase activity (H3-S28 specific)
namespace: molecular_function
def:
  "Catalysis of the transfer of a phosphate group to the serine-28 residue of the N-terminal tail of histone H3." [GOC:jl]


id: GO:0044023
name: histone kinase activity (H4-S1 specific)
namespace: molecular_function
def:
  "Catalysis of the transfer of a phosphate group to the serine-1 residue of the N-terminal tail of histone H4." [GOC:jl]


id: GO:0044024
name: histone kinase activity (H2A-S1 specific)
namespace: molecular_function
def:
  "Catalysis of the transfer of a phosphate group to the serine-1 residue of the N-terminal tail of histone H2A." [GOC:jl]


id: GO:0044025
name: histone kinase activity (H2B-S14 specific)
namespace: molecular_function
def:
  "Catalysis of the transfer of a phosphate group to the serine-14 or an equivalent residue of the N-terminal tail of histone H2B." [GOC:jl]


id: GO:0044026
name: DNA hypermethylation
namespace: biological_process
def:
  "An increase in the epigenetic methylation of cytosine and adenosine residues in DNA." [GOC:jl, http://en.wiktionary.org/]


id: GO:0044027
name: hypermethylation of CpG island
namespace: biological_process
def:
  "An increase in the epigenetic methylation of cytosine and adenosine residues in a CpG island in DNA. CpG islands are genomic regions that contain a high frequency of the CG dinucleotide and are often associated with the transcription start site of genes." [GOC:jl, Wikipedia:Cpg_island]


id: GO:0044028
name: DNA hypomethylation
namespace: biological_process
def:
  "An decrease in the epigenetic methylation of cytosine and adenosine residues in DNA." [GOC:jl, http://en.wiktionary.org/hypomethylation]


id: GO:0044029
name: hypomethylation of CpG island
namespace: biological_process
def:
  "An decrease in the epigenetic methylation of cytosine and adenosine residues in a CpG island in DNA. CpG islands are genomic regions that contain a high frequency of the CG dinucleotide and are often associated with the transcription start site of genes." [GOC:jl, Wikipedia:Cpg_island]


id: GO:0044030
name: regulation of DNA methylation
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of the covalent transfer of a methyl group to either N-6 of adenine or C-5 or N-4 of cytosine." [GOC:jl]


id: GO:0044031
name: modification by symbiont of host protein by phosphorylation
namespace: biological_process
def:
  "The process in which an organism adds a phosphate group to a protein of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]


id: GO:0044032
name: modulation by symbiont of indole acetic acid levels in host
namespace: biological_process
def:
  "The alteration by an organism of the levels of indole acetic acid in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]


id: GO:0044033
name: multi-organism metabolic process
namespace: biological_process
def:
  "A metabolic process - chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances - which involves more than one organism." [GOC:jl]


id: GO:0044034
name: multi-organism biosynthetic process
namespace: biological_process
def:
  "A biosynthetic process - chemical reactions and pathways resulting in the formation of substances - which involves more than one organism." [GOC:jl]


id: GO:0044035
name: multi-organism catabolic process
namespace: biological_process
def:
  "A catabolic process - chemical reactions and pathways resulting in the breakdown of substances - which involves more than one organism." [GOC:jl]


id: GO:0044036
name: cell wall macromolecule metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving macromolecules forming, or destined to form, part of the cell wall. A cell wall is a rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis." [GOC:jl, GOC:mah]


id: GO:0044037
name: multi-organism cell wall macromolecule metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving macromolecules forming, or destined to form, part of a cell wall, involving more than one organism. A cell wall is a rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis." [GOC:mah, GOC:tair_curators]


id: GO:0044038
name: cell wall macromolecule biosynthetic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of a macromolecule destined to form part of a cell wall." [GOC:go_curators]


id: GO:0044040
name: multi-organism carbohydrate metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, that involve more than one organism." [GOC:jl]


id: GO:0044041
name: multi-organism carbohydrate catabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the breakdown of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, involving more than one organism." [GOC:jl]


id: GO:0044042
name: glucan metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving glucans, polysaccharides consisting only of glucose residues." [GOC:jl]


id: GO:0044043
name: multi-organism glucan metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving glucans, polysaccharides consisting only of glucose residues, involving more than one organism." [ISBN:0198547684]


id: GO:0044044
name: interaction with host via substance in symbiont surface
namespace: biological_process
def:
  "An interaction with the host organism mediated by a substance on the surface of the other (symbiont) organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [MITRE:tk]


id: GO:0044045
name: interaction with host via substance in symbiont cell outer membrane
namespace: biological_process
def:
  "An interaction with the host organism mediated by a substance in the symbiont cell outer membrane - a lipid bilayer that forms the outermost layer of the symbiont cell envelope. The host is defined as the larger of the organisms involved in a symbiotic interaction." [MITRE:tk]


id: GO:0044046
name: interaction with host via substance released outside of symbiont
namespace: biological_process
def:
  "An interaction with the host organism mediated by a substance that is released by the other organism. This includes substances that are released via pathogen cell lysis." [MITRE:tk]


id: GO:0044047
name: interaction with host via protein secreted by type I secretion system
namespace: biological_process
def:
  "An interaction with the host organism mediated by a substance secreted by the other (symbiont) organism via a type I secretion system. The host is defined as the larger of the organisms involved in a symbiotic interaction." [MITRE:tk]


id: GO:0044048
name: interaction with host via protein secreted by type V secretion system
namespace: biological_process
def:
  "An interaction with the host organism mediated by a substance secreted by the other (symbiont) organism via a type V secretion system. The host is defined as the larger of the organisms involved in a symbiotic interaction." [MITRE:tk]


id: GO:0044049
name: interaction with host via protein secreted by type VI secretion system
namespace: biological_process
def:
  "An interaction with the host organism mediated by a substance secreted by the other (symbiont) organism via a type VI secretion system. The host is defined as the larger of the organisms involved in a symbiotic interaction." [MITRE:tk]


id: GO:0044050
name: interaction with host via substance released by sporangium lysis
namespace: biological_process
def:
  "An interaction with the host organism mediated by a substance released via rupture of symbiont sporangia, structures producing and containing spores. The host is defined as the larger of the organisms involved in a symbiotic interaction." [MITRE:tk]


id: GO:0044051
name: interaction with host via substance released by symbiont cytolysis
namespace: biological_process
def:
  "An interaction with the host organism mediated by a substance released via cytolysis of symbiont cells. Cytolysis is the rupture of cell membranes and the loss of cytoplasm. The host is defined as the larger of the organisms involved in a symbiotic interaction." [MITRE:tk]


id: GO:0044052
name: interaction with host via substance released by membrane budding
namespace: biological_process
def:
  "An interaction with the host organism mediated by a substance released via symbiont membrane budding, the evagination of a membrane resulting in formation of a vesicle." [MITRE:tk]


id: GO:0044053
name: translocation of peptides or proteins into host cell cytoplasm
namespace: biological_process
def:
  "The directed movement of peptides or proteins produced by a symbiont organism to a location within the host cell cytoplasm." [MITRE:tk]


id: GO:0044055
name: modulation by symbiont of host system process
namespace: biological_process
def:
  "The alteration by a symbiont organism of the functioning of a system process in the host. A system process is a multicellular organismal process carried out by any of the organs or tissues in an organ system." [MITRE:tk]


id: GO:0044056
name: modulation by symbiont of host digestive system process
namespace: biological_process
def:
  "The alteration by a symbiont organism of the functioning of a digestive system process, a physical, chemical, or biochemical process carried out by the host organism to break down ingested nutrients into components that may be easily absorbed and directed into metabolism." [MITRE:tk]


id: GO:0044057
name: regulation of system process
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of a system process, a multicellular organismal process carried out by any of the organs or tissues in an organ system." [GOC:jl]


id: GO:0044058
name: regulation of digestive system process
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of a digestive system process, a physical, chemical, or biochemical process carried out by living organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism." [GOC:jl]


id: GO:0044059
name: modulation by symbiont of host endocrine process
namespace: biological_process
def:
  "The alteration by a symbiont organism of the functioning of a endocrine process, any of the hormonal, neural, and secretory processes that release products into the blood or lymph, in the host organism." [MITRE:tk]


id: GO:0044060
name: regulation of endocrine process
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of an endocrine process, a process involving the secretion of or response to endocrine hormones. An endocrine hormone is a hormone released into the circulatory system." [GOC:jl]


id: GO:0044061
name: modulation by symbiont of host excretion
namespace: biological_process
def:
  "The alteration by a symbiont organism of the functioning of excretion, the elimination by the host organism of the waste products that arise as a result of metabolic activity." [MITRE:tk]


id: GO:0044062
name: regulation of excretion
namespace: biological_process
def:
  "Any process that modulates the frequency, rate, or extent of excretion, the elimination by an organism of the waste products that arise as a result of metabolic activity." [GOC:jl]


id: GO:0044063
name: modulation by symbiont of host neurological system process
namespace: biological_process
def:
  "The alteration by a symbiont organism of the functioning of a host neurophysiological process, an organ system process carried out by any of the organs or tissues of neurological system." [MITRE:tk]


id: GO:0044064
name: modulation by symbiont of host respiratory system process
namespace: biological_process
def:
  "The alteration by a symbiont organism of the functioning of a respiratory system process, an organ system process carried out by any of the organs or tissues of the respiratory system." [MITRE:tk]


id: GO:0044065
name: regulation of respiratory system process
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of a respiratory system process, an organ system process carried out by any of the organs or tissues of the respiratory system." [GOC:jl]


id: GO:0044066
name: modification by symbiont of host cell nucleus
namespace: biological_process
def:
  "The process in which a symbiont organism effects a change in the structure or function of its host cell nucleus." [MITRE:tk]


id: GO:0044067
name: modification by symbiont of host intercellular junctions
namespace: biological_process
def:
  "The process in which a symbiont organism effects a change in the structure or function of its host intercellular junction, a specialized region of connection between two cells." [MITRE:tk]


id: GO:0044068
name: modulation by symbiont of host cellular process
namespace: biological_process
def:
  "Any process in which a symbiont organism modulates the frequency, rate or extent of a cellular process, any process that is carried out at the cellular level, but not necessarily restricted to a single cell, in its host organism." [MITRE:tk]


id: GO:0044069
name: modulation by symbiont of host anion transport
namespace: biological_process
def:
  "The process in which a symbiont organism modulates the anion transport, the directed movement of anions, atoms or small molecules with a net negative charge, into, out of or within a cell, or between cells, of its host organism." [MITRE:tk]


id: GO:0044070
name: regulation of anion transport
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of the directed movement of anions, atoms or small molecules with a net negative charge into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl]


id: GO:0044071
name: modulation by symbiont of host cell cycle
namespace: biological_process
def:
  "The process in which a symbiont organism effects a change in its host's cell cycle through direct interactions with the host cell macromolecular machinery." [MITRE:tk]


id: GO:0044072
name: negative regulation by symbiont of host cell cycle
namespace: biological_process
def:
  "The process in which a symbiont organism stops, prevents or reduces the rate or extent of its host's progression through its cell cycle via direct interactions with the host cell macromolecular machinery." [MITRE:tk]


id: GO:0044073
name: modulation by symbiont of host translation
namespace: biological_process
def:
  "The process in which a symbiont organism effects a change in translation, the chemical reactions and pathways resulting in the formation of a protein, in its host organism." [MITRE:tk]


id: GO:0044074
name: negative regulation by symbiont of host translation
namespace: biological_process
def:
  "The process in which a symbiont organism stops, prevents, or reduces the frequency, rate or extent of translation, the chemical reactions and pathways resulting in the formation of a protein, in its host organism." [MITRE:tk]


id: GO:0044075
name: modulation by symbiont of host vacuole organization
namespace: biological_process
def:
  "Any process in which a symbiont organism modulates the frequency, rate or extent of vacuole organization in its host organism." [MITRE:tk]


id: GO:0044076
name: positive regulation by symbiont of host vacuole organization
namespace: biological_process
def:
  "The process in which a symbiont organism activates or increases the frequency, rate or extent of vacuole organization in its host organism." [MITRE:tk]


id: GO:0044077
name: modulation by symbiont of host receptor-mediated endocytosis
namespace: biological_process
def:
  "The process in which a symbiont organism modulates the frequency, rate or extent of receptor mediated endocytosis, the uptake of external materials by cells, utilizing receptors to ensure specificity of transport, in its host organism." [MITRE:tk]


id: GO:0044078
name: positive regulation by symbiont of host receptor-mediated endocytosis
namespace: biological_process
def:
  "Any process in which a symbiont organism activates or increases the frequency, rate or extent of receptor mediated endocytosis, the uptake of external materials by cells, utilizing receptors to ensure specificity of transport, in its host organism." [MITRE:tk]


id: GO:0044079
name: modulation by symbiont of host neurotransmitter secretion
namespace: biological_process
def:
  "Any process in which a symbiont organism modulates the frequency, rate or extent of the regulated release of a neurotransmitter from a cell in its host organism." [MITRE:tk]


id: GO:0044080
name: modulation by symbiont of host cGMP-mediated signal transduction
namespace: biological_process
def:
  "Any process in which a symbiont organism modulates the rate, frequency or extent of cGMP-mediated signaling in its host organism. cGMP-mediated signaling is a series of molecular signals in which a cell uses cyclic GMP to convert an extracellular signal into a response." [MITRE:tk]


id: GO:0044081
name: modulation by symbiont of host nitric oxide-mediated signal transduction
namespace: biological_process
def:
  "Any process in which a symbiont organism modulates the rate, frequency or extent of nitric oxide mediated signal transduction in its host organism. Nitric oxide mediated signal transduction is a series of molecular signals mediated by the detection of nitric oxide (NO)." [MITRE:tk]


id: GO:0044082
name: modulation by symbiont of host small GTPase mediated signal transduction
namespace: biological_process
def:
  "Any process in which a symbiont organism modulates the frequency, rate or extent of small GTPase mediated signal transduction in its host organism." [MITRE:tk]


id: GO:0044083
name: modulation by symbiont of host Rho protein signal transduction
namespace: biological_process
def:
  "Any process in which a symbiont organism modulates the frequency, rate or extent of Rho protein signal transduction in its host organism." [MITRE:tk]


id: GO:0044084
name: host cell membrane pore complex
namespace: cellular_component
def:
  "Any small opening in a host cell membrane that allows the passage of gases and/or liquids, composed of host proteins." [MITRE:tk]


id: GO:0044085
name: cellular component biogenesis
namespace: biological_process
def:
  "A process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cellular component. Includes biosynthesis of constituent macromolecules, and those macromolecular modifications that are involved in synthesis or assembly of the cellular component." [GOC:jl, GOC:mah]


id: GO:0044087
name: regulation of cellular component biogenesis
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of cellular component biogenesis, a process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cellular component." [GOC:jl]


id: GO:0044088
name: regulation of vacuole organization
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a vacuole." [GOC:jl, GOC:mah]


id: GO:0044089
name: positive regulation of cellular component biogenesis
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of cellular component biogenesis, a process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cellular component." [GOC:jl]


id: GO:0044090
name: positive regulation of vacuole organization
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a vacuole." [GOC:jl, GOC:mah]


id: GO:0044091
name: membrane biogenesis
namespace: biological_process
def:
  "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a membrane." [GOC:jl]


id: GO:0044092
name: negative regulation of molecular function
namespace: biological_process
def:
  "Any process that stops or reduces the rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding." [GO:jl]


id: GO:0044093
name: positive regulation of molecular function
namespace: biological_process
def:
  "Any process that activates or increases the rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding." [GO:jl]


id: GO:0044094
name: host cell nuclear part
namespace: cellular_component
def:
  "Any constituent part of a host cell's nucleus, a membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. The host is the larger of the organisms involved in a symbiotic interaction." [GOC:ecd]


id: GO:0044095
name: host cell nucleoplasm
namespace: cellular_component
def:
  "That part of a host cell's nuclear content other than the chromosomes or the nucleolus. The host is the larger of the organisms involved in a symbiotic interaction." [GOC:ecd]


id: GO:0044096
name: type IV pilus
namespace: cellular_component
def:
  "A short filamentous structure on the surface of a bacterial cell distinguished from other pili by post-translational N-methylation of the pilin monomers." [GOC:pamgo_curators]


id: GO:0044097
name: secretion by the type IV secretion system
namespace: biological_process
def:
  "The controlled release of proteins or DNA by a cell, via the type IV secretion system." [GOC:pamgo_curators]


id: GO:0044099
name: polar tube
namespace: cellular_component
def:
  "A highly specialized structure unique to microsporidia that is required for host cell invasion. In the spore, the polar tube is connected at the anterior end, and then coils around the sporoplasm. Upon appropriate environmental stimulation, the polar tube rapidly discharges out of the spore, pierces a cell membrane and serves as a conduit for sporoplasm passage into the new host cell." [GOC:mf, PMID:12076771, PMID:9723921]


id: GO:0044100
name: sporoplasm
namespace: cellular_component
def:
  "The complex infective apparatus corresponding to the central mass of cytoplasm within a spore that is injected into a host cell by various parasitic microorganisms." [GOC:mf, PMID:12076771, PMID:16004371, PMID:9723921]


id: GO:0044102
name: purine deoxyribosyltransferase activity
namespace: molecular_function
def:
  "Catalysis of deoxyribose exchange between purine deoxyribonucleoside as a donor and purine base as an acceptor." [GOC:jl, IMG:03313, PMID:11836245]


id: GO:0044103
name: L-arabinose 1-dehydrogenase (NADP+) activity
namespace: molecular_function
def:
  "Catalysis of the reaction: L-arabinose + NADP+ = L-arabinono-1,4-lactone + NADPH + H+." [GOC:jl, IMG:03333]


id: GO:0044104
name: 2,5-dioxovalerate dehydrogenase (NAD+) activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 2,5-dioxopentanoate + NAD+ + H2O = 2-oxoglutarate + NADH + H+." [IMG:03338, PMID:16835232, PMID:17202142]


id: GO:0044106
name: cellular amine metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving any organic compound that is weakly basic in character and contains an amino or a substituted amino group, as carried out by individual cells. Amines are called primary, secondary, or tertiary according to whether one, two, or three carbon atoms are attached to the nitrogen atom." [GOC:jl]


id: GO:0044107
name: cellular alcohol metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving alcohols, any of a class of compounds containing one or more hydroxyl groups attached to a saturated carbon atom, as carried out by individual cells." [GOC:jl]


id: GO:0044108
name: cellular alcohol biosynthetic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of alcohols, any of a class of compounds containing one or more hydroxyl groups attached to a saturated carbon atom, carried out at the level of an individual cell." [GOC:jl]


id: GO:0044109
name: cellular alcohol catabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the breakdown of alcohols, any of a class of compounds containing one or more hydroxyl groups attached to a saturated carbon atom, occurring at the level of the individual cell." [GOC:jl]


id: GO:0044110
name: growth involved in symbiotic interaction
namespace: biological_process
def:
  "The increase in size or mass of an organism occurring when the organism is in a symbiotic interaction." [GO:jl, GOC:pamgo_curators]


id: GO:0044111
name: development involved in symbiotic interaction
namespace: biological_process
def:
  "The progression of an organism from an initial condition to a later condition, occurring when the organism is in a symbiotic interaction." [GO:jl, GOC:pamgo_curators]


id: GO:0044112
name: growth in other organism involved in symbiotic interaction
namespace: biological_process
def:
  "The increase in size or mass of an organism, occurring within the cells or tissues of a second organism, where the two organisms are in a symbiotic interaction. This may (but not necessarily) include a filamentous growth form, and also can include secretion of proteases and lipases to break down the tissue of the second organism." [GOC:cc, GOC:jl]


id: GO:0044113
name: development in other organism involved in symbiotic interaction
namespace: biological_process
def:
  "The progression of an organism from an initial condition to a later condition, occurring within the cells or tissues of a second organism, where the two organisms are in a symbiotic interaction. This may (but not necessarily) include a filamentous growth form, and also can include secretion of proteases and lipases to break down the tissue of the second organism." [GO:jl, GOC:cc]


id: GO:0044114
name: development of symbiont in host
namespace: biological_process
def:
  "The progression of an organism from an initial condition to a later condition, occurring within the cells or tissues of the host organism. This may (but not necessarily) include a filamentous growth form, and also can include secretion of proteases and lipases to break down host tissue. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:jl, GOC:pamgo_curators]


id: GO:0044115
name: development of symbiont involved in interaction with host
namespace: biological_process
def:
  "The progression of an organism from an initial condition to a later condition, occurring in, on or near the exterior of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:jl, GOC:pamgo_curators]


id: GO:0044116
name: growth of symbiont involved in interaction with host
namespace: biological_process
def:
  "The increase in size or mass of an organism, occurring in, on or near the exterior of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:jl, GOC:pamgo_curators]


id: GO:0044117
name: growth of symbiont in host
namespace: biological_process
def:
  "The increase in size or mass of an organism, occurring within the cells or tissues of the host organism. This may (but not necessarily) include a filamentous growth form, and also can include secretion of proteases and lipases to break down host tissue. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:jl, GOC:pamgo_curators]


id: GO:0044118
name: development of symbiont in host cell
namespace: biological_process
def:
  "The progression of the symbiont from an initial condition to a later condition, occurring in its host's cell. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:jl, GOC:pamgo_curators]


id: GO:0044119
name: growth of symbiont in host cell
namespace: biological_process
def:
  "The increase in size or mass of symbiont, occurring in its host's cell. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:jl, GOC:pamgo_curators]


id: GO:0044120
name: development of symbiont in host organelle
namespace: biological_process
def:
  "The progression of the symbiont from an initial condition to a later condition, occurring in its host's organelle. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:jl, GOC:pamgo_curators]


id: GO:0044121
name: growth of symbiont in host organelle
namespace: biological_process
def:
  "The increase in size or mass of a symbiont, occurring in its host's organelle. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:jl, GOC:pamgo_curators]


id: GO:0044122
name: development of symbiont in host vascular tissue
namespace: biological_process
def:
  "The progression of the symbiont from an initial condition to a later condition, occurring in its host's vascular tissue. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:jl, GOC:pamgo_curators]


id: GO:0044123
name: growth of symbiont in host vascular tissue
namespace: biological_process
def:
  "The increase in size or mass of symbiont, occurring in its host's vascular tissue. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:jl, GOC:pamgo_curators]


id: GO:0044124
name: development of symbiont in host intercellular space
namespace: biological_process
def:
  "The progression of the symbiont from an initial condition to a later condition, occurring in its host's intercellular space. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:jl, GOC:pamgo_curators]


id: GO:0044125
name: growth of symbiont in host intercellular space
namespace: biological_process
def:
  "The increase in size or mass of symbiont, occurring in its host's intercellular space. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:jl, GOC:pamgo_curators]


id: GO:0044126
name: regulation of growth of symbiont in host
namespace: biological_process
def:
  "Any process in which the symbiont regulates the increase in its size or mass within the cells or tissues of the host organism. This may (but not necessarily) include a filamentous growth form, and also can include secretion of proteases and lipases to break down. The host is defined as the larger of the organisms involved in the symbiotic interaction." [GOC:jl, GOC:pamgo_curators]


id: GO:0044127
name: regulation of development of symbiont in host
namespace: biological_process
def:
  "Any process in which the symbiont regulates its progression from an initial condition to a later condition, within the cells or tissues of the host organism. This may (but not necessarily) include a filamentous growth form, and also can include secretion of proteases and lipases to break down. The host is defined as the larger of the organisms involved in the symbiotic interaction." [GOC:jl, GOC:pamgo_curators]


id: GO:0044128
name: positive regulation of growth of symbiont in host
namespace: biological_process
def:
  "Any process in which the symbiont activates, maintains or increases its size or mass within the cells or tissues of the host organism. The host is defined as the larger of the organisms involved in the symbiotic interaction." [GOC:jl, GOC:pamgo_curators]


id: GO:0044129
name: positive regulation of development of symbiont in host
namespace: biological_process
def:
  "Any process in which the symbiont activates or maintains its progression from an initial condition to a later condition, within the cells or tissues of the host organism. The host is defined as the larger of the organisms involved in the symbiotic interaction." [GOC:jl, GOC:pamgo_curators]


id: GO:0044130
name: negative regulation of growth of symbiont in host
namespace: biological_process
def:
  "Any process in which the symbiont stops, prevents or reduces its increase in size or mass within the cells or tissues of the host organism. The host is defined as the larger of the organisms involved in the symbiotic interaction." [GOC:jl, GOC:pamgo_curators]


id: GO:0044131
name: negative regulation of development of symbiont in host
namespace: biological_process
def:
  "Any process in which the symbiont stops, prevents or reduces its progression from an initial condition to a later condition, within the cells or tissues of the host organism. The host is defined as the larger of the organisms involved in the symbiotic interaction." [GOC:jl, GOC:pamgo_curators]


id: GO:0044132
name: development of symbiont on or near host
namespace: biological_process
def:
  "The progression of a symbiont from an initial condition to a later condition, within the cells or tissues of its host organism." [GOC:jl, GOC:pamgo_curators]


id: GO:0044133
name: growth of symbiont on or near host
namespace: biological_process
def:
  "The increase in size or mass of a symbiont within the cells or tissues of its host organism." [GOC:jl, GOC:pamgo_curators]


id: GO:0044134
name: development of symbiont on or near host phyllosphere
namespace: biological_process
def:
  "The progression of the symbiont from an initial condition to a later condition, occurring on or near its host phyllosphere. The host phyllosphere is defined as total above-ground surfaces of a plant as a habitat for symbiont. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:jl, GOC:pamgo_curators]


id: GO:0044135
name: growth of symbiont on or near host phyllosphere
namespace: biological_process
def:
  "The increase in size or mass of symbiont occurring on or near its host phyllosphere. The host phyllosphere is defined as total above-ground surfaces of a plant as a habitat for symbiont. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:jl, GOC:pamgo_curators]


id: GO:0044136
name: development of symbiont on or near host rhizosphere
namespace: biological_process
def:
  "The progression of the symbiont from an initial condition to a later condition, occurring on or near its host rhizosphere. The host rhizosphere is defined as total below-ground surfaces of a plant as a habitat for its symbiont. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:jl, GOC:pamgo_curators]


id: GO:0044137
name: growth of symbiont on or near host rhizosphere
namespace: biological_process
def:
  "The increase in size or mass of symbiont occurring on or near its host rhizosphere. The host rhizosphere is defined as total below-ground surfaces of a plant as a habitat for its symbiont. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:jl, GOC:pamgo_curators]


id: GO:0044138
name: modulation of development of symbiont on or near host
namespace: biological_process
def:
  "Any process in which the symbiont regulates its progression from an initial condition to a later condition, on or near the cells or tissues of the host organism." [GOC:jl, GOC:pamgo_curators]


id: GO:0044139
name: modulation of growth of symbiont on or near host
namespace: biological_process
def:
  "Any process in which the symbiont regulates the increase in its size or mass on or near the cells or tissues of the host organism." [GOC:jl, GOC:pamgo_curators]


id: GO:0044140
name: negative regulation of growth of symbiont on or near host surface
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of the increase in the symbiont's size or mass on or near the cells or tissues of the host organism." [GOC:jl, GOC:pamgo_curators]


id: GO:0044141
name: negative regulation of development of symbiont on or near host surface
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of the symbiont's progression from an initial condition to a later condition, on or near the cells or tissues of the host organism." [GOC:jl, GOC:pamgo_curators]


id: GO:0044142
name: positive regulation of growth of symbiont on or near host surface
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of the symbiont's increase in size or mass on or near the cells or tissues of the host organism." [GOC:jl, GOC:pamgo_curators]


id: GO:0044143
name: positive regulation of development of symbiont on or near host surface
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of the symbiont's progression from an initial condition to a later condition, on or near the cells or tissues of the host organism." [GOC:jl, GOC:pamgo_curators]


id: GO:0044144
name: modulation of growth of symbiont involved in interaction with host
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of the increase in size or mass of an organism occurring in, on or near the exterior of its host organism." [GOC:jl, GOC:pamgo_curators]


id: GO:0044145
name: modulation of development of symbiont involved in interaction with host
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of the progression of an organism from an initial condition to a later condition, occurring in, on or near the exterior of its host organism." [GOC:jl, GOC:pamgo_curators]


id: GO:0044146
name: negative regulation of growth of symbiont involved in interaction with host
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of the increase in size or mass of an organism occurring in, on or near the exterior of its host organism." [GOC:jl, GOC:pamgo_curators]


id: GO:0044147
name: negative regulation of development of symbiont involved in interaction with host
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of the progression of an organism from an initial condition to a later condition, occurring in, on or near the exterior of its host organism." [GOC:jl, GOC:pamgo_curators]


id: GO:0044148
name: positive regulation of growth of symbiont involved in interaction with host
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of the increase in size or mass of an organism occurring in, on or near the exterior of its host organism." [GOC:jl, GOC:pamgo_curators]


id: GO:0044149
name: positive regulation of development of symbiont involved in interaction with host
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of the progression of an organism from an initial condition to a later condition, occurring in, on or near the exterior of its host organism." [GOC:jl, GOC:pamgo_curators]


id: GO:0044150
name: development of organism on or near symbiont surface
namespace: biological_process
def:
  "The progression of an organism from an initial condition to a later condition, occurring on or near the exterior of its symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:cc, GOC:jl]


id: GO:0044151
name: growth of organism on or near symbiont surface
namespace: biological_process
def:
  "The increase in size or mass of an organism occurring on or near the exterior of its symbiont organism. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:cc, GOC:jl]


id: GO:0044152
name: development on or near surface of other organism involved in symbiotic interaction
namespace: biological_process
def:
  "The progression of an organism from an initial condition to a later condition, occurring on or near the exterior of a second organism, where the two organisms are in a symbiotic interaction." [GOC:cc, GOC:jl]


id: GO:0044153
name: growth on or near surface of other organism involved in symbiotic interaction
namespace: biological_process
def:
  "The increase in size or mass of an organism occurring on or near the exterior of a second organism, where the two organisms are in a symbiotic interaction." [GOC:cc, GOC:jl]


id: GO:0044154
name: histone H3-K14 acetylation
namespace: biological_process
def:
  "The modification of histone H3 by the addition of an acetyl group to a lysine residue at position 14 of the histone." [GOC:jl, GOC:lb, PMID:17194708]


id: GO:0044155
name: host caveola
namespace: cellular_component
def:
  "A small pit, depression, or invagination, such as any of the minute pits or incuppings of the host cell membrane formed during pinocytosis, that communicates with the outside of a host cell and extends inward, indenting the host cytoplasm and the host cell membrane. Such caveolae may be pinched off to form free vesicles within the host cytoplasm. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:rph]


id: GO:0044156
name: host cell junction
namespace: cellular_component
def:
  "A plasma membrane part that forms a specialized region of connection between two host cells or between a host cell and the host extracellular matrix. At a host cell junction, anchoring proteins extend through the host plasma membrane to link cytoskeletal proteins in one cell to cytoskeletal proteins in neighboring cells or to proteins in the extracellular matrix." [GOC:rph]


id: GO:0044158
name: host cell wall
namespace: cellular_component
def:
  "The rigid or semi-rigid envelope lying outside the host cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan." [GOC:rph]


id: GO:0044159
name: host thylakoid
namespace: cellular_component
def:
  "A membranous cellular structure within the host cell that bears the photosynthetic pigments in plants, algae, and cyanobacteria. In cyanobacteria thylakoids are of various shapes and are attached to, or continuous with, the host plasma membrane. In eukaryotic host cells they are flattened, membrane-bounded disk-like structures located in the chloroplasts; in the chloroplasts of higher plants the thylakoids form dense stacks called grana. Isolated thylakoid preparations can carry out photosynthetic electron transport and the associated phosphorylation." [GOC:rph]


id: GO:0044163
name: host cytoskeleton
namespace: cellular_component
def:
  "Any of the various filamentous elements that form the internal framework of host cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the host cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the host cell. The various elements of the host cytoskeleton not only serve in the maintenance of host cellular shape but also have roles in other host cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:rph]


id: GO:0044164
name: host cell cytosol
namespace: cellular_component
def:
  "The part of the host cell cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:jl]


id: GO:0044165
name: host cell endoplasmic reticulum
namespace: cellular_component
def:
  "The irregular network of unit membranes, visible only by electron microscopy, that occurs in the host cell cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The host ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [GOC:jl]


id: GO:0044168
name: host cell rough endoplasmic reticulum
namespace: cellular_component
def:
  "The irregular network of unit membranes, visible only by electron microscopy, that occurs in the host cell cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The host rough ER has ribosomes adhering to the outer surface." [GOC:jl]


id: GO:0044170
name: host cell smooth endoplasmic reticulum
namespace: cellular_component
def:
  "The irregular network of unit membranes, visible only by electron microscopy, that occurs in the host cell cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The host smooth ER has no ribosomes adhering to the outer surface." [GOC:jl]


id: GO:0044172
name: host cell endoplasmic reticulum-Golgi intermediate compartment
namespace: cellular_component
def:
  "A complex system of membrane-bounded compartments located between host cell endoplasmic reticulum (ER) and the host Golgi complex, with a distinctive membrane protein composition; involved in ER-to-Golgi transport." [GOC:jl, GOC:pr]


id: GO:0044173
name: host cell endoplasmic reticulum-Golgi intermediate compartment membrane
namespace: cellular_component
def:
  "The lipid bilayer surrounding any of the compartments of the host cell ER-Golgi intermediate compartment system." [GOC:jl]


id: GO:0044174
name: host cell endosome
namespace: cellular_component
def:
  "A membrane-bounded organelle that carries materials newly ingested by endocytosis. It passes many of the materials to host cell lysosomes for degradation." [GOC:jl]


id: GO:0044176
name: host cell filopodium
namespace: cellular_component
def:
  "Thin, stiff protrusion extended by the leading edge of a motile host cell such as a crawling fibroblast or amoeba, or an axonal growth cone; usually approximately 0.1 um wide, 5-10 um long, can be up to 50 um long in axon growth cones; contains a loose bundle of about 20 actin filaments oriented with their plus ends pointing outward." [GOC:jl]


id: GO:0044177
name: host cell Golgi apparatus
namespace: cellular_component
def:
  "A compound membranous cytoplasmic organelle of eukaryotic host cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack." [GOC:jl]


id: GO:0044179
name: hemolysis in other organism
namespace: biological_process
def:
  "The cytolytic destruction of red blood cells, with the release of intracellular hemoglobin, in one organism by another." [GOC:jl]


id: GO:0044180
name: filamentous growth of a unicellular organism
namespace: biological_process
def:
  "The process in which a unicellular organism grows in a threadlike, filamentous shape." [GOC:mtg_cambridge_2009]


id: GO:0044181
name: filamentous growth of a multicellular organism
namespace: biological_process
def:
  "The process in which a multicellular organism grows in a threadlike, filamentous shape." [GOC:mtg_cambridge_2009]


id: GO:0044182
name: filamentous growth of a population of unicellular organisms
namespace: biological_process
def:
  "The process in which a group of unicellular organisms grow in a threadlike, filamentous shape." [GOC:mtg_cambridge_2009]


id: GO:0044183
name: protein binding involved in protein folding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules) that contributes to the process of protein folding." [GOC:mtg_cambridge_2009]


id: GO:0044184
name: host cell late endosome
namespace: cellular_component
def:
  "A prelysosomal endocytic organelle differentiated from host early endosomes by lower lumenal pH and different protein composition. Host late endosomes are more spherical than early endosomes and are mostly juxtanuclear, being concentrated near the microtubule organizing center." [GOC:jl]


id: GO:0044186
name: host cell lipid particle
namespace: cellular_component
def:
  "Any particle of coalesced lipids in the cytoplasm of a host cell. May include associated proteins." [GOC:jl]


id: GO:0044187
name: host cell lysosome
namespace: cellular_component
def:
  "A small lytic vacuole that has cell cycle-independent morphology and is found in most host animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and host cell lysosomes have a great variety of morphologies and functions." [GOC:jl]


id: GO:0044188
name: host cell lysosomal membrane
namespace: cellular_component
def:
  "The lipid bilayer surrounding the host cell lysosome and separating its contents from the host cell cytoplasm." [GOC:jl]


id: GO:0044189
name: obsolete host cell microsome
namespace: cellular_component
def:
  "OBSOLETE: Any of the small, heterogeneous, artifactual, vesicular particles, 50-150 nm in diameter, that are formed when some eukaryotic host cells are homogenized and that sediment on centrifugation at 100000 g." [GOC:jl]


id: GO:0044190
name: host cell mitochondrial envelope
namespace: cellular_component
def:
  "The double lipid bilayer enclosing the host cell mitochondrion and separating its contents from the host cell cytoplasm; includes the intermembrane space." [GOC:jl]


id: GO:0044191
name: host cell mitochondrial membrane
namespace: cellular_component
def:
  "Either of the lipid bilayers that surround the host cell mitochondrion and form the host cell mitochondrial envelope." [GOC:jl]


id: GO:0044192
name: host cell mitochondrial inner membrane
namespace: cellular_component
def:
  "The inner, i.e. lumen-facing, lipid bilayer of the host cell mitochondrial envelope. It is highly folded to form cristae." [GOC:jl]


id: GO:0044194
name: cytolytic granule
namespace: cellular_component
def:
  "A specialized secretory lysosome that is present in cells with cytolytic capability such as cytotoxic T lymphocytes and natural killer cells. Cytolytic granules mediate the storage and regulated excretion of lytic molecules for killing of target cells." [GOC:jl, PMID:11052265, PMID:12766758]


id: GO:0044195
name: nucleoplasmic reticulum
namespace: cellular_component
def:
  "Long, dynamic tubular channels, formed by invagination of the nuclear envelope, that extend deep into the nucleoplasm. The channels have an underlying lamina and are implicated in functioning in signaling and transport." [GOC:jl, PMID:17959832, PMID:9024685]


id: GO:0044196
name: host cell nucleolus
namespace: cellular_component
def:
  "A small, dense body one or more of which are present in the nucleus of eukaryotic host cells." [GOC:jl]


id: GO:0044197
name: Rel homology domain binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with a Rel Homology Domain (RHD) of a protein. The RHD is found in a family of eukaryotic transcription factors, which includes NF-kappaB, Dorsal, Relish and NFAT." [InterPro:IPR011539, Wikipedia:Rel_homology_domain]


id: GO:0044198
name: zf-TRAF domain binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with a TRAF-type zinc finger domain of a protein." [InterPro:IPR001293]


id: GO:0044199
name: host cell nuclear envelope
namespace: cellular_component
def:
  "The double lipid bilayer enclosing the host nucleus and separating its contents from the rest of the host cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space)." [GOC:jl]


id: GO:0044200
name: host cell nuclear membrane
namespace: cellular_component
def:
  "Either of the lipid bilayers that surround the host nucleus and form the nuclear envelope; excludes the intermembrane space." [GOC:jl]


id: GO:0044202
name: host cell nuclear outer membrane
namespace: cellular_component
def:
  "The outer, i.e. cytoplasm-facing, lipid bilayer of the host nuclear envelope; continuous with the endoplasmic reticulum of the host cell and sometimes studded with ribosomes." [GOC:jl]


id: GO:0044203
name: host cell nuclear lamina
namespace: cellular_component
def:
  "The fibrous, electron-dense layer lying on the nucleoplasmic side of the inner membrane of a host cell nucleus, composed of lamin filaments." [GOC:jl]


id: GO:0044205
name: 'de novo' UMP biosynthetic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of UMP, uridine monophosphate, starting with the synthesis of (S)-dihydroorotate from bicarbonate; UMP biosynthesis may either occur via reduction by quinone, NAD(+) or oxygen." [GOC:ecd, GOC:jl]


id: GO:0044206
name: UMP salvage
namespace: biological_process
def:
  "Any process which produces UMP, uridine monophosphate, from derivatives of it (e.g. cytidine, uridine, cytosine) without de novo synthesis." [GOC:ecd, PMID:15096496]


id: GO:0044207
name: translation initiation ternary complex
namespace: cellular_component
def:
  "A ribonucleoprotein complex that contains aminoacylated initiator methionine tRNA, GTP, and initiation factor 2 (either eIF2 in eukaryotes, or IF2 in prokaryotes). In prokaryotes, fMet-tRNA (initiator) is used rather than Met-tRNA (initiator)." [GOC:jl]


id: GO:0044208
name: 'de novo' AMP biosynthetic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of adenosine monophosphate (AMP) from inosine 5'-monophosphate (IMP)." [GOC:ecd, PMID:10888601]


id: GO:0044209
name: AMP salvage
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of adenosine monophosphate (AMP) from derivatives of it (either adenine, ADP or adenosine 3',5'-bisphosphate) without de novo synthesis." [GOC:ecd, GOC:jl, PMID:8917457, PMID:9864350]


id: GO:0044210
name: 'de novo' CTP biosynthetic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of cytidine 5'-triphosphate (CTP) from simpler components." [GOC:ecd, GOC:jl, PMID:11912132, PMID:18439916]


id: GO:0044211
name: CTP salvage
namespace: biological_process
def:
  "Any process which produces cytidine 5'-triphosphate (CTP) from derivatives of it, without de novo synthesis." [GOC:ecd, GOC:jl, PMID:10501935]


id: GO:0044212
name: transcription regulatory region DNA binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with a DNA region that regulates the transcription of a region of DNA, which may be a gene, cistron, or operon. Binding may occur as a sequence specific interaction or as an interaction observed only once a factor has been recruited to the DNA by other factors." [GOC:jl, GOC:txnOH, SO:0005836]


id: GO:0044213
name: intronic transcription regulatory region DNA binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with an intronic DNA region that regulates the transcription of the transcript it is contained within." [GOC:ecd, GOC:txnOH]


id: GO:0044214
name: spanning component of plasma membrane
namespace: cellular_component
def:
  "The component of the plasma membrane consisting of gene products and protein complexes that have some part that spans both leaflets of the membrane." [GOC:ecd]


id: GO:0044217
name: other organism part
namespace: cellular_component
def:
  "Any constituent part of a secondary organism with which the first organism is interacting." [GOC:jl]


id: GO:0044219
name: host cell plasmodesma
namespace: cellular_component
def:
  "A fine cytoplasmic channel, found in all higher plants, that connects the cytoplasm of one host cell to that of an adjacent host cell." [GOC:rph]


id: GO:0044221
name: host cell synapse
namespace: cellular_component
def:
  "The junction between a nerve fiber of one host neuron and another host neuron or muscle fiber or glial cell; the site of interneuronal communication." [GOC:rph]


id: GO:0044222
name: anammoxosome
namespace: cellular_component
def:
  "An intracytoplasmic membrane-bounded compartment in anaerobic ammonium oxidation (anammox) bacteria, is the site of anammox catabolism." [GOC:dh, PMID:17993524, PMID:19682260]


id: GO:0044223
name: pirellulosome
namespace: cellular_component
def:
  "A cytoplasmic structure found in bacterial phyla Planctomycetes and Verrucomicrobia containing a condensed nucleoid and ribosomes and surrounded by an intracytoplasmic membrane. It is surrounded by ribosome-free cytoplasm, in a compartment called the paryphoplasm." [GOC:dh, PMID:19133117]


id: GO:0044224
name: juxtaparanode region of axon
namespace: cellular_component
def:
  "A region of an axon near a node of Ranvier that is between the paranode and internode regions." [GOC:BHF, GOC:jl, PMID:10624965, PMID:14682359]


id: GO:0044225
name: apical pole of neuron
namespace: cellular_component
def:
  "Portion of a neuron cell soma closest to the point where the apical dendrite emerges." [NIF_Subcellular:sao1186862860]


id: GO:0044226
name: basal pole of neuron
namespace: cellular_component
def:
  "Portion of a neuron cell soma closest to the point where the basilar dendrite emerges." [NIF_Subcellular:sao1186862860]


id: GO:0044227
name: methane-oxidizing organelle
namespace: cellular_component
def:
  "A cytoplasmic, membrane-bounded compartment found within Methanotrophic bacteria that contains enzymes and electron transfer proteins for methane catabolism. This structure is analogous to the thylakoid of Cyanobacteria and the anammoxosome of anaerobic ammonium oxidation organisms." [GOC:dh]


id: GO:0044229
name: host cell periplasmic space
namespace: cellular_component
def:
  "The region between the inner (cytoplasmic) and outer host membrane (Gram-negative Bacteria) or inner host membrane and host cell wall (Fungi)." [GOC:rph]


id: GO:0044230
name: host cell envelope
namespace: cellular_component
def:
  "An envelope that surrounds a bacterial host cell and includes the host cytoplasmic membrane and everything external, encompassing the host periplasmic space, host cell wall, and host outer membrane if present." [GOC:rph]


id: GO:0044231
name: host cell presynaptic membrane
namespace: cellular_component
def:
  "A specialized area of membrane of the host axon terminal that faces the plasma membrane of the host neuron or muscle fiber with which the axon terminal establishes a synaptic junction; many host synaptic junctions exhibit structural presynaptic characteristics, such as conical, electron-dense internal protrusions, that distinguish it from the remainder of the axon plasma membrane." [GOC:rph]


id: GO:0044232
name: organelle membrane contact site
namespace: cellular_component
def:
  "A zone of apposition between the membranes of two organelles, structured by bridging complexes. Membrane contact sites (MCSs) are specialized for communication, including the efficient traffic of small molecules such as Ca2+ ions and lipids, as well as enzyme-substrate interactions." [GOC:jl, PMID:16806880]


id: GO:0044233
name: ER-mitochondrion membrane contact site
namespace: cellular_component
def:
  "A zone of apposition between endoplasmic-reticulum and mitochondrial membranes, structured by bridging complexes. These contact sites are thought to facilitate inter-organelle calcium and phospholipid exchange." [GOC:jl, PMID:19556461]


id: GO:0044236
name: multicellular organism metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways in a single multicellular organism that occur at the tissue, organ, or organismal level. These processes, unlike cellular metabolism, can include transport of substances between cells when that transport is required." [GOC:go_curators]


id: GO:0044237
name: cellular metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways by which individual cells transform chemical substances." [GOC:go_curators]


id: GO:0044238
name: primary metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving those compounds which are formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism." [GOC:go_curators, http://www.metacyc.org]


id: GO:0044239
name: salivary polysaccharide catabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the breakdown of polysaccharides by salivary amylase. Salivary amylase is released by salivary glands, usually in the mouth." [GOC:jl, http://www.emc.maricopa.edu/]


id: GO:0044240
name: multicellular organism lipid catabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the breakdown of lipids, occurring at the tissue, organ, or organismal level of a multicellular organism." [GOC:jl]


id: GO:0044241
name: lipid digestion
namespace: biological_process
def:
  "The whole of the physical, chemical, and biochemical processes carried out by living organisms to break down ingested lipids into components that may be easily absorbed and directed into metabolism." [GOC:go_curators]


id: GO:0044242
name: cellular lipid catabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the breakdown of lipids, as carried out by individual cells." [GOC:jl]


id: GO:0044243
name: multicellular organism catabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the breakdown of substances in multicellular organisms that occur at the tissue, organ, or organismal level. These processes, unlike cellular metabolism, can include transport of substances between cells when that transport is required." [GOC:go_curators]


id: GO:0044244
name: multicellular organismal polysaccharide catabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the breakdown of polysaccharides, occurring at the tissue, organ, or organismal level of a multicellular organism." [GOC:jl]


id: GO:0044245
name: polysaccharide digestion
namespace: biological_process
def:
  "The whole of the physical, chemical, and biochemical processes carried out by living organisms to break down ingested polysaccharides into components that may be easily absorbed and directed into metabolism." [GOC:go_curators]


id: GO:0044246
name: regulation of multicellular organismal metabolic process
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of chemical reactions and pathways in multicellular organisms that occur at the tissue, organ, or organismal level." [GOC:go_curators, GOC:tb]


id: GO:0044247
name: cellular polysaccharide catabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the breakdown of polysaccharides, polymers of many (typically more than 10) monosaccharide residues linked glycosidically, as carried out by individual cells." [CHEBI:18154, GOC:jl]


id: GO:0044248
name: cellular catabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the breakdown of substances, carried out by individual cells." [GOC:jl]


id: GO:0044249
name: cellular biosynthetic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of substances, carried out by individual cells." [GOC:jl]


id: GO:0044250
name: negative regulation of metabolic activity involved in hibernation
namespace: biological_process
def:
  "The slowing of metabolic processes to very low levels in order to conserve energy as a part of hibernation." [GOC:jl, Wikipedia:Hibernation]


id: GO:0044251
name: protein catabolic process by pepsin
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the breakdown of a protein by pepsin in the stomach. Pepsin is generated from its precursor pepsinogen, which is activated by hydrolchloric acid (gastric acid)." [GOC:jl, http://www.emc.maricopa.edu/]


id: GO:0044252
name: negative regulation of multicellular organismal metabolic process
namespace: biological_process
def:
  "Any process that stops, prevents or reduces frequency, rate or extent of chemical reactions and pathways in multicellular organisms that occur at the tissue, organ, or organismal level." [GOC:jl]


id: GO:0044253
name: positive regulation of multicellular organismal metabolic process
namespace: biological_process
def:
  "Any process that activates or increases frequency, rate or extent of chemical reactions and pathways in multicellular organisms that occur at the tissue, organ, or organismal level." [GOC:jl]


id: GO:0044254
name: multicellular organismal protein catabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the breakdown of a protein in a multicellular organism, occurring at the tissue, organ, or organismal level." [GOC:jl]


id: GO:0044255
name: cellular lipid metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving lipids, as carried out by individual cells." [GOC:jl]


id: GO:0044256
name: protein digestion
namespace: biological_process
def:
  "The whole of the physical, chemical, and biochemical processes carried out by living organisms to break down ingested proteins into components that may be easily absorbed and directed into metabolism." [GOC:go_curators]


id: GO:0044257
name: cellular protein catabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the breakdown of a protein by individual cells." [GOC:jl]


id: GO:0044258
name: intestinal lipid catabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the breakdown into fatty acids and monoglycerides of lipids in the small intestine. Lipids are broken down by lipases released by the pancreas." [GOC:jl, http://www.emc.maricopa.edu/]


id: GO:0044259
name: multicellular organismal macromolecule metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving macromolecules, large molecules including proteins, nucleic acids and carbohydrates, in multicellular organisms occurring at the tissue, organ, or organismal level." [GOC:jl]


id: GO:0044260
name: cellular macromolecule metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass, as carried out by individual cells." [CHEBI:33694, GOC:mah]


id: GO:0044261
name: multicellular organism carbohydrate metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, in a single multicellular organism, occurring at the tissue, organ, or organismal level." [GOC:jl]


id: GO:0044262
name: cellular carbohydrate metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, as carried out by individual cells." [GOC:jl]


id: GO:0044263
name: multicellular organismal polysaccharide metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving polysaccharides, polymers of more than 10 monosaccharide residues joined by glycosidic linkages, in multicellular organisms that occur at the tissue, organ, or organismal level." [GOC:jl]


id: GO:0044264
name: cellular polysaccharide metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving polysaccharides, polymers of more than 10 monosaccharide residues joined by glycosidic linkages, as carried out by individual cells." [GOC:jl]


id: GO:0044265
name: cellular macromolecule catabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the breakdown of a macromolecule, any large molecule including proteins, nucleic acids and carbohydrates, as carried out by individual cells." [CHEBI:33694, GOC:jl]


id: GO:0044266
name: multicellular organismal macromolecule catabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the breakdown of a macromolecule, any large molecule including proteins, nucleic acids and carbohydrates, in multicellular organisms occurring at the tissue, organ, or organismal level." [GOC:jl]


id: GO:0044267
name: cellular protein metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving a specific protein, rather than of proteins in general, occurring at the level of an individual cell. Includes cellular protein modification." [GOC:jl]


id: GO:0044268
name: multicellular organismal protein metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving a specific protein, rather than of proteins in general, in multicellular organisms occurring at the tissue, organ, or organismal level." [GOC:jl]


id: GO:0044269
name: glycerol ether catabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the breakdown of glycerol ethers, any anhydride formed between two organic hydroxy compounds, one of which is glycerol." [GOC:jl]


id: GO:0044270
name: cellular nitrogen compound catabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the breakdown of organic and inorganic nitrogenous compounds." [GOC:jl, ISBN:0198506732]


id: GO:0044271
name: cellular nitrogen compound biosynthetic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of organic and inorganic nitrogenous compounds." [GOC:jl, ISBN:0198506732]


id: GO:0044272
name: sulfur compound biosynthetic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of compounds that contain sulfur, such as the amino acids methionine and cysteine or the tripeptide glutathione." [GOC:jl]


id: GO:0044273
name: sulfur compound catabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the breakdown of compounds that contain sulfur, such as the amino acids methionine and cysteine or the tripeptide glutathione." [GOC:jl]


id: GO:0044274
name: multicellular organism biosynthetic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of substances in multicellular organisms, occurring at the tissue, organ, or organismal level." [GOC:jl]


id: GO:0044275
name: cellular carbohydrate catabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the breakdown of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, as carried out by individual cells." [GOC:jl]


id: GO:0044276
name: multicellular organism carbohydrate catabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the breakdown of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, in a single multicellular organism occurring at the tissue, organ, or organismal level." [GOC:jl]


id: GO:0044278
name: cell wall disruption in other organism
namespace: biological_process
def:
  "A process carried out by an organism that results in the breakdown of the cell wall of a second organism." [GOC:jl]


id: GO:0044280
name: subplasmalemmal coating
namespace: cellular_component
def:
  "Electron dense material observed coating the cytoplasmic face of the plasma membrane in certain regions of a neuron, e.g., the axon initial segment; the nodal membrane at the Node of Ranvier." [NIF_Subcellular:sao1938587839]


id: GO:0044281
name: small molecule metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving small molecules, any low molecular weight, monomeric, non-encoded molecule." [GOC:curators, GOC:pde, GOC:vw]


id: GO:0044282
name: small molecule catabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the breakdown of small molecules, any low molecular weight, monomeric, non-encoded molecule." [GOC:curators, GOC:vw]


id: GO:0044283
name: small molecule biosynthetic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of small molecules, any low molecular weight, monomeric, non-encoded molecule." [GOC:curators, GOC:pde, GOC:vw]


id: GO:0044284
name: mitochondrial crista junction
namespace: cellular_component
def:
  "A tubular structure of relatively uniform size that connects a mitochondrial crista to the mitochondrial inner boundary membrane." [GOC:mcc, NIF_Subcellular:sao1825845900, PMID:21944719, PMID:21987634, PMID:22009199]


id: GO:0044285
name: bridge contact site
namespace: cellular_component
def:
  "Site of contact between the inner and outer mitochondrial membrane found in neuronal mitochondria; may play a role in maintaining the structural integrity of the inner and outer boundary membranes." [NIF_Subcellular:sao1858501007]


id: GO:0044286
name: peg and socket contact
namespace: cellular_component
def:
  "A cell-cell contact zone that consists of membrane invaginations extending from either cell, which contain tight-, gap-, and adherens junctions. Peg and socket contacts form between endothelial cells and pericytes, and between lens fiber cells." [GOC:tfm, NIF_Subcellular:sao1943947957, PMID:12883993, PMID:16166562, PMID:17591898]


id: GO:0044288
name: puncta adhaerentia
namespace: cellular_component
def:
  "A small version of the zonula adherens type junction, characterized by a symmetrical adherent point between two cells." [NIF_Subcellular:sao257629430]


id: GO:0044289
name: contact site
namespace: cellular_component
def:
  "Sites of close apposition of the inner and outer mitochondrial membrane." [NIF_Subcellular:sao447856407]


id: GO:0044290
name: mitochondrial intracristal space
namespace: cellular_component
def:
  "The space bounded by the mitochondrial cristae membranes, continuous with the intermembrane space." [NIF_Subcellular:sao508958414]


id: GO:0044291
name: cell-cell contact zone
namespace: cellular_component
def:
  "Extended zone of intimate apposition between two cells containing one or more types of intercellular junctions, e.g., the intercalated disk of muscle." [NIF_Subcellular:sao1299635018]


id: GO:0044292
name: dendrite terminus
namespace: cellular_component
def:
  "A structure at the distal end of a dendrite adapted to carry out a specific function, e.g. dendriole." [GOC:jl, NIF_Subcellular:sao28175134]


id: GO:0044293
name: dendriole
namespace: cellular_component
def:
  "Small dendrites that makes up a brush structure found as the terminal specialization of a dendrite of a unipolar brush cell (UBC)." [GOC:jl, NIF_Subcellular:sao28175134, NIF_Subcellular:sao295057932, PMID:8300904]


id: GO:0044296
name: dendritic tuft
namespace: cellular_component
def:
  "The terminal specialization found in some types of dendrites which consists of numerous small terminal branches, giving the dendrite a tufted appearance." [NIF_Subcellular:sao1340260079]


id: GO:0044297
name: cell body
namespace: cellular_component
def:
  "The portion of a cell bearing surface projections such as axons, dendrites, cilia, or flagella that includes the nucleus, but excludes all cell projections." [GOC:go_curators]


id: GO:0044298
name: cell body membrane
namespace: cellular_component
def:
  "The plasma membrane of a cell that bears surface projections such as axons, dendrites, cilia, or flagella, excluding the plasma membrane on cell projections." [GOC:ecd]


id: GO:0044299
name: C-fiber
namespace: cellular_component
def:
  "The axon of a dorsal root ganglion cell that are responsive to pain and temperature. C-fibers are small in diameter (0.2-1.5 um) and unmyelinated." [NIF_Subcellular:nlx_subcell_20090210]


id: GO:0044300
name: cerebellar mossy fiber
namespace: cellular_component
def:
  "An axon arising from cerebellar projecting cells in the cochlea, vestibular nuclei, spinal cord, reticular formation, cerebellar nuclei and basilar pontine nuclei. Mossy fibers enter through all three cerebellar peduncles and send collaterals to the deep cerebellar nuclei, then branch in the white matter and terminate in the granule cell layer. Through this branching, a given mossy fiber can innervate several folia. Mossy fibers synapse on granule cells. The synaptic contacts are made at enlargements along the length of the mossy fiber called mossy fiber rosettes. The enlargements of the rosettes give the axons as \"mossy\" appearance in Golgi stained preparations." [NIF_Subcellular:nlx_subcell_20090209]


id: GO:0044301
name: climbing fiber
namespace: cellular_component
def:
  "The axon of inferior olive neuron that projects to the cerebellar cortex, largely via the inferior cerebellar peduncle. They range in diameter from 1-3 um and are myelinated until they enter the granule cell layer. They give off collaterals to the deep cerebellar nuclei. They synapse extensively with the dendrites of Purkinje cells in the molecular layer, where each fiber branches repeatedly to \"climb\" along the Purkinje cell dendritic tree. Each Purkinje cell is innervated by only a single climbing fiber." [NIF_Subcellular:nlx_subcell_20090203]


id: GO:0044302
name: dentate gyrus mossy fiber
namespace: cellular_component
def:
  "Distinctive, unmyelinated axons produced by granule cells." [NIF_Subcellular:nlx_subcell_20090601, PMID:17765709]


id: GO:0044303
name: axon collateral
namespace: cellular_component
def:
  "Any of the smaller branches of an axon that emanate from the main axon cylinder." [NIF_Subcellular:sao1470140754]


id: GO:0044304
name: main axon
namespace: cellular_component
def:
  "The main axonal trunk, as opposed to the collaterals; i.e., excluding collaterals, terminal, spines, or dendrites." [NIF_Subcellular:sao1596975044]


id: GO:0044305
name: calyx of Held
namespace: cellular_component
def:
  "The terminal specialization of a calyciferous axon which forms large synapses in the mammalian auditory central nervous system." [NIF_Subcellular:sao1684283879, PMID:11823805]


id: GO:0044308
name: axonal spine
namespace: cellular_component
def:
  "A spine that originates from the axon, usually from the initial segment." [NIF_Subcellular:sao18239917]


id: GO:0044309
name: neuron spine
namespace: cellular_component
def:
  "A small membranous protrusion, often ending in a bulbous head and attached to the neuron by a narrow stalk or neck." [ISBN:0198504888, NIF_Subcellular:sao1145756102]


id: GO:0044310
name: osmiophilic body
namespace: cellular_component
def:
  "A membrane-bounded vesicle found predominantly in Plasmodium female gametocytes, that becomes progressively more abundant as the gametocyte reaches full maturity. These vesicles lie beneath the subpellicular membrane of the gametocyte, and the release of their contents into the parasitophorous vacuole has been postulated to aid in the escape of gametocytes from the erythrocyte after ingestion by the mosquito." [GOC:jl, PMID:18086189]


id: GO:0044311
name: exoneme
namespace: cellular_component
def:
  "A dense granule-like organelle of the apical complex of merozoites, released into the parasitophorous vacuole, mediating protease-dependent rupture and parasite exit from the infected erythrocyte." [GOC:jl, PMID:18083092, PMID:18083098]


id: GO:0044312
name: crystalloid
namespace: cellular_component
def:
  "A transient, cytoplasmic organelle found in Plasmodium species that resembles a cytoplasmic inclusion body and whose function is poorly understood. Crystalloids form in ookinetes and disappear after ookinete-to-oocyst transformation." [GOC:jl, PMID:19932717]


id: GO:0044313
name: protein K6-linked deubiquitination
namespace: biological_process
def:
  "A protein deubiquitination process in which a K6-linked ubiquitin chain, i.e. a polymer of ubiquitin formed by linkages between lysine residues at position 6 of the ubiquitin monomers, is removed from a protein." [GOC:sp]


id: GO:0044314
name: protein K27-linked ubiquitination
namespace: biological_process
def:
  "A protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 27 of the ubiquitin monomers, is added to a protein." [PMID:19345326]


id: GO:0044315
name: protein secretion by the type VII secretion system
namespace: biological_process
def:
  "The process in which proteins are transferred into the extracellular milieu or directly into host cells, via the type VII protein secretion system." [PMID:17922044, PMID:19876390]


id: GO:0044316
name: cone cell pedicle
namespace: cellular_component
def:
  "A specialized axon terminus which is produced by retinal cone cells. Pedicles are large, conical, flat end-feet (8-10 micrometers diameter) of the retinal cone axon that lie more or less side by side on the same plane at the outer edge of the outer plexiform layer (OPL)." [http://webvision.med.utah.edu/photo2.html, PMID:10939333]


id: GO:0044317
name: rod spherule
namespace: cellular_component
def:
  "A specialized neuron projection which is the site of synaptic transmission produced by retinal rod cells. Rod spherules are small round enlargements of the axon (3-5 micrometers diameter) or even extensions of the cell body." [http://webvision.med.utah.edu/photo2.html]


id: GO:0044318
name: L-aspartate:fumarate oxidoreductase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: L-aspartate + fumarate = alpha-iminosuccinate + succinate." [PMID:20149100]


id: GO:0044319
name: wound healing, spreading of cells
namespace: biological_process
def:
  "The migration of a cell along or through a wound gap that contributes to the reestablishment of a continuous surface." [GOC:jl]


id: GO:0044320
name: cellular response to leptin stimulus
namespace: biological_process
def:
  "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a leptin stimulus. Leptin is a hormone manufactured primarily in the adipocytes of white adipose tissue, and the level of circulating leptin is directly proportional to the total amount of fat in the body. It plays a key role in regulating energy intake and energy expenditure, including appetite and metabolism." [GOC:yaf]


id: GO:0044321
name: response to leptin
namespace: biological_process
def:
  "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a leptin stimulus. Leptin is a hormone manufactured primarily in the adipocytes of white adipose tissue, and the level of circulating leptin is directly proportional to the total amount of fat in the body. It plays a key role in regulating energy intake and energy expenditure, including appetite and metabolism]." [GOC:yaf]


id: GO:0044322
name: endoplasmic reticulum quality control compartment
namespace: cellular_component
def:
  "A subcompartment of the endoplasmic reticulum in which proteins with improper or incorrect folding accumulate. Enzymes in this compartment direct proteins with major folding problems to translocation to the cytosol and degradation, and proteins with minor folding problems to the ER, to interact with chaperon proteins." [PMID:11408579]


id: GO:0044323
name: retinoic acid-responsive element binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with a retinoic acid-responsive element, a variable direct repeat of the sequence PuGGTCA spaced by five nucleotides (DR5) found in the promoters of retinoic acid-responsive genes, to which retinoic acid receptors bind." [GOC:jl, GOC:vw, GOC:yaf, PMID:11327309, PMID:19917671]


id: GO:0044324
name: regulation of transcription involved in anterior/posterior axis specification
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of transcription that contributes to the specification of the anterior/posterior axis." [GOC:jl]


id: GO:0044325
name: ion channel binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with one or more specific sites on an ion channel, a protein complex that spans a membrane and forms a water-filled channel across the phospholipid bilayer allowing selective ion transport down its electrochemical gradient." [GOC:BHF, GOC:jl]


id: GO:0044326
name: dendritic spine neck
namespace: cellular_component
def:
  "Part of the dendritic spine that connects the dendritic shaft to the head of the dendritic spine." [GOC:nln]


id: GO:0044327
name: dendritic spine head
namespace: cellular_component
def:
  "Distal part of the dendritic spine, that carries the post-synaptic density." [GOC:BHF, GOC:nln, GOC:rl]


id: GO:0044328
name: canonical Wnt signaling pathway involved in positive regulation of endothelial cell migration
namespace: biological_process
def:
  "The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes involved in the positive regulation of endothelial cell migration." [GOC:BHF, GOC:jl]


id: GO:0044329
name: canonical Wnt signaling pathway involved in positive regulation of cell-cell adhesion
namespace: biological_process
def:
  "The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes involved in the positive regulation of cell to cell adhesion." [GOC:BHF, GOC:jl]


id: GO:0044330
name: canonical Wnt signaling pathway involved in positive regulation of wound healing
namespace: biological_process
def:
  "The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes involved in positive regulation of wound healing." [GOC:BHF, GOC:jl]


id: GO:0044331
name: cell-cell adhesion mediated by cadherin
namespace: biological_process
def:
  "The attachment of one cell to another cell via a cadherin, transmembrane proteins having repeating extracellular calcium ion binding domains." [GOC:ha, GOC:hjd, GOC:jl, PMID:10923970]


id: GO:0044332
name: Wnt signaling pathway involved in dorsal/ventral axis specification
namespace: biological_process
def:
  "The series of molecular signals initiated by binding of Wnt protein to a frizzled family receptor on the surface of the target cell contributing to the establishment, maintenance and elaboration of the dorsal/ventral axis." [GOC:jl, GOC:yaf]


id: GO:0044333
name: Wnt signaling pathway involved in digestive tract morphogenesis
namespace: biological_process
def:
  "The series of molecular signals initiated by binding of Wnt protein to a frizzled family receptor on the surface of the target cell contributing to the generation and the organization of the digestive tract." [GOC:BHF, GOC:jl]


id: GO:0044334
namespace: biological_process
name:
  canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition

def:
  "The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes involved in the positive regulation of epithelial cell to mesenchymal cell transition." [GOC:BHF, GOC:jl]


id: GO:0044335
name: canonical Wnt signaling pathway involved in neural crest cell differentiation
namespace: biological_process
def:
  "The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes involved in neural crest cell differentiation." [GOC:BHF, GOC:jl]


id: GO:0044336
name: canonical Wnt signaling pathway involved in negative regulation of apoptotic process
namespace: biological_process
def:
  "The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes involved in the negative regulation of apoptotic process." [GOC:BHF, GOC:jl, GOC:mtg_apoptosis]


id: GO:0044337
name: canonical Wnt signaling pathway involved in positive regulation of apoptotic process
namespace: biological_process
def:
  "The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes involved in the positive regulation of apoptotic process." [GOC:BHF, GOC:jl, GOC:mtg_apoptosis]


id: GO:0044338
name: canonical Wnt signaling pathway involved in mesenchymal stem cell differentiation
namespace: biological_process
def:
  "The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes involved in mesenchymal stem cell differentiation." [GOC:BHF, GOC:jl]


id: GO:0044339
name: canonical Wnt signaling pathway involved in osteoblast differentiation
namespace: biological_process
def:
  "The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes involved in osteoblast differentiation." [GOC:BHF, GOC:jl]


id: GO:0044340
name: canonical Wnt signaling pathway involved in regulation of cell proliferation
namespace: biological_process
def:
  "The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes that contributes to modulating the rate or frequency of cell proliferation." [GOC:BHF, GOC:jl]


id: GO:0044341
name: sodium-dependent phosphate transport
namespace: biological_process
def:
  "The directed movement of phosphate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore, by a mechanism dependent upon sodium ions." [GOC:BHF, GOC:jl]


id: GO:0044342
name: type B pancreatic cell proliferation
namespace: biological_process
def:
  "The multiplication or reproduction of pancreatic B cells, resulting in the expansion of an pancreatic B cell population. Pancreatic B cell are cells of the pancreas that secrete insulin." [GOC:jl, GOC:yaf]


id: GO:0044343
name: canonical Wnt signaling pathway involved in regulation of type B pancreatic cell proliferation
namespace: biological_process
def:
  "The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes that modulates the rate or frequency of pancreatic B cell proliferation. Pancreatic B cell are cells of the pancreas that secrete insulin." [GOC:jl, GOC:yaf]


id: GO:0044344
name: cellular response to fibroblast growth factor stimulus
namespace: biological_process
def:
  "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an fibroblast growth factor stimulus." [GOC:jl, GOC:yaf]


id: GO:0044345
name: stromal-epithelial cell signaling involved in prostate gland development
namespace: biological_process
def:
  "The process of transferring information from a stromal cell to an epithelial cell where it is received and interpreted, as part of prostate gland development." [GOC:jl, GOC:yaf]


id: GO:0044346
name: fibroblast apoptotic process
namespace: biological_process
def:
  "Any apoptotic process in a fibroblast, a connective tissue cell which secretes an extracellular matrix rich in collagen and other macromolecules." [CL:0000057, GOC:jl, GOC:mtg_apoptosis, GOC:yaf]


id: GO:0044347
name: cell wall polysaccharide catabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the breakdown of cell wall polysaccharides." [GOC:mengo_curators]


id: GO:0044348
name: plant-type cell wall cellulose catabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the breakdown of cellulose, a linear beta1-4 glucan of molecular mass 50-400 kDa with the pyranose units in the -4C1 conformation, which forms part of the cell wall." [GOC:mengo_curators]


id: GO:0044349
name: DNA excision
namespace: biological_process
def:
  "The removal of a section of DNA from a larger DNA molecule by the making of dual incisions that flank the section to be excised." [GOC:jl]


id: GO:0044350
name: micropinocytosis
namespace: biological_process
def:
  "An endocytosis process that results in the uptake of liquid material by cells from their external environment by invagination of the plasma membrane to form uncoated micropinosomes, differentiated from macropinosomes by their smaller size, on average 95 nm." [PMID:14731589, PMID:14732047]


id: GO:0044351
name: macropinocytosis
namespace: biological_process
def:
  "An endocytosis process that results in the uptake of liquid material by cells from their external environment by the 'ruffling' of the cell membrane to form heterogeneously sized intracellular vesicles called macropinosomes, which can be up to 5 micrometers in size." [PMID:14732047]


id: GO:0044352
name: pinosome
namespace: cellular_component
def:
  "A membrane-bounded, uncoated intracellular vesicle formed by the process of pinocytosis." [PMID:14731589, PMID:14732047]


id: GO:0044353
name: micropinosome
namespace: cellular_component
def:
  "A membrane-bounded, uncoated intracellular vesicle formed by the process of micropinocytosis." [PMID:14731589, PMID:14732047]


id: GO:0044354
name: macropinosome
namespace: cellular_component
def:
  "A membrane-bounded, uncoated intracellular vesicle formed by the process of macropinocytosis." [PMID:14732047]


id: GO:0044356
name: clearance of foreign intracellular DNA by conversion of DNA cytidine to uridine
namespace: biological_process
def:
  "A defense process that protects an organism from invading foreign DNA. The process begins by the deamination of foreign double-stranded DNA cytidines to uridines. These atypical DNA nucleosides are then converted by a uracil DNA glycosylase to abasic lesions, and the process ends with the degradation of the foreign DNA." [GO:jl, PMID:20062055]


id: GO:0044357
name: regulation of rRNA stability
namespace: biological_process
def:
  "Any process that modulates the propensity of rRNA molecules to degradation. Includes processes that both stabilize and destabilize rRNAs." [GOC:jl]


id: GO:0044358
name: envenomation resulting in hemorrhagic damage to other organism
namespace: biological_process
def:
  "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with vascular damage and hemorrhage in the bitten organism." [PMID:10441379, PMID:20614020]


id: GO:0044359
name: modulation of molecular function in other organism
namespace: biological_process
def:
  "The process in which an organism effects a change in the function of proteins in a second organism." [GOC:jl]


id: GO:0044360
name: modulation of voltage-gated potassium channel activity in other organism
namespace: biological_process
def:
  "Any process in which an organism effects a change in the frequency, rate or extent of the activity of a voltage-gated potassium channel in another organism." [GOC:jl]


id: GO:0044361
name: negative regulation of voltage-gated potassium channel activity in other organism
namespace: biological_process
def:
  "Any process in which an organism stops, prevents or reduces the frequency, rate or extent of the activity of a voltage-gated potassium channel in another organism." [GOC:jl]


id: GO:0044362
name: negative regulation of molecular function in other organism
namespace: biological_process
def:
  "Any process in which an organism stops, prevents or reduces the frequency, rate or extent of the function of proteins in a second organism." [GOC:jl]


id: GO:0044363
name: modulation of potassium channel activity in other organism
namespace: biological_process
def:
  "Any process in which an organism effects a change in the frequency, rate or extent of the activity of a potassium channel in another organism." [GOC:jl]


id: GO:0044364
name: disruption of cells of other organism
namespace: biological_process
def:
  "A process in which an organism has a negative effect on the functioning of the second organism's cells." [GOC:jl]


id: GO:0044365
name: envenomation resulting in modulation of platelet aggregation in other organism
namespace: biological_process
def:
  "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with a resultant change to the frequency, rate or extent of platelet aggregation in the bitten organism." [GOC:fj, GOC:jl]


id: GO:0044366
name: feeding on or from other organism
namespace: biological_process
def:
  "The process of consuming the whole or part of another organism for the purposes of nutrition." [GOC:jl]


id: GO:0044367
name: feeding from tissue of other organism
namespace: biological_process
def:
  "The behaviour of consuming part of another organism for the purposes of nutrition via a particular tissue e.g. vascular tissue." [GOC:jl]


id: GO:0044368
name: feeding from vascular tissue of another organism
namespace: biological_process
def:
  "The behaviour of consuming part of another organism for the purposes of nutrition via a vascular tissue." [GOC:jl]


id: GO:0044369
name: feeding on blood of other organism
namespace: biological_process
def:
  "The behaviour of feeding on the blood of another organism via specialized mouth parts and chemical agents used to penetrate vascular structures in the skin of hosts." [GOC:jl]


id: GO:0044370
name: injection of substance into other organism during feeding on blood of other organism
namespace: biological_process
def:
  "The process of forcing a substance into the bloodstream of another organism, whilst feeding on blood of other organism. The substance may facilitate the feeding process, e.g. by preventing the blood from clotting." [GOC:jl]


id: GO:0044371
name: feeding from phloem of other organism
namespace: biological_process
def:
  "The behaviour of consuming phloem sap, usually by penetration of the phloem wall, for the purposes of nutrition." [GOC:jl]


id: GO:0044372
name: feeding from xylem of other organism
namespace: biological_process
def:
  "The behaviour of consuming xylem exudate from plant xylem tissue for the purposes of nutrition." [GOC:jl]


id: GO:0044373
name: cytokinin binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with a cytokinin, any of a class of adenine-derived compounds that can function in plants as growth regulators." [GOC:jl]


id: GO:0044374
name: sequence-specific DNA binding, bending
namespace: molecular_function
def:
  "The activity of binding selectively and non-covalently to DNA in a sequence-specific manner and distorting the original structure of DNA, typically a straight helix, into a bend, or increasing the bend if the original structure was intrinsically bent due to its sequence." [GOC:jl, GOC:vw]


id: GO:0044375
name: regulation of peroxisome size
namespace: biological_process
def:
  "Any process that modulates the volume of a peroxisome, a small, membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules." [GOC:jl]


id: GO:0044376
name: RNA polymerase II complex import to nucleus
namespace: biological_process
def:
  "The directed movement of the DNA-directed RNA polymerase II core complex from the cytoplasm into the nucleus." [GOC:dos, GOC:jl]


id: GO:0044377
name: RNA polymerase II core promoter proximal region sequence-specific DNA binding, bending
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase II and distorting the original structure of DNA, typically a straight helix, into a bend, or increasing the bend if the original structure was intrinsically bent due to its sequence." [GOC:jl]


id: GO:0044378
name: non-sequence-specific DNA binding, bending
namespace: molecular_function
def:
  "The activity of binding selectively and non-covalently to DNA in a sequence-independent manner and distorting the original structure of DNA, typically a straight helix, into a bend, or increasing the bend if the original structure was intrinsically bent due to its sequence." [GOC:jl, GOC:vw, PMID:20123079]


id: GO:0044379
name: protein localization to actin cortical patch
namespace: biological_process
def:
  "A process in which a protein is transported to, or maintained in, an actin cortical patch." [GOC:mah, PMID:21620704]


id: GO:0044380
name: protein localization to cytoskeleton
namespace: biological_process
def:
  "A process in which a protein is transported to, or maintained in, a location within the cytoskeleton." [GOC:jl]


id: GO:0044381
name: glucose import in response to insulin stimulus
namespace: biological_process
def:
  "The directed movement of the hexose monosaccharide glucose into a cell as a result of an insulin stimulus." [GOC:BHF, PMID:19079291]


id: GO:0044382
name: CLRC ubiquitin ligase complex localization to heterochromatin
namespace: biological_process
def:
  "The process by which a CLRC ubiquitin ligase complex is transported to, or maintained in, heterochromatin. CLRC ubiquitin ligase complex is an active cullin-dependent E3 ubiquitin ligase complex essential for heterochromatin assembly by RNAi and histone H3K9 methylation." [GOC:jl]


id: GO:0044383
name: host chromosome
namespace: cellular_component
def:
  "A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information, occurring within a host cell." [GOC:jl]


id: GO:0044384
name: host outer membrane
namespace: cellular_component
def:
  "The external membrane of Gram-negative bacteria or certain organelles such as mitochondria and chloroplasts; freely permeable to most ions and metabolites, occurring in a host cell." [GOC:jl]


id: GO:0044385
name: integral to membrane of host cell
namespace: cellular_component
def:
  "Penetrating at least one phospholipid bilayer of a membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. When used to describe a protein, indicates that all or part of the peptide sequence is embedded in the membrane. Occurring in a host cell." [GOC:jl]


id: GO:0044386
name: integral to host endoplasmic reticulum membrane
namespace: cellular_component
def:
  "Penetrating at least one phospholipid bilayer of an endoplasmic reticulum membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer. Occurring in a host cell." [GOC:jl]


id: GO:0044387
name: negative regulation of protein kinase activity by regulation of protein phosphorylation
namespace: biological_process
def:
  "The stopping, prevention, or reduction in frequency, rate or extent of protein kinase activity as a result of regulating the phosphorylation status of that protein kinase." [GOC:jl]


id: GO:0044388
name: small protein activating enzyme binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with a small protein activating enzyme, such as ubiquitin-activating enzyme." [GOC:jl]


id: GO:0044389
name: ubiquitin-like protein ligase binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with a ubiquitin-like protein ligase, such as ubiquitin-ligase." [GOC:jl]


id: GO:0044390
name: ubiquitin-like protein conjugating enzyme binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with a ubiquitin-like protein conjugating enzyme such as ubiquitin conjugating enzyme." [GOC:jl]


id: GO:0044391
name: ribosomal subunit
namespace: cellular_component
def:
  "Either of the two subunits of a ribosome: the ribosomal large subunit or the ribosomal small subunit." [GOC:jl]


id: GO:0044392
name: peptidyl-lysine malonylation
namespace: biological_process
def:
  "The addition of a malonyl group (CO-CH2-CO) to peptidyl-lysine to form N6-malonyl-L-lysine." [GOC:jsg, GOC:sp, PMID:21908771, PMID:22076378, RESID:AA0568]


id: GO:0044393
name: microspike
namespace: cellular_component
def:
  "A dynamic, actin-rich projection extending from the surface of a migrating animal cell." [PMID:11429692, PMID:12153987, PMID:19095735]


id: GO:0044394
name: protein malonylation
namespace: biological_process
def:
  "The modification of a protein amino acid by the addition of a malonyl (CO-CH2-CO) group." [CHEBI:25134, GOC:sp]


id: GO:0044395
name: protein targeting to vacuolar membrane
namespace: biological_process
def:
  "The process of directing proteins towards the vacuolar membrane; usually uses signals contained within the protein." [GOC:jl]


id: GO:0044396
name: actin cortical patch organization
namespace: biological_process
def:
  "A process that is carried out at the cellular level and results in the assembly, arrangement of constituent parts, or disassembly of an actin cortical patch, a discrete actin-containing structure found at the plasma membrane in cells, at sites of endocytosis." [GOC:jl]


id: GO:0044397
name: actin cortical patch internalization
namespace: biological_process
def:
  "A process of actin cortical patch localization in which the patch moves from the cell surface to the inside of the cell." [GOC:mah]


id: GO:0044398
name: envenomation resulting in induction of edema in other organism
namespace: biological_process
def:
  "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the swelling of soft tissues of the bitten organism as a result of excess water accumulation." [GOC:jl, PMID:20562011]


id: GO:0044399
name: multi-species biofilm formation
namespace: biological_process
def:
  "A process in which planktonically growing microorganisms of different species grow at a liquid-air interface or on a solid substrate under the flow of a liquid and produce extracellular polymers that facilitate matrix formation, resulting in a change in the organisms' growth rate and gene transcription." [GOC:cc, GOC:di, GOC:tb]


id: GO:0044400
name: multi-species biofilm formation on inanimate substrate
namespace: biological_process
def:
  "A process in which microorganisms of different species attach to and grow on an inanimate surface such as a rock or pipe and produce extracellular polymers that facilitate attachment and matrix formation, resulting in a change in the organisms' growth rate and gene transcription." [GOC:cc]


id: GO:0044401
name: multi-species biofilm formation in or on host organism
namespace: biological_process
def:
  "A process in which microorganisms of different species attach to and grow in or on a host species, and produce extracellular polymers that facilitate attachment and matrix formation,  resulting in a change in the microorganisms' growth rate and gene transcription.  The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:cc]


id: GO:0044402
name: competition with other organism
namespace: biological_process
def:
  "Any process in which an organism within a multispecies community gains an advantage in growth or survival over another organism of a different species in that community." [GOC:cc]


id: GO:0044403
name: symbiosis, encompassing mutualism through parasitism
namespace: biological_process
def:
  "An interaction between two organisms living together in more or less intimate association. Microscopic symbionts are often referred to as endosymbionts. The various forms of symbiosis include parasitism, in which the association is disadvantageous or destructive to one of the organisms; mutualism, in which the association is advantageous, or often necessary to one or both and not harmful to either; and commensalism, in which one member of the association benefits while the other is not affected. However, mutualism, parasitism, and commensalism are often not discrete categories of interactions and should rather be perceived as a continuum of interaction ranging from parasitism to mutualism. In fact, the direction of a symbiotic interaction can change during the lifetime of the symbionts due to developmental changes as well as changes in the biotic/abiotic environment in which the interaction occurs." [GOC:cc, http://www.free-definition.com]


id: GO:0044405
name: recognition of host
namespace: biological_process
def:
  "The set of specific processes that allow an organism to detect the presence of its host via physical or chemical signals. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:cc]


id: GO:0044406
name: adhesion of symbiont to host
namespace: biological_process
def:
  "The attachment of a symbiont to its host via adhesion molecules, general stickiness etc., either directly or indirectly. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:bf, GOC:cc, GOC:dos, GOC:jl]


id: GO:0044407
name: single-species biofilm formation in or on host organism
namespace: biological_process
def:
  "A process in which microorganisms of the same species attach to and grow in or on a host species, and produce extracellular polymers that facilitate attachment and matrix formation, resulting in a change in the microorganisms' growth rate and gene transcription. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:cc]


id: GO:0044408
name: obsolete growth or development of symbiont on or near host
namespace: biological_process
def:
  "OBSOLETE. Any process in which the symbiont regulates the increase in its size or mass, or its progression from an initial condition to a later condition, within the cells or tissues of the host organism." [GOC:cc]


id: GO:0044409
name: entry into host
namespace: biological_process
def:
  "Penetration by an organism into the body, tissues, or cells of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:cc]


id: GO:0044410
name: entry into host through natural portals
namespace: biological_process
def:
  "Penetration by an organism into its host organism via naturally occurring openings in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:cc]


id: GO:0044411
name: entry into host through host barriers
namespace: biological_process
def:
  "Penetration by an organism into its host organism via active breaching of the physical barriers of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:cc]


id: GO:0044412
name: obsolete growth or development of symbiont in host
namespace: biological_process
def:
  "OBSOLETE. The increase in size or mass of an organism, or the progression of an organism from an initial condition to a later condition, occurring within the cells or tissues of the host organism. This may (but not necessarily) include a filamentous growth form, and also can include secretion of proteases and lipases to break down host tissue. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:cc]


id: GO:0044413
name: avoidance of host defenses
namespace: biological_process
def:
  "Any process, either constitutive or induced, by which an organism evades, suppresses or tolerates the effects of its host organism's defense(s). Host defenses may be induced by the presence of the organism or may be preformed (e.g. physical barriers). The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]


id: GO:0044414
name: suppression of host defenses
namespace: biological_process
def:
  "Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of host defense(s) by active mechanisms that normally result in the shutting down of a host pathway. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:cc]


id: GO:0044415
name: evasion or tolerance of host defenses
namespace: biological_process
def:
  "Any process, either active or passive, by which an organism avoids or tolerates the effects of its host organism's defense(s). Host defenses may be induced by the presence of the organism or may be preformed (e.g. physical barriers). The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:cc]


id: GO:0044416
name: induction by symbiont of host defense response
namespace: biological_process
def:
  "The activation by an organism of the defense response of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:cc]


id: GO:0044417
name: translocation of molecules into host
namespace: biological_process
def:
  "The directed movement of a molecule(s) produced by an organism to a location inside its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:cc]


id: GO:0044418
name: translocation of DNA into host
namespace: biological_process
def:
  "The directed movement of DNA from an organism to a location inside its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:cc]


id: GO:0044420
name: extracellular matrix component
namespace: cellular_component
def:
  "Any constituent part of the extracellular matrix, the structure lying external to one or more cells, which provides structural support for cells or tissues; may be completely external to the cell (as in animals) or be part of the cell (as often seen in plants)." [GOC:jl]


id: GO:0044421
name: extracellular region part
namespace: cellular_component
def:
  "Any constituent part of the extracellular region, the space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers constituent parts of the host cell environment outside an intracellular parasite." [GOC:jl]


id: GO:0044422
name: organelle part
namespace: cellular_component
def:
  "Any constituent part of an organelle, an organized structure of distinctive morphology and function. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, but excludes the plasma membrane." [GOC:jl]


id: GO:0044423
name: virion part
namespace: cellular_component
def:
  "Any constituent part of a virion, a complete fully infectious extracellular virus particle." [GOC:jl]


id: GO:0044424
name: intracellular part
namespace: cellular_component
def:
  "Any constituent part of the living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [GOC:jl]


id: GO:0044425
name: membrane part
namespace: cellular_component
def:
  "Any constituent part of a membrane, a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins." [GOC:jl]


id: GO:0044426
name: cell wall part
namespace: cellular_component
def:
  "Any constituent part of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis." [GOC:jl]


id: GO:0044427
name: chromosomal part
namespace: cellular_component
def:
  "Any constituent part of a chromosome, a structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information." [GOC:jl]


id: GO:0044428
name: nuclear part
namespace: cellular_component
def:
  "Any constituent part of the nucleus, a membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated." [GOC:jl]


id: GO:0044429
name: mitochondrial part
namespace: cellular_component
def:
  "Any constituent part of a mitochondrion, a semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:jl]


id: GO:0044430
name: cytoskeletal part
namespace: cellular_component
def:
  "Any constituent part of the cytoskeleton, a cellular scaffolding or skeleton that maintains cell shape, enables some cell motion (using structures such as flagella and cilia), and plays important roles in both intra-cellular transport (e.g. the movement of vesicles and organelles) and cellular division. Includes constituent parts of intermediate filaments, microfilaments, microtubules, and the microtrabecular lattice." [GOC:jl]


id: GO:0044431
name: Golgi apparatus part
namespace: cellular_component
def:
  "Any constituent part of the Golgi apparatus, a compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack." [GOC:jl]


id: GO:0044432
name: endoplasmic reticulum part
namespace: cellular_component
def:
  "Any constituent part of the endoplasmic reticulum, the irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae." [GOC:jl]


id: GO:0044433
name: cytoplasmic vesicle part
namespace: cellular_component
def:
  "Any constituent part of cytoplasmic vesicle, a vesicle formed of membrane or protein, found in the cytoplasm of a cell." [GOC:jl]


id: GO:0044434
name: chloroplast part
namespace: cellular_component
def:
  "Any constituent part of a chloroplast, a chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma." [GOC:jl]


id: GO:0044435
name: plastid part
namespace: cellular_component
def:
  "Any constituent part of a plastid, a member of a family of organelles found in the cytoplasm of plants and some protists, which are membrane-bounded and contain DNA. Plant plastids develop from a common type, the proplastid." [GOC:jl]


id: GO:0044436
name: thylakoid part
namespace: cellular_component
def:
  "Any constituent part of a thylakoid, a sac-like vesicle that bears the photosynthetic pigments in photosynthetic organisms." [GOC:jl]


id: GO:0044437
name: vacuolar part
namespace: cellular_component
def:
  "Any constituent part of a vacuole, a closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material." [GOC:jl]


id: GO:0044438
name: microbody part
namespace: cellular_component
def:
  "Any constituent part of a microbody, a cytoplasmic organelle, spherical or oval in shape, that is bounded by a single membrane and contains oxidative enzymes, especially those utilizing hydrogen peroxide (H2O2)." [GOC:jl]


id: GO:0044439
name: peroxisomal part
namespace: cellular_component
def:
  "Any constituent part of a peroxisome, a small, membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules; contains some enzymes that produce and others that degrade hydrogen peroxide (H2O2)." [GOC:jl]


id: GO:0044440
name: endosomal part
namespace: cellular_component
def:
  "Any constituent part of an endosome, a membrane-bounded organelle to which materials ingested by endocytosis are delivered." [GOC:mah, PMID:19696797]


id: GO:0044441
name: ciliary part
namespace: cellular_component
def:
  "Any constituent part of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:cilia, GOC:jl]


id: GO:0044443
name: pilus part
namespace: cellular_component
def:
  "Any constituent part of a pilus, a proteinaceous hair-like appendage on the surface of bacteria ranging from 2-8 nm in diameter." [GOC:pamgo_curators]


id: GO:0044444
name: cytoplasmic part
namespace: cellular_component
def:
  "Any constituent part of the cytoplasm, all of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [GOC:jl]


id: GO:0044445
name: cytosolic part
namespace: cellular_component
def:
  "Any constituent part of cytosol, that part of the cytoplasm that does not contain membranous or particulate subcellular components." [GOC:jl]


id: GO:0044446
name: intracellular organelle part
namespace: cellular_component
def:
  "A constituent part of an intracellular organelle, an organized structure of distinctive morphology and function, occurring within the cell. Includes constituent parts of the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton but excludes the plasma membrane." [GOC:jl]


id: GO:0044447
name: axoneme part
namespace: cellular_component
def:
  "Any constituent part of an axoneme, the bundle of microtubules and associated proteins that forms the core of cilia (also called flagella) in eukaryotic cells and is responsible for their movements." [GOC:cilia, GOC:jl]


id: GO:0044448
name: cell cortex part
namespace: cellular_component
def:
  "Any constituent part of the cell cortex, the region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins." [GOC:jl]


id: GO:0044449
name: contractile fiber part
namespace: cellular_component
def:
  "Any constituent part of a contractile fiber, a fiber composed of actin, myosin, and associated proteins, found in cells of smooth or striated muscle." [GOC:jl]


id: GO:0044450
name: microtubule organizing center part
namespace: cellular_component
def:
  "Any constituent part of a microtubule organizing center, a region in a eukaryotic cell, such as a centrosome or basal body, from which microtubules grow." [GOC:jl]


id: GO:0044451
name: nucleoplasm part
namespace: cellular_component
def:
  "Any constituent part of the nucleoplasm, that part of the nuclear content other than the chromosomes or the nucleolus." [GOC:jl]


id: GO:0044452
name: nucleolar part
namespace: cellular_component
def:
  "Any constituent part of a nucleolus, a small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis." [GOC:jl]


id: GO:0044453
name: nuclear membrane part
namespace: cellular_component
def:
  "Any constituent part of the nuclear membrane, the envelope that surrounds the nucleus of eukaryotic cells." [GOC:jl]


id: GO:0044454
name: nuclear chromosome part
namespace: cellular_component
def:
  "Any constituent part of a nuclear chromosome, a chromosome that encodes the nuclear genome and is found in the nucleus of a eukaryotic cell during the cell cycle phases when the nucleus is intact." [GOC:jl]


id: GO:0044455
name: mitochondrial membrane part
namespace: cellular_component
def:
  "Any constituent part of a mitochondrial membrane, either of the lipid bilayers that surround the mitochondrion and form the mitochondrial envelope." [GOC:jl]


id: GO:0044456
name: synapse part
namespace: cellular_component
def:
  "Any constituent part of a synapse, the junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell." [GOC:jl]


id: GO:0044457
name: cell septum part
namespace: cellular_component
def:
  "Any constituent part of a cell septum, a structure composed of peptidoglycan and often chitin in addition to other materials. It usually forms perpendicular to the long axis of a cell or hypha and grows centripetally from the cell wall to the center of the cell and often functions in the compartmentalization of a cell into two daughter cells." [GOC:jl]


id: GO:0044458
name: motile cilium assembly
namespace: biological_process
def:
  "The assembly of a motile cilium, a cilium that contains a regular longitudinal array of axonemal microtubules. In vertebrates, motile cilia are usually formed around a 9 + 2 microtubule core structure. Motile cilia are often found in tissues where propagation of fluid is necessary for proper organ development or function." [PMID:21129373, ZFIN:dsf]


id: GO:0044459
name: plasma membrane part
namespace: cellular_component
def:
  "Any constituent part of the plasma membrane, the membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [GOC:jl]


id: GO:0044460
name: obsolete flagellum part
namespace: cellular_component
def:
  "OBSOLETE. Any constituent part of a flagellum, a long whiplike or feathery structure borne either singly or in groups by the motile cells of many bacteria and unicellular eukaryotes and by the motile male gametes of many eukaryotic organisms, which propel the cell through a liquid medium." [GOC:jl]


id: GO:0044461
name: bacterial-type flagellum part
namespace: cellular_component
def:
  "Any constituent part of flagellum, a 20 nm diameter filament composed of subunits of flagellin driven passively at its base by a motor powered by the transmembrane proton potential. Examples of this component are found in bacterial species." [GOC:jl, GOC:mtg_sensu]


id: GO:0044462
name: external encapsulating structure part
namespace: cellular_component
def:
  "Any constituent part of an external encapsulating structure, a structure that lies outside the plasma membrane and surrounds the entire cell. This does not include the periplasmic space but does include the outer membrane (of gram negative bacteria) or cell wall (of yeast or Gram positive bacteria)." [GOC:jl]


id: GO:0044463
name: cell projection part
namespace: cellular_component
def:
  "Any constituent part of a cell projection, a prolongation or process extending from a cell, e.g. a flagellum or axon." [GOC:jl]


id: GO:0044464
name: cell part
namespace: cellular_component
def:
  "Any constituent part of a cell, the basic structural and functional unit of all organisms." [GOC:jl]


id: GO:0044465
name: modulation of sensory perception of pain in other organism
namespace: biological_process
def:
  "A process that modulates the frequency, rate or extent of the sensory perception of pain, the series of events required for an organism to receive a painful stimulus, convert it to a molecular signal, and recognize and characterize the signal, in a different organism." [GOC:ed, PMID:18579526]


id: GO:0044467
name: glial cell-derived neurotrophic factor secretion
namespace: biological_process
def:
  "The regulated release of glial cell line-derived neurotrophic factor from a cell. Glial cell-derived neurotrophic factor (GDNF) is a small protein that potently promotes the survival of many types of neurons, notably dopaminergic and motor neurons." [GOC:yaf, PMID:17505307]


id: GO:0044468
name: envenomation resulting in modulation of blood coagulation in other organism
namespace: biological_process
def:
  "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the modulation of the frequency, rate or extent of blood coagulation in the bitten organism." [GOC:jl]


id: GO:0044469
name: envenomation resulting in positive regulation of blood coagulation in other organism
namespace: biological_process
def:
  "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant activation, maintenance or an increase in the frequency, rate or extent of blood coagulation in the bitten organism." [GOC:jl]


id: GO:0044470
name: envenomation resulting in negative regulation of blood coagulation in other organism
namespace: biological_process
def:
  "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant stopping, prevention or reduction in the frequency, rate or extent of blood coagulation in the bitten organism." [GOC:jl]


id: GO:0044471
name: envenomation resulting in pore formation in membrane of other organism
namespace: biological_process
def:
  "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the aggregation, arrangement and bonding together of a set of components to form a pore complex in a membrane of the bitten organism." [GOC:fj, GOC:jl, PMID:21549739]


id: GO:0044472
name: envenomation resulting in modulation of calcium channel activity in other organism
namespace: biological_process
def:
  "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with a resultant change in the activity of a calcium channel in the bitten organism." [GOC:fj, GOC:jl, PMID:20920515]


id: GO:0044473
name: envenomation resulting in negative regulation of calcium channel activity in other organism
namespace: biological_process
def:
  "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant stopping, prevention or reduction of the activity of a calcium channel in the bitten organism." [GOC:fj, GOC:jl, PMID:20920515]


id: GO:0044474
namespace: biological_process
name:
  envenomation resulting in negative regulation of voltage-gated calcium channel activity in other organism

def:
  "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant stopping, prevention or reduction of the activity of a voltage-gated calcium channel in the bitten organism." [GOC:fj, GOC:jl, PMID:20920515]


id: GO:0044475
namespace: biological_process
name:
  envenomation resulting in negative regulation of high voltage-gated calcium channel activity in other organism

def:
  "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant stopping, prevention or reduction of the activity of a high voltage-gated calcium channel in the bitten organism." [GOC:fj, GOC:jl, PMID:20920515]


id: GO:0044476
namespace: biological_process
name:
  envenomation resulting in negative regulation of low voltage-gated calcium channel activity in other organism

def:
  "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant stopping, prevention or reduction of the activity of a low voltage-gated calcium channel in the bitten organism." [GOC:fj, GOC:jl, PMID:20920515]


id: GO:0044477
name: envenomation resulting in negative regulation of platelet aggregation in other organism
namespace: biological_process
def:
  "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant stopping, prevention or reduction in the frequency, rate or extent of platelet aggregation in the bitten organism." [GOC:fj, GOC:jl]


id: GO:0044478
name: envenomation resulting in positive regulation of platelet aggregation in other organism
namespace: biological_process
def:
  "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant activation, maintenance or an increase in the frequency, rate or extent of platelet aggregation in the bitten organism." [GOC:fj, GOC:jl]


id: GO:0044479
name: envenomation resulting in modulation of mast cell degranulation in other organism
namespace: biological_process
def:
  "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant modulation of blood mast cell degranulation in the bitten organism." [GOC:fj, GOC:jl, PMID:21549739]


id: GO:0044480
name: envenomation resulting in positive regulation of mast cell degranulation in other organism
namespace: biological_process
def:
  "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant positive regulation of blood mast cell degranulation in the bitten organism." [GOC:fj, GOC:jl, PMID:21549739]


id: GO:0044481
name: envenomation resulting in proteolysis in other organism
namespace: biological_process
def:
  "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant hydrolysis of proteins in of the bitten organism." [GOC:fj, GOC:jl, PMID:15922779]


id: GO:0044482
namespace: biological_process
name:
  envenomation resulting in blood vessel extracellular matrix damage, causing hemorrhagic damage in other organism

def:
  "A process that begins with venom being forced into an organism by the bite or sting of another organism which causes damage to the extracellular matrix of the blood vessels of the bitten organism, ultimately resulting in hemorrhage in the bitten organism." [GOC:fj, GOC:jl, PMID:10441379, PMID:19485419]


id: GO:0044483
name: envenomation resulting in impairment of hemostasis in other organism
namespace: biological_process
def:
  "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the inhibition of the process of hemostasis - the stopping of bleeding or the arrest of the circulation to an organ or part - in the bitten organism." [GOC:fj, GOC:jl]


id: GO:0044484
name: envenomation resulting in fibrinolysis in other organism
namespace: biological_process
def:
  "The process which begins with venom being forced into an organism by the bite or sting of another organism, and ends with fibrinolysis, a process that solubilizes fibrin, chiefly by the proteolytic action of plasmin, in the bloodstream of the bitten/stung organism." [GOC:fj, GOC:jl, PMID:17433397, PMID:17544404]


id: GO:0044485
name: envenomation resulting in fibrinogenolysis in other organism
namespace: biological_process
def:
  "The process which begins with venom being forced into an organism by the bite or sting of another organism, and ends with fibrinogenolysis, a process that degrades fibrinogen at a variety of Arg-Lys bonds, thus impairing fibrinogen clotting in the bloodstream of the bitten/stung organism." [GOC:fj, GOC:jl, PMID:17433397, PMID:17544404]


id: GO:0044486
name: modulation of transmission of nerve impulse in other organism
namespace: biological_process
def:
  "The process in which an organism effects a change in the transmission of a nerve impulse in another organism." [GOC:jl]


id: GO:0044487
name: envenomation resulting in modulation of transmission of nerve impulse in other organism
namespace: biological_process
def:
  "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant modulation of the transmission of nerve impulses in the bitten organism." [GOC:fj, GOC:jl]


id: GO:0044488
name: modulation of voltage-gated sodium channel activity in other organism
namespace: biological_process
def:
  "Any process in which an organism effects a change in the frequency, rate or extent of the activity of a voltage-gated sodium channel in another organism." [GOC:fj, GOC:jl, PMID:21781281]


id: GO:0044490
name: positive regulation of voltage-gated sodium channel activity in other organism
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of the activity of a voltage-gated sodium channel in another organism." [GOC:fj, GOC:jl, PMID:21781281]


id: GO:0044491
name: positive regulation of molecular function in other organism
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of the function of proteins in a second organism." [GOC:jl]


id: GO:0044492
name: envenomation resulting in modulation of voltage-gated sodium channel activity in other organism
namespace: biological_process
def:
  "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with a resultant change in the activity of a voltage-gated sodium channel in the bitten organism." [GOC:fj, GOC:jl, PMID:21781281]


id: GO:0044493
namespace: biological_process
name:
  envenomation resulting in negative regulation of voltage-gated sodium channel activity in other organism

def:
  "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant stopping, prevention or reduction of the activity of a voltage-gated sodium channel in the bitten organism." [GOC:fj, GOC:jl, PMID:21781281]


id: GO:0044494
namespace: biological_process
name:
  envenomation resulting in positive regulation of voltage-gated sodium channel activity in other organism

def:
  "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant activation or increase in the activity of the activity of a voltage-gated sodium channel in the bitten organism." [GOC:fj, GOC:jl, PMID:21781281]


id: GO:0044495
name: modulation of blood pressure in other organism
namespace: biological_process
def:
  "A process by which one organism modulates the force with which blood travels through the circulatory system of another organism." [GOC:fj, GOC:jl, PMID:19837656]


id: GO:0044496
name: negative regulation of blood pressure in other organism
namespace: biological_process
def:
  "A process by which one organism decreases the force with which blood travels through the circulatory system of another organism." [GOC:fj, GOC:jl, PMID:19837656]


id: GO:0044497
name: positive regulation of blood pressure in other organism
namespace: biological_process
def:
  "A process by which one organism increases the force with which blood travels through the circulatory system of another organism." [GOC:fj, GOC:jl, PMID:19837656]


id: GO:0044498
name: envenomation resulting in modulation of blood pressure in other organism
namespace: biological_process
def:
  "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant modulation of the force with which blood travels through the circulatory system of the bitten/stung organism." [GOC:fj, GOC:jl, PMID:19837656]


id: GO:0044499
name: envenomation resulting in positive regulation of blood pressure in other organism
namespace: biological_process
def:
  "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant increase of the force with which blood travels through the circulatory system of the bitten/stung organism." [GOC:fj, GOC:jl, PMID:19837656]


id: GO:0044500
name: envenomation resulting in negative regulation of blood pressure in other organism
namespace: biological_process
def:
  "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant decrease of the force with which blood travels through the circulatory system of the bitten/stung organism." [GOC:fj, GOC:jl, PMID:19837656]


id: GO:0044501
name: modulation of signal transduction in other organism
namespace: biological_process
def:
  "The process in which an organism effects a change in a signal transduction process - a cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell - in a second organism." [GOC:fj, GOC:jl]


id: GO:0044502
name: positive regulation of signal transduction in other organism
namespace: biological_process
def:
  "A process in which an organism activates, maintains or increases the frequency, rate or extent of a signal transduction process - a cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell - in a second organism." [GOC:fj, GOC:jl]


id: GO:0044503
name: modulation of G-protein coupled receptor activity in other organism
namespace: biological_process
def:
  "The process in which an organism effects a change in the activity of a G-protein coupled receptor in a second organism." [GOC:fj, GOC:jl, PMID:8405712]


id: GO:0044504
name: modulation of receptor activity in other organism
namespace: biological_process
def:
  "The process in which an organism effects a change in the activity of a receptor in a second organism." [GOC:fj, GOC:jl, PMID:8405712]


id: GO:0044505
name: positive regulation of G-protein coupled receptor activity in other organism
namespace: biological_process
def:
  "A process that activates or increases the frequency, rate or extent of the activity of a G-protein coupled receptor in a second organism." [GOC:fj, GOC:jl, PMID:8405712]


id: GO:0044506
name: modulation of glucagon-like peptide receptor 1 activity in other organism
namespace: biological_process
def:
  "The process in which an organism effects a change in the activity of a glucagon-like peptide receptor 1 in a second organism." [GOC:fj, GOC:jl, PMID:8405712]


id: GO:0044507
name: positive regulation of receptor activity in other organism
namespace: biological_process
def:
  "A process that activates or increases the frequency, rate or extent of the activity of a receptor in a second organism." [GOC:fj, GOC:jl, PMID:8405712]


id: GO:0044508
name: glucagon-like peptide 1 receptor activity
namespace: molecular_function
def:
  "Combining with glucagon-like peptide 1 and transmitting the signal across the membrane by activating an associated G-protein." [GOC:jl, PMID:12529935]


id: GO:0044509
name: envenomation resulting in modulation of signal transduction in other organism
namespace: biological_process
def:
  "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant modulation of signal transduction in the bitten organism." [GOC:fj, GOC:jl, PMID:8405712]


id: GO:0044510
name: envenomation resulting in positive regulation of signal transduction in other organism
namespace: biological_process
def:
  "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant positive regulation of signal transduction in the bitten organism." [GOC:fj, GOC:jl, PMID:8405712]


id: GO:0044511
name: envenomation resulting in modulation of receptor activity in other organism
namespace: biological_process
def:
  "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant modulation of receptor activity in of the bitten organism." [GOC:fj, GOC:jl, PMID:8405712]


id: GO:0044512
name: envenomation resulting in modulation of glucagon-like peptide receptor 1 activity in other organism
namespace: biological_process
def:
  "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant modulation of glucagon-like peptide receptor 1 activity in of the bitten organism." [GOC:fj, GOC:jl, PMID:8405712]


id: GO:0044513
name: envenomation resulting in modulation of G-protein coupled receptor activity in other organism
namespace: biological_process
def:
  "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant modulation of G-protein coupled receptor activity in of the bitten organism." [GOC:fj, GOC:jl, PMID:8405712]


id: GO:0044514
namespace: biological_process
name:
  envenomation resulting in positive regulation of G-protein coupled receptor activity in other organism

def:
  "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant positive regulation of G-protein coupled receptor activity in of the bitten organism." [GOC:fj, GOC:jl, PMID:8405712]


id: GO:0044515
namespace: biological_process
name:
  envenomation resulting in positive regulation of glucagon-like peptide receptor 1 activity in other organism

def:
  "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant positive regulation of glucagon-like peptide receptor 1 activity in of the bitten organism." [GOC:fj, GOC:jl, PMID:8405712]


id: GO:0044516
name: positive regulation of glucagon-like peptide receptor 1 activity in other organism
namespace: biological_process
def:
  "A process that activates or increases the frequency, rate or extent of the activity of a glucagon-like peptide receptor 1 in a second organism." [GOC:fj, GOC:jl, PMID:8405712]


id: GO:0044517
name: modulation of vasoactive intestinal polypeptide receptor activity in other organism
namespace: biological_process
def:
  "The process in which an organism effects a change in the activity of a vasoactive intestinal polypeptide receptor in a second organism." [GOC:fj, GOC:jl]


id: GO:0044518
name: positive regulation of vasoactive intestinal polypeptide receptor activity in other organism
namespace: biological_process
def:
  "A process that activates or increases the frequency, rate or extent of the activity of a vasoactive intestinal polypeptide receptor in a second organism." [GOC:fj, GOC:jl]


id: GO:0044519
namespace: biological_process
name:
  envenomation resulting in modulation of vasoactive intestinal polypeptide receptor activity in other organism

def:
  "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant modulation of the activity of a vasoactive intestinal polypeptide receptor in the bitten organism." [GOC:fj, GOC:jl]


id: GO:0044520
namespace: biological_process
name:
  envenomation resulting in positive regulation of vasoactive intestinal polypeptide receptor activity in other organism

def:
  "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant positive regulation of the activity of a vasoactive intestinal polypeptide receptor in the bitten organism." [GOC:fj, GOC:jl]


id: GO:0044521
name: envenomation resulting in muscle damage in other organism
namespace: biological_process
def:
  "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with resultant muscle damage in the bitten organism." [GOC:fj, GOC:jl, PMID:10620318, PMID:21150580]


id: GO:0044522
name: envenomation resulting in myocyte killing in other organism
namespace: biological_process
def:
  "A process that begins with venom being forced into an organism by the bite or sting of another organism, killing heart myocytes and ultimately resulting in muscle damage in the bitten organism." [GOC:fj, GOC:jl, PMID:10620318, PMID:21150580]


id: GO:0044523
name: envenomation resulting in damage of muscle extracellular matrix in other organism
namespace: biological_process
def:
  "A process that begins with venom being forced into an organism by the bite or sting of another organism, damaging the extracellular matrix of muscle cells and ultimately resulting in muscle necrosis in the bitten organism." [GOC:fj, GOC:jl, PMID:10620318, PMID:21150580]


id: GO:0044524
name: protein sulfhydration
namespace: biological_process
def:
  "The modification of a protein amino acid by the addition of sulfur." [GOC:jl, GOC:jsg, PMID:19903941, PMID:22169477, PMID:8161529]


id: GO:0044525
name: peptidyl-cystine sulfhydration
namespace: biological_process
def:
  "The modification of a peptidyl-cystine residue in a protein by the addition of sulfur, to form peptidyl-cysteine persulfide." [GOC:jl, GOC:jsg]


id: GO:0044526
name: formation of peptidyl-cystine persulfide by sulphur transfer from free cysteine
namespace: biological_process
def:
  "The modification of a peptidyl-cystine residue in a protein by the transfer of a sulfur atom from a free cysteine (in the process converting the free cysteine to alanine) to the peptidyl-cysteine to form peptidyl-cysteine persulfide." [GOC:jl, GOC:jsg]


id: GO:0044527
name: formation of peptidyl-cystine persulfide by sulphur transfer from H2S
namespace: biological_process
def:
  "The modification of a peptidyl-cystine residue in a protein by the direct addition of H2S, followed by the removal of 2 protons to form peptidyl-cysteine persulfide." [GOC:jl, GOC:jsg]


id: GO:0044528
name: regulation of mitochondrial mRNA stability
namespace: biological_process
def:
  "Any process that modulates the propensity of mitochondrial mRNA molecules to degradation. Includes processes that both stabilize and destabilize mitochondrial mRNAs." [GOC:al, GOC:jl]


id: GO:0044529
name: regulation of mitochondrial rRNA stability
namespace: biological_process
def:
  "Any process that modulates the propensity of mitochondrial rRNA molecules to degradation. Includes processes that both stabilize and destabilize mitochondrial rRNAs." [GOC:al, GOC:jl]


id: GO:0044530
name: supraspliceosomal complex
namespace: cellular_component
def:
  "Multicomponent complex of RNA and proteins that is composed of four active spliceosomes, termed native spliceosomes, connected to each other by the pre-mRNA. The supraspliceosome is the nuclear machine where the pre-mRNA processing takes place, like the 5'-end capping, 3'-end cleavage, splicing and editing." [GOC:ans, GOC:jl, PMID:19282290]


id: GO:0044531
name: modulation of programmed cell death in other organism
namespace: biological_process
def:
  "A process in which an organism modulates the frequency, rate or extent of programmed cell death in a second organism." [GOC:jl]


id: GO:0044532
name: modulation of apoptotic process in other organism
namespace: biological_process
def:
  "A process in which an organism modulates the frequency, rate or extent of apoptosis in a second organism." [GOC:jl]


id: GO:0044533
name: positive regulation of apoptotic process in other organism
namespace: biological_process
def:
  "Any process in which an organism activates, maintains or increases the frequency, rate or extent of programmed cell death by apoptosis in a second organism." [GOC:jl, PMID:17983639]


id: GO:0044534
name: envenomation resulting in modulation of apoptotic process in other organism
namespace: biological_process
def:
  "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant modulation of apoptosis in the bitten organism." [GOC:fj, GOC:jl, PMID:17983639]


id: GO:0044535
name: very-long-chain fatty acyl-CoA oxidase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: very-long-chain fatty acyl-CoA (C22 - C24) + O2 = trans-2,3-dehydroacyl-CoA + hydrogen peroxide." [PMID:17458872]


id: GO:0044536
name: envenomation resulting in depletion of circulating fibrinogen in other organism
namespace: biological_process
def:
  "The process which begins with venom being forced into an organism by the bite or sting of another organism, and ends with a reduction in the quantity of fibrinogen found in the bloodstream of the bitten/stung organism." [GOC:fj, GOC:jl]


id: GO:0044538
name: host cell periphery
namespace: cellular_component
def:
  "The part of a cell encompassing the cell cortex, the plasma membrane, and any external encapsulating structures of a host cell." [GOC:jl, PMID:20463076]


id: GO:0044539
name: long-chain fatty acid import
namespace: biological_process
def:
  "The directed movement of long-chain fatty acids into a cell or organelle. A long-chain fatty acid is a fatty acid with a chain length between C13 and C22." [GOC:jl, GOC:pm, PMID:22022213]


id: GO:0044540
name: L-cystine L-cysteine-lyase (deaminating)
namespace: molecular_function
def:
  "Catalysis of the reaction: L-cystine + H2O <=> pyruvate + NH3 + thiocysteine. Thiocysteine is also known as cysteine persulfide." [GOC:jl, RHEA:24930]


id: GO:0044541
name: zymogen activation in other organism
namespace: biological_process
def:
  "The chemical reactions and pathways performed by an organism resulting in the proteolytic processing of an inactive enzyme to an active form in another organism." [GOC:fj, GOC:jl]


id: GO:0044542
name: plasminogen activation in other organism
namespace: biological_process
def:
  "The chemical reactions and pathways performed by an organism resulting in the processing of inactive plasminogen to active plasmin in another organism." [GOC:fj, GOC:jl]


id: GO:0044543
name: envenomation resulting in zymogen activation in other organism
namespace: biological_process
def:
  "The process which begins with venom being forced into an organism by the bite or sting of another organism, and ends with the proteolytic processing of an inactive enzyme to an active form." [GOC:fj, GOC:jl]


id: GO:0044544
name: envenomation resulting in plasminogen activation in other organism
namespace: biological_process
def:
  "The process which begins with venom being forced into an organism by the bite or sting of another organism, and ends with the activation of plasminogen into plasmin in the bitten organism. This process includes cleavage at an internal Arg-Val site to form an N-terminal A-chain and C-terminal B-chain held together by a disulfide bond, and can include further proteolytic cleavage events to remove the preactivation peptide." [GOC:fj, GOC:jl]


id: GO:0044545
name: NSL complex
namespace: cellular_component
def:
  "A histone acetyltransferase complex that catalyzes the acetylation of a histone H4 lysine residues at several positions. In human, it contains the catalytic subunit MOF, NSL1/KIAA1267, NSL2/KANSL2, NSL3/KANSL3, MCRS1, PHF20, OGT1, WDR5 and HCF1." [GOC:lb, PMID:20018852]


id: GO:0044546
name: NLRP3 inflammasome complex assembly
namespace: biological_process
def:
  "The aggregation, arrangement and bonding together of a set of components to form the NLRP3 inflammasome complex, occurring at the level of an individual cell." [GOC:jl, PMID:21048113]


id: GO:0044548
name: S100 protein binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with a S100 protein. S100 is a small calcium and zinc binding protein produced in astrocytes that is implicated in Alzheimer's disease, Down Syndrome and ALS." [GOC:jid]


id: GO:0044550
name: secondary metabolite biosynthetic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of secondary metabolites, the compounds that are not necessarily required for growth and maintenance of cells, and are often unique to a taxon." [GOC:jl]


id: GO:0044551
name: envenomation resulting in modulation of vasodilation in other organism
namespace: biological_process
def:
  "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with resultant modulation of vasodilation of blood vessels, usually causing a reduction in blood pressure, in the bitten/stung organism." [GOC:ecd, GOC:jl, PMID:21050868]


id: GO:0044552
name: modulation of vasodilation in other organism
namespace: biological_process
def:
  "A process by which an organism causes vasodilation of blood vessels, usually causing a reduction in blood pressure, in another organism." [GOC:ecd, GOC:jl, PMID:21050868]


id: GO:0044553
name: modulation of biological quality in other organism
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of a biological quality in another organism. A biological quality is a measurable attribute of an organism or part of an organism, such as size, mass, shape, color, etc." [GOC:jl]


id: GO:0044554
name: modulation of heart rate in other organism
namespace: biological_process
def:
  "Any process that modulates the frequency or rate of heart contraction of another organism." [GOC:jl, PMID:20923766]


id: GO:0044555
name: negative regulation of heart rate in other organism
namespace: biological_process
def:
  "Any process that stops, prevents or reduces the frequency of heart contraction of another organism." [GOC:ecd, GOC:jl, PMID:20923766]


id: GO:0044556
name: envenomation resulting in negative regulation of heart rate of other organism
namespace: biological_process
def:
  "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the negative regulation of the heart rate of the bitten/stung organism." [GOC:ecd, GOC:jl, PMID:20923766]


id: GO:0044557
name: relaxation of smooth muscle
namespace: biological_process
def:
  "A process in which the extent of smooth muscle contraction is reduced. Smooth muscle differs from striated muscle in the much higher actin/myosin ratio, the absence of conspicuous sarcomeres and the ability to contract to a much smaller fraction of its resting length." [GOC:jl]


id: GO:0044559
name: envenomation resulting in modulation of voltage-gated potassium channel activity in other organism
namespace: biological_process
def:
  "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with a resultant change in the activity of a voltage-gated potassium channel in the bitten/stung organism." [GOC:fj, GOC:jl]


id: GO:0044560
name: envenomation resulting in modulation of ion channel activity in other organism
namespace: biological_process
def:
  "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with a resultant change in the activity of an ion channel in the bitten organism." [GOC:fj, GOC:jl]


id: GO:0044561
name: modulation of ion channel activity in other organism
namespace: biological_process
def:
  "Any process in which an organism effects a change in the frequency, rate or extent of the activity of an ion channel in another organism." [GOC:jl]


id: GO:0044562
namespace: biological_process
name:
  envenomation resulting in negative regulation of voltage-gated potassium channel activity in other organism

def:
  "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with a resultant negative regulation of the activity of a voltage-gated potassium channel in the bitten/stung organism." [GOC:fj, GOC:jl]


id: GO:0044563
namespace: biological_process
name:
  envenomation resulting in slowing of activation kinetics of voltage-gated potassium channel in other organism

def:
  "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with a resultant slowing of the activation kinetics of the activity of a voltage-gated potassium channel in the bitten/stung organism." [GOC:fj, GOC:jl]


id: GO:0044564
namespace: biological_process
name:
  envenomation resulting in occlusion of the pore of voltage-gated potassium channel in other organism

def:
  "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with a resultant blocking of a voltage-gated potassium channel, inhibiting the pore's activity, in the bitten/stung organism." [GOC:fj, GOC:jl]


id: GO:0044565
name: dendritic cell proliferation
namespace: biological_process
def:
  "The expansion of a dendritic cell population by cell division. A dendritic cell is a cell of hematopoietic origin, typically resident in particular tissues, specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation." [CL:0000451, PMID:18469816]


id: GO:0044566
name: chondrocyte activation
namespace: biological_process
def:
  "A change in the morphology or behavior of a chondrocyte resulting from exposure to an activating factor such as a cellular or soluble ligand. A chondrocyte is a polymorphic cell that forms cartilage." [CL:0000138, GOC:jl]


id: GO:0044567
name: primary cell wall cellulose synthase complex
namespace: cellular_component
def:
  "A large, multimeric protein complex which catalyzes the biosynthesis of cellulose for the plant primary cell wall. In Arabidopsis, contains the essential component proteins CESA1 and -3, and a CESA6-related protein." [GOC:mengo_curators, GOC:tt, PMID:17878302, PMID:21307367]


id: GO:0044568
name: secondary cell wall cellulose synthase complex
namespace: cellular_component
def:
  "A large, multimeric protein complex which catalyzes the biosynthesis of cellulose for the plant secondary cell wall. In Arabidopsis, contains the essential component proteins CESA8, CESA7, and CESA4." [GOC:mengo_curators, GOC:tt, PMID:21307367]


id: GO:0044569
name: [Ni-Fe] hydrogenase complex
namespace: cellular_component
def:
  "A microbial enzyme complex which contains nickel and iron in its active site. In Acetomicrobium flavidum it is an alpha 2 beta 2 tetramer." [GOC:mengo_curators, GOC:tt, PMID:8936309]


id: GO:0044570
name: starch utilization system complex
namespace: cellular_component
def:
  "A bacterial cell envelope-associated multiprotein system, which binds and degrades starch." [GOC:mengo_curators, GOC:tt, PMID:19553672]


id: GO:0044571
name: [2Fe-2S] cluster assembly
namespace: biological_process
def:
  "The incorporation of two iron atoms and two sulfur atoms into an iron-sulfur cluster." [GOC:jl, GOC:mengo_curators, GOC:pde, GOC:tt, GOC:vw, PMID:15952888]


id: GO:0044572
name: [4Fe-4S] cluster assembly
namespace: biological_process
def:
  "The incorporation of four iron atoms and four sulfur atoms into an iron-sulfur cluster." [GOC:jl, GOC:mengo_curators, GOC:pde, GOC:tt, GOC:vw, PMID:15952888]


id: GO:0044573
name: nitrogenase P cluster assembly
namespace: biological_process
def:
  "The biochemical reactions and pathways resulting in the formation of a P-cluster of a nitrogenase, a high-nuclearity, Fe/S-only cluster that can be viewed as two [4Fe-4S] sub-clusters sharing a gamma-6-sulfide." [PMID:17563349]


id: GO:0044574
name: starch utilization system complex assembly
namespace: biological_process
def:
  "The aggregation, arrangement and bonding together of the starch utilization system complex, a complex of cell envelope-associated proteins that degrades glycan." [GOC:mengo_curators, GOC:tt, PMID:19553672, PMID:21219452]


id: GO:0044575
name: cellulosome assembly
namespace: biological_process
def:
  "The assembly of a cellulosome, a macromolecular multi-enzyme complex in bacteria that facilitates the breakdown of cellulase, hemicellulase and pectin in the plant cell wall." [GOC:mengo_curators, GOC:tt, PMID:20373916]


id: GO:0044576
name: pentose catabolic process to ethanol
namespace: biological_process
def:
  "The anaerobic chemical reactions and pathways resulting in the breakdown of a pentose, any monosaccharide with a chain of five carbons, where one of the resulting products is ethanol." [GOC:mengo_curators, GOC:tt]


id: GO:0044577
name: xylose catabolic process to ethanol
namespace: biological_process
def:
  "The anaerobic chemical reactions and pathways resulting in the breakdown of xylose, an aldopentose, where one of the resulting products is ethanol." [GOC:mengo_curators, GOC:tt]


id: GO:0044579
name: butyryl-CoA biosynthetic process from acetyl-CoA
namespace: biological_process
def:
  "The chemical reactions and pathway resulting in the formation of butyryl-CoA, starting from acetyl-CoA." [GOC:mengo_curators, GOC:tt, PMID:19539744]


id: GO:0044581
name: butyryl-CoA catabolic process to butyrate
namespace: biological_process
def:
  "The chemical reactions a resulting in the resulting in the breakdown of butyryl-CoA to form butyrate." [GOC:mengo_curators, GOC:tt, PMID:19539744]


id: GO:0044582
name: butyryl-CoA catabolic process to butanol
namespace: biological_process
def:
  "The chemical reactions a resulting in the resulting in the breakdown of butyryl-CoA to form butanol." [GOC:mengo_curators, GOC:tt, PMID:19539744]


id: GO:0044584
name: cellodextrin binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with cellodextrin, a glucose polymer of 2 or more glucose monomers." [GOC:mengo_curators, GOC:tt, PMID:18952792]


id: GO:0044585
name: cellobiose binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with cellobiose, a disaccharide that represents the basic repeating unit of cellulose." [GOC:mengo_curators, GOC:tt]


id: GO:0044586
name: cellotetraose binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with cellotetraose, an oligosaccharide consisting of four glucose residues resulting from hydrolysis of cellulose." [GOC:mengo_curators, GOC:tt]


id: GO:0044587
name: cellopentaose binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with cellopentaose, an oligosaccharide consisting of four glucose residues resulting from hydrolysis of cellulose." [GOC:mengo_curators, GOC:tt]


id: GO:0044588
name: laminaribiose binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with laminaribiose, a disaccharide." [GOC:mengo_curators, GOC:tt]


id: GO:0044590
name: iron-sulfur-molybdenum cofactor binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with iron molybdenum cofactor, the cofactor located at the active site of the molybdenum nitrogenase." [GOC:mengo_curators, GOC:tt, PMID:18429691]


id: GO:0044591
name: response to amylopectin
namespace: biological_process
def:
  "A process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of amylopectin stimulus." [GOC:mengo_curators, GOC:tt]


id: GO:0044592
name: response to pullulan
namespace: biological_process
def:
  "A process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of pullulan stimulus." [GOC:mengo_curators, GOC:tt]


id: GO:0044593
name: iron-sulfur-molybdenum cofactor assembly
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of iron-sulfur-molybdenum cofactor, the cofactor located at the active site of the molybdenum nitrogenase." [GOC:mengo_curators, GOC:tt, PMID:18429691]


id: GO:0044594
name: 17-beta-hydroxysteroid dehydrogenase (NAD+) activity
namespace: molecular_function
def:
  "Catalysis of the reaction: a 17-beta-hydroxysteroid + NAD+ = a 17-oxosteroid + NADH + H+." [PMID:17074428]


id: GO:0044595
name: decaprenyldihydroxybenzoate methyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: S-adenosyl-L-methionine + 3-decaprenyl-4,5-dihydroxybenzoate = S-adenosyl-L-homocysteine + 3-decaprenyl-4-hydroxy-5-methoxybenzoate." [PMID:10777520]


id: GO:0044596
name: 3-demethylubiquinone-10 3-O-methyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: S-adenosyl-L-methionine + 3-demethylubiquinone-10 = S-adenosyl-L-homocysteine + ubiquinone-10." [PMID:10777520]


id: GO:0044597
name: daunorubicin metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving daunorubicin, a chemotherapeutic of the anthracycline family that is given as a treatment for some types of cancer." [CHEBI:41977]


id: GO:0044598
name: doxorubicin metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving doxorubicin, an anthracycline antibiotic, used in cancer chemotherapy." [CHEBI:28748]


id: GO:0044599
name: AP-5 adaptor complex
namespace: cellular_component
def:
  "An AP-type membrane coat adaptor complex that in humans consists of beta5, zeta, mu5 and sigma5 subunits and is found associated with membranes in the endosomes; it is not clear whether AP-5 forms clathrin coats in vivo." [PMID:22022230]


id: GO:0044600
name: protein guanylyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: GTP + protein = diphosphate + guanylyl-protein; mediates the addition of an guanylyl (guanosine 5'-monophosphate; GMP group) to specific residues of target proteins." [GOC:sp, PMID:20651120]


id: GO:0044602
name: protein deadenylylation
namespace: biological_process
def:
  "The removal of an adenylyl group (adenosine 5'-monophosphate; AMP) from a protein amino acid." [GOC:sp, PMID:21734656]


id: GO:0044603
name: protein adenylylhydrolase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: adenylyl-protein+ H2O = adenylate + protein; mediates the removal of an adenylyl (adenosine 5'-monophosphate; AMP group) from specific residues of target proteins." [PMID:21734656]


id: GO:0044604
name: phytochelatin transmembrane transporter ATPase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: ATP + H2O + phytochelatin (in) = ADP + phosphate + phytochelatin (out)." [GOC:al, PMID:7876244]


id: GO:0044605
name: phosphocholine transferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: CDP-choline + protein-serine = CMP + protein-serine-choline phosphate." [GOC:sp, PMID:21822290]


id: GO:0044606
name: phosphocholine hydrolase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: protein-serine-choline phosphate + H2O = protein-serine + choline phosphate." [GOC:sp, PMID:22158903]


id: GO:0044607
name: disruption by symbiont of host endothelial cells
namespace: biological_process
def:
  "Any process in which an organism has a negative effect on the functioning of the host's endothelial cells." [GOC:jl]


id: GO:0044608
name: peptidyl-L-threonine methyl ester biosynthetic process from peptidyl-threonine
namespace: biological_process
def:
  "The modification of a C-terminal peptidyl-threonine to form peptidyl-L-threonine methyl ester." [RESID:AA0507]


id: GO:0044609
name: DBIRD complex
namespace: cellular_component
def:
  "A protein complex that associates with mRNP particles and RNA polymerase II and is proposed to integrate transcript elongation with the regulation of alternative splicing. In humans it is composed of the proteins KIAA1967/DBC1 and ZNF326/ZIRD." [GOC:sp, PMID:22446626]


id: GO:0044610
name: FMN transmembrane transporter activity
namespace: molecular_function
def:
  "Enables the directed movement of flavine mononucleotide (FMN) into, out of or within a cell, or between cells." [GOC:ans, PMID:22185573]


id: GO:0044611
name: nuclear pore inner ring
namespace: cellular_component
def:
  "A subcomplex of the nuclear pore complex (NPC) that forms the inner rings of the core scaffold, a lattice-like structure that gives the NPC its shape and strength. In S. cerevisiae, the two inner rings are each composed of Nup192p, Nup188p, Nup170p and Nup157p. In vertebrates, the two inner rings are each composed of Nup205, Nup188 and Nup155. Components are arranged in 8-fold symmetrical 'spokes' around the central transport channel. A single 'spoke', can be isolated and is sometimes referred to as the Nup170 complex." [GOC:dgf, PMID:18046406, PMID:19524430, PMID:20947011, PMID:22419078]


id: GO:0044612
name: nuclear pore linkers
namespace: cellular_component
def:
  "A substructure of the nuclear pore complex (NPC) that serves to connect members of the central transport channel (composed of FG-nucleoporins) to the core scaffold (composed of the inner and outer NPC rings). In S. cerevisiae, the linkers are Nic96p and Nup82p. In vertebrates, they are Nup93 and Nup88. Components are arranged in 8-fold symmetrical 'spokes' around the central transport channel. Both linkers can be isolated in association with specific FG-nucleoporins, complexes that are sometimes referred to as the Nic96 complex (Nic96p-Nsp1p-Nup49p-Nup57p) and the Nup82 complex (Nup82p-Nup116p-Nup159p-Gle2p)." [GOC:dgf, PMID:18046406, PMID:19524430, PMID:20947011, PMID:22419078]


id: GO:0044613
name: nuclear pore central transport channel
namespace: cellular_component
def:
  "The central substructure of the nuclear pore complex (NPC), through which nucleocytoplasmic transport of RNAs, proteins and small molecules occurs. The central transport channel is filled with FG-nucleoporins, which form a selective barrier and provide a series of binding sites for transporter proteins. Characterized S. cerevisiae FG-nucleoporins include Nup159p, Nup145Np, Nup116p, Nup100p, Nsp1p, Nup57p, Nup49p, Nup42p, Nup53p, Nup59p/Asm4p, Nup60p and Nup1. Characterized vertebrate FG-nucleoporins include Nup214, Nup98, Nup62, Nup54, Nup58/45, NLP1, and Nup153." [GOC:dgf, PMID:18046406, PMID:19524430, PMID:20947011, PMID:22419078]


id: GO:0044614
name: nuclear pore cytoplasmic filaments
namespace: cellular_component
def:
  "Filamentous extensions on cytoplasmic face of the nuclear pore complex (NPC). In S. cerevisiae, Nup159p, Nup82p, and Nup42p contribute to the cytoplasmic filaments. In vertebrates, Nup358 is a major component." [GOC:dgf, PMID:18046406, PMID:19524430, PMID:20947011, PMID:22419078]


id: GO:0044615
name: nuclear pore nuclear basket
namespace: cellular_component
def:
  "A filamentous, cage-like assembly on the nuclear face of the nuclear pore complex (NPC). In S. cerevisiae, Mlp1p and Mlp2p are two major components of the NPC nuclear basket. In vertebrates, Tpr is a major component." [GOC:dgf, PMID:18046406, PMID:19524430, PMID:20947011, PMID:22419078]


id: GO:0044616
name: modulation of relaxation of muscle in other organism
namespace: biological_process
def:
  "The process in which an organism effects a change in the relaxation of muscle in a second organism." [GOC:jl]


id: GO:0044617
name: modulation of relaxation of smooth muscle in other organism
namespace: biological_process
def:
  "The process in which an organism effects a change in the relaxation of smooth muscle in a second organism." [GOC:jl]


id: GO:0044618
name: modulation of relaxation of uterine smooth muscle in other organism
namespace: biological_process
def:
  "The process in which an organism effects a change in the relaxation of smooth muscle in the uterus of a second organism." [GOC:jl]


id: GO:0044620
name: ACP phosphopantetheine attachment site binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with the attachment site of the phosphopantetheine prosthetic group of an acyl carrier protein (ACP)." [GOC:jl, GOC:vw]


id: GO:0044621
name: modulation of cell migration in other organism
namespace: biological_process
def:
  "The process in which an organism effects a change in the process of cell migration in a second organism." [GOC:jl]


id: GO:0044622
name: negative regulation of cell migration in other organism
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of cell migration in a second organism." [GOC:jl]


id: GO:0044623
name: positive regulation of cell migration in other organism
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of cell migration in a second organism." [GOC:jl]


id: GO:0044624
name: envenomation resulting in modulation of cell migration in other organism
namespace: biological_process
def:
  "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the modulation of cell migration in the bitten organism." [GOC:jl, PMID:19932752]


id: GO:0044625
name: envenomation resulting in negative regulation of cell migration in other organism
namespace: biological_process
def:
  "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the negative regulation of cell migration in the bitten organism." [GOC:jl, PMID:19932752]


id: GO:0044626
name: envenomation resulting in positive regulation of cell migration in other organism
namespace: biological_process
def:
  "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the positive regulation of cell migration in the bitten organism." [GOC:jl, PMID:19932752]


id: GO:0044627
name: modulation of complement activation, classical pathway in other organism
namespace: biological_process
def:
  "A process that modulates the frequency, rate or extent of the classical pathway of complement activation, in a different organism." [GOC:jl, PMID:20837040]


id: GO:0044628
name: positive regulation of complement activation, classical pathway in other organism
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of complement activation by the classical pathway, in a different organism." [GOC:jl, PMID:20837040]


id: GO:0044629
name: negative regulation of complement activation, classical pathway in other organism
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of complement activation by the classical pathway, in a different organism." [GOC:jl, PMID:20837040]


id: GO:0044630
name: modulation of complement activation, lectin pathway in other organism
namespace: biological_process
def:
  "A process that modulates the frequency, rate or extent of the lectin pathway of complement activation, in a different organism." [GOC:jl, PMID:20837040]


id: GO:0044631
name: positive regulation of complement activation, lectin pathway in other organism
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of complement activation by the lectin pathway, in a different organism." [GOC:jl, PMID:20837040]


id: GO:0044632
name: negative regulation of complement activation, lectin pathway in other organism
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the rate of complement activation by the lectin pathway, in a different organism." [GOC:jl, PMID:20837040]


id: GO:0044633
name: modulation of complement activation, alternative pathway in other organism
namespace: biological_process
def:
  "A process that modulates the frequency, rate or extent of complement activation, via the alternative pathway, in a different organism." [GOC:jl, PMID:20837040]


id: GO:0044634
name: negative regulation of complement activation, alternative pathway in other organism
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of complement activation by the alternative pathway, in a different organism." [GOC:jl, PMID:20837040]


id: GO:0044635
name: positive regulation of complement activation, alternative pathway in other organism
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of complement activation by the alternative pathway, in a different organism." [GOC:jl, PMID:20837040]


id: GO:0044636
name: envenomation resulting in modulation of complement activation, classical pathway in other organism
namespace: biological_process
def:
  "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the regulation of complement activation via the classical pathway of the bitten/stung organism." [GOC:fj, GOC:jl, PMID:20837040]


id: GO:0044637
namespace: biological_process
name:
  envenomation resulting in negative regulation of complement activation, classical pathway in other organism

def:
  "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the negative regulation of complement activation via the classical pathway of the bitten/stung organism." [GOC:fj, GOC:jl, PMID:20837040]


id: GO:0044638
namespace: biological_process
name:
  envenomation resulting in positive regulation of complement activation, classical pathway in other organism

def:
  "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the positive regulation of complement activation via the classical pathway of the bitten/stung organism." [GOC:fj, GOC:jl, PMID:20837040]


id: GO:0044639
name: envenomation resulting in modulation of complement activation, lectin pathway in other organism
namespace: biological_process
def:
  "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant modulation of complement activation via the lectin pathway in the bitten/stung organism." [GOC:fj, GOC:jl, PMID:20837040]


id: GO:0044640
namespace: biological_process
name:
  envenomation resulting in negative regulation of complement activation, lectin pathway in other organism

def:
  "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant negative regulation of complement activation via the lectin pathway in the bitten/stung organism." [GOC:fj, GOC:jl, PMID:20837040]


id: GO:0044641
namespace: biological_process
name:
  envenomation resulting in positive regulation of complement activation, lectin pathway in other organism

def:
  "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant positive regulation of complement activation via the lectin pathway in the bitten/stung organism." [GOC:fj, GOC:jl, PMID:20837040]


id: GO:0044642
namespace: biological_process
name:
  envenomation resulting in modulation of complement activation, alternative pathway in other organism

def:
  "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant modulation of complement activation via the alternative pathway in the bitten/stung organism." [GOC:fj, GOC:jl, PMID:20837040]


id: GO:0044643
namespace: biological_process
name:
  envenomation resulting in positive regulation of complement activation, alternative pathway in other organism

def:
  "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant positive regulation of complement activation via the alternative pathway in the bitten/stung organism." [GOC:fj, GOC:jl, PMID:20837040]


id: GO:0044644
namespace: biological_process
name:
  envenomation resulting in negative regulation of complement activation, alternative pathway in other organism

def:
  "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant negative regulation of complement activation via the alternative pathway in the bitten/stung organism." [GOC:fj, GOC:jl, PMID:20837040]


id: GO:0044645
name: modulation of complement activation in other organism
namespace: biological_process
def:
  "A process that modulates the frequency, rate or extent of complement activation in a different organism." [GOC:fj, GOC:jl, PMID:20837040]


id: GO:0044646
name: envenomation resulting in modulation of complement activation in other organism
namespace: biological_process
def:
  "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the resultant modulation of complement activation in the bitten/stung organism." [GOC:fj, GOC:jl, PMID:20837040]


id: GO:0044647
name: host-symbiont bicellular tight junction
namespace: cellular_component
def:
  "An occluding cell-cell junction formed between the membranes of the apical end of an invading cell (e.g. a merozoite in Plasmodium) and a host target cell (e.g. erythrocyte for Plasmodium infection). The junction is a stable yet dynamic structure that moves around the symbiont cell during invasion, enclosing it in a vacuole surrounded by a membrane." [GOC:jl, PMID:21803641]


id: GO:0044648
name: histone H3-K4 dimethylation
namespace: biological_process
def:
  "The modification of histone H3 by addition of two methyl groups to lysine at position 4 of the histone." [GOC:jl, PMID:21875999]


id: GO:0044649
name: envenomation resulting in cytolysis in other organism
namespace: biological_process
def:
  "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with cytolysis in the bitten organism." [GOC:fj, GOC:jl, PMID:22484288]


id: GO:0044650
name: adhesion of symbiont to host cell
namespace: biological_process
def:
  "The attachment of a symbiont to a host cell via adhesion molecules, general stickiness etc., either directly or indirectly." [GOC:jl]


id: GO:0044651
name: adhesion of symbiont to host epithelial cell
namespace: biological_process
def:
  "The attachment of a symbiont to a host epithelial cell via adhesion molecules, general stickiness etc., either directly or indirectly." [GOC:jl, PMID:10066176]


id: GO:0044652
name: adhesion of symbiont to host endothelial cell
namespace: biological_process
def:
  "The attachment of a symbiont to a host endothelial cell via adhesion molecules, general stickiness etc., either directly or indirectly." [GOC:jl, PMID:10066176]


id: GO:0044655
name: phagosome reneutralization
namespace: biological_process
def:
  "Any process that increases the pH of the phagosome, measured by the concentration of the hydrogen ion, as part of the process of phagosome maturation." [GOC:rjd, PMID:22008230]


id: GO:0044656
name: regulation of post-lysosomal vacuole size
namespace: biological_process
def:
  "Any process that modulates the volume of a post-lysosomal vacuole, a membrane-bounded intracellular vesicle formed late in the endocytic pathway when the pH in the vacuole becomes neutral prior to exocytosis." [GOC:rjd, PMID:22008230]


id: GO:0044657
name: pore formation in membrane of other organism during symbiotic interaction
namespace: biological_process
def:
  "The aggregation, arrangement and bonding together of a set of components by an organism to form a pore complex in a membrane of another organism, occurring as part of a symbiotic interaction." [GOC:jl]


id: GO:0044658
name: pore formation in membrane of host by symbiont
namespace: biological_process
def:
  "The aggregation, arrangement and bonding together of a set of components by an organism to form a pore complex in a membrane of a host organism." [GOC:jl]


id: GO:0044659
name: cytolysis by virus of host cell
namespace: biological_process
def:
  "The killing by a virus of a cell in its host organism by means of the rupture of cell membranes and the loss of cytoplasm." [GOC:jl]


id: GO:0044660
name: cytolysis by virus via pore formation in host cell membrane
namespace: biological_process
def:
  "The killing by a virus of a cell in its host organism by cytolysis, caused by the formation by the virus of pores in its host cell membrane." [GOC:jl]


id: GO:0044662
name: disruption by virus of host cell membrane
namespace: biological_process
def:
  "A process by which a virus has a negative effect on the functioning of a host cellular membrane." [GOC:jl]


id: GO:0044663
name: establishment or maintenance of cell type involved in phenotypic switching
namespace: biological_process
def:
  "A cellular process of the specification, formation or maintenance of an alternative cell type, occurring as part of the process of phenotypic switching. Phenotypic switching begins with changes in cell morphology and altered gene expression patterns and ends when the morphology of a population of cells has reverted back to the default state, accompanied by altered expression patterns." [GOC:jl]


id: GO:0044664
name: reversion of cell type to default state involved in phenotypic switching
namespace: biological_process
def:
  "The cellular process of the reversion of cells to their original cell type, occurring as part of the process of phenotypic switching. Phenotypic switching begins with changes in cell morphology and altered gene expression patterns and ends when the morphology of a population of cells has reverted back to the default state, accompanied by altered expression patterns." [GOC:jl]


id: GO:0044665
name: MLL1/2 complex
namespace: cellular_component
def:
  "A protein complex that can methylate lysine-4 of histone H3, and which contains either of the protein subunits MLL1 or MLL2 in human, or equivalent in other species." [GOC:sart, PMID:21875999]


id: GO:0044666
name: MLL3/4 complex
namespace: cellular_component
def:
  "A protein complex that can methylate lysine-4 of histone H3, and which contains either of the protein subunits MLL3 or MLL4 in mammals, or equivalent in other species." [GOC:sart, PMID:21875999]


id: GO:0044667
name: (R)-carnitine:4-(trimethylammonio)butanoate antiporter activity
namespace: molecular_function
def:
  "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: (R)-carnitine(out) + 4-(trimethylammonio)butanoate(in) = (R)-carnitine(in) + 4-(trimethylammonio)butanoate(out)." [GOC:crds]


id: GO:0044668
name: sodium:malonate symporter activity
namespace: molecular_function
def:
  "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sodium(out)+ malonate(out) = sodium(in) + malonate(in)." [GOC:crds]


id: GO:0044669
name: sodium:galactoside symporter activity
namespace: molecular_function
def:
  "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sodium(out)+ galactoside(out) = sodium(in) + galactoside(in)." [GOC:crds]


id: GO:0044670
name: sodium:alanine symporter activity
namespace: molecular_function
def:
  "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sodium(out)+ alanine(out) = sodium(in) + alanine(in)." [GOC:crds]


id: GO:0044671
name: sorocarp spore cell differentiation
namespace: biological_process
def:
  "The process in which a relatively unspecialized cell acquires specialized features of a sorocarp spore cell, a cell of the sorocarp sorus. A sorocarp is the fruiting body characteristic of certain cellular slime moulds (e.g., Dictyosteliida) and consists of both stalk and a sorus (spore mass)." [GOC:jl, GOC:rjd]


id: GO:0044672
name: acetyl-CoA decarbonylase/synthase-carbon monoxide dehydrogenase complex
namespace: cellular_component
def:
  "A multifunctional enzyme complex composed of five different polypeptides that catalyzes the decarbonylation of acetyl-CoA, cleaves the C-C and C-S bonds in the acetyl moiety of acetyl-CoA, oxidizes the carbonyl group to CO2 and transfers the methyl group to tetrahydrosarcinapterin. These reactions are important for methanogenesis." [GOC:mengo_curators, PMID:11607176, PMID:7693685, PMID:8955306]


id: GO:0044673
name: 7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase complex
namespace: cellular_component
def:
  "A heterodimer which catalyses the reaction of 5-amino-6-(D-ribitylamino)uracil and 4-hydroxyphenylpyruvate to form 7,8-didemethyl-8-hydroxy-5-deazariboflavin (FO), an intermediate of coenzyme F420." [GOC:mengo_curators, PMID:14593448]


id: GO:0044674
name: methyl coenzyme M reductase complex
namespace: cellular_component
def:
  "A hexameric complex consisting of three polypeptides in an alpha2beta2gamma2 arrangement. Involved in the reduction of the coenzyme M-bound methyl group to methane, which is the final step in methanogenesis." [GOC:mengo_curators, PMID:9367957]


id: GO:0044675
name: formyl-methanofuran dehydrogenase (tungsten enzyme) complex
namespace: cellular_component
def:
  "A protein complex consisting of four polypeptides which also contains tungsten, a molybdopterin guanine dinucleotide, and iron-sulfur clusters. This protein complex catalyzes the reversible conversion of CO2 and methanofuran to formylmethanofuran during methanogenesis." [GOC:mengo_curators, PMID:8125106, PMID:8575452]


id: GO:0044676
name: formyl-methanofuran dehydrogenase (molybdenum enzyme) complex
namespace: cellular_component
def:
  "A protein complex consisting of three polypeptides which also contains molybdenum, a molybdopterin guanine dinucleotide and iron-sulfur clusters. This protein complex catalyzes the reversible conversion of CO2 and methanofuran to formylmethanofuran during methanogenesis." [GOC:mengo_curators, PMID:1915887, PMID:8954165]


id: GO:0044677
name: methyl-tetrahydromethanopterin:coenzyme M methyltransferase complex
namespace: cellular_component
def:
  "A protein complex consisted of eight polypeptides. This complex catalyzes the formation of methyl-coenzyme M and H4MPT from N5-methyl-H4MPT and CoM during methanogenesis." [GOC:mengo_curators, PMID:8477726]


id: GO:0044678
name: CoB-CoM heterodisulfide reductase complex
namespace: cellular_component
def:
  "A protein complex that in Methanobacterium thermoautotrophicum is composed of six subunits, and in Methanosarcina barkeri contains is composed of either two subunits or nine subunits. Catalyzes the conversion of coenzyme B, coenzyme M, and methanophenazine to form N-{7-[(2-sulfoethyl)dithio]heptanoyl}-3-O-phospho-L-threonine and dihydromethanophenazine." [GOC:mengo_curators, PMID:8119281, PMID:8174566, PMID:9063468]


id: GO:0044679
name: methanophenazine reducing hydrogenase complex
namespace: cellular_component
def:
  "A protein complex which catalyzes the conversion of methanophenazine and hydrogen to form dihydromethanophenazine. This typically consists of three polypeptides" [GOC:mengo_curators, PMID:9555882]


id: GO:0044680
name: methylthiol:coenzyme M methyltransferase complex
namespace: cellular_component
def:
  "A protein complex of two polypeptides which catalyzes the transfer of methyl group from methylthiol to coenzyme M during methanogenesis." [GOC:mengo_curators, PMID:11073950, PMID:9371433]


id: GO:0044681
name: sulfopyruvate decarboxylase complex
namespace: cellular_component
def:
  "A complex of two polypeptides which form a dodecamer (A6B6). Catalyzes the decarboxylation of sulfopyruvic acid to sulfoacetaldehyde. This reaction is involved in coenzyme M biosynthesis." [GOC:mengo_curators, PMID:10940029]


id: GO:0044682
name: archaeal-specific GTP cyclohydrolase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: GTP + H2O <=> 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate + diphosphate +formate + H+. This activity is part of the biosynthesis of methanopterin in Archaea, and requires Fe2+." [GOC:mengo_curators, PMID:17497938]


id: GO:0044683
name: methylthiol:coenzyme M methyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the overall reaction: methyl-Co(III) methylated-thiol-specific corrinoid protein + coenzyme M = Co(I) methylated--thiol-specific corrinoid protein + methyl-CoM." [MetaCyc:RXN-8125, PMID:9371433]


id: GO:0044684
name: dihydromethanopterin reductase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 7,8-dihydromethanopterin + NADPH = 5,6,7,8-tetrahydromethanopterin + NADP." [GOC:mengo_curators, PMID:15028691]


id: GO:0044685
name: tetrahydromethanopterin-dependent serine hydroxymethyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: tetrahydromethanopterin + L-serine = 5,10-methylenetetrahydromethanopterin + glycine + H2O." [GOC:mengo_curators, PMID:12902326]


id: GO:0044686
name: cysteate synthase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: L-phosphoserine + SO32- = L-cysteate + HPO4-." [GOC:mengo_curators, PMID:19761441]


id: GO:0044687
name: geranylfarnesyl diphosphate synthase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: geranylgeranyl diphosphate + isopentenyl diphosphate = (2E,6E,10E,14E)-geranylfarnesyl diphosphate + diphosphate." [GOC:mengo_curators, PMID:20097171]


id: GO:0044688
name: 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate phosphodiesterase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate + H2O = 7,8-dihydroneopterin 3'-phosphate + H+." [GOC:mengo_curators, PMID:19746965]


id: GO:0044689
name: 7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 5-amino-6-(D-ribitylamino)uracil + 4-hydroxyphenylpyruvate + 2 S-adenosyl-L-methionine + H2O = 7,8-didemethyl-8-hydroxy-5-deazariboflavin + 2 5'-deoxyadenosine + 2 L-methionine + oxalate + ammonia + 4 H+." [GOC:mengo_curators, PMID:11948155, PMID:14593448]


id: GO:0044691
name: tooth eruption
namespace: biological_process
def:
  "The tooth development process in which the teeth enter the mouth and become visible." [Wikipedia:Tooth_eruption]


id: GO:0044693
name: trehalose:proton symporter activity
namespace: molecular_function
def:
  "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: trehalose(out) + H+(out) = trehalose(in) + H+(in)." [PMID:11136464]


id: GO:0044694
name: pore-mediated entry of viral genome into host cell
namespace: biological_process
def:
  "Injection by a non-enveloped virus of the viral genome into the host cytoplasm through creation of a pore or channel in the host cell membrane(s). Usually mediated by a viral pore-forming peptide associated with the viral capsid or bacteriophage tail." [GOC:jl, UniProtKB-KW:KW-1172, VZ:979]


id: GO:0044695
name: Dsc E3 ubiquitin ligase complex
namespace: cellular_component
def:
  "An E3 ubiquitin ligase complex localized to the ER and Golgi membrane. In fission yeast comprises Dsc1, 2, 3 and 4. Involved in the processes of fission yeast sre1 (human SREBP) transcriptional activator proteolytic cleavage, the multivesicular body (MVB) pathway, and a post-endoplasmic reticulum pathway for protein catabolism." [GOC:mah, GOC:vw, PMID:21504829]


id: GO:0044696
name: killing by virus of host cell by post-segregational killing
namespace: biological_process
def:
  "The process by which a virus causes the death of daughter cells which do not contain its genes after host cell division, by a mechanism of post-segregational killing (PSK). The extrachromosomal viral DNA consist of two genes; the product of the second is long lived and toxic, while the product of the first is short lived and antagonizes the lethal action of the toxin. Daughter cells that do not contain the viral extrachromosomal element are killed by the long lived toxin, while daughter cells that do contain the viral extrachromosomal element are protected by the action of the short lived antitoxin it encodes." [GOC:bf, GOC:jl, PMID:11222604, Wikipedia:Toxin-antitoxin_system]


id: GO:0044697
name: HICS complex
namespace: cellular_component
def:
  "A multisubunit complex involved in cytokinesis. In the yeast Saccharomyces cerevisiae this complex consists of Sho1p, Hof1p, Inn1p and Cyk3p proteins." [PMID:22623719]


id: GO:0044698
name: morphogenesis of symbiont in host cell
namespace: biological_process
def:
  "The process in which a symbiont undergoes a change in shape or form, within the host's cell." [GOC:jl]


id: GO:0044702
name: single organism reproductive process
namespace: biological_process
def:
  "A biological process that directly contributes to the process of producing new individuals, involving a single organism." [GOC:jl]


id: GO:0044703
name: multi-organism reproductive process
namespace: biological_process
def:
  "A biological process that directly contributes to the process of producing new individuals, involving another organism." [GOC:jl]


id: GO:0044704
name: single-organism reproductive behavior
namespace: biological_process
def:
  "The specific behavior of an organism that is associated with reproduction involving a single organism." [GOC:jl, GOC:pr]


id: GO:0044705
name: multi-organism reproductive behavior
namespace: biological_process
def:
  "The specific behavior of an organism that is associated with reproduction involving another organism of the same or different species." [GOC:jl, GOC:pr]


id: GO:0044706
name: multi-multicellular organism process
namespace: biological_process
def:
  "A multicellular organism process which involves another multicellular organism of the same or different species." [GOC:jl]


id: GO:0044708
name: single-organism behavior
namespace: biological_process
def:
  "The specific behavior of a single organism in response to external or internal stimuli." [GOC:jl, GOC:pr]


id: GO:0044710
name: single-organism metabolic process
namespace: biological_process
def:
  "A metabolic process - chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances - which involves a single organism." [GOC:jl]


id: GO:0044711
name: single-organism biosynthetic process
namespace: biological_process
def:
  "A biosynthetic process - chemical reactions and pathways resulting in the formation of substances - involving a single organism." [GOC:jl]


id: GO:0044712
name: single-organism catabolic process
namespace: biological_process
def:
  "A catabolic process - chemical reactions and pathways resulting in the breakdown of substances - which involves a single organism." [GOC:jl]


id: GO:0044713
name: 2-hydroxy-adenosine triphosphate pyrophosphatase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 2-hydroxy-adenosine-triphosphate + H2O = 2-hydroxy-adenosine phosphate + diphosphate." [GOC:pde, PMID:11139615]


id: GO:0044714
name: 2-hydroxy-(deoxy)adenosine-triphosphate pyrophosphatase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 2-hydroxy-(deoxy)adenosine-triphosphate + H2O = 2-hydroxy-(deoxy)adenosine phosphate + diphosphate." [GOC:pde, PMID:11139615]


id: GO:0044717
name: 8-hydroxy-dADP phosphatase activity
namespace: molecular_function
def:
  "Catalysis of the reaction8-hydroxy-dADP + H2O = 8-hydroxy-dAMP + phosphate." [GOC:pde, PMID:22556419]


id: GO:0044718
name: siderophore transmembrane transport
namespace: biological_process
def:
  "The directed movement of siderophores, low molecular weight Fe(III)-chelating substances, from one side of a membrane to the other, by means of some agent such as a transporter or pore." [GOC:jl]


id: GO:0044721
name: protein import into peroxisome matrix, substrate release
namespace: biological_process
def:
  "The process by which the cargo protein is released into the peroxisomal matrix, following translocation across the membrane." [PMID:21976670]


id: GO:0044723
name: single-organism carbohydrate metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving carbohydrates, occurring within a single organism." [GOC:jl]


id: GO:0044724
name: single-organism carbohydrate catabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the breakdown of carbohydrates, occurring within a single organism." [GOC:jl]


id: GO:0044725
name: chromatin reprogramming in the zygote
namespace: biological_process
def:
  "The global reprogramming of epigenetic modifications in the zygote following fertilization. The paternal genome undergoes active DNA demethylation before the first cell division, while the adjacent maternal genome is protected from this process." [GOC:sp, PMID:22868271]


id: GO:0044726
name: protection of DNA demethylation of female pronucleus
namespace: biological_process
def:
  "The protection of the maternal genome from DNA demethylation in the zygote following fertilization." [GOC:sp, PMID:22868271]


id: GO:0044727
name: DNA demethylation of male pronucleus
namespace: biological_process
def:
  "The active DNA demethylation of the paternal genome that takes place before the first cell division." [GOC:sp, PMID:22868271]


id: GO:0044728
name: DNA methylation or demethylation
namespace: biological_process
def:
  "The process of adding or removing a methyl group from one or more nucleotides within an DNA molecule." [GOC:jl]


id: GO:0044729
name: hemi-methylated DNA-binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with double-stranded hemi-methylated DNA at replication foci (one strand methylated, while the other strand is unmethylated). Methylation of cytosine or adenine in DNA is an important mechanism for establishing stable heritable epigenetic marks." [GOC:imk, GOC:sp, PMID:18772889]


id: GO:0044730
name: bone sialoprotein binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with a bone sialoprotein, an extracellular matrix glycoprotein found on the surface of bones and dentin." [PMID:10642520]


id: GO:0044731
name: Ost-alpha/Ost-beta complex
namespace: cellular_component
def:
  "A heterodimeric protein complex composed of Ost-alpha/SLC51A and Ost-beta/SLC51B subunits and involved in bile acid transport activity." [PMID:17650074, PMID:22535958]


id: GO:0044732
name: mitotic spindle pole body
namespace: cellular_component
def:
  "The microtubule organizing center on a spindle that forms as part of mitosis; functionally homologous to the animal cell centrosome." [GOC:vw]


id: GO:0044733
name: envenomation resulting in modulation of acid-sensing ion channel activity in other organism
namespace: biological_process
def:
  "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with a resultant change in the activity of an acid-sensing ion channel (ASIC) in the bitten organism." [GOC:fj, GOC:jl, PMID:23034652]


id: GO:0044734
namespace: biological_process
name:
  envenomation resulting in positive regulation of acid-sensing ion channel activity in other organism

def:
  "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with a resultant positive regulation in the activity of an acid-sensing ion channel (ASIC) in the bitten organism." [GOC:fj, GOC:jl, PMID:23034652]


id: GO:0044735
namespace: biological_process
name:
  envenomation resulting in negative regulation of acid-sensing ion channel activity in other organism

def:
  "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with a resultant negative regulation in the activity of an acid-sensing ion channel (ASIC) in the bitten organism." [GOC:fj, GOC:jl, PMID:23034652]


id: GO:0044736
name: acid-sensing ion channel activity
namespace: molecular_function
def:
  "Enables the transmembrane transfer of a sodium ion by a neuronal, voltage-insensitive channel that opens when a an extracellular proton has been bound by the channel complex." [GOC:jl]


id: GO:0044737
name: modulation of acid-sensing ion channel in other organism
namespace: biological_process
def:
  "Any process in which an organism effects a change in the frequency, rate or extent of the activity of an acid-sensing ion channel (ASIC) in another organism." [GOC:jl]


id: GO:0044738
name: negative regulation of acid-sensing ion channel in other organism
namespace: biological_process
def:
  "Any process in which an organism negatively regulates the activity of a voltage-gated sodium channel in another organism." [GOC:jl]


id: GO:0044739
name: positive regulation of acid-sensing ion channel in other organism
namespace: biological_process
def:
  "Any process in which an organism positively regulates the activity of a voltage-gated sodium channel in another organism." [GOC:jl]


id: GO:0044740
name: negative regulation of sensory perception of pain in other organism
namespace: biological_process
def:
  "A process that negatively regulates the sensory perception of pain in a different organism." [GOC:fj, GOC:jl]


id: GO:0044741
name: envenomation resulting in negative regulation of sensory perception of pain in other organism
namespace: biological_process
def:
  "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the inhibition of the sensory perception of pain in the bitten organism." [GOC:fj, GOC:jl, PMID:23034652]


id: GO:0044742
name: envenomation resulting in modulation of sensory perception of pain in other organism
namespace: biological_process
def:
  "A process that begins with venom being forced into an organism by the bite or sting of another organism, and ends with the modulation of the sensory perception of pain in the bitten organism." [GOC:fj, GOC:jl, PMID:23034652]


id: GO:0044744
name: protein targeting to nucleus
namespace: biological_process
def:
  "The process of directing proteins towards the nucleus, usually using signals contained within the protein." [GOC:jl]


id: GO:0044747
name: mature miRNA 3'-end processing
namespace: biological_process
def:
  "Any process involved in forming distinct miRNA isoforms from a mature miRNA that differ at their 3'-ends." [PMID:22055292, PMID:22055293]


id: GO:0044748
name: 3'-5'-exoribonuclease activity involved in mature miRNA 3'-end processing
namespace: molecular_function
def:
  "Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of an RNA molecule that contributes to forming distinct miRNA isoforms from a mature miRNA." [GOC:sart]


id: GO:0044749
name: high-affinity zinc II ion transmembrane import
namespace: biological_process
def:
  "The directed, high-affinity movement of zinc (Zn II) ions across a membrane into a cell or organelle. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations." [GOC:jl]


id: GO:0044750
name: high-affinity nickel cation transmembrane transporter activity
namespace: molecular_function
def:
  "Catalysis of the high-affinity transfer of nickel (Ni) cations from one side of a membrane to the other. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations." [GOC:jl]


id: GO:0044751
name: cellular response to human chorionic gonadotropin stimulus
namespace: biological_process
def:
  "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a human chorionic gonadotropin stimulus." [PMID:21325635]


id: GO:0044752
name: response to human chorionic gonadotropin
namespace: biological_process
def:
  "Any process that results in a change in state or activity of a cell or organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a human chorionic gonadotropin stimulus." [PMID:21325635]


id: GO:0044753
name: amphisome
namespace: cellular_component
def:
  "An autophagosome formed upon fusion between autophagosomes and endosomes." [GOC:autophagy, GOC:sart, PMID:19008921, PMID:9705327]


id: GO:0044754
name: autolysosome
namespace: cellular_component
def:
  "A type of secondary lysosome in which a primary lysosome has fused with the outer membrane of an autophagosome. It is involved in the second step of autophagy in which it degrades contents with acidic lysosomal hydrolases." [GOC:sart, NIF_Subcellular:sao8444068431, PMID:19008921]


id: GO:0044755
name: pantothenate import into cell
namespace: biological_process
def:
  "The directed movement of pantothenate from outside of a cell into the cytoplasmic compartment. This may occur via transport across the plasma membrane or via endocytosis." [GOC:jl]


id: GO:0044756
name: biotin import into cell
namespace: biological_process
def:
  "The directed movement of biotin from outside of a cell into the cytoplasmic compartment. This may occur via transport across the plasma membrane or via endocytosis." [GOC:jl]


id: GO:0044757
name: dethiobiotin import into cell
namespace: biological_process
def:
  "The directed movement of dethiobiotin from outside of a cell into the cytoplasmic compartment. This may occur via transport across the plasma membrane or via endocytosis." [GOC:jl]


id: GO:0044758
name: modulation by symbiont of host synaptic transmission
namespace: biological_process
def:
  "Any process in which a symbiont organism modulates the frequency, rate or extent of synaptic transmission, communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse, in its host organism." [GOC:jl]


id: GO:0044760
name: modulation by symbiont of host cholinergic synaptic transmission
namespace: biological_process
def:
  "Any process in which a symbiont organism modulates the frequency, rate or extent of cholinergic synaptic transmission, communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse via the neurotransmitter choline, in its host organism." [GOC:jl]


id: GO:0044761
name: negative regulation by symbiont of host cholinergic synaptic transmission
namespace: biological_process
def:
  "Any process in which a symbiont organism negatively regulates cholinergic synaptic transmission, communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse via the neurotransmitter choline, in its host organism." [GOC:jl]


id: GO:0044762
name: negative regulation by symbiont of host neurotransmitter secretion
namespace: biological_process
def:
  "Any process in which a symbiont organism negatively regulates the regulated release of a neurotransmitter from a cell in its host organism." [GOC:jl]


id: GO:0044763
name: single-organism cellular process
namespace: biological_process
def:
  "Any process that is carried out at the cellular level, occurring within a single organism." [GOC:jl]


id: GO:0044764
name: multi-organism cellular process
namespace: biological_process
def:
  "Any process that is carried out at the cellular level which involves another organism of the same or different species." [GOC:jl]


id: GO:0044765
name: single-organism transport
namespace: biological_process
def:
  "The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore, involving a single organism." [GOC:jl]


id: GO:0044766
name: multi-organism transport
namespace: biological_process
def:
  "The directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore, involving more than one organism." [GOC:jl]


id: GO:0044767
name: single-organism developmental process
namespace: biological_process
def:
  "A biological process whose specific outcome is the progression of an integrated living unit: an anatomical structure (which may be a subcellular structure, cell, tissue, or organ), or organism over time from an initial condition to a later condition, involving only one organism." [GOC:jl]


id: GO:0044768
name: NMS complex assembly involved in kinetochore assembly
namespace: biological_process
def:
  "The formation of a supercomplex by the association of two subcomplexes (known as MIND and Ndc80 in Schizosaccharomyces) that is required for kinetochore assembly." [PMID:22561345]


id: GO:0044769
name: ATPase activity, coupled to transmembrane movement of ions, rotational mechanism
namespace: molecular_function
def:
  "Catalysis of the transfer of ions from one side of a membrane to the other according to the reaction: ATP + H2O + ion(in) = ADP + phosphate + ion(out), by a rotational mechanism." [GOC:jl]


id: GO:0044770
name: cell cycle phase transition
namespace: biological_process
def:
  "The cell cycle process by which a cell commits to entering the next cell cycle phase." [GOC:mtg_cell_cycle]


id: GO:0044771
name: meiotic cell cycle phase transition
namespace: biological_process
def:
  "The cell cycle process by which a cell commits to entering the next meiotic cell cycle phase." [GOC:mtg_cell_cycle]


id: GO:0044772
name: mitotic cell cycle phase transition
namespace: biological_process
def:
  "The cell cycle process by which a cell commits to entering the next mitotic cell cycle phase." [GOC:mtg_cell_cycle]


id: GO:0044773
name: mitotic DNA damage checkpoint
namespace: biological_process
def:
  "A mitotic cell cycle checkpoint that detects and negatively regulates progression through the cell cycle in response to DNA damage." [GOC:mtg_cell_cycle]


id: GO:0044774
name: mitotic DNA integrity checkpoint
namespace: biological_process
def:
  "A mitotic cell cycle process that controls cell cycle progression in response to changes in DNA structure by monitoring the integrity of the DNA. The DNA integrity checkpoint begins with detection of DNA damage, defects in DNA structure or DNA replication, and ends with signal transduction." [GOC:mtg_cell_cycle]


id: GO:0044775
name: DNA polymerase III, beta sliding clamp processivity factor complex
namespace: cellular_component
def:
  "A subcomplex of the DNA polymerase III holoenzyme which is responsible for tethering the catalytic subunit of DNA polymerase to DNA during high-speed replication. The complex is homodimeric in prokaryotes, and homotrimeric in other species." [GOC:jl, UniProt:O73947]


id: GO:0044776
name: DNA polymerase III, core complex
namespace: cellular_component
def:
  "The DNA polymerase III core complex consists of the alpha,epsilon and theta subunits and is carries out the polymerase and the 3'-5' exonuclease proofreading activities." [GOC:jl, UniProt:P06710]


id: GO:0044777
name: single-stranded DNA-binding protein complex
namespace: cellular_component
def:
  "A homotetrameric protein complex that is essential for DNA replication. It supercoils the single-stranded DNA preventing DNA duplexing before the polymerase holoenzyme passes and synthesizes the complementary strand. It is also involved in DNA recombination and repair." [GOC:jl, UniProt:P0AGE0]


id: GO:0044778
name: meiotic DNA integrity checkpoint
namespace: biological_process
def:
  "A meiotic cell cycle process that controls cell cycle progression in response to changes in DNA structure by monitoring the integrity of the DNA. The DNA integrity checkpoint begins with detection of DNA damage, defects in DNA structure or DNA replication, and ends with signal transduction." [GOC:mtg_cell_cycle]


id: GO:0044779
name: meiotic spindle checkpoint
namespace: biological_process
def:
  "A cell cycle checkpoint that delays the metaphase/anaphase transition of a meiotic nuclear division until the spindle is correctly assembled and that the chromosomes are attached to the spindle." [GOC:mtg_cell_cycle]


id: GO:0044780
name: bacterial-type flagellum assembly
namespace: biological_process
def:
  "The assembly of a bacterial-type flagellum, a motor complex composed of an extracellular helical protein filament coupled to a rotary motor embedded in the cell envelope which functions in cell motility." [GOC:jl]


id: GO:0044781
name: bacterial-type flagellum organization
namespace: biological_process
def:
  "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a bacterial-type flagellum, a motor complex composed of an extracellular helical protein filament coupled to a rotary motor embedded in the cell envelope which functions in cell motility." [GOC:jl]


id: GO:0044782
name: cilium organization
namespace: biological_process
def:
  "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a cilium, a specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:jl]


id: GO:0044783
name: G1 DNA damage checkpoint
namespace: biological_process
def:
  "A cell cycle checkpoint that detects and negatively regulates progression from G1 to S phase in the cell cycle in response to DNA damage." [GOC:mtg_cell_cycle]


id: GO:0044784
name: metaphase/anaphase transition of cell cycle
namespace: biological_process
def:
  "The cell cycle process in which a cell progresses from metaphase to anaphase as part of the cell cycle." [GOC:mtg_cell_cycle]


id: GO:0044785
name: metaphase/anaphase transition of meiotic cell cycle
namespace: biological_process
def:
  "The cell cycle process in which a cell progresses from metaphase to anaphase as part of meiosis." [GOC:mtg_cell_cycle]


id: GO:0044786
name: cell cycle DNA replication
namespace: biological_process
def:
  "The DNA-dependent DNA replication that takes place as part of the cell cycle." [GOC:mtg_cell_cycle]


id: GO:0044787
name: bacterial-type DNA replication
namespace: biological_process
def:
  "The DNA-dependent DNA replication, exemplified by prokaryotes, that occurs as part of the cell cycle. Prokaryotic DNA replication is bi-directional and originates at a single origin of replication on the circular genome." [GOC:mtg_cell_cycle]


id: GO:0044788
name: modulation by host of viral process
namespace: biological_process
def:
  "A process in which a host organism modulates the frequency, rate or extent of any of a process being mediated by a virus with which it is infected." [GOC:jl]


id: GO:0044789
name: modulation by host of viral release from host cell
namespace: biological_process
def:
  "A process in which a host organism modulates the frequency, rate or extent of the release of a virus with which it is infected, from its cells." [GOC:jl, PMID:18305167]


id: GO:0044790
name: negative regulation by host of viral release from host cell
namespace: biological_process
def:
  "A process in which a host organism stops, prevents or reduces the frequency, rate or extent of the release of a virus with which it is infected, from its cells." [GOC:jl, PMID:18305167]


id: GO:0044791
name: positive regulation by host of viral release from host cell
namespace: biological_process
def:
  "A process in which a host organism activates or increases the frequency, rate or extent of the release of a virus with which it is infected, from its cells." [GOC:jl]


id: GO:0044793
name: negative regulation by host of viral process
namespace: biological_process
def:
  "A process in which a host organism stops, prevents or reduces the frequency, rate or extent of a process being mediated by a virus with which it is infected." [GOC:jl]


id: GO:0044794
name: positive regulation by host of viral process
namespace: biological_process
def:
  "A process in which a host organism activates or increases the frequency, rate or extent of the release of a process being mediated by a virus with which it is infected." [GOC:jl]


id: GO:0044795
name: trans-Golgi network to recycling endosome transport
namespace: biological_process
def:
  "The directed movement of substances, in membrane-bounded vesicles, from the trans-Golgi network to the recycling endosomes." [GOC:lb, PMID:18779367]


id: GO:0044796
name: DNA polymerase processivity factor complex
namespace: cellular_component
def:
  "A protein complex which is capable of increasing the processivity of nucleotide polymerization by DNA polymerase as a part of DNA replication." [GOC:bhm, GOC:jl]


id: GO:0044797
name: cytoplasmic transcription factor complex
namespace: cellular_component
def:
  "A protein complex, located in the cytoplasm, that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription." [GOC:jl]


id: GO:0044798
name: nuclear transcription factor complex
namespace: cellular_component
def:
  "A protein complex, located in the nucleus, that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription." [GOC:jl]


id: GO:0044799
name: NarGHI complex
namespace: cellular_component
def:
  "A heterotrimeric protein complex with iron-sulfur and molybdenum cofactors that functions as a terminal reductase in electron transport pathways that operate during anaerobic nitrate respiration. In E. coli electrons are passed from the FdnGHI complex to the NarGHI complex via menoquinone and menaquinol. Within NarGHI, electrons are passed from the two heme molecules in the NarI subunit down a Fe-S cluster chain in the NarH and NarG subunits to the Molybdenum cofactor, Mo-bisMGD, in the NarG subunit." [GOC:bhm, PMID:11289299, PMID:12910261, PMID:17964535]


id: GO:0044800
name: multi-organism membrane fusion
namespace: biological_process
def:
  "The membrane organization process that joins two lipid bilayers to form a single membrane, involving more than one organism." [GOC:jl]


id: GO:0044801
name: single-organism membrane fusion
namespace: biological_process
def:
  "The membrane organization process that joins two lipid bilayers to form a single membrane, involving only one organism." [GOC:jl]


id: GO:0044802
name: single-organism membrane organization
namespace: biological_process
def:
  "A process which results in the assembly, arrangement of constituent parts, or disassembly of a membrane, involving only one organism." [GOC:jl]


id: GO:0044803
name: multi-organism membrane organization
namespace: biological_process
def:
  "A process which results in the assembly, arrangement of constituent parts, or disassembly of a membrane, involving more than one organism." [GOC:jl]


id: GO:0044804
name: nucleophagy
namespace: biological_process
def:
  "A selective form of autophagy, by which damaged or non-essential parts of the nucleus, or even an entire nucleus is degraded." [GOC:autophagy, GOC:jl, PMID:24013549]


id: GO:0044805
name: late nucleophagy
namespace: biological_process
def:
  "A type of nucleophagy, distinct from piecemeal microautophagy of the nucleus (PNM) where the nuclear material is delivered to the vacuole/lysosome for breakdown and recycling later than observed for PNM." [GOC:dgf, GOC:jl, PMID:22768199]


id: GO:0044806
name: G-quadruplex DNA unwinding
namespace: biological_process
def:
  "The process by which G-quadruplex (also known as G4) DNA, which is a four-stranded DNA structure held together by guanine base pairing, is unwound or 'melted'." [GOC:jl, GOC:se, PMID:23657261]


id: GO:0044807
name: macrophage migration inhibitory factor production
namespace: biological_process
def:
  "The appearance of macrophage migration inhibitory factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:rv]


id: GO:0044808
name: Oncostatin M production
namespace: biological_process
def:
  "The appearance of Oncostatin M due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:rv]


id: GO:0044809
name: chemokine (C-C motif) ligand 17 production
namespace: biological_process
def:
  "The appearance of chemokine (C-C motif) ligand 17 (CCL17) due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:rv]


id: GO:0044810
name: Dma1-dependent checkpoint
namespace: biological_process
def:
  "Mitotic cell cycle spindle checkpoint that negatively regulates cytokinesis and mitotic exit when the spindle does not form." [GOC:mtg_cell_cycle]


id: GO:0044811
name: response to Dma1-dependent checkpoint signaling
namespace: biological_process
def:
  "A process that occurs in response to signals generated as a result of Dma1-dependent checkpoint signalling." [GOC:mtg_cell_cycle]


id: GO:0044813
name: glycolytic fermentation via PFOR pathway
namespace: biological_process
def:
  "The glycolytic fermentation beginning with the anaerobic conversion of glucose to pyruvate by the glycolytic pathway, continuing with pyruvate:ferredoxin oxidoreductase (PFOR) activity. This pathway is found in strict anaerobes such as Clostridia species." [GOC:mengo_curators, PMID:20395274, PMID:20692761]


id: GO:0044814
name: glycolytic fermentation via PFL pathway
namespace: biological_process
def:
  "The glycolytic fermentation beginning with the anaerobic conversion of glucose to pyruvate by the glycolytic pathway, followed by pyruvate:formate lyase (PFL) activity. This pathway is found in facultative anaerobes such as E. coli." [GOC:mengo_curators, PMID:20395274, PMID:20692761]


id: GO:0044816
name: Nsk1-Dlc1 complex
namespace: cellular_component
def:
  "A dimer of Nsk1 (nucleolus spindle kinetochore 1) and the dynein light chain, Dlc1. The dimers form an oligomeric chain structure. Functions in the regulation of kinetochore-microtubule interactions and chromosome segregation." [GOC:vw, PMID:22065639]


id: GO:0044817
name: hydrogen generation via biophotolysis
namespace: biological_process
def:
  "The production of hydrogen which results from the dissociation by light of water into molecular hydrogen and oxygen. This process is observed in cyanobacteria and microalgae." [GOC:mengo_curators, PMID:20395274, PMID:20692761]


id: GO:0044818
name: mitotic G2/M transition checkpoint
namespace: biological_process
def:
  "A cell cycle checkpoint that detects and negatively regulates progression from G2 to M phase as part of a mitotic cell cycle." [GOC:mtg_cell_cycle]


id: GO:0044819
name: mitotic G1/S transition checkpoint
namespace: biological_process
def:
  "A cell cycle checkpoint that detects and negatively regulates progression from G1 to S phase as part of a mitotic cell cycle." [GOC:mtg_cell_cycle]


id: GO:0044820
name: mitotic telomere tethering at nuclear periphery
namespace: biological_process
def:
  "The process in which a telomere is maintained in a specific location at the nuclear periphery, as part of a mitotic cell cycle." [GOC:mtg_cell_cycle]


id: GO:0044821
name: meiotic telomere tethering at nuclear periphery
namespace: biological_process
def:
  "The process in which a telomere is maintained in a specific location at the nuclear periphery, as part of a meiotic cell cycle." [GOC:mtg_cell_cycle]


id: GO:0044822
name: poly(A) RNA binding
namespace: molecular_function
def:
  "Interacting non-covalently with a poly(A) RNA, a RNA molecule which has a tail of adenine bases." [GOC:jl]


id: GO:0044823
name: retroviral integrase activity
namespace: molecular_function
def:
  "Catalysis of the covalent insertion of double-stranded retroviral DNA into host DNA. Proceeds by an endonucleolytic cleavage at each 3'-OH extremity of the viral genome, named 3'-processing, followed by a strand transfer reaction leading to the insertion of the processed viral DNA into the target DNA by a trans-esterification mechanism." [PMID:19091057]


id: GO:0044824
name: retroviral 3' processing activity
namespace: molecular_function
def:
  "The catalysis of the removal of two di- or tri-nucleotides from each 3' end of double-stranded viral DNA, exposing recessed 3' hydroxyls." [PMID:22580823, Reactome:REACT_9069.1]


id: GO:0044825
name: retroviral strand transfer activity
namespace: molecular_function
def:
  "Catalysis of the covalent insertion of processed 3'-viral DNA ends into host chromosomal DNA by a trans-esterification reaction." [PMID:22580823]


id: GO:0044826
name: viral genome integration into host DNA
namespace: biological_process
def:
  "The insertion into a host genome of viral DNA, usually by the action of an integrase enzyme. Once integrated, the provirus persists in the host cell and serves as a template for the transcription of viral genes and replication of the viral genome, leading to the production of new viruses." [PMID:19091057]


id: GO:0044827
name: modulation by host of viral genome replication
namespace: biological_process
def:
  "A process in which a host organism modulates the frequency, rate or extent of viral genome replication." [GOC:jl]


id: GO:0044828
name: negative regulation by host of viral genome replication
namespace: biological_process
def:
  "A process in which a host organism stops, prevents or reduces the frequency, rate or extent of viral genome replication." [GOC:jl]


id: GO:0044829
name: positive regulation by host of viral genome replication
namespace: biological_process
def:
  "A process in which a host organism activates or increases the frequency, rate or extent of  viral genome replication." [GOC:jl]


id: GO:0044830
name: modulation by host of viral RNA genome replication
namespace: biological_process
def:
  "A process in which a host organism modulates the frequency, rate or extent of viral RNA genome replication." [GOC:jl]


id: GO:0044831
name: modulation by virus of host cytokine production
namespace: biological_process
def:
  "Any process in which a virus modulates the frequency, rate or extent of cytokine production in its host organism." [GOC:jl]


id: GO:0044832
name: positive regulation by virus of host cytokine production
namespace: biological_process
def:
  "The process in which a virus increases the frequency, rate or extent of cytokine production in its host organism." [GOC:jl]


id: GO:0044833
name: modulation by virus of host protein transport
namespace: biological_process
def:
  "Any viral process that modulates the frequency, rate or extent of protein transport in its host organism." [GOC:jl, PMID:22334672]


id: GO:0044834
name: retroviral intasome
namespace: cellular_component
def:
  "A tetramer of retroviral integrase subunits tightly associated with a pair of viral DNA ends. Functions to insert viral DNA into a host cell chromosome." [PMID:20118915]


id: GO:0044835
name: hydrogen generation via nitrogenase
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of H2 (dihydrogen) which involve a nitrogenase activity as one of the steps. This process is observed in cyanobacteria." [GOC:mengo_curators, PMID:22128188]


id: GO:0044836
name: D-xylose fermentation
namespace: biological_process
def:
  "The anaerobic enzymatic conversion of D-xylose to ethanol, yielding energy in the form of ATP." [GOC:mengo_curators]


id: GO:0044837
name: actomyosin contractile ring organization
namespace: biological_process
def:
  "A process which results in the assembly, arrangement of constituent parts, or disassembly of an actomyosin contractile ring." [GOC:mtg_cell_cycle]


id: GO:0044838
name: cell quiescence
namespace: biological_process
def:
  "A specialized resting state that cells enter in response to cues from the cell's environment. Quiescence is characterized by the absence of cell growth and division, by a reprogramming of global gene expression, and by changes characteristic of the organism and specific cell type. Depending on external conditions, quiescence may persist until cell death or cells may resume cell growth and division. In some cell types or under certain conditions, cellular metabolism may proceed." [GOC:jb, GOC:mah]


id: GO:0044839
name: cell cycle G2/M phase transition
namespace: biological_process
def:
  "The cell cycle process by which a cell in G2 phase commits to M phase." [GOC:jl, GOC:mtg_cell_cycle]


id: GO:0044840
name: gut granule
namespace: cellular_component
def:
  "A lysosome-related organelle contained within the intestinal cells of the nematode C. elegans. Gut granules are acidified, birefringent, autofluorescent, and contain the vacuolar H+-ATPase. They also serve as sites of cellular zinc storage." [GOC:kmv, PMID:22916203, PMID:24204312]


id: GO:0044841
name: gut granule membrane
namespace: cellular_component
def:
  "The lumen of a gut granule, a lysosome-related organelle contained within the intestinal cells of the nematode C. elegans." [GOC:kmv, PMID:22916203, PMID:24204312]


id: GO:0044844
name: meiotic interphase II
namespace: biological_process
def:
  "The cell cycle phase which begins at the end of meiosis I cytokinesis and ends when meiosis II prophase begins. During meiotic interphase II no DNA replication takes place, but the centrioles duplicate and spindle fibres emerge." [GOC:jl, GOC:mtg_cell_cycle]


id: GO:0044845
name: chain elongation of O-linked mannose residue
namespace: biological_process
def:
  "Extension of the O-linked mannose residue of a mannoprotein by the stepwise addition of further mannose molecules." [GOC:jl, PMID:19429925]


id: GO:0044846
name: negative regulation by symbiont of indole acetic acid levels in host
namespace: biological_process
def:
  "Any process in which an organism reduces the indole acetic acid levels in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:ml, PMID:18056646]


id: GO:0044847
name: iron acquisition by symbiont from host
namespace: biological_process
def:
  "The process by which a symbiont acquires iron from its host, either from heme or other iron containing molecules such as transferrin and lactoferrin. Begins with either the secretion of symbiont gene products that bind iron- or heme-containing molecules (siderophores and hemophores) from the symbiont cell into the host, or by expression of receptors that bind iron- or heme-containing molecules on the symbiont cell surface. Ends when the iron-containing compound is transported into the symbiont cell." [PMID:15487950, PMID:22865843]


id: GO:0044849
name: estrous cycle
namespace: biological_process
def:
  "A type of ovulation cycle, which occurs in most mammalian therian females, where the endometrium is resorbed if pregnancy does not occur." [GOC:jl, Wikipedia:Estrous_cycle]


id: GO:0044851
name: hair cycle phase
namespace: biological_process
def:
  "The cyclical periods of growth (anagen), regression (catagen), quiescence (telogen), and shedding (exogen) in the life of a hair; one of the collection or mass of filaments growing from the skin of an animal, and forming a covering for a part of the head or for any part or the whole of the body." [GOC:jl]


id: GO:0044852
name: nonrepetitive DNA condensation
namespace: biological_process
def:
  "The process in which chromatin structure of nonrepetitive regions of DNA is compacted prior to and during mitosis in eukaryotic cells." [GOC:jl, PMID:10811823]


id: GO:0044854
name: plasma membrane raft assembly
namespace: biological_process
def:
  "The aggregation, arrangement and bonding together of a set of components to form a plasma membrane raft." [GOC:jl]


id: GO:0044855
name: plasma membrane raft distribution
namespace: biological_process
def:
  "The process that establishes the spatial arrangement of membrane rafts within a plasma membrane." [GOC:jl]


id: GO:0044856
name: plasma membrane raft localization
namespace: biological_process
def:
  "Any process in which plasma membrane rafts are transported to, or maintained in, a specific location." [GOC:jl]


id: GO:0044857
name: plasma membrane raft organization
namespace: biological_process
def:
  "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of plasma membrane rafts." [GOC:jl]


id: GO:0044858
name: plasma membrane raft polarization
namespace: biological_process
def:
  "The clustering and aggregation of plasma membrane rafts at a single cellular pole during activation of particular cell types, such as lymphocytes." [GOC:jl]


id: GO:0044860
name: protein localization to plasma membrane raft
namespace: biological_process
def:
  "A process in which a protein is transported to, or maintained in, a location within a plasma membrane raft." [GOC:jl]


id: GO:0044863
name: modulation by virus of host cell division
namespace: biological_process
def:
  "Any process where an infecting virus modulates the frequency, rate or extent of the physical partitioning and separation of its host's cell into daughter cells." [GOC:jl]


id: GO:0044864
name: positive regulation by virus of host cell division
namespace: biological_process
def:
  "Any process where an infecting virus activates or increases the frequency, rate or extent of its host's cell division." [GOC:jl]


id: GO:0044865
name: negative regulation by virus of host cell division
namespace: biological_process
def:
  "Any process where an infecting virus stops, prevents, or reduces the frequency, rate or extent of its host's cell division." [GOC:jl]


id: GO:0044866
name: modulation by host of viral exo-alpha-sialidase activity
namespace: biological_process
def:
  "The process in which an organism effects a change in symbiont exo-alpha-sialidase activity, the catalysis of the hydrolysis of peptide bonds in a protein." [GOC:jl]


id: GO:0044867
name: modulation by host of viral catalytic activity
namespace: biological_process
def:
  "The process in which a host organism effects a change in the enzyme activity of a virus with which it is infected." [GOC:jl]


id: GO:0044868
name: modulation by host of viral molecular function
namespace: biological_process
def:
  "A process in which a host organism modulates the frequency, rate or extent of any molecular function being mediated by a virus with which it is infected." [GOC:jl]


id: GO:0044870
name: modulation by host of viral glycoprotein metabolic process
namespace: biological_process
def:
  "A process in which a host organism modulates the frequency, rate or extent of viral glycoprotein metabolic process." [GOC:jl]


id: GO:0044871
name: negative regulation by host of viral glycoprotein metabolic process
namespace: biological_process
def:
  "A process in which a host organism stops, prevents or reduces the frequency, rate or extent of viral glycoprotein metabolic process." [GOC:jl]


id: GO:0044872
name: lipoprotein localization
namespace: biological_process
def:
  "Any process in which a lipoprotein is transported to, or maintained in, a specific location." [GOC:jl]


id: GO:0044873
name: lipoprotein localization to membrane
namespace: biological_process
def:
  "A process in which a lipoprotein is transported to, or maintained in, a specific location in a membrane." [GOC:jl]


id: GO:0044874
name: lipoprotein localization to outer membrane
namespace: biological_process
def:
  "A process in which a lipoprotein is transported to, or maintained in, a specific location in an outer membrane." [GOC:jl]


id: GO:0044875
name: gamma-glutamyl hercynylcysteine sulfoxide synthase
namespace: molecular_function
def:
  "Catalysis of the reaction: gamma-glutamyl cysteine + hercynine + O2 <=> gamma-glutamyl-hercynyl cysteine sulfoxide + H2O." [GOC:jl, PMID:24828577]


id: GO:0044876
name: hercynylselenocysteine synthase
namespace: molecular_function
def:
  "Catalysis of the reaction: 2 L-selenocysteine + 2 hercynine + O2 <=> 2 H2O + 2 hercynylselenocysteine." [GOC:jl, PMID:24828577]


id: GO:0044878
name: cytokinesis checkpoint
namespace: biological_process
def:
  "A mitotic cell cycle checkpoint that detects a defect in cytokinesis and negatively regulates mitosis in the following cell cycle." [GOC:jl, GOC:mtg_cell_cycle]


id: GO:0044879
name: morphogenesis checkpoint
namespace: biological_process
def:
  "A mitotic cell cycle checkpoint which delays mitotic onset in response to perturbations that affect cell shape via the actin cytoskeleton, septin organization, small cell size, and/or the extent of membrane growth." [GOC:jl, GOC:mtg_cell_cycle]


id: GO:0045002
name: double-strand break repair via single-strand annealing
namespace: biological_process
def:
  "Repair of a DSB made between two repeated sequences oriented in the same direction occurs primarily by the single strand annealing pathway. The ends of the break are processed by a 5' to 3' exonuclease, exposing complementary single-strand regions of the direct repeats that can anneal, resulting in a deletion of the unique DNA between the direct repeats." [PMID:11606529]


id: GO:0045003
name: double-strand break repair via synthesis-dependent strand annealing
namespace: biological_process
def:
  "SDSA is a major mechanism of double-strand break repair in mitosis which allows for the error-free repair of a double-strand break without the exchange of adjacent sequences. The broken DNA searches for and base pairs with a homologous region in an intact chromosome. DNA synthesis initiates from the 3' end of the invading DNA strand, using the intact chromosome as the template. Newly synthesized DNA is then displaced from the template and anneal with its complement on the other side of the double-strand break." [PMID:10357855]


id: GO:0045005
name: DNA-dependent DNA replication maintenance of fidelity
namespace: biological_process
def:
  "A DNA metabolic process that prevents or corrects errors to ensure that DNA is replicated accurately. Errors can be corrected either by intrinsic DNA polymerase proofreading activity or via mismatch repair." [GOC:mah, GOC:vw]


id: GO:0045006
name: DNA deamination
namespace: biological_process
def:
  "The removal of an amino group from a nucleotide base in DNA. An example is the deamination of cytosine to produce uracil." [GOC:ai]


id: GO:0045007
name: depurination
namespace: biological_process
def:
  "The disruption of the bond between the sugar in the backbone and the A or G base, causing the base to be removed and leaving a depurinated sugar." [GOC:ai]


id: GO:0045008
name: depyrimidination
namespace: biological_process
def:
  "The disruption of the bond between the sugar in the backbone and the C or T base, causing the base to be removed and leaving a depyrimidinated sugar." [GOC:ai]


id: GO:0045009
name: chitosome
namespace: cellular_component
def:
  "An intracellular membrane-bounded particle found in fungi and containing chitin synthase; it synthesizes chitin microfibrils. Chitin synthase activity exists in chitosomes and they are proposed to act as a reservoir for regulated transport of chitin synthase enzymes to the division septum." [ISBN:0198506732, PMID:8970154]


id: GO:0045010
name: actin nucleation
namespace: biological_process
def:
  "The initial step in the formation of an actin filament, in which actin monomers combine to form a new filament. Nucleation is slow relative to the subsequent addition of more monomers to extend the filament." [ISBN:0815316194]


id: GO:0045012
name: obsolete MHC class II receptor activity
namespace: molecular_function
def:
  "OBSOLETE. A major histocompatibility complex class II receptor. These display processed antigens from virally-infected or transformed cells. Class-II-positive cells ('antigen-presenting cells') can take up antigens from outside by endocytosis, degrade them into small peptides, and re-export the peptides (now bound to MHC class II protein) to the cell surface. These peptide-MHC class II complexes can then be recognized by specific CD4+ lymphocytes." [ISBN:081533642X, ISBN:0879694971]


id: GO:0045013
name: carbon catabolite repression of transcription
namespace: biological_process
def:
  "A transcription regulation process in which the presence of one carbon source leads to a decrease in the frequency, rate, or extent of transcription of specific genes involved in the metabolism of other carbon sources. Carbon catabolite repression is a mechanism of genetic regulation which the accumulation of catabolites of one substance in the cell represses the formation of enzymes that contribute to the catabolism of other substances." [GOC:mah, ISBN:0198506732, PMID:11018147, PMID:18359269, PMID:9618445]


id: GO:0045014
name: negative regulation of transcription by glucose
namespace: biological_process
def:
  "Any process involving glucose that stops, prevents or reduces the rate of transcription. The presence of glucose in the growth medium inhibits the synthesis of certain enzymes in bacteria growing on the medium. For example, transcription of some catabolic operons is under negative control by specific repressors and glucose is an anti-inducer of xylose utilization and glycerol kinase." [ISBN:0198506732, PMID:11018147]


id: GO:0045015
name: HDEL sequence binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with a HDEL sequence, the C terminus tetrapeptide sequence His-Asp-Glu-Leu found in proteins that are to be retained in the endoplasmic reticulum." [PMID:1327759]


id: GO:0045016
name: mitochondrial magnesium ion transport
namespace: biological_process
def:
  "The transport of magnesium ions (Mg2+) into, out of or within a mitochondrion. Transport across the mitochondrial membranes is mediated by a mitochondrial inner membrane protein." [GOC:ai, PMID:11254124]


id: GO:0045017
name: glycerolipid biosynthetic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of glycerolipids, any lipid with a glycerol backbone." [GOC:ai]


id: GO:0045018
name: retrograde transport, vacuole to Golgi
namespace: biological_process
def:
  "The directed movement of substances from the vacuole to the trans-Golgi network; this occurs in yeast via the prevacuolar/endosomal compartment." [PMID:9700156]


id: GO:0045019
name: negative regulation of nitric oxide biosynthetic process
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of nitric oxide." [GOC:go_curators]


id: GO:0045020
name: obsolete error-prone DNA repair
namespace: biological_process
def:
  "OBSOLETE. DNA repair pathways that tend to increase the endogenous mutation rate." [GOC:jl, PMID:11459974]


id: GO:0045021
name: obsolete error-free DNA repair
namespace: biological_process
def:
  "OBSOLETE. DNA repair pathways that do not increase the mutation rate above spontaneous background levels, e.g. excision and recombination pathways." [GOC:jl, PMID:11459974]


id: GO:0045022
name: early endosome to late endosome transport
namespace: biological_process
def:
  "The directed movement of substances, in membrane-bounded vesicles, from the early sorting endosomes to the late sorting endosomes; transport occurs along microtubules and can be experimentally blocked with microtubule-depolymerizing drugs." [ISBN:0815316194]


id: GO:0045023
name: G0 to G1 transition
namespace: biological_process
def:
  "The mitotic cell cycle phase transition whose occurrence commits the cell from the G0 quiescent state to the G1 phase. Under certain conditions, cells exit the cell cycle during G1 and remain in the G0 state as nongrowing, non-dividing (quiescent) cells. Appropriate stimulation of such cells induces them to return to G1 and resume growth and division. The G0 to G1 transition is accompanied by many changes in the program of gene expression." [GOC:mtg_cell_cycle, ISBN:0716731363]


id: GO:0045024
name: obsolete peptidyl-glutamyl peptide hydrolyzing enzyme activity
namespace: molecular_function
def:
  "OBSOLETE. Catalysis of the cleavage of bonds after acidic amino acids and after branched chain amino acids." [PMID:11735414]


id: GO:0045025
name: mitochondrial degradosome
namespace: cellular_component
def:
  "A mitochondrial protein complex with 3' to 5' exoribonuclease activity that participates in intron-independent turnover and processing of mitochondrial transcripts. In humans, the mitochondrial degradosome is a pentameric complex, and in yeast it exists as a heterodimer." [PMID:10397341, PMID:9829834]


id: GO:0045026
name: plasma membrane fusion
namespace: biological_process
def:
  "The joining of two or more lipid bilayer membranes that surround a cell." [GOC:elh, GOC:mtg_muscle]


id: GO:0045027
name: DNA end binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with the ends of DNA that are exposed by the creation of double-strand breaks (DSBs)." [GOC:jl]


id: GO:0045028
name: G-protein coupled purinergic nucleotide receptor activity
namespace: molecular_function
def:
  "Combining with a purine nucleotide and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:mah, PMID:9755289]


id: GO:0045029
name: UDP-activated nucleotide receptor activity
namespace: molecular_function
def:
  "Combining with a nucleotide and transmitting the signal to a heterotrimeric G-protein complex to initiate a change in cell activity, activated by UDP." [GOC:mah]


id: GO:0045030
name: UTP-activated nucleotide receptor activity
namespace: molecular_function
def:
  "Combining with a nucleotide and transmitting the signal to a heterotrimeric G-protein complex to initiate a change in cell activity, activated by UTP." [GOC:mah]


id: GO:0045031
name: ATP-activated adenosine receptor activity
namespace: molecular_function
def:
  "Combining with adenosine and transmitting the signal to a heterotrimeric G-protein complex to initiate a change in cell activity, activated by ATP." [GOC:mah]


id: GO:0045032
name: ADP-activated adenosine receptor activity
namespace: molecular_function
def:
  "Combining with adenosine and transmitting the signal to a heterotrimeric G-protein complex to initiate a change in cell activity, activated by ADP." [GOC:mah]


id: GO:0045033
name: peroxisome inheritance
namespace: biological_process
def:
  "The acquisition of peroxisomes by daughter cells from the mother cell after replication. In Saccharomyces cerevisiae, the number of peroxisomes cells is fairly constant; a subset of the organelles are targeted and segregated to the bud in a highly ordered, vectorial process. Efficient segregation of peroxisomes from mother to bud is dependent on the actin cytoskeleton, and active movement of peroxisomes along actin filaments is driven by the class V myosin motor protein, Myo2p." [PMID:11733545]


id: GO:0045034
name: obsolete neuroblast division
namespace: biological_process
def:
  "OBSOLETE. The asymmetrical division of a neuroblast, the neural precursor in the central nervous system, giving rise to another neuroblast and a ganglion mother cell." [PMID:11163136, PMID:11250167]


id: GO:0045035
name: sensory organ precursor cell division
namespace: biological_process
def:
  "The series of four asymmetric divisions undergone by the sensory organ precursor cells to generate cells that have distinct cell fates. For example, in the external sensory organ, the precursor cells give rise to one multidendritic neuron and four additional cells (the socket, shaft, sheath cells and the external sense neuron)." [GOC:mah, PMID:11171389, PMID:18295597]


id: GO:0045036
name: protein targeting to chloroplast
namespace: biological_process
def:
  "The process of directing proteins towards the chloroplast, usually using signals contained within the protein. Imported proteins are synthesized as cytosolic precursors containing N-terminal uptake-targeting sequences that direct each protein to its correct subcompartment and are subsequently cleaved." [ISBN:0716731363]


id: GO:0045037
name: protein import into chloroplast stroma
namespace: biological_process
def:
  "The targeting and import of proteins into the chloroplast stroma. Import depends on ATP hydrolysis catalyzed by stromal chaperones. Chloroplast stromal proteins, such as the S subunit of rubisco, have a N-terminal stromal-import sequence of about 44 amino acids which is cleaved from the protein precursor after import." [ISBN:0716731363]


id: GO:0045038
name: protein import into chloroplast thylakoid membrane
namespace: biological_process
def:
  "The import of proteins into the chloroplast thylakoid membranes. Proteins that are destined for the thylakoid lumen require two uptake-targeting sequences: the first targets the protein to the stroma, and the second targets the protein from the stroma to the thylakoid lumen. Four separate thylakoid-import systems deal with the proteins once they are in the stroma." [ISBN:0716731363]


id: GO:0045039
name: protein import into mitochondrial inner membrane
namespace: biological_process
def:
  "The process comprising the import of proteins into the mitochondrion from outside the organelle and their insertion into the mitochondrial inner membrane. The translocase of the outer membrane complex mediates the passage of these proteins across the outer membrane, after which they are guided by either of two inner membrane translocase complexes into their final destination in the inner membrane." [GOC:mcc, GOC:vw, PMID:18672008]


id: GO:0045040
name: protein import into mitochondrial outer membrane
namespace: biological_process
def:
  "The process comprising the insertion of proteins from outside the organelle into the mitochondrial outer membrane, mediated by large outer membrane translocase complexes." [GOC:mcc, GOC:vw, PMID:18672008]


id: GO:0045041
name: protein import into mitochondrial intermembrane space
namespace: biological_process
def:
  "The import of proteins into the space between the inner and outer mitochondrial membranes." [ISBN:0716731363]


id: GO:0045042
name: obsolete protein import into mitochondrial intermembrane space, conservative
namespace: biological_process
def:
  "OBSOLETE. The conservative import of proteins into the mitochondrial intermembrane space. The entire protein enters the matrix, and then the second targeting sequence directs the protein, presumably bound to a matrix protein, across the inner membrane to the intermembrane space." [ISBN:0716731363]


id: GO:0045045
name: obsolete secretory pathway
namespace: biological_process
def:
  "OBSOLETE. The pathway along which proteins and other substances are moved around and out of the cell. After synthesis on the ribosomes of the endoplasmic reticulum (ER), completed polypeptide chains are moved to the Golgi complex and subsequently sorted to various destinations. Proteins synthesized and sorted in the secretory pathway include not only those that are secreted from the cell but also enzymes and other resident proteins in the lumen of the ER, Golgi, and lysosomes as well as integral proteins in the membranes of these organelles and the plasma membrane." [ISBN:0716731363]


id: GO:0045046
name: protein import into peroxisome membrane
namespace: biological_process
def:
  "The targeting of proteins into the peroxisomal membrane. The process is not well understood, but both signals and mechanism differ from those involved in peroxisomal matrix protein import." [ISBN:0716731363, PMID:11687502]


id: GO:0045047
name: protein targeting to ER
namespace: biological_process
def:
  "The process of directing proteins towards the endoplasmic reticulum (ER) using signals contained within the protein. One common mechanism uses a 16- to 30-residue signal sequence, typically located at the N-terminus of the protein and containing positively charged amino acids followed by a continuous stretch of hydrophobic residues, which directs the ribosome to the ER membrane and initiates transport of the growing polypeptide across the ER membrane." [ISBN:0716731363]


id: GO:0045048
name: protein insertion into ER membrane
namespace: biological_process
def:
  "The process that results in incorporation of a protein into an endoplasmic reticulum (ER) membrane. It depends on specific topogenic sequences of amino acids that ensure that a protein acquires the proper orientation during its insertion into the ER membrane." [ISBN:0716731363]


id: GO:0045049
name: protein insertion into ER membrane by N-terminal cleaved signal sequence
namespace: biological_process
def:
  "A process of protein insertion into the endoplasmic reticulum (ER) membrane in which N-terminal cleaved signal sequences direct polypeptides to the ER." [ISBN:0716731363]


id: GO:0045050
name: protein insertion into ER membrane by stop-transfer membrane-anchor sequence
namespace: biological_process
def:
  "A process of protein insertion into the endoplasmic reticulum (ER) membrane in which stop-transfer membrane-anchor sequences become an ER membrane spanning helix." [ISBN:0716731363]


id: GO:0045051
name: protein insertion into ER membrane by internal uncleaved signal-anchor sequence
namespace: biological_process
def:
  "A process of protein insertion into the endoplasmic reticulum (ER) membrane in which signal anchor sequences function as both ER signal sequences and membrane anchor sequences." [ISBN:0716731363]


id: GO:0045052
name: protein insertion into ER membrane by GPI attachment sequence
namespace: biological_process
def:
  "A process of protein insertion into the endoplasmic reticulum (ER) membrane in which proteins become anchored to the phospholipid bilayer by a covalently attached glycosylphosphatidylinositol (GPI) molecule." [ISBN:0716731363]


id: GO:0045053
name: protein retention in Golgi apparatus
namespace: biological_process
def:
  "The retention of proteins within the Golgi apparatus. Golgi-localized carbohydrate-modifying enzymes have a short N-terminal domain that faces the cytosol, a single transmembrane alpha helix, and a large C-terminal domain that faces the Golgi lumen and that contains the catalytic site. How the membrane-spanning alpha helix in a Golgi enzyme causes its localization and prevents its movement to the plasma membrane is not known." [ISBN:0716731363]


id: GO:0045054
name: constitutive secretory pathway
namespace: biological_process
def:
  "A process of exocytosis found in all eukaryotic cells, in which transport vesicles destined for the plasma membrane leave the trans-Golgi network in a steady stream. Upon exocytosis, the membrane proteins and lipids in these vesicles provide new components for the plasma membrane, and the soluble proteins inside the vesicles are released into the extracellular space." [GOC:mah, ISBN:0716731363]


id: GO:0045055
name: regulated exocytosis
namespace: biological_process
def:
  "A process of exocytosis in which soluble proteins and other substances are initially stored in secretory vesicles for later release. It is found mainly in cells that are specialized for secreting products such as hormones, neurotransmitters, or digestive enzymes rapidly on demand." [GOC:mah, ISBN:0716731363]


id: GO:0045056
name: transcytosis
namespace: biological_process
def:
  "The directed movement of endocytosed material through the cell and its exocytosis from the plasma membrane at the opposite side." [ISBN:0716731363]


id: GO:0045057
name: cisternal progression
namespace: biological_process
def:
  "The process that results in the physical movement of a new cis-Golgi stack from the cis-position, nearest the endoplasmic reticulum (ER), to the trans position, farthest from the ER, successively becoming first a medial-Golgi cisterna and then a trans-Golgi cisterna." [ISBN:0716731363]


id: GO:0045058
name: T cell selection
namespace: biological_process
def:
  "The process in which T cells that express T cell receptors that are restricted by self MHC protein complexes and tolerant to self antigens are selected for further maturation." [ISBN:0781735149, PMID:12414722]


id: GO:0045059
name: positive thymic T cell selection
namespace: biological_process
def:
  "The process of sparing immature T cells in the thymus which react with self-MHC protein complexes with low affinity levels from apoptotic death." [ISBN:0781735149, PMID:12414722]


id: GO:0045060
name: negative thymic T cell selection
namespace: biological_process
def:
  "The process of elimination of immature T cells in the thymus which react strongly with self-antigens." [ISBN:0781735149, PMID:12414722]


id: GO:0045062
name: extrathymic T cell selection
namespace: biological_process
def:
  "The process of T cell selection that occurs in extrathymic locations, often resulting T cells of distinct specificities from those selected in the thymus." [ISBN:0781735149, PMID:7880383]


id: GO:0045063
name: T-helper 1 cell differentiation
namespace: biological_process
def:
  "The process in which a relatively unspecialized T cell acquires the specialized features of a T-helper 1 (Th1) cell. A Th1 cell is a CD4-positive, alpha-beta T cell that has the phenotype T-bet-positive and produces interferon-gamma." [CL:0000545, GOC:ebc]


id: GO:0045064
name: T-helper 2 cell differentiation
namespace: biological_process
def:
  "The process in which a relatively unspecialized T cell acquires specialized features of a T-helper 2 (Th2) cell. A Th2 cell is a CD4-positive, alpha-beta T cell that has the phenotype GATA-3-positive and produces interleukin-4." [CL:0000546, GOC:ebc]


id: GO:0045065
name: cytotoxic T cell differentiation
namespace: biological_process
def:
  "The process in which a relatively unspecialized T cell acquires specialized features of a cytotoxic T cell." [GOC:ai]


id: GO:0045066
name: regulatory T cell differentiation
namespace: biological_process
def:
  "The process in which a relatively unspecialized T cell acquires specialized features of a regulatory T cell. Regulatory T cells control or suppress immune responses through a variety of mechanisms and subsets include the CD4+CD25+ cell type as well as certain CD8+ cell types." [ISBN:0781735149]


id: GO:0045067
name: positive extrathymic T cell selection
namespace: biological_process
def:
  "The process of sparing extrathymically maturing T cells which react with self-MHC protein complexes with low affinity levels from apoptotic death." [ISBN:0781735149, PMID:7880383]


id: GO:0045068
name: negative extrathymic T cell selection
namespace: biological_process
def:
  "The process of elimination of extrathymically maturing T cells which react strongly with self-antigens." [ISBN:0781735149, PMID:7880383]


id: GO:0045070
name: positive regulation of viral genome replication
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of viral genome replication." [GOC:ai]


id: GO:0045071
name: negative regulation of viral genome replication
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of viral genome replication." [GOC:go_curators]


id: GO:0045072
name: regulation of interferon-gamma biosynthetic process
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interferon-gamma." [GOC:go_curators]


id: GO:0045073
name: regulation of chemokine biosynthetic process
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of chemokines." [GOC:go_curators]


id: GO:0045074
name: regulation of interleukin-10 biosynthetic process
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-10." [GOC:go_curators]


id: GO:0045075
name: regulation of interleukin-12 biosynthetic process
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-12." [GOC:go_curators]


id: GO:0045076
name: regulation of interleukin-2 biosynthetic process
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-2." [GOC:go_curators]


id: GO:0045077
name: negative regulation of interferon-gamma biosynthetic process
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interferon-gamma." [GOC:go_curators]


id: GO:0045078
name: positive regulation of interferon-gamma biosynthetic process
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interferon-gamma." [GOC:go_curators]


id: GO:0045079
name: negative regulation of chemokine biosynthetic process
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of chemokines." [GOC:go_curators]


id: GO:0045080
name: positive regulation of chemokine biosynthetic process
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of chemokines." [GOC:go_curators]


id: GO:0045081
name: negative regulation of interleukin-10 biosynthetic process
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-10." [GOC:go_curators]


id: GO:0045082
name: positive regulation of interleukin-10 biosynthetic process
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-10." [GOC:go_curators]


id: GO:0045083
name: negative regulation of interleukin-12 biosynthetic process
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-12." [GOC:go_curators]


id: GO:0045084
name: positive regulation of interleukin-12 biosynthetic process
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-12." [GOC:go_curators]


id: GO:0045085
name: negative regulation of interleukin-2 biosynthetic process
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-2." [GOC:go_curators]


id: GO:0045086
name: positive regulation of interleukin-2 biosynthetic process
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-2." [GOC:go_curators]


id: GO:0045087
name: innate immune response
namespace: biological_process
def:
  "Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens." [GO_REF:0000022, GOC:add, GOC:ebc, GOC:mtg_15nov05, GOC:mtg_sensu]


id: GO:0045088
name: regulation of innate immune response
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of the innate immune response, the organism's first line of defense against infection." [GOC:ebc]


id: GO:0045089
name: positive regulation of innate immune response
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of the innate immune response, the organism's first line of defense against infection." [GOC:ebc]


id: GO:0045091
name: regulation of single stranded viral RNA replication via double stranded DNA intermediate
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of single stranded viral RNA replication via double stranded DNA intermediate." [GOC:go_curators]


id: GO:0045092
name: interleukin-18 receptor complex
namespace: cellular_component
def:
  "A protein complex that binds interleukin-18; comprises an alpha and a beta subunit." [GOC:mah, PMID:12759435]


id: GO:0045093
name: interleukin-18 alpha subunit binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with the alpha subunit of interleukin-18. IL-18a is a component of IL-18 that is essential for IL-18 binding on the surface of T-helper 1 cells." [PMID:10653850]


id: GO:0045094
name: interleukin-18 beta subunit binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with the beta subunit of interleukin-18. IL-18b is a ligand non-binding chain and is required for signaling of IL-18 that binds with IL-18a." [PMID:10653850]


id: GO:0045095
name: keratin filament
namespace: cellular_component
def:
  "A filament composed of acidic and basic keratins (types I and II), typically expressed in epithelial cells. The keratins are the most diverse classes of IF proteins, with a large number of keratin isoforms being expressed. Each type of epithelium always expresses a characteristic combination of type I and type II keratins." [ISBN:0716731363]


id: GO:0045098
name: type III intermediate filament
namespace: cellular_component
def:
  "A type of intermediate filament, typically made up of one or more of the proteins vimentin, desmin, glial fibrillary acidic protein (GFAP), and peripherin. Unlike the keratins, the type III proteins can form both homo- and heteropolymeric IF filaments." [ISBN:0716731363]


id: GO:0045101
name: obsolete glial fibrillary acidic protein
namespace: cellular_component
def:
  "OBSOLETE. Glial fibrillary acidic protein forms filaments in the glial cells that surround neurons and in astrocytes." [ISBN:0716731363]


id: GO:0045102
name: obsolete peripherin
namespace: cellular_component
def:
  "OBSOLETE. Peripherin is a type III intermediate filament protein found in neurons of the peripheral nervous system." [ISBN:0716731363]


id: GO:0045103
name: intermediate filament-based process
namespace: biological_process
def:
  "Any cellular process that depends upon or alters the intermediate filament cytoskeleton, that part of the cytoskeleton comprising intermediate filaments and their associated proteins." [GOC:ai]


id: GO:0045104
name: intermediate filament cytoskeleton organization
namespace: biological_process
def:
  "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising intermediate filaments and their associated proteins." [GOC:ai]


id: GO:0045105
name: intermediate filament polymerization or depolymerization
namespace: biological_process
def:
  "Assembly or disassembly of intermediate filaments by the addition or removal of component parts from a filament." [GOC:ai]


id: GO:0045106
name: intermediate filament depolymerization
namespace: biological_process
def:
  "Disassembly of intermediate filaments by the removal of component monomers from a filament." [GOC:mah, ISBN:0716731363]


id: GO:0045107
name: intermediate filament polymerization
namespace: biological_process
def:
  "Assembly of intermediate filaments by the addition of component monomers to a filament. Polymerization of intermediate filament proteins results from interactions among several distinct binding sites on the constituent proteins. Nuclear lamin head-to-tail polymers arise from one such interaction. Deletion analysis localized the binding sites to the ends of the rod domain that are highly conserved among all intermediate filament proteins. Data indicate that one type of interaction in intermediate filament protein polymerization is the longitudinal binding of dimers via the conserved end segments of the coiled-coil rod domain." [GOC:mah, PMID:8776884]


id: GO:0045108
name: regulation of intermediate filament polymerization or depolymerization
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of the assembly or disassembly of intermediate filaments by the addition or removal of monomers from a filament; this usually occurs through the opposing action of kinases and phosphatases." [ISBN:0716731363]


id: GO:0045109
name: intermediate filament organization
namespace: biological_process
def:
  "Control of the spatial distribution of intermediate filaments; includes organizing filaments into meshworks, bundles, or other structures, as by cross-linking." [GOC:ai]


id: GO:0045110
name: intermediate filament bundle assembly
namespace: biological_process
def:
  "The formation of the bundles of intermediate filaments. Intermediate filament-associated proteins (IFAPs) cross-link intermediate filaments with one another, forming a bundle or a network, and with other cell structures, including the plasma membrane. The organization of intermediate filaments and their supportive function in various cells types depends in large part on their linkage to other cell structures via IFAPs." [ISBN:0716731363]


id: GO:0045111
name: intermediate filament cytoskeleton
namespace: cellular_component
def:
  "Cytoskeletal structure made from intermediate filaments, typically organized in the cytosol as an extended system that stretches from the nuclear envelope to the plasma membrane. Some intermediate filaments run parallel to the cell surface, while others traverse the cytosol; together they form an internal framework that helps support the shape and resilience of the cell." [ISBN:0716731363]


id: GO:0045112
name: integrin biosynthetic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of integrins, a large family of transmembrane proteins that act as receptors for cell-adhesion molecules." [GOC:go_curators, ISBN:0198506732]


id: GO:0045113
name: regulation of integrin biosynthetic process
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of integrins." [GOC:go_curators]


id: GO:0045114
name: beta 2 integrin biosynthetic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of beta 2 integrins, a subfamily of integrins which contain the beta 2 subunit." [GOC:go_curators]


id: GO:0045115
name: regulation of beta 2 integrin biosynthetic process
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of beta 2 integrins." [GOC:go_curators]


id: GO:0045116
name: protein neddylation
namespace: biological_process
def:
  "Covalent attachment of the ubiquitin-like protein NEDD8 (RUB1) to another protein." [PMID:11698580]


id: GO:0045117
name: azole transport
namespace: biological_process
def:
  "The directed movement of azoles, heterocyclic compounds found in many biologically important substances, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:go_curators, ISBN:3527307206, Wikipedia:Azole]


id: GO:0045118
name: azole transporter activity
namespace: molecular_function
def:
  "Enables the directed movement of azoles, heterocyclic compound found in many biologically important substances, into, out of or within a cell, or between cells." [GOC:go_curators, ISBN:3527307206, Wikipedia:Azole]


id: GO:0045119
name: azole:proton antiporter activity
namespace: molecular_function
def:
  "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + azole(in) = H+(in) + azole(out). Azoles are heterocyclic compounds found in many biologically important substances." [GOC:ai, ISBN:3527307206, Wikipedia:Azole]


id: GO:0045120
name: pronucleus
namespace: cellular_component
def:
  "The nucleus of either the ovum or the spermatozoon following fertilization. Thus, in the fertilized ovum, there are two pronuclei, one originating from the ovum, the other from the spermatozoon that brought about fertilization; they approach each other, but do not fuse until just before the first cleavage, when each pronucleus loses its membrane to release its contents." [ISBN:0198506732]


id: GO:0045121
name: membrane raft
namespace: cellular_component
def:
  "Any of the small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes. Small rafts can sometimes be stabilized to form larger platforms through protein-protein and protein-lipid interactions." [PMID:16645198, PMID:20044567]


id: GO:0045122
name: aflatoxin biosynthetic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of aflatoxin, a fungal metabolite found as a contaminant in moldy grains that induces liver cancer. Aflatoxin induces a G to T transversion at codon 249 of p53, leading to its inactivation. Aflatoxin is converted to a chemical carcinogen by P450." [ISBN:0716731363, ISBN:0815316194]


id: GO:0045124
name: regulation of bone resorption
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of bone tissue loss (resorption)." [GOC:ai]


id: GO:0045125
name: bioactive lipid receptor activity
namespace: molecular_function
def:
  "Combining with a bioactive lipid and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. A bioactive lipid is a lipid for which changes in lipid levels result in functional consequences in a variety of cellular processes." [GOC:bf, GOC:mah, PMID:12215548, PMID:18216770]


id: GO:0045127
name: N-acetylglucosamine kinase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: N-acetyl-D-glucosamine + ATP = N-acetyl-D-glucosamine 6-phosphate + ADP + 2 H(+)." [EC:2.7.1.59, RHEA:17420]


id: GO:0045128
name: negative regulation of reciprocal meiotic recombination
namespace: biological_process
def:
  "Any process that decreases the frequency, rate or extent of recombination during meiosis. Reciprocal meiotic recombination is the cell cycle process in which double strand breaks are formed and repaired through a double Holliday junction intermediate." [GOC:ai, GOC:dph, GOC:tb]


id: GO:0045129
name: NAD-independent histone deacetylase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: histone N6-acetyl-L-lysine + H2O = histone L-lysine + acetate. This reaction does not require the presence of NAD, and represents the removal of an acetyl group from a histone." [EC:3.5.1.17, RHEA:24551]


id: GO:0045130
name: keratan sulfotransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + keratan = adenosine 3',5'-bisphosphate + keratan 6'-sulfate." [EC:2.8.2.21]


id: GO:0045131
name: pre-mRNA branch point binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with a pre-mRNA branch point sequence, located upstream of the 3' splice site." [PMID:11691992, PMID:9722632]


id: GO:0045132
name: meiotic chromosome segregation
namespace: biological_process
def:
  "The process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets during M phase of the meiotic cell cycle." [GOC:ai, GOC:mah]


id: GO:0045133
name: 2,3-dihydroxybenzoate 3,4-dioxygenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 2,3-dihydroxybenzoate + O(2) = 2-hydroxy-3-(3-oxoprop-1-enyl)but-2-enedioate + H(+)." [EC:1.13.11.14, RHEA:18480]


id: GO:0045135
name: poly(beta-D-mannuronate) lyase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: polysaccharides containing beta-D-mannuronate residues = oligosaccharides with 4-deoxy-alpha-L-erythro-hex-4-enopyranuronosyl end. This reaction is the eliminative cleavage of polysaccharides containing beta-D-mannuronate residues to give oligosaccharides with 4-deoxy-alpha-L-erythro-hex-4-enopyranuronosyl groups at their ends." [EC:4.2.2.3]


id: GO:0045136
name: development of secondary sexual characteristics
namespace: biological_process
def:
  "The process whose specific outcome is the progression of the secondary sexual characteristics over time, from their formation to the mature structures. In humans, these include growth of axillary, chest, and pubic hair, voice changes, testicular/penile enlargement, breast development and menstrual periods. Development occurs in response to sex hormone secretion." [GOC:ai]


id: GO:0045137
name: development of primary sexual characteristics
namespace: biological_process
def:
  "The process whose specific outcome is the progression of the primary sexual characteristics over time, from their formation to the mature structures. The primary sexual characteristics are the testes in males and the ovaries in females and they develop in response to sex hormone secretion." [GOC:ai]


id: GO:0045138
name: nematode male tail tip morphogenesis
namespace: biological_process
def:
  "The process in which the anatomical structure of the adult male tail tip is generated and organized. In some species of rhabitid nematodes, the male tail tip undergoes a morphological change such that the most posterior hypodermal cells in the tail (hyp8-11 in C. elegans) fuse and retract anteriorly, changing the shape of the tail from a pointed, tapered cone, or spike, to a rounded, blunt dome." [GOC:kmv, PMID:16806150, PMID:18050419, PMID:21408209, PMID:7409314]


id: GO:0045140
name: inositol phosphoceramide synthase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: phytoceramide + inositol phosphate = inositol phosphoceramide." [MetaCyc:RXN3O-581, PMID:9405490, PMID:9614099]


id: GO:0045141
name: meiotic telomere clustering
namespace: biological_process
def:
  "The cell cycle process in which the dynamic reorganization of telomeres occurs in early meiotic prophase, during which meiotic chromosome ends are gathered in a bouquet arrangement at the inner surface of the nuclear envelope proximal to the spindle pole body. This plays an important role in progression through meiosis and precedes synapsis." [GOC:vw, PMID:10690419]


id: GO:0045142
name: triplex DNA binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with a DNA triple helix. The formation of triple helical DNA has been evoked in several cellular processes including transcription, replication, and recombination." [PMID:10681538]


id: GO:0045143
name: homologous chromosome segregation
namespace: biological_process
def:
  "The cell cycle process in which replicated homologous chromosomes are organized and then physically separated and apportioned to two sets during the first division of the meiotic cell cycle. Each replicated chromosome, composed of two sister chromatids, aligns at the cell equator, paired with its homologous partner; this pairing off, referred to as synapsis, permits genetic recombination. One homolog (both sister chromatids) of each morphologic type goes into each of the resulting chromosome sets." [GOC:ai, ISBN:0815316194]


id: GO:0045144
name: meiotic sister chromatid segregation
namespace: biological_process
def:
  "The cell cycle process in which sister chromatids are organized and then physically separated and randomly apportioned to two sets during the second division of the meiotic cell cycle." [GOC:ai, ISBN:0815316194]


id: GO:0045145
name: single-stranded DNA 5'-3' exodeoxyribonuclease activity
namespace: molecular_function
def:
  "Catalysis of the sequential cleavage of nucleotides (such as mononucleotides or dinucleotides) from a free 5' terminus of a single-stranded DNA molecule." [GOC:ai, GOC:elh, PMID:20086101]


id: GO:0045146
name: initiation of acetate catabolic process by acetate
namespace: biological_process
def:
  "The activation, by acetate, of the chemical reactions and pathways resulting in the breakdown of acetate." [PMID:11741859]


id: GO:0045147
name: regulation of initiation of acetate catabolic process by acetate
namespace: biological_process
def:
  "Any process that modulates the activation, by acetate, of the chemical reactions and pathways resulting in the breakdown of acetate." [GOC:go_curators]


id: GO:0045149
name: acetoin metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving acetoin, 3-hydroxy-2-butanone, often as part of a fermentation pathway or for use as a carbon source." [GOC:mlg]


id: GO:0045150
name: acetoin catabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the breakdown of acetoin, 3-hydroxy-2-butanone." [GOC:mlg]


id: GO:0045151
name: acetoin biosynthetic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of acetoin, 3-hydroxy-2-butanone." [GOC:mlg]


id: GO:0045152
name: antisigma factor binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with an antisigma factor, a factor which inhibits the ability of the sigma factor to function as a transcriptional initiator." [GOC:mlg]


id: GO:0045153
name: electron transporter, transferring electrons within CoQH2-cytochrome c reductase complex activity
namespace: molecular_function
def:
  "Enables the directed movement of electrons within the CoQH2-cytochrome c reductase complex." [GOC:ai, ISBN:0716731363]


id: GO:0045154
name: electron transporter, transferring electrons within cytochrome c oxidase complex activity
namespace: molecular_function
def:
  "Enables the directed movement of electrons within the cytochrome c oxidase complex." [GOC:ai, ISBN:0716731363]


id: GO:0045155
namespace: molecular_function
name:
  electron transporter, transferring electrons from CoQH2-cytochrome c reductase complex and cytochrome c oxidase complex activity

def:
  "Enables the directed movement of electrons from the CoQH2-cytochrome c reductase complex and the cytochrome c oxidase complex." [GOC:ai, ISBN:0716731363]


id: GO:0045156
namespace: molecular_function
name:
  electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity

def:
  "Enables the directed movement of electrons within the cyclic electron transport pathway of photosynthesis." [GOC:ai, ISBN:0716731363]


id: GO:0045157
namespace: molecular_function
name:
  electron transporter, transferring electrons within the noncyclic electron transport pathway of photosynthesis activity

def:
  "Enables the directed movement of electrons within the noncyclic electron transport pathway of photosynthesis." [GOC:ai, ISBN:0716731363]


id: GO:0045158
namespace: molecular_function
name:
  electron transporter, transferring electrons within cytochrome b6/f complex of photosystem II activity

def:
  "Enables the directed movement of electrons within the cytochrome b6/f complex of photosystem II." [GOC:ai, ISBN:0716731363]


id: GO:0045159
name: myosin II binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with a class II myosin, any member of the class of 'conventional' double-headed myosins that includes muscle myosin." [GOC:mah, http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html]


id: GO:0045160
name: myosin I complex
namespace: cellular_component
def:
  "A myosin complex containing a class I myosin heavy chain and associated light chains; myosin I heavy chains are single-headed, possess tails of various lengths, and do not self-associate into bipolar filaments; myosin I complexes are involved in diverse processes related to membrane traffic and cell movement." [GOC:mah, http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html, PMID:9438839]


id: GO:0045161
name: neuronal ion channel clustering
namespace: biological_process
def:
  "The process in which voltage-gated ion channels become localized to distinct subcellular domains in the neuron. Specific targeting, clustering, and maintenance of these channels in their respective domains are essential to achieve high conduction velocities of action potential propagation." [PMID:11456440]


id: GO:0045162
name: clustering of voltage-gated sodium channels
namespace: biological_process
def:
  "The process in which voltage-gated sodium channels become localized together in high densities. In animals, nodes of Ranvier differ dramatically from internodal axonal regions in very high densities of voltage-dependent sodium (Nav) channels responsible for the rapid, inward ionic currents that produce membrane depolarization." [PMID:11456440]


id: GO:0045163
name: clustering of voltage-gated potassium channels
namespace: biological_process
def:
  "The process in which voltage-gated potassium channels become localized together in high densities. In animals, voltage-gated potassium (Kv) channels are clustered beneath the myelin sheath in regions immediately adjacent to paranodes, called juxtaparanodes, and along the inner mesaxon within the internode." [PMID:11456440]


id: GO:0045164
name: obsolete secretin (sensu Mammalia)
namespace: molecular_function
def:
  "OBSOLETE. Secretin is a hormone that takes part in the digestion process. It also has effects on organs other than gastrointestinal tract." [PMID:11320551]


id: GO:0045165
name: cell fate commitment
namespace: biological_process
def:
  "The commitment of cells to specific cell fates and their capacity to differentiate into particular kinds of cells. Positional information is established through protein signals that emanate from a localized source within a cell (the initial one-cell zygote) or within a developmental field." [ISBN:0716731185]


id: GO:0045167
name: asymmetric protein localization involved in cell fate determination
namespace: biological_process
def:
  "Any process in which a protein is transported to, or maintained in, a specific asymmetric distribution, resulting in the formation of daughter cells of different types." [GOC:ai]


id: GO:0045168
name: cell-cell signaling involved in cell fate commitment
namespace: biological_process
def:
  "Signaling at long or short range between cells that results in the commitment of a cell to a certain fate." [GOC:dph, GOC:go_curators, GOC:tb]


id: GO:0045169
name: fusome
namespace: cellular_component
def:
  "A large intracellular spectrin-rich structure that has been found in insect germline cells and mammalian hematopoietic cells. The fusome is an elongated, branched structure, formed from the spherical spectrosome organelle." [GOC:bf, PMID:12655376]


id: GO:0045170
name: spectrosome
namespace: cellular_component
def:
  "A germline specific spherical organelle, rich in membrane skeletal proteins. Precursor to the fusome." [GOC:bf]


id: GO:0045171
name: intercellular bridge
namespace: cellular_component
def:
  "A direct connection between the cytoplasm of two cells that is formed following the completion of cleavage furrow ingression during cell division. They are usually present only briefly prior to completion of cytokinesis. However, in some cases, such as the bridges between germ cells during their development, they become stabilised." [PMID:9635420]


id: GO:0045172
name: germline ring canal
namespace: cellular_component
def:
  "Germline specific intercellular bridge. During cyst formation in insects, ring canals interconnect the cells of the cyst, facilitating the passage of cytoplasmic components between cells." [GOC:mtg_sensu, PMID:9635420, PMID:9655801]


id: GO:0045173
name: O-sialoglycoprotein catabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the breakdown of O-sialoglycoproteins, glycoproteins which contain sialic acid as one of their carbohydrates. They are often found on or in the cell or tissue membranes and participate in a variety of biological activities." [GOC:go_curators, PMID:8824323]


id: GO:0045174
name: glutathione dehydrogenase (ascorbate) activity
namespace: molecular_function
def:
  "Catalysis of the reaction: dehydroascorbate + 2 glutathione = L-ascorbate + glutathione disulfide." [EC:1.8.5.1, RHEA:24427]


id: GO:0045175
name: basal protein localization
namespace: biological_process
def:
  "Any process in which a protein is transported to, or maintained in, basal regions of the cell." [GOC:bf]


id: GO:0045176
name: apical protein localization
namespace: biological_process
def:
  "Any process in which a protein is transported to, or maintained in, apical regions of the cell." [GOC:bf]


id: GO:0045177
name: apical part of cell
namespace: cellular_component
def:
  "The region of a polarized cell that forms a tip or is distal to a base. For example, in a polarized epithelial cell, the apical region has an exposed surface and lies opposite to the basal lamina that separates the epithelium from other tissue." [GOC:mah, ISBN:0815316194]


id: GO:0045178
name: basal part of cell
namespace: cellular_component
def:
  "The region of a cell situated near the base. For example, in a polarized epithelial cell, the basal surface rests on the basal lamina that separates the epithelium from other tissue." [GOC:mah, ISBN:0185316194]


id: GO:0045181
name: glutamate synthase activity, NAD(P)H as acceptor
namespace: molecular_function
def:
  "Catalysis of the reaction: 2 L-glutamate + NAD(P)+ = L-glutamine + 2-oxoglutarate + NAD(P)H + H+." [EC:1.4.1.13, EC:1.4.1.14]


id: GO:0045182
name: translation regulator activity
namespace: molecular_function
def:
  "Any molecular function involved in the initiation, activation, perpetuation, repression or termination of polypeptide synthesis at the ribosome." [GOC:ai]


id: GO:0045183
name: translation factor activity, non-nucleic acid binding
namespace: molecular_function
def:
  "A translation regulator activity that does not involve binding to nucleic acids." [GOC:ai, GOC:dph, GOC:tb]


id: GO:0045185
name: maintenance of protein location
namespace: biological_process
def:
  "Any process in which a protein is maintained in a location and prevented from moving elsewhere. These include sequestration, stabilization to prevent transport elsewhere and the active retrieval of proteins that do move away." [GOC:bf]


id: GO:0045186
name: zonula adherens assembly
namespace: biological_process
def:
  "Assembly of the zonula adherens, a cell-cell adherens junction which forms a continuous belt near the apex of epithelial cells." [GOC:bf]


id: GO:0045187
name: regulation of circadian sleep/wake cycle, sleep
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of sleep; a readily reversible state of reduced awareness and metabolic activity that occurs periodically in many animals." [GOC:jl, ISBN:0192800981]


id: GO:0045188
name: regulation of circadian sleep/wake cycle, non-REM sleep
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of non-rapid eye movement sleep." [GOC:go_curators]


id: GO:0045189
name: connective tissue growth factor biosynthetic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of CTGF, produced by human umbilical vein endothelial cells and by skin fibroblasts after activation with TGF-beta." [http://www.copewithcytokines.de]


id: GO:0045190
name: isotype switching
namespace: biological_process
def:
  "The switching of activated B cells from IgM biosynthesis to biosynthesis of other isotypes of immunoglobulin, accomplished through a recombination process involving an intrachromosomal deletion involving switch regions that reside 5' of each constant region gene segment in the immunoglobulin heavy chain locus." [ISBN:0781735149]


id: GO:0045192
name: obsolete low-density lipoprotein catabolic process
namespace: biological_process
def:
  "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of low-density lipoproteins, also known as beta lipoproteins, one of the classes of lipoproteins found in the bloodstream of animals, acting as a carrier for cholesterol and fats." [GOC:go_curators, ISBN:0198506732]


id: GO:0045193
name: obsolete acetylated low-density lipoprotein catabolic process
namespace: biological_process
def:
  "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of acetylated low-density lipoproteins." [GOC:go_curators]


id: GO:0045194
name: obsolete oxidized low-density lipoprotein catabolic process
namespace: biological_process
def:
  "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of oxidized low-density lipoproteins." [GOC:go_curators]


id: GO:0045195
name: obsolete gallstone formation
namespace: biological_process
def:
  "OBSOLETE. The formation of gallstones, hard, crystal-like accretions of cholesterol and bile pigments which develop when bile contains too much cholesterol and not enough bile." [http://www.ddc.musc.edu/ddc_pro/pro_development/basic_science/gallstones.htm]


id: GO:0045196
name: establishment or maintenance of neuroblast polarity
namespace: biological_process
def:
  "Any cellular process that results in the specification, formation or maintenance of the apicobasal polarity of a neuroblast cell, a progenitor of the central nervous system." [GOC:bf, GOC:mah, GOC:mtg_sensu, PMID:19375318, PMID:20066083]


id: GO:0045197
name: establishment or maintenance of epithelial cell apical/basal polarity
namespace: biological_process
def:
  "Any cellular process that results in the specification, formation or maintenance of the apicobasal polarity of an epithelial cell." [GOC:bf, GOC:mah]


id: GO:0045198
name: establishment of epithelial cell apical/basal polarity
namespace: biological_process
def:
  "The specification and formation of the apicobasal polarity of an epithelial cell." [GOC:ascb_2009, GOC:bf, GOC:dph, GOC:tb]


id: GO:0045200
name: establishment of neuroblast polarity
namespace: biological_process
def:
  "The specification and formation of the apicobasal polarity of a neuroblast cell, a progenitor of the central nervous system." [GOC:bf, GOC:mtg_sensu]


id: GO:0045201
name: maintenance of neuroblast polarity
namespace: biological_process
def:
  "The maintenance of the apicobasal polarity of a neuroblast cell, a progenitor of the central nervous system." [GOC:bf, GOC:mtg_sensu]


id: GO:0045202
name: synapse
namespace: cellular_component
def:
  "The junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell; the site of interneuronal communication. As the nerve fiber approaches the synapse it enlarges into a specialized structure, the presynaptic nerve ending, which contains mitochondria and synaptic vesicles. At the tip of the nerve ending is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic nerve ending secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane." [ISBN:0198506732]


id: GO:0045203
name: integral component of cell outer membrane
namespace: cellular_component
def:
  "The component of the cell outer membrane consisting of the gene products having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators, GOC:mtg_sensu]


id: GO:0045205
name: obsolete MAPK transporter activity
namespace: molecular_function
def:
  "OBSOLETE. Enables the directed movement of MAP kinase into, out of or within a cell, or between cells." [GOC:ebc, GOC:mtg_transport, ISBN:0815340729]


id: GO:0045206
name: obsolete MAPK phosphatase transporter activity
namespace: molecular_function
def:
  "OBSOLETE. Enables the directed movement of MAPK phosphatase into, out of or within a cell, or between cells." [GOC:ebc, GOC:mtg_transport, ISBN:0815340729]


id: GO:0045209
name: MAPK phosphatase export from nucleus, leptomycin B sensitive
namespace: biological_process
def:
  "Leptomycin B-sensitive movement of a MAPK phosphatase from the nucleus to the cytoplasm." [GOC:ebc]


id: GO:0045210
name: FasL biosynthetic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of fas ligand (FasL or CD95L), an antigen originally found to be expressed on the cell surface of activated human T-lymphocytes and B-lymphocytes and a variety of malignant human lymphoid cell lines." [http://www.copewithcytokines.de/]


id: GO:0045211
name: postsynaptic membrane
namespace: cellular_component
def:
  "A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters cross the synaptic cleft and transmit the signal to the postsynaptic membrane." [ISBN:0198506732]


id: GO:0045212
name: neurotransmitter receptor biosynthetic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of neurotransmitter receptors." [GOC:ai]


id: GO:0045214
name: sarcomere organization
namespace: biological_process
def:
  "The myofibril assembly process that results in the organization of muscle actomyosin into sarcomeres. The sarcomere is the repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs." [GOC:bf]


id: GO:0045216
name: cell-cell junction organization
namespace: biological_process
def:
  "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a cell-cell junction. A cell-cell junction is a specialized region of connection between two cells." [GOC:ai, GOC:dph, GOC:jl, GOC:mah]


id: GO:0045218
name: zonula adherens maintenance
namespace: biological_process
def:
  "Maintaining the zonula adherens junction, the cell-cell adherens junction formed near the apex of epithelial cells." [GOC:bf]


id: GO:0045219
name: regulation of FasL biosynthetic process
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of FasL." [GOC:go_curators]


id: GO:0045220
name: positive regulation of FasL biosynthetic process
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of FasL." [GOC:go_curators]


id: GO:0045221
name: negative regulation of FasL biosynthetic process
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of FasL." [GOC:go_curators]


id: GO:0045222
name: CD4 biosynthetic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of CD4, a CD marker that occurs on T-helper cells and is involved in MHC class II restricted interactions." [GOC:go_curators, ISBN:0198506732]


id: GO:0045223
name: regulation of CD4 biosynthetic process
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of CD4." [GOC:go_curators]


id: GO:0045224
name: positive regulation of CD4 biosynthetic process
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of CD4." [GOC:go_curators]


id: GO:0045225
name: negative regulation of CD4 biosynthetic process
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of CD4." [GOC:go_curators]


id: GO:0045226
name: extracellular polysaccharide biosynthetic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of polysaccharides used in extracellular structures." [GOC:ai, GOC:go_curators]


id: GO:0045227
name: capsule polysaccharide biosynthetic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of polysaccharides that make up the capsule, a protective structure surrounding some species of bacteria and fungi." [GOC:go_curators]


id: GO:0045228
name: slime layer polysaccharide biosynthetic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of polysaccharides in the slime layer, a diffused layer of polysaccharide exterior to the bacterial cell wall." [GOC:go_curators]


id: GO:0045229
name: external encapsulating structure organization
namespace: biological_process
def:
  "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of external structures that lie outside the plasma membrane and surround the entire cell." [GOC:ai, GOC:dph, GOC:jl, GOC:mah]


id: GO:0045230
name: capsule organization
namespace: biological_process
def:
  "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the capsule, a protective structure surrounding some species of bacteria and fungi." [GOC:ai]


id: GO:0045231
name: slime layer organization
namespace: biological_process
def:
  "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a slime layer. A slime layer is an easily removed, diffuse, unorganized layer of extracellular material that surrounds a cell." [GOC:ai]


id: GO:0045232
name: S-layer organization
namespace: biological_process
def:
  "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an S-layer enveloping the cell. The S-layer is a crystalline protein layer surrounding some bacteria." [GOC:ai]


id: GO:0045233
name: obsolete natural killer cell receptor activity
namespace: molecular_function
def:
  "OBSOLETE. A receptor found on the surface of natural killer cells which binds Class I MHC antigens and is required for activation of NK activity. It belongs to the Ly49i family." [GOC:ebc]


id: GO:0045236
name: CXCR chemokine receptor binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with a chemokine receptor in the CXCR family." [GOC:ceb, PMID:11910892]


id: GO:0045237
name: CXCR1 chemokine receptor binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with the CXCR1 chemokine receptor." [GOC:ceb, PMID:11910892]


id: GO:0045238
name: CXCR2 chemokine receptor binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with the CXCR2 chemokine receptor." [GOC:ceb, PMID:11910892]


id: GO:0045241
name: cytosolic alpha-ketoglutarate dehydrogenase complex
namespace: cellular_component
def:
  "Cytosolic complex that possesses alpha-ketoglutarate dehydrogenase activity." [GOC:mah, GOC:mtg_sensu]


id: GO:0045243
name: cytosolic isocitrate dehydrogenase complex (NAD+)
namespace: cellular_component
def:
  "Cytosolic complex that possesses isocitrate dehydrogenase (NAD+) activity." [GOC:mah, GOC:mtg_sensu]


id: GO:0045244
name: succinate-CoA ligase complex (GDP-forming)
namespace: cellular_component
def:
  "A heterodimeric enzyme complex, usually composed of an alpha and beta chain. Functions in the TCA cycle, hydrolyzing succinyl-CoA into succinate and CoA, thereby forming GTP." [EC:6.2.1.4, GOC:jl]


id: GO:0045246
name: cytosolic tricarboxylic acid cycle enzyme complex
namespace: cellular_component
def:
  "Any of the heteromeric enzymes, located in the cytosol, that act in the tricarboxylic acid (TCA) cycle." [GOC:mah, GOC:mtg_sensu]


id: GO:0045247
name: cytosolic electron transfer flavoprotein complex
namespace: cellular_component
def:
  "A protein complex located in the cytosol containing flavin adenine dinucleotide (FAD) that, together with an acyl-CoA dehydrogenase, forms a system that oxidizes an acyl-CoA molecule and reduces ubiquinone and other acceptors." [GOC:mtg_sensu, ISBN:0198506732]


id: GO:0045248
name: cytosolic oxoglutarate dehydrogenase complex
namespace: cellular_component
def:
  "A cytosolic complex of multiple copies of three enzymatic components: oxoglutarate dehydrogenase (lipoamide) ; EC:1.2.4.2 (E1), dihydrolipoamide S-succinyltransferase ; EC:2.3.1.61 (E2) and dihydrolipoamide dehydrogenase ; EC:1.8.1.4 (E3); catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and carbon dioxide (CO2)." [GOC:mtg_sensu, PMID:10848975]


id: GO:0045249
name: cytosol pyruvate dehydrogenase (lipoamide) phosphatase complex
namespace: cellular_component
def:
  "A cytosolic complex of a regulatory and catalytic subunit that catalyzes the dephosphorylation and concomitant reactivation of the alpha subunit of the E1 component of the pyruvate dehydrogenase complex." [GOC:mtg_sensu, PMID:9395502]


id: GO:0045250
name: cytosolic pyruvate dehydrogenase complex
namespace: cellular_component
def:
  "Complex that carries out the oxidative decarboxylation of pyruvate to form acetyl-CoA; comprises subunits possessing three catalytic activities: pyruvate dehydrogenase (E1), dihydrolipoamide S-acetyltransferase (E2), and dihydrolipoamide dehydrogenase (E3). Usually contains fewer subunits than its eukaryotic counterpart; for example, the E. coli complex contains 12 E1 dimers, 8 E2 trimers, and 6 E3 dimers arranged in highly symmetric cubic order." [GOC:mtg_sensu, ISBN:0471331309, ISBN:0716720094]


id: GO:0045251
name: electron transfer flavoprotein complex
namespace: cellular_component
def:
  "A protein complex containing flavin adenine dinucleotide (FAD) and acyl-CoA dehydrogenase, which form a system that oxidizes an acyl-CoA molecule and reduces ubiquinone and other acceptors in the mitochondrial electron transport system." [ISBN:0198506732]


id: GO:0045252
name: oxoglutarate dehydrogenase complex
namespace: cellular_component
def:
  "A complex of multiple copies of three enzymatic components: oxoglutarate dehydrogenase (lipoamide) ; EC:1.2.4.2 (E1), dihydrolipoamide S-succinyltransferase ; EC:2.3.1.61 (E2) and dihydrolipoamide dehydrogenase ; EC:1.8.1.4 (E3); catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and carbon dioxide (CO2)." [MetaCyc:CPLX66-42, PMID:10848975]


id: GO:0045253
name: pyruvate dehydrogenase (lipoamide) phosphatase complex
namespace: cellular_component
def:
  "A complex of a regulatory and catalytic subunit that catalyzes the dephosphorylation and concomitant reactivation of the alpha subunit of the E1 component of the pyruvate dehydrogenase complex." [PMID:9395502]


id: GO:0045254
name: pyruvate dehydrogenase complex
namespace: cellular_component
def:
  "Complex that carries out the oxidative decarboxylation of pyruvate to form acetyl-CoA; comprises subunits possessing three catalytic activities: pyruvate dehydrogenase (E1), dihydrolipoamide S-acetyltransferase (E2), and dihydrolipoamide dehydrogenase (E3)." [ISBN:0716720094]


id: GO:0045257
name: succinate dehydrogenase complex (ubiquinone)
namespace: cellular_component
def:
  "The enzyme that catalyzes the oxidation of succinate and ubiquinone to fumarate and ubiquinol; involved in aerobic respiration, repressed in anaerobic respiration." [GOC:kd, ISBN:0198547684]


id: GO:0045258
name: plasma membrane succinate dehydrogenase complex (ubiquinone)
namespace: cellular_component
def:
  "The enzyme, located in the plasma membrane, that catalyzes the oxidation of succinate and ubiquinone to fumarate and ubiquinol; involved in aerobic respiration, repressed in anaerobic respiration." [GOC:kd, GOC:mtg_sensu, ISBN:0198547684]


id: GO:0045259
name: proton-transporting ATP synthase complex
namespace: cellular_component
def:
  "A proton-transporting two-sector ATPase complex that catalyzes the phosphorylation of ADP to ATP during oxidative phosphorylation. The complex comprises a membrane sector (F0) that carries out proton transport and a cytoplasmic compartment sector (F1) that catalyzes ATP synthesis by a rotational mechanism; the extramembrane sector (containing 3 a and 3 b subunits) is connected via the d-subunit to the membrane sector by several smaller subunits. Within this complex, the g and e subunits and the 9-12 c subunits rotate by consecutive 120 degree angles and perform parts of ATP synthesis. This movement is driven by the hydrogen ion electrochemical potential gradient." [EC:3.6.3.14, ISBN:0198547684, ISBN:0716743663]


id: GO:0045260
name: plasma membrane proton-transporting ATP synthase complex
namespace: cellular_component
def:
  "A proton-transporting ATP synthase complex found in the plasma membrane. Examples of this component are found in Bacterial species." [GOC:mah, GOC:mtg_sensu, ISBN:0198547684]


id: GO:0045261
name: proton-transporting ATP synthase complex, catalytic core F(1)
namespace: cellular_component
def:
  "The sector of a hydrogen-transporting ATP synthase complex in which the catalytic activity resides; it comprises the catalytic core and central stalk, and is peripherally associated with a membrane, such as the plasma membrane or the mitochondrial inner membrane, when the entire ATP synthase is assembled." [GOC:mah, PMID:10838056]


id: GO:0045262
name: plasma membrane proton-transporting ATP synthase complex, catalytic core F(1)
namespace: cellular_component
def:
  "The catalytic sector of the plasma membrane hydrogen-transporting ATP synthase; it comprises the catalytic core and central stalk, and is peripherally associated with the plasma membrane when the entire ATP synthase is assembled. Examples of this component are found in Bacterial species." [GOC:mah, GOC:mtg_sensu, PMID:10838056]


id: GO:0045263
name: proton-transporting ATP synthase complex, coupling factor F(o)
namespace: cellular_component
def:
  "All non-F1 subunits of a hydrogen-transporting ATP synthase, including integral and peripheral membrane proteins." [PMID:10838056]


id: GO:0045264
name: plasma membrane proton-transporting ATP synthase complex, coupling factor F(o)
namespace: cellular_component
def:
  "All non-F1 subunits of the plasma membrane hydrogen-transporting ATP synthase, including integral and peripheral plasma membrane proteins." [GOC:mah, GOC:mtg_sensu, PMID:10838056]


id: GO:0045265
name: proton-transporting ATP synthase, stator stalk
namespace: cellular_component
def:
  "One of two stalks that connect the catalytic core of the hydrogen-transporting ATP synthase to the membrane-associated Fo proteins; is thought to prevent futile rotation of the catalytic core." [PMID:10838056]


id: GO:0045266
name: plasma membrane proton-transporting ATP synthase, stator stalk
namespace: cellular_component
def:
  "One of two stalks that connect the catalytic core of the hydrogen-transporting ATP synthase to the plasma membrane-associated F0 proteins; is thought to prevent futile rotation of the catalytic core. Examples of this component are found in Bacterial species." [GOC:mtg_sensu, PMID:10838056]


id: GO:0045267
name: proton-transporting ATP synthase, catalytic core
namespace: cellular_component
def:
  "The hexamer that possesses the catalytic activity of the mitochondrial hydrogen-transporting ATP synthase." [PMID:10838056]


id: GO:0045268
name: plasma membrane proton-transporting ATP synthase, catalytic core
namespace: cellular_component
def:
  "The hexamer that possesses the catalytic activity of the plasma membrane hydrogen-transporting ATP synthase. Examples of this component are found in Bacterial species." [GOC:mtg_sensu, PMID:10838056]


id: GO:0045269
name: proton-transporting ATP synthase, central stalk
namespace: cellular_component
def:
  "One of two stalks that connect the catalytic core of the hydrogen-transporting ATP synthase to the membrane-associated Fo proteins; rotates within the catalytic core during catalysis." [PMID:10838056]


id: GO:0045270
name: plasma membrane proton-transporting ATP synthase, central stalk
namespace: cellular_component
def:
  "One of two stalks that connect the catalytic core of the hydrogen-transporting ATP synthase to the plasma membrane-associated Fo proteins; rotates within the catalytic core during catalysis. Examples of this component are found in Bacterial species." [GOC:mtg_sensu, PMID:10838056]


id: GO:0045271
name: respiratory chain complex I
namespace: cellular_component
def:
  "Respiratory chain complex I is an enzyme of the respiratory chain. It consists of several polypeptide chains and is L-shaped, with a horizontal arm lying in the membrane and a vertical arm that projects into the matrix. The electrons of NADH enter the chain at this complex." [GOC:imk, GOC:jid, ISBN:0716749556]


id: GO:0045272
name: plasma membrane respiratory chain complex I
namespace: cellular_component
def:
  "A subcomplex of the respiratory chain located in the plasma membrane. It contains about 25 different polypeptide subunits, including NADH dehydrogenase (ubiquinone), flavin mononucleotide and several different iron-sulfur clusters containing non-heme iron. The iron undergoes oxidation-reduction between Fe(II) and Fe(III), and catalyzes proton translocation linked to the oxidation of NADH by ubiquinone. Examples of this component are found in bacterial species." [GOC:mtg_sensu, ISBN:0198547684]


id: GO:0045273
name: respiratory chain complex II
namespace: cellular_component
def:
  "A part of the respiratory chain, containing the four polypeptide subunits of succinate dehydrogenase, flavin-adenine dinucleotide and iron-sulfur. Catalyzes the oxidation of succinate by ubiquinone. Connects the TCA cycle with the respiratory chain." [ISBN:0198547684]


id: GO:0045274
name: plasma membrane respiratory chain complex II
namespace: cellular_component
def:
  "A part of the respiratory chain located in the plasma membrane, containing the four polypeptide subunits of succinate dehydrogenase, flavin-adenine dinucleotide and iron-sulfur. Catalyzes the oxidation of succinate by ubiquinone. Connects the TCA cycle with the respiratory chain. Examples of this component are found in bacterial species." [GOC:mtg_sensu, ISBN:0198547684]


id: GO:0045275
name: respiratory chain complex III
namespace: cellular_component
def:
  "A protein complex that transfers electrons from ubiquinol to cytochrome c and translocates two protons across a membrane. The complex contains a core structure of three catalytic subunits: cytochrome b, the Rieske iron sulfur protein (ISP), and cytochrome c1, which are arranged in an integral membrane-bound dimeric complex; additional subunits are present, and vary among different species." [PMID:16228398, PMID:16352458, PMID:17200733]


id: GO:0045276
name: plasma membrane respiratory chain complex III
namespace: cellular_component
def:
  "A part of the respiratory chain located in the plasma membrane, containing about 10 polypeptide subunits including four redox centers: cytochrome b/b6, cytochrome c1 and an 2Fe-2S cluster. Catalyzes the oxidation of ubiquinol by oxidized cytochrome c1. Examples of this component are found in bacterial species." [GOC:mtg_sensu, ISBN:0198547684]


id: GO:0045277
name: respiratory chain complex IV
namespace: cellular_component
def:
  "A part of the respiratory chain, containing the 13 polypeptide subunits of cytochrome c oxidase, including cytochrome a and cytochrome a3. Catalyzes the oxidation of reduced cytochrome c by dioxygen (O2)." [ISBN:0198547684]


id: GO:0045278
name: plasma membrane respiratory chain complex IV
namespace: cellular_component
def:
  "A part of the respiratory chain located in the plasma membrane, containing the 13 polypeptide subunits of cytochrome c oxidase, including cytochrome a and cytochrome a3. Catalyzes the oxidation of reduced cytochrome c by dioxygen (O2). Examples of this component are found in bacterial species." [GOC:mtg_sensu, ISBN:0198547684]


id: GO:0045281
name: succinate dehydrogenase complex
namespace: cellular_component
def:
  "A multimeric complex which consists of flavoprotein (subunit A ; InterPro:IPR003952), iron-sulfur protein (subunit B) and membrane-bound cytochrome b560 (subunit C; InterPro:IPR000701). In some Archaea, the membrane-bound subunits (C or C and D) do not necessarily contain heme. Membrane-bound subunits can bind or react with quinones." [GOC:kd, InterPro:IPR000701]


id: GO:0045282
name: plasma membrane succinate dehydrogenase complex
namespace: cellular_component
def:
  "A multimeric complex which consists of flavoprotein (subunit A ; InterPro:IPR003952), iron-sulfur protein (subunit B) and membrane-bound cytochrome b560 (subunit C; InterPro:IPR000701). In some Archaea, the membrane-bound subunits (C or C and D) do not necessarily contain heme. Membrane-bound subunits can bind/react with quinones. Examples of this component are found in Bacterial species." [GOC:kd, GOC:mtg_sensu, InterPro:IPR000701]


id: GO:0045283
name: fumarate reductase complex
namespace: cellular_component
def:
  "A membrane-bound flavoenzyme complex consisting of four subunits, A, B, C, and D. A and B comprise the membrane-extrinsic catalytic domain and C (InterPro:IPR003510; InterPro:IPR004224) and D (InterPro:IPR003418) link the catalytic centers to the electron-transport chain. This family consists of the 13 kDa hydrophobic subunit D. This component may be required to anchor the catalytic components of the fumarate reductase complex to the cytoplasmic membrane. Fumarate reductase couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, in a reaction opposite to that catalyzed by the related complex II of the respiratory chain (succinate dehydrogenase-(ubiquinone))." [InterPro:IPR003418, InterPro:IPR004224]


id: GO:0045284
name: plasma membrane fumarate reductase complex
namespace: cellular_component
def:
  "A membrane-bound flavoenzyme complex consisting of four subunits, A, B, C, and D. A and B comprise the membrane-extrinsic catalytic domain and C (InterPro:IPR003510; InterPro:IPR00224) and D (InterPro:IPR003418) link the catalytic centers to the electron-transport chain. In some species, the complex has only three subunits, and in these cases, there is only one membrane anchor instead of two. This family consists of the 13 kDa hydrophobic subunit D. This component may be required to anchor the catalytic components of the fumarate reductase complex to the cytoplasmic membrane. Fumarate reductase couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, in a reaction opposite to that catalyzed by the related complex II of the respiratory chain (succinate dehydrogenase-(ubiquinone)). Examples of this component are found in bacterial species." [GOC:mtg_sensu, InterPro:IPR003418, InterPro:IPR004224]


id: GO:0045289
name: luciferin monooxygenase activity
namespace: molecular_function
def:
  "Catalysis of the generalized reaction: luciferin + O2 = oxidized luciferin + CO2 + light. There may be additional substrates and reactants involved in the reaction. The reaction results in light emission as luciferin returns to the ground state after enzymatic oxidation." [GOC:bf]


id: GO:0045290
name: D-arabinose 1-dehydrogenase [NAD(P)+] activity
namespace: molecular_function
def:
  "Catalysis of the reaction: D-arabinose + NAD(P)+ = D-arabinono-1,4-lactone + NAD(P)H + H+." [EC:1.1.1.117]


id: GO:0045291
name: mRNA trans splicing, SL addition
namespace: biological_process
def:
  "The joining together of two independently transcribed RNAs, where the one that provides the 5' portion of the final mRNA is from a splice leader RNA (SL-RNA). The SL-RNA, or mini-exon donor sequence, is added to the 5'-end of the acceptor RNA molecule which provides the mRNA body." [GOC:krc, ISBN:0879695897, PMID:2675423]


id: GO:0045292
name: mRNA cis splicing, via spliceosome
namespace: biological_process
def:
  "The joining together, after removal of an intervening sequence composed of one or more introns, of two segments of the same RNA molecule via spliceosomal catalysis to produce an mRNA composed only of exon sequences that all came from the same primary transcript." [GOC:krc, http://calspace.ucsd.edu/origins/Glossary/C.htm, ISBN:0879695897]


id: GO:0045293
name: mRNA editing complex
namespace: cellular_component
def:
  "A protein complex that posttranscriptionally catalyzes insertion, deletion or substitution of nucleotides at multiple sites within nascent mRNA transcripts to produce mature mRNAs in eukaryotes." [http://www.ejbiotechnology.info/content/vol1/issue1/full/4/, PMID:11564867, PMID:12139607]


id: GO:0045294
name: alpha-catenin binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with the alpha subunit of the catenin complex." [GOC:bf]


id: GO:0045295
name: gamma-catenin binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with the gamma subunit of the catenin complex." [GOC:bf]


id: GO:0045296
name: cadherin binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with cadherin, a type I membrane protein involved in cell adhesion." [GOC:bf]


id: GO:0045298
name: tubulin complex
namespace: cellular_component
def:
  "A heterodimer of tubulins alpha and beta that constitutes the protomer for microtubule assembly." [ISBN:0716731363]


id: GO:0045299
name: otolith mineralization
namespace: biological_process
def:
  "The precipitation of specific crystal forms of calcium carbonate with extracellular matrix proteins in the otolith organs of the vertebrate inner ear." [GOC:dsf, PMID:15581873]


id: GO:0045300
name: acyl-[acyl-carrier-protein] desaturase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: stearoyl-[acyl-carrier protein] + reduced acceptor + O2 = oleoyl-[acyl-carrier protein] + acceptor + H2O. The enzyme requires ferredoxin." [EC:1.14.19.2]


id: GO:0045301
name: tRNA-(2-methylthio-N-6-(cis-hydroxy)isopentenyl adenosine)-hydroxylase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: tRNA-(2-methylthio-N-6-isopentenyl adenosine) = tRNA-(2-methylthio-N-6-(cis-hydroxy)isopentenyl adenosine) + O2. 2-methylthio-N-6-isopentenyl adenosine is also known as ms2i6A; 2-methylthio-N-6-(cis-hydroxy)isopentenyl adenosine is also known as ms2io6A and 2-methylthio-cis-ribozeatin." [GOC:mlg, PMID:8253666]


id: GO:0045302
name: choloylglycine hydrolase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholan-24-oylglycine + H2O = 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholanate + glycine." [EC:3.5.1.24]


id: GO:0045303
name: diaminobutyrate-2-oxoglutarate transaminase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 2-oxoglutarate + L-2,4-diaminobutyrate = L-aspartate 4-semialdehyde + L-glutamate." [EC:2.6.1.76, RHEA:11163]


id: GO:0045304
name: regulation of establishment of competence for transformation
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of the process in which a cell becomes able to take up and incorporate extracellular DNA into its genome." [GOC:mlg]


id: GO:0045305
name: obsolete regulator of establishment of competence for transformation activity
namespace: molecular_function
def:
  "OBSOLETE. Functions to either promote or inhibit the establishment of competence for transformation." [GOC:mlg]


id: GO:0045309
name: protein phosphorylated amino acid binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with a phosphorylated amino acid residue within a protein." [GOC:go_curators]


id: GO:0045310
name: obsolete phosphoserine/phosphothreonine binding
namespace: molecular_function
def:
  "OBSOLETE. Interacting selectively with a phosphorylated serine or threonine residue within a protein." [GOC:go_curators]


id: GO:0045311
name: invasive growth in response to pheromone
namespace: biological_process
def:
  "The growth of colonies in filamentous chains of cells as a result of a pheromone stimulus." [GOC:ai, GOC:dph, GOC:mcc]


id: GO:0045312
name: nor-spermidine biosynthetic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of nor-spermidine, a compound related to spermidine, N-(3-aminopropyl)-1,4-diaminobutane." [GOC:go_curators]


id: GO:0045313
name: rhabdomere membrane biogenesis
namespace: biological_process
def:
  "A process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a rhabdomere membrane." [GOC:jl]


id: GO:0045314
name: regulation of compound eye photoreceptor development
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of compound eye photoreceptor development." [GOC:bf]


id: GO:0045315
name: positive regulation of compound eye photoreceptor development
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of compound eye photoreceptor development." [GOC:bf]


id: GO:0045316
name: negative regulation of compound eye photoreceptor development
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of compound eye photoreceptor development." [GOC:bf]


id: GO:0045317
name: equator specification
namespace: biological_process
def:
  "The formation and development of the equator that forms the boundary between the photoreceptors in the dorsal sector of the eye and those in the ventral sector, dividing the eye into dorsal and ventral halves." [GOC:bf]


id: GO:0045319
name: obsolete SRP-independent cotranslational protein-membrane targeting, translocation
namespace: biological_process
def:
  "OBSOLETE. The process during cotranslational membrane targeting wherein proteins move across a membrane. This process is independent of SRP and signal recognition." [GOC:ai]


id: GO:0045320
name: chloroplast proton-transporting ATP synthase complex
namespace: cellular_component
def:
  "A proton-transporting ATP synthase complex found in the chloroplast thylakoid membrane; it catalyzes the phosphorylation of ADP to ATP during photo-phosphorylation." [GOC:mtg_sensu, GOC:pj, ISBN:0716743663]


id: GO:0045321
name: leukocyte activation
namespace: biological_process
def:
  "A change in morphology and behavior of a leukocyte resulting from exposure to a specific antigen, mitogen, cytokine, cellular ligand, or soluble factor." [GOC:add]


id: GO:0045322
name: unmethylated CpG binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with unmethylated CpG motifs. Unmethylated CpG dinucleotides are often associated with gene promoters." [GOC:ai, PMID:10688657]


id: GO:0045323
name: interleukin-1 receptor complex
namespace: cellular_component
def:
  "A protein complex that binds interleukin-1; comprises an alpha and a beta subunit." [GOC:mah, InterPro:IPR004075]


id: GO:0045324
name: late endosome to vacuole transport
namespace: biological_process
def:
  "The directed movement of substances from late endosomes to the vacuole. In yeast, after transport to the prevacuolar compartment, endocytic content is delivered to the late endosome and on to the vacuole. This pathway is analogous to endosome to lysosome transport." [PMID:11872141]


id: GO:0045326
name: protein-DNA covalent cross-linking via the 3'-end to peptidyl-tyrosine
namespace: biological_process
def:
  "The formation of a covalent cross-link between DNA and a peptidyl-tyrosine residue by the formation of O4'-(phospho-3'-DNA)-L-tyrosine." [RESID:AA0323]


id: GO:0045328
name: cytochrome P450 4A1-heme linkage
namespace: biological_process
def:
  "The covalent linkage of heme to cytochrome P450 4A1 via hydroxyheme-L-glutamyl ester." [GOC:cjm, RESID:AA0324]


id: GO:0045329
name: carnitine biosynthetic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of carnitine (hydroxy-trimethyl aminobutyric acid), a compound that participates in the transfer of acyl groups across the inner mitochondrial membrane." [GOC:jl, ISBN:0198506732]


id: GO:0045330
name: aspartyl esterase activity
namespace: molecular_function
def:
  "Catalysis of the hydrolysis of an ester bond by a mechanism involving a catalytically active aspartic acid residue." [GOC:mah, UniProtKB-KW:KW-0063]


id: GO:0045331
name: obsolete coenzyme-M-7-mercaptoheptanoylthreonine-phosphate-heterodisulfide hydrogenase activity
namespace: molecular_function
def:
  "OBSOLETE. Catalysis of the reaction: coenzyme-M 7-mercaptoheptanoylthreonine-phosphate heterodisulfide + H2 = coenzyme-M + N-(7-mercaptoheptanoyl)threonine O3-phosphate." [EC:1.12.99.2]


id: GO:0045332
name: phospholipid translocation
namespace: biological_process
def:
  "The movement of a phospholipid molecule from one leaflet of a membrane bilayer to the opposite leaflet." [ISBN:0815316194, PMID:16452632, PMID:20043909, PMID:20302864]


id: GO:0045333
name: cellular respiration
namespace: biological_process
def:
  "The enzymatic release of energy from inorganic and organic compounds (especially carbohydrates and fats) which either requires oxygen (aerobic respiration) or does not (anaerobic respiration)." [GOC:das, ISBN:0140513590, ISBN:0198506732]


id: GO:0045334
name: clathrin-coated endocytic vesicle
namespace: cellular_component
def:
  "A clathrin-coated, membrane-bounded intracellular vesicle formed by invagination of the plasma membrane around an extracellular substance." [GOC:go_curators]


id: GO:0045335
name: phagocytic vesicle
namespace: cellular_component
def:
  "A membrane-bounded intracellular vesicle that arises from the ingestion of particulate material by phagocytosis." [GOC:go_curators, ISBN:0198506732]


id: GO:0045336
name: clathrin-coated phagocytic vesicle
namespace: cellular_component
def:
  "A clathrin-coated, membrane-bounded intracellular vesicle that arises from the ingestion of particulate material by phagocytosis." [GOC:go_curators, ISBN:0198506732]


id: GO:0045338
name: farnesyl diphosphate metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving farnesyl diphosphate, an intermediate in carotenoid, sesquiterpene, squalene and sterol biosynthesis, as well as a substrate in protein farnesylation." [GOC:go_curators]


id: GO:0045339
name: farnesyl diphosphate catabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the breakdown of farnesyl diphosphate." [GOC:go_curators]


id: GO:0045341
name: MHC class I biosynthetic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of major histocompatibility protein class I." [GOC:go_curators]


id: GO:0045342
name: MHC class II biosynthetic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of major histocompatibility protein class II." [GOC:go_curators]


id: GO:0045343
name: regulation of MHC class I biosynthetic process
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of MHC class I." [GOC:go_curators]


id: GO:0045344
name: negative regulation of MHC class I biosynthetic process
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of MHC class I." [GOC:go_curators]


id: GO:0045345
name: positive regulation of MHC class I biosynthetic process
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of MHC class I." [GOC:go_curators]


id: GO:0045346
name: regulation of MHC class II biosynthetic process
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of MHC class II." [GOC:go_curators]


id: GO:0045347
name: negative regulation of MHC class II biosynthetic process
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of MHC class II." [GOC:go_curators]


id: GO:0045348
name: positive regulation of MHC class II biosynthetic process
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of MHC class II." [GOC:go_curators]


id: GO:0045349
name: interferon-alpha biosynthetic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of interferon-alpha." [GOC:go_curators]


id: GO:0045350
name: interferon-beta biosynthetic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of interferon-beta." [GOC:go_curators]


id: GO:0045351
name: type I interferon biosynthetic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of any type I interferon. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families." [GOC:add]


id: GO:0045354
name: regulation of interferon-alpha biosynthetic process
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interferon-alpha." [GOC:go_curators]


id: GO:0045355
name: negative regulation of interferon-alpha biosynthetic process
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interferon-alpha." [GOC:go_curators]


id: GO:0045356
name: positive regulation of interferon-alpha biosynthetic process
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interferon-alpha." [GOC:go_curators]


id: GO:0045357
name: regulation of interferon-beta biosynthetic process
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interferon-beta." [GOC:go_curators]


id: GO:0045358
name: negative regulation of interferon-beta biosynthetic process
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interferon-beta." [GOC:go_curators]


id: GO:0045359
name: positive regulation of interferon-beta biosynthetic process
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interferon-beta." [GOC:go_curators]


id: GO:0045360
name: regulation of interleukin-1 biosynthetic process
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-1." [GOC:go_curators]


id: GO:0045361
name: negative regulation of interleukin-1 biosynthetic process
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-1." [GOC:go_curators]


id: GO:0045362
name: positive regulation of interleukin-1 biosynthetic process
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-1." [GOC:go_curators]


id: GO:0045363
name: regulation of interleukin-11 biosynthetic process
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-11." [GOC:go_curators]


id: GO:0045364
name: negative regulation of interleukin-11 biosynthetic process
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-11." [GOC:go_curators]


id: GO:0045365
name: positive regulation of interleukin-11 biosynthetic process
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-11." [GOC:go_curators]


id: GO:0045366
name: regulation of interleukin-13 biosynthetic process
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-13." [GOC:go_curators]


id: GO:0045367
name: negative regulation of interleukin-13 biosynthetic process
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-13." [GOC:go_curators]


id: GO:0045368
name: positive regulation of interleukin-13 biosynthetic process
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-13." [GOC:go_curators]


id: GO:0045369
name: regulation of interleukin-14 biosynthetic process
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-14." [GOC:go_curators]


id: GO:0045370
name: negative regulation of interleukin-14 biosynthetic process
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-14." [GOC:go_curators]


id: GO:0045371
name: positive regulation of interleukin-14 biosynthetic process
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-14." [GOC:go_curators]


id: GO:0045372
name: regulation of interleukin-15 biosynthetic process
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-15." [GOC:go_curators]


id: GO:0045373
name: negative regulation of interleukin-15 biosynthetic process
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-15." [GOC:go_curators]


id: GO:0045374
name: positive regulation of interleukin-15 biosynthetic process
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-15." [GOC:go_curators]


id: GO:0045375
name: regulation of interleukin-16 biosynthetic process
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-16." [GOC:go_curators]


id: GO:0045376
name: negative regulation of interleukin-16 biosynthetic process
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-16." [GOC:go_curators]


id: GO:0045377
name: positive regulation of interleukin-16 biosynthetic process
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-16." [GOC:go_curators]


id: GO:0045378
name: regulation of interleukin-17 biosynthetic process
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of any member of the interleukin-17 family of cytokines." [GOC:add, GOC:go_curators]


id: GO:0045379
name: negative regulation of interleukin-17 biosynthetic process
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of any member of the interleukin-17 family of cytokines." [GOC:add, GOC:go_curators]


id: GO:0045380
name: positive regulation of interleukin-17 biosynthetic process
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of any member of the interleukin-17 family of cytokines." [GOC:add, GOC:go_curators]


id: GO:0045381
name: regulation of interleukin-18 biosynthetic process
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-18." [GOC:go_curators]


id: GO:0045382
name: negative regulation of interleukin-18 biosynthetic process
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-18." [GOC:go_curators]


id: GO:0045383
name: positive regulation of interleukin-18 biosynthetic process
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-18." [GOC:go_curators]


id: GO:0045384
name: regulation of interleukin-19 biosynthetic process
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-19." [GOC:go_curators]


id: GO:0045385
name: negative regulation of interleukin-19 biosynthetic process
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-19." [GOC:go_curators]


id: GO:0045386
name: positive regulation of interleukin-19 biosynthetic process
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-19." [GOC:go_curators]


id: GO:0045387
name: regulation of interleukin-20 biosynthetic process
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-20." [GOC:go_curators]


id: GO:0045388
name: negative regulation of interleukin-20 biosynthetic process
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-20." [GOC:go_curators]


id: GO:0045389
name: positive regulation of interleukin-20 biosynthetic process
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-20." [GOC:go_curators]


id: GO:0045390
name: regulation of interleukin-21 biosynthetic process
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-21." [GOC:go_curators]


id: GO:0045391
name: negative regulation of interleukin-21 biosynthetic process
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-21." [GOC:go_curators]


id: GO:0045392
name: positive regulation of interleukin-21 biosynthetic process
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-21." [GOC:go_curators]


id: GO:0045393
name: regulation of interleukin-22 biosynthetic process
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-22." [GOC:go_curators]


id: GO:0045394
name: negative regulation of interleukin-22 biosynthetic process
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-22." [GOC:go_curators]


id: GO:0045395
name: positive regulation of interleukin-22 biosynthetic process
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-22." [GOC:go_curators]


id: GO:0045396
name: regulation of interleukin-23 biosynthetic process
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-23." [GOC:go_curators]


id: GO:0045397
name: negative regulation of interleukin-23 biosynthetic process
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-23." [GOC:go_curators]


