# go

id: GO:0035983
name: response to trichostatin A
namespace: biological_process
def:
  "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a trichostatin A stimulus." [CHEBI:46024, GOC:yaf, PMID:20181743]


id: GO:0035984
name: cellular response to trichostatin A
namespace: biological_process
def:
  "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a trichostatin A stimulus." [CHEBI:46024, GOC:yaf, PMID:20181743]


id: GO:0035985
name: senescence-associated heterochromatin focus
namespace: cellular_component
def:
  "A transcriptionally-silent heterochromatin structure present in senescent cells. Contains the condensed chromatin of one chromosome and is enriched for histone modifications. Thought to repress expression of proliferation-promoting genes." [GOC:yaf, PMID:15621527, PMID:21248468]


id: GO:0035986
name: senescence-associated heterochromatin focus assembly
namespace: biological_process
def:
  "The assembly of chromatin into senescence-associated heterochromatin foci (SAHF), transcriptionally-silent heterochromatin structures present in senescent cells, containing the condensed chromatin of one chromosome, and enriched for histone modifications. Formation of these chromatin structures is thought to repress expression of proliferation-promoting genes." [GOC:yaf, PMID:15621527, PMID:21248468]


id: GO:0035987
name: endodermal cell differentiation
namespace: biological_process
def:
  "The process in which a relatively unspecialized cell acquires the specialized features of an endoderm cell, a cell of the inner of the three germ layers of the embryo." [CL:0000223, GOC:yaf, PMID:17624332]


id: GO:0035988
name: chondrocyte proliferation
namespace: biological_process
def:
  "The multiplication or reproduction of chondrocytes by cell division, resulting in the expansion of their population. A chondrocyte is a polymorphic cell that forms cartilage." [CL:0000138, GOC:yaf, PMID:21484705]


id: GO:0035989
name: tendon development
namespace: biological_process
def:
  "The process whose specific outcome is the progression of a tendon over time, from its formation to the mature structure. A tendon is a fibrous, strong, connective tissue that connects muscle to bone or integument and is capable of withstanding tension. Tendons and muscles work together to exert a pulling force." [GOC:yaf, PMID:21412429, UBERON:0000043]


id: GO:0035990
name: tendon cell differentiation
namespace: biological_process
def:
  "The process in which a relatively unspecialized cell acquires the specialized features of a tendon cell. Tendon cell are elongated fibrocytes in which the cytoplasm is stretched between the collagen fibres of the tendon. Tendon cells have a central cell nucleus with a prominent nucleolus, a well-developed rough endoplasmic reticulum, and are responsible for synthesis and turnover of tendon fibres and ground substance." [CL:0000388, GOC:yaf, PMID:21412429]


id: GO:0035991
name: nitric oxide sensor activity
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with and responding, e.g. by conformational change, to changes in the cellular level of nitric oxide (NO)." [GOC:kmv, PMID:21491957]


id: GO:0035992
name: tendon formation
namespace: biological_process
def:
  "The process that gives rise to a tendon. This process pertains to the initial formation of a tendon from unspecified parts." [GOC:yaf, PMID:17567668, UBERON:0000043]


id: GO:0035993
name: deltoid tuberosity development
namespace: biological_process
def:
  "The process whose specific outcome is the progression of the deltoid tuberosity over time, from its formation to the mature structure. The deltoid tuberosity is the region on the shaft of the humerus to which the deltoid muscle attaches. The deltoid tuberosity develops through endochondral ossification in a two-phase process; an initiating tendon-dependent phase, and a muscle-dependent growth phase." [GOC:yaf, PMID:17567668, UBERON:0002498, Wikipedia:Deltoid_tuberosity]


id: GO:0035994
name: response to muscle stretch
namespace: biological_process
def:
  "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a myofibril being extended beyond its slack length." [GOC:BHF, GOC:vk, PMID:14583192]


id: GO:0035995
name: detection of muscle stretch
namespace: biological_process
def:
  "The series of events by which a muscle stretch stimulus is received by a cell and converted into a molecular signal." [PMID:14583192]


id: GO:0035996
name: rhabdomere microvillus
namespace: cellular_component
def:
  "Thin cylindrical membrane-covered projection on the surface of a rhabdomere." [GOC:bf, GOC:sart, PMID:14744998]


id: GO:0035997
name: rhabdomere microvillus membrane
namespace: cellular_component
def:
  "The portion of the plasma membrane surrounding a microvillus of a rhabdomere." [GOC:bf, GOC:sart, PMID:14744998]


id: GO:0035998
name: 7,8-dihydroneopterin 3'-triphosphate biosynthetic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of 7,8-dihydroneopterin 3'-triphosphate." [CHEBI:18372, GOC:yaf, UniPathway:UPA00848]


id: GO:0035999
name: tetrahydrofolate interconversion
namespace: biological_process
def:
  "The chemical reactions and pathways by which one-carbon (C1) units are transferred between tetrahydrofolate molecules, to synthesise other tetrahydrofolate molecules." [GOC:yaf, PMID:1825999, UniPathway:UPA00193]


id: GO:0036000
name: mucocyst
namespace: cellular_component
def:
  "A small subcellular vesicle, surrounded by a membrane, in the pellicle of ciliate protozoans that discharges a mucus-like secretion." [GOC:mag, PMID:10723937, PMID:4629881]


id: GO:0036001
name: 'de novo' pyridoxal 5'-phosphate biosynthetic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of pyridoxal 5'-phosphate, the active form of vitamin B6, from simpler components." [GOC:bf, GOC:yaf, MetaCyc:PYRIDOXSYN-PWY]


id: GO:0036002
name: pre-mRNA binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with pre-messenger RNA (pre-mRNA), an intermediate molecule between DNA and protein that may contain introns and, at least in part, encodes one or more proteins. Introns are removed from pre-mRNA to form a mRNA molecule." [GOC:bf, GOC:kmv, PMID:21901112, SO:0000120]


id: GO:0036003
name: positive regulation of transcription from RNA polymerase II promoter in response to stress
namespace: biological_process
def:
  "Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:mcc]


id: GO:0036004
name: GAF domain binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with the GAF domain of a protein." [GOC:yaf, InterPro:IPR003018]


id: GO:0036005
name: response to macrophage colony-stimulating factor
namespace: biological_process
def:
  "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a macrophage colony-stimulating factor stimulus." [GOC:yaf, PMID:14687666]


id: GO:0036006
name: cellular response to macrophage colony-stimulating factor stimulus
namespace: biological_process
def:
  "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a macrophage colony-stimulating factor stimulus." [GOC:yaf, PMID:14687666]


id: GO:0036007
name: scintillon
namespace: cellular_component
def:
  "A body present in the cytoplasm of some dinoflagellates, which is the source of bioluminescence; emits light on acidification in the presence of oxygen." [GOC:mag, GOC:pr, PMID:4501583, PMID:5642469]


id: GO:0036008
name: sucrose catabolic process to fructose-6-phosphate and glucose-6-phosphate
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the breakdown of sucrose, which proceeds by phosphorylation of sucrose to form sucrose-6-phosphate. The subsequent actions of a hydrolase and a fructokinase generate fructose-6-phosphate and glucose-6-phosphate." [GOC:bf, GOC:dgf, MetaCyc:SUCUTIL-PWY]


id: GO:0036009
name: protein-glutamine N-methyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: S-adenosyl-L-methionine + protein L-glutamine = S-adenosyl-L-homocysteine + protein N-methyl-L-glutamine." [GOC:imk, PMID:11847124]


id: GO:0036010
name: protein localization to endosome
namespace: biological_process
def:
  "A process in which a protein is transported to, or maintained in, a location within an endosome." [GOC:yaf]


id: GO:0036011
name: imaginal disc-derived leg segmentation
namespace: biological_process
def:
  "Division of an imaginal disc-derived leg into a series of semi-repetitive parts or segments. The Drosophila leg, for example, has nine segments, each separated from the next by a flexible joint." [GOC:bf]


id: GO:0036012
name: cyanelle inner membrane
namespace: cellular_component
def:
  "The inner, i.e. lumen-facing, lipid bilayer of the cyanelle envelope; also faces the cyanelle stroma." [GOC:aa, PMID:18976493]


id: GO:0036014
name: cyanelle intermembrane space
namespace: cellular_component
def:
  "The region between the inner and outer lipid bilayers of the cyanelle envelope; includes the peptidoglycan layer." [GOC:aa]


id: GO:0036015
name: response to interleukin-3
namespace: biological_process
def:
  "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-3 stimulus." [GOC:yaf, PR:000001387]


id: GO:0036016
name: cellular response to interleukin-3
namespace: biological_process
def:
  "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-3 stimulus." [GOC:yaf, PR:000001387]


id: GO:0036017
name: response to erythropoietin
namespace: biological_process
def:
  "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an erythropoietin stimulus. Erythropoietin is a glycoprotein hormone that controls erythropoiesis." [GOC:yaf, PR:000007141]


id: GO:0036018
name: cellular response to erythropoietin
namespace: biological_process
def:
  "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an erythropoietin stimulus." [GOC:yaf, PR:000007141]


id: GO:0036019
name: endolysosome
namespace: cellular_component
def:
  "An transient hybrid organelle formed by fusion of a late endosome with a lysosome, and in which active degradation takes place." [GOC:pde, PMID:21878991]


id: GO:0036020
name: endolysosome membrane
namespace: cellular_component
def:
  "The lipid bilayer surrounding an endolysosome. An endolysosome is a transient hybrid organelle formed by fusion of a late endosome with a lysosome." [GOC:pde]


id: GO:0036021
name: endolysosome lumen
namespace: cellular_component
def:
  "The volume enclosed by the membrane of an endolysosome. An endolysosome is a transient hybrid organelle formed by fusion of a late endosome with a lysosome." [GOC:pde]


id: GO:0036022
name: limb joint morphogenesis
namespace: biological_process
def:
  "The process in which the anatomical structures of a limb joint are generated and organized. A limb joint is a flexible region that separates the rigid sections of a limb to allow movement in a controlled manner." [GOC:bf]


id: GO:0036023
name: embryonic skeletal limb joint morphogenesis
namespace: biological_process
def:
  "The process, occurring in the embryo, in which the anatomical structures of a skeletal limb joint are generated and organized. A skeletal limb joint is the connecting structure between the bones of a limb." [GOC:bf, Wikipedia:Joint]


id: GO:0036024
name: protein C inhibitor-TMPRSS7 complex
namespace: cellular_component
def:
  "A heterodimeric protein complex that contains protein C inhibitor (SERPINA5) and transmembrane protease serine 7 (TMPRSS7); formation of the complex inhibits the serine protease activity of transmembrane protease serine 7." [GOC:ans, PMID:15853774]


id: GO:0036025
name: protein C inhibitor-TMPRSS11E complex
namespace: cellular_component
def:
  "A heterodimeric protein complex that contains protein C inhibitor (SERPINA5) and transmembrane protease serine 11E (TMPRSS11E); formation of the complex inhibits the serine protease activity of transmembrane protease serine 11E." [GOC:ans, PMID:15328353]


id: GO:0036026
name: protein C inhibitor-PLAT complex
namespace: cellular_component
def:
  "A heterodimeric protein complex that contains protein C inhibitor (SERPINA5) and tissue-type plasminogen activator (PLAT); formation of the complex inhibits the serine protease activity of tissue-type plasminogen activator." [GOC:ans, PMID:10340997]


id: GO:0036027
name: protein C inhibitor-PLAU complex
namespace: cellular_component
def:
  "A heterodimeric protein complex that contains protein C inhibitor (SERPINA5) and urokinase-type plasminogen activator (PLAU); formation of the complex inhibits the serine protease activity of urokinase-type plasminogen activator." [GOC:ans, PMID:10340997, PMID:3501295, PMID:8536714]


id: GO:0036028
name: protein C inhibitor-thrombin complex
namespace: cellular_component
def:
  "A heterodimeric protein complex that contains protein C inhibitor (SERPINA5) and thrombin (F2); formation of the complex inhibits the serine protease activity of thrombin." [GOC:ans, PMID:6323392]


id: GO:0036029
name: protein C inhibitor-KLK3 complex
namespace: cellular_component
def:
  "A heterodimeric protein complex that contains protein C inhibitor (SERPINA5) and prostate-specific antigen (KLK3); formation of the complex inhibits the serine protease activity of prostate-specific antigen." [GOC:ans, PMID:1725227]


id: GO:0036030
name: protein C inhibitor-plasma kallikrein complex
namespace: cellular_component
def:
  "A heterodimeric protein complex that contains protein C inhibitor (SERPINA5) and plasma kallikrein (KLK1B); formation of the complex inhibits the serine protease activity of plasma kallikrein." [GOC:ans, PMID:2844223, PMID:8536714]


id: GO:0036031
name: recruitment of mRNA capping enzyme to RNA polymerase II holoenzyme complex
namespace: biological_process
def:
  "The process in which the guanylyltransferase enzyme responsible for adding a 7-methylguanosine cap on pre-mRNA becomes associated with the RNA polymerase II holoenzyme complex and the 5' end of a transcript." [GOC:bf, GOC:rb, PMID:10594013]


id: GO:0036032
name: neural crest cell delamination
namespace: biological_process
def:
  "The negative regulation of cell adhesion process in which a neural crest cell physically separates from the rest of the neural tube." [CL:0000333, PMID:17076275]


id: GO:0036033
name: mediator complex binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with a mediator complex. The mediator complex is a protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins." [GOC:yaf, PMID:18391015]


id: GO:0036034
name: mediator complex assembly
namespace: biological_process
def:
  "The aggregation, arrangement and bonding together of a set of components to form a mediator complex. The mediator complex is a protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins." [GOC:yaf, PMID:17641689]


id: GO:0036035
name: osteoclast development
namespace: biological_process
def:
  "The process whose specific outcome is the progression of a osteoclast from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate. An osteoclast is a specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue." [CL:0000092, GOC:bf, GOC:yaf]


id: GO:0036036
name: cardiac neural crest cell delamination
namespace: biological_process
def:
  "The negative regulation of cell adhesion process in which a cardiac neural crest cell physically separates from the rest of the neural tube." [GOC:hjd, PMID:17076275, PMID:18539270, PMID:20490374]


id: GO:0036037
name: CD8-positive, alpha-beta T cell activation
namespace: biological_process
def:
  "The change in morphology and behavior of a CD8-positive, alpha-beta T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific." [CL:0000625, GOC:yaf]


id: GO:0036038
name: TCTN-B9D complex
namespace: cellular_component
def:
  "A protein complex that is located at the ciliary transition zone and consists of tectonic proteins, B9 domain-containing proteins and other proteins. Acts as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. In mouse, members of the complex include TCTN1, TCTN2, B9D1, MKS1, CC2D2A and other proteins." [GOC:sp, PMID:21725307, PMID:22179047]


id: GO:0036039
name: curcumin metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving the polyphenol, curcumin." [CHEBI:3962, PMID:21467222]


id: GO:0036040
name: curcumin catabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the breakdown of the polyphenol, curcumin." [CHEBI:3962, PMID:21467222]


id: GO:0036041
name: long-chain fatty acid binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with a long-chain fatty acid. A long-chain fatty acid is a fatty acid with a chain length between C13 and C22." [CHEBI:15904, GOC:pm, PMID:12641450]


id: GO:0036042
name: long-chain fatty acyl-CoA binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with a long-chain fatty acyl-CoA. A long-chain fatty acyl-CoA is any derivative of coenzyme A in which the sulfhydryl group is in a thioester linkage with a long-chain fatty-acyl group. Long-chain fatty-acyl-CoAs have chain lengths of C13 or more." [CHEBI:33184, GOC:pm]


id: GO:0036043
name: obsolete microspike
namespace: cellular_component
def:
  "OBSOLETE. A dynamic, actin-rich projection extending from the surface of a migrating animal cell." [PMID:11429692, PMID:12153987, PMID:19095735]


id: GO:0036044
name: obsolete protein malonylation
namespace: biological_process
def:
  "OBSOLETE: The modification of a protein amino acid by the addition of a malonyl (CO-CH2-CO) group." [CHEBI:25134, GOC:sp]


id: GO:0036045
name: obsolete peptidyl-lysine malonylation
namespace: biological_process
def:
  "OBSOLETE. The addition of a malonyl group (CO-CH2-CO) to peptidyl-lysine to form N6-malonyl-L-lysine." [GOC:jsg, GOC:sp, PMID:21908771, PMID:22076378, RESID:AA0568]


id: GO:0036046
name: protein demalonylation
namespace: biological_process
def:
  "The removal of a malonyl group (CO-CH2-CO), from an amino acid residue within a protein or peptide." [GOC:sp, PMID:22076378]


id: GO:0036047
name: peptidyl-lysine demalonylation
namespace: biological_process
def:
  "The process of removing a malonyl group (CO-CH2-CO) from an malonylated lysine residue in a peptide or protein." [GOC:sp, PMID:22076378]


id: GO:0036048
name: protein desuccinylation
namespace: biological_process
def:
  "The removal of a succinyl group (CO-CH2-CH2-CO) from a residue in a peptide or protein." [CHEBI:37952, GOC:sp, PMID:22076378]


id: GO:0036049
name: peptidyl-lysine desuccinylation
namespace: biological_process
def:
  "The removal of a succinyl group (CO-CH2-CH2-CO) from a succinylated lysine residue in a peptide or protein." [CHEBI:37952, GOC:sp, PMID:22076378]


id: GO:0036050
name: peptidyl-lysine succinylation
namespace: biological_process
def:
  "The modification of a peptidyl-lysine residue by the addition of a succinyl group (CO-CH2-CH2-CO) to form N6-succinyl-L-lysine." [CHEBI:37952, GOC:jsg, GOC:sp, PMID:21151122, RESID:AA0545]


id: GO:0036051
name: protein localization to trailing edge
namespace: biological_process
def:
  "A process in which a protein is transported to, or maintained at, the trailing edge. The trailing edge is the area of a motile cell opposite to the direction of movement." [GOC:pf, GOC:pg]


id: GO:0036052
name: protein localization to uropod
namespace: biological_process
def:
  "A process in which a protein is transported to, or maintained in, a uropod. A uropod is a membrane projection with related cytoskeletal components at the trailing edge of a migrating cell." [GOC:add, GOC:pf, ISBN:0781735149, PMID:12714569, PMID:12787750]


id: GO:0036053
name: glomerular endothelium fenestra
namespace: cellular_component
def:
  "A large plasma membrane-lined circular pore that perforates the flattened glomerular endothelium and, unlike those of other fenestrated capillaries, is not spanned by diaphragms; the density and size of glomerular fenestrae account, at least in part, for the high permeability of the glomerular capillary wall to water and small solutes." [GOC:cjm, MP:0011454, PMID:19129259]


id: GO:0036054
name: protein-malonyllysine demalonylase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: protein-malonyllysine + H2O => protein-lysine + malonate. This reaction is the removal of a malonyl group (CO-CH2-CO) from a malonylated lysine residue of a protein or peptide." [GOC:sp, PMID:21908771, PMID:22076378]


id: GO:0036055
name: protein-succinyllysine desuccinylase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: protein-succinyllysine + H2O => protein-lysine + succinate. This reaction is the removal of a succinyl group (CO-CH2-CH2-CO) from a succinylated lysine residue of a protein or peptide." [GOC:sp, PMID:22076378]


id: GO:0036056
name: filtration diaphragm
namespace: cellular_component
def:
  "A specialized cell-cell junction found between the cells of the excretory system, which provides a barrier for filtration of blood or hemolymph." [GOC:mtg_kidney_jan10, GOC:sart, PMID:18971929]


id: GO:0036057
name: slit diaphragm
namespace: cellular_component
def:
  "A specialized cell-cell junction found between the interdigitating foot processes of the glomerular epithelium (the podocytes) in the vertebrate kidney, which is adapted for facilitating glomerular filtration." [GOC:mtg_kidney_jan10, GOC:rph, PMID:12386277, PMID:15994232, PMID:18971929, PMID:19478094]


id: GO:0036058
name: filtration diaphragm assembly
namespace: biological_process
def:
  "The aggregation, arrangement and bonding together of a set of components to form a filtration diaphragm, a specialized cell-cell junction found between the cells of the excretory system, which provides a barrier for filtration of blood or hemolymph." [GOC:mtg_kidney_jan10, PMID:18971929]


id: GO:0036059
name: nephrocyte diaphragm assembly
namespace: biological_process
def:
  "The aggregation, arrangement and bonding together of a set of components to form a nephrocyte diaphragm, a specialized cell-cell junction found between nephrocytes of the insect kidney." [GOC:mtg_kidney_jan10, GOC:sart, PMID:18971929]


id: GO:0036060
name: slit diaphragm assembly
namespace: biological_process
def:
  "The aggregation, arrangement and bonding together of a set of components to form a slit diaphragm, specialized cell-cell junction found between the interdigitating foot processes of the glomerular epithelium (the podocytes) in the vertebrate kidney, which is adapted for facilitating glomerular filtration." [GOC:mtg_kidney_jan10, GOC:rph, PMID:20633639]


id: GO:0036061
name: muscle cell chemotaxis toward tendon cell
namespace: biological_process
def:
  "The directed movement of a muscle cell towards a tendon cell in response to an external stimulus. Tendon cells, for example, produce positive guidance cues that attract muscle cells." [GOC:sart, PMID:19793885]


id: GO:0036062
name: presynaptic periactive zone
namespace: cellular_component
def:
  "A region that surrounds the active zone of the presynaptic plasma membrane, and is specialized for the control of synaptic development." [GOC:sart, PMID:10976048, PMID:18439406]


id: GO:0036063
name: acroblast
namespace: cellular_component
def:
  "A cone-shaped structure in the head of a spermatozoon, which is formed by the coalescence of Golgi fragments following the completion of meiosis. The acroblast is situated adjacent to the acrosomal vesicle." [GOC:sart, PMID:19934220]


id: GO:0036064
name: ciliary basal body
namespace: cellular_component
def:
  "A membrane-tethered, short cylindrical array of microtubules and associated proteins found at the base of a eukaryotic cilium (also called flagellum) that is similar in structure to a centriole and derives from it. The cilium basal body is the site of assembly and remodelling of the cilium and serves as a nucleation site for axoneme growth. As well as anchoring the cilium, it is thought to provide a selective gateway regulating the entry of ciliary proteins and vesicles by intraflagellar transport." [GOC:cilia, GOC:clt, PMID:21750193]


id: GO:0036065
name: fucosylation
namespace: biological_process
def:
  "The covalent attachment of a fucosyl group to an acceptor molecule." [CHEBI:62688, GOC:sart, PMID:19948734]


id: GO:0036066
name: protein O-linked fucosylation
namespace: biological_process
def:
  "The process of transferring a fucosyl group to a serine or threonine residues in a protein acceptor molecule, to form an O-linked protein-sugar linkage." [GOC:sart, PMID:19948734]


id: GO:0036067
name: light-dependent chlorophyll biosynthetic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of chlorophyll, any compound of magnesium complexed in a porphyrin (tetrapyrrole) ring and which functions as a photosynthetic pigment, from less complex precursors, which occur in the presence of light." [GOC:yaf, PMID:12242396]


id: GO:0036068
name: light-independent chlorophyll biosynthetic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of chlorophyll, any compound of magnesium complexed in a porphyrin (tetrapyrrole) ring and which functions as a photosynthetic pigment, from less complex precursors, which occur in the absence of light." [GOC:yaf, PMID:12242396, UniPathway:UPA00670]


id: GO:0036069
name: light-dependent bacteriochlorophyll biosynthetic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of a bacteriochlorophyll, which occur in the presence of light. Bacteriochlorophylls are any of the chlorophylls of photosynthetic bacteria; they differ structurally from the chlorophylls of higher plants." [GOC:yaf, PMID:12242396]


id: GO:0036070
name: light-independent bacteriochlorophyll biosynthetic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of a bacteriochlorophyll, which occur in the absence of light. Bacteriochlorophylls are any of the chlorophylls of photosynthetic bacteria; they differ structurally from the chlorophylls of higher plants." [GOC:yaf, PMID:12242396, UniPathway:UPA00671]


id: GO:0036071
name: N-glycan fucosylation
namespace: biological_process
def:
  "The process of transferring a fucosyl group to an N-glycan. An N-glycan is the carbohydrate portion of an N-glycoprotein when attached to a nitrogen from asparagine or arginine side-chains." [CHEBI:59520, GOC:sart, PMID:19948734]


id: GO:0036072
name: direct ossification
namespace: biological_process
def:
  "The formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance, that does not require the replacement of preexisting tissues." [GO_REF:0000034]


id: GO:0036073
name: perichondral ossification
namespace: biological_process
def:
  "Intramembranous ossification from the surface of a cartilage element as the perichondrium becomes a periosteum, without replacement of cartilage." [GO_REF:0000034]


id: GO:0036074
name: metaplastic ossification
namespace: biological_process
def:
  "Direct ossification in which bone formation occurs as result of the direct transformation of non-bone cells into bone cells without cell division." [GO_REF:0000034]


id: GO:0036075
name: replacement ossification
namespace: biological_process
def:
  "Ossification that requires the replacement of a preexisting tissue prior to bone tissue formation." [GO_REF:0000034]


id: GO:0036078
name: minus-end specific microtubule depolymerization
namespace: biological_process
def:
  "The removal of tubulin heterodimers from the minus end of a microtubule." [GOC:sart, PMID:17452528]


id: GO:0036079
name: purine nucleotide-sugar transport
namespace: biological_process
def:
  "The directed movement of a purine nucleotide-sugar into, out of or within a cell. Purine nucleotide-sugars are purine nucleotides in glycosidic linkage with a monosaccharide or monosaccharide derivative." [GOC:sart, PMID:19948734]


id: GO:0036080
name: purine nucleotide-sugar transmembrane transporter activity
namespace: molecular_function
def:
  "Enables the transfer of a purine nucleotide-sugar from one side of the membrane to the other. Purine nucleotide-sugars are purine nucleotides in glycosidic linkage with a monosaccharide or monosaccharide derivative." [GOC:sart, PMID:19948734]


id: GO:0036081
name: extracellular ammonia-gated ion channel activity
namespace: molecular_function
def:
  "Enables the transmembrane transfer of an ion by a channel that opens when extracellular ammonia (NH3) has been bound by the channel complex or one of its constituent parts." [GOC:sart, PMID:19135896]


id: GO:0036082
name: extracellular phenylacetaldehyde-gated ion channel activity
namespace: molecular_function
def:
  "Enables the transmembrane transfer of an ion by a channel that opens when extracellular phenylacetaldehyde has been bound by the channel complex or one of its constituent parts." [GOC:sart, PMID:19135896]


id: GO:0036083
namespace: biological_process
name:
  positive regulation of unsaturated fatty acid biosynthetic process by positive regulation of transcription from RNA polymerase II promoter

def:
  "Any process that activates or increases the frequency, rate or extent of unsaturated fatty acid biosynthetic process by activating or increasing the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:dgf, PMID:9927444]


id: GO:0036084
name: GDP-fucose import into endoplasmic reticulum lumen
namespace: biological_process
def:
  "The directed movement of GDP-fucose into the endoplasmic reticulum lumen. GDP-fucose is a substance composed of fucose in glycosidic linkage with guanosine diphosphate." [GOC:sart, PMID:3458237]


id: GO:0036085
name: GDP-fucose import into Golgi lumen
namespace: biological_process
def:
  "The directed movement of GDP-fucose into the Golgi lumen. GDP-fucose is a substance composed of fucose in glycosidic linkage with guanosine diphosphate." [GOC:sart, PMID:3458237]


id: GO:0036086
namespace: biological_process
name:
  positive regulation of transcription from RNA polymerase II promoter in response to iron ion starvation

def:
  "Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of deprivation of iron ions." [GOC:cjk]


id: GO:0036087
name: glutathione synthase complex
namespace: cellular_component
def:
  "A protein complex composed of two or more polypeptide subunits, and which possesses glutathione synthase activity (catalysis of the reaction: L-gamma-glutamyl-L-cysteine + ATP + glycine = ADP + glutathione + 2 H(+) + phosphate). In eukaryotes, the complex is homodimeric, in E. coli glutathione synthase exists as a tetramer, and in S. pombe the complex exists as a homodimer or a heterotetramer." [GOC:al, PMID:12734194, PMID:14990577, PMID:1958212]


id: GO:0036088
name: D-serine catabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the breakdown of D-serine, the D-enantiomer of serine, i.e. (2S)-2-amino-3-hydroxypropanoic acid." [CHEBI:16523, GOC:imk]


id: GO:0036089
name: cleavage furrow formation
namespace: biological_process
def:
  "Generation of the cleavage furrow, a shallow groove in the cell surface near the old metaphase plate that marks the site of cytokinesis. This process includes the recruitment and localized activation of signals such as RhoA at the site of the future furrow to ensure that furrowing initiates at the correct site in the cell." [GOC:ans, PMID:15811947, PMID:20687468, PMID:2192590]


id: GO:0036090
name: cleavage furrow ingression
namespace: biological_process
def:
  "Advancement of the cleavage furrow from the outside of the cell inward towards the center of the cell. The cleavage furrow acts as a 'purse string' which draws tight to separate daughter cells during cytokinesis and partition the cytoplasm between the two daughter cells. The furrow ingresses until a cytoplasmic bridge is formed." [PMID:15811947, PMID:20687468]


id: GO:0036091
namespace: biological_process
name:
  positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress

def:
  "Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a stimulus indicating the organism is under oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:rn, PMID:14978214, PMID:18439143]


id: GO:0036092
name: phosphatidylinositol-3-phosphate biosynthetic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of phosphatidylinositol-3-phosphate, a phosphatidylinositol monophosphate carrying the phosphate group at the 3-position." [CHEBI:26034, GOC:al, GOC:vw]


id: GO:0036093
name: germ cell proliferation
namespace: biological_process
def:
  "The multiplication or reproduction of germ cells, reproductive cells in multicellular organisms, resulting in the expansion of a cell population." [CL:0000586, GOC:kmv]


id: GO:0036094
name: small molecule binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with a small molecule, any low molecular weight, monomeric, non-encoded molecule." [GOC:curators, GOC:pde, GOC:pm]


id: GO:0036095
namespace: biological_process
name:
  positive regulation of invasive growth in response to glucose limitation by positive regulation of transcription from RNA polymerase II promoter

def:
  "Any process that activates or increases the frequency, rate or extent of invasive growth as a result of deprivation of glucose, by activating or increasing the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:jh, PMID:14668363]


id: GO:0036096
name: obsolete 3'-5'-exoribonuclease activity involved in pre-miRNA 3'-end processing
namespace: molecular_function
def:
  "OBSOLETE. Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of an RNA molecule that contributes to forming the mature 3' end of a miRNA from a pre-miRNA." [GOC:sart, PMID:22055292]


id: GO:0036097
name: obsolete pre-miRNA 3'-end processing
namespace: biological_process
def:
  "OBSOLETE. Any process involved in forming the mature 3' end of a miRNA from a pre-miRNA." [GOC:sart, PMID:22055292]


id: GO:0036098
name: male germ-line stem cell population maintenance
namespace: biological_process
def:
  "The process by which an organism or tissue maintains a population of male germ-line stem cells." [GOC:sart, PMID:21752937]


id: GO:0036099
name: female germ-line stem cell population maintenance
namespace: biological_process
def:
  "The process by which an organism or tissue maintains a population of female germ-line stem cells." [GOC:sart]


id: GO:0036100
name: leukotriene catabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the breakdown of a leukotriene, a pharmacologically active substance derived from a polyunsaturated fatty acid, such as arachidonic acid." [CHEBI:62942, GOC:yaf]


id: GO:0036101
name: leukotriene B4 catabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the breakdown of leukotriene B4, a leukotriene composed of (6Z,8E,10E,14Z)-eicosatetraenoic acid having (5S)- and (12R)-hydroxy substituents." [CHEBI:15647, GOC:yaf, PMID:9799565, UniPathway:UPA00883]


id: GO:0036102
name: leukotriene B4 metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving leukotriene B4, a leukotriene composed of (6Z,8E,10E,14Z)-eicosatetraenoic acid having (5S)- and (12R)-hydroxy substituents." [CHEBI:15647, GOC:bf]


id: GO:0036103
name: Kdo2-lipid A metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving Kdo2-lipid A, a lipopolysaccharide (LPS) component." [CHEBI:27963, GOC:bf]


id: GO:0036104
name: Kdo2-lipid A biosynthetic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of Kdo2-lipid A, a lipopolysaccharide (LPS) component." [GOC:yaf, UniPathway:UPA00360]


id: GO:0036105
name: peroxisome membrane class-1 targeting sequence binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with a class I peroxisomal membrane targeting sequence, any of several sequences of amino acids within a protein that can act as a signal for the localization of the protein into the peroxisome membrane in a PEX19-dependent manner." [GOC:pm, PMID:14709540, PMID:17020786]


id: GO:0036106
name: peroxisome membrane class-2 targeting sequence binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with a class II peroxisomal membrane targeting sequence, any of several sequences of amino acids within a protein that can act as a signal for the localization of the protein into the peroxisome membrane in a PEX19-independent manner." [GOC:pm, PMID:14709540, PMID:17020786]


id: GO:0036107
name: 4-amino-4-deoxy-alpha-L-arabinopyranosyl undecaprenyl phosphate metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving 4-amino-4-deoxy-alpha-L-arabinopyranosyl undecaprenyl phosphate, a precursor of 4-amino-4-deoxy-L-arabinose (L-Ara4N)." [CHEBI:47039, GOC:yaf]


id: GO:0036108
name: 4-amino-4-deoxy-alpha-L-arabinopyranosyl undecaprenyl phosphate biosynthetic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of 4-amino-4-deoxy-alpha-L-arabinopyranosyl undecaprenyl phosphate, a precursor of 4-amino-4-deoxy-L-arabinose (L-Ara4N)." [CHEBI:47039, GOC:yaf, UniPathway:UPA00036]


id: GO:0036109
name: alpha-linolenic acid metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving alpha-linolenic acid, an unsaturated omega-6 fatty acid that has the molecular formula C18H32O2." [CHEBI:32387]


id: GO:0036110
name: cellular response to inositol starvation
namespace: biological_process
def:
  "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of inositol." [CHEBI:24848, GOC:al, PMID:19606215]


id: GO:0036111
name: very long-chain fatty-acyl-CoA metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving very long-chain fatty-acyl-CoAs, any derivative of coenzyme A in which the sulfhydryl group is in a thioester linkage with a medium-chain fatty-acyl group. A very long-chain fatty acid is a fatty acid which has a chain length greater than C22." [CHEBI:61910, GOC:pm]


id: GO:0036112
name: medium-chain fatty-acyl-CoA metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving medium-chain fatty-acyl-CoAs, any derivative of coenzyme A in which the sulfhydryl group is in a thioester linkage with a long-chain fatty-acyl group. A medium-chain fatty acid is a fatty acid with a chain length of between C6 and C12." [CHEBI:61907, GOC:pm]


id: GO:0036113
name: very long-chain fatty-acyl-CoA catabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the breakdown of very long-chain fatty-acyl-CoAs, any derivative of coenzyme A in which the sulfhydryl group is in a thioester linkage with a medium-chain fatty-acyl group. A very long-chain fatty acid is a fatty acid which has a chain length greater than C22." [CHEBI:61910, GOC:pm]


id: GO:0036114
name: medium-chain fatty-acyl-CoA catabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the breakdown of medium-chain fatty-acyl-CoAs, any derivative of coenzyme A in which the sulfhydryl group is in a thioester linkage with a medium-chain fatty-acyl group. A medium-chain fatty acid is a fatty acid with a chain length of between C6 and C12." [CHEBI:61907, GOC:pm]


id: GO:0036115
name: fatty-acyl-CoA catabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the breakdown of a fatty-acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with a fatty-acyl group." [CHEBI:37554]


id: GO:0036116
name: long-chain fatty-acyl-CoA catabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the breakdown of long-chain fatty-acyl-CoAs, any derivative of coenzyme A in which the sulfhydryl group is in a thioester linkage with a medium-chain fatty-acyl group. A long-chain fatty acid is a fatty acid with a chain length between C13 and C22." [CHEBI:33184, GOC:pm]


id: GO:0036117
name: hyaluranon cable
namespace: cellular_component
def:
  "A cable structure, surrounding some cell types (e.g. proximal or bronchial tubular epithelial cells), and composed of hyaluranon (HA), a ubiquitous connective tissue glycosaminoglycan." [GOC:yaf, PMID:16900089]


id: GO:0036118
name: hyaluranon cable assembly
namespace: biological_process
def:
  "A process that results in the aggregation, arrangement and bonding together of a hyaluranon cable, a cable structure, surrounding some cell types (e.g. proximal or bronchial tubular epithelial cells), and composed of hyaluranon (HA), a ubiquitous connective tissue glycosaminoglycan." [GOC:yaf, PMID:16900089]


id: GO:0036119
name: response to platelet-derived growth factor
namespace: biological_process
def:
  "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a platelet-derived growth factor stimulus." [GOC:yaf]


id: GO:0036120
name: cellular response to platelet-derived growth factor stimulus
namespace: biological_process
def:
  "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a platelet-derived growth factor stimulus." [GOC:yaf]


id: GO:0036121
name: double-stranded DNA-dependent ATP-dependent DNA helicase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: ATP + H2O = ADP + phosphate, in the presence of double-stranded DNA; drives the unwinding of a DNA helix." [GOC:kmv]


id: GO:0036122
name: BMP binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with a member of the bone morphogenetic protein (BMP) family." [GOC:BHF, PMID:9660951, PR:000000034]


id: GO:0036123
name: histone H3-K9 dimethylation
namespace: biological_process
def:
  "The modification of histone H3 by addition of two methyl groups to lysine at position 9 of the histone." [GOC:vw]


id: GO:0036124
name: histone H3-K9 trimethylation
namespace: biological_process
def:
  "The modification of histone H3 by addition of three methyl groups to lysine at position 9 of the histone." [GOC:vw]


id: GO:0036125
name: fatty acid beta-oxidation multienzyme complex
namespace: cellular_component
def:
  "A multienzyme complex possessing three kinds of enzymes that catalyze the chain reactions in the fatty acid beta-oxidation cycle, enoyl-CoA hydratase (ECH), 3-hydroxyacyl-CoA dehydrogenase (HACD), and acetyl-CoA C-acyltransferase (KACT)." [GOC:imk, PMID:12115060, PMID:16472743]


id: GO:0036126
name: sperm flagellum
namespace: cellular_component
def:
  "A microtubule-based flagellum (or cilium) that is part of a sperm, a mature male germ cell that develops from a spermatid." [GOC:cilia, GOC:sart, PMID:8441407]


id: GO:0036127
name: 3-sulfino-L-alanine binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with 3-sulfino-L-alanine (cysteine sulfinate)." [CHEBI:61085, GOC:al, PMID:8346915]


id: GO:0036128
name: CatSper complex
namespace: cellular_component
def:
  "A sperm-specific voltage-gated calcium channel that controls the intracellular calcium ion concentration and, thereby, the swimming behavior of sperm. Consists of a heteromeric tetramer surrounding a calcium ion- selective pore. May also contain additional auxiliary subunits." [GOC:sp, PMID:17478420, PMID:21224844, PMID:22354039]


id: GO:0036129
namespace: biological_process
name:
  negative regulation of transcription from RNA polymerase II promoter in response to hydrogen peroxide

def:
  "Any process that decreases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a hydrogen peroxide (H2O2) stimulus." [GOC:al]


id: GO:0036130
name: prostaglandin H2 endoperoxidase reductase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: prostaglandin H2 + NADPH + H+ -> prostaglandin F2alpha + NADP+. This reaction is the reduction of prostaglandin H2 ((5Z,13E)-(15S)-9alpha,11alpha-Epidioxy-15-hydroxyprosta-5,13-dienoate) to prostaglandin F2alpha ((5Z,13E)-(15S)-9alpha,11alpha,15-Trihydroxyprosta-5,13-dienoate)." [GOC:mw, KEGG:R02264, PMID:10622721, PMID:14979715, PMID:16475787]


id: GO:0036131
name: prostaglandin D2 11-ketoreductase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: prostaglandin D2 + H+ + NADPH -> 11-epi-prostaglandin F2alpha + NADP+." [EC:1.1.1.188, GOC:mw, KEGG:R02799, PMID:1504718, PMID:3862115]


id: GO:0036132
name: 13-prostaglandin reductase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 15-keto-prostaglandin + NAD(P)H + H+ -> 13,14-dihydro-15-keto-prostaglandin + NAD(P)+. This reaction is the reduction of 15-keto-prostaglandin." [EC:1.3.1.48, GOC:mw, KEGG:R04556, KEGG:R04557, PMID:17449869]


id: GO:0036133
name: 11-hydroxythromboxane B2 dehydrogenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: thromboxane B2 + NAD+ = 11-dehydro-thromboxane B2 + NADH + H+." [GOC:mw, KEGG:R05060, PMID:3461463, PMID:3823488, PMID:8200461]


id: GO:0036134
name: 12-hydroxyheptadecatrienoic acid synthase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: prostaglandin H2 = 12-hydroxyheptadecatrienoic acid (HHT) + malonaldehyde (MDA)." [GOC:mw, PMID:11297515]


id: GO:0036135
name: Schwann cell migration
namespace: biological_process
def:
  "The orderly movement of a Schwann cell from one site to another. A Schwann cell is a glial cell that ensheathes axons of neuron in the peripheral nervous system and is necessary for their maintainance and function." [CL:0002573, PMID:20335460]


id: GO:0036136
name: kynurenine-oxaloacetate transaminase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: L-kynurenine + 2-oxoglutarate = 4-(2-aminophenyl)-2,4-dioxobutanoate + L-aspartate." [EC:2.6.1.-, GOC:pde, PMID:15606768, PMID:4149765]


id: GO:0036137
name: kynurenine aminotransferase activity
namespace: molecular_function
def:
  "Catalysis of the transfer of an amino group from kynurenine to an acceptor, usually a 2-oxo acid." [EC:2.6.1.-, GOC:pde]


id: GO:0036138
name: peptidyl-histidine hydroxylation
namespace: biological_process
def:
  "The hydroxylation of peptidyl-histidine to form peptidyl-hydroxyhistidine." [GOC:reh, PMID:21251231]


id: GO:0036139
name: peptidyl-histidine dioxygenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: peptidyl L-histidine + 2-oxoglutarate + O2 = peptidyl hydroxy-L-histidine + succinate + CO2." [GOC:reh, PMID:21251231]


id: GO:0036140
name: peptidyl-asparagine 3-dioxygenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: peptidyl L-asparagine + 2-oxoglutarate + O2 = peptidyl 3-hydroxy-L-asparagine + succinate + CO2." [GOC:reh, PMID:12215170]


id: GO:0036141
name: L-phenylalanine-oxaloacetate transaminase activity
namespace: molecular_function
def:
  "Catalysis of the reaction L-phenylalanine + oxaloacetate = phenylpyruvate + aspartate." [GOC:pde, PMID:15606768]


id: GO:0036143
name: kringle domain binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with a kringle domain. Kringle domains are protein domains that fold into large loops stabilized by 3 disulfide linkages, and are important in protein-protein interactions with blood coagulation factors." [GOC:yaf, InterPro:IPR000001, Wikipedia:Kringle_domain]


id: GO:0036145
name: dendritic cell homeostasis
namespace: biological_process
def:
  "The process of regulating the proliferation and elimination of dendritic cells such that the total number of dendritic cells within a whole or part of an organism is stable over time in the absence of an outside stimulus." [CL:0000451, GOC:uh, PMID:12570827, PMID:19176316]


id: GO:0036146
name: cellular response to mycotoxin
namespace: biological_process
def:
  "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mycotoxin stimulus. A mycotoxin is a toxic chemical substance produced by fungi." [GOC:di, PMID:20548963]


id: GO:0036147
name: rumination
namespace: biological_process
def:
  "A digestive process in which food, usually grass or hay, is swallowed into a multi-compartmented stomach, regurgitated, chewed again, and swallowed again." [GOC:maf, Wikipedia:Rumination]


id: GO:0036148
name: phosphatidylglycerol acyl-chain remodeling
namespace: biological_process
def:
  "Remodeling the acyl chains of phosphatidylglycerol, through sequential deacylation and re-acylation reactions, to generate phosphatidylglycerol containing different types of fatty acid acyl chains." [CHEBI:17517, GOC:mw, PMID:15485873, PMID:18458083]


id: GO:0036149
name: phosphatidylinositol acyl-chain remodeling
namespace: biological_process
def:
  "Remodeling the acyl chains of phosphatidylinositol, through sequential deacylation and re-acylation reactions, to generate phosphatidylinositol containing different types of fatty acid acyl chains." [CHEBI:28874, GOC:mw, PMID:18094042, PMID:18772128]


id: GO:0036150
name: phosphatidylserine acyl-chain remodeling
namespace: biological_process
def:
  "Remodeling the acyl chains of phosphatidylserine, through sequential deacylation and re-acylation reactions, to generate phosphatidylserine containing different types of fatty acid acyl chains." [CHEBI:18303, GOC:mw, PMID:18287005, PMID:18458083]


id: GO:0036151
name: phosphatidylcholine acyl-chain remodeling
namespace: biological_process
def:
  "Remodeling the acyl chains of phosphatidylcholine, through sequential deacylation and re-acylation reactions, to generate phosphatidylcholine containing different types of fatty acid acyl chains." [CHEBI:49183, GOC:mw, PMID:18195019, PMID:18458083]


id: GO:0036152
name: phosphatidylethanolamine acyl-chain remodeling
namespace: biological_process
def:
  "Remodeling the acyl chains of phosphatidylethanolamine, through sequential deacylation and re-acylation reactions, to generate phosphatidylethanolamine containing different types of fatty acid acyl chains." [CHEBI:16038, GOC:mw, PMID:18287005, PMID:18458083]


id: GO:0036153
name: triglyceride acyl-chain remodeling
namespace: biological_process
def:
  "Remodeling the acyl chains of triacylglycerol, through sequential deacylation and re-acylation reactions, to generate triacylglycerol containing different types of fatty acid acyl chains." [CHEBI:17855, GOC:mw, PMID:15364929]


id: GO:0036154
name: diacylglycerol acyl-chain remodeling
namespace: biological_process
def:
  "Remodeling the acyl chains of diacylglycerol, through sequential deacylation and re-acylation reactions, to generate diacylglycerol containing different types of fatty acid acyl chains." [CHEBI:17855, GOC:mw, PMID:15364929]


id: GO:0036155
name: acylglycerol acyl-chain remodeling
namespace: biological_process
def:
  "Remodeling the acyl chains of an acylglycerol, through sequential deacylation and re-acylation reactions, to generate an acylglycerol containing different types of fatty acid acyl chains." [CHEBI:47778, GOC:mw, PMID:15364929]


id: GO:0036156
name: inner dynein arm
namespace: cellular_component
def:
  "Inner arm structure present on the outer doublet microtubules of ciliary and flagellar axonemes. The structure of inner dynein arms is complex and may vary within the axoneme. Inner dynein arms are heteromeric, comprising 8 different heavy chains and various subunits. Inner and outer dynein arms have different functions in the generation of microtubule-based motility." [GOC:BHF, GOC:vk, PMID:19347929, PMID:2557057, PMID:7962092]


id: GO:0036157
name: outer dynein arm
namespace: cellular_component
def:
  "Outer arm structure present on the outer doublet microtubules of ciliary and flagellar axonemes. Outer dynein arms contain 2-3 heavy chains, two or more intermediate chains and a cluster of 4-8 light chains. Inner and outer dynein arms have different functions in the generation of microtubule-based motility." [GOC:BHF, GOC:vk, PMID:2557057, PMID:6218174]


id: GO:0036158
name: outer dynein arm assembly
namespace: biological_process
def:
  "The aggregation, arrangement and bonding together of a set of components to form an axonemal dynein outer arm, an outer arm structure present on the outer doublet microtubules of ciliary and flagellar axonemes." [GOC:BHF, GOC:vk, PMID:19944400]


id: GO:0036159
name: inner dynein arm assembly
namespace: biological_process
def:
  "The aggregation, arrangement and bonding together of a set of components to form an axonemal dynein inner arm, an inner arm structure present on the outer doublet microtubules of ciliary and flagellar axonemes." [GOC:BHF, GOC:vk, PMID:19944400]


id: GO:0036160
name: melanocyte-stimulating hormone secretion
namespace: biological_process
def:
  "The regulated release of a melanocyte-stimulating hormone, any of a group of peptide hormones that are produced by cells in the intermediate lobe of the pituitary gland, and stimulate the production of melanin to increase pigmentation." [GOC:cjm, Wikipedia:Melanocyte-stimulating_hormone]


id: GO:0036161
name: calcitonin secretion
namespace: biological_process
def:
  "The regulated release of calcitonin, a peptide hormone that participates in calcium and phosphorus metabolism, from a cell." [GOC:cjm, PR:000027222]


id: GO:0036162
name: oxytocin secretion
namespace: biological_process
def:
  "The regulated release of oxytocin, a cyclic nonapeptide hormone with amino acid sequence CYIQNCPLG that also acts as a neurotransmitter in the brain, from a cell. Oxytocin is the principal uterine-contracting and milk-ejecting hormone of the posterior pituitary, and together with the neuropeptide vasopressin, is believed to influence social cognition and behavior." [CHEBI:7872, GOC:cjm, Wikipedia:Oxytocin]


id: GO:0036163
name: 3-hexaprenyl-4-hydroxy-5-methoxybenzoic acid decarboxylase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 3-hexaprenyl-4-hydroxy-5-methoxybenzoic acid -> 2-hexaprenyl-6-methoxyphenol + CO2." [GOC:mw, KEGG:R06866, PMID:620805, PMID:7028108]


id: GO:0036164
name: cell-abiotic substrate adhesion
namespace: biological_process
def:
  "The attachment of a cell to an underlying abiotic (non-living) substrate via adhesion molecules." [GOC:di]


id: GO:0036165
name: invasive growth in response to heat
namespace: biological_process
def:
  "The growth of colonies in filamentous chains of cells as a result of an increase in temperature." [GOC:di, PMID:22365851]


id: GO:0036166
name: phenotypic switching
namespace: biological_process
def:
  "A reversible switch of a cell from one cell type or form to another, at a frequency above the expected frequency for somatic mutations. Phenotypic switching begins with changes in cell morphology and altered gene expression patterns and ends when the morphology of a population of cells has reverted back to the default state, accompanied by altered expression patterns. For example, Candida albicans switches from a unicellular form to an invasive multicellular filamentous form upon infection of host tissue, and from white cells to opaque cells for sexual mating. Phenotypic switching also occurs in multicellular organisms; smooth muscle cells (SMCs) exhibit phenotypic transitions to allow rapid adaption to fluctuating environmental cues." [GOC:bf, GOC:di, PMID:12443899, PMID:22406749, PMID:8456504, Wikipedia:Phenotypic_switching]


id: GO:0036167
name: phenotypic switching in response to host
namespace: biological_process
def:
  "A reversible switch of a cell from one phenotype to another that occurs upon infection of a host or host cell. For example, Candida albicans switches from a unicellular form to an invasive multicellular filamentous form upon infection of host tissue. Phenotypic switching begins with changes in cell morphology and altered gene expression patterns and ends when the morphology of a population of cells has reverted back to the default state, accompanied by altered expression patterns." [GOC:di, PMID:16696644, Wikipedia:Phenotypic_switching]


id: GO:0036168
name: filamentous growth of a population of unicellular organisms in response to heat
namespace: biological_process
def:
  "The process in which a group of unicellular organisms grow in a threadlike, filamentous shape in response to an increase in temperature." [GOC:di, PMID:17554048]


id: GO:0036169
name: 3-methoxy-4-hydroxy-5-decaprenylbenzoic acid decarboxylase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 3-methoxy-4-hydroxy-5-decaprenylbenzoic acid -> 2-methoxy-6-decaprenylphenol + CO2." [GOC:mw, PMID:620805, PMID:7028108]


id: GO:0036170
name: filamentous growth of a population of unicellular organisms in response to starvation
namespace: biological_process
def:
  "The process in which a group of unicellular organisms grow in a threadlike, filamentous shape in response to deprivation of nourishment." [GOC:di, PMID:17554048]


id: GO:0036171
name: filamentous growth of a population of unicellular organisms in response to chemical stimulus
namespace: biological_process
def:
  "The process in which a group of unicellular organisms grow in a threadlike, filamentous shape in response to a chemical stimulus." [GOC:di, PMID:17554048]


id: GO:0036172
name: thiamine salvage
namespace: biological_process
def:
  "A process that generates thiamine (vitamin B1) from derivatives of it without de novo synthesis." [PMID:15150256, PMID:16952958]


id: GO:0036173
name: thiosulfate binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with the inorganic anion thiosulfate, a sulfur oxide that has formula O3S2." [CHEBI:16094, GOC:db, PMID:2188959]


id: GO:0036174
name: butane monooxygenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: butane + O2 + NAD(P)H + H+ = butanol + NAD(P)+ + H2O." [GOC:dh, PMID:17526838, PMID:19383682]


id: GO:0036175
name: ribonucleoside-diphosphate reductase activity, glutaredoxin disulfide as acceptor
namespace: molecular_function
def:
  "Catalysis of the reaction: 2'-deoxyribonucleoside diphosphate + glutaredoxin disulfide + H2O -> ribonucleoside diphosphate + glutaredoxin." [EC:1.17.4.1, GOC:bf, GOC:pde, PMID:7476363]


id: GO:0036176
name: response to neutral pH
namespace: biological_process
def:
  "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a neutral pH (pH close to 7) stimulus. pH is a measure of the acidity or basicity of an aqueous solution." [GOC:di, http:http\://en.wikipedia.org/wiki/PH]


id: GO:0036177
name: filamentous growth of a population of unicellular organisms in response to pH
namespace: biological_process
def:
  "The process in which a group of unicellular organisms grow in a threadlike, filamentous shape in response to a pH stimulus. pH is a measure of the acidity or basicity of an aqueous solution." [GOC:di, http://en.wikipedia.org/wiki/PH]


id: GO:0036178
name: filamentous growth of a population of unicellular organisms in response to neutral pH
namespace: biological_process
def:
  "The process in which a group of unicellular organisms grow in a threadlike, filamentous shape in response to a neutral pH (pH close to 7) stimulus." [GOC:di, PMID:6374461]


id: GO:0036179
name: osteoclast maturation
namespace: biological_process
def:
  "A developmental process, independent of morphogenetic (shape) change, that is required for an osteoclast cell to attain its fully functional state. An osteoclast is a specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue, and which typically differentiates from monocytes." [CL:0000092, GOC:pg]


id: GO:0036180
name: filamentous growth of a population of unicellular organisms in response to biotic stimulus
namespace: biological_process
def:
  "The process in which a group of unicellular organisms grow in a threadlike, filamentous shape in response to a biotic (living) stimulus." [GOC:di]


id: GO:0036181
name: protein localization to linear element
namespace: biological_process
def:
  "A cellular protein localization process in which a protein is transported to, or maintained at, a linear element. A linear element is a proteinaceous scaffold associated with S. pombe chromosomes during meiotic prophase." [GOC:mah, PMID:19756689]


id: GO:0036182
name: asperthecin metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving asperthecin, an anthraquinone pigment obtained from the mould Aspergillus nidulans." [CHEBI:64161, GOC:di]


id: GO:0036183
name: asperthecin catabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the breakdown of asperthecin, an anthraquinone pigment obtained from the mould Aspergillus nidulans." [CHEBI:64161, GOC:di]


id: GO:0036184
name: asperthecin biosynthetic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of asperthecin, an anthraquinone pigment obtained from the mould Aspergillus nidulans." [CHEBI:64161, GOC:di]


id: GO:0036185
name: 13-lipoxin reductase activity
namespace: molecular_function
def:
  "Definition: Catalysis of the reaction: 15-oxolipoxin A4 + NAD(P)H + H+ = 13,14-dihydro-15-oxolipoxin A4 + NAD(P)+." [GOC:mw, PMID:10837478]


id: GO:0036187
name: cell growth mode switching, budding to filamentous
namespace: biological_process
def:
  "The process in which a cell switches from growing as a round budding cell to growing as a filament (elongated cells attached end-to-end). An example of this is the yeast-hyphal transition of Candida albicans." [GOC:di]


id: GO:0036188
name: abieta-7,13-dien-18-al dehydrogenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: abieta-7,13-diene-18-al + H2O + NAD+ = abieta-7,13-diene-18-oate + NADH + H+." [EC:1.2.1.74]


id: GO:0036189
name: abieta-7,13-diene hydroxylase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: abieta-7,13-diene + NADPH + H+ + O2 = abieta-7,13-dien-18-ol + NADP+ + H2O." [EC:1.14.13.108]


id: GO:0036190
name: indole-2-monooxygenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: indole + NAD(P)H + H+ + O2 = indolin-2-one + NAD(P)+ + H2O." [EC:1.14.13.137]


id: GO:0036191
name: indolin-2-one monooxygenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: indolin-2-one + NAD(P)H + H+ + O2 = 3-hydroxyindolin-2-one + NAD(P)+ + H2O." [EC:1.14.13.138]


id: GO:0036192
name: 3-hydroxyindolin-2-one monooxygenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 3-hydroxyindolin-2-one + NAD(P)H + H+ + O2 = 2-hydroxy-2H-1,4-benzoxazin-3(4H)-one + NAD(P)+ + H2O." [EC:1.14.13.139]


id: GO:0036193
name: 2-hydroxy-1,4-benzoxazin-3-one monooxygenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 2-hydroxy-2H-1,4-benzoxazin-3(4H)-one + NAD(P)H + H+ + O2 = 2,4-dihydroxy-2H-1,4-benzoxazin-3(4H)-one + NAD(P)+ + H2O." [EC:1.14.13.140]


id: GO:0036194
name: muscle cell projection
namespace: cellular_component
def:
  "A prolongation or process extending from a muscle cell. A muscle cell is a mature contractile cell, commonly known as a myocyte. This cell has as part of its cytoplasm myofibrils organized in various patterns." [CL:0000187, GOC:kmv, PMID:15930100, PMID:22464329]


id: GO:0036195
name: muscle cell projection membrane
namespace: cellular_component
def:
  "The portion of the plasma membrane surrounding a muscle cell projection." [CL:0000187, GOC:kmv, PMID:15930100, PMID:22464329]


id: GO:0036196
name: zymosterol metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving zymosterol, (5alpha-cholesta-8,24-dien-3beta-ol)." [CHEBI:18252, GOC:yaf]


id: GO:0036197
name: zymosterol biosynthetic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of zymosterol, (5alpha-cholesta-8,24-dien-3beta-ol)." [CHEBI:18252, GOC:yaf, MetaCyc:PWY-6074]


id: GO:0036198
name: dTMP salvage
namespace: biological_process
def:
  "Any process which produces dTMP, deoxyribosylthymine monophosphate (2'-deoxyribosylthymine 5'-phosphate) without de novo synthesis." [GOC:yaf, UniPathway:UPA00578]


id: GO:0036199
name: cholest-4-en-3-one 26-monooxygenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: cholest-4-en-3-one + NADH + H+ + O2 = 26-hydroxycholest-4-en-3-one + NAD+ + H2O. This reaction involves the hydroxylation of the C26 carbon, followed by oxidation of the alcohol to the carboxylic acid via the aldehyde intermediate." [EC:1.14.13.141]


id: GO:0036200
name: 3-ketosteroid 9-alpha-monooxygenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: androsta-1,4-diene-3,17-dione + NADH + H+ + O2 = 9alpha-hydroxyandrosta-1,4-diene-3,17-dione + NAD+ + H2O." [EC:1.14.13.142]


id: GO:0036201
name: ent-isokaurene C2-hydroxylase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: ent-isokaurene + O2 + NADPH + H+ = ent-2alpha-hydroxyisokaurene + H2O + NADP+." [EC:1.14.13.143]


id: GO:0036202
name: ent-cassa-12,15-diene 11-hydroxylase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: ent-cassa-12,15-diene + O2 + NADPH + H+ = ent-11beta-hydroxycassa-12,15-diene + NADP+ + H2O." [EC:1.14.13.145]


id: GO:0036203
name: taxoid 14-beta-hydroxylase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 10beta-hydroxytaxa-4(20),11-dien-5alpha-yl acetate + O2 + NADPH + H+ = 10beta,14beta-dihydroxytaxa-4(20),11-dien-5alpha-yl acetate + NADP+ + H2O." [EC:1.14.13.146]


id: GO:0036204
name: abieta-7,13-dien-18-ol hydroxylase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: abieta-7,13-dien-18-ol + NADPH + H+ + O2 = abieta-7,13-dien-18-al + NADP+ + 2 H2O. This is a two step reaction. The first step is: abieta-7,13-dien-18-ol + NADPH + H+ + O2 = abieta-7,13-dien-18,18-diol + + NADP+ + H2O. The second step is a spontaneous reaction: abieta-7,13-dien-18,18-diol = abieta-7,13-dien-18-al + H2O." [EC:1.14.13.109]


id: GO:0036205
name: histone catabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the breakdown of a histone protein by individual cells." [GOC:krc]


id: GO:0036206
name: regulation of histone gene expression
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of expression of a histone-encoding gene. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein." [GOC:bf, GOC:krc]


id: GO:0036207
name: positive regulation of histone gene expression
namespace: biological_process
def:
  "Any process that increases the frequency, rate or extent of expression of a histone-encoding gene. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein." [GOC:bf, GOC:krc]


id: GO:0036208
name: negative regulation of histone gene expression
namespace: biological_process
def:
  "Any process that decreases the frequency, rate or extent of expression of a histone-encoding gene. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein." [GOC:bf, GOC:krc]


id: GO:0036209
name: 9beta-pimara-7,15-diene oxidase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 9beta-pimara-7,15-diene + 3 O2 + 3 NADPH + 3 H+ = 9beta-pimara-7,15-dien-19-oate + 3 NADP+ + 4 H2O. This is a three-step reaction: (a) 9beta-pimara-7,15-diene + O2 + NADPH + H+ = 9beta-pimara-7,15-dien-19-ol + NADP+ + H2O, (b) 9beta-pimara-7,15-dien-19-ol + O2 + NADPH + H+ = 9neta-pimara-7,15-dien-19-al + NADP+ + 2 H2O, (c) 9beta-pimara-7,15-dien-19-al + O2 + NADPH + H+ = 9beta-pimara-7,15-dien-19-oate + NADP+ + H2O." [EC:1.14.13.144]


id: GO:0036210
name: protein modification process in other organism
namespace: biological_process
def:
  "The covalent alteration performed by one organism of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications) in another organism. Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification)." [GOC:bf, GOC:jl]


id: GO:0036211
name: protein modification process
namespace: biological_process
def:
  "The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification)." [GOC:bf, GOC:jl]


id: GO:0036212
name: contractile ring maintenance
namespace: biological_process
def:
  "The process in which the contractile ring is maintained, typically in response to an internal or external cue." [GOC:mah, GOC:vw]


id: GO:0036214
name: contractile ring localization
namespace: biological_process
def:
  "The process in which a contractile ring is assembled and/or maintained in a specific location." [GOC:mah, GOC:vw]


id: GO:0036215
name: response to stem cell factor
namespace: biological_process
def:
  "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stem cell factor (SCF) stimulus." [GOC:uh, PR:000009345]


id: GO:0036216
name: cellular response to stem cell factor stimulus
namespace: biological_process
def:
  "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stem cell factor (SCF) stimulus." [GOC:uh, PMID:18787413, PMID:7520444, PR:000009345]


id: GO:0036217
name: dGTP diphosphatase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: dGTP + H2O = dGMP + diphosphate." [GOC:dgf, KEGG:R01855, PMID:17090528, PMID:22531138]


id: GO:0036220
name: ITP diphosphatase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: ITP + H2O = IMP + diphosphate." [GOC:dgf, KEGG:R00720, PMID:17899088, PMID:22531138]


id: GO:0036222
name: XTP diphosphatase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: XTP + H2O = xanthosine 5'-phosphate + diphosphate." [GOC:dgf, PMID:22531138]


id: GO:0036223
name: cellular response to adenine starvation
namespace: biological_process
def:
  "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of adenine." [CHEBI:16708, GOC:ai]


id: GO:0036224
name: pairing center
namespace: cellular_component
def:
  "A special chromosome region located towards one end of a chromosome that contains dispersed copies of short, repetitive DNA sequences and functions as a cis-acting element essential for presynaptic homologous chromosome pairing and chromosome-nuclear envelope attachment." [GOC:kmv, PMID:18597662]


id: GO:0036225
name: cellular response to vitamin B1 starvation
namespace: biological_process
def:
  "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of vitamin B1 (also called thiamin and thiamine)." [CHEBI:18385, GOC:al]


id: GO:0036226
name: obsolete mitotic cell cycle arrest in response to glucose starvation
namespace: biological_process
def:
  "OBSOLETE. The process in which the mitotic cell cycle is halted during one of the normal phases (G1, S, G2, M) as a result of deprivation of glucose." [GOC:al, GOC:mah, PMID:958201]


id: GO:0036227
name: mitotic G2 cell cycle arrest in response to glucose starvation
namespace: biological_process
def:
  "The process in which the mitotic cell cycle is halted during G2 phase as a result of deprivation of glucose." [GOC:al, GOC:mah, GOC:mtg_cell_cycle, PMID:958201]


id: GO:0036228
name: protein targeting to nuclear inner membrane
namespace: biological_process
def:
  "The process of targeting a protein to, and inserting it into, the nuclear inner membrane; usually uses signals contained within the protein." [GOC:dgf, PMID:16929305]


id: GO:0036229
name: L-glutamine import
namespace: biological_process
def:
  "The directed movement of L-glutamine, the L-enantiomer of glutamine, into a cell or organelle." [CHEBI:18050, GOC:al]


id: GO:0036230
name: granulocyte activation
namespace: biological_process
def:
  "The change in morphology and behavior of a granulocyte resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor." [CL:0000094, GOC:nhn]


id: GO:0036231
name: L-threonine import
namespace: biological_process
def:
  "The directed movement of L-threonine, the L-enantiomer of threonine, into a cell or organelle." [CHEBI:16857, GOC:al]


id: GO:0036232
name: L-tyrosine import
namespace: biological_process
def:
  "The directed movement of L-tyrosine, the L-enantiomer of tyrosine, into a cell or organelle." [CHEBI:17895, GOC:al]


id: GO:0036234
name: deglucuronidation
namespace: biological_process
def:
  "The removal of glucuronic acid from a conjugated substrate." [GOC:BHF, GOC:vk, PMID:22294686, PMID:8560473]


id: GO:0036236
name: acyl glucuronidation
namespace: biological_process
def:
  "The modification of an substrate by the conjugation of glucuronic acid to form an acyl-glucuronide (also called an acyl-glucuronoside)." [GOC:BHF, GOC:vk, PMID:12485951, PMID:22294686]


id: GO:0036237
name: acyl-glucuronidase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: an acyl-glucuronoside + H2O = an alcohol + D-glucuronate." [GOC:BHF, GOC:vk, PMID:22294686]


id: GO:0036238
name: gallate dioxygenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: gallate + O2 = (1E)-4-oxobut-1-ene-1,2,4-tricarboxylate." [EC:1.13.11.57, PMID:16030014]


id: GO:0036239
name: taxoid 7beta-hydroxylase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: taxusin + O2 + NADPH + H+ = 7beta-hydroxytaxusin + NADP+ + H2O." [EC:1.14.13.147]


id: GO:0036240
name: septal periplasm
namespace: cellular_component
def:
  "The region between the plasma membrane and the cell wall, as found in organisms such as filamentous fungi." [GOC:di, PMID:21564341]


id: GO:0036241
name: glutamate catabolic process to 4-hydroxybutyrate
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the breakdown of glutamate into 4-hydroxybutyrate." [GOC:bf, MetaCyc:PWY-4321]


id: GO:0036242
name: glutamate catabolic process to succinate via 2-oxoglutarate-dependent GABA-transaminase activity
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the breakdown of glutamate into succinate, that includes the conversion of 4-aminobutyrate to succinate semialdehyde by the 2-oxoglutarate-dependent gamma aminobutyrate (GABA) transaminase." [GOC:bf, MetaCyc:PWY-4321]


id: GO:0036243
name: succinate-semialdehyde dehydrogenase (NADP+) activity
namespace: molecular_function
def:
  "Catalysis of the reaction: succinate semialdehyde + NADP+ + H2O = succinate + NADPH + 2 H+." [EC:1.2.1.79, GOC:bf]


id: GO:0036244
name: cellular response to neutral pH
namespace: biological_process
def:
  "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a neutral pH (pH close to 7) stimulus. pH is a measure of the acidity or basicity of an aqueous solution." [GOC:di, http://en.wikipedia.org/wiki/PH]


id: GO:0036245
name: cellular response to menadione
namespace: biological_process
def:
  "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a menadione stimulus. Menadione (also called vitamin K3) is a naphthoquinone having a methyl substituent at the 2-position." [CHEBI:28869, GOC:al]


id: GO:0036246
name: phytochelatin 2 import into vacuole
namespace: biological_process
def:
  "The directed movement of phytochelatin 2 (PC2) into the vacuole. Phytochelatin 2 is a glutathione-related peptide composed of (gamma-Glu-Cys)n-Gly where n=2, and where the Glu and Cys residues are linked through a gamma-carboxylamide bond." [CHEBI:64744, GOC:al, PMID:19001374]


id: GO:0036247
name: phytochelatin 3 import into vacuole
namespace: biological_process
def:
  "The directed movement of phytochelatin 3 (PC3) into the vacuole. Phytochelatin 3 is a glutathione-related peptide composed of (gamma-Glu-Cys)n-Gly where n=3, and where the Glu and Cys residues are linked through a gamma-carboxylamide bond." [CHEBI:64745, GOC:al, PMID:19001374]


id: GO:0036248
name: phytochelatin 4 import into vacuole
namespace: biological_process
def:
  "The directed movement of phytochelatin 4 (PC4) into the vacuole. Phytochelatin 4 is a glutathione-related peptide composed of (gamma-Glu-Cys)n-Gly where n=4, and where the Glu and Cys residues are linked through a gamma-carboxylamide bond." [CHEBI:64747, GOC:al, PMID:19001374]


id: GO:0036250
name: peroxisome transport along microtubule
namespace: biological_process
def:
  "The directed movement of a peroxisome along a microtubule, mediated by motor proteins." [GOC:pm, PMID:21525035]


id: GO:0036251
name: positive regulation of transcription from RNA polymerase II promoter in response to salt stress
namespace: biological_process
def:
  "Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a stimulus indicating the organism is under salt stress. The stress is usually an increase or decrease in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment." [GOC:al]


id: GO:0036252
name: positive regulation of transcription from RNA polymerase II promoter in response to menadione
namespace: biological_process
def:
  "Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a menadione stimulus. Menadione (also called vitamin K3) is a naphthoquinone having a methyl substituent at the 2-position." [CHEBI:28869, GOC:al]


id: GO:0036253
name: response to amiloride
namespace: biological_process
def:
  "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amiloride stimulus." [CHEBI:2639, GOC:mah]


id: GO:0036254
name: cellular response to amiloride
namespace: biological_process
def:
  "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amiloride stimulus." [CHEBI:2639, GOC:mah]


id: GO:0036255
name: response to methylamine
namespace: biological_process
def:
  "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methylamine stimulus." [CHEBI:16830, GOC:mah]


id: GO:0036256
name: cellular response to methylamine
namespace: biological_process
def:
  "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methylamine stimulus." [CHEBI:16830, GOC:mah]


id: GO:0036257
name: multivesicular body organization
namespace: biological_process
def:
  "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a multivesicular body. A multivesicular body is a type of late endosome in which regions of the limiting endosomal membrane invaginate to form internal vesicles; membrane proteins that enter the internal vesicles are sequestered from the cytoplasm." [GOC:sart, PMID:11566881]


id: GO:0036258
name: multivesicular body assembly
namespace: biological_process
def:
  "The aggregation, arrangement and bonding together of a set of components to form a multivesicular body, a type of late endosome in which regions of the limiting endosomal membrane invaginate to form internal vesicles; membrane proteins that enter the internal vesicles are sequestered from the cytoplasm." [GOC:sart, PMID:11566881, PMID:19571114]


id: GO:0036259
name: aerobic raffinose catabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the breakdown of raffinose that occur in the presence of oxygen." [GOC:al, PMID:10082789]


id: GO:0036260
name: RNA capping
namespace: biological_process
def:
  "The sequence of enzymatic reactions by which a cap structure is added to the 5' end of a nascent RNA polymerase II transcript. All RNA polymerase II transcripts receive a 7-methyl-G cap. Then for (at least) small nuclear RNAs (snRNAs) and small nucleolar RNAs (snoRNAs), the7-methyl-G cap is hypermethylated to become a 2,2,7-trimethylguanosine (TMG) cap." [GOC:bf, GOC:krc, GOC:mah, PMID:18775984]


id: GO:0036261
name: 7-methylguanosine cap hypermethylation
namespace: biological_process
def:
  "Hypermethylation of the 7-(mono)methylguanosine (m(7)G) cap structure at the 2' position of the guanosine residue to convert a mono-methylated cap to a 2,2,7-trimethylguanosine cap structure. This type of cap modification occurs on small nuclear RNAs (snRNAs) and small nucleolar RNAs (snoRNAs) and is dependent on prior guanine-N7 methylation." [GOC:bf, GOC:BHF, GOC:krc, GOC:mah, GOC:rl, PMID:11983179, PMID:18775984]


id: GO:0036262
name: granulysin production
namespace: biological_process
def:
  "The appearance of granulysin due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:rv, PR:000008119]


id: GO:0036263
name: L-DOPA monooxygenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: L-DOPA + O2 = ? + H2O. This reaction catalyzes the oxygenation of the dopamine precursor L-DOPA, to the corresponding o-quinone." [GOC:sart, PMID:22120533]


id: GO:0036264
name: dopamine monooxygenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: dopamine + O2 = ? + H2O. This reaction catalyzes the oxygenation of dopamine to the corresponding o-quinone." [GOC:sart, PMID:22120533]


id: GO:0036265
name: RNA (guanine-N7)-methylation
namespace: biological_process
def:
  "The addition of a methyl group to the N7 atom in the base portion of a guanine nucleotide residue in an RNA molecule." [GOC:BHF, GOC:rl]


id: GO:0036266
name: Cdc48p-Npl4p-Vms1p AAA ATPase complex
namespace: cellular_component
def:
  "A multiprotein ATPase complex involved in the release of polyubiquitinated proteins, including those damaged by oxidative stress, from the outer mitochondria membrane into the cytoplasm where they are presented to the proteasome for proteolysis, a process also referred to as mitochondria-associated degradation (MAD). In budding yeast, this complex includes Cdc48p, Npl4p and Vms1p." [GOC:rn, PMID:21070972, PMID:21936843]


id: GO:0036268
name: swimming
namespace: biological_process
def:
  "Self-propelled movement of an organism from one location to another through water, often by means of active fin movement." [GOC:cvs, PMID:22459995]


id: GO:0036269
name: swimming behavior
namespace: biological_process
def:
  "The response to external or internal stimuli that results in the locomotory process of swimming. Swimming is the self-propelled movement of an organism through the water." [GOC:cvs, PMID:16764679]


id: GO:0036270
name: response to diuretic
namespace: biological_process
def:
  "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a diuretic stimulus. A diuretic is an agent that promotes the excretion of urine through its effects on kidney function." [CHEBI:35498, GOC:hp]


id: GO:0036271
name: response to methylphenidate
namespace: biological_process
def:
  "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methylphenidate stimulus." [CHEBI:6887, GOC:hp, Wikipedia:Methylphenidate]


id: GO:0036272
name: response to gemcitabine
namespace: biological_process
def:
  "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gemcitabine stimulus. Gemcitabine is a 2'-deoxycytidine having geminal fluoro substituents in the 2'-position, and is used as a drug in the treatment of various carcinomas." [CHEBI:175901, GOC:hp, Wikipedia:Gemcitabine]


id: GO:0036273
name: response to statin
namespace: biological_process
def:
  "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a statin stimulus. Statins are organooxygen compounds whose structure is related to compactin (mevastatin) and which may be used as an anticholesteremic drug due its EC 1.1.1.34/EC 1.1.1.88 (hydroxymethylglutaryl-CoA reductase) inhibitory properties." [GOC:hp]


id: GO:0036274
name: response to lapatinib
namespace: biological_process
def:
  "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lapatinib stimulus." [CHEBI:49603, GOC:hp]


id: GO:0036275
name: response to 5-fluorouracil
namespace: biological_process
def:
  "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 5-fluorouracil stimulus." [CHEBI:46345, GOC:hb]


id: GO:0036276
name: response to antidepressant
namespace: biological_process
def:
  "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antidepressant stimulus, a mood-stimulating drug." [CHEBI:35469, GOC:hp]


id: GO:0036277
name: response to anticonvulsant
namespace: biological_process
def:
  "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an anticonvulsant stimulus, a drug used to prevent seizures or reduce their severity." [CHEBI:35623, GOC:hp]


id: GO:0036278
namespace: biological_process
name:
  positive regulation of transcription from RNA polymerase II promoter in response to nitrogen starvation

def:
  "Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a deprivation of nitrogen." [GOC:al, PMID:21118960]


id: GO:0036279
name: positive regulation of protein export from nucleus in response to glucose starvation
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of directed movement of proteins from the nucleus into the cytoplasm in response to deprivation of glucose." [GOC:al, PMID:3541942]


id: GO:0036280
name: cellular response to L-canavanine
namespace: biological_process
def:
  "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a L-canavanine stimulus. L-canavanine is L-homoserine substituted at oxygen with a guanidino (carbamimidamido) group." [CHEBI:609827, GOC:al]


id: GO:0036281
name: coflocculation
namespace: biological_process
def:
  "The non-sexual aggregation between single-celled organisms of different species." [GOC:al, PMID:11472912, PMID:11693916]


id: GO:0036282
name: coflocculation via protein-carbohydrate interaction
namespace: biological_process
def:
  "The non-sexual aggregation between single-celled organisms of different species mediated by interaction of a protein in one species and a carbohydrate in the other species. For example, coflocculation between S. pombe and E. coli is mediated by mannose residues in the yeast cell wall interacting with lectin protein in E. coli cell projections." [GOC:al, PMID:11472912, PMID:11693916]


id: GO:0036283
name: positive regulation of transcription factor import into nucleus in response to oxidative stress
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of the movement of a transcription factor from the cytoplasm to the nucleus under conditions of oxidative stress." [GOC:al, PMID:9585505]


id: GO:0036284
name: tubulobulbar complex
namespace: cellular_component
def:
  "Actin-based structures involved in establishing close contact between Sertoli-Sertoli cells or Sertoli-spermatids in the seminiferous tubules of the testes." [GOC:sl, PMID:22510523]


id: GO:0036285
name: SAGA complex assembly
namespace: biological_process
def:
  "The aggregation, arrangement and bonding together of a set of components to form a SAGA complex, a SAGA-type histone acetyltransferase complex that contains Spt8 (in budding yeast) or a homolog thereof." [GOC:mah, PMID:10637607, PMID:22456315]


id: GO:0036286
name: eisosome filament
namespace: cellular_component
def:
  "A filamentous cortical structure formed, in S. pombe, by the eisosome component Pil1." [GOC:vw, PMID:21900489, PMID:23722945]


id: GO:0036287
name: response to iloperidone
namespace: biological_process
def:
  "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an iloperidone stimulus." [CHEBI:113949, GOC:hp]


id: GO:0036288
name: response to ximelagatran
namespace: biological_process
def:
  "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ximelagatran stimulus." [CHEBI:578003, GOC:hp]


id: GO:0036289
name: peptidyl-serine autophosphorylation
namespace: biological_process
def:
  "The phosphorylation by a protein of one or more of its own serine amino acid residues, or a serine residue on an identical protein." [GOC:pm]


id: GO:0036290
name: protein trans-autophosphorylation
namespace: biological_process
def:
  "The phosphorylation by a protein of a residue on an identical protein. For example, phosphorylation by the other kinase within a homodimer." [GOC:jsg, PMID:20516151]


id: GO:0036291
name: protein cis-autophosphorylation
namespace: biological_process
def:
  "The phosphorylation by a protein of one or more of its own amino acid residues." [GOC:jsg, PMID:9201908]


id: GO:0036292
name: DNA rewinding
namespace: biological_process
def:
  "The process in which interchain hydrogen bonds between two single-stranded DNA (ssDNA) are reformed to regenerate double-stranded DNA (dsDNA). ssDNA is often bound and stabilized by proteins such as replication protein A (RPA) to form ssDNA bubbles. The bubbles can be rewound by ATP-dependent motors to reform base pairs between strands and thus dsDNA." [PMID:21078962, PMID:22704558, PMID:22705370, PMID:22759634]


id: GO:0036293
name: response to decreased oxygen levels
namespace: biological_process
def:
  "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting a decline in the level of oxygen." [GOC:al]


id: GO:0036294
name: cellular response to decreased oxygen levels
namespace: biological_process
def:
  "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting a decline in the level of oxygen." [GOC:al]


id: GO:0036295
name: cellular response to increased oxygen levels
namespace: biological_process
def:
  "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting an increase in the level of oxygen." [GOC:al]


id: GO:0036296
name: response to increased oxygen levels
namespace: biological_process
def:
  "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting an increase in the level of oxygen." [GOC:al]


id: GO:0036297
name: interstrand cross-link repair
namespace: biological_process
def:
  "Removal of a DNA interstrand crosslink (a covalent attachment of DNA bases on opposite strands of the DNA) and restoration of the DNA. DNA interstrand crosslinks occur when both strands of duplex DNA are covalently tethered together (e.g. by an exogenous or endogenous agent), thus preventing the strand unwinding necessary for essential DNA functions such as transcription and replication." [GOC:vw, PMID:16464006, PMID:22064477]


id: GO:0036298
name: recombinational interstrand cross-link repair
namespace: biological_process
def:
  "Removal of a DNA interstrand crosslink (a covalent attachment of DNA bases on opposite strands of the DNA) and restoration of the DNA by a mechanism that involves the exchange, reciprocal or nonreciprocal, of genetic material between the broken DNA molecule and a homologous region of DNA." [GOC:vw, PMID:20658649]


id: GO:0036299
name: non-recombinational interstrand cross-link repair
namespace: biological_process
def:
  "Removal of a DNA interstrand crosslink (a covalent attachment of DNA bases on opposite strands of the DNA) and restoration of the DNA by a mechanism that does not involve homologous DNA recombination." [GOC:vw, PMID:11154259, PMID:22064477]


id: GO:0036300
name: B cell receptor internalization
namespace: biological_process
def:
  "A receptor-mediated endocytosis process that results in the movement of a B cell receptor from the plasma membrane to the inside of the cell." [GOC:add, GOC:amm]


id: GO:0036301
name: macrophage colony-stimulating factor production
namespace: biological_process
def:
  "The appearance of macrophage colony-stimulating factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:BHF, GOC:vk]


id: GO:0036302
name: atrioventricular canal development
namespace: biological_process
def:
  "The progression of the atrioventricular canal over time, from its formation to the mature structure. The atrioventricular canal is the part of the heart connecting the atrium to the cardiac ventricle." [GOC:BHF, GOC:gr, PMID:14701881, UBERON:0002087, ZFA:0001315]


id: GO:0036303
name: lymph vessel morphogenesis
namespace: biological_process
def:
  "The process in which the anatomical structures of lymph vessels are generated and organized. The lymph vessel is the vasculature carrying lymph." [GOC:BHF, GOC:gr, PMID:18093989]


id: GO:0036304
name: umbilical cord morphogenesis
namespace: biological_process
def:
  "The process in which the anatomical structures of the umbilical cord are generated and organized. The umbilical cord is an organ or embryonic origin consisting of the 2 umbilical arteries and the one umbilical vein. The umbilical cord connects the cardiovascular system of the fetus to the mother via the placenta." [GOC:BHF, GOC:gr, PMID:15107403]


id: GO:0036305
name: ameloblast differentiation
namespace: biological_process
def:
  "The process in which a relatively unspecialized cell acquires specialized features of an ameloblast, a cylindrical epithelial cell in the innermost layer of the enamel organ." [CL:0000059]


id: GO:0036306
name: embryonic heart tube elongation
namespace: biological_process
def:
  "The developmental growth that results in the increase in length of the embryonic heart tube. The embryonic heart tube is an epithelial tube that will give rise to the mature heart." [GOC:BHF, GOC:gr, PMID:15901664]


id: GO:0036307
name: 23S rRNA (adenine(2030)-N(6))-methyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: S-adenosyl-L-methionine + adenine(2030) in 23S rRNA = S-adenosyl-L-homocysteine + rRNA containing N(6)-methyladenine(2030) in 23S rRNA." [GOC:imk, PMID:22847818]


id: GO:0036308
name: 16S rRNA (guanine(1516)-N(2))-methyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: S-adenosyl-L-methionine + guanosine(1516) in 16S rRNA = N(2)-methylguanosine(1516) in 16S rRNA + S-adenosyl-L-homocysteine." [GOC:imk, PMID:22079366]


id: GO:0036309
name: protein localization to M-band
namespace: biological_process
def:
  "Any process in which a protein is transported to, and/or maintained in, the M band. The M band is the midline of aligned thick filaments in a sarcomere." [GOC:BHF, GOC:rl, PMID:18782775]


id: GO:0036310
name: annealing helicase activity
namespace: molecular_function
def:
  "Catalysis of the ATP-dependent rewinding of single-stranded DNA (ssDNA) to reform base pairs between strands. Often acts on ssDNA bubbles bound by replication protein A (RPA)." [GOC:bf, GOC:sp, PMID:21078962, PMID:22704558, PMID:22705370, PMID:22759634]


id: GO:0036311
name: chitin disaccharide deacetylase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 2-(acetylamino)-4-O-[2-(acetylamino)-2-deoxy-beta-D-glucopyranosyl]-2-deoxy-beta-D-glucopyranose + H2O = 2-(acetylamino)-4-O-(2-amino-2-deoxy-beta-D-glucopyranosyl)-2-deoxy-beta-D-glucopyranose + acetate." [EC:3.5.1.105, GOC:imk]


id: GO:0036312
name: phosphatidylinositol 3-kinase regulatory subunit binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with a regulatory subunit of phosphatidylinositol 3-kinase. The regulatory subunit associates with the catalytic subunit to regulate both its activity and subcellular location." [GOC:bf, PMID:20505341]


id: GO:0036313
name: phosphatidylinositol 3-kinase catalytic subunit binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with the catalytic subunit of a phosphatidylinositol 3-kinase. The catalytic subunit catalyzes the addition of a phosphate group to an inositol lipid at the 3' position of the inositol ring." [GOC:bf, PMID:17475214]


id: GO:0036314
name: response to sterol
namespace: biological_process
def:
  "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a sterol stimulus." [CHEBI:15889, GOC:bf]


id: GO:0036315
name: cellular response to sterol
namespace: biological_process
def:
  "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a sterol stimulus." [CHEBI:15889, GOC:bf]


id: GO:0036316
name: SREBP-SCAP complex retention in endoplasmic reticulum
namespace: biological_process
def:
  "Any process in which the SREBP-SCAP complex is maintained in the endoplasmic reticulum and prevented from moving elsewhere. The SREBP-SCAP complex is formed by the association of sterol regulatory element binding protein (SREBP) and SREBP-cleavage-activating protein (SCAP). In the absence of sterols, the SREBP-SCAP complex is packaged into COPII vesicles and travels to the Golgi apparatus to be processed. In the presence of sterols, the complex binds ER-resident proteins such as INSIG, which retain the complex in the ER." [GOC:bf, PMID:16525117]


id: GO:0036317
name: tyrosyl-RNA phosphodiesterase activity
namespace: molecular_function
def:
  "Catalysis of the hydrolysis of a 5' tyrosyl-RNA phosphodiester bond between a protein and RNA. In picornaviruses, this covalent bond connects VPg, a viral-encoded protein essential for RNA replication, to the 5' end of all nascent picornavirus genomes; it is cleaved from viral RNA prior to its engaging in protein synthesis." [GOC:bf, GOC:sp, PMID:21408223, PMID:22908287]


id: GO:0036318
name: peptide pheromone receptor activity
namespace: molecular_function
def:
  "Combining with a peptide pheromone, and transmitting the signal across the membrane to initiate a change in cell activity." [CHEBI:38579, GOC:al]


id: GO:0036319
name: mating-type M-factor pheromone receptor activity
namespace: molecular_function
def:
  "Combining with the mating-type peptide pheromone M-factor and transmitting the signal across the membrane to initiate a change in cell activity. M-factor is a nine-membered oligopeptide that consists of tyrosyl, threonyl, prolyl, lysyl, valyl, prolyl, tyrosyl, methionyl and methyl S-farnesylcysteinate residues joined in sequence, and is a peptide pheromone released by Schizosaccharomyces pombe cells of the cellular mating type Minus." [CHEBI:64120, GOC:al]


id: GO:0036320
name: mating-type P-factor pheromone receptor activity
namespace: molecular_function
def:
  "Combining with the mating-type peptide pheromone P-factor and transmitting the signal across the membrane to initiate a change in cell activity. P-factor is a polypeptide of 23 residues, with the sequence Thr-Tyr-Ala-Asp-Phe-Leu-Arg-Ala-Tyr-Gln-Ser-Trp-Asn-Thr-Phe-Val-Asn-Pro-Asp-Arg-Pro-Asn-Leu, and is a peptide pheromone released by Schizosaccharomyces pombe cells of the cellular mating type Plus." [CHEBI:64120, GOC:al]


id: GO:0036321
name: ghrelin secretion
namespace: biological_process
def:
  "The regulated release of ghrelin from a cell. Ghrelin is a 28 amino acid hunger-stimulating peptide hormone." [GOC:cjm, PMID:14610293, Wikipedia:Ghrelin]


id: GO:0036322
name: pancreatic polypeptide secretion
namespace: biological_process
def:
  "The regulated release of pancreatic polypeptide (PP) from a cell. Pancreatic polypeptide is a 36 amino acid polypeptide secreted by islets of Langerhans cells in the pancreas." [GOC:cjm, PMID:12730894, Wikipedia:Pancreatic_polypeptide]


id: GO:0036323
name: vascular endothelial growth factor receptor-1 signaling pathway
namespace: biological_process
def:
  "Any series of molecular signals initiated by the binding of an extracellular ligand to a vascular endothelial growth factor receptor-1 (VEGFR-1) located on the surface of the receiving cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:uh, PR:000007563, Wikipedia:FLT1, Wikipedia:VEGF_receptors]


id: GO:0036324
name: vascular endothelial growth factor receptor-2 signaling pathway
namespace: biological_process
def:
  "Any series of molecular signals initiated by the binding of an extracellular ligand to a vascular endothelial growth factor receptor-2 (VEGFR-2) located on the surface of the receiving cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:uh, PMID:12967471, PR:000002112, Wikipedia:Kinase_insert_domain_receptor, Wikipedia:VEGF_receptors]


id: GO:0036325
name: vascular endothelial growth factor receptor-3 signaling pathway
namespace: biological_process
def:
  "Any series of molecular signals initiated by the binding of an extracellular ligand to a vascular endothelial growth factor receptor-3 (VEGFR-3) located on the surface of the receiving cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:uh, PR:000007565, Wikipedia:VEGF_receptors, Wikipedia:VEGFR3]


id: GO:0036326
name: VEGF-A-activated receptor activity
namespace: molecular_function
def:
  "Combining with vascular endothelial growth factor A (VEGF-A) and transmitting the signal across the plasma membrane to initiate a change in cell activity." [GOC:bf, GOC:signaling, PR:000017284, Wikipedia:VEGF-A]


id: GO:0036327
name: VEGF-B-activated receptor activity
namespace: molecular_function
def:
  "Combining with vascular endothelial growth factor B (VEGF-B) and transmitting the signal across the plasma membrane to initiate a change in cell activity." [GOC:bf, GOC:signaling, PR:000003096, Wikipedia:VEGF-B]


id: GO:0036328
name: VEGF-C-activated receptor activity
namespace: molecular_function
def:
  "Combining with vascular endothelial growth factor C (VEGF-C) and transmitting the signal across the plasma membrane to initiate a change in cell activity." [GOC:bf, GOC:signaling, PR:000017285, Wikipedia:VEGF-C]


id: GO:0036329
name: VEGF-D-activated receptor activity
namespace: molecular_function
def:
  "Combining with vascular endothelial growth factor D (VEGF-D) and transmitting the signal across the plasma membrane to initiate a change in cell activity." [GOC:bf, GOC:signaling, PR:000007520, Wikipedia:VEGF-D]


id: GO:0036330
name: VEGF-E-activated receptor activity
namespace: molecular_function
def:
  "Combining with vascular endothelial growth factor E (VEGF-E) and transmitting the signal across the plasma membrane to initiate a change in cell activity." [GOC:bf, GOC:signaling, PMID:19909239]


id: GO:0036331
name: avascular cornea development in camera-type eye
namespace: biological_process
def:
  "The progression of an avascular cornea over time, from its formation to the mature structure. Corneal avascularity (the absence of blood vessels in the cornea) is required for optical clarity and optimal vision. Avascular corneas are present in most animals, except Manatees." [GOC:uh, PMID:16849433, PMID:17051153]


id: GO:0036332
name: placental growth factor-activated receptor activity
namespace: molecular_function
def:
  "Combining with placental growth factor (PlGF) and transmitting the signal across the plasma membrane to initiate a change in cell activity." [GOC:uh, PMID:12871269, PMID:7929268, PR:000012605, Wikipedia:Placental_growth_factor]


id: GO:0036333
name: hepatocyte homeostasis
namespace: biological_process
def:
  "Any biological process involved in the maintenance of the steady-state number of hepatocytes within a population of cells. Hepatocytes are specialized epithelial cells of the liver that are organized into interconnected plates called lobules." [CL:0000182, GOC:nhn, PMID:19878874]


id: GO:0036334
name: epidermal stem cell homeostasis
namespace: biological_process
def:
  "Any biological process involved in the maintenance of the steady-state number of epidermal stem cells within a population of cells." [CL:1000428, GOC:nhn, PMID:17666529]


id: GO:0036335
name: intestinal stem cell homeostasis
namespace: biological_process
def:
  "Any biological process involved in the maintenance of the steady-state number of intestinal stem cells within a population of cells." [GOC:nhn, PMID:22042863]


id: GO:0036336
name: dendritic cell migration
namespace: biological_process
def:
  "The movement of a dendritic cell within or between different tissues and organs of the body." [CL:0000451, GOC:nhn, PMID:19339990]


id: GO:0036337
name: Fas signaling pathway
namespace: biological_process
def:
  "A series of molecular signals initiated by the binding of a ligand to the receptor Fas on the surface of the cell, and ending with regulation of a downstream cellular process, e.g. transcription. Fas is a death domain-containing member of the tumor necrosis factor receptor (TNFR) superfamily." [GOC:nhn, PMID:12040174, Wikipedia:Fas_receptor]


id: GO:0036339
name: lymphocyte adhesion to endothelial cell of high endothelial venule
namespace: biological_process
def:
  "The attachment of a lymphocyte to an endothelial cell of a high endothelial venule (HEV) via adhesion molecules. A HEV cell is an endothelial cell that is cuboidal, expresses leukocyte-specific receptors, and allows for passage of lymphocytes into bloodstream." [CL:0000542, CL:0002652, GOC:nhn, PMID:19339990, PMID:7679710, Wikipedia:High_endothelial_venules]


id: GO:0036340
name: chitin-based cuticle sclerotization by biomineralization
namespace: biological_process
def:
  "The process of hardening a chitin-based cuticle by mineral incorporation. For example, the cuticle of crustaceans is hardened by the incorporation of calcium carbonate." [GOC:sart]


id: GO:0036341
name: chitin-based cuticle sclerotization by protein cross-linking
namespace: biological_process
def:
  "The process of hardening of a chitin-based cuticle by protein cross-linking, and the incorporation of phenolic precursors. This mechanism of cuticle hardening occurs in insects and is usually accompanied by darkening of the cuticle." [GOC:bf, GOC:sart]


id: GO:0036342
name: post-anal tail morphogenesis
namespace: biological_process
def:
  "The process in which a post-anal tail is generated and organized. A post-anal tail is a muscular region of the body that extends posterior to the anus. The post-anal tail may aid locomotion and balance." [GOC:bf, GOC:kmv, Wikipedia:Chordate]


id: GO:0036343
name: psychomotor behavior
namespace: biological_process
def:
  "The specific behavior of an organism that combines cognitive functions and physical movement. For example, driving a car, throwing a ball, or playing a musical instrument." [GOC:nhn, GOC:pr, PMID:17159989, Wikipedia:Psychomotor_learning]


id: GO:0036344
name: platelet morphogenesis
namespace: biological_process
def:
  "Generation and organization of a platelet, a non-nucleated disk-shaped cell formed by extrusion from megakaryocytes, found in the blood of all mammals, and mainly involved in blood coagulation." [CL:0000233, GOC:BHF, GOC:vk]


id: GO:0036345
name: platelet maturation
namespace: biological_process
def:
  "A developmental process, independent of morphogenetic (shape) change, that is required for a platelet to attain its fully functional state. A platelet is a non-nucleated disk-shaped cell formed by extrusion from megakaryocytes, found in the blood of all mammals, and mainly involved in blood coagulation." [CL:0000233, GOC:BHF, GOC:vk]


id: GO:0036346
name: cellular response to L-cysteine
namespace: biological_process
def:
  "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a L-cysteine stimulus. L-cysteine is an optically active form of cysteine having L-configuration." [CHEBI:17561, GOC:al]


id: GO:0036347
name: glutathione import into cell
namespace: biological_process
def:
  "The directed movement of glutathione from outside of a cell into the cytoplasmic compartment. This may occur via transport across the plasma membrane or via endocytosis." [GOC:al]


id: GO:0036348
name: hydantoin racemase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: D-5-monosubstituted hydantoin = L-5-monosubstituted hydantoin." [EC:5.1.99.5, InterPro:IPR015942]


id: GO:0036349
name: galactose-specific flocculation
namespace: biological_process
def:
  "The non-sexual aggregation of single-celled organisms mediated by the binding of cell wall proteins on one cell to galactose residues on the other." [GOC:vw, PMID:22098069]


id: GO:0036350
name: mannose-specific flocculation
namespace: biological_process
def:
  "The non-sexual aggregation of single-celled organisms mediated by the binding of cell wall proteins on one cell to mannose residues on the other." [GOC:vw, PMID:9851992]


id: GO:0036351
name: histone H2A-K13 ubiquitination
namespace: biological_process
def:
  "The modification of histone H2A by addition of ubiquitin group at lysine 13 (H2A-K13) in metazoans, and at the equivalent residue in other organisms. Monoubiquitin is first attached to H2A-K13 and K63-linked ubiquitin chains are then extended from this monoubiquitin." [GOC:sp, PMID:22713238, PMID:22980979]


id: GO:0036352
name: histone H2A-K15 ubiquitination
namespace: biological_process
def:
  "The modification of histone H2A by addition of ubiquitin group at lysine 15 (H2A-K15) in metazoans, and at the equivalent residue in other organisms. Monoubiquitin is first attached to H2A-K15 and K63-linked ubiquitin chains are then extended from this monoubiquitin." [GOC:sp, PMID:22713238, PMID:22980979]


id: GO:0036353
name: histone H2A-K119 monoubiquitination
namespace: biological_process
def:
  "The modification of histone H2A by addition of a single ubiquitin group to lysine-119 (H2A- K119) in metazoans, and at the equivalent residue in other organisms." [GOC:sp, PMID:15386022]


id: GO:0036354
name: 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide a dehydrogenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide a = bacteriochlorophyllide a + 2 H+." [GOC:crds, InterPro:IPR005903, MetaCyc:RXN-8787, PMID:8437569]


id: GO:0036355
name: 2-iminoacetate synthase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: L-tyrosine + S-adenosyl-L-methionine + reduced acceptor = 2-iminoacetate + 4-methylphenol + 5'-deoxyadenosine + L-methionine + acceptor + 2 H+." [EC:4.1.99.19, GOC:crds, MetaCyc:RXN-11319, PMID:17403671]


id: GO:0036356
name: cyclic 2,3-diphosphoglycerate synthetase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 2,3-diphosphoglycerate (DPG) + ATP = cyclic 2,3-diphosphoglycerate (cDPG) + ADP + phosphate." [GOC:crds, PMID:2226838, PMID:8320225, PMID:9811660]


id: GO:0036357
name: 2-phosphoglycerate kinase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 2-phosphoglycerate + ATP = 2,3-diphosphoglycerate + ADP." [GOC:bf, InterPro:IPR020872, PMID:2226838, PMID:8159166]


id: GO:0036358
name: lipoteichoic acid D-alanylation
namespace: biological_process
def:
  "The formation of a D-alanyl ester of lipoteichoic acid by transfer of D-Ala onto a membrane-associated lipoteichoic acid (LTA)." [GOC:crds, PMID:22750871, PMID:8682792]


id: GO:0036360
name: sorocarp stalk morphogenesis
namespace: biological_process
def:
  "The process in which the sorocarp stalk is generated and organized. The sorocarp stalk is a tubular structure that consists of cellulose-covered cells stacked on top of each other and surrounded by an acellular stalk tube composed of cellulose and glycoprotein. An example of this process is found in Dictyostelium discoideum." [DDANAT:0000068, GOC:pf, PMID:22902739]


id: GO:0036361
name: racemase activity, acting on amino acids and derivatives
namespace: molecular_function
def:
  "Catalysis of the interconversion of the two enantiomers of a chiral amino acid or amino acid derivative." [GOC:crds]


id: GO:0036362
name: ascus membrane
namespace: cellular_component
def:
  "A double layer of lipid molecules that surrounds an ascus, a capsule containing the sexual spores in some fungi." [GOC:mcc, GOC:vw, PMID:21900489]


id: GO:0036363
name: transforming growth factor beta activation
namespace: biological_process
def:
  "The release of transforming growth factor beta (TGF-beta) from its latent state. TGF-beta is secreted as part of a large latent complex (LLC) that is targeted to the extracellular matrix. Release of TGFbeta from its latent state is required for TGFbeta to bind to its receptors, and can occur by a variety of mechanisms." [GOC:bf, GOC:sl, PMID:12482908, PMID:9170210]


id: GO:0036364
name: transforming growth factor beta1 activation
namespace: biological_process
def:
  "The release of transforming growth factor beta1 (TGF-beta1) from its latent state." [GOC:sl, PMID:12482908, PMID:9170210]


id: GO:0036365
name: transforming growth factor beta2 activation
namespace: biological_process
def:
  "The release of transforming growth factor beta 2 (TGF-beta2) from its latent state." [GOC:sl, PMID:12482908, PMID:9170210]


id: GO:0036366
name: transforming growth factor beta3 activation
namespace: biological_process
def:
  "The release of transforming growth factor beta 3 (TGF-beta3) from its latent state." [GOC:sl, PMID:12482908, PMID:9170210]


id: GO:0036368
name: cone photoresponse recovery
namespace: biological_process
def:
  "The processes required for a cone photoreceptor to recover, following light activation, so that it can respond to a subsequent light stimulus. Cone recovery requires the shutoff of active participants in the phototransduction cascade, including the visual pigment and downstream signal transducers." [GOC:gap, PMID:16039565, PMID:22802362]


id: GO:0036369
name: transcription factor catabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the breakdown of a sequence-specific DNA binding transcription factor by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:al, GOC:vw, PMID:22833559]


id: GO:0036370
name: D-alanyl carrier activity
namespace: molecular_function
def:
  "Accepts activated D-alanine and subsequently transfers D-alanine onto a teichoic acid acceptor molecule. The carrier protein provides an essential link between the D-alanine-D-alanyl carrier protein ligase and the incorporation of D-alanine into the substrate." [GOC:crds, PMID:11222605, PMID:22750871, PMID:8682792]


id: GO:0036371
name: protein localization to T-tubule
namespace: biological_process
def:
  "A process in which a protein is transported to, or maintained in, the T-tubule. The T-tubule is an invagination of the plasma membrane of a muscle cell that extends inward from the cell surface around each myofibril." [GOC:BHF, GOC:rl, PMID:16292983]


id: GO:0036372
name: opsin transport
namespace: biological_process
def:
  "The directed movement of an opsin (a G-protein coupled receptor of photoreceptor cells) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore." [GOC:atm, PMID:20238016, PMID:22855808]


id: GO:0036374
name: glutathione hydrolase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: glutathione + H2O = L-cysteinylglycine + L-glutamate." [EC:3.4.19.13, GOC:imk]


id: GO:0036375
name: Kibra-Ex-Mer complex
namespace: cellular_component
def:
  "An apical protein complex that contains the proteins Kibra, Expanded and Merlin (Mer), or orthologs thereof. In humans, the complex contains KIBRA, FDM6 and NF2." [PMID:20159598]


id: GO:0036377
name: arbuscular mycorrhizal association
namespace: biological_process
def:
  "A form of mutualism between a fungus and the roots of a vascular plant, where hyphae of the fungus penetrate the plant cell wall and invaginate its cell membrane. Once inside, the fungus forms highly branched structures for nutrient exchange with the plant called arbuscules. Aids in the acquisition by the plant of nutrients such as phosphorus from the soil." [GOC:sk, Wikipedia:Arbuscular_mycorrhiza]


id: GO:0036378
name: calcitriol biosynthetic process from calciol
namespace: biological_process
def:
  "Conversion of vitamin D3 from its largely inactive form (calciol, also called cholecalciferol) into a hormonally active form (calcitriol). Conversion requires 25-hydroxylation of calciol in the liver to form calcidiol, and subsequent 1,alpha-hydroxylation of calcidiol in the kidney to form calcitriol." [GOC:BHF, GOC:rl, PMID:17426122, PMID:20511049]


id: GO:0036379
name: myofilament
namespace: cellular_component
def:
  "Any of the smallest contractile units of a myofibril (striated muscle fiber)." [Wikipedia:Myofilament]


id: GO:0036380
name: UDP-N-acetylglucosamine-undecaprenyl-phosphate N-acetylglucosaminephosphotransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: UDP-N-acetyl-alpha-D-glucosamine + ditrans,octacis-undecaprenyl phosphate = UMP + N-acetyl-alpha-D-glucosaminyldiphospho-ditrans,octacis-undecaprenol." [EC:2.7.8.33, GOC:rs]


id: GO:0036381
name: pyridoxal 5'-phosphate synthase (glutamine hydrolysing) activity
namespace: molecular_function
def:
  "Catalysis of the reaction: D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + L-glutamine = pyridoxal 5'-phosphate + L-glutamate + 3 H2O + phosphate. The reaction occurs in two steps: L-glutamine + H2O = L-glutamate + NH3, and subsequently D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + NH3 = pyridoxal 5'-phosphate + 4 H2O + phosphate." [EC:4.3.3.6, GOC:rs]


id: GO:0036383
name: 3-hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione monooxygenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 3-hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + FMNH2 + O2 = 3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + FMN + H2O." [EC:1.14.14.12, GOC:rs]


id: GO:0036385
name: nucleoid DNA packaging
namespace: biological_process
def:
  "Any process in which DNA and associated proteins are formed into a compact, orderly structure within a nucleoid." [GOC:bf, GOC:bhm]


id: GO:0036386
name: bacterial nucleoid DNA packaging
namespace: biological_process
def:
  "Compaction of DNA in a bacterial nucleoid into a compact structure. Often achieved by DNA supercoiling." [GOC:bf, GOC:bhm, PMID:17097674, PMID:17360520]


id: GO:0036387
name: pre-replicative complex
namespace: cellular_component
def:
  "A protein-DNA complex that forms at the origin of replication during the initial step of DNA replication and allows the origin to become competent, or 'licensed', for replication." [GOC:bf, GOC:bhm, GOC:jh2, Wikipedia:Pre-replication_complex]


id: GO:0036388
name: pre-replicative complex assembly
namespace: biological_process
def:
  "The aggregation, arrangement and bonding together of a set of components to form the pre-replicative complex, a protein-DNA complex that forms at the origin of replication during the initial step of DNA replication and allows the origin to become competent, or 'licensed', for replication." [GOC:bf, GOC:bhm, GOC:jh2]


id: GO:0036389
name: bacterial pre-replicative complex
namespace: cellular_component
def:
  "A protein-DNA complex that forms at the bacterial oriC during the initial step of DNA replication and allows the origin to become competent, or 'licensed', for replication." [GOC:bf, GOC:bhm, GOC:jh2, PMID:19833870, PMID:21035377, Wikipedia:Pre-replication_complex]


id: GO:0036390
name: pre-replicative complex assembly involved in bacterial-type DNA replication
namespace: biological_process
def:
  "The aggregation, arrangement and bonding together of a set of components to form the bacterial pre-replicative complex, a protein-DNA complex that forms at the bacterial oriC during the initial step of DNA replication and allows the origin to become competent, or 'licensed', for replication." [GOC:bf, GOC:bhm, GOC:jh2, PMID:19833870, PMID:21035377, PMID:21895796]


id: GO:0036391
name: medial cortex septin ring
namespace: cellular_component
def:
  "A ring-shaped structure that forms at the medial cortex of a symmetrically dividing cell at the onset of cytokinesis; composed of members of the conserved family of filament forming proteins called septins as well as septin-associated proteins." [GOC:vw, PMID:16009555]


id: GO:0036392
name: chemokine (C-C motif) ligand 20 production
namespace: biological_process
def:
  "The appearance of chemokine (C-C motif) ligand 20 (CCL20) due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:jc]


id: GO:0036393
name: thiocyanate peroxidase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: thiocyanate (SCN-) + hydrogen peroxide (H2O2) = hypothiocyanite (OSCN-) + 2 H2O. Catalyzes the hydrogen peroxide oxidation of thiocyanate." [GOC:pm, PMID:12626341]


id: GO:0036396
name: MIS complex
namespace: cellular_component
def:
  "An mRNA methyltransferase complex that catalyzes the post-transcriptional methylation of adenosine to form N6-methyladenosine (m6A). In budding yeast, the MIS complex consists of Mum2p, Ime4p and Slz1p. In vertebrates, the complex consists of METTL3, METTL14 and WTAP." [GOC:dgf, GOC:sp, PMID:22685417, PMID:24316715]


id: GO:0036398
name: TCR signalosome
namespace: cellular_component
def:
  "A multi-protein complex containing at least the T-cell receptor complex and the LAT (linker for activation of T cells) scaffold protein. Also contains a variety of signaling proteins including co-receptors, kinases, phosphatases and adaptors such as CD8. Connects events on the plasma membrane to distal signaling cascades to ultimately modulate T cell biology." [GOC:krc, PMID:17534068, PMID:20107804, PMID:22426112]


id: GO:0036399
name: TCR signalosome assembly
namespace: biological_process
def:
  "The aggregation, arrangement and bonding together of a set of components to form a TCR signalosome." [GOC:krc, PMID:22426112]


id: GO:0036400
name: short neuropeptide F receptor activity
namespace: molecular_function
def:
  "Combining with a short neuropeptide F and transmitting the signal within the cell to initiate a change in cell activity. Short neuropeptide F is an arthropod peptide of less than 28 residues (as small as 8-10 residues in some species) with a C-terminal RFamide or LRFamide." [GOC:ha, PMID:16330127, PMID:21440021]


id: GO:0036401
name: pyrokinin receptor activity
namespace: molecular_function
def:
  "Combining with a pyrokinin and transmitting the signal within the cell to induce a change in cell activity. Pyrokinins are a group of insect neuropeptides that share the common C-terminal pentapeptide sequence Phe-X-Pro-Arg-Leu-NH2 (X = S, T, K, A, or G). They play a central role in diverse physiological processes including stimulation of gut motility, production and release of sex pheromones, diapause, and pupariation." [GOC:ha, PMID:12951076, PMID:19186060]


id: GO:0036402
name: proteasome-activating ATPase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: ATP + H2O = ADP + phosphate, which promotes unfolding of protein substrates, and channel opening of the core proteasome." [GOC:rb, PMID:11430818]


id: GO:0036403
name: arachidonate 8(S)-lipoxygenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: arachidonate + O(2) = (5Z,8S,9E,11Z,14Z)-8-hydroperoxyicosa-5,9,11,14-tetraenoate." [EC:1.13.11.-, GOC:lb, PMID:10625675]


id: GO:0036404
name: conversion of ds siRNA to ss siRNA
namespace: biological_process
def:
  "The process in which double-stranded small interfering RNA (ds siRNA) molecules are converted to single-stranded small interfering RNA (ss siRNA)." [GOC:vw]


id: GO:0036405
name: anchored component of cell outer membrane
namespace: cellular_component
def:
  "The component of the cell outer membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping." [GOC:dos, GOC:md]


id: GO:0036406
name: anchored component of periplasmic side of cell outer membrane
namespace: cellular_component
def:
  "The component of the cell outer membrane consisting of gene products and protein complexes that are tethered to the periplasmic side of membrane by only a covalently attached anchor, embedded in the periplasmic side of the membrane only." [GOC:dos, GOC:md]


id: GO:0036407
name: mycolate outer membrane
namespace: cellular_component
def:
  "A mycolic acid-rich cell outer membrane containing a lipid bilayer and long-chain mycolic acids (hydroxylated branched-chain fatty acids) that are covalently linked to the cell wall peptidoglycan via an arabinogalactan network. Found in mycobacteria and related genera (e.g. corynebacteria)." [GOC:bf, GOC:das, GOC:md, PMID:18316738, PMID:18567661]


id: GO:0036408
name: histone acetyltransferase activity (H3-K14 specific)
namespace: molecular_function
def:
  "Catalysis of the reaction: acetyl-CoA + histone H3 L-lysine (position 14) = CoA + histone H3 N6-acetyl-L-lysine (position 14)." [GOC:vw, PMID:21289066]


id: GO:0036409
name: histone H3-K14 acetyltransferase complex
namespace: cellular_component
def:
  "A protein complex that can catalyze the acetylation of lysine at position 14 in histone H3." [GOC:vw, PMID:21289066]


id: GO:0036410
name: Mst2 histone acetyltransferase complex
namespace: cellular_component
def:
  "A protein complex that can catalyze the acetylation of lysine at position 14 in histone H3, and contains Mst2 as the catalytic subunit. In fission yeast, contains at least Mst2, Nto1, Ptf2, Ptf1 and Eaf6." [GOC:vw, PMID:21289066]


id: GO:0036411
name: H-NS-Cnu complex
namespace: cellular_component
def:
  "A trimeric protein complex containing a H-NS homodimer and a Cnu monomer. In bacteria, this complex negatively regulates transcription of a range of genes." [GOC:bhm, PMID:18189420, PMID:22358512]


id: GO:0036413
name: histone H3-R26 citrullination
namespace: biological_process
def:
  "The hydrolysis of peptidyl-arginine to form peptidyl-citrulline at position 26 in histone H3." [GOC:als, PMID:22853951]


id: GO:0036414
name: histone citrullination
namespace: biological_process
def:
  "The hydrolysis of peptidyl-arginine to form peptidyl-citrulline on a histone protein." [GOC:als, PMID:22853951, PMID:23175390]


id: GO:0036415
name: regulation of tRNA stability
namespace: biological_process
def:
  "Any process that modulates the propensity of transfer RNA (tRNA) molecules to degradation. Includes processes that both stabilize and destabilize tRNAs." [GOC:aa, PMID:21502523, PMID:23572593]


id: GO:0036417
name: tRNA destabilization
namespace: biological_process
def:
  "Any process that decreases the stability of a tRNA molecule, making it more vulnerable to degradative processes." [GOC:aa, GOC:bf]


id: GO:0036418
name: intrinsic component of mycolate outer membrane
namespace: cellular_component
def:
  "The component of the mycolate outer membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane." [GOC:dos, GOC:md]


id: GO:0036419
name: integral component of mycolate outer membrane
namespace: cellular_component
def:
  "The component of the mycolate outer membrane consisting of the gene products having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:md]


id: GO:0036420
name: extrinsic component of mycolate outer membrane
namespace: cellular_component
def:
  "The component of mycolate outer membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:dos, GOC:md]


id: GO:0036421
name: extrinsic component of external side of mycolate outer membrane
namespace: cellular_component
def:
  "The component of mycolate membrane consisting of gene products and protein complexes that are loosely bound to its external surface, but not integrated into the hydrophobic region." [GOC:md]


id: GO:0036422
name: heptaprenyl diphosphate synthase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: (2E,6E)-farnesyl diphosphate + 4 isopentenyl diphosphate = 4 diphosphate + all-trans-heptaprenyl diphosphate." [EC:2.5.1.30, RHEA:27797]


id: GO:0036423
name: hexaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) activity
namespace: molecular_function
def:
  "Catalysis of the reaction: (2E,6E)-farnesyl diphosphate + 3 isopentenyl diphosphate = 3 diphosphate + all-trans-hexaprenyl diphosphate." [EC:2.5.1.83, RHEA:27562]


id: GO:0036426
name: ditrans, polycis-undecaprenyl-phosphate mannosyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: ditrans,octacis-undecaprenyl phosphate + GDP-alpha-D-mannose = D-mannosyl undecaprenyl phosphate+ GDP." [RHEA:28121]


id: GO:0036427
name: all-trans-undecaprenyl-phosphate mannosyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: all-trans-undecaprenyl phosphate + GDP-alpha-D-mannose = D-mannosyl undecaprenyl phosphate + GDP." [RHEA:12784]


id: GO:0036428
name: adenosylcobinamide kinase (GTP-specific) activity
namespace: molecular_function
def:
  "Catalysis of the reaction: adenosylcobinamide + GTP = adenosylcobinamide phosphate + GDP + H+." [RHEA:15768]


id: GO:0036429
name: adenosylcobinamide kinase (ATP-specific) activity
namespace: molecular_function
def:
  "Catalysis of the reaction: adenosylcobinamide + ATP = adenosylcobinamide phosphate + ADP + H+." [RHEA:15772]


id: GO:0036432
name: all-trans undecaprenol kinase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: ATP + undecaprenol + all-trans-undecaprenyl phosphate + ADP + H+." [RHEA:23755]


id: GO:0036433
name: di-trans, poly-cis-undecaprenol kinase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: di-trans, octa-cis-undecaprenol + ATP = di-trans,octa-cis-undecaprenyl phosphate + ADP + H+." [RHEA:28125]


id: GO:0036434
name: nitronate monooxygenase (FMN-linked) activity
namespace: molecular_function
def:
  "Catalysis of the reaction: ethylnitronate + FMNH(2) + O(2) = acetaldehyde + FMN + H(2)O + H(+) + nitrite." [RHEA:26461]


id: GO:0036435
name: K48-linked polyubiquitin binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently and non-covalently with a polymer of ubiquitin formed by linkages between lysine residues at position 48 of the ubiquitin monomers." [GOC:al, PMID:20739285]


id: GO:0036436
name: Isw1a complex
namespace: cellular_component
def:
  "An Isw1 complex that binds DNA and has nucleosome-stimulated ATPase activity. In S. cerevisiae, contains an Isw1p ATPase subunit in complex with Ioc3p." [GOC:jd, PMID:12482963]


id: GO:0036437
name: Isw1b complex
namespace: cellular_component
def:
  "An Isw1 complex that binds DNA and has nucleosome-stimulated ATPase activity. In S. cerevisiae, contains an Isw1p ATPase subunit in complex with Ioc2p and Ioc4p." [GOC:jd, PMID:12482963]


id: GO:0036438
name: maintenance of lens transparency
namespace: biological_process
def:
  "A homeostatic process in which the lens is maintained in a highly refractive, transparent state to allow for optimal focusing of light on the retina." [GOC:nhn, PMID:22095752]


id: GO:0036439
name: glycerol-3-phosphate dehydrogenase [NADP+] activity
namespace: molecular_function
def:
  "Catalysis of the reaction: glycerol 3-phosphate + NADP+ = glycerone phosphate + H+ + NADPH." [RHEA:11099]


id: GO:0036441
name: 2-dehydropantolactone reductase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: (R)-pantolactone + NADP+ = 2-dehydropantolactone + NADPH + H+." [RHEA:18984]


id: GO:0036442
name: hydrogen-exporting ATPase activity
namespace: molecular_function
def:
  "Catalysis of the transfer of protons from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) -> ADP + phosphate + H+(out)." [RHEA:20855]


id: GO:0036443
name: dermatan 6-sulfotransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 3'-phosphoadenylyl sulfate + dermatan = adenosine 3',5'-bisphosphate + dermatan 6'-sulfate." [EC:2.8.2.33, GOC:bf, KEGG:R07288]


id: GO:0036444
name: calcium ion transmembrane import into mitochondrion
namespace: biological_process
def:
  "A process in which a calcium ion (Ca2+) is transported from one side of a membrane to the other into the mitochondrion by means of some agent such as a transporter or pore." [GOC:vw]


id: GO:0036446
name: myofibroblast differentiation
namespace: biological_process
def:
  "The process in which an undifferentiated cell acquires the features of a myofibroblast cell." [CL:0000186, GOC:nhn]


id: GO:0036447
name: cellular response to sugar-phosphate stress
namespace: biological_process
def:
  "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of the accumulation of sugar-phosphate." [GOC:am, PMID:17383224]


id: GO:0036448
name: cellular response to glucose-phosphate stress
namespace: biological_process
def:
  "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of the accumulation of glucose-phosphate." [GOC:am, PMID:17383224]


id: GO:0036450
name: polyuridylation-dependent decapping of nuclear-transcribed mRNA
namespace: biological_process
def:
  "Cleavage of the 5'-cap of a nuclear-transcribed mRNA that has been modified by the enzymatic addition of a sequence of uridylyl residues (polyuridylation) at the 3' end." [GOC:vw, PMID:19430462]


id: GO:0036451
name: cap mRNA methylation
namespace: biological_process
def:
  "Methylation of the 2'-O-ribose of the first or second transcribed nucleotide of a 5'-capped mRNA." [GOC:bf, PMID:20713356]


id: GO:0036453
name: transitive RNA interference
namespace: biological_process
def:
  "An RNA interference where the silencing signal spreads along the target mRNA in a 5' or 3' direction, outside of the initial target sequence." [GOC:pf, PMID:11719187, PMID:12554873, PMID:23724097, PMID:24369430]


id: GO:0036455
name: iron-sulfur transferase activity
namespace: molecular_function
def:
  "Catalysis of the transfer of a iron-sulfur cluster from one compound (donor) to another (acceptor)." [GOC:bhm]


id: GO:0036456
name: L-methionine-(S)-S-oxide reductase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: L-methionine (S)-S-oxide + thioredoxin -> L-methionine + thioredoxin disulfide + H2O." [GOC:vw, RHEA:19995]


id: GO:0036457
name: keratohyalin granule
namespace: cellular_component
def:
  "A cytoplasmic, non-membrane bound granule of, at least, keratinocyte. Associated to keratin intermediate filaments and partially crosslinked to the cell envelope." [GOC:krc, PMID:15854042]


id: GO:0036459
name: thiol-dependent ubiquitinyl hydrolase activity
namespace: molecular_function
def:
  "Catalysis of the thiol-dependent hydrolysis of an ester, thioester, amide, peptide or isopeptide bond formed by the C-terminal glycine of ubiquitin." [EC:3.4.19.12, GOC:bf, GOC:ka]


id: GO:0036460
name: cellular response to cell envelope stress
namespace: biological_process
def:
  "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stress acting at the cell envelope." [GOC:imk, PMID:15101969, PMID:15882407]


id: GO:0036461
name: BLOC-2 complex binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with a BLOC-2 complex, a protein complex required for the biogenesis of specialized organelles of the endosomal-lysosomal system, such as melanosomes and platelet dense granules." [GOC:bf, GOC:PARL, PMID:22511774]


id: GO:0036462
name: TRAIL-activated apoptotic signaling pathway
namespace: biological_process
def:
  "An extrinsic apoptotic signaling pathway initiated by the binding of the ligand TRAIL (tumor necrosis factor-related apoptosis-inducing ligand) to a death receptor on the cell surface." [GOC:bf, GOC:PARL, PMID:21785459]


id: GO:0036463
name: TRAIL receptor activity
namespace: molecular_function
def:
  "Combining with the ligand TRAIL (tumor necrosis factor-related apoptosis-inducing ligand) and transmitting the signal from one side of the plasma membrane to the other to initiate apoptotic cell death." [GOC:bf, GOC:PARL]


id: GO:0036465
name: synaptic vesicle recycling
namespace: biological_process
def:
  "The trafficking of synaptic vesicles from the pre-synaptic membrane so the vesicle can dock and prime for another round of exocytosis and neurotransmitter release. Recycling occurs after synaptic vesicle exocytosis, and is necessary to replenish presynaptic vesicle pools, sustain transmitter release and preserve the structural integrity of the presynaptic membrane." [GOC:bf, GOC:pad, GOC:PARL, PMID:15217342, PMID:22026965, PMID:23245563]


id: GO:0036466
name: synaptic vesicle recycling via endosome
namespace: biological_process
def:
  "Synaptic vesicle recycling where vesicles endocytose via clathrin-coated pits, re-acidify, and refill with neurotransmitters after passing through an endosomal intermediate." [GOC:bf, GOC:dos, GOC:pad, GOC:PARL, PMID:15217342]


id: GO:0036467
name: 5-hydroxy-L-tryptophan decarboxylase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 5-hydroxy-L-tryptophan + H+ = CO2 + serotonin." [GOC:bf, GOC:PARL, RHEA:18536]


id: GO:0036470
name: tyrosine 3-monooxygenase activator activity
namespace: molecular_function
def:
  "Interacts with and increases tyrosine 3-monooxygenase (tyrosine hydroxylase) activity." [GOC:bf, GOC:PARL, PMID:19703902]


id: GO:0036471
name: cellular response to glyoxal
namespace: biological_process
def:
  "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glyoxal stimulus." [GOC:bf, GOC:PARL]


id: GO:0036472
name: suppression by virus of host protein binding
namespace: biological_process
def:
  "Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of interaction between host proteins." [GOC:bf, GOC:PARL, PMID:17297443]


id: GO:0036473
name: cell death in response to oxidative stress
namespace: biological_process
def:
  "Any biological process that results in permanent cessation of all vital functions of a cell upon exposure to an oxidative stress stimulus." [GOC:bf, GOC:PARL]


id: GO:0036474
name: cell death in response to hydrogen peroxide
namespace: biological_process
def:
  "Any biological process that results in permanent cessation of all vital functions of a cell upon exposure to hydrogen peroxide (H2O2)." [GOC:bf, GOC:PARL]


id: GO:0036475
name: neuron death in response to oxidative stress
namespace: biological_process
def:
  "Any biological process that results in permanent cessation of all vital functions of a neuron upon exposure to an oxidative stress stimulus." [GOC:bf, GOC:PARL]


id: GO:0036476
name: neuron death in response to hydrogen peroxide
namespace: biological_process
def:
  "Any biological process that results in permanent cessation of all vital functions of a neuron upon exposure to hydrogen peroxide (H2O2)." [GOC:bf, GOC:PARL]


id: GO:0036477
name: somatodendritic compartment
namespace: cellular_component
def:
  "The region of a neuron that includes the cell body (cell soma) and the dendrite, but excludes the axon." [GOC:pad, GOC:PARL]


id: GO:0036480
name: neuron intrinsic apoptotic signaling pathway in response to oxidative stress
namespace: biological_process
def:
  "A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a neuron. The pathway is induced in response to oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, and ends when the execution phase of apoptosis is triggered." [GOC:bf, GOC:PARL, PMID:23858059]


id: GO:0036481
name: intrinsic apoptotic signaling pathway in response to hydrogen peroxide
namespace: biological_process
def:
  "A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced in response to hydrogen peroxide (H2O2)." [GOC:bf, GOC:PARL]


id: GO:0036482
name: neuron intrinsic apoptotic signaling pathway in response to hydrogen peroxide
namespace: biological_process
def:
  "A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a neuron in response to hydrogen peroxide." [GOC:bf, GOC:PARL]


id: GO:0036483
name: neuron intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
namespace: biological_process
def:
  "A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a neuron. The pathway is induced in response to a stimulus indicating endoplasmic reticulum (ER) stress, and ends when the execution phase of apoptosis is triggered. ER stress usually results from the accumulation of unfolded or misfolded proteins in the ER lumen." [GOC:bf, GOC:PARL, PMID:21113145]


id: GO:0036484
name: trunk neural crest cell migration
namespace: biological_process
def:
  "The characteristic movement of trunk neural crest cells from the neural tube to other locations in the vertebrate embryo." [CL:0000011, GOC:bf, GOC:mat, GOC:PARL, PMID:2387238]


id: GO:0036485
name: dorsolateral trunk neural crest cell migration
namespace: biological_process
def:
  "The movement of trunk neural crest cells from the neural tube, travelling dorso-laterally into the ectoderm and continuing toward the ventral midline of the belly. These migrating trunk neural crest cells become melanocytes, the melanin-forming pigment cells." [GOC:bf, GOC:mat, GOC:PARL, PMID:2387238]


id: GO:0036486
name: ventral trunk neural crest cell migration
namespace: biological_process
def:
  "The movement of trunk neural crest cells from the neural tube, travelling ventrally through the anterior half of each sclerotome. Trunk neural crest cells that remain in the sclerotome form the dorsal root ganglia containing the sensory neurons. Trunk neural crest cells that continue more ventrally form the sympathetic ganglia, the adrenal medulla, and the nerve clusters surrounding the aorta." [GOC:bf, GOC:mat, GOC:PARL, PMID:16319111, PMID:19386662]


id: GO:0036487
name: nitric-oxide synthase inhibitor activity
namespace: molecular_function
def:
  "Interacts with, and stops, prevents or reduces the activity of nitric oxide synthase." [GOC:BHF, GOC:rl, PMID:17242280]


id: GO:0036488
name: CHOP-C/EBP complex
namespace: cellular_component
def:
  "A heterodimeric protein complex that is composed of the transcription factor CHOP (GADD153) and a member of the C/EBP family of transcription factors." [GOC:bf, GOC:PARL, PMID:1547942]


id: GO:0036489
name: neuromelanin biosynthetic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of neuromelanin. Neuromelanin is a polymer of 5,6-dihydroxyindole monomers." [GOC:bf, GOC:PARL, Wiki:Neuromelanin]


id: GO:0036490
name: regulation of translation in response to endoplasmic reticulum stress
namespace: biological_process
def:
  "Modulation of the frequency, rate or extent of translation as a result of endoplasmic reticulum stress." [GOC:bf, GOC:PARL, PMID:14676213, PMID:16835242]


id: GO:0036491
name: regulation of translation initiation in response to endoplasmic reticulum stress
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of translation initiation, as a result of endoplasmic reticulum stress." [GOC:bf, GOC:PARL, PMID:14676213, PMID:16835242]


id: GO:0036492
name: eiF2alpha phosphorylation in response to endoplasmic reticulum stress
namespace: biological_process
def:
  "The addition of a phosphate group on to the translation initiation factor eIF2alpha, as a result of endoplasmic reticulum stress." [GOC:bf, GOC:PARL, PMID:14676213, PMID:16835242]


id: GO:0036493
name: positive regulation of translation in response to endoplasmic reticulum stress
namespace: biological_process
def:
  "Any process that activates, or increases the frequency, rate or extent of translation as a result of endoplasmic reticulum stress." [GOC:bf, GOC:PARL]


id: GO:0036494
name: positive regulation of translation initiation in response to endoplasmic reticulum stress
namespace: biological_process
def:
  "Any process that activates, or increases the frequency, rate or extent of translation initiation as a result of endoplasmic reticulum stress." [GOC:bf, GOC:PARL]


id: GO:0036495
name: negative regulation of translation initiation in response to endoplasmic reticulum stress
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of translation initiation as a result of endoplasmic reticulum stress." [GOC:bf, GOC:PARL]


id: GO:0036496
name: regulation of translational initiation by eIF2 alpha dephosphorylation
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of translation initiation in response to stress by the dephosphorylation of eIF2 alpha." [GOC:bf, GOC:PARL]


id: GO:0036497
name: eIF2alpha dephosphorylation in response to endoplasmic reticulum stress
namespace: biological_process
def:
  "The removal of a phosphate group from the translation initiation factor eIF2alpha, as a result of endoplasmic reticulum stress." [GOC:bf, GOC:PARL, PMID:16835242]


id: GO:0036498
name: IRE1-mediated unfolded protein response
namespace: biological_process
def:
  "A series of molecular signals mediated by the endoplasmic reticulum stress sensor IRE1 (Inositol-requiring transmembrane kinase/endonuclease). Begins with activation of IRE1 in response to endoplasmic reticulum (ER) stress, and ends with regulation of a downstream cellular process, e.g. transcription. One target of activated IRE1 is the transcription factor HAC1 in yeast, or XBP1 in mammals; IRE1 cleaves an intron of a mRNA coding for HAC1/XBP1 to generate an activated HAC1/XBP1 transcription factor, which controls the up regulation of UPR-related genes. At least in mammals, IRE1 can also signal through additional intracellular pathways including JNK and NF-kappaB." [GOC:bf, GOC:PARL, PMID:22013210]


id: GO:0036499
name: PERK-mediated unfolded protein response
namespace: biological_process
def:
  "A series of molecular signals mediated by the endoplasmic reticulum membrane stress sensor PERK (PKR-like ER kinase). Begins with activation of PERK in response to endoplasmic reticulum (ER) stress and ends with regulation of a downstream cellular process, e.g. transcription. The main substrate of PERK is the translation initiation factor eIF2alpha. Serine-phosphorylation of eIF2alpha by PERK inactivates eIF2alpha and inhibits general protein translation. In addition, eIF2alpha phosphorylation preferentially increases the translation of selective mRNAs such as ATF4 (activating transcription factor 4), which up regulates a subset of UPR genes required to restore folding capacity." [GOC:bf, GOC:PARL, PMID:22013210]


id: GO:0036500
name: ATF6-mediated unfolded protein response
namespace: biological_process
def:
  "A series of molecular signals mediated by the endoplasmic reticulum membrane stress sensor ATF6 (activating transcription factor 6). Begins with activation of ATF6 in response to endoplasmic reticulum (ER) stress, and ends with regulation of a downstream cellular process, e.g. transcription. Under conditions of endoplasmic reticulum stress, ATF6 translocates to the Golgi where it is processed by proteases to release a cytoplasmic domain (ATF6f), which operates as a transcriptional activator of many genes required to restore folding capacity." [GOC:bf, GOC:PARL, PMID:22013210]


id: GO:0036501
name: UFD1-NPL4 complex
namespace: cellular_component
def:
  "A dimeric protein complex that contains the co-factors for the ATPase VCP/p97 (Cdc48p in budding yeast). In mammals, this complex consists of UFD1L (UFD1) and NPLOC4 (NPL4). In budding yeast, the complex is a dimer of Ufd1p and Npl4p." [GOC:bf, GOC:PARL, PMID:10811609, PMID:17289586]


id: GO:0036502
name: Derlin-1-VIMP complex
namespace: cellular_component
def:
  "A protein complex containing, in mammals, Derlin-1 and VCP-interacting membrane protein (VIMP). The complex links the p97/VCP-containing ATPase complex with Derlin-1 during translocation of protein substrates from the endoplasmic reticulum to the cytosol for degradation by the cytosolic proteasome." [GOC:bf, GOC:PARL, PMID:15215856, PMID:16186510]


id: GO:0036503
name: ERAD pathway
namespace: biological_process
def:
  "The series of steps necessary to target endoplasmic reticulum (ER)-resident proteins for degradation by the cytoplasmic proteasome. Begins with recognition of the ER-resident protein, includes retrotranslocation (dislocation) of the protein from the ER to the cytosol, protein modifications necessary for correct substrate transfer (e.g. ubiquitination), transport of the protein to the proteasome, and ends with degradation of the protein by the cytoplasmic proteasome." [GOC:bf, GOC:PARL]


id: GO:0036504
name: Golgi membrane fusion
namespace: biological_process
def:
  "The joining of two lipid bilayers that surround the Golgi apparatus to form a single Golgi membrane." [GOC:bf, GOC:PARL, PMID:12473691]


id: GO:0036505
name: prosaposin receptor activity
namespace: molecular_function
def:
  "Combining with prosaposin to initiate a change in cell activity. Prosaposin is the glycoprotein precursor of four cleavage products (saposins A, B, C and D)." [GOC:bf, GOC:PARL, PMID:23690594, PMID:9388493, PR:000031300]


id: GO:0036506
name: maintenance of unfolded protein
namespace: biological_process
def:
  "Maintaining a protein in an unfolded, soluble state." [GOC:bf, GOC:BHF, GOC:nc, GOC:PARL, PMID:21636303]


id: GO:0036507
name: protein demannosylation
namespace: biological_process
def:
  "The removal of one or more mannose residues from a mannosylated protein." [GOC:bf, GOC:PARL, PMID:25092655]


id: GO:0036508
name: protein alpha-1,2-demannosylation
namespace: biological_process
def:
  "The removal of one or more alpha 1,2-linked mannose residues from a mannosylated protein." [GOC:bf, GOC:PARL, PMID:21062743, PMID:25092655]


id: GO:0036509
name: trimming of terminal mannose on B branch
namespace: biological_process
def:
  "The removal of an alpha-1,2-linked mannose from the B-chain of a glycoprotein oligosaccharide in the endoplasmic reticulum." [GOC:bf, GOC:PARL, KEGG:R06722, PMID:22160784]


id: GO:0036510
name: trimming of terminal mannose on C branch
namespace: biological_process
def:
  "The removal of an alpha-1,2-linked mannose from the C-chain of a glycoprotein oligosaccharide in the endoplasmic reticulum." [GOC:bf, GOC:PARL, PMID:20065073]


id: GO:0036511
name: trimming of first mannose on A branch
namespace: biological_process
def:
  "The removal of the first alpha-1,2-linked mannose from the A-chain of a glycoprotein oligosaccharide in the endoplasmic reticulum." [GOC:bf, GOC:PARL, PMID:12829701]


id: GO:0036512
name: trimming of second mannose on A branch
namespace: biological_process
def:
  "The removal of the second alpha-1,2-linked mannose from the A-chain of a glycoprotein oligosaccharide in the endoplasmic reticulum." [GOC:bf, GOC:PARL, PMID:12829701]


id: GO:0036513
name: Derlin-1 retrotranslocation complex
namespace: cellular_component
def:
  "A protein complex that functions in the retrotranslocation step of ERAD (ER-associated protein degradation), and includes at its core Derlin-1 oligomers forming a retrotranslocation channel." [GOC:bf, GOC:PARL, PMID:15215856, PMID:16186510]


id: GO:0036514
name: dopaminergic neuron axon guidance
namespace: biological_process
def:
  "The chemotaxis process that directs the migration of an axon growth cone of a dopaminergic neuron to a specific target site in response to a combination of attractive and repulsive cues." [GOC:bf, GOC:PARL, PMID:21106844, PMID:23517308]


id: GO:0036515
name: serotonergic neuron axon guidance
namespace: biological_process
def:
  "The chemotaxis process that directs the migration of an axon growth cone of a serotonergic neuron to a specific target site in response to a combination of attractive and repulsive cues." [CL:0000850, GOC:bf, GOC:PARL, PMID:21106844]


id: GO:0036516
name: chemoattraction of dopaminergic neuron axon
namespace: biological_process
def:
  "The process in which a dopaminergic neuron growth cone is directed to a specific target site in response to an attractive chemical signal." [GOC:bf, GOC:PARL, PMID:21106844]


id: GO:0036517
name: chemoattraction of serotonergic neuron axon
namespace: biological_process
def:
  "The process in which a serotonergic neuron growth cone is directed to a specific target site in response to an attractive chemical signal." [CL:0000850, GOC:bf, GOC:PARL, PMID:21106844]


id: GO:0036518
name: chemorepulsion of dopaminergic neuron axon
namespace: biological_process
def:
  "The process in which a dopaminergic neuron growth cone is directed to a specific target site in response to a repulsive chemical cue." [GOC:bf, GOC:PARL, PMID:21106844, PMID:23517308]


id: GO:0036519
name: chemorepulsion of serotonergic neuron axon
namespace: biological_process
def:
  "The process in which a serotonergic neuron growth cone is directed to a specific target site in response to a repulsive chemical cue." [CL:0000850, GOC:bf, GOC:PARL, PMID:21106844]


id: GO:0036520
name: astrocyte-dopaminergic neuron signaling
namespace: biological_process
def:
  "Cell-cell signaling that mediates the transfer of information from an astrocyte to a dopaminergic neuron." [GOC:bf, GOC:PARL, PMID:12794311, PMID:21752258]


id: GO:0038001
name: paracrine signaling
namespace: biological_process
def:
  "The transfer of information from one cell to another, where the signal travels from the signal-producing cell to the receiving cell by passive diffusion or bulk flow in intercellular fluid. The signaling cell and the receiving cell are usually in the vicinity of each other." [GOC:mtg_signaling_feb11, ISBN:3527303782]


id: GO:0038002
name: endocrine signaling
namespace: biological_process
def:
  "The transfer of information from one cell to another, where an endocrine hormone is transported from the signal-producing cell to the receiving cell via the circulatory system (via blood, lymph or cerebrospinal fluid). The signaling cell and the receiving cell are often distant to each other." [GOC:mtg_signaling_feb11, ISBN:0199264678, ISBN:3527303782]


id: GO:0038003
name: opioid receptor signaling pathway
namespace: biological_process
def:
  "The series of molecular signals generated as a consequence of an opioid receptor binding to one of its physiological ligands." [GOC:bf, PMID:20494127]


id: GO:0038004
name: epidermal growth factor receptor ligand maturation
namespace: biological_process
def:
  "Any process leading to the attainment of the full functional capacity of a ligand for an epidermal growth factor receptor. The ligand is functional when it can bind to and activate an epidermal growth factor receptor." [GOC:signaling, PMID:11672524]


id: GO:0038005
name: peptide bond cleavage involved in epidermal growth factor receptor ligand maturation
namespace: biological_process
def:
  "The hydrolysis of a peptide bond or bonds within a ligand for the epidermal growth factor receptor, as part of protein maturation, the process leading to the attainment of the full functional capacity of a protein. In Drosophila for example, in the Golgi apparatus of the signal producing cell, Spitz is cleaved within its transmembrane domain to release a functional soluble extracellular fragment." [GOC:signaling, PMID:11672524, PMID:11672525]


id: GO:0038006
name: netrin receptor activity involved in chemoattraction
namespace: molecular_function
def:
  "Combining with a netrin signal and transmitting the signal from one side of the membrane to the other to contribute to the directed movement of a motile cell towards a higher concentration of netrin." [GOC:signaling]


id: GO:0038007
name: netrin-activated signaling pathway
namespace: biological_process
def:
  "A series of molecular events initiated by the binding of a netrin protein to a receptor on the surface of the target cell, and ending with regulation of a downstream cellular process, e.g. transcription. Netrins can act as chemoattractant signals for some cells and chemorepellent signals for others. Netrins also have roles outside of cell and axon guidance." [GOC:signaling, PMID:10399919, PMID:15960985, PMID:19785719, PMID:20108323]


id: GO:0038008
name: TRAF-mediated signal transduction
namespace: biological_process
def:
  "The intracellular process in which a signal is passed on to downstream components within the cell via a tumor necrosis factor receptor-associated factor (TRAF). TRAFs are directly or indirectly recruited to the intracellular domains of cell surface receptors, and engage other signaling proteins to transfer the signal from a cell surface receptor to other intracellular signaling components." [GOC:bf, PMID:19918944, PMID:20596822]


id: GO:0038009
name: regulation of signal transduction by receptor internalization
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of signal transduction by the movement of a signaling receptor from the plasma membrane to the inside of the cell. Receptor internalization can have a positive or negative effect on a signaling pathway." [GOC:bf, GOC:signaling, PMID:17011816, PMID:19696798]


id: GO:0038010
name: positive regulation of signal transduction by receptor internalization
namespace: biological_process
def:
  "Any process in which the internalization of a signaling receptor activates or increases the frequency, rate or extent of signal transduction. Receptor internalization can enhance signaling by concentrating signaling molecules in one location, or by moving a ligand-activated receptor to the location of downstream signaling proteins. Endosomes for example can serve as important intracellular signaling platforms." [GOC:bf, GOC:signaling, PMID:17908284, PMID:19696798]


id: GO:0038011
name: negative regulation of signal transduction by receptor internalization
namespace: biological_process
def:
  "Any process in which internalization of a signaling receptor stops, prevents, or reduces the frequency, rate or extent of signal transduction. Receptor internalization can attenuate or reduce the strength of signaling by reducing the concentration of cell surface receptors available to ligands." [GOC:bf, GOC:signaling, PMID:17908284, PMID:19696798]


id: GO:0038012
name: negative regulation of Wnt signaling pathway by Wnt receptor internalization
namespace: biological_process
def:
  "Any process in which internalization of a Wnt receptor stops, prevents, or reduces the frequency, rate or extent of Wnt signal transduction." [GOC:bf, GOC:BHF, GOC:rl, PMID:17908284, PMID:19643732]


id: GO:0038013
name: positive regulation of Wnt signaling pathway by Wnt receptor internalization
namespace: biological_process
def:
  "Any process in which internalization of a Wnt receptor activates or increases the frequency, rate or extent of the Wnt signaling pathway." [GOC:bf, GOC:signaling, PMID:17908284]


id: GO:0038014
name: negative regulation of insulin receptor signaling pathway by insulin receptor internalization
namespace: biological_process
def:
  "Any process in which internalization of an insulin receptor stops, prevents, or reduces the frequency, rate or extent of insulin receptor signal transduction. Internalization of insulin in association with its receptor clears insulin from the circulation and is necessary for subsequent insulin dissociation from the receptor and insulin degradation." [GOC:bf, GOC:signaling, PMID:18492485, PMID:7821727, PMID:7978876, PMID:9609114]


id: GO:0038015
name: positive regulation of insulin receptor signaling pathway by insulin receptor internalization
namespace: biological_process
def:
  "Any process in which internalization of an insulin receptor activates or increases the frequency, rate or extent of the insulin receptor signaling pathway. Endocytosis of activated receptors can concentrate receptors within endosomes and allow the insulin receptor to phosphorylate substrates that are spatially distinct from those accessible at the plasma membrane." [GOC:bf, GOC:signaling, PMID:9609114]


id: GO:0038016
name: insulin receptor internalization
namespace: biological_process
def:
  "A receptor-mediated endocytosis process that results in the movement of an insulin receptor from the plasma membrane to the inside of the cell." [GOC:bf, PMID:3907718, PMID:9609114]


id: GO:0038017
name: Wnt receptor internalization
namespace: biological_process
def:
  "A receptor-mediated endocytosis process that results in the movement of a Wnt receptor from the plasma membrane to the inside of the cell." [GOC:bf, PMID:17908284]


id: GO:0038018
name: Wnt receptor catabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the breakdown of a Wnt receptor. Internalized Wnt receptors can be recycled to the plasma membrane or sorted to lysosomes for protein degradation." [GOC:BHF, GOC:rl, GOC:signaling, PMID:19643732]


id: GO:0038019
name: Wnt receptor recycling
namespace: biological_process
def:
  "The process that results in the return of a Wnt receptor to an active state at the plasma membrane. An active state is when the receptor is ready to receive a Wnt signal. Internalized Wnt receptors can be recycled to the plasma membrane or sorted to lysosomes for protein degradation." [GOC:bf, GOC:signaling, PMID:19643732]


id: GO:0038020
name: insulin receptor recycling
namespace: biological_process
def:
  "The process that results in the return of an insulin receptor to an active state at the plasma membrane. An active state is when the receptor is ready to receive an insulin signal. Internalized insulin receptors can be recycled to the plasma membrane or sorted to lysosomes for protein degradation." [GOC:bf, GOC:signaling, PMID:3907718]


id: GO:0038021
name: leptin receptor activity
namespace: molecular_function
def:
  "Combining with the fat-cell specific hormone leptin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:bf, GOC:signaling, PMID:9102398, Wikipedia:Leptin_receptor]


id: GO:0038022
name: G-protein coupled olfactory receptor activity
namespace: molecular_function
def:
  "Combining with an odorant and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, GOC:sart, PMID:21041441]


id: GO:0038023
name: signaling receptor activity
namespace: molecular_function
def:
  "Receiving a signal and transmitting the signal in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:bf, GOC:signaling]


id: GO:0038024
name: cargo receptor activity
namespace: molecular_function
def:
  "Combining selectively with an extracellular substance and delivering the substance into the cell via endocytosis." [GOC:bf, GOC:signaling, PMID:15239958]


id: GO:0038025
name: reelin receptor activity
namespace: molecular_function
def:
  "Combining with the secreted glycoprotein reelin, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:bf, PMID:12827279, PMID:20223215, PR:000013879]


id: GO:0038026
name: reelin-mediated signaling pathway
namespace: biological_process
def:
  "A series of molecular signals initiated by the binding of reelin (a secreted glycoprotein) to a receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, PMID:12827279, PMID:20223215, PR:000013879]


id: GO:0038027
name: apolipoprotein A-I-mediated signaling pathway
namespace: biological_process
def:
  "A series of molecular signals initiated by the binding of apolipoprotein A-I to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:signaling, PMID:16443932]


id: GO:0038028
name: insulin receptor signaling pathway via phosphatidylinositol 3-kinase
namespace: biological_process
def:
  "The series of molecular signals generated as a consequence of the insulin receptor binding to its physiological ligand, where the signal is passed on via the phosphatidylinositol 3-kinase cascade." [GOC:bf, GOC:signaling, PMID:19322168, PMID:20696212]


id: GO:0038029
name: epidermal growth factor receptor signaling pathway via MAPK cascade
namespace: biological_process
def:
  "The series of molecular signals generated as a consequence of an epidermal growth factor receptor binding to one of its physiological ligands, where the signal is passed on via the MAPKKK cascade." [GOC:bf, GOC:signaling, PMID:21167805]


id: GO:0038030
name: non-canonical Wnt signaling pathway via MAPK cascade
namespace: biological_process
def:
  "The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, where the signal is passed on via the MAPKKK cascade." [GOC:BHF, GOC:signaling, GOC:vk, PMID:17720811]


id: GO:0038031
name: non-canonical Wnt signaling pathway via JNK cascade
namespace: biological_process
def:
  "The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, where the signal is passed on via the JNK cascade." [GOC:BHF, GPC:rl, PMID:19137009, PMID:20032469]


id: GO:0038032
name: termination of G-protein coupled receptor signaling pathway
namespace: biological_process
def:
  "The signaling process in which G-protein coupled receptor signaling is brought to an end. For example, through the action of GTPase-activating proteins (GAPs) that act to accelerate hydrolysis of GTP to GDP on G-alpha proteins, thereby terminating the transduced signal." [GOC:bf, GOC:signaling]


id: GO:0038033
namespace: biological_process
name:
  positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway

def:
  "A series of molecular signals initiated by the binding of a vascular endothelial growth factor (VEGF) to a VEGFR on the surface of a cell, which activates or increases the frequency, rate or extent of endothelial cell chemotaxis." [GOC:bf, GOC:BHF, GOC:rl, PMID:21245381]


id: GO:0038034
name: signal transduction in absence of ligand
namespace: biological_process
def:
  "A series of molecular signals initiated by the absence of a ligand or the withdrawal of a ligand from a receptor." [GOC:al, GOC:ppm, GOC:pr, PMID:15044679]


id: GO:0038035
name: G-protein coupled receptor signaling in absence of ligand
namespace: biological_process
def:
  "A series of molecular signals beginning with a G-protein coupled receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex, where the G-protein coupled receptor is not bound to an agonist." [GOC:al, PMID:12402500, PMID:17629961]


id: GO:0038036
name: sphingosine-1-phosphate receptor activity
namespace: molecular_function
def:
  "Combining with the sphingolipid sphingosine-1-phosphate (S1P), and transmitting the signal across the membrane by activating an associated G-protein." [GOC:bf, PMID:12728273, Wikipedia:S1PR1]


id: GO:0038038
name: G-protein coupled receptor homodimeric complex
namespace: cellular_component
def:
  "A protein complex that contains two G-protein coupled receptors (GPCRs) of the same subtype. Formation of a GPCR homodimer may be important for the transport of newly formed receptors to the cell surface, and the function of the receptor." [GOC:al, GOC:bf, PMID:10713101, PMID:16670762]


id: GO:0038039
name: G-protein coupled receptor heterodimeric complex
namespace: cellular_component
def:
  "A protein complex that contains two G-protein coupled receptors (GPCRs) of different subtypes. Formation of a GPCR heterodimer may alter the functional property of the GPCR." [GOC:al, GOC:bf, PMID:16109836, PMID:20150590]


id: GO:0038040
name: cross-receptor activation within G-protein coupled receptor heterodimer
namespace: biological_process
def:
  "Activation of one protomer of a G-protein coupled receptor (GPCR) heterodimer by the associated subunit. For example, agonist occupancy in one protomer of a GPCR dimer may activate the associated promoter." [GOC:al, GOC:bf, PMID:21063387]


id: GO:0038041
name: cross-receptor inhibition within G-protein coupled receptor heterodimer
namespace: biological_process
def:
  "Inhibition of one protomer of a G-protein coupled receptor (GPCR) heterodimer by the associated subunit. For example, agonist activation of one cytokine receptor can prevent activation of its associated cytokine receptor subunit." [GOC:al, GOC:bf, PMID:15979374]


id: GO:0038042
name: dimeric G-protein coupled receptor signaling pathway
namespace: biological_process
def:
  "A series of molecular signals initiated by an extracellular signal combining with a dimeric receptor on the surface of the target cell, and proceeding with the activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. Heterodimeric and homodimeric GPCRs may have different functional properties from those of the respective monomers." [GOC:al, GOC:bf, PMID:15979374, PMID:21063387]


id: GO:0038043
name: interleukin-5-mediated signaling pathway
namespace: biological_process
def:
  "A series of molecular signals initiated by the binding of interleukin-5 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:pg, GOC:signaling, PR:000001392]


id: GO:0038044
name: transforming growth factor-beta secretion
namespace: biological_process
def:
  "The regulated release of transforming growth factor-beta (TGF-beta) from a cell into the extracellular region. TGF-beta is mostly secreted as a large latent TGF-beta complex (LLC) containing latency-associated proteins (LAPs) derived from the N-terminal region of the TGF-beta gene product, dimeric TGF-beta and latent TGF-beta binding proteins (LTBPs)." [GOC:bf, GOC:yaf, PMID:2350783, Reactome:REACT_6888.1]


id: GO:0038045
name: large latent transforming growth factor-beta complex
namespace: cellular_component
def:
  "A protein complex containing latency-associated proteins (LAPs), mature disulphide-linked dimeric TGF-beta, and latent TGF-beta binding proteins (LTBPs). TGF-beta is mostly secreted as part of the large latent complex, and must be subsequently released from the LLC in order to bind to cell surface receptors." [GOC:bf, PMID:2350783, PMID:8680476, PMID:9805445, Reactome:REACT_6888.1]


id: GO:0038046
name: enkephalin receptor activity
namespace: molecular_function
def:
  "Combining with an enkephalin, and transmitting the signal across the membrane by activating an associated G-protein. A enkephalin is a pentapeptide (Tyr-Gly-Gly-Phe-Met or Tyr-Gly-Gly-Phe-Leu) involved in regulating nociception in the body." [GOC:bf, Wikipedia:Enkephalin]


id: GO:0038047
name: morphine receptor activity
namespace: molecular_function
def:
  "Combining with morphine (17-methyl-7,8-didehydro-4,5alpha-epoxymorphinan-3,6alpha-diol), and transmitting the signal across the membrane by activating an associated G-protein." [CHEBI:17303, GOC:bf]


id: GO:0038048
name: dynorphin receptor activity
namespace: molecular_function
def:
  "Combining with a dynorphin peptide, and transmitting the signal across the membrane by activating an associated G-protein. Dynorphin is any opioid peptide that is generated by cleavage of the precursor protein prodynorphin." [GOC:bf, Wikipedia:Dynorphin]


id: GO:0038049
name: transcription factor activity, ligand-activated RNA polymerase II transcription factor binding
namespace: molecular_function
def:
  "Combining with a signal and transmitting the signal to the transcriptional machinery by interacting selectively and non-covalently with an RNA polymerase II transcription factor, which may be a single protein or a complex, in order to modulate transcription. For example, some steroid hormone receptors bind to transcription factor complexes to regulate transcription of genes whose promoters do not contain hormone response elements." [GOC:signaling, GOC:txnOH]


id: GO:0038050
namespace: molecular_function
name:
  RNA polymerase II transcription factor activity, glucocorticoid-activated sequence-specific DNA binding

def:
  "Combining with a glucocorticoid and transmitting the signal to the transcriptional machinery by interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription by RNA polymerase II." [GOC:signaling, PMID:17689856]


id: GO:0038051
namespace: molecular_function
name:
  glucocorticoid-activated RNA polymerase II transcription factor binding transcription factor activity

def:
  "Combining with a glucocorticoid and transmitting the signal to the transcriptional machinery by interacting selectively and non-covalently with an RNA polymerase II transcription factor, which may be a single protein or a complex, in order to modulate transcription. For example, glucocorticoid-bound receptors can bind to transcription factor complexes to regulate transcription of genes whose promoters do not contain glucocorticoid response elements." [GOC:signaling, PMID:17689856]


id: GO:0038052
name: RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding
namespace: molecular_function
def:
  "Combining with estrogen and transmitting the signal to the transcriptional machinery by interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription by RNA polymerase II." [GOC:signaling, PMID:17615392]


id: GO:0038053
name: transcription factor activity, estrogen-activated RNA polymerase II transcription factor binding
namespace: molecular_function
def:
  "Combining with estrogen and transmitting the signal to the transcriptional machinery by interacting selectively and non-covalently with an RNA polymerase II transcription factor, which may be a single protein or a complex, in order to modulate transcription. For example, estrogen-bound receptors can bind to transcription factor complexes to regulate transcription of genes whose promoters do not contain estrogen response elements." [GOC:signaling, PMID:17615392]


id: GO:0038054
name: G-protein coupled estrogen receptor activity
namespace: molecular_function
def:
  "Combining with estrogen and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:signaling, PMID:17379646, PMID:20960099]


id: GO:0038055
name: BMP secretion
namespace: biological_process
def:
  "The controlled release of a member of the BMP family of proteins from a cell." [GOC:sart, PR:000000034]


id: GO:0038056
name: negative regulation of BMP signaling pathway by negative regulation of BMP secretion
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of the BMP signaling pathway by stopping, preventing or reducing the frequency, rate or extent of secretion of a member of the BMP family of proteins from the signaling cell." [GOC:bf, GOC:sart, PMID:21750037]


id: GO:0038057
name: TNFSF11 binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with tumor necrosis factor ligand superfamily member 11 (TNFSF11), a member of the tumor necrosis factor (TNF) cytokine family." [GOC:cjm, PR:000002107]


id: GO:0038058
name: TNFSF11 receptor activity
namespace: molecular_function
def:
  "Combining with a tumor necrosis factor ligand superfamily member 11 (TNFSF11) and transmitting the signal across the cell membrane to initiate a change in cell activity or function." [GOC:bf, GOC:cjm, PR:000002107]


id: GO:0038059
name: IKKalpha-IKKalpha complex
namespace: cellular_component
def:
  "A homodimeric protein complex containing two IkappaB kinase (IKK) alpha subunits." [GOC:bf, PMID:18626576, PMID:21173796]


id: GO:0038060
name: nitric oxide-cGMP-mediated signaling pathway
namespace: biological_process
def:
  "Any intracellular signal transduction in which the signal is passed on within the cell by nitric oxide (NO) activating soluble guanylyl cyclase (sGC). Includes synthesis of nitric oxide, guanylyl cyclase activity, and downstream effectors that further transmit the signal within the cell following activation by cGMP." [GOC:signaling, PMID:21549190, PMID:22019632]


id: GO:0038061
name: NIK/NF-kappaB signaling
namespace: biological_process
def:
  "The process in which a signal is passed on to downstream components within the cell through the NIK-dependent processing and activation of NF-KappaB. Begins with activation of the NF-KappaB-inducing kinase (NIK), which in turn phosphorylates and activates IkappaB kinase alpha (IKKalpha). IKKalpha phosphorylates the NF-Kappa B2 protein (p100) leading to p100 processing and release of an active NF-KappaB (p52)." [GOC:bf, GOC:mg2, GOC:signaling, GOC:vs, PMID:11239468, PMID:15140882]


id: GO:0038062
name: protein tyrosine kinase collagen receptor activity
namespace: molecular_function
def:
  "Combining with collagen and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate." [GOC:bf, GOC:uh, PMID:16626936, PMID:21568710]


id: GO:0038063
name: collagen-activated tyrosine kinase receptor signaling pathway
namespace: biological_process
def:
  "A series of molecular signals initiated by the binding of collagen to a receptor on the surface of the target cell where the receptor possesses tyrosine kinase activity. The pathway ends with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:uh, PMID:15888913, PMID:16626936]


id: GO:0038064
name: collagen receptor activity
namespace: molecular_function
def:
  "Combining with a collagen and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:bf, GOC:uh, PMID:21568710]


id: GO:0038065
name: collagen-activated signaling pathway
namespace: biological_process
def:
  "A series of molecular signals initiated by collagen binding to a cell surface receptor, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:uh, PMID:21568710]


id: GO:0038066
name: p38MAPK cascade
namespace: biological_process
def:
  "An intracellular protein kinase cascade containing at least a p38 MAPK, a MAPKK and a MAP3K. The cascade can also contain two additional tiers: the upstream MAP4K and the downstream MAP Kinase-activated kinase (MAPKAPK). The kinases in each tier phosphorylate and activate the kinases in the downstream tier to transmit a signal within a cell." [GOC:signaling, PMID:20811974]


id: GO:0038067
name: MAP kinase activity involved in cell wall organization or biogenesis
namespace: molecular_function
def:
  "Catalysis of the reaction: protein + ATP = protein phosphate + ADP by a mitogen-activated protein kinase, as part of a MAPK signaling cascade that contributes to cell wall organization or biogenesis." [GOC:signaling]


id: GO:0038068
name: MAP kinase kinase activity involved in cell wall organization or biogenesis
namespace: molecular_function
def:
  "Catalysis of the concomitant phosphorylation of threonine (T) and tyrosine (Y) residues in a Thr-Glu-Tyr (TEY) thiolester sequence in a MAP kinase (MAPK) substrate, as part of a MAPK signaling cascade that contributes to cell wall organization or biogenesis." [GOC:signaling]


id: GO:0038069
name: MAP kinase phosphatase activity involved in regulation of cell wall biogenesis
namespace: molecular_function
def:
  "Catalysis of the reaction: a phosphorylated MAP kinase + H2O = a MAP kinase + phosphate, where the MAP kinase (MAPK) is part of a MAPK signaling cascade that contributes to cell wall biogenesis." [GOC:signaling]


id: GO:0038070
name: MAP kinase kinase kinase activity involved in cell wall organization or biogenesis
namespace: molecular_function
def:
  "Catalysis of the phosphorylation and activation of a MAP kinase kinase (MAPKK), as part of a MAPK signaling cascade that contributes to cell wall organization or biogenesis." [GOC:signaling]


id: GO:0038071
name: MAP kinase activity involved in conjugation with cellular fusion
namespace: molecular_function
def:
  "Catalysis of the reaction: protein + ATP = protein phosphate + ADP by a mitogen-activated protein kinase, as part of a MAPK signaling cascade that contributes to conjugation with cellular fusion." [GOC:signaling]


id: GO:0038072
name: MAP kinase kinase activity involved in conjugation with cellular fusion
namespace: molecular_function
def:
  "Catalysis of the concomitant phosphorylation of threonine (T) and tyrosine (Y) residues in a Thr-Glu-Tyr (TEY) thiolester sequence in a MAP kinase (MAPK) substrate, as part of a MAPK signaling cascade that contributes to conjugation with cellular fusion." [GOC:signaling]


id: GO:0038073
name: MAP kinase kinase kinase activity involved in conjugation with cellular fusion
namespace: molecular_function
def:
  "Catalysis of the phosphorylation and activation of a MAP kinase kinase (MAPKK), as part of a MAPK signaling cascade that contributes to cell wall biogenesis." [GOC:signaling]


id: GO:0038074
name: MAP kinase phosphatase activity involved in regulation of conjugation with cellular fusion
namespace: molecular_function
def:
  "Catalysis of the reaction: a phosphorylated MAP kinase + H2O = a MAP kinase + phosphate, where the MAP kinase (MAPK) is part of a MAPK signaling cascade that contributes to conjugation with cellular fusion." [GOC:signaling]


id: GO:0038075
name: MAP kinase activity involved in innate immune response
namespace: molecular_function
def:
  "Catalysis of the reaction: protein + ATP = protein phosphate + ADP by a mitogen-activated protein kinase, as part of a MAPK signaling cascade that contributes to an innate immune response." [GOC:signaling]


id: GO:0038076
name: MAP kinase kinase activity involved in innate immune response
namespace: molecular_function
def:
  "Catalysis of the concomitant phosphorylation of threonine (T) and tyrosine (Y) residues in a Thr-Glu-Tyr (TEY) thiolester sequence in a MAP kinase (MAPK) substrate, as part of a MAPK signaling cascade that contributes to an innate immune response." [GOC:signaling]


id: GO:0038077
name: MAP kinase kinase kinase activity involved in innate immune response
namespace: molecular_function
def:
  "Catalysis of the phosphorylation and activation of a MAP kinase kinase (MAPKK), as part of a MAPK signaling cascade that contributes to an innate immune response." [GOC:signaling]


id: GO:0038078
name: MAP kinase phosphatase activity involved in regulation of innate immune response
namespace: molecular_function
def:
  "Catalysis of the reaction: a phosphorylated MAP kinase + H2O = a MAP kinase + phosphate, where the MAP kinase (MAPK) is part of a MAPK signaling cascade that contributes to an innate immune response." [GOC:signaling]


id: GO:0038079
name: MAP kinase activity involved in osmosensory signaling pathway
namespace: molecular_function
def:
  "Catalysis of the reaction: protein + ATP = protein phosphate + ADP by a mitogen-activated protein kinase, as part of a MAPK signaling cascade that passes on a signal within an osmosensory signaling pathway." [GOC:signaling]


id: GO:0038080
name: MAP kinase kinase activity involved in osmosensory signaling pathway
namespace: molecular_function
def:
  "Catalysis of the concomitant phosphorylation of threonine (T) and tyrosine (Y) residues in a Thr-Glu-Tyr (TEY) thiolester sequence in a MAP kinase (MAPK) substrate, as part of a MAPK signaling cascade that passes on a signal within an osmosensory signaling pathway." [GOC:signaling]


id: GO:0038081
name: MAP kinase kinase kinase activity involved in osmosensory signaling pathway
namespace: molecular_function
def:
  "Catalysis of the phosphorylation and activation of a MAP kinase kinase (MAPKK), as part of a MAPK signaling cascade that passes on a signal within an osmosensory signaling pathway." [GOC:signaling]


id: GO:0038082
name: MAP kinase phosphatase activity involved in regulation of osmosensory signaling pathway
namespace: molecular_function
def:
  "Catalysis of the reaction: a phosphorylated MAP kinase + H2O = a MAP kinase + phosphate, where the MAP kinase (MAPK) is part of a MAPK signaling cascade that passes on a signal within an osmosensory signaling pathway." [GOC:signaling]


id: GO:0038083
name: peptidyl-tyrosine autophosphorylation
namespace: biological_process
def:
  "The phosphorylation by a protein of one or more of its own tyrosine amino acid residues, or a tyrosine residue on an identical protein." [PMID:10037737, PMID:10068444, PMID:10940390]


id: GO:0038084
name: vascular endothelial growth factor signaling pathway
namespace: biological_process
def:
  "A series of molecular signals initiated by the binding of a vascular endothelial growth factor (VEGF) to a receptor on the surface of the target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:signaling, PMID:17470632, PR:000003096, PR:000007520, PR:000017284, PR:000017285]


id: GO:0038085
name: vascular endothelial growth factor binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with a vascular endothelial growth factor." [PMID:17470632, PR:000003096, PR:000007520, PR:000017284, PR:000017285]


id: GO:0038086
name: VEGF-activated platelet-derived growth factor receptor signaling pathway
namespace: biological_process
def:
  "A series of molecular signals initiated by the binding of a vascular endothelial growth factor (VEGF) to a platelet-derived growth factor receptor (PDGFR) on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:signaling, PMID:17470632]


id: GO:0038087
name: VEGF-activated platelet-derived growth factor receptor-alpha signaling pathway
namespace: biological_process
def:
  "A series of molecular signals initiated by the binding of a vascular endothelial growth factor (VEGF) to an alpha-type platelet-derived growth factor receptor (PDGFR) on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:signaling, PMID:17470632]


id: GO:0038088
name: VEGF-activated platelet-derived growth factor receptor-beta signaling pathway
namespace: biological_process
def:
  "A series of molecular signals initiated by the binding of a vascular endothelial growth factor (VEGF) to a beta-type platelet-derived growth factor receptor (PDGFR) on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:signaling, PMID:17470632]


id: GO:0038089
name: positive regulation of cell migration by vascular endothelial growth factor signaling pathway
namespace: biological_process
def:
  "A series of molecular signals initiated by the binding of a vascular endothelial growth factor (VEGF) to a receptor on the surface of a cell, which activates or increases the frequency, rate or extent of the orderly movement of a cell from one site to another." [GOC:bf, GOC:signaling, PR:000003096, PR:000017284, PR:000017285]


id: GO:0038090
namespace: biological_process
name:
  positive regulation of cell migration by VEGF-activated platelet derived growth factor receptor signaling pathway

def:
  "A series of molecular signals initiated by the binding of a vascular endothelial growth factor (VEGF) to a platelet-derived growth factor receptor (PDGFR) on the surface of a cell, which activates or increases the frequency, rate or extent of the orderly movement of a cell from one site to another." [GOC:bf, GOC:signaling, PMID:17470632]


id: GO:0038091
namespace: biological_process
name:
  positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway

def:
  "A series of molecular signals initiated by the binding of a vascular endothelial growth factor (VEGF) to a platelet-derived growth factor receptor (PDGFR) on the surface of a cell, which activates or increases the frequency, rate or extent of cell proliferation." [GOC:signaling, PMID:17470632]


id: GO:0038092
name: nodal signaling pathway
namespace: biological_process
def:
  "A series of molecular signals initiated by the binding of a nodal protein to an activin receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:BHF, GOC:vk, PMID:17287255]


id: GO:0038093
name: Fc receptor signaling pathway
namespace: biological_process
def:
  "A series of molecular signals initiated by the binding of the Fc portion of an immunoglobulin to an Fc receptor on the surface of a signal-receiving cell, and ending with regulation of a downstream cellular process, e.g. transcription. The Fc portion of an immunoglobulin is its C-terminal constant region." [GOC:phg, Wikipedia:Fc_receptor]


id: GO:0038094
name: Fc-gamma receptor signaling pathway
namespace: biological_process
def:
  "A series of molecular signals initiated by the binding of the Fc portion of immunoglobulin G (IgG) to an Fc-gamma receptor on the surface of a signal-receiving cell, and ending with regulation of a downstream cellular process, e.g. transcription. The Fc portion of an immunoglobulin is its C-terminal constant region." [GOC:phg, PMID:11244038]


id: GO:0038095
name: Fc-epsilon receptor signaling pathway
namespace: biological_process
def:
  "A series of molecular signals initiated by the binding of the Fc portion of immunoglobulin E (IgE) to an Fc-epsilon receptor on the surface of a signal-receiving cell, and ending with regulation of a downstream cellular process, e.g. transcription. The Fc portion of an immunoglobulin is its C-terminal constant region." [GOC:phg, PMID:12413516, PMID:15048725]


id: GO:0038096
name: Fc-gamma receptor signaling pathway involved in phagocytosis
namespace: biological_process
def:
  "An Fc-gamma receptor signaling pathway that contributes to the endocytic engulfment of external particulate material by phagocytes." [GOC:phg, PMID:12488490, PMID:15466916]


id: GO:0038097
name: positive regulation of mast cell activation by Fc-epsilon receptor signaling pathway
namespace: biological_process
def:
  "An Fc-epsilon receptor signaling pathway that results in the change in morphology and behavior of a mast cell resulting from exposure to a cytokine, chemokine, soluble factor, or to (at least in mammals) an antigen which the mast cell has specifically bound via IgE bound to Fc-epsilonRI receptors." [GOC:phg, PMID:12413516]


id: GO:0038098
name: sequestering of BMP from receptor via BMP binding
namespace: biological_process
def:
  "Binding to a bone morphogenetic protein (BMP) in the extracellular region, and inhibiting BMP signaling by preventing BMP from binding to its cell surface receptor." [GOC:bf, GOC:signaling, PMID:19855014]


id: GO:0038099
name: nodal receptor complex assembly
namespace: biological_process
def:
  "The aggregation, arrangement and bonding together of a set of components to form a complex containing a type II activin receptor, a type I activin receptor, and a coreceptor of the EGF-CFC family (e.g. Cripto or Cryptic, in mammals)." [GOC:bf, GOC:signaling, PMID:15062104]


id: GO:0038100
name: nodal binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with a nodal protein, a member of the transforming growth factor-beta superfamily." [GOC:bf, PMID:20629020, PR:000000105]


id: GO:0038101
name: sequestering of nodal from receptor via nodal binding
namespace: biological_process
def:
  "Binding to a nodal protein in the extracellular region, and inhibiting nodal signaling by preventing nodal from binding to its cell surface receptor." [GOC:signaling, PMID:14570583, PMID:15062104]


id: GO:0038102
name: activin receptor antagonist activity
namespace: molecular_function
def:
  "Interacting with an activin receptor complex to reduce the action of another ligand, the agonist. A receptor antagonist does not initiate signaling upon binding to a receptor, but instead blocks an agonist from binding to the receptor." [GOC:signaling, PMID:15062104]


id: GO:0038103
name: activin receptor antagonist activity involved in negative regulation of nodal signaling pathway
namespace: molecular_function
def:
  "Interacting with an activin receptor to reduce the action of the agonist nodal. A receptor antagonist does not initiate signaling upon binding to a receptor, but instead blocks an agonist from binding to the receptor." [GOC:signaling, PMID:15062104]


id: GO:0038104
name: nodal receptor complex
namespace: cellular_component
def:
  "A protein complex containing at least a type II activin receptor, a type I activin receptor, and a coreceptor (EGF-CFC protein) such as Cripto or Cryptic. Nodal receptor complexes are capable of binding a nodal protein and transducing the signal into the cell." [GOC:bf, GOC:signaling, PMID:11024047, PMID:15062104]


id: GO:0038105
name: sequestering of TGFbeta from receptor via TGFbeta binding
namespace: biological_process
def:
  "Binding to a transforming growth factor-beta (TGFbeta) protein in the extracellular region, and inhibiting TGFbeta signaling by preventing TGFbeta from binding to its cell surface receptor." [GOC:bf, GOC:signaling, PMID:19855014]


id: GO:0038106
name: choriogonadotropin hormone binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with choriogonadotropin hormone, a heterodimer, with an alpha subunit identical to that of luteinizing hormone (LH), follicle-stimulating hormone (FSH) and thyroid-stimulating hormone (TSH), and a unique beta subunit." [GOC:BHF, GOC:rl, Wikipedia:Human_chorionic_gonadotropin]


id: GO:0038107
name: nodal signaling pathway involved in determination of left/right asymmetry
namespace: biological_process
def:
  "A series of molecular signals initiated by the binding of a nodal protein to an activin receptor on the surface of a target cell, which contributes to the establishment of an organism's body plan or part of an organism with respect to the left and right halves." [GOC:BHF, GOC:vk, PMID:12857784, PMID:17287255, PMID:20413706]


id: GO:0038108
name: negative regulation of appetite by leptin-mediated signaling pathway
namespace: biological_process
def:
  "A series of molecular signals initiated by the binding of leptin to a receptor on the surface of a cell, which reduces appetite, the desire or physical craving for food." [GOC:BHF, GOC:vk, PMID:19150989]


id: GO:0038109
name: Kit signaling pathway
namespace: biological_process
def:
  "A series of molecular signals that starts with the binding of stem cell factor to the tyrosine kinase receptor KIT on the surface of a cell, and ends with regulation of a downstream cellular process, e.g. transcription. Stem cell factor (KIT ligand) binding to the receptor Kit mediates receptor dimerization, activation of its intrinsic tyrosine kinase activity and autophosphorylation. The activated receptor then phosphorylates various substrates, thereby activating distinct signaling cascades within the cell that trigger a change in state or activity of the cell." [GOC:nhn, GOC:signaling, PMID:16129412]


id: GO:0038110
name: interleukin-2-mediated signaling pathway
namespace: biological_process
def:
  "A series of molecular signals initiated by the binding of interleukin-2 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:nhn, GOC:signaling]


id: GO:0038111
name: interleukin-7-mediated signaling pathway
namespace: biological_process
def:
  "A series of molecular signals initiated by the binding of interleukin-7 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:nhn, GOC:signaling]


id: GO:0038112
name: interleukin-8-mediated signaling pathway
namespace: biological_process
def:
  "A series of molecular signals initiated by the binding of interleukin-8 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:nhn, GOC:signaling]


id: GO:0038113
name: interleukin-9-mediated signaling pathway
namespace: biological_process
def:
  "A series of molecular signals initiated by the binding of interleukin-9 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:nhn, GOC:signaling]


id: GO:0038114
name: interleukin-21-mediated signaling pathway
namespace: biological_process
def:
  "A series of molecular signals initiated by the binding of interleukin-21 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:nhn, GOC:signaling]


id: GO:0038115
name: chemokine (C-C motif) ligand 19 signaling pathway
namespace: biological_process
def:
  "A series of molecular signals initiated by the binding of the C-C chemokine CCL19 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:nhn, GOC:signaling, PMID:15059845, PR:000001991]


id: GO:0038116
name: chemokine (C-C motif) ligand 21 signaling pathway
namespace: biological_process
def:
  "A series of molecular signals initiated by the binding of the C-C chemokine CCL21 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:nhn, GOC:signaling, PMID:15059845, PR:000001993]


id: GO:0038117
name: C-C motif chemokine 19 receptor activity
namespace: molecular_function
def:
  "Combining with the C-C motif chemokine 19 (CCL19) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:signaling, PMID:15059845, PR:000001991]


id: GO:0038118
name: C-C chemokine receptor CCR7 signaling pathway
namespace: biological_process
def:
  "A series of molecular signals initiated by a the C-C chemokine type 7 receptor on the surface of a cell binding to one of it's physiological ligands, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:signaling, PMID:15059845, PMID:15778365, PR:000001203]


id: GO:0038119
name: CCL19-activated CCR7 signaling pathway
namespace: biological_process
def:
  "A series of molecular signals initiated by the binding of the C-C chemokine CCL19 to a C-C chemokine type 7 receptor (CCR7) on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:nhn, GOC:signaling, PMID:15059845, PR:000001203]


id: GO:0038120
name: CCL21-activated CCR7 signaling pathway
namespace: biological_process
def:
  "A series of molecular signals initiated by the binding of the C-C chemokine CCL21 to a C-C chemokine type 7 receptor (CCR7) on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:nhn, GOC:signaling, PMID:15059845, PR:000001203]


id: GO:0038121
name: C-C motif chemokine 21 receptor activity
namespace: molecular_function
def:
  "Combining with the C-C motif chemokine 21 (CCL21) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:signaling, PMID:15059845, PR:000001993]


id: GO:0038122
name: C-C motif chemokine 5 receptor activity
namespace: molecular_function
def:
  "Combining with the C-C motif chemokine 5 (CCL5) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:signaling, PR:000002094]


id: GO:0038123
name: toll-like receptor TLR1:TLR2 signaling pathway
namespace: biological_process
def:
  "A series of molecular signals initiated by the binding of a heterodimeric TLR1:TLR2 complex to one of it's physiological ligands, followed by transmission of the signal by the activated receptor, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:nhn, GOC:signaling, PMID:17318230]


id: GO:0038124
name: toll-like receptor TLR6:TLR2 signaling pathway
namespace: biological_process
def:
  "A series of molecular signals initiated by the binding of a heterodimeric TLR6:TLR2 complex to one of it's physiological ligands, followed by transmission of the signal by the activated receptor, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:nhn, GOC:signaling, PMID:17318230]


id: GO:0038127
name: ERBB signaling pathway
namespace: biological_process
def:
  "A series of molecular signals initiated by binding of a ligand to a member of the ERBB family of receptor tyrosine kinases on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:jc, PMID:16460914, PR:000001812, Wikipedia:ErbB]


id: GO:0038128
name: ERBB2 signaling pathway
namespace: biological_process
def:
  "A series of molecular signals initiated by binding of a ligand to a member of the ERBB family of receptors on the surface of a cell, where the signal is transmitted by ERBB2. The pathway ends with regulation of a downstream cellular process, e.g. transcription. ERBB2 receptors are themselves unable to bind to ligands, but act as a signal-amplifying tyrosine kinase within a heterodimeric pair." [GOC:jc, PMID:16460914, PR:000002082, Reactome:REACT_115755.1]


id: GO:0038129
name: ERBB3 signaling pathway
namespace: biological_process
def:
  "A series of molecular signals initiated by binding of a ligand to the tyrosine kinase receptor ERBB3 on the surface of a cell. The pathway ends with regulation of a downstream cellular process, e.g. transcription. ERBB3 receptors have impaired kinase activity and rely on the kinase activity of the heterodimer partner for activation and signal transmission." [GOC:jc, PMID:16460914, PR:000007159, Reactome:REACT_115637.1]


id: GO:0038130
name: ERBB4 signaling pathway
namespace: biological_process
def:
  "A series of molecular signals initiated by binding of a ligand to the tyrosine kinase receptor ERBB4 on the surface of a cell. The pathway ends with regulation of a downstream cellular process, e.g. transcription." [GOC:jc, PMID:16460914, PR:000007160, Reactome:REACT_115596.2]


id: GO:0038131
name: neuregulin receptor activity
namespace: molecular_function
def:
  "Combining with a neuregulin, a member of the EGF family of growth factors, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:bf, GOC:signaling, PMID:16460914, PMID:20672328]


id: GO:0038132
name: neuregulin binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with a neuregulin, a member of the EGF family of growth factors." [GOC:bf, GOC:signaling]


id: GO:0038133
name: ERBB2-ERBB3 signaling pathway
namespace: biological_process
def:
  "A series of molecular signals initiated by binding of a ligand to a ERBB3 receptor on the surface of a cell, followed by transmission of the signal by a heterodimeric complex of ERBB2 and ERBB3. ERBB2, which does not bind any known ligand, is activated through formation of a heterodimer with another ligand-activated ERBB family member such as ERBB3. ERBB3 also has impaired kinase activity and relies on ERBB2 for activation and signal transmission." [GOC:signaling, PMID:16460914, Reactome:REACT_115761.1]


id: GO:0038134
name: ERBB2-EGFR signaling pathway
namespace: biological_process
def:
  "A series of molecular signals initiated by binding of a ligand to an epidermal growth factor receptor (EGFR/ERBB1) on the surface of a cell, followed by transmission of the signal by a heterodimeric complex of ERBB2 and EGFR. ERBB2, which does not bind any known ligand, is activated through formation of a heterodimer with another ligand-activated ERBB family member such as EGFR." [GOC:signaling, PMID:16460914, Reactome:REACT_115761.1]


id: GO:0038135
name: ERBB2-ERBB4 signaling pathway
namespace: biological_process
def:
  "A series of molecular signals initiated by binding of a ligand to a ERBB4 receptor on the surface of a cell, followed by transmission of the signal by a heterodimeric complex of ERBB2 and ERBB4. ERBB2, which does not bind any known ligand, is activated through formation of a heterodimer with another ligand-activated ERBB family member such as ERBB4." [GOC:signaling, PMID:16460914, Reactome:REACT_115761.1]


id: GO:0038136
name: ERBB3-ERBB4 signaling pathway
namespace: biological_process
def:
  "A series of molecular signals transmitted by a heterodimeric complex of the tyrosine kinase receptors ERBB3 and ERBB4. The pathway begins with binding of a ligand to either cell surface receptor, or the dimeric receptor complex, and ends with regulation of a downstream cellular process, e.g. transcription." [GOC:signaling, PMID:16460914, Reactome:REACT_115947.1]


id: GO:0038137
name: ERBB4-EGFR signaling pathway
namespace: biological_process
def:
  "A series of molecular signals transmitted by a heterodimeric complex of the tyrosine kinase receptors EGFR (epidermal growth factor receptor/ERBB1) and ERBB4. The pathway begins with binding of a ligand to either cell surface receptor, or the dimeric receptor complex, and ends with regulation of a downstream cellular process, e.g. transcription." [GOC:signaling, PMID:16460914, Reactome:REACT_116135.1]


id: GO:0038138
name: ERBB4-ERBB4 signaling pathway
namespace: biological_process
def:
  "A series of molecular signals initiated by binding of a ligand to the tyrosine kinase receptor ERBB4, followed by ligand-induced homodimerization of ERBB4 and transmission of the signal into the cell by the homodimeric ERBB4 complex. The pathway ends with regulation of a downstream cellular process, e.g. transcription." [GOC:signaling, PMID:16460914, Reactome:REACT_115969.2]


id: GO:0038139
name: ERBB4-EGFR complex
namespace: cellular_component
def:
  "A heterodimeric complex between the tyrosine kinase receptors ERBB4 (also called HER4) and epidermal growth factor receptor (EGFR/ERBB1)." [GOC:signaling, PMID:16460914, Reactome:REACT_116654.1]


id: GO:0038140
name: ERBB4-ERBB3 complex
namespace: cellular_component
def:
  "A heterodimeric complex between the tyrosine kinase receptors ERBB4 (also called HER4) and ERBB3 (also called HER3). ERBB3 has impaired kinase activity so relies on the kinase activity of its heterodimer partner for activation and signal transmission." [GOC:signaling, PMID:16460914, Reactome:REACT_117805.1]


id: GO:0038141
name: ERBB4-ERBB4 complex
namespace: cellular_component
def:
  "A homodimeric complex containing two monomers of the tyrosine kinase receptor ERBB4 (also called HER4)." [GOC:signaling, PMID:16460914, Reactome:REACT_117065.1]


id: GO:0038142
name: EGFR:ERBB2 complex
namespace: cellular_component
def:
  "A heterodimeric complex between the tyrosine kinase receptor ERBB2 and a ligand-activated epidermal growth factor receptor (EGFR/ERBB1). ERBB2, which does not bind any known ligand, is activated through formation of a heterodimer with another ligand-activated ERBB family member such as EGFR." [GOC:signaling, PMID:16460914, PMID:1973074, Reactome:REACT_115761.1, Reactome:REACT_116379.1, Reactome:REACT_117594.1]


id: GO:0038143
name: ERBB3:ERBB2 complex
namespace: cellular_component
def:
  "A heterodimeric complex between the tyrosine kinase receptor ERBB2 and a ligand-activated receptor ERBB3. ERBB2, which does not bind any known ligand, is activated through formation of a heterodimer with another ligand-activated ERBB family member such as ERBB3." [GOC:signaling, PMID:16460914, PMID:8665853, Reactome:REACT_115761.1, Reactome:REACT_116379.1, Reactome:REACT_117748.1]


id: GO:0038144
name: ERBB4:ERBB2 complex
namespace: cellular_component
def:
  "A heterodimeric complex between the tyrosine kinase receptor ERBB2 and a ligand-activated receptor ERBB4. ERBB2, which does not bind any known ligand, is activated through formation of a heterodimer with another ligand-activated ERBB family member such as ERBB4." [GOC:signaling, PMID:16460914, PMID:16978839, Reactome:REACT_115761.1, Reactome:REACT_116375.1, Reactome:REACT_116379.1]


id: GO:0038145
name: macrophage colony-stimulating factor signaling pathway
namespace: biological_process
def:
  "A series of molecular signals initiated by the binding of the cytokine macrophage colony-stimulating factor (M-CSF) to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:signaling, GOC:uh, PMID:12138890, PR:000005930, Wikipedia:Macrophage_colony-stimulating_factor]


id: GO:0038146
name: chemokine (C-X-C motif) ligand 12 signaling pathway
namespace: biological_process
def:
  "A series of molecular signals initiated by the binding of the chemokine CXCL12 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:nhn, GOC:signaling, PR:000006066, Wikipedia:Stromal_cell-derived_factor-1]


id: GO:0038147
name: C-X-C motif chemokine 12 receptor activity
namespace: molecular_function
def:
  "Combining with the C-X-C motif chemokine 12 (CXCL12) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:bf, PMID:22204316]


id: GO:0038148
name: chemokine (C-C motif) ligand 2 signaling pathway
namespace: biological_process
def:
  "A series of molecular signals initiated by the binding of the C-C chemokine CCL2 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:nhn, GOC:signaling, PR:000002122, Wikipedia:CCL2]


id: GO:0038149
name: C-C motif chemokine 2 receptor activity
namespace: molecular_function
def:
  "Combining with the C-C motif chemokine 2 (CCL2) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:bf, GOC:signaling]


id: GO:0038150
name: C-C chemokine receptor CCR2 signaling pathway
namespace: biological_process
def:
  "A series of molecular signals initiated by a the C-C chemokine type 2 receptor (CCR2) on the surface of a cell binding to one of it's physiological ligands, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:nhn, GOC:signaling, PR:000001199]


id: GO:0038151
name: CCL2-activated CCR2 signaling pathway
namespace: biological_process
def:
  "A series of molecular signals initiated by the binding of the C-C chemokine CCL2 to a C-C chemokine type 2 receptor (CCR2) on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:nhn, GOC:signaling]


id: GO:0038152
name: C-C chemokine receptor CCR4 signaling pathway
namespace: biological_process
def:
  "A series of molecular signals initiated by a the C-C chemokine type 2 receptor (CCR4) on the surface of a cell binding to one of it's physiological ligands, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:nhn, GOC:signaling, PR:000001200]


id: GO:0038153
name: CCL2-activated CCR4 signaling pathway
namespace: biological_process
def:
  "A series of molecular signals initiated by the binding of the C-C chemokine CCL2 to a C-C chemokine type 4 receptor (CCR4) on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:nhn, GOC:signaling]


id: GO:0038154
name: interleukin-11-mediated signaling pathway
namespace: biological_process
def:
  "A series of molecular signals initiated by the binding of interleukin-11 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:nhn, GOC:signaling]


id: GO:0038155
name: interleukin-23-mediated signaling pathway
namespace: biological_process
def:
  "A series of molecular signals initiated by the binding of interleukin-23 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:nhn, GOC:signaling]


id: GO:0038156
name: interleukin-3-mediated signaling pathway
namespace: biological_process
def:
  "A series of molecular signals initiated by the binding of interleukin-3 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:nhn, GOC:signaling]


id: GO:0038157
name: granulocyte-macrophage colony-stimulating factor signaling pathway
namespace: biological_process
def:
  "A series of molecular signals initiated by the binding of the cytokine granulocyte macrophage colony-stimulating factor (GM-CSF) to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. GM-CSF binds to a heterodimer receptor (CSF2R) consisting of an alpha ligand-binding subunit, and a common beta subunit that is shared with other cytokine receptors." [GOC:nhn, GOC:signaling, PMID:17027509]


id: GO:0038158
name: granulocyte colony-stimulating factor signaling pathway
namespace: biological_process
def:
  "A series of molecular signals initiated by the binding of the cytokine granulocyte colony-stimulating factor (G-CSF) to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. G-CSF binds to the receptor (CSF3R)." [GOC:nhn, GOC:signaling]


id: GO:0038159
name: C-X-C chemokine receptor CXCR4 signaling pathway
namespace: biological_process
def:
  "A series of molecular signals initiated by a the C-X-C chemokine type 4 receptor on the surface of a cell binding to one of it's physiological ligands, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:nhn, GOC:signaling]


id: GO:0038160
name: CXCL12-activated CXCR4 signaling pathway
namespace: biological_process
def:
  "A series of molecular signals initiated by the binding of the C-X-C chemokine CXCL12 to a C-X-C chemokine type 4 receptor (CXCR4) on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:nhn]


id: GO:0038161
name: prolactin signaling pathway
namespace: biological_process
def:
  "A series of molecular signals initiated by the binding of the peptide hormone prolactin to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:nhn, GOC:signaling, PMID:21664429]


id: GO:0038162
name: erythropoietin-mediated signaling pathway
namespace: biological_process
def:
  "A series of molecular signals initiated by the binding of erythropoietin (EPO) to the erythropoietin receptor (EPO-R) on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:nhn, PMID:12489509]


id: GO:0038163
name: thrombopoietin-mediated signaling pathway
namespace: biological_process
def:
  "A series of molecular signals initiated by the binding of a thrombopoietin to the thrombopoietin receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:nhn, GOC:signaling, PMID:19630807]


id: GO:0038164
name: thrombopoietin receptor activity
namespace: molecular_function
def:
  "Combining with the glycoprotein thrombopoietin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:bf, GOC:signaling, PMID:19630807]


id: GO:0038165
name: oncostatin-M-mediated signaling pathway
namespace: biological_process
def:
  "A series of molecular signals initiated by the binding of oncostatin-M (OSM) to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. OSM can signal via at least two different receptors (a specific receptor and a LIF receptor) to activate different downstream signal transduction pathways." [GOC:nhn, GOC:signaling, PMID:10579456, PMID:12811586]


id: GO:0038166
name: angiotensin-activated signaling pathway
namespace: biological_process
def:
  "The series of molecular signals generated as a consequence of angiotensin II binding to an angiotensin receptor on the surface of the cell, and proceeding with the activated receptor transmitting the signal to a heterotrimeric G-protein complex to initiate a change in cell activity. Ends with regulation of a downstream cellular process, e.g. transcription." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:nhn, GOC:signaling, PMID:10977869]


id: GO:0038167
namespace: biological_process
name:
  epidermal growth factor receptor signaling pathway via positive regulation of NF-kappaB transcription factor activity

def:
  "The series of molecular signals generated as a consequence of an epidermal growth factor receptor binding to one of its physiological ligands, where the signal is passed on within the cell via activation of the transcription factor NF-kappaB." [GOC:signaling, GOC:uh, PMID:21229383, PMID:21518868, PMID:22132240]


id: GO:0038168
name: epidermal growth factor receptor signaling pathway via I-kappaB kinase/NF-kappaB cascade
namespace: biological_process
def:
  "The series of molecular signals generated as a consequence of an epidermal growth factor receptor binding to one of its physiological ligands, where the signal is passed on within the cell via I-kappaB-kinase (IKK)-dependent activation of the transcription factor NF-kappaB." [GOC:bf, PMID:22132240]


id: GO:0038169
name: somatostatin receptor signaling pathway
namespace: biological_process
def:
  "The series of molecular signals generated as a consequence of a somatostatin receptor (SSTR) binding to one of its physiological ligands and transmitting the signal to a heterotrimeric G-protein complex. The pathway ends with regulation of a downstream cellular process, e.g. transcription." [GOC:jc, PMID:18006219, PMID:8769369, PR:000001555]


id: GO:0038170
name: somatostatin signaling pathway
namespace: biological_process
def:
  "The series of molecular signals generated as a consequence of the peptide somatostatin (SST) binding to a somatostatin receptor (SSTR). The pathway proceeds with the receptor transmitting the signal to a heterotrimeric G-protein complex and ends with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:nhn, GOC:signaling, PMID:18006219, Wikipedia:Somatostatin]


id: GO:0038171
name: cannabinoid signaling pathway
namespace: biological_process
def:
  "The series of molecular signals generated as a consequence of a cannabinoid binding to a cell surface receptor. The pathway proceeds with the receptor transmitting the signal to a heterotrimeric G-protein complex and ends with regulation of a downstream cellular process, e.g. transcription. Cannabinoids are a class of diverse chemical compounds that include the endocannabinoids and the phytocannabinoids." [GOC:bf, GOC:jc, GOC:signaling, Wikipedia:Cannabinoid]


id: GO:0038172
name: interleukin-33-mediated signaling pathway
namespace: biological_process
def:
  "A series of molecular signals initiated by the binding of interleukin-33 to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:jc, GOC:signaling, PR:000001389]


id: GO:0038173
name: interleukin-17A-mediated signaling pathway
namespace: biological_process
def:
  "A series of molecular signals initiated by the binding of interleukin-17A to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:jc, GOC:signaling, PR:000001138]


id: GO:0038174
name: interleukin-17A receptor activity
namespace: molecular_function
def:
  "Combining with the cytokine interleukin-17A and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:bf, GOC:jc, GOC:signaling, PR:000001138]


id: GO:0038175
name: negative regulation of SREBP signaling pathway in response to increased oxygen levels
namespace: biological_process
def:
  "Any process that stops, prevents or reduces the frequency, rate or extent of the SREBP signaling pathway in response to an increase in oxygen levels." [GOC:al, PMID:22017871]


id: GO:0038176
name: positive regulation of SREBP signaling pathway in response to decreased oxygen levels
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of the SREBP signaling pathway in response to a decrease in oxygen levels." [GOC:al, PMID:22017871]


id: GO:0038177
name: death receptor agonist activity
namespace: molecular_function
def:
  "Interacting with a death receptor such that the proportion of death receptors in an active form is increased. Ligand binding to a death receptor often induces a conformational change to activate the receptor." [GOC:mtg_apoptosis, GOC:pr]


id: GO:0038178
name: complement component C5a signaling pathway
namespace: biological_process
def:
  "A series of molecular signals generated as a consequence of a the C5a component of the complement pathway binding to a complement receptor, and ending with regulation of a downstream cellular process. C5a is a peptide derived from the C5 complement factor." [GOC:jc, PMID:15313431, Wikipedia:Complement_component_5a]


id: GO:0038179
name: neurotrophin signaling pathway
namespace: biological_process
def:
  "A series of molecular signals initiated by the binding of a neurotrophin to a receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription. Neurotrophins are a family of secreted growth factors that induce the survival, development, and function of neurons." [GOC:bf, GOC:jc, GOC:signaling, PMID:17466268, PR:000021998, Wikipedia:Neurotrophin]


id: GO:0038180
name: nerve growth factor signaling pathway
namespace: biological_process
def:
  "A series of molecular signals initiated by the binding of nerve growth factor (NGF) to a receptor on the surface of the target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, PMID:11520933, PR:000011194, Wikipedia:Nerve_growth_factor]


id: GO:0038181
name: bile acid receptor activity
namespace: molecular_function
def:
  "Combining with a bile acid and transmitting the signal to initiate a change in cell activity. A bile acid is any member of a group of steroid carboxylic acids occurring in bile." [CHEBI:3098, GOC:bf, PMID:10334992, PMID:12718893]


id: GO:0038182
name: G-protein coupled bile acid receptor activity
namespace: molecular_function
def:
  "Combining with an extracellular bile acid and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, PMID:12524422, Wikipedia:G_protein-coupled_bile_acid_receptor]


id: GO:0038183
name: bile acid signaling pathway
namespace: biological_process
def:
  "A series of molecular signals initiated by the binding of a bile acid to a receptor, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:signaling, PMID:12016314]


id: GO:0038184
name: cell surface bile acid receptor signaling pathway
namespace: biological_process
def:
  "A series of molecular signals initiated by binding of a bile acid to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, PMID:12419312, PMID:19442546]


id: GO:0038185
name: intracellular bile acid receptor signaling pathway
namespace: biological_process
def:
  "A series of molecular signals initiated by a bile acid binding to an receptor located within a cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, PMID:10334992]


id: GO:0038186
name: lithocholic acid receptor activity
namespace: molecular_function
def:
  "Combining with lithocholic acid and transmitting the signal to initiate a change in cell activity." [CHEBI:16325, GOC:bf, PMID:12016314, PMID:12419312]


id: GO:0038187
name: pattern recognition receptor activity
namespace: molecular_function
def:
  "Combining with a pathogen-associated molecular pattern (PAMP), a structure conserved among microbial species, or damage-associated molecular pattern (DAMP), an endogenous molecule released from damaged cells), to initiate a change in cell activity." [GOC:ar, GOC:bf, Wikipedia:Pattern_recognition_receptor]


id: GO:0038188
name: cholecystokinin signaling pathway
namespace: biological_process
def:
  "The series of molecular signals generated as a consequence of cholecystokinin binding to a receptor on the surface of the cell, and proceeding with the activated receptor transmitting the signal to a heterotrimeric G-protein complex to initiate a change in cell activity. Ends with regulation of a downstream cellular process, e.g. transcription." [GOC:jc, PMID:11181948]


id: GO:0038189
name: neuropilin signaling pathway
namespace: biological_process
def:
  "A series of molecular signals initiated by the binding of an extracellular ligand to an neuropilin protein on the surface of a target cell, followed by transmission of the signal, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:BHF, PMID:12852851]


id: GO:0038190
name: VEGF-activated neuropilin signaling pathway
namespace: biological_process
def:
  "A series of molecular signals initiated by the binding of vascular endothelial growth factor (VEGF) to a neuropilin protein on the surface of a target cell, followed by transmission of the signal, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:BHF, GOC:rl, PMID:12852851]


id: GO:0038191
name: neuropilin binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with a member of the neuropilin family." [GOC:bf, PMID:23871893]


id: GO:0038192
name: gastric inhibitory peptide signaling pathway
namespace: biological_process
def:
  "The series of molecular signals generated as a consequence of a gastric inhibitory peptide (GIP) binding to a cell surface receptor. The pathway proceeds with the receptor transmitting the signal to a heterotrimeric G-protein complex and ends with regulation of a downstream cellular process, e.g. transcription." [GOC:nhn, PMID:15955806]


id: GO:0038193
name: thromboxane A2 signaling pathway
namespace: biological_process
def:
  "The series of molecular signals generated as a consequence of thromboxane A2 binding to a cell surface receptor. The pathway proceeds with the receptor transmitting the signal to a heterotrimeric G-protein complex and ends with regulation of a downstream cellular process, e.g. transcription." [GOC:nhn, PMID:15893915]


id: GO:0038194
name: thyroid-stimulating hormone signaling pathway
namespace: biological_process
def:
  "The series of molecular signals generated as a consequence of thyroid-stimulating hormone (thyrotropin) binding to a cell surface receptor. The pathway proceeds with the receptor transmitting the signal to a heterotrimeric G-protein complex and ends with regulation of a downstream cellular process, e.g. transcription." [GOC:gap, PMID:10809230]


id: GO:0038195
name: urokinase plasminogen activator signaling pathway
namespace: biological_process
def:
  "A series of molecular signals initiated by the binding of urokinase plasminogen activator to a receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:gap, PMID:9417082]


id: GO:0038196
name: type III interferon signaling pathway
namespace: biological_process
def:
  "A series of molecular signals initiated by the binding of a type III interferon to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription. Interferon lambda is the only member of the type III interferon found so far." [GOC:pg, GOC:signaling]


id: GO:0038197
name: type I interferon receptor complex
namespace: cellular_component
def:
  "A heterodimeric protein complex that binds a type I interferon and transmits the signal across the membrane into the cell. Consists of an alpha subunit (IFNAR1) and a beta subunit (IFNAR2)." [GOC:cjm, GOC:signaling, PMID:17502368]


id: GO:0038198
name: auxin receptor activity
namespace: molecular_function
def:
  "Combining with auxin and transmitting the signal in the cell to initiate a change in cell activity. Auxin is a plant hormone (phytohormone)." [GOC:signaling, PMID:15917797]


id: GO:0038199
name: ethylene receptor activity
namespace: molecular_function
def:
  "Combining with ethylene and transmitting the signal in the cell to initiate a change in cell activity." [GOC:signaling, PMID:22467798, PMID:24012247]


id: GO:0038200
name: ethylene receptor histidine kinase activity
namespace: molecular_function
def:
  "Combining with ethylene and transmitting the signal within the cell to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-histidine = ADP + a protein-L-histidine phosphate." [GOC:signaling, PMID:22467798]


id: GO:0038201
name: TOR complex
namespace: cellular_component
def:
  "A protein complex that contains at least TOR (target of rapamycin) in complex with other signaling components. Mediates the phosphorylation and activation of downstream signaling components including PKB (AKT) or S6K." [Wikipedia:MTORC1, Wikipedia:MTORC2]


id: GO:0038202
name: TORC1 signaling
namespace: biological_process
def:
  "A series of intracellular molecular signals mediated by TORC1; TOR (target of rapamycin) in complex with at least Raptor (regulatory-associated protein of TOR), or orthologs of, and other signaling components." [GOC:lb]


id: GO:0038203
name: TORC2 signaling
namespace: biological_process
def:
  "A series of intracellular molecular signals mediated by TORC2; TOR (rapamycin-insensitive companion of TOR) in complex with at least Rictor (regulatory-associated protein of TOR), or orthologs of, and other signaling components." [GOC:lb]


id: GO:0039003
name: pronephric field specification
namespace: biological_process
def:
  "The process in which regions of the embryo are delineated into the area in which the pronephric kidney will develop." [GOC:mtg_kidney_jan10]


id: GO:0039004
name: specification of pronephric proximal tubule identity
namespace: biological_process
def:
  "The process in which the proximal tubule of the pronephric nephron acquires its identity." [GOC:mtg_kidney_jan10]


id: GO:0039005
name: specification of pronephric tubule identity
namespace: biological_process
def:
  "The process in which the tubules arranged along the proximal/distal axis of the pronephric nephron acquire their identity." [GOC:mtg_kidney_jan10]


id: GO:0039006
name: pronephric nephron tubule formation
namespace: biological_process
def:
  "The developmental process pertaining to the initial formation of a pronephric nephron tubule from unspecified parts. A pronephric nephron tubule is an epithelial tube that is part of a nephron in the pronephros." [GOC:mtg_kidney_jan10]


id: GO:0039007
name: pronephric nephron morphogenesis
namespace: biological_process
def:
  "The process in which the anatomical structures of the pronephric nephron are generated and organized. A pronephric nephron is the functional unit of the pronephros." [GOC:mtg_kidney_jan10]


id: GO:0039008
name: pronephric nephron tubule morphogenesis
namespace: biological_process
def:
  "The process in which the anatomical structures of a pronephric nephron tubule are generated and organized from an epithelium. A pronephric nephron tubule is an epithelial tube that is part of the pronephric nephron." [GOC:mtg_kidney_jan10, ZFA:00001558]


id: GO:0039009
name: rectal diverticulum development
namespace: biological_process
def:
  "The process whose specific outcome is the progression of the rectal diverticulum over time, from its formation to the mature structure. The rectal diverticulum is an outgrowth of the cloaca and links the pronephric kidney to the exterior." [GOC:mtg_kidney_jan10, PMID:10535314, PMID:18226983, XAO:0001015]


id: GO:0039010
name: specification of pronephric distal tubule identity
namespace: biological_process
def:
  "The process in which the distal tubule of the pronephric nephron acquires its identity." [GOC:mtg_kidney_jan10]


id: GO:0039011
name: pronephric proximal tubule morphogenesis
namespace: biological_process
def:
  "The process in which the anatomical structures of a pronephric nephron proximal tubule are generated and organized. A pronephric nephron tubule is an epithelial tube that is part of the pronephros." [GOC:mtg_kidney_jan10]


id: GO:0039012
name: pronephric sinus development
namespace: biological_process
def:
  "The process whose specific outcome is the progression of the pronephric sinus over time, from its formation to the mature structure. The pronephric sinus is an ill-defined capillary network that lies between the pronephric tubules." [GOC:mtg_kidney_jan10, PMID:10535314, XAO:0000385]


id: GO:0039013
name: pronephric distal tubule morphogenesis
namespace: biological_process
def:
  "The process in which the anatomical structures of a pronephric nephron distal tubule are generated and organized. A pronephric nephron tubule is an epithelial tube that is part of the pronephros." [GOC:mtg_kidney_jan10]


id: GO:0039014
name: cell differentiation involved in pronephros development
namespace: biological_process
def:
  "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells of the pronephros as it progresses from its formation to the mature state." [GOC:mtg_kidney_jan10]


id: GO:0039015
name: cell proliferation involved in pronephros development
namespace: biological_process
def:
  "The multiplication or reproduction of cells, resulting in the expansion of the population in the pronephros." [GOC:mtg_kidney_jan10]


id: GO:0039016
name: cell-cell signaling involved in pronephros development
namespace: biological_process
def:
  "Any process that mediates the transfer of information from one cell to another and contributes to the progression of the pronephros over time, from its formation to the mature organ." [GOC:mtg_kidney_jan10]


id: GO:0039017
name: pattern specification involved in pronephros development
namespace: biological_process
def:
  "Any developmental process that results in the creation of defined areas or spaces within the pronephros to which cells respond and eventually are instructed to differentiate." [GOC:mtg_kidney_jan10]


id: GO:0039018
name: nephrostome development
namespace: biological_process
def:
  "The process whose specific outcome is the progression of the nephrostome over time, from its formation to the mature structure. The nephrostome is the opening of the pronephros into the body cavity." [GOC:mtg_kidney_jan10, PMID:14686690, PMID:15647339, XAO:0000062]


id: GO:0039019
name: pronephric nephron development
namespace: biological_process
def:
  "The process whose specific outcome is the progression of the pronephric nephron over time, from its formation to the mature structure. A pronephric nephron is the functional unit of the pronephros." [GOC:mtg_kidney_jan10, XAO:00002785]


id: GO:0039020
name: pronephric nephron tubule development
namespace: biological_process
def:
  "The process whose specific outcome is the progression of a pronephric nephron tubule over time, from its formation to the mature structure. The pronephric nephron tubule is an epithelial tube that is part of the pronephric nephron and connects the filtration unit (glomerulus or glomus) of the pronephros to the pronephric duct." [GOC:mtg_kidney_jan10, PMID:19909807, PMID:9268568]


id: GO:0039021
name: pronephric glomerulus development
namespace: biological_process
def:
  "The progression of the glomerulus of the pronephric kidney over time from its initial formation until its mature state. The pronephric glomerulus is part of the pronephric nephron and is restricted to one body segment." [GOC:dgh, GOC:mtg_kidney_jan10, ZFA:00001557]


id: GO:0039022
name: pronephric duct development
namespace: biological_process
def:
  "The process whose specific outcome is the progression of the pronephric duct over time, from its formation to the mature structure. The pronephric duct collects the filtrate from the pronephric tubules and opens to the exterior of the pronephric kidney." [GOC:mtg_kidney_jan10, PMID:15647339, XAO:0000063, ZFA:0000150]


id: GO:0039023
name: pronephric duct morphogenesis
namespace: biological_process
def:
  "The process in which the anatomical structures of the pronephric duct are generated and organized. The pronephric duct collects the filtrate from the pronephric tubules and opens to the exterior of the kidney." [GOC:mtg_kidney_jan10, XAO:0000063, ZFA:0000150]


id: GO:0039501
name: suppression by virus of host type I interferon production
namespace: biological_process
def:
  "Any viral process that results in the inhibition of host cell type I interferon production. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families." [GOC:add, GOC:bf, GOC:sp, UniProtKB-KW:KW-1113, VZ:875]


id: GO:0039502
name: suppression by virus of host type I interferon-mediated signaling pathway
namespace: biological_process
def:
  "Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of type I interferon-mediated signaling in the host organism. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families." [GOC:add, GOC:bf, GOC:sp, UniProtKB-KW:KW-1114, VZ:883]


id: GO:0039503
name: suppression by virus of host innate immune response
namespace: biological_process
def:
  "Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of the innate immune response of the host organism, the host's first line of defense." [GOC:add, GOC:bf, GOC:sp, UniProtKB-KW:KW-1090]


id: GO:0039504
name: suppression by virus of host adaptive immune response
namespace: biological_process
def:
  "Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of the adaptive immune response of the host organism, an immune response based on directed amplification of specific receptors for antigen produced through a somatic diversification process, and allowing for enhanced response to subsequent exposures to the same antigen (immunological memory)." [GOC:add, GOC:bf, GOC:sp, UniProtKB-KW:KW-1080]


id: GO:0039505
namespace: biological_process
name:
  suppression by virus of host antigen processing and presentation of peptide antigen via MHC class II

def:
  "Any viral process that inhibits a host antigen-presenting cell expressing a peptide antigen on its cell surface in association with an MHC class II protein complex." [GOC:add, GOC:bf, UniProtKB-KW:KW-1116, VZ:820]


id: GO:0039506
name: modulation by virus of host molecular function
namespace: biological_process
def:
  "The process in which a virus effects a change in the function of a host protein via a direct interaction." [GOC:bf, GOC:sp]


id: GO:0039507
name: suppression by virus of host molecular function
namespace: biological_process
def:
  "Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of the functional activity of a host protein." [GOC:bf, GOC:sp]


id: GO:0039508
name: suppression by virus of host receptor activity
namespace: biological_process
def:
  "Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of the functional activity of a host receptor." [GOC:bf, GOC:sp]


id: GO:0039509
name: suppression by virus of host pattern recognition receptor activity
namespace: biological_process
def:
  "Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of the functional activity of a host pattern recognition receptor. A pattern recognition receptor combines with a molecular pattern based on a repeating or polymeric structure, such as a polysaccharide or peptidoglycan, to initiate a change in cell activity." [GOC:bf, GOC:sp]


id: GO:0039510
name: suppression by virus of host ATP-dependent RNA helicase activity
namespace: biological_process
def:
  "Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host ATP-dependent RNA helicase activity." [GOC:bf, GOC:sp]


id: GO:0039511
name: suppression by virus of host interferon receptor activity
namespace: biological_process
def:
  "Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of the functional activity of a host interferon receptor." [GOC:bf, GOC:sp, UniProtKB-KW:KW-1091, VZ:843]


id: GO:0039512
name: suppression by virus of host protein tyrosine kinase activity
namespace: biological_process
def:
  "Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host protein tyrosine kinase activity." [GOC:bf, GOC:sp]


id: GO:0039513
name: suppression by virus of host catalytic activity
namespace: biological_process
def:
  "Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host enzyme activity." [GOC:bf]


id: GO:0039514
name: suppression by virus of host JAK-STAT cascade
namespace: biological_process
def:
  "Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of the JAK-STAT signal cascade in the host organism." [GOC:bf, GOC:sp]


id: GO:0039517
name: modulation by virus of host protein serine/threonine phosphatase activity
namespace: biological_process
def:
  "The process in which a virus effects a change in host protein serine/threonine phosphatase activity." [GOC:bf, GOC:sp]


id: GO:0039518
name: suppression by virus of host cytokine activity
namespace: biological_process
def:
  "Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host cytokine activity." [GOC:bf, GOC:sp]


id: GO:0039519
name: modulation by virus of host autophagy
namespace: biological_process
def:
  "Any process in which a virus effect a change in the frequency, rate or extent of autophagy in the host." [GOC:bf, GOC:sp]


id: GO:0039520
name: induction by virus of host autophagy
namespace: biological_process
def:
  "Any process in which a virus activates or increases the frequency, rate or extent of autophagy in the host." [GOC:bf, GOC:sp, UniProtKB-KW:KW-1072, VZ:846]


id: GO:0039521
name: suppression by virus of host autophagy
namespace: biological_process
def:
  "Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of autophagy in the host." [GOC:bf, GOC:sp, UniProtKB-KW:KW-1083, VZ:845]


id: GO:0039522
name: suppression by virus of host mRNA export from nucleus
namespace: biological_process
def:
  "Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of movement of mRNA from the nucleus to the cytoplasm in the host organism." [GOC:bf, GOC:sp, UniProtKB-KW:KW-1099, VZ:902]


id: GO:0039523
name: suppression by virus of host RNA polymerase II activity
namespace: biological_process
def:
  "Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host RNA polymerase II activity." [GOC:bf, GOC:sp, UniProtKB-KW:KW-1104, VZ:905]


id: GO:0039524
name: suppression by virus of host mRNA processing
namespace: biological_process
def:
  "Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of mRNA processing in the host cell. mRNA processing is the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide." [GOC:bf, GOC:sp, UniProtKB-KW:KW-1103, VZ:903]


id: GO:0039525
name: modulation by virus of host chromatin organization
namespace: biological_process
def:
  "Any process in which a virus effects a change in the organization of chromatin in the host." [GOC:bf, GOC:sp, UniProtKB-KW:KW-1122]


id: GO:0039526
name: modulation by virus of host apoptotic process
namespace: biological_process
def:
  "Any process in which a virus modulates the frequency, rate or extent of apoptosis of infected host cells." [GOC:bf, GOC:mtg_apoptosis, GOC:sp, UniProtKB-KW:KW-1119]


id: GO:0039527
name: suppression by virus of host TRAF-mediated signal transduction
namespace: biological_process
def:
  "Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of TRAF-mediated signal transduction in the host." [GOC:bf, GOC:sp]


id: GO:0039528
name: cytoplasmic pattern recognition receptor signaling pathway in response to virus
namespace: biological_process
def:
  "Any series of molecular signals generated as a consequence of a virus or viral RNA binding to a pattern recognition receptor (PRR) located in the cytoplasm. Cytosolic PRRs such as RIG-I (DDX58) and MDA-5 (IFIH1) detect RNA synthesized during active viral replication and trigger a signaling pathway to protect the host against viral infection, for example by inducing the expression of antiviral cytokines." [GOC:bf, PMID:17328678, PMID:18272355, PMID:19531363]


id: GO:0039529
name: RIG-I signaling pathway
namespace: biological_process
def:
  "Any series of molecular signals generated as a consequence of the cytoplasmic pattern recognition receptor (PRR) RIG-1 (also known as DDX58) binding to viral RNA. RIG-I detects RNA synthesized during active viral replication and triggers a signaling pathway to protect the host against viral infection, for example by inducing the expression of antiviral cytokines." [GOC:bf, PMID:17328678, PMID:19620789, PMID:21435580]


id: GO:0039530
name: MDA-5 signaling pathway
namespace: biological_process
def:
  "Any series of molecular signals generated as a consequence of the cytoplasmic pattern recognition receptor (PRR) MDA-5 (also known as IFIH1) binding to viral RNA. MDA-5 detects RNA synthesized during active viral replication and triggers a signaling pathway to protect the host against viral infection, for example by inducing the expression of antiviral cytokines." [GOC:bf, PMID:19620789]


id: GO:0039531
name: regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of the series of molecular signals generated as a consequence of a virus or viral RNA binding to a pattern recognition receptor (PRR) located in the cytoplasm." [GOC:bf, GOC:jl]


id: GO:0039532
name: negative regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of the series of molecular signals generated as a consequence of a virus or viral RNA binding to a pattern recognition receptor (PRR) located in the cytoplasm." [GOC:bf, GOC:jl]


id: GO:0039533
name: regulation of MDA-5 signaling pathway
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of the series of molecular signals generated as a consequence of the cytoplasmic pattern recognition receptor (PRR) MDA-5 (also known as IFIH1) binding to viral RNA." [GOC:bf, GOC:jl]


id: GO:0039534
name: negative regulation of MDA-5 signaling pathway
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of the series of molecular signals generated as a consequence of the cytoplasmic pattern recognition receptor (PRR) MDA-5 (also known as IFIH1) binding to viral RNA." [GOC:bf, GOC:jl]


id: GO:0039535
name: regulation of RIG-I signaling pathway
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of the series of molecular signals generated as a consequence of the cytoplasmic pattern recognition receptor (PRR) RIG-1 (also known as DDX58) binding to viral RNA." [GOC:bf, GOC:jl]


id: GO:0039536
name: negative regulation of RIG-I signaling pathway
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of the series of molecular signals generated as a consequence of the cytoplasmic pattern recognition receptor (PRR) RIG-1 (also known as DDX58) binding to viral RNA." [GOC:bf, GOC:jl]


id: GO:0039537
namespace: biological_process
name:
  suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway

def:
  "Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of the series of molecular signals generated as a consequence of a virus or viral RNA binding to a pattern recognition receptor (PRR) located in the cytoplasm. This is a mechanism by which the virus evades the host innate immune response." [GOC:bf, GOC:jl]


id: GO:0039538
name: suppression by virus of host RIG-I signaling pathway
namespace: biological_process
def:
  "Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of the series of molecular signals generated as a consequence of the cytoplasmic pattern recognition receptor (PRR) RIG-1 (also known as DDX58) binding to viral RNA. This is a mechanism by which the virus evades the host innate immune response." [GOC:bf, GOC:jl]


id: GO:0039539
name: suppression by virus of host MDA-5 signaling pathway
namespace: biological_process
def:
  "Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of the series of molecular signals generated as a consequence of the cytoplasmic pattern recognition receptor (PRR) MDA-5 (also known as IFIH1) binding to viral RNA. This is a mechanism by which the virus evades the host innate immune response." [GOC:bf, GOC:jl]


id: GO:0039540
name: suppression by virus of host RIG-I activity
namespace: biological_process
def:
  "Any process in which a virus stops, prevents, or reduces the activity of RIG-1 (also known as DDX58). The cytoplasmic pattern recognition RIG-I recognizes viral RNA synthesized during active viral replication and signals to protect the host against viral infection, for example by inducing the expression of antiviral cytokines." [GOC:bf, GOC:sp, UniProtKB-KW:KW-1088, VZ:856]


id: GO:0039541
name: suppression by virus of host RIG-I via RIG-I binding
namespace: biological_process
def:
  "Any process in which a virus stops, prevents, or reduces the activity of RIG-I (also known as DDX58) by interacting selectively and non-covalently with RIG-I itself." [PMID:19193793, PMID:20007272, VZ:856]


id: GO:0039542
name: suppression by virus of host RIG-I K63-linked ubiquitination
namespace: biological_process
def:
  "Any process in which a virus stops, prevents, or reduces the rate or extent of K63-linked ubiquitination of RIG-I (also known as DDX58), thereby suppressing RIG-I signal transduction. Lys63-linked ubiquitination of the N-terminal CARD domains of RIG-I is crucial for the cytosolic RIG-I signaling pathway to elicit host antiviral innate immunity." [PMID:19454348, PMID:21890623]


id: GO:0039543
name: suppression by virus of host RIG-I activity by viral RNA 5' processing
namespace: biological_process
def:
  "The post-transcriptional removal by a virus of the 5' triphosphate group of their viral RNA, thereby preventing host RIG-I from recognizing viral RNA in the host cell. The intracellular pattern recognition receptor RIG-I (also known as DDX58) recognizes viral RNAs containing 5' triphosphates; removal by the virus of the 5'-terminal triphosphate group from their genome protects the viral RNA from RIG-recognition." [PMID:18446221, VZ:856]


id: GO:0039544
name: suppression by virus of host RIG-I activity by RIG-I proteolysis
namespace: biological_process
def:
  "The chemical reactions and pathways performed by a virus resulting in the hydrolysis of the host RIG-I protein (also known as DDX58) by cleavage of peptide bonds, thereby inhibiting RIG-I signal transduction." [PMID:19628239]


id: GO:0039545
name: suppression by virus of host MAVS activity
namespace: biological_process
def:
  "Any process in which a virus stops, prevents, or reduces the activity of MAVS (mitochondrial antiviral signaling protein), a signal transducer that lies downstream of the viral RNA receptors MDA-5 and RIG-I to coordinate host innate immune responses." [UniProtKB-KW:KW-1097, VZ:704]


id: GO:0039546
name: suppression by virus of host MAVS activity by MAVS proteolysis
namespace: biological_process
def:
  "The chemical reactions and pathways performed by a virus resulting in the hydrolysis of the host MAVS (mitochondrial inhibitor of viral signaling) protein by cleavage of peptide bonds, thereby inhibiting the host innate immune response. For example, MAVS harbors a C-terminal transmembrane domain that targets it to the mitochondrial outer membrane; cleavage within this domain removes MAVS from the membrane, thus preventing it from signaling." [PMID:21436888, PMID:22238314]


id: GO:0039547
name: suppression by virus of host TRAF activity
namespace: biological_process
def:
  "Any process in which a virus stops, prevents, or reduces the activity of a host TRAF (tumor necrosis factor receptor-associated factor) protein. TRAFs are intracellular signal transducers that lie downstream of receptors including RIG-I, MDA-5 and Toll-like receptors (TLR) and transfer the signal to other intracellular signaling components." [GOC:bf, UniProtKB-KW:KW-1110, VZ:715]


id: GO:0039548
name: suppression by virus of host IRF3 activity
namespace: biological_process
def:
  "Any process in which a virus stops, prevents, or reduces the activity of host IRF3 (interferon regulatory factor-3), a transcription factor in the RIG-I/MDA-5 signaling pathway. Viral infection triggers phosphorylation of cytoplasmic IRF3, which allows IRF3 to form a homodimer, migrate to the nucleus, and activate transcription of IFN-alpha and IFN-beta genes." [PMID:21632562, UniProtKB-KW:KW-1092, VZ:757]


id: GO:0039549
name: suppression by virus of host IRF3 activity by inhibition of IRF3 phosphorylation
namespace: biological_process
def:
  "Any process in which a virus stops, prevents, or reduces the rate or extent of the phosphorylation of IRF3 (interferon regulatory factor-3), thereby inhibiting IRF3 activation. In response to signaling from RIG-1/MDA-5 receptors, IRF3 is phosphorylated on multiple serine and threonine residues; phosphorylation results in the cytoplasm-to-nucleus translocation of IRF3, DNA binding, and increased transcriptional activation of interferon-encoding genes." [PMID:11124948, PMID:12829834, PMID:20631144, PMID:9566918]


id: GO:0039550
name: suppression by virus of host IRF3 activity by inhibition of DNA binding
namespace: biological_process
def:
  "Any process in which a virus stops, prevents, or reduces IRF3-dependent gene transcription, by preventing or reducing IRF3 binding to promoter sites." [PMID:21632562]


id: GO:0039551
name: suppression by virus of host IRF3 activity by positive regulation of IRF3 catabolic process
namespace: biological_process
def:
  "Any process in which a virus stops, prevents, or reduces the activity of host IRF3 (interferon regulatory factor-3) by promoting the ubiquitin-dependent degradation of IRF3, mediated by the proteasome." [VZ:757]


id: GO:0039552
name: RIG-I binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with RIG-I, a cytosolic pattern recognition receptor that initiates an antiviral signaling pathway upon binding to viral RNA." [GOC:bf, PMID:21233210]


id: GO:0039553
name: suppression by virus of host chemokine activity
namespace: biological_process
def:
  "Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host chemokine activity." [GOC:bf, GOC:sp, UniProtKB-KW:KW-1086, VZ:813]


id: GO:0039554
name: suppression by virus of host MDA-5 activity
namespace: biological_process
def:
  "Any process in which a virus stops, prevents, or reduces the activity of MDA-5 (also known as IFIH1). The cytoplasmic pattern recognition receptor MDA-5 detects dsRNA synthesized during active viral replication and triggers a signaling pathway to protect the host against viral infection, for example by inducing the expression of antiviral cytokines." [UniProtKB-KW:KW-1089, VZ:603]


id: GO:0039555
name: suppression by virus of host MDA-5 activity via MDA-5 binding
namespace: biological_process
def:
  "Any process in which a virus stops, prevents, or reduces the activity of MDA-5 (also known as IFIH1) by interacting selectively and non-covalently with MDA-5 itself. For example, direct binding of viral proteins to the host MDA-5 protein can inhibit interaction of MDA-5 with MAVS, its downstream signaling effector." [PMID:19019954, VZ:603]


id: GO:0039556
name: MDA-5 binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with MDA-5, a cytosolic pattern recognition receptor that initiates an antiviral signaling pathway upon binding to viral dsRNA." [PMID:19019954]


id: GO:0039557
name: suppression by virus of host IRF7 activity
namespace: biological_process
def:
  "Any process in which a virus stops, prevents, or reduces the activity of host IRF7 (interferon regulatory factor-7), a transcription factor in the RIG-I/MDA-5 signaling pathway. Viral infection triggers phosphorylation of cytoplasmic IRF7, which allows IRF7 to form a homodimer, migrate to the nucleus, and activate transcription of IFN-alpha and IFN-beta genes." [UniProtKB-KW:KW-1093, VZ:653]


id: GO:0039558
name: suppression by virus of host IRF7 activity by positive regulation of IRF7 sumoylation
namespace: biological_process
def:
  "Any process in which a virus stops, prevents, or reduces IRF7-dependent gene transcription, by promoting the sumoylation of IRF7, thereby disabling its activity." [PMID:18635538, PMID:19694547, VZ:653]


id: GO:0039559
name: suppression by virus of host IRF7 activity by positive regulation of IRF7 catabolic process
namespace: biological_process
def:
  "Any process in which a virus stops, prevents, or reduces the activity of host IRF7 (interferon regulatory factor-7) by promoting the ubiquitin-dependent degradation of IRF7, mediated by the proteasome." [PMID:17301153, VZ:653]


id: GO:0039560
name: suppression by virus of host IRF9 activity
namespace: biological_process
def:
  "Any process in which a virus stops, prevents, or reduces the activity of host IRF9 (interferon regulatory factor-9), a transcription factor involved in the innate immune response. Viral infection triggers binding of IRF9 to phosphorylated STAT1 and STAT2, forming the ISGF3 complex. The ISGF3 complex migrates to the nucleus and activates transcription of IFN-responsive genes." [UniProtKB-KW:KW-1094, VZ:683]


id: GO:0039561
name: suppression by virus of host IRF9 activity by positive regulation of IRF9 localization to nucleus
namespace: biological_process
def:
  "Any process in which a virus stops, prevents, or reduces the activity of host IRF9 (interferon regulatory factor-9) by promoting the nuclear accumulation of IRF9. For example, the reovirus mu2 protein promotes nuclear accumulation of host IRF9 by an as yet unconfirmed-mechanism." [PMID:19109390]


id: GO:0039562
name: suppression by virus of host STAT activity
namespace: biological_process
def:
  "Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host STAT (signal transducer and activator of transcription) activity. STATs are SH2 domain-containing proteins which lie downstream of many signaling receptors. Upon phosphorylation by JAKs, STAT proteins hetero- or homo-dimerize and translocate to the nucleus to activate transcription of target genes." [GOC:bf]


id: GO:0039563
name: suppression by virus of host STAT1 activity
namespace: biological_process
def:
  "Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host STAT1 (signal transducer and activator of transcription-1) activity. STATs are SH2 domain-containing proteins which lie downstream of many signaling receptors. Upon phosphorylation by JAKs, STAT proteins hetero- or homo-dimerize and translocate to the nucleus to activate transcription of target genes." [UniProtKB-KW:KW-1105, VZ:282]


id: GO:0039564
name: suppression by virus of host STAT2 activity
namespace: biological_process
def:
  "Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host STAT2 (signal transducer and activator of transcription-2) activity. STATs are SH2 domain-containing proteins which lie downstream of many signaling receptors. Upon phosphorylation by JAKs, STAT proteins hetero- or homo-dimerize and translocate to the nucleus to activate transcription of target genes." [UniProtKB-KW:KW-1106, VZ:257]


id: GO:0039565
name: suppression by virus of host STAT1 activity by positive regulation of STAT1 catabolic process
namespace: biological_process
def:
  "Any process in which a virus stops, prevents, or reduces the activity of host STAT1 (signal transducer and activator of transcription-1) by promoting the ubiquitin-dependent degradation of STAT1, mediated by the proteasome." [PMID:15280488, PMID:16227264, VZ:282]


id: GO:0039566
name: suppression by virus of host STAT1 activity by tyrosine dephosphorylation of STAT1
namespace: biological_process
def:
  "Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host STAT1 (signal transducer and activator of transcription-1) activity by the removal of phosphoric residues from STAT1-O-phospho-tyrosine to form STAT1-tyrosine. For example, the viral phosphatase VH1 dephosphorylates STAT1 to reverse STAT1 activation." [PMID:11238845, PMID:21362620, VZ:282]


id: GO:0039567
namespace: biological_process
name:
  suppression by virus of host STAT1 activity by negative regulation of STAT protein import into nucleus

def:
  "Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host STAT1 (signal transducer and activator of transcription-1) activity by retaining STAT1 in the cytoplasm, so STAT1 is unable to translocate to the nucleus to activate transcription of its target genes." [PMID:14557668, PMID:16254375, PMID:17287281]


id: GO:0039568
name: suppression by virus of host STAT1 activity by inhibition of DNA binding
namespace: biological_process
def:
  "Any process in which a virus stops, prevents, or reduces STAT1-dependent gene transcription, by preventing STAT1 from binding to promoter sites in the nucleus." [PMID:17287281]


id: GO:0039569
name: suppression by virus of host STAT2 activity by positive regulation of STAT2 catabolic process
namespace: biological_process
def:
  "Any process in which a virus stops, prevents, or reduces the activity of host STAT2 (signal transducer and activator of transcription-2) by promoting the ubiquitin-dependent degradation of STAT2, mediated by the proteasome." [PMID:11336548, PMID:17251292, PMID:19279106, VZ:257]


id: GO:0039570
namespace: biological_process
name:
  suppression by virus of host STAT2 activity by negative regulation of STAT protein import into nucleus

def:
  "Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host STAT2 (signal transducer and activator of transcription-2) activity by retaining STAT2 in the cytoplasm, so STAT2 is unable to translocate to the nucleus to activate transcription of its target genes." [PMID:14557668]


id: GO:0039571
namespace: biological_process
name:
  suppression by virus of host STAT1 activity by negative regulation of STAT1 tyrosine phosphorylation

def:
  "Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host STAT1 (signal transducer and activator of transcription-1) activity by stopping, preventing, or reducing the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a STAT1 protein. For example, the measles virus V protein inhibits tyrosine phosphorylation of STAT1, thereby preventing STAT1 activation." [PMID:12804771]


id: GO:0039572
namespace: biological_process
name:
  suppression by virus of host STAT2 activity by negative regulation of STAT2 tyrosine phosphorylation

def:
  "Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host STAT2 (signal transducer and activator of transcription-2) activity by stopping, preventing, or reducing the frequency, rate or extent of the introduction of a phosphate group to a tyrosine residue of a STAT2 protein. For example, the measles virus V protein inhibits tyrosine phosphorylation of STAT2, thereby preventing STAT2 activation." [PMID:12804771]


id: GO:0039573
name: suppression by virus of host complement activation
namespace: biological_process
def:
  "Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of complement activation. The activation of complement involves the sequential proteolysis of proteins to generate enzymes with catalytic activities. The biological functions of the complement include opsonization, inflammation, lysis of immune complexes, or enhancement of the humoral immune response. For example, the virus complement control protein (VCP) of vaccinia virus, and the complement control protein of herpesvirus inhibit C3 convertase." [PMID:21191012, PMID:7745740, UniProtKB-KW:KW-1087, VZ:811]


id: GO:0039574
name: suppression by virus of host TYK2 activity
namespace: biological_process
def:
  "Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host TYK2 (tyrosine kinase 2) activity. TYK2 is an intracellular signal-transducing tyrosine kinase that associates with the cytoplasmic tails of cytokine receptors and transmits the cytokine signal by phosphorylating receptor subunits." [UniProtKB-KW:KW-1112, VZ:720]


id: GO:0039575
name: suppression by virus of host TYK2 activity by negative regulation of TYK2 tyrosine phosphorylation
namespace: biological_process
def:
  "Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host TYK2 (tyrosine kinase 2) activity by stopping, preventing or reducing phosphorylation and thereby activation of TYK2." [PMID:10523853, PMID:16987978, PMID:19254804]


id: GO:0039576
name: suppression by virus of host JAK1 activity
namespace: biological_process
def:
  "Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host JAK1 (Janus Kinase 1) activity. In the host, binding of a ligand to a receptor triggers activation of JAK proteins, which phosphorylate tyrosine residues on the receptor creating sites for STAT proteins to bind, which are in turn phosphorylated and activated by JAK proteins. By blocking JAK1 activity, many viruses block the host signal transduction pathway." [UniProtKB-KW:KW-1096, VZ:784]


id: GO:0039577
name: suppression by virus of host JAK1 activity by negative regulation of JAK1 phosphorylation
namespace: biological_process
def:
  "Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host JAK1 (Janus Kinase 1) activity by stopping, preventing or reducing tyrosine phosphorylation of JAK1 and thereby activation of JAK1." [PMID:12620806]


id: GO:0039578
name: suppression by virus of host JAK1 activity via JAK1 binding
namespace: biological_process
def:
  "Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host JAK1 (Janus Kinase 1) activity by interacting directly and selectively with JAK1. For example, the polyoma virus T antigen binds to JAK1 and renders it inactive." [PMID:9448289]


id: GO:0039579
name: suppression by virus of host ISG15 activity
namespace: biological_process
def:
  "Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host ubiquitin-like protein ISG15 activity. ISG15 is a ubiquitin-like protein that is conjugated to lysine residues on various target proteins. Viruses escape from the antiviral activity of ISG15 by using different mechanisms; the influenza B virus NS1 protein for instance blocks the covalent linkage of ISG15 to its target proteins by directly interacting with ISG15. The papain-like protease from the coronavirus cleaves ISG15 derivatives." [PMID:11157743, PMID:18604270, UniProtKB-KW:KW-1095, VZ:723]


id: GO:0039580
name: suppression by virus of host PKR activity
namespace: biological_process
def:
  "Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host PKR (protein kinase regulated by RNA) activity. Activation of PKR involves dsRNA binding followed by autophosphorylation. Phosphorylated PKR can then phosphorylate downstream targets such as the translation initiation factor eIF2 to inhibit protein synthesis. Viruses encode a number of mechanisms to inhibit the host antiviral response via PKR, including direct interaction with PKR, promoting degradation of PKR or altering the subcellular location of PKR." [PMID:15207627, UniProtKB-KW:KW-1102, VZ:554]


id: GO:0039581
name: suppression by virus of host PKR activity via double-stranded RNA binding
namespace: biological_process
def:
  "Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host PKR (protein kinase regulated by RNA) activity by interacting selectively and non-covalently with double-stranded RNA (dsRNA). Binding of viral proteins to RNA may sequester or alter the RNA so it can not be recognized by host PKR, or may compete with PKR for dsRNA binding." [PMID:7514679]


id: GO:0039582
name: suppression by virus of host PKR activity by positive regulation of PKR nuclear localization
namespace: biological_process
def:
  "Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host PKR (protein kinase regulated by RNA) activity by promoting the localization of PKR in the nucleus. For example, human cytomegalovirus (HMCV) gene products directly interact with PKR and inhibit its activation by sequestering it in the nucleus, away from both its activator (cytoplasmic dsRNA) and its substrate, (eIF2alpha)." [PMID:16987971]


id: GO:0039583
name: suppression by virus of host PKR activity by positive regulation of PKR catabolic process
namespace: biological_process
def:
  "Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host PKR (protein kinase regulated by RNA) activity by promoting the degradation of PKR via the proteosome. For example, the Rift Valley fever virus (RVFV) NSs protein induces the down-regulation of PKR by degradation through proteasomes." [PMID:19751406]


id: GO:0039584
name: suppression by virus of host protein kinase activity
namespace: biological_process
def:
  "Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host protein kinase activity." [GOC:bf]


id: GO:0039585
name: PKR signal transduction
namespace: biological_process
def:
  "A series of reactions in which a signal is passed on to downstream proteins within the cell via PKR, an intracellular protein kinase that is activated by stress signals or upon binding to double-stranded RNA (dsRNA), followed by autophosphorylation. PKR plays a role in the antiviral response, phosphorylating proteins such as the translation initiation factor eIF2 to inhibit protein synthesis during viral infection. Begins with activation of PKR activity, and ends with regulation of a downstream cellular process, e.g. regulation of transcription or inhibition of translation." [PMID:21204021, PMID:22102852, PMID:9843495, VZ:1576]


id: GO:0039586
name: modulation by virus of host PP1 activity
namespace: biological_process
def:
  "The process in which a virus effects a change in host protein phosphatase-1 (PP1) activity, a serine/threonine phosphatase. Different viruses modulate host PP1 activity to remove phosphates from various cellular substrates and downregulate the host's antiviral response." [UniProtKB-KW:KW-1126, VZ:803]


id: GO:0039587
name: suppression by virus of host tetherin activity
namespace: biological_process
def:
  "Any process in which a virus stops, prevents, or reduces the activity of host tetherin activity. Tetherin (also known as BST2) is an alpha interferon-inducible cellular factor that impairs the release of many enveloped viruses. By blocking tetherin activity, many viruses circumvent its antiviral effects." [PMID:22493439, UniProtKB-KW:KW-1084, VZ:665]


id: GO:0039588
name: suppression by virus of host antigen processing and presentation
namespace: biological_process
def:
  "Any viral process that inhibits a host antigen-presenting cell expressing a peptide antigen on its cell surface in association with an MHC protein complex." [UniProtKB-KW:KW-1117, VZ:815]


id: GO:0039589
name: suppression by virus of host TAP complex
namespace: biological_process
def:
  "Any process in which a virus stops, prevents, or reduces the activity of the host TAP complex, a heterodimer composed of the subunits TAP1 and TAP2 (transporter associated with antigen presentation). The TAP complex functions in the transport of antigenic peptides from the cytosol to the lumen of the endoplasmic reticulum, where they are loaded onto the MHC class I. By inhibiting the TAP complex, the virus prevents viral particles being presented at the cell surface, and thus evades the host immune response." [PMID:16691491, UniProtKB-KW:KW-1107, VZ:817]


id: GO:0039591
name: suppression by virus of host tapasin activity
namespace: biological_process
def:
  "Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host tapasin (TAP binding protein/TAPBP) activity. Tapasin is a type I transmembrane protein essential for the optimal expression of stable MHC class I molecules on the host cell surface. By inhibiting host tapasin activity, viruses can prevent presentation of their antigens at the cell surface, and thereby evade the host anti-viral immune response." [UniProtKB-KW:KW-1108, VZ:818]


id: GO:0039592
name: suppression by virus of G2/M transition of host mitotic cell cycle
namespace: biological_process
def:
  "Any viral process that decreases the rate or extent of progression from G2 phase to M phase of the host mitotic cell cycle." [UniProtKB-KW:KW-1079, VZ:876]


id: GO:0039593
name: suppression by virus of host exit from mitosis
namespace: biological_process
def:
  "Any viral process which decreases the rate or extent of a host cell leaving M phase of the cell cycle. M phase is the part of the mitotic cell cycle during which mitosis and cytokinesis take place." [UniProtKB-KW:KW-1098, VZ:877]


id: GO:0039594
name: endoribonuclease activity involved in viral induction of host mRNA catabolic process
namespace: molecular_function
def:
  "Any endoribonuclease activity that contributes to the viral-induced catabolism of host mRNA." [GOC:bf, PMID:22046136]


id: GO:0039595
name: induction by virus of catabolism of host mRNA
namespace: biological_process
def:
  "The process in which a virus increases the frequency, rate or extent of the breakdown of host messenger RNA (mRNA)." [GOC:bf, UniProtKB-KW:KW-1132]


id: GO:0039596
name: modulation by virus of host protein dephosphorylation
namespace: biological_process
def:
  "Any viral process that modulates the frequency, rate or extent of dephosphorylation of a host protein." [GOC:bf]


id: GO:0039597
name: induction by virus of host endoribonuclease activity
namespace: biological_process
def:
  "Any viral process that activates or increases the frequency, rate or extent of host endoribonuclease activity." [PMID:22174690]


id: GO:0039598
name: obsolete induction by virus of host nuclear polyadenylation-dependent mRNA catabolic process
namespace: biological_process
def:
  "OBSOLETE. The process in which a virus increases the frequency, rate or extent of the breakdown of host messenger RNA (mRNA) initiated by the enzymatic addition of a sequence of adenylyl residues (polyadenylation) at the 3' end the target mRNA." [GOC:sp]


id: GO:0039599
name: cleavage by virus of host mRNA
namespace: biological_process
def:
  "Any process in which a host pre-mRNA or mRNA molecule is cleaved at specific sites or in a regulated manner by a viral endoribonuclease." [PMID:22046136]


id: GO:0039600
name: induction by virus of host endonucleolytic cleavage-dependent mRNA catabolic process
namespace: biological_process
def:
  "The process in which a virus increases the frequency, rate or extent of the breakdown of host nuclear-transcribed mRNAs that begins with endonucleolytic cleavage (by either a host or a viral RNAse) to generate unprotected ends." [GOC:bf, PMID:22174690]


id: GO:0039602
name: suppression by virus of host transcription initiation from RNA polymerase II promoter
namespace: biological_process
def:
  "Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of the assembly of the RNA polymerase II preinitiation complex (PIC) at an RNA polymerase II promoter region of a host DNA template." [UniProtKB-KW:KW-1111, VZ:904]


id: GO:0039603
namespace: molecular_function
name:
  TBP-class protein binding involved in viral suppression of host transcription initiation from RNA polymerase II promoter

def:
  "Selective and non-covalent interaction of a viral protein with a member of the class of TATA-binding proteins (TBP) in the host, including any of the TBP-related factors (TRFs), which contributes to the viral-suppression of assembly of the RNA polymerase II preinitiation complex (PIC) at an RNA polymerase II promoter region of a host DNA template." [GOC:vw, PMID:11968006]


id: GO:0039604
name: suppression by virus of host translation
namespace: biological_process
def:
  "Any process in which a virus prevents or reduces the frequency, rate or extent of translation of host mRNA." [UniProtKB-KW:KW-1193, VZ:1579]


id: GO:0039605
namespace: molecular_function
name:
  TFIIB-class transcription factor binding involved in viral suppression of host transcription initiation from RNA polymerase II promoter

def:
  "Selective and non-covalent interaction of a viral protein with a member of the TFIIB-class of host transcription factors, which contributes to the viral-suppression of assembly of the RNA polymerase II preinitiation complex (PIC) at an RNA polymerase II promoter region of a host DNA template." [GOC:vw, PMID:18768974]


id: GO:0039606
name: suppression by virus of host translation initiation
namespace: biological_process
def:
  "Any process in which a virus prevents or reduces the frequency, rate or extent of host translation initiation, the host process preceding formation of the peptide bond between the first two amino acids of a protein." [GOC:bf]


id: GO:0039607
name: proteolysis by virus of host translation initiation factor
namespace: biological_process
def:
  "The chemical reactions and pathways performed by a virus resulting in the hydrolysis of a host translation initiation factor by cleavage of its peptide bonds." [PMID:18572216]


id: GO:0039608
namespace: biological_process
name:
  suppression by virus of host translation initiation factor activity by induction of host protein dephosphorylation

def:
  "Any process in which a virus prevents or reduces the frequency, rate or extent of activity of a host translation initiation factor by promoting dephosphorylation of a host protein." [PMID:12239292, PMID:8643618]


id: GO:0039611
name: suppression by virus of host translation initiation factor activity
namespace: biological_process
def:
  "Any process in which a virus prevents or reduces the frequency, rate or extent of activity of a host translation initiation factor." [GOC:bf, UniProtKB-KW:KW-1075]


id: GO:0039612
name: modulation by virus of host protein phosphorylation
namespace: biological_process
def:
  "Any viral process that modulates the frequency, rate or extent of phosphorylation of viral or host proteins in a host." [GOC:bf]


id: GO:0039613
name: suppression by virus of host protein phosphorylation
namespace: biological_process
def:
  "Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of phosphorylation of viral or host proteins in a host." [GOC:bf]


id: GO:0039614
name: induction by virus of host protein phosphorylation
namespace: biological_process
def:
  "Any process in which a virus activates or increases the frequency, rate or extent of phosphorylation of viral or host proteins in a host." [GOC:bf]


id: GO:0039615
name: T=1 icosahedral viral capsid
namespace: cellular_component
def:
  "The protein coat that surrounds the infective nucleic acid in some virus particles where the subunits (capsomeres) are arranged to form an icosahedron with T=1 symmetry. The T=1 capsid is composed of 12 pentameric capsomeres." [UniProtKB-KW:KW-1140, VZ:1057]


id: GO:0039616
name: T=2 icosahedral viral capsid
namespace: cellular_component
def:
  "The protein coat that surrounds the infective nucleic acid in some virus particles where the subunits (capsomeres) are arranged to form an icosahedron with T=2 symmetry. The T=2 capsid is composed of 12 pentameric dimers." [UniProtKB-KW:KW-1141, VZ:838]


id: GO:0039617
name: T=3 icosahedral viral capsid
namespace: cellular_component
def:
  "The protein coat that surrounds the infective nucleic acid in some virus particles where the subunits (capsomeres) are arranged to form an icosahedron with T=3 symmetry. The T=3 capsid is composed of 12 pentameric and 20 hexameric capsomeres." [UniProtKB-KW:KW-1142, VZ:806]


id: GO:0039618
name: T=pseudo3 icosahedral viral capsid
namespace: cellular_component
def:
  "The protein coat that surrounds the infective nucleic acid in some virus particles where the subunits (capsomeres) are arranged to form an icosahedron with pseudo T=3 symmetry. The T=pseudo3 capsid is composed of 12 pentameric and 20 hexameric capsomeres." [UniProtKB-KW:KW-1143, VZ:809]


id: GO:0039619
name: T=4 icosahedral viral capsid
namespace: cellular_component
def:
  "The protein coat that surrounds the infective nucleic acid in some virus particles where the subunits (capsomeres) are arranged to form an icosahedron with T=4 symmetry. The T=4 capsid is composed of 12 pentameric and 30 hexameric capsomeres." [UniProtKB-KW:KW-1144, VZ:808]


id: GO:0039620
name: T=7 icosahedral viral capsid
namespace: cellular_component
def:
  "The protein coat that surrounds the infective nucleic acid in some virus particles where the subunits (capsomeres) are arranged to form an icosahedron with T=7 symmetry. The T=7 capsid is composed of 12 pentameric and 60 hexameric capsomeres." [UniProtKB-KW:KW-1145, VZ:804]


id: GO:0039621
name: T=13 icosahedral viral capsid
namespace: cellular_component
def:
  "The protein coat that surrounds the infective nucleic acid in some virus particles where the subunits (capsomeres) are arranged to form an icosahedron with T=13 symmetry. The T=13 capsid is composed of 12 pentameric and 120 hexameric capsomeres." [UniProtKB-KW:KW-1146, VZ:260]


id: GO:0039622
name: T=16 icosahedral viral capsid
namespace: cellular_component
def:
  "The protein coat that surrounds the infective nucleic acid in some virus particles where the subunits (capsomeres) are arranged to form an icosahedron with T=16 symmetry. The T=16 capsid is composed of 12 pentameric and 150 hexameric capsomeres." [UniProtKB-KW:KW-1147, VZ:807]


id: GO:0039623
name: T=25 icosahedral viral capsid
namespace: cellular_component
def:
  "The protein coat that surrounds the infective nucleic acid in some virus particles where the subunits (capsomeres) are arranged to form an icosahedron with T=25 symmetry. The T=25 capsid is composed of 12 pentameric and 240 hexameric capsomeres." [UniProtKB-KW:KW-1148, VZ:810]


id: GO:0039624
name: viral outer capsid
namespace: cellular_component
def:
  "The outer layer of a double or triple concentric icosahedral capsid. Outer capsids are part of reoviridae and cystoviridae virions." [UniProtKB-KW:KW-1152]


id: GO:0039625
name: viral inner capsid
namespace: cellular_component
def:
  "The inner layer of a double or triple concentric icosahedral capsid. Inner capsids are part of reoviridae and cystoviridae virions." [UniProtKB-KW:KW-1153]


id: GO:0039626
name: viral intermediate capsid
namespace: cellular_component
def:
  "The intermediate layer of a triple concentric icosahedral capsid. Intermediate capsids are part of reoviridae virions." [UniProtKB-KW:KW-1154]


id: GO:0039627
name: T=147 icosahedral capsid
namespace: cellular_component
def:
  "The protein coat that surrounds the infective nucleic acid in some virus particles where the subunits (capsomeres) are arranged to form an icosahedron with T=147 symmetry. T=147 icosahedral capsid is composed of 12 pentameric and 1460 hexameric capsomeres for a total of 8820 capsid proteins." [GOC:plm, UniProtKB-KW:KW-0167]


id: GO:0039628
name: T=169 icosahedral viral capsid
namespace: cellular_component
def:
  "The protein coat that surrounds the infective nucleic acid in some virus particles where the subunits (capsomeres) are arranged to form an icosahedron with T=169 symmetry. T=169 icosahedral capsid is composed of 12 pentameric and 1680 hexameric capsomeres for a total of 10140 capsid proteins." [GOC:plm, UniProtKB-KW:KW-1150]


id: GO:0039629
name: T=219 icosahedral capsid
namespace: cellular_component
def:
  "The protein coat that surrounds the infective nucleic acid in some virus particles where the subunits (capsomeres) are arranged to form an icosahedron with T=219 symmetry. T=219 icosahedral capsid is composed of 12 pentameric and 2180 hexameric capsomeres for a total of 13140 capsid proteins." [GOC:plm, UniProtKB-KW:KW-1151]


id: GO:0039630
name: RNA translocase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive movement along a single- or double-stranded RNA molecule." [GOC:bm, PMID:22713318]


id: GO:0039631
name: DNA translocase activity involved in viral DNA genome packaging
namespace: molecular_function
def:
  "Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive movement along a single- or double-stranded DNA molecule, that contributes to the packing of viral DNA into a capsid." [GOC:bm, PMID:17501915]


id: GO:0039632
name: RNA translocase activity involved in viral RNA genome packaging
namespace: molecular_function
def:
  "Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive movement along a single- or double-stranded RNA molecule, which contributes to the packaging of viral RNA into a nucleocapsid." [GOC:bm, PMID:22297533]


id: GO:0039633
name: killing by virus of host cell
namespace: biological_process
def:
  "Any process mediated by a virus that results in the death of a cell in the host organism." [GOC:bf, GOC:bm, GOC:jl]


id: GO:0039634
name: killing by virus of host cell during superinfection exclusion
namespace: biological_process
def:
  "The viral-killing of a host cell by a pre-existing virus in response to a subsequent infection of the host cell by second virus." [GOC:bf, GOC:bm, GOC:jl, PMID:22398285]


id: GO:0039635
name: suppression by virus of host peptidoglycan biosynthetic process
namespace: biological_process
def:
  "Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of peptidoglycan biosynthesis in the host organism. Peptidoglycans are any of a class of glycoconjugates found in bacterial cell walls." [GOC:bf, GOC:bm, GOC:jl]


id: GO:0039636
name: suppression by virus of host cell wall biogenesis
namespace: biological_process
def:
  "Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of cell wall biogenesis in the host organism. Cell wall biogenesis includes the biosynthesis of constituent macromolecules, and the assembly and arrangement of these constituent parts." [GOC:bf, GOC:bm, GOC:jl]


id: GO:0039638
name: lipopolysaccharide-mediated virion attachment to host cell
namespace: biological_process
def:
  "The process by which a virion attaches to a host cell by binding to a lipopolysaccharide (LPS) on the host cell surface." [GOC:bf, GOC:bm, PMID:12837775]


id: GO:0039639
name: suppression by virus of host cell lysis in response to superinfection
namespace: biological_process
def:
  "The prevention or delay of host cell lysis by a pre-existing virus in response to a subsequent infection of the host cell by second virus." [GOC:bm, GOC:jl, PMID:22389108, PMID:9560373]


id: GO:0039640
name: cytolysis by virus via suppression of host peptidoglycan biosynthetic process
namespace: biological_process
def:
  "The killing by a virus of host cell by cytolysis, caused by a virus stopping, preventing, or reducing peptidoglycan biosynthesis in the host organism. Peptidoglycans are any of a class of glycoconjugates found in bacterial cell walls." [GOC:bf, GOC:bm]


id: GO:0039644
name: suppression by virus of host NF-kappaB transcription factor activity
namespace: biological_process
def:
  "Any process in which a virus stops, prevents, or reduces the activity of host NF-kappaB activity." [UniProtKB-KW:KW-1100, VZ:695]


id: GO:0039645
name: modulation by virus of host G1/S transition checkpoint
namespace: biological_process
def:
  "Any viral process that modulates the frequency, rate or extent of the host cell G1/S transition checkpoint." [UniProtKB-KW:KW-1078]


id: GO:0039646
name: modulation by virus of host G0/G1 transition checkpoint
namespace: biological_process
def:
  "Any viral process that modulates the frequency, rate or extent of the host cell G0/G1 transition checkpoint." [UniProtKB-KW:KW-1077]


id: GO:0039647
name: suppression by virus of host poly(A)-binding protein activity
namespace: biological_process
def:
  "Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host poly(A)-binding protein (PABP) activity. PABP binds to the poly(A) tail of mRNA to facilitate translation." [UniProtKB-KW:KW-1101]


id: GO:0039648
name: modulation by virus of host protein ubiquitination
namespace: biological_process
def:
  "Any process in which a virus modulates the frequency, rate or extent of protein ubiquitination in the host organism. Ubiquitination is the process in which one or more ubiquitin groups are added to a protein." [UniProtKB-KW:KW-1130]


id: GO:0039649
name: modulation by virus of host ubiquitin-protein ligase activity
namespace: biological_process
def:
  "The process in which a virus effects a change in host ubiquitin-protein ligase activity. Ubiquitin-protein ligase activity catalyzes the reaction: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine." [UniProtKB-KW:KW-1123]


id: GO:0039650
name: suppression by virus of host cysteine-type endopeptidase activity involved in apoptotic process
namespace: biological_process
def:
  "Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host caspase activity. Caspases are cysteine-type endopeptidases which contribute to the apoptotic process." [UniProtKB-KW:KW-1085, VZ:912]


id: GO:0039651
name: induction by virus of host cysteine-type endopeptidase activity involved in apoptotic process
namespace: biological_process
def:
  "Any process in which a virus increases the frequency, rate or extent of host cysteine-type endopeptidase activity (also called caspase activity) which contributes to the apoptotic process." [GOC:mtg_apoptosis, UniProtKB-KW:KW-1073]


id: GO:0039652
name: activation by virus of host NF-kappaB transcription factor activity
namespace: biological_process
def:
  "Any process in which a virus starts, promotes, or enhances the activity of the host transcription factor NF-kappaB." [UniProtKB-KW:KW-1074]


id: GO:0039653
name: suppression by virus of host transcription
namespace: biological_process
def:
  "Any process in which a virus stops, prevents, or reduces the activity of host DNA-dependent transcription; the cellular synthesis of RNA on a template of DNA. Viral proteins can interfere with either host RNA polymerase or with transcription factors." [UniProtKB-KW:KW-1191, VZ:1577]


id: GO:0039654
name: fusion of virus membrane with host endosome membrane
namespace: biological_process
def:
  "Fusion of a virus membrane with a host endosome membrane. Occurs after internalization of the virus through the endosomal pathway, and results in release of the virus contents into the cell." [GOC:bf, UniProtKB-KW:KW-1170, VZ:992]


id: GO:0039655
name: transport of virus in host, cell to cell via plasmodesmata
namespace: biological_process
def:
  "The transport of a virus between adjacent cells in a multicellular organism using plasmodesmata. Plasmodesma is a fine cytoplasmic channel found in all higher plants, which connects the cytoplasm of one cell to that of an adjacent cell." [UniProtKB-KW:KW-0916, VZ:1018]


id: GO:0039656
name: modulation by virus of host gene expression
namespace: biological_process
def:
  "The process in which a virus effects a change in gene expression in its host organism. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Some protein processing events may be included when they are required to form an active form of a product from an inactive precursor form." [GOC:bf]


id: GO:0039657
name: suppression by virus of host gene expression
namespace: biological_process
def:
  "Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of gene expression in the host organism. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Some protein processing events may be included when they are required to form an active form of a product from an inactive precursor form." [UniProtKB-KW:KW-1190, VZ:1582]


id: GO:0039658
name: TBK1-IKKE-DDX3 complex
namespace: cellular_component
def:
  "A protein complex containing TBK1 (TANK-binding kinase 1), IKBKE (I-Kappa-B kinase epsilon/IKKE/IKK-epsilon) and the DEAD box family RNA helicase DDX3." [PMID:18636090, VZ:719]


id: GO:0039659
name: suppression by virus of host TBK1-IKBKE-DDX3 complex activity
namespace: biological_process
def:
  "Any process in which a virus stops, prevents, or reduces the activity of the host TBK1-IKBKE-DDX3 complex." [VZ:719]


id: GO:0039660
name: structural constituent of virion
namespace: molecular_function
def:
  "The action of a molecule that contributes to the structural integrity of a virion." [GOC:bf, GOC:jl]


id: GO:0039661
name: host organelle outer membrane
namespace: cellular_component
def:
  "The outer, i.e. cytoplasm-facing in a cellular organelle, lipid bilayer of an organelle envelope, occurring in a host cell." [GOC:bf, GOC:ch]


id: GO:0039662
name: host cell outer membrane
namespace: cellular_component
def:
  "A lipid bilayer that forms the outermost layer of the cell envelope, occurring in a host cell." [GOC:bf, GOC:ch]


id: GO:0039663
name: membrane fusion involved in viral entry into host cell
namespace: biological_process
def:
  "Merging of the virion membrane and a host membrane (host plasma membrane or host organelle membrane) that is involved in the uptake of a virus into a host cell." [GOC:bf, GOC:jl, UniProtKB-KW:KW-1168]


id: GO:0039664
name: lysis of host organelle involved in viral entry into host cell
namespace: biological_process
def:
  "The viral-induced lysis of an organelle (endosome, lysosome, or caveosome) that is involved in the uptake of a virus into a host cell. Occurs once the virus is within the organelle, and results in transfer of the viral contents from the organelle compartment into the cytoplasm." [GOC:bf, GOC:jl, UniProtKB-KW:KW-1174, VZ:984]


id: GO:0039665
name: permeabilization of host organelle membrane involved in viral entry into host cell
namespace: biological_process
def:
  "Induction of organellar membrane permeabilization triggered by an interaction between the host membrane and a membrane-penetration protein associated with a viral capsid. Results in release of the virus contents from an organelle into the host cell cytoplasm." [GOC:bf, GOC:jl, UniProtKB-KW:KW-1173, VZ:985]


id: GO:0039666
name: virion attachment to host cell pilus
namespace: biological_process
def:
  "The process by which a virion attaches to a host cell by binding to a pilus on the host cell surface. Pili are retractile filaments that protrude from gram-negative bacteria. Filamentous viruses can attach to the pilus tip, whereas icosahedral viruses can attach to the pilus side." [UniProtKB-KW:KW-1175, VZ:981]


id: GO:0039667
name: viral entry into host cell via pilus retraction
namespace: biological_process
def:
  "The uptake of a virus or viral genetic material into a host cell which occurs through retraction of a virion-bound pilus." [GOC:bf, GOC:jl, VZ:981]


id: GO:0039668
name: viral entry into host cell via pilus basal pore
namespace: biological_process
def:
  "The uptake of a virus or viral genetic material into a host cell which occurs through retraction of the virion-bound pilus, followed by entry of the viral genome into the host cell through the pilus basal pore. Filamentous bacteriophages absorb to the tip of the F-pili and can enter the bacterial cell in this way." [GOC:bf, GOC:jl]


id: GO:0039669
name: viral entry into host cell via pilus retraction and membrane fusion
namespace: biological_process
def:
  "The uptake of a virus into a host cell which occurs via retraction of the viral-bound pilus to bring the virus in contact with the host cell membrane, followed by fusion of the bacteriophage membrane with the host outer membrane." [GOC:bf, GOC:jl, PMID:20427561, VZ:981]


id: GO:0039671
name: evasion by virus of host natural killer cell activity
namespace: biological_process
def:
  "Any process by which a virus avoids the effects mediated by the host organism's natural killer (NK) cells." [GOC:bf, GOC:jl, PMID:15640804, PMID:18688275, UniProtKB-KW:KW-1131]


id: GO:0039672
name: suppression by virus of host natural killer cell activation
namespace: biological_process
def:
  "Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of natural killer cell activation in the host." [GOC:bf, GOC:jl]


id: GO:0039673
name: evasion by virus of host dendritic cell activity
namespace: biological_process
def:
  "Any process by which a virus avoids the effects mediated by the host organism's dendritic cells." [GOC:bf, GOC:jl, UniProtKB-KW:KW-1118]


id: GO:0039674
name: exit of virus from host cell nucleus
namespace: biological_process
def:
  "The directed movement of the viral genome or a viral particle out of the host cell nucleus." [VZ:2177]


id: GO:0039675
name: exit of virus from host cell nucleus through nuclear pore
namespace: biological_process
def:
  "The directed movement of the viral genome or a viral particle out of the host cell nucleus through the nuclear pore." [PMID:12921991, VZ:1953]


id: GO:0039677
name: exit of virus from host cell nucleus via nuclear envelope disassembly
namespace: biological_process
def:
  "The directed movement of the viral genome or a viral particle out of the host cell nucleus that involves disruption of the nuclear membrane envelope by the virus." [VZ:2176]


id: GO:0039678
name: viral genome ejection through host cell envelope
namespace: biological_process
def:
  "Ejection by a non-enveloped prokaryotic virus of its genome into the host cytoplasm. Caudovirales carry an ejection apparatus that can be long and contractile, long and noncontractile, or short, and is able to penetrate the host cell envelope to deliver the viral genome into the host cell cytoplasm." [GOC:ch, PMID:23385786, UniProtKB-KW:KW-1171]


id: GO:0039679
name: viral occlusion body
namespace: cellular_component
def:
  "A crystalline protein matrix surrounding the nucleocapsids of some insect viruses after their release in the environment. Produced in the host cell, the occlusion body protects the infectious virion after death of the host." [UniProtKB-KW:KW-0842, VZ:1949]


id: GO:0039680
name: actin-dependent intracellular transport of virus towards nucleus
namespace: biological_process
def:
  "The directed movement of a virus, or part of a virus, towards the host cell nucleus using actin filaments." [UniProtKB-KW:KW-1178, VZ:991]


id: GO:0039682
name: rolling circle viral DNA replication
namespace: biological_process
def:
  "A process of unidirectional viral DNA replication that takes place on a circular DNA to rapidly produce numerous copies of the viral genome. Involves creating a nick in one strand of the circular DNA molecule at the origin of replication. DNA is then synthesized by DNA polymerase. Using the non-nicked strand as a template, replication proceeds around the circular DNA molecule, displacing the nicked strand as single-stranded DNA." [GOC:bf, GOC:jl, VZ:915, Wikipedia:Rolling_circle_replication]


id: GO:0039683
name: rolling circle double-stranded viral DNA replication
namespace: biological_process
def:
  "A rolling circle viral DNA replication that begins with a double-stranded viral DNA genome." [GOC:bf, GOC:jl, VZ:2676]


id: GO:0039684
name: rolling circle single-stranded viral DNA replication
namespace: biological_process
def:
  "A rolling circle viral DNA replication that begins with a single-stranded viral DNA genome." [GOC:bf, GOC:jl, VZ:1941]


id: GO:0039685
name: rolling hairpin viral DNA replication
namespace: biological_process
def:
  "A viral DNA replication process where a 3' hairpin structure in the viral single-stranded DNA (ssDNA) template serves as a primer for host enzymes to synthesize DNA." [GOC:bf, GOC:jl, VZ:2656]


id: GO:0039686
name: bidirectional double-stranded viral DNA replication
namespace: biological_process
def:
  "A viral DNA replication process where replication occurs in both directions from the starting point. This creates two replication forks, moving in opposite directions." [GOC:bf, GOC:jl, VZ:1939]


id: GO:0039687
name: viral DNA strand displacement replication
namespace: biological_process
def:
  "A viral DNA replication process where only one strand is replicated at once, and which releases a single stranded DNA (ssDNA)." [GOC:bf, GOC:jl, VZ:1940]


id: GO:0039688
name: viral double stranded DNA replication via reverse transcription
namespace: biological_process
def:
  "A DNA replication process that uses viral RNA as a template for RNA-dependent DNA polymerases (e.g. reverse transcriptase) that synthesize the new strands." [GOC:bf, GOC:jl, VZ:1938]


id: GO:0039689
name: negative stranded viral RNA replication
namespace: biological_process
def:
  "A viral genome replication process where the template genome is negative stranded, single stranded RNA ((-)ssRNA)." [GOC:bf, GOC:jl, VZ:1096]


id: GO:0039690
name: positive stranded viral RNA replication
namespace: biological_process
def:
  "A viral genome replication process where the template genome is positive stranded, single stranded RNA ((+)ssRNA). Replication of the positive strand leads to dsRNA formation, which in turn is transcribed into positive single stranded RNA." [GOC:bf, GOC:jl, VZ:1116]


id: GO:0039691
name: double stranded viral RNA replication
namespace: biological_process
def:
  "A viral genome replication process where the template genome is double stranded RNA (dsRNA). Genomic dsRNA is first transcribed into single-stranded (ss) mRNA, which is then replicated to ds-genomic RNA." [GOC:bf, GOC:jl, VZ:1936]


id: GO:0039692
name: single stranded viral RNA replication via double stranded DNA intermediate
namespace: biological_process
def:
  "A viral genome replication where the template is single-stranded RNA (ssRNA), and which proceeds via a double stranded DNA (dsDNA) intermediate molecule. Viral genomic RNA is first reverse transcribed into dsDNA, which integrates into the host chromosomal DNA, where it is transcribed by host RNA polymerase II." [GOC:bf, GOC:jl, ISBN:0198506732, VZ:1937]


id: GO:0039697
name: negative stranded viral RNA transcription
namespace: biological_process
def:
  "A viral transcription process that uses negative stranded (-) single stranded (ss) RNA as a template." [VZ:1096]


id: GO:0039698
name: polyadenylation of viral mRNA by polymerase stuttering
namespace: biological_process
def:
  "Polyadenylation of viral mRNA through a polymerase stuttering mechanism. The stop signal present at the end of each gene comprises a stretch of uridine on which the viral polymerase acquires a stuttering behavior: after each adenine inserted, the polymerase moves back one nucleotide along with the mRNA. It resumes transcription adding a new adenine, then again moves back, thereby producing a polyA tail." [VZ:1916]


id: GO:0039699
name: viral mRNA cap methylation
namespace: biological_process
def:
  "Methylation of the 2'-O-ribose of the first or second transcribed nucleotide of a viral mRNA. Methylation allows evasion of the host innate immune response, which degrades cap0 (non-methylated) mRNAs." [UniProtKB-KW:KW-1196]


id: GO:0039700
name: fusion of viral membrane with host outer nuclear membrane
namespace: biological_process
def:
  "Fusion of a viral primary envelope with the host outer nuclear membrane during nuclear egress. The transitory primary envelope is acquired by the virus as it buds at the inner nuclear membrane and gains access to the perinuclear space. This membrane is lost by fusing with the host outer nuclear membrane during nuclear exit." [PMID:23057731, UniProtKB-KW:KW-1181]


id: GO:0039701
name: microtubule-dependent intracellular transport of viral material towards cell periphery
namespace: biological_process
def:
  "The directed movement of the viral genome or a viral particle towards the cell periphery using host microtubules. Mostly used by viruses that replicate their genome near or in the nucleus to allows newly assembled viral progeny to reach the plasma membrane." [UniProtKB-KW:KW-1189, VZ:1816]


id: GO:0039702
name: viral budding via host ESCRT complex
namespace: biological_process
def:
  "Viral budding which uses a host ESCRT protein complex, or complexes, to mediate the budding process." [UniProtKB-KW:KW-1187, VZ:1536]


id: GO:0039703
name: RNA replication
namespace: biological_process
def:
  "The cellular metabolic process in which a cell duplicates one or more molecules of RNA." [GOC:bf, GOC:jl]


id: GO:0039704
name: viral translational shunt
namespace: biological_process
def:
  "A viral translation initiation mechanism where ribosomes are loaded onto viral mRNA at the 5'-cap structure and start scanning for a short distance before by-passing the large internal leader region and initiating at a downstream start site." [PMID:15827182, PMID:18195037, VZ:608]


id: GO:0039705
name: viral translational readthrough
namespace: biological_process
def:
  "The continuation of translation of a viral mRNA beyond a stop codon by the use of a special tRNA that recognizes the UAG and UGA codons as modified amino acids, rather than as termination codons." [GOC:bf, GOC:ch, GOC:jl, PMID:10839817, VZ:859]


id: GO:0039706
name: co-receptor binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with a coreceptor. A coreceptor acts in cooperation with a primary receptor to transmit a signal within the cell." [GOC:bf, GOC:jl]


id: GO:0039707
name: pore formation by virus in membrane of host cell
namespace: biological_process
def:
  "The aggregation, arrangement and bonding together of a set of components by a virus to form a pore complex in a membrane of a host organism." [GOC:bf, GOC:jl, PMID:12972148, UniProtKB-KW:KW-1182]


id: GO:0039708
name: nuclear capsid assembly
namespace: biological_process
def:
  "The assembly of a virus capsid that occurs in the nucleus. The assembly of large icosahedral shells for herpesviridae and adenoviridae requires structural proteins that act as chaperones for assembly." [VZ:1516]


id: GO:0039710
name: cytoplasmic icosahedral capsid assembly
namespace: biological_process
def:
  "The assembly of an icosahedral viral capsid in the cytoplasm. Often occurs by assembling around the viral genome." [VZ:1950]


id: GO:0039711
name: cytoplasmic helical capsid assembly
namespace: biological_process
def:
  "The assembly of a helical viral capsid in the cytoplasm. Occurs by assembling around the viral genome." [VZ:1950]


id: GO:0039712
name: induction by virus of host catalytic activity
namespace: biological_process
def:
  "Any viral process that activates or increases the frequency, rate or extent of host catalytic activity." [GOC:bf, GOC:jl]


id: GO:0039713
name: viral factory
namespace: cellular_component
def:
  "An intracellular compartment in a host cell which increases the efficiency of viral replication and/or assembly, and shields the virus from host defenses. Viral factories can be either cytoplasmic or nuclear and often arise from extensive rearrangement of host cell cytoskeletal and/or cell membrane compartments." [PMID:22440839, VZ:1951]


id: GO:0039716
name: viroplasm viral factory
namespace: cellular_component
def:
  "A cytoplasmic viral factory that is electron dense due to high levels of viral RNA. Produced by nucleo-cytoplasmic large DNA viruses (NCLDV) like Poxviridae, Asfarviridae and Iridoviridae, and dsRNA viruses like Reoviridae." [VZ:1951, Wikipedia:Viroplasm]


id: GO:0039717
name: spherule viral factory
namespace: cellular_component
def:
  "A cytoplasmic viral factory which is a 50-400nm diameter membrane invagination. Spherules can appear on several enveloped cellular components depending on the virus." [VZ:1951]


id: GO:0039718
name: double membrane vesicle viral factory
namespace: cellular_component
def:
  "A cytoplasmic viral factory that consists of a double-membrane bound vesicle. Has a diameter of 200-300nm and is derived from the endoplasmic reticulum or Golgi apparatus. Produced by Picornaviridae, Nidovirales, Arteriviridae and Coronaviridae." [PMID:22440839, VZ:1951]


id: GO:0039719
name: tube viral factory
namespace: cellular_component
def:
  "A cytoplasmic viral factory derived from the Golgi in which Bunyaviridae replication takes place. Tubes are membranous structures close to the assembly and budding sites, and their function may be to connect viral replication and morphogenesis inside viral factories." [VZ:1951]


id: GO:0039720
name: virogenic stroma
namespace: cellular_component
def:
  "A nuclear viral factory formed by Baculoviruses. A vesicular structure in which virions are assembled." [PMID:13358757, PMID:1433508, VZ:1951]


id: GO:0039721
name: peristromal region viral factory
namespace: cellular_component
def:
  "A nuclear viral factory formed at the periphery of the host cell nucleus by Baculoviruses." [PMID:18434402, VZ:1951]


id: GO:0039722
name: suppression by virus of host toll-like receptor signaling pathway
namespace: biological_process
def:
  "Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of toll-like receptor (TLR) signaling in the host organism." [UniProtKB-KW:KW-1225]


id: GO:0039723
name: suppression by virus of host TBK1 activity
namespace: biological_process
def:
  "Any process in which a virus stops, prevents, or reduces the activity of the host serine/threonine kinase TBK1." [PR:000001779, UniProtKB-KW:KW-1223]


id: GO:0039724
name: suppression by virus of host IKBKE activity
namespace: biological_process
def:
  "Any process in which a virus stops, prevents, or reduces the activity of the host I-kappa-B kinase epsilon (IKBKE/IKK-epsilon/IKK-E)." [PR:000001778, UniProtKB-KW:KW-1224]


id: GO:0040001
name: establishment of mitotic spindle localization
namespace: biological_process
def:
  "The cell cycle process in which the directed movement of the mitotic spindle to a specific location in the cell occurs." [GOC:ai]


id: GO:0040002
name: collagen and cuticulin-based cuticle development
namespace: biological_process
def:
  "Synthesis and deposition of a collagen and cuticulin-based noncellular, hardened, or membranous secretion from an epithelial sheet. An example of this process is found in Caenorhabditis elegans." [GOC:mtg_sensu]


id: GO:0040003
name: chitin-based cuticle development
namespace: biological_process
def:
  "Synthesis and deposition of a chitin-based noncellular, hardened, or membranous secretion from an epithelial sheet. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu]


id: GO:0040004
name: collagen and cuticulin-based cuticle attachment to epithelium
namespace: biological_process
def:
  "Attaching of a collagen and cuticulin-based cuticle to the epithelium underlying it. An example of this process is found in Caenorhabditis elegans." [GOC:ems, GOC:mtg_sensu]


id: GO:0040005
name: chitin-based cuticle attachment to epithelium
namespace: biological_process
def:
  "Attaching of a chitin-containing cuticle to the epithelium underlying it. An example of this process is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu]


id: GO:0040006
name: obsolete protein-based cuticle attachment to epithelium
namespace: biological_process
def:
  "OBSOLETE. Attaching of a protein-based cuticle to the epithelium underlying it." [GOC:jl, GOC:mtg_sensu]


id: GO:0040007
name: growth
namespace: biological_process
def:
  "The increase in size or mass of an entire organism, a part of an organism or a cell." [GOC:bf, GOC:ma]


id: GO:0040008
name: regulation of growth
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of the growth of all or part of an organism so that it occurs at its proper speed, either globally or in a specific part of the organism's development." [GOC:ems, GOC:mah]


id: GO:0040012
name: regulation of locomotion
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of locomotion of a cell or organism." [GOC:ems]


id: GO:0040013
name: negative regulation of locomotion
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of locomotion of a cell or organism." [GOC:go_curators]


id: GO:0040014
name: regulation of multicellular organism growth
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of growth of the body of an organism so that it reaches its usual body size." [GOC:dph, GOC:ems, GOC:tb]


id: GO:0040015
name: negative regulation of multicellular organism growth
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of growth of an organism to reach its usual body size." [GOC:dph, GOC:ems, GOC:tb]


id: GO:0040017
name: positive regulation of locomotion
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of locomotion of a cell or organism." [GOC:go_curators]


id: GO:0040018
name: positive regulation of multicellular organism growth
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of growth of an organism to reach its usual body size." [GOC:dph, GOC:go_curators, GOC:tb]


id: GO:0040019
name: positive regulation of embryonic development
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of embryonic development." [GOC:go_curators]


id: GO:0040020
name: regulation of meiotic nuclear division
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of meiosis, the process in which the nucleus of a diploid cell divides twice forming four haploid cells, one or more of which usually function as gametes." [GOC:ems, GOC:ma]


id: GO:0040022
name: feminization of hermaphroditic germ-line
namespace: biological_process
def:
  "The determination of female sex and sexual phenotype in the germ-line of the hermaphrodite." [GOC:ems]


id: GO:0040024
name: dauer larval development
namespace: biological_process
def:
  "The process whose specific outcome is the progression of the dauer larva over time, through the facultative diapause of the dauer (enduring) larval stage, with specialized traits adapted for dispersal and long-term survival, with elevated stress resistance and without feeding." [GOC:ems, ISBN:087969307X]


id: GO:0040025
name: vulval development
namespace: biological_process
def:
  "The process whose specific outcome is the progression of the egg-laying organ of female and hermaphrodite nematodes over time, from its formation to the mature structure. In nematodes, the vulva is formed from ventral epidermal cells during larval stages to give rise to a fully formed vulva in the adult." [GOC:ems, GOC:kmv, ISBN:087969307X]


id: GO:0040026
name: positive regulation of vulval development
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of development of the vulva. Vulval development is the process whose specific outcome is the progression of the egg-laying organ of female and hermaphrodite nematodes over time, from its formation to the mature structure. In nematodes, the vulva is formed from ventral epidermal cells during larval stages to give rise to a fully formed vulva in the adult." [GOC:ems, GOC:kmv]


id: GO:0040027
name: negative regulation of vulval development
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of development of the vulva. Vulval development is the process whose specific outcome is the progression of the egg-laying organ of female and hermaphrodite nematodes over time, from its formation to the mature structure. In nematodes, the vulva is formed from ventral epidermal cells during larval stages to give rise to a fully formed vulva in the adult." [GOC:ems, GOC:kmv]


id: GO:0040028
name: regulation of vulval development
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of development of the vulva. Vulval development is the process whose specific outcome is the progression of the egg-laying organ of female and hermaphrodite nematodes over time, from its formation to the mature structure. In nematodes, the vulva is formed from ventral epidermal cells during larval stages to give rise to a fully formed vulva in the adult." [GOC:kmv, GOC:ma]


id: GO:0040029
name: regulation of gene expression, epigenetic
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of gene expression; the process is mitotically or meiotically heritable, or is stably self-propagated in the cytoplasm of a resting cell, and does not entail a change in DNA sequence." [PMID:10521337, PMID:11498582]


id: GO:0040030
name: regulation of molecular function, epigenetic
namespace: biological_process
def:
  "Any heritable epigenetic process that modulates the frequency, rate or extent of protein function by self-perpetuating conformational conversions of normal proteins in healthy cells. This is distinct from, though mechanistically analogous to, disease states associated with prion propagation and amyloidogenesis. A single protein, if it carries a glutamine/asparagine-rich ('prion') domain, can sometimes stably exist in at least two distinct physical states, each associated with a different phenotype; propagation of one of these traits is achieved by a self-perpetuating change in the protein from one form to the other, mediated by conformational changes in the glutamine/asparagine-rich domain. Prion domains are both modular and transferable to other proteins, on which they can confer a heritable epigenetic alteration of function; existing bioinformatics data indicate that they are rare in non-eukarya, but common in eukarya." [GOC:dph, GOC:ems, GOC:tb, PMID:10611975, PMID:11050225, PMID:11447696, PMID:11685242, PMID:11782551]


id: GO:0040031
name: snRNA modification
namespace: biological_process
def:
  "The covalent alteration of one or more nucleotides within snRNA, resulting in a change in the properties of the snRNA." [GOC:jl]


id: GO:0040032
name: post-embryonic body morphogenesis
namespace: biological_process
def:
  "The process in which the anatomical structures of the post-embryonic soma are generated and organized." [GOC:ems, ISBN:0140512888]


id: GO:0040033
name: negative regulation of translation, ncRNA-mediated
namespace: biological_process
def:
  "Any process, mediated by small non-coding RNAs, that stops, prevents or reduces the rate that mRNAs are effectively translated into protein." [GOC:dph, GOC:ems, GOC:tb]


id: GO:0040034
name: regulation of development, heterochronic
namespace: biological_process
def:
  "Any process that modulates the consistent predetermined time point at which an integrated living unit or organism progresses from an initial condition to a later condition and the rate at which this time point is reached." [PMID:9442909]


id: GO:0040035
name: hermaphrodite genitalia development
namespace: biological_process
def:
  "The process whose specific outcome is the progression of the hermaphrodite genitalia over time, from formation to the mature structures." [GOC:ems, ISBN:0140512888]


id: GO:0040036
name: regulation of fibroblast growth factor receptor signaling pathway
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of fibroblast growth factor receptor signaling pathway activity." [GOC:go_curators]


id: GO:0040037
name: negative regulation of fibroblast growth factor receptor signaling pathway
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of fibroblast growth factor receptor signaling pathway activity." [GOC:go_curators]


id: GO:0040038
name: polar body extrusion after meiotic divisions
namespace: biological_process
def:
  "The cell cycle process in which two small cells are generated, as byproducts destined to degenerate, as a result of the first and second meiotic divisions of a primary oocyte during its development to a mature ovum. One polar body is formed in the first division of meiosis and the other in the second division; at each division, the cytoplasm divides unequally, so that the polar body is of much smaller size than the developing oocyte. At the second division in which a polar body is formed, the polar body and the developing oocyte each contain a haploid set of chromosomes." [GOC:ems, ISBN:0198506732]


id: GO:0040039
name: inductive cell migration
namespace: biological_process
def:
  "Migration of a cell in a multicellular organism that, having changed its location, is required to induce normal properties in one or more cells at its new location. An example of this would be the distal tip cells of Caenorhabditis elegans." [ISBN:087969307X, ISBN:0879694882]


id: GO:0042000
name: translocation of peptides or proteins into host
namespace: biological_process
def:
  "The directed movement of peptides or proteins produced by an organism to a location inside its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:cc]


id: GO:0042001
name: hermaphrodite somatic sex determination
namespace: biological_process
def:
  "The determination of sex and sexual phenotypes in a hermaphroditic organism's soma. An example of this is found in Caenorhabditis elegans." [GOC:ems]


id: GO:0042003
name: masculinization of hermaphrodite soma
namespace: biological_process
def:
  "Promotion of male sex and sexual phenotypes in the hermaphroditic nematode soma. An example of this is found in Caenorhabditis elegans." [GOC:ems]


id: GO:0042004
name: feminization of hermaphrodite soma
namespace: biological_process
def:
  "Promotion of female sex and sexual phenotypes in the hermaphroditic soma. An example of this is found in Caenorhabditis elegans." [GOC:ems]


id: GO:0042006
name: masculinization of hermaphroditic germ-line
namespace: biological_process
def:
  "The determination of male sex and sexual phenotype in the germ-line of the hermaphrodite. An example of this is found in Caenorhabditis elegans." [GOC:ems]


id: GO:0042008
name: interleukin-18 receptor activity
namespace: molecular_function
def:
  "Combining with interleukin-18 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:jl, GOC:signaling]


id: GO:0042010
name: interleukin-15 receptor activity
namespace: molecular_function
def:
  "Combining with interleukin-15 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:jl, GOC:signaling]


id: GO:0042012
name: interleukin-16 receptor activity
namespace: molecular_function
def:
  "Combining with interleukin-16 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:jl, GOC:signaling]


id: GO:0042014
name: interleukin-19 receptor activity
namespace: molecular_function
def:
  "Combining with interleukin-19 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:jl, GOC:signaling]


id: GO:0042016
name: interleukin-20 receptor activity
namespace: molecular_function
def:
  "Combining with interleukin-20 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:jl, GOC:signaling]


id: GO:0042018
name: interleukin-22 receptor activity
namespace: molecular_function
def:
  "Combining with interleukin-22 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:jl, GOC:signaling]


id: GO:0042020
name: interleukin-23 receptor activity
namespace: molecular_function
def:
  "Combining with interleukin-23 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:jl, GOC:signaling]


id: GO:0042021
name: granulocyte macrophage colony-stimulating factor complex binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with the granulocyte macrophage colony-stimulating factor complex." [GOC:ai]


id: GO:0042022
name: interleukin-12 receptor complex
namespace: cellular_component
def:
  "A protein complex that binds interleukin-12; comprises a beta1 and a beta2 subunit." [GOC:ebc, GOC:mah, PMID:10971505]


id: GO:0042023
name: DNA endoreduplication
namespace: biological_process
def:
  "Regulated re-replication of DNA within a single cell cycle, resulting in an increased cell ploidy. An example of this process occurs in the synthesis of Drosophila salivary gland cell polytene chromosomes." [GOC:jl, GOC:vw]


id: GO:0042025
name: host cell nucleus
namespace: cellular_component
def:
  "A membrane-bounded organelle as it is found in the host cell in which chromosomes are housed and replicated. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:pamgo_curators]


id: GO:0042026
name: protein refolding
namespace: biological_process
def:
  "The process carried out by a cell that restores the biological activity of an unfolded or misfolded protein, using helper proteins such as chaperones." [GOC:mb]


id: GO:0042027
name: obsolete cyclophilin-type peptidyl-prolyl cis-trans isomerase activity
namespace: molecular_function
def:
  "OBSOLETE. Catalysis of the reaction: peptidylproline (omega=180) = peptidylproline (omega=0)." [EC:5.2.1.8]


id: GO:0042029
name: obsolete fibrolase activity
namespace: molecular_function
def:
  "OBSOLETE. Catalysis of the cleavage of 14-Ala-Leu-15 in insulin B chain and cleavage of 413-Lys-Leu-414 in alpha chain of fibrinogen." [EC:3.4.24.72, PMID:7725320]


id: GO:0042030
name: ATPase inhibitor activity
namespace: molecular_function
def:
  "Stops, prevents or reduces the activity of any enzyme that catalyzes the hydrolysis of ATP to ADP and orthophosphate." [GOC:jl]


id: GO:0042031
name: obsolete angiotensin-converting enzyme inhibitor activity
namespace: molecular_function
def:
  "OBSOLETE. Stops, prevents or reduces the activity of angiotensin-converting enzyme, thereby preventing the synthesis of angiotensin II from its precursor, angiotensin I." [GOC:jl]


id: GO:0042033
name: chemokine biosynthetic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of chemokines, any member of a family of small chemotactic cytokines; their name is derived from their ability to induce directed chemotaxis in nearby responsive cells. All chemokines possess a number of conserved cysteine residues involved in intramolecular disulfide bond formation. Some chemokines are considered pro-inflammatory and can be induced during an immune response to recruit cells of the immune system to a site of infection, while others are considered homeostatic and are involved in controlling the migration of cells during normal processes of tissue maintenance or development. Chemokines are found in all vertebrates, some viruses and some bacteria." [GOC:BHF, GOC:rl, http://en.wikipedia.org/wiki/Chemokine, ISBN:0198506732, PMID:12183377]


id: GO:0042034
name: peptidyl-L-lysine methyl ester biosynthetic process from peptidyl-lysine
namespace: biological_process
def:
  "The modification of a C-terminal peptidyl-lysine to form peptidyl-L-lysine methyl ester." [RESID:AA0318]


id: GO:0042035
name: regulation of cytokine biosynthetic process
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cytokines." [GOC:go_curators]


id: GO:0042036
name: negative regulation of cytokine biosynthetic process
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cytokines." [GOC:go_curators]


id: GO:0042037
name: peptidyl-histidine methylation, to form pros-methylhistidine
namespace: biological_process
def:
  "The methylation of peptidyl-L-histidine to form peptidyl-L-3'-methyl-L-histidine (otherwise known as pi-methylhistidine, pros-methylhistidine)." [RESID:AA0073]


id: GO:0042038
name: peptidyl-histidine methylation, to form tele-methylhistidine
namespace: biological_process
def:
  "The methylation of peptidyl-L-histidine to form peptidyl-L-1'-methyl-L-histidine (otherwise known as tau-methylhistidine, tele-methylhistidine)." [RESID:AA0317]


id: GO:0042043
name: neurexin family protein binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with neurexins, synaptic cell surface proteins related to latrotoxin receptor, laminin and agrin. Neurexins act as cell recognition molecules at nerve terminals." [GOC:curators, GOC:pr, PMID:18923512]


id: GO:0042044
name: fluid transport
namespace: biological_process
def:
  "The directed movement of substances that are in liquid form in normal living conditions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]


id: GO:0042046
name: W-molybdopterin cofactor metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving the W-molybdopterin cofactor, essential for the catalytic activity of some enzymes. The cofactor consists of a mononuclear tungsten ion (W) coordinated by one or two molybdopterin ligands." [ISSN:09498257]


id: GO:0042047
name: W-molybdopterin cofactor biosynthetic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of the W-molybdopterin cofactor, essential for the catalytic activity of some enzymes. The cofactor consists of a mononuclear tungsten ion (W) coordinated by one or two molybdopterin ligands." [ISSN:09498257]


id: GO:0042049
name: cellular acyl-CoA homeostasis
namespace: biological_process
def:
  "Any process involved in the maintenance of an internal steady state of acyl-CoA within a cell or between a cell and its external environment." [GOC:ai, GOC:dph, GOC:tb]


id: GO:0042051
name: compound eye photoreceptor development
namespace: biological_process
def:
  "The process whose specific outcome is the progression of a light-responsive receptor in the compound eye over time, from its formation to the mature structure." [GOC:bf]


id: GO:0042052
name: rhabdomere development
namespace: biological_process
def:
  "The assembly and arrangement of a rhabdomere within a cell. The rhabdomere is the organelle on the apical surface of a photoreceptor cell that contains the visual pigments." [PMID:3076112, PMID:3937883]


id: GO:0042053
name: regulation of dopamine metabolic process
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving dopamine." [GOC:go_curators]


id: GO:0042054
name: histone methyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: S-adenosyl-L-methionine + histone = S-adenosyl-L-homocysteine + methyl-histone. Histone methylation generally occurs on either an arginine or lysine residue." [EC:2.1.1.43]


id: GO:0042056
name: chemoattractant activity
namespace: molecular_function
def:
  "Providing the environmental signal that initiates the directed movement of a motile cell or organism towards a higher concentration of that signal." [GOC:go_curators, ISBN:0198506732]


id: GO:0042057
name: obsolete transforming growth factor beta receptor anchoring activity
namespace: molecular_function
def:
  "OBSOLETE. Binds to transforming growth factor beta receptor and anchors it to a particular subcellular location." [GOC:ai]


id: GO:0042058
name: regulation of epidermal growth factor receptor signaling pathway
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of epidermal growth factor receptor signaling pathway activity." [GOC:go_curators]


id: GO:0042059
name: negative regulation of epidermal growth factor receptor signaling pathway
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of epidermal growth factor receptor signaling pathway activity." [GOC:go_curators]


id: GO:0042060
name: wound healing
namespace: biological_process
def:
  "The series of events that restore integrity to a damaged tissue, following an injury." [GOC:bf, PMID:15269788]


id: GO:0042062
name: long-term strengthening of neuromuscular junction
namespace: biological_process
def:
  "Any process that results in an increase in the efficacy of transmission at a neuromuscular synapse." [GO_REF:0000021, GOC:mtg_15jun06_goc\:pd]


id: GO:0042063
name: gliogenesis
namespace: biological_process
def:
  "The process that results in the generation of glial cells. This includes the production of glial progenitors and their differentiation into mature glia." [GOC:dgh, GOC:jid]


id: GO:0042065
name: glial cell growth
namespace: biological_process
def:
  "Growth of glial cells, non-neuronal cells that provide support and nutrition, maintain homeostasis, form myelin, and participate in signal transmission in the nervous system." [GOC:dph, GOC:isa_complete, GOC:jid]


id: GO:0042066
name: perineurial glial growth
namespace: biological_process
def:
  "Glial cell growth that occurs in the perineurium, a cell layer that ensheaths projections of peripheral nerves, such as motor axons." [GOC:mah, PMID:11517334, PMID:18176560]


id: GO:0042067
name: establishment of ommatidial planar polarity
namespace: biological_process
def:
  "The specification of polarized ommatidia. Ommatidia occur in two chiral forms. The trapezoidal arrangement of photoreceptors in the dorsal part of the eye is the mirror image of that in the ventral part." [GOC:ascb_2009, GOC:dph, GOC:tb, PMID:3076112, PMID:3937883]


id: GO:0042068
name: regulation of pteridine metabolic process
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving pteridine." [GOC:go_curators]


id: GO:0042069
name: regulation of catecholamine metabolic process
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving catecholamines." [GOC:go_curators]


id: GO:0042070
name: maintenance of oocyte nucleus location involved in oocyte dorsal/ventral axis specification
namespace: biological_process
def:
  "Maintenance of the oocyte nucleus in a particular position within the cell during the establishment and maintenance of the axes of the oocyte. An example of this process is found In Drosophila melanogaster." [GOC:dph, GOC:mah, GOC:mtg_sensu, GOC:tb]


id: GO:0042071
name: leucokinin receptor activity
namespace: molecular_function
def:
  "Combining with a leucokinin, any of several octapeptide hormones found in insects, and transmitting the signal to initiate a change in cell activity." [GOC:mah, GOC:signaling, PMID:2716741]


id: GO:0042073
name: intraciliary transport
namespace: biological_process
def:
  "The bidirectional movement of large protein complexes along microtubules within a cilium, mediated by motor proteins." [GOC:cilia, GOC:kmv, PMID:17981739, PMID:18180368, PMID:22869374]


id: GO:0042074
name: cell migration involved in gastrulation
namespace: biological_process
def:
  "The migration of individual cells within the blastocyst to help establish the multi-layered body plan of the organism (gastrulation). For example, the migration of cells from the surface to the interior of the embryo (ingression)." [GOC:jl, http://www.cellmigration.org/, ISBN:0878932437]


id: GO:0042075
namespace: biological_process
name:
  nickel incorporation into nickel-iron-sulfur cluster via pentakis-L-cysteinyl L-histidino nickel tetrairon pentasulfide

def:
  "The incorporation of nickel into a nickel-iron-sulfur cluster via pentakis-L-cysteinyl L-histidino nickel tetrairon pentasulfide, found in carbon monoxide dehydrogenase." [RESID:AA0310]


id: GO:0042076
name: protein phosphate-linked glycosylation
namespace: biological_process
def:
  "The glycosylation of peptidyl-amino acids through a phosphoester bond forming, for example, GlcNAc-alpha-1-P-Ser residues." [PMID:7499424]


id: GO:0042077
name: protein phosphate-linked glycosylation via serine
namespace: biological_process
def:
  "The glycosylation of peptidyl-serine through a phosphoester bond forming, for example, GlcNAc-alpha-1-P-Ser residues." [GOC:mah]


id: GO:0042078
name: germ-line stem cell division
namespace: biological_process
def:
  "The self-renewing division of a germline stem cell to produce a daughter stem cell and a daughter germ cell, which will divide to form the gametes." [GOC:jid, PMID:2279698]


id: GO:0042081
name: GSI anchor metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving glycosylsphingolipidinositol (GSI) anchors, which attach membrane proteins to the lipid bilayer of the cell membrane." [GOC:go_curators]


id: GO:0042082
name: GSI anchor biosynthetic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of a glycosylsphingolipidinositol (GSI) anchor that attaches some membrane proteins to the lipid bilayer of the cell membrane. The sphingolipid group is linked, via the C-6 hydroxyl residue of inositol to a carbohydrate chain which is itself linked to the protein via a ethanolamine phosphate group, its amino group forming an amide linkage with the C-terminal carboxyl of the protein. Some GSI anchors have variants on this canonical linkage." [GOC:go_curators, GOC:jsg]


id: GO:0042083
name: 5,10-methylenetetrahydrofolate-dependent methyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the transfer of a methyl group to an acceptor molecule; dependent on the presence of 5,10-methylenetetrahydrofolate." [GOC:ai]


id: GO:0042084
name: 5-methyltetrahydrofolate-dependent methyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the transfer of a methyl group to an acceptor molecule; dependent on the presence of 5-methyltetrahydrofolate." [GOC:ai]


id: GO:0042085
name: 5-methyltetrahydropteroyltri-L-glutamate-dependent methyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the transfer of a methyl group to an acceptor molecule; dependent on the presence of 5-methyltetrahydropteroyltri-L-glutamate." [GOC:ai]


id: GO:0042086
name: 5-methyl-5,6,7,8-tetrahydromethanopterin-dependent methyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the transfer of a methyl group to an acceptor molecule, dependent on the presence of 5-methyl-5,6,7,8-tetrahydromethanopterin." [GOC:ai]


id: GO:0042088
name: T-helper 1 type immune response
namespace: biological_process
def:
  "An immune response which is associated with resistance to intracellular bacteria, fungi, and protozoa, and pathological conditions such as arthritis, and which is typically orchestrated by the production of particular cytokines by T-helper 1 cells, most notably interferon-gamma, IL-2, and lymphotoxin." [GOC:add, ISBN:0781735149]


id: GO:0042089
name: cytokine biosynthetic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of cytokines, any of a group of proteins that function to control the survival, growth and differentiation of tissues and cells, and which have autocrine and paracrine activity." [GOC:bf, ISBN:0198506732, ISBN:0198599471]


id: GO:0042090
name: interleukin-12 biosynthetic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of interleukin-12." [GOC:go_curators]


id: GO:0042091
name: interleukin-10 biosynthetic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of interleukin-10." [GOC:go_curators]


id: GO:0042092
name: type 2 immune response
namespace: biological_process
def:
  "An immune response which is associated with resistance to extracellular organisms such as helminths and pathological conditions such as allergy, which is orchestrated by the production of particular cytokines, most notably IL-4, IL-5, IL-10, and IL-13, by any of a variety of cell types including T-helper 2 cells, eosinophils, basophils, mast cells, and nuocytes, resulting in enhanced production of certain antibody isotypes and other effects." [GOC:add, ISBN:0781735149, PMID:18000958, PMID:18007680, PMID:20065995, PMID:20200518]


id: GO:0042093
name: T-helper cell differentiation
namespace: biological_process
def:
  "The process in which a relatively unspecialized thymocyte acquires specialized features of a T-helper cell." [GOC:ebc]


id: GO:0042094
name: interleukin-2 biosynthetic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of interleukin-2." [GOC:go_curators]


id: GO:0042095
name: interferon-gamma biosynthetic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of interferon-gamma. Interferon gamma is the only member of the type II interferon found so far." [GOC:go_curators, PR:000000017]


id: GO:0042097
name: interleukin-4 biosynthetic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of interleukin-4." [GOC:go_curators]


id: GO:0042101
name: T cell receptor complex
namespace: cellular_component
def:
  "A protein complex that contains a disulfide-linked heterodimer of T cell receptor (TCR) chains, which are members of the immunoglobulin superfamily, and mediates antigen recognition, ultimately resulting in T cell activation. The TCR heterodimer is associated with the CD3 complex, which consists of the nonpolymorphic polypeptides gamma, delta, epsilon, zeta, and, in some cases, eta (an RNA splice variant of zeta) or Fc epsilon chains." [GOC:mah, ISBN:0781735149]


id: GO:0042103
name: positive regulation of T cell homeostatic proliferation
namespace: biological_process
def:
  "Any process that activates or increases the rate or extent of resting T cell proliferation." [GOC:jl]


id: GO:0042104
name: positive regulation of activated T cell proliferation
namespace: biological_process
def:
  "Any process that activates or increases the rate or extent of activated T cell proliferation." [GOC:jl]


id: GO:0042105
name: alpha-beta T cell receptor complex
namespace: cellular_component
def:
  "A T cell receptor complex in which the TCR heterodimer comprises alpha and beta chains, associated with the CD3 complex; recognizes a complex consisting of an antigen-derived peptide bound to a class I or class II MHC protein." [GOC:mah, ISBN:0781735149]


id: GO:0042106
name: gamma-delta T cell receptor complex
namespace: cellular_component
def:
  "A T cell receptor complex in which the TCR heterodimer comprises gamma and delta chains, associated with the CD3 complex; recognizes antigen directly, without a requirement for processing and presentation by an MHC protein." [GOC:mah, ISBN:0781735149]


id: GO:0042107
name: cytokine metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving cytokines, any of a group of proteins or glycoproteins that function to control the survival, growth and differentiation of tissues and cells, and which have autocrine and paracrine activity." [GO_REF:0000022, GOC:bf, GOC:BHF, GOC:go_curators, GOC:mtg_15nov05, ISBN:0198599471]


id: GO:0042108
name: positive regulation of cytokine biosynthetic process
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cytokines." [GOC:go_curators]


id: GO:0042109
name: lymphotoxin A biosynthetic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of the cytokine lymphotoxin A." [GOC:jl]


id: GO:0042110
name: T cell activation
namespace: biological_process
def:
  "The change in morphology and behavior of a mature or immature T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific." [GOC:mgi_curators, ISBN:0781735140]


id: GO:0042113
name: B cell activation
namespace: biological_process
def:
  "The change in morphology and behavior of a mature or immature B cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific." [GOC:mgi_curators, ISBN:0781735140]


id: GO:0042116
name: macrophage activation
namespace: biological_process
def:
  "A change in morphology and behavior of a macrophage resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor." [GOC:mgi_curators, ISBN:0781735149, PMID:14506301]


id: GO:0042117
name: monocyte activation
namespace: biological_process
def:
  "The change in morphology and behavior of a monocyte resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor." [GOC:mgi_curators, ISBN:0781735149]


id: GO:0042118
name: endothelial cell activation
namespace: biological_process
def:
  "The change in morphology and behavior of an endothelial cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor." [GOC:mgi_curators, ISBN:0781735149, PMID:12851652, PMID:14581484]


id: GO:0042119
name: neutrophil activation
namespace: biological_process
def:
  "The change in morphology and behavior of a neutrophil resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor." [GOC:mgi_curators, ISBN:0781735149]


id: GO:0042120
name: alginic acid metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving alginic acid, a hydrophilic polysaccharide occurring in, for example, the cell walls of brown algae (brown seaweeds)." [ISBN:0198506732]


id: GO:0042121
name: alginic acid biosynthetic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of alginic acid, a hydrophilic polysaccharide occurring in, for example, the cell walls of brown algae (brown seaweeds)." [ISBN:0198506732]


id: GO:0042122
name: alginic acid catabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the breakdown of alginic acid, a hydrophilic polysaccharide occurring in, for example, the cell walls of brown algae (brown seaweeds)." [ISBN:0198506732]


id: GO:0042123
name: glucanosyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the splitting and linkage of glucan molecules, resulting in glucan chain elongation." [GOC:jl]


id: GO:0042124
name: 1,3-beta-glucanosyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the splitting and linkage of (1->3)-beta-D-glucan molecules, resulting in (1->3)-beta-D-glucan chain elongation." [GOC:jl, PMID:10809732]


id: GO:0042126
name: nitrate metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving nitrates, inorganic or organic salts and esters of nitric acid." [GOC:jl]


id: GO:0042128
name: nitrate assimilation
namespace: biological_process
def:
  "The nitrogen metabolic process that encompasses the uptake of nitrate from the environment and reduction to ammonia, and results in the incorporation of nitrogen derived from nitrate into cellular substances." [GOC:das, GOC:mah, PMID:10542156, PMID:8122899]


id: GO:0042132
name: fructose 1,6-bisphosphate 1-phosphatase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: D-fructose 1,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate." [EC:3.1.3.11]


id: GO:0042133
name: neurotransmitter metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving neurotransmitters, any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell." [CHEBI:25512, GOC:jl]


id: GO:0042135
name: neurotransmitter catabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the breakdown of any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell." [CHEBI:25512, GOC:jl]


id: GO:0042136
name: neurotransmitter biosynthetic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell." [CHEBI:25512, GOC:jl]


id: GO:0042137
name: sequestering of neurotransmitter
namespace: biological_process
def:
  "The process of binding or confining a neurotransmitter such that it is separated from other components of a biological system." [GOC:ai]


id: GO:0042138
name: meiotic DNA double-strand break formation
namespace: biological_process
def:
  "The cell cycle process in which double-strand breaks are generated at defined hotspots throughout the genome during meiosis I. This results in the initiation of meiotic recombination." [GOC:elh, GOC:jl, PMID:11529427]


id: GO:0042139
name: early meiotic recombination nodule assembly
namespace: biological_process
def:
  "During meiosis, the aggregation, arrangement and bonding together of strand exchange proteins (recombinases) to form small, electron dense structures in association with meiotic chromosomes during leptotene and zygotene." [GOC:jl, PMID:9334324]


id: GO:0042140
name: late meiotic recombination nodule assembly
namespace: biological_process
def:
  "During meiosis, the aggregation, arrangement and bonding together of strand exchange proteins (recombinases) to form small, electron dense structures in association with meiotic chromosomes during pachytene. Involved in the catalysis crossing over." [GOC:jl, PMID:9334324]


id: GO:0042141
name: obsolete mating pheromone exporter
namespace: molecular_function
def:
  "OBSOLETE. Exports diffusible peptide signals that are responsible for binding to other cells and triggering a series of responses to facilitate mating." [GOC:jl]


id: GO:0042142
name: obsolete heavy metal chelation
namespace: biological_process
def:
  "OBSOLETE. The strong but reversible binding of a heavy metal ion by a larger molecule such as protein." [GOC:jl, ISBN:0124325653]


id: GO:0042147
name: retrograde transport, endosome to Golgi
namespace: biological_process
def:
  "The directed movement of membrane-bounded vesicles from endosomes back to the trans-Golgi network where they are recycled for further rounds of transport." [GOC:jl, PMID:10873832, PMID:16936697]


id: GO:0042148
name: strand invasion
namespace: biological_process
def:
  "The process in which the nucleoprotein complex (composed of the broken single-strand DNA and the recombinase) searches and identifies a region of homology in intact duplex DNA. The broken single-strand DNA displaces the like strand and forms Watson-Crick base pairs with its complement, forming a duplex in which each strand is from one of the two recombining DNA molecules." [GOC:elh, PMID:10357855]


id: GO:0042149
name: cellular response to glucose starvation
namespace: biological_process
def:
  "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of glucose." [GOC:jl]


id: GO:0042150
name: plasmid recombination
namespace: biological_process
def:
  "A process of DNA recombination occurring within a plasmid or between plasmids and other plasmids or DNA molecules." [GOC:mlg]


id: GO:0042151
name: nematocyst
namespace: cellular_component
def:
  "An organelle found in cnidoblast (nematoblast) cells. When matured, these stinging organelles store toxins and can deliver them when the cnidocil (a short extension of the cnidocyst) is stimulated by a prey or another stimulus." [DOI:10.1139/z02-135, GOC:jl]


id: GO:0042152
name: RNA-mediated DNA recombination
namespace: biological_process
def:
  "The reverse transcription of an RNA molecule followed by recombination between the resultant cDNA and its homologous chromosomal allele." [GOC:jl, PMID:8380627]


id: GO:0042153
name: obsolete RPTP-like protein binding
namespace: molecular_function
def:
  "OBSOLETE. Interacting selectively and non-covalently with proteins with similar structure/function to receptor protein tyrosine phosphatases." [GOC:jl]


id: GO:0042157
name: lipoprotein metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving any conjugated, water-soluble protein in which the nonprotein group consists of a lipid or lipids." [ISBN:0198506732]


id: GO:0042158
name: lipoprotein biosynthetic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of any conjugated, water-soluble protein in which the nonprotein group consists of a lipid or lipids." [ISBN:0198506732]


id: GO:0042159
name: lipoprotein catabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the breakdown of any conjugated, water-soluble protein in which the nonprotein group consists of a lipid or lipids." [ISBN:0198506732]


id: GO:0042160
name: lipoprotein modification
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the covalent alteration of one or more amino acid or lipid residues occurring in a lipoprotein, any conjugated, water-soluble protein in which the nonprotein group consists of a lipid or lipids." [GOC:mah]


id: GO:0042161
name: lipoprotein oxidation
namespace: biological_process
def:
  "The modification of a lipoprotein by oxidation of one or more amino acids or the lipid group." [GOC:mah]


id: GO:0042162
name: telomeric DNA binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with a telomere, a specific structure at the end of a linear chromosome required for the integrity and maintenance of the end." [GOC:jl, SO:0000624]


id: GO:0042165
name: neurotransmitter binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with a neurotransmitter, any chemical substance that is capable of transmitting (or inhibiting the transmission of) a nerve impulse from a neuron to another cell." [ISBN:0198506732]


id: GO:0042166
name: acetylcholine binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with acetylcholine, an acetic acid ester of the organic base choline that functions as a neurotransmitter, released at the synapses of parasympathetic nerves and at neuromuscular junctions." [GOC:ai]


id: GO:0042167
name: heme catabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the breakdown of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:jl]


id: GO:0042168
name: heme metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [GOC:jl, ISBN:0124325653]


id: GO:0042169
name: SH2 domain binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with a SH2 domain (Src homology 2) of a protein, a protein domain of about 100 amino-acid residues and belonging to the alpha + beta domain class." [GOC:go_curators, Pfam:PF00017]


id: GO:0042171
name: lysophosphatidic acid acyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the transfer of acyl groups from an acyl-CoA to lysophosphatidic acid to form phosphatidic acid." [GOC:ab, PMID:16369050]


id: GO:0042174
name: negative regulation of sporulation resulting in formation of a cellular spore
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of sporulation." [GOC:go_curators]


id: GO:0042175
name: nuclear outer membrane-endoplasmic reticulum membrane network
namespace: cellular_component
def:
  "The continuous network of membranes encompassing the nuclear outer membrane and the endoplasmic reticulum membrane." [GOC:bf, GOC:jl, GOC:mah, GOC:mcc, GOC:pr, GOC:vw]


id: GO:0042176
name: regulation of protein catabolic process
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds." [GOC:go_curators, GOC:jl]


id: GO:0042177
name: negative regulation of protein catabolic process
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds." [GOC:go_curators, GOC:jl, PMID:10207076]


id: GO:0042178
name: xenobiotic catabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the breakdown of a xenobiotic compound, a compound foreign to living organisms. Used of chemical compounds, e.g. a xenobiotic chemical, such as a pesticide." [GOC:jl]


id: GO:0042179
name: nicotine biosynthetic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of nicotine, (S)(-)-3-(1-methyl-2-pyrrolidinyl)pyridine." [GOC:sm, ISBN:0198547684]


id: GO:0042180
name: cellular ketone metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving any of a class of organic compounds that contain the carbonyl group, CO, and in which the carbonyl group is bonded only to carbon atoms, as carried out by individual cells. The general formula for a ketone is RCOR, where R and R are alkyl or aryl groups." [GOC:jl, ISBN:0787650153]


id: GO:0042181
name: ketone biosynthetic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of ketones, a class of organic compounds that contain the carbonyl group, CO, and in which the carbonyl group is bonded only to carbon atoms. The general formula for a ketone is RCOR, where R and R are alkyl or aryl groups." [GOC:go_curators]


id: GO:0042182
name: ketone catabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the breakdown of ketones, a class of organic compounds that contain the carbonyl group, CO, and in which the carbonyl group is bonded only to carbon atoms. The general formula for a ketone is RCOR, where R and R are alkyl or aryl groups." [GOC:go_curators]


id: GO:0042183
name: formate catabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the breakdown of formate, also known as methanoate, the anion HCOO- derived from methanoic (formic) acid." [ISBN:0198506732]


id: GO:0042184
name: xylene catabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the breakdown of xylene, a mixture of three colorless, aromatic hydrocarbon liquids, ortho-, meta- and para-xylene." [GOC:go_curators]


id: GO:0042185
name: m-xylene catabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the breakdown of m-xylene, 1,3-dimethylbenzene, a colorless, liquid aromatic hydrocarbon." [GOC:go_curators, GOC:jl]


id: GO:0042186
name: o-xylene catabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the breakdown of o-xylene, (1,2-dimethylbenzene) a colorless, liquid aromatic hydrocarbon." [GOC:jl]


id: GO:0042187
name: p-xylene catabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the breakdown of p-xylene (1,4-dimethylbenzene), a colorless, liquid aromatic hydrocarbon." [GOC:jl]


id: GO:0042188
name: 1,1,1-trichloro-2,2-bis-(4-chlorophenyl)ethane catabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the breakdown of 1,1,1-trichloro-2,2-bis-(4-chlorophenyl)ethane (DDT), a chlorinated broad spectrum contact insecticide." [GOC:jl]


id: GO:0042189
name: vanillin biosynthetic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of vanillin, an aromatic hydrocarbon which occurs naturally in black vanilla bean pods." [GOC:jl]


id: GO:0042190
name: vanillin catabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the breakdown of vanillin, an aromatic hydrocarbon which occurs naturally in black vanilla bean pods." [GOC:jl]


id: GO:0042191
name: methylmercury metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving methylmercury (MeHg+), a highly toxic organometal which can accumulate in tissues, particularly in fish species." [GOC:ai]


id: GO:0042192
name: methylmercury biosynthetic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of methylmercury (MeHg+), a highly toxic organometal." [GOC:ai]


id: GO:0042193
name: methylmercury catabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the breakdown of methylmercury (MeHg+), a highly toxic organometal." [GOC:ai]


id: GO:0042194
name: quinate biosynthetic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of quinate, the anion of quinic acid." [GOC:go_curators]


id: GO:0042195
name: aerobic gallate catabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the breakdown of gallate, the anion of gallic acid, in the presence of oxygen." [GOC:jl]


id: GO:0042196
name: chlorinated hydrocarbon metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving chlorinated hydrocarbons, any hydrocarbon with one or more chlorine atoms attached to it." [GOC:ai]


id: GO:0042197
name: halogenated hydrocarbon metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving halogenated hydrocarbons, any hydrocarbon with one or more halogen atoms attached to it. Halogens include fluorine, chlorine, bromine and iodine." [GOC:ai]


id: GO:0042198
name: nylon metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving nylon, a polymer where the main polymer chain comprises recurring amide groups; these compounds are generally formed from combinations of diamines, diacids and amino acids." [UniProtKB-KW:KW-0549]


id: GO:0042199
name: cyanuric acid metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving cyanuric acid, a suspected gastrointestinal or liver toxicant, and a potential degradation product of triazine herbicides, such as atrazine and simazine. It is widely used for the stabilization of available chlorine in swimming pool water and is also the starting compound for the synthesis of many organic derivatives." [UM-BBD_pathwayID:cya]


id: GO:0042200
name: cyanuric acid catabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the breakdown of cyanuric acid, a potential degradation product of triazine herbicides." [UM-BBD_pathwayID:cya]


id: GO:0042201
name: N-cyclopropylmelamine metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving N-cyclopropylmelamine, a triazine compound commonly used as an insect growth regulator insecticide." [UM-BBD_pathwayID:cpm]


id: GO:0042202
name: N-cyclopropylmelamine catabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the breakdown of N-cyclopropylmelamine, a triazine compound commonly used as an insecticide." [UM-BBD_pathwayID:cpm]


id: GO:0042203
name: toluene catabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the breakdown of toluene, a volatile monoaromatic hydrocarbon found in crude petroleum and petroleum products." [GOC:go_curators]


id: GO:0042204
name: s-triazine compound catabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the breakdown of any s-triazine compound. These compounds include many pesticides of widespread use in agriculture, and are characterized by a symmetrical hexameric ring consisting of alternating carbon and nitrogen atoms." [UM-BBD_pathwayID:tria]


id: GO:0042205
name: chlorinated hydrocarbon catabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the breakdown of chlorinated hydrocarbons, any hydrocarbon with one or more chlorine atoms attached to it." [GOC:ai]


id: GO:0042206
name: halogenated hydrocarbon catabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the breakdown of halogenated hydrocarbons, any hydrocarbon with one or more halogen atoms attached to it." [GOC:ai]


id: GO:0042207
name: styrene catabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the breakdown of styrene, an aromatic hydrocarbon liquid used in the manufacture of polystyrene." [GOC:jl]


id: GO:0042208
name: propylene catabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the breakdown of propylene, an alkene produced by catalytic or thermal cracking of hydrocarbons or as a by-product of petroleum refining." [GOC:jl]


id: GO:0042209
name: orcinol catabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the breakdown of orcinol (5-methyl-1,3-benzenediol), an aromatic compound derived from the fermentation of lichen and synthesized by some higher plants." [GOC:jl]


id: GO:0042210
name: octamethylcyclotetrasiloxane catabolic process to dimethylsilanediol
namespace: biological_process
def:
  "The anaerobic chemical reactions and pathways resulting in the breakdown of octamethylcyclotetrasiloxane into dimethylsilanediol. The former is a tetramer of the latter." [GOC:jl]


id: GO:0042211
name: dimethylsilanediol catabolic process
namespace: biological_process
def:
  "The aerobic chemical reactions and pathways resulting in the breakdown of dimethylsilanediol, the smallest member of the dialkylsilanediols. Dimethylsilanediol is the monomer of polydimethylsiloxane, a compound which can be found in a wide range of industrial and consumer products." [GOC:jl]


id: GO:0042212
name: cresol metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving cresol, a mixture of the aromatic alcohol isoforms o-, p-, and m-cresol, which is obtained from coal tar or petroleum. The isomers are used as disinfectants, textile scouring agents, surfactants and as intermediates in the manufacture of salicylaldehyde, coumarin, and herbicides as well as being a major component of creosote." [UM-BBD_pathwayID:mcr]


id: GO:0042213
name: m-cresol catabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the breakdown of m-cresol (3-hydroxytoluene), the meta-isoform of cresol." [GOC:jl]


id: GO:0042214
name: terpene metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving terpenes, any of a large group of hydrocarbons that are made up of isoprene (C5H8) units which may be cyclic, acyclic or multicyclic, saturated or unsaturated, and may contain various functional groups." [CHEBI:35186, GOC:curators]


id: GO:0042215
name: anaerobic phenol-containing compound metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving a phenol, any compound containing one or more hydroxyl groups directly attached to an aromatic carbon ring, in the absence of oxygen." [CHEBI:33853, ISBN:0198506732]


id: GO:0042216
name: phenanthrene catabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the breakdown of phenanthrene, a tricyclic aromatic hydrocarbon." [GOC:jl]


id: GO:0042217
name: 1-aminocyclopropane-1-carboxylate catabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the breakdown of 1-aminocyclopropane-1-carboxylate, a natural product found in plant tissues. It is a key intermediate in the biosynthesis of ethylene (ethene), a fruit-ripening hormone in plants." [GOC:go_curators]


id: GO:0042218
name: 1-aminocyclopropane-1-carboxylate biosynthetic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of 1-aminocyclopropane-1-carboxylate, a natural product found in plant tissues. It is a key intermediate in the biosynthesis of ethylene (ethene), a fruit-ripening hormone in plants." [GOC:go_curators]


id: GO:0042219
name: cellular modified amino acid catabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the breakdown of compounds derived from amino acids, organic acids containing one or more amino substituents." [GOC:ai]


id: GO:0042220
name: response to cocaine
namespace: biological_process
def:
  "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cocaine stimulus. Cocaine is a crystalline alkaloid obtained from the leaves of the coca plant." [CHEBI:27958, GOC:ef, GOC:jl]


id: GO:0042221
name: response to chemical
namespace: biological_process
def:
  "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemical stimulus." [GOC:jl]


id: GO:0042222
name: interleukin-1 biosynthetic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of interleukin-1, an interleukin produced mainly by activated macrophages. It is involved in the inflammatory response, and is identified as an endogenous pyrogen." [GOC:jl, ISBN:0198506732]


id: GO:0042223
name: interleukin-3 biosynthetic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of interleukin-3." [GOC:go_curators]


id: GO:0042225
name: interleukin-5 biosynthetic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of interleukin-5." [GOC:go_curators]


id: GO:0042226
name: interleukin-6 biosynthetic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of interleukin-6." [GOC:go_curators]


id: GO:0042227
name: interleukin-7 biosynthetic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of interleukin-7." [GOC:go_curators]


id: GO:0042228
name: interleukin-8 biosynthetic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of interleukin-8." [GOC:go_curators]


id: GO:0042229
name: interleukin-9 biosynthetic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of interleukin-9." [GOC:go_curators]


id: GO:0042230
name: interleukin-11 biosynthetic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of interleukin-11." [GOC:go_curators]


id: GO:0042231
name: interleukin-13 biosynthetic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of interleukin-13." [GOC:go_curators]


id: GO:0042232
name: interleukin-14 biosynthetic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of interleukin-14." [GOC:go_curators]


id: GO:0042233
name: interleukin-15 biosynthetic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of interleukin-15." [GOC:go_curators]


id: GO:0042234
name: interleukin-16 biosynthetic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of interleukin-16." [GOC:go_curators]


id: GO:0042235
name: interleukin-17 biosynthetic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of any member of the interleukin-17 family of cytokines." [GOC:add, GOC:go_curators]


id: GO:0042236
name: interleukin-19 biosynthetic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of interleukin-19." [GOC:go_curators]


id: GO:0042237
name: interleukin-20 biosynthetic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of interleukin-20." [GOC:go_curators]


id: GO:0042238
name: interleukin-21 biosynthetic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of interleukin-21." [GOC:go_curators]


id: GO:0042239
name: interleukin-22 biosynthetic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of interleukin-22." [GOC:go_curators]


id: GO:0042240
name: interleukin-23 biosynthetic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of interleukin-23." [GOC:go_curators]


id: GO:0042241
name: interleukin-18 biosynthetic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of interleukin-18." [GOC:go_curators]


id: GO:0042242
name: cobyrinic acid a,c-diamide synthase activity
namespace: molecular_function
def:
  "Catalysis of the conversion of cobyrinic acid to cobyrinic acid a,c-diamide via the intermediate formation of cobyrinic acid c-monoamide." [PMID:2172209]


id: GO:0042243
name: asexual spore wall assembly
namespace: biological_process
def:
  "The aggregation, arrangement and bonding together of a set of components to form an asexual spore wall, the specialized envelope lying outside the cell membrane of a spore derived from an asexual process. Examples of this process are found in Bacterial and Fungal species." [GOC:mah]


id: GO:0042244
name: spore wall assembly
namespace: biological_process
def:
  "The aggregation, arrangement and bonding together of a set of components to form a spore wall; a spore wall is the specialized envelope lying outside the cell membrane of a spore." [GOC:mah, GOC:pg]


id: GO:0042245
name: RNA repair
namespace: biological_process
def:
  "Any process that results in the repair of damaged RNA." [PMID:11000254, PMID:11070075, UniProtKB-KW:KW-0692]


id: GO:0042247
name: establishment of planar polarity of follicular epithelium
namespace: biological_process
def:
  "Coordinated organization of groups of cells in the plane of a follicular epithelium, such that they all orient to similar coordinates." [GOC:ascb_2009, GOC:bf, GOC:dph, GOC:tb]


id: GO:0042249
name: establishment of planar polarity of embryonic epithelium
namespace: biological_process
def:
  "Coordinated organization of groups of cells in the plane of an embryonic epithelium, such that they all orient to similar coordinates." [GOC:ascb_2009, GOC:dph, GOC:jl, GOC:tb]


id: GO:0042252
name: establishment of planar polarity of larval imaginal disc epithelium
namespace: biological_process
def:
  "Coordinated organization of groups of cells in the plane of a larval imaginal disc epithelium, such that they all orient to similar coordinates." [GOC:jl]


id: GO:0042253
name: granulocyte macrophage colony-stimulating factor biosynthetic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of granulocyte macrophage colony-stimulating factor, cytokines that act in hemopoiesis by controlling the production, differentiation, and function of two related white cell populations, granulocytes and monocytes-macrophages." [GOC:jl, ISBN:0198506732]


id: GO:0042254
name: ribosome biogenesis
namespace: biological_process
def:
  "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits; includes transport to the sites of protein synthesis." [GOC:ma]


id: GO:0042255
name: ribosome assembly
namespace: biological_process
def:
  "The aggregation, arrangement and bonding together of the mature ribosome and of its subunits." [GOC:ma]


id: GO:0042256
name: mature ribosome assembly
namespace: biological_process
def:
  "The aggregation, arrangement and bonding together of the large and small ribosomal subunits into a functional ribosome." [GOC:ma]


id: GO:0042258
name: molybdenum incorporation via L-serinyl molybdopterin guanine dinucleotide
namespace: biological_process
def:
  "The incorporation of molybdenum into a protein via L-serinyl molybdopterin guanine dinucleotide." [PDB:1EU1, PMID:8658132, RESID:AA0319]


id: GO:0042259
name: peptidyl-L-beta-methylthioasparagine biosynthetic process from peptidyl-asparagine
namespace: biological_process
def:
  "The modification of peptidyl-asparagine to form peptidyl-L-beta-methylthioasparagine, typical of bacterial ribosomal protein S12." [GOC:jsg, RESID:AA0320]


id: GO:0042263
name: neuropeptide F receptor activity
namespace: molecular_function
def:
  "Combining with neuropeptide F and transmitting the signal within the cell to initiate a change in cell activity. Neuropeptide F is an arthropod peptide of more than 28 residues (typically 28-45) with a consensus C-terminal RxRFamide (commonly RPRFa, but also RVRFa." [GOC:bf, GOC:ma, PMID:21440021]


id: GO:0042267
name: natural killer cell mediated cytotoxicity
namespace: biological_process
def:
  "The directed killing of a target cell by a natural killer cell through the release of granules containing cytotoxic mediators or through the engagement of death receptors." [GOC:add, GOC:pr]


id: GO:0042268
name: regulation of cytolysis
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of the rupture of cell membranes and the loss of cytoplasm." [GOC:jl]


id: GO:0042269
name: regulation of natural killer cell mediated cytotoxicity
namespace: biological_process
def:
  "Any process that modulates the frequency, rate, or extent of natural killer cell mediated cytotoxicity." [GOC:add, ISBN:0781735149]


id: GO:0042270
name: protection from natural killer cell mediated cytotoxicity
namespace: biological_process
def:
  "The process of protecting a cell from natural killer cell mediated cytotoxicity." [GOC:add, ISBN:0781735149]


id: GO:0042271
name: susceptibility to natural killer cell mediated cytotoxicity
namespace: biological_process
def:
  "The process of causing a cell to become susceptible to natural killer cell mediated cytotoxicity." [GOC:add, ISBN:0781735149]


id: GO:0042272
name: nuclear RNA export factor complex
namespace: cellular_component
def:
  "A protein complex that contains two proteins (know in several organisms, including Drosophila, as NXF1 and NXF2) and is required for the export of the majority of mRNAs from the nucleus to the cytoplasm; localized in the nucleoplasm and at both the nucleoplasmic and cytoplasmic faces of the nuclear pore complex; shuttles between the nucleus and the cytoplasm." [PMID:11780633]


id: GO:0042273
name: ribosomal large subunit biogenesis
namespace: biological_process
def:
  "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a large ribosomal subunit; includes transport to the sites of protein synthesis." [GOC:jl]


id: GO:0042274
name: ribosomal small subunit biogenesis
namespace: biological_process
def:
  "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a small ribosomal subunit; includes transport to the sites of protein synthesis." [GOC:jl]


id: GO:0042275
name: error-free postreplication DNA repair
namespace: biological_process
def:
  "The conversion of DNA-damage induced single-stranded gaps into large molecular weight DNA via processes such as template switching, which does not remove the replication-blocking lesions but does not increase the endogenous mutation rate." [GOC:elh, GOC:jl, PMID:11459630]


id: GO:0042276
name: error-prone translesion synthesis
namespace: biological_process
def:
  "The conversion of DNA-damage induced single-stranded gaps into large molecular weight DNA after replication by using a specialized DNA polymerase or replication complex to insert a defined nucleotide across the lesion. This process does not remove the replication-blocking lesions and causes an increase in the endogenous mutation level. For example, in E. coli, a low fidelity DNA polymerase, pol V, copies lesions that block replication fork progress. This produces mutations specifically targeted to DNA template damage sites, but it can also produce mutations at undamaged sites." [GOC:elh, GOC:jl, PMID:11485998]


id: GO:0042277
name: peptide binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with peptides, any of a group of organic compounds comprising two or more amino acids linked by peptide bonds." [GOC:jl]


id: GO:0042278
name: purine nucleoside metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving one of a family of organic molecules consisting of a purine base covalently bonded to a sugar ribose (a ribonucleoside) or deoxyribose (a deoxyribonucleoside)." [GOC:jl, ISBN:0140512713]


id: GO:0042279
name: nitrite reductase (cytochrome, ammonia-forming) activity
namespace: molecular_function
def:
  "Catalysis of the reaction: NH3 + 2 H2O + 6 ferricytochrome c = nitrite + 6 ferrocytochrome c + 7 H+." [EC:1.7.2.2]


id: GO:0042280
name: obsolete cell surface antigen activity, host-interacting
namespace: molecular_function
def:
  "OBSOLETE. Functions as an immunogenic target for the host immune system that masks other invariant surface molecules from immune recognition." [GOC:mb]


id: GO:0042281
name: dolichyl pyrophosphate Man9GlcNAc2 alpha-1,3-glucosyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the addition of the first glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation; the transfer of glucose from dolichyl phosphate glucose (Dol-P-Glc) on to the lipid-linked oligosaccharide Man(9)GlcNAc(2)-PP-Dol." [GOC:al, MetaCyc:RXN-5470]


id: GO:0042282
name: hydroxymethylglutaryl-CoA reductase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: (R)-mevalonate + CoA + 2 NAD(+) = (S)-3-hydroxy-3-methylglutaryl-CoA + 2 H(+) + 2 NADH." [EC:1.1.1.88, RHEA:14836]


id: GO:0042283
name: dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the addition of the second glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation; the transfer of glucose from dolichyl phosphate glucose (Dol-P-Glc) on to the lipid-linked oligosaccharide Glc(1)Man(9)GlcNAc(2)-PP-Dol." [MetaCyc:RXN-5471, PMID:12480927]


id: GO:0042284
name: sphingolipid delta-4 desaturase activity
namespace: molecular_function
def:
  "Catalysis of the introduction of a trans double bond between C4 and C5 of the long chain base region of a sphingolipid. Sphingolipids are composed of a long chain base (LCB) amide-linked to a very long chain fatty acid." [PMID:12417141]


id: GO:0042285
name: xylosyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the transfer of a xylosyl group to an acceptor molecule, typically another carbohydrate or a lipid." [GOC:ai]


id: GO:0042286
name: glutamate-1-semialdehyde 2,1-aminomutase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: (S)-4-amino-5-oxopentanoate = 5-aminolevulinate." [EC:5.4.3.8, RHEA:14268]


id: GO:0042287
name: MHC protein binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with major histocompatibility complex molecules; a set of molecules displayed on cell surfaces that are responsible for lymphocyte recognition and antigen presentation." [GOC:jl]


id: GO:0042288
name: MHC class I protein binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with major histocompatibility complex class I molecules; a set of molecules displayed on cell surfaces that are responsible for lymphocyte recognition and antigen presentation." [GOC:jl]


id: GO:0042289
name: MHC class II protein binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with major histocompatibility complex class II molecules; a set of molecules displayed on cell surfaces that are responsible for lymphocyte recognition and antigen presentation." [GOC:jl]


id: GO:0042292
name: URM1 activating enzyme activity
namespace: molecular_function
def:
  "Catalysis of the activation of the small ubiquitin-related modifier URM1, through the formation of an ATP-dependent high-energy thiolester bond." [GOC:mah]


id: GO:0042293
name: Hub1 activating enzyme activity
namespace: molecular_function
def:
  "Catalysis of the activation of the small ubiquitin-related modifier Hub1, through the formation of an ATP-dependent high-energy thiolester bond." [GOC:mah]


id: GO:0042294
name: URM1 transferase activity
namespace: molecular_function
def:
  "Catalysis of the transfer of URM1 from one protein to another via the reaction X-URM1 + Y --> Y-URM1 + X, where both X-URM1 and Y-URM1 are covalent linkages." [GOC:mah, PMID:12826404]


id: GO:0042296
name: ISG15 transferase activity
namespace: molecular_function
def:
  "Catalysis of the transfer of ISG15 from one protein to another via the reaction X-ISG15 + Y --> Y-ISG15 + X, where both X-ISG15 and Y-ISG15 are covalent linkages." [GOC:mah, PMID:12826404]


id: GO:0042297
name: vocal learning
namespace: biological_process
def:
  "A behavioral process whose outcome is a relatively long-lasting behavioral change whereby an organism modifies innate vocalizations to imitate sounds produced by others." [GOC:BHF, GOC:dos, GOC:rl, PMID:16418265, PMID:17035521]


