# go

id: GO:0048709
name: oligodendrocyte differentiation
namespace: biological_process
def:
  "The process in which a relatively unspecialized cell acquires the specialized features of an oligodendrocyte. An oligodendrocyte is a type of glial cell involved in myelinating the axons of neurons in the central nervous system." [GOC:vp, PMID:15139015]


id: GO:0048710
name: regulation of astrocyte differentiation
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of astrocyte differentiation." [GOC:vp, PMID:15139015]


id: GO:0048711
name: positive regulation of astrocyte differentiation
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of astrocyte differentiation." [GOC:vp, PMID:15139015]


id: GO:0048712
name: negative regulation of astrocyte differentiation
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of astrocyte differentiation." [GOC:vp, PMID:15139015]


id: GO:0048713
name: regulation of oligodendrocyte differentiation
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of oligodendrocyte differentiation." [GOC:vp, PMID:15139015]


id: GO:0048714
name: positive regulation of oligodendrocyte differentiation
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of oligodendrocyte differentiation." [GOC:vp, PMID:15139015]


id: GO:0048715
name: negative regulation of oligodendrocyte differentiation
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of oligodendrocyte differentiation." [GOC:vp, PMID:15139015]


id: GO:0048717
name: anterior cibarial plate morphogenesis
namespace: biological_process
def:
  "The process in which the anatomical structures of the anterior cibarial plate are generated and organized." [GOC:rc]


id: GO:0048718
name: cibarial fish-trap bristle morphogenesis
namespace: biological_process
def:
  "The process in which the anatomical structures of a cibarial fish-trap bristle are generated and organized. A cibarial fish-trap bristle is a sensory bristle on the anterior plate of the cibarium." [FBbt:00004136, GOC:rc]


id: GO:0048719
name: epistomal sclerite morphogenesis
namespace: biological_process
def:
  "The process in which the anatomical structures of the epistomal sclerite are generated and organized." [GOC:rc]


id: GO:0048720
name: posterior cibarial plate morphogenesis
namespace: biological_process
def:
  "The process in which the anatomical structures of the posterior cibarial plate are generated and organized." [GOC:rc]


id: GO:0048721
name: clypeus morphogenesis
namespace: biological_process
def:
  "The process in which the anatomical structures of the clypeus are generated and organized." [GOC:rc]


id: GO:0048722
name: anterior cibarial plate development
namespace: biological_process
def:
  "The process whose specific outcome is the progression of the anterior cibarial plate over time, from their formation to the mature structure." [GOC:rc]


id: GO:0048723
name: clypeus development
namespace: biological_process
def:
  "The process whose specific outcome is the progression of the clypeus over time, from its formation to the mature structure. The clypeus is the shield-shaped plate on an insect's head." [GOC:rc]


id: GO:0048724
name: epistomal sclerite development
namespace: biological_process
def:
  "The process whose specific outcome is the progression of the epistomal sclerite over time, from its formation to the mature structure." [GOC:rc]


id: GO:0048725
name: cibarial fish-trap bristle development
namespace: biological_process
def:
  "The process whose specific outcome is the progression of the cibarial fish-trap bristle over time, from its formation to the mature structure. A cibarial fish-trap bristle is a sensory bristle on the anterior plate of the cibarium." [FBbt:00004136, GOC:rc]


id: GO:0048726
name: labrum development
namespace: biological_process
def:
  "The process whose specific outcome is the progression of the labrum over time, from its formation to the mature structure." [GOC:rc]


id: GO:0048727
name: posterior cibarial plate development
namespace: biological_process
def:
  "The process whose specific outcome is the progression of the posterior cibarial plate over time, from its formation to the mature structure." [GOC:rc]


id: GO:0048728
name: proboscis development
namespace: biological_process
def:
  "The process whose specific outcome is the progression of the proboscis over time, from its formation to the mature structure." [GOC:rc]


id: GO:0048729
name: tissue morphogenesis
namespace: biological_process
def:
  "The process in which the anatomical structures of a tissue are generated and organized." [GOC:dph, GOC:jid]


id: GO:0048730
name: epidermis morphogenesis
namespace: biological_process
def:
  "The process in which the anatomical structures of the epidermis are generated and organized. The epidermis is the outer epithelial layer of an animal, it may be a single layer that produces an extracellular material (e.g. the cuticle of arthropods) or a complex stratified squamous epithelium, as in the case of many vertebrate species." [GOC:jid, UBERON:0001003]


id: GO:0048731
name: system development
namespace: biological_process
def:
  "The process whose specific outcome is the progression of an organismal system over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process." [GOC:dph, GOC:jid]


id: GO:0048732
name: gland development
namespace: biological_process
def:
  "The process whose specific outcome is the progression of a gland over time, from its formation to the mature structure. A gland is an organ specialised for secretion." [GOC:jid]


id: GO:0048733
name: sebaceous gland development
namespace: biological_process
def:
  "The process whose specific outcome is the progression of the sebaceous gland over time, from its formation to the mature structure." [GOC:jid]


id: GO:0048734
name: proboscis morphogenesis
namespace: biological_process
def:
  "The process in which the anatomical structures of the proboscis are generated and organized. The proboscis is the trunk-like extension of the mouthparts on the adult head." [GOC:jid, GOC:rc]


id: GO:0048735
name: haltere morphogenesis
namespace: biological_process
def:
  "The process in which the anatomical structures of a haltere are generated and organized." [GOC:jid, GOC:rc]


id: GO:0048736
name: appendage development
namespace: biological_process
def:
  "The process whose specific outcome is the progression of an appendage over time, from its formation to the mature structure. An appendage is an organ or part that is attached to the trunk of an organism, such as a limb or a branch." [GOC:jid, GOC:rc]


id: GO:0048737
name: imaginal disc-derived appendage development
namespace: biological_process
def:
  "The process whose specific outcome is the progression of an appendage over time, from its formation in the imaginal disc to the mature structure. An appendage is an organ or part that is attached to the trunk of an organism." [GOC:jid, GOC:mtg_sensu, GOC:rc]


id: GO:0048738
name: cardiac muscle tissue development
namespace: biological_process
def:
  "The process whose specific outcome is the progression of cardiac muscle over time, from its formation to the mature structure." [GOC:dph, GOC:jid, GOC:lm]


id: GO:0048739
name: cardiac muscle fiber development
namespace: biological_process
def:
  "The process whose specific outcome is the progression of cardiac muscle fiber over time, from its formation to the mature structure." [GOC:dph, GOC:jid, GOC:lm]


id: GO:0048740
name: obsolete striated muscle fiber development
namespace: biological_process
def:
  "OBSOLETE. The process whose specific outcome is the amplification and progression of myoblasts (muscle precursor cells) into terminally differentiated multinucleated muscle fibers." [GOC:dph, GOC:jid, GOC:lm, GOC:mtg_muscle]


id: GO:0048741
name: skeletal muscle fiber development
namespace: biological_process
def:
  "The process whose specific outcome is the progression of the skeletal muscle fiber over time, from its formation to the mature structure. Muscle fibers are formed by the maturation of myotubes. They can be classed as slow, intermediate/fast or fast." [GOC:dph, GOC:ef, GOC:jid, GOC:lm, GOC:mtg_muscle]


id: GO:0048742
name: regulation of skeletal muscle fiber development
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of skeletal muscle fiber development. Muscle fibers are formed by the maturation of myotubes. They can be classed as slow, intermediate/fast or fast." [GOC:dph, GOC:jid, GOC:mtg_muscle, GOC:sm]


id: GO:0048743
name: positive regulation of skeletal muscle fiber development
namespace: biological_process
def:
  "Any process that activates, maintains or increases the rate of skeletal muscle fiber development. Muscle fibers are formed by the maturation of myotubes. They can be classed as slow, intermediate/fast or fast." [GOC:dph, GOC:jid, GOC:lm, GOC:mtg_muscle]


id: GO:0048744
name: negative regulation of skeletal muscle fiber development
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of skeletal muscle fiber development. Muscle fibers are formed by the maturation of myotubes. They can be classed as slow, intermediate/fast or fast." [GOC:dph, GOC:jid, GOC:lm, GOC:mtg_muscle]


id: GO:0048745
name: smooth muscle tissue development
namespace: biological_process
def:
  "The process whose specific outcome is the progression of smooth muscle over time, from its formation to the mature structure." [GOC:dph, GOC:jid, GOC:lm]


id: GO:0048746
name: obsolete smooth muscle fiber development
namespace: biological_process
def:
  "OBSOLETE. The process whose specific outcome is the progression of smooth muscle fiber over time, from its formation to the mature structure." [GOC:dph, GOC:jid, GOC:lm, GOC:mtg_muscle]


id: GO:0048747
name: muscle fiber development
namespace: biological_process
def:
  "The process whose specific outcome is the progression of the muscle fiber over time, from its formation to the mature structure. In skeletal muscle, fibers are formed by the maturation of myotubes. They can be classed as slow, intermediate/fast or fast." [GOC:dph, GOC:jid, GOC:lm, GOC:mtg_muscle]


id: GO:0048749
name: compound eye development
namespace: biological_process
def:
  "The process whose specific outcome is the progression of the compound eye over time, from its formation to the mature structure. The compound eye is an organ of sight that contains multiple repeating units, often arranged hexagonally. Each unit has its own lens and photoreceptor cell(s) and can generate either a single pixelated image or multiple images, per eye." [GOC:jid, GOC:mtg_sensu, Wikipedia:Eye]


id: GO:0048750
name: compound eye corneal lens morphogenesis
namespace: biological_process
def:
  "The process in which the anatomical structures of the compound eye corneal lens are generated and organized." [GOC:jid]


id: GO:0048752
name: semicircular canal morphogenesis
namespace: biological_process
def:
  "The process in which the anatomical structures of the semicircular canals are generated and organized." [GOC:dgh, GOC:dph, GOC:jid]


id: GO:0048753
name: pigment granule organization
namespace: biological_process
def:
  "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a pigment granule." [GOC:rc]


id: GO:0048754
name: branching morphogenesis of an epithelial tube
namespace: biological_process
def:
  "The process in which the anatomical structures of branches in an epithelial tube are generated and organized. A tube is a long hollow cylinder." [GOC:dgh, GOC:dph, GOC:jid]


id: GO:0048755
name: branching morphogenesis of a nerve
namespace: biological_process
def:
  "The process in which the anatomical structures of branches in a nerve are generated and organized. This term refers to an anatomical structure (nerve) not a cell (neuron)." [GOC:dgh, GOC:dph, GOC:jid]


id: GO:0048756
name: sieve cell differentiation
namespace: biological_process
def:
  "The process in which a relatively unspecialized cell acquires specialized features of a sieve cell. A sieve cell is a type of sieve element that has relatively undifferentiated sieve areas (with narrow pores). The sieve areas are rather uniform in structure on all walls; that is, there are no sieve plates. Typical of gymnosperms and lower vascular plants. The sieve element is the cell in the phloem tissue concerned with mainly longitudinal conduction of food materials." [GOC:jid, PO:0025415, POC:curators]


id: GO:0048757
name: pigment granule maturation
namespace: biological_process
def:
  "Steps required to form a membrane-bounded organelle into a pigment granule containing pigment. Maturation is a developmental process, independent of morphogenetic (shape) change, that is required for a cell or structure to attain its fully functional state." [GOC:dgh, GOC:jid, GOC:mh]


id: GO:0048758
name: companion cell differentiation
namespace: biological_process
def:
  "The process in which a relatively unspecialized cell acquires specialized features of a companion cell. The companion cell is the specialized parenchyma cell associated with a sieve-tube member in angiosperm phloem and arising from the same mother cell as the sieve-tube member." [CL:0000284, GOC:jid]


id: GO:0048759
name: xylem vessel member cell differentiation
namespace: biological_process
def:
  "The process in which a relatively unspecialized cell acquires specialized features of a vessel member cell. A vessel member cell is one of the components of a vessel in the xylem. It is a dead cell with the wall between adjacent members being variously perforated and the walls that persist variously thickened." [GOC:jid, PO:0002003]


id: GO:0048760
name: plant parenchymal cell differentiation
namespace: biological_process
def:
  "The process in which a relatively unspecialized cell acquires specialized features of a parenchymal cell. Parenchymal cells are the most abundant and versatile cells in plants. They have very few distinguishing characteristics and botanists classify them as any cell type that cannot be assigned to any other structural or functional class. They can redifferentiate and dedifferentiate and are involved in storage, basic metabolism and other processes. The cells are polyhedral, typically with thin, non-lignified cellulose cell walls and nucleate living protoplasm. They vary in size, form, and wall structure." [CL:0000668, GOC:jid, ISBN:069716957X, PO:0005421]


id: GO:0048761
name: collenchyma cell differentiation
namespace: biological_process
def:
  "The process in which a relatively unspecialized cell acquires specialized features of a collenchyma cell. This is a plant cell in which the primary cell walls are unevenly thickened, with most thickening occurring at the cell corners. Cells are living and able to grow, they are elongated, and lignin and secondary walls absent. Collenchyma cells make up collenchyma tissue which acts as a supporting tissue in growing shoots, leaves and petioles. This tissue is often arranged in cortical ribs, as seen prominently in celery and rhubarb petioles." [CL:0000330, GOC:jid, PO:0000075]


id: GO:0048762
name: mesenchymal cell differentiation
namespace: biological_process
def:
  "The process in which a relatively unspecialized cell acquires specialized features of a mesenchymal cell. A mesenchymal cell is a loosely associated cell that is part of the connective tissue in an organism. Mesenchymal cells give rise to more mature connective tissue cell types." [GOC:dph, GOC:jid]


id: GO:0048763
name: calcium-induced calcium release activity
namespace: molecular_function
def:
  "Release of calcium ions from an intracellular vesicle on induction by increased calcium concentration." [GOC:jid, GOC:nln, PMID:2990997, PMID:8381210, PMID:8653752]


id: GO:0048764
name: trichoblast maturation
namespace: biological_process
def:
  "A developmental process, independent of morphogenetic (shape) change, that is required for a trichoblast cell to attain its fully functional state." [GOC:jid]


id: GO:0048765
name: root hair cell differentiation
namespace: biological_process
def:
  "The process in which a relatively unspecialized cell acquires specialized features of a root hair cell." [GOC:jid]


id: GO:0048766
name: root hair initiation
namespace: biological_process
def:
  "The process in which a protrusion or bulge is formed at the site of plant root hair outgrowth." [GOC:jid, PMID:12468740]


id: GO:0048768
name: root hair cell tip growth
namespace: biological_process
def:
  "Localized growth of a plant root hair tip by extension of the cell wall." [GOC:jid, GOC:ki, PMID:12468740]


id: GO:0048769
name: sarcomerogenesis
namespace: biological_process
def:
  "The process in which sarcomeres are added in series within a fiber." [GOC:jid, GOC:lm, PMID:15947030]


id: GO:0048770
name: pigment granule
namespace: cellular_component
def:
  "A small, subcellular membrane-bounded vesicle containing pigment and/or pigment precursor molecules. Pigment granule biogenesis is poorly understood, as pigment granules are derived from multiple sources including the endoplasmic reticulum, coated vesicles, lysosomes, and endosomes." [GOC:jid, GOC:mh]


id: GO:0048771
name: tissue remodeling
namespace: biological_process
def:
  "The reorganization or renovation of existing tissues. This process can either change the characteristics of a tissue such as in blood vessel remodeling, or result in the dynamic equilibrium of a tissue such as in bone remodeling." [GOC:ebc]


id: GO:0048772
name: leucophore differentiation
namespace: biological_process
def:
  "The process in which a relatively unspecialized cell acquires the specialized features of a leucophore cell. Leucophores are pigment cells derived from the neural crest. They contain uric acid or other purine crystals, deposited in stacks called leucosomes. This gives them a white appearance." [GOC:jid, GOC:mh]


id: GO:0048773
name: erythrophore differentiation
namespace: biological_process
def:
  "The process in which a relatively unspecialized cell acquires the specialized features of an erythrophore cell. Erythrophores are pigment cells derived from the neural crest. They contain pteridine and/or carotenoid pigments in structures called pterinosomes or erythrosomes. This gives them an orange to red appearance." [GOC:jid, GOC:mh]


id: GO:0048774
name: cyanophore differentiation
namespace: biological_process
def:
  "The process in which a relatively unspecialized cell acquires the specialized features of a cyanophore cell. Cyanophores are pigment cells derived from the neural crest. They contain a blue pigment of unknown chemical composition. The pigment is stored in fibrous organelles termed cyanosomes." [GOC:jid, GOC:mh]


id: GO:0048776
name: negative regulation of leucophore differentiation
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of leucophore differentiation." [GOC:mh]


id: GO:0048777
name: positive regulation of leucophore differentiation
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of leucophore differentiation." [GOC:mh]


id: GO:0048778
name: regulation of erythrophore differentiation
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of erythrophore differentiation." [GOC:mh]


id: GO:0048779
name: negative regulation of erythrophore differentiation
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of erythrophore differentiation." [GOC:mh]


id: GO:0048780
name: positive regulation of erythrophore differentiation
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of erythrophore differentiation." [GOC:mh]


id: GO:0048782
name: negative regulation of cyanophore differentiation
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of cyanophore differentiation." [GOC:mh]


id: GO:0048783
name: positive regulation of cyanophore differentiation
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of cyanophore differentiation." [GOC:mh]


id: GO:0048784
name: pigment biosynthetic process involved in pigment granule maturation
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of a pigment, contributing to the process in which a membrane-bounded organelle develops into a pigment granule. Maturation is a developmental process, independent of morphogenetic (shape) change, that is required for a cell or structure to attain its fully functional state." [GOC:jid]


id: GO:0048785
name: hatching gland development
namespace: biological_process
def:
  "The process whose specific outcome is the progression of the hatching gland over time, from its formation to the mature structure. The cells of the hatching gland contain enzymes responsible for solubilization of the egg chorion, facilitating the hatching process." [GOC:bf, GOC:dh, GOC:jid]


id: GO:0048786
name: presynaptic active zone
namespace: cellular_component
def:
  "A specialized region of the plasma membrane and cell cortex of a presynaptic neuron; encompasses a region of the plasma membrane where synaptic vesicles dock and fuse, and a specialized cortical cytoskeletal matrix." [GOC:dh, GOC:dl, GOC:ef, GOC:jid, GOC:pr, PMID:3152289]


id: GO:0048787
name: presynaptic active zone membrane
namespace: cellular_component
def:
  "The membrane portion of the presynaptic active zone; it is the site where docking and fusion of synaptic vesicles occurs for the release of neurotransmitters." [PMID:12812759, PMID:12923177, PMID:3152289]


id: GO:0048788
name: cytoskeleton of presynaptic active zone
namespace: cellular_component
def:
  "The specialized cytoskeletal matrix of the presynaptic active zone. It has specialized functions in organizing synaptic events such as immobilisation or translocation of synaptic vesicles, and assembling active zone components. It is believed to form a molecular scaffold that organizes neurotransmitter release sites." [GOC:dh, GOC:dl, GOC:ef, GOC:jid, NIF_Subcellular:sao1470121605, PMID:10944438]


id: GO:0048789
name: cytoskeletal matrix organization at active zone
namespace: biological_process
def:
  "The assembly and arrangement of cytomatrix proteins to form complexes in the cell cortex beneath the active zone, i.e. just beneath the presynaptic plasma membrane." [GOC:dh, GOC:ef, GOC:jid, PMID:12812759]


id: GO:0048790
name: maintenance of presynaptic active zone structure
namespace: biological_process
def:
  "A process which maintains the organization and the arrangement of proteins at the active zone to ensure the fusion and docking of vesicles and the release of neurotransmitters." [GOC:curators, GOC:dph, GOC:pr]


id: GO:0048791
name: calcium ion-regulated exocytosis of neurotransmitter
namespace: biological_process
def:
  "The release of a neurotransmitter into the synaptic cleft by exocytosis of synaptic vesicles, where the release step is dependent on a rise in cytosolic calcium ion levels. " [GOC:curators]


id: GO:0048792
name: spontaneous exocytosis of neurotransmitter
namespace: biological_process
def:
  "The release of a neurotransmitter into the synaptic cleft, where the release step is independent of the presence of calcium ions (Ca2+). The neurotransmitter is contained within a membrane-bounded vesicle, and is released by fusion of the vesicle with the presynaptic plasma membrane of a nerve cell." [GOC:curators]


id: GO:0048793
name: pronephros development
namespace: biological_process
def:
  "The process whose specific outcome is the progression of the pronephros over time, from its formation to the mature structure. In mammals, the pronephros is the first of the three embryonic kidneys to be established and exists only transiently. In lower vertebrates such as fish and amphibia, the pronephros is the fully functional embryonic kidney and is indispensable for larval life." [GOC:bf, GOC:mtg_kidney_jan10, PMID:10535314, PMID:15968585, PMID:18322540, XAO:00002000, ZFA:0000151]


id: GO:0048794
name: swim bladder development
namespace: biological_process
def:
  "The process whose specific outcome is the progression of the swim bladder over time, from its formation to the mature structure. The swim bladder is used by some fishes to maintain buoyancy and may function in addition as a sound producing organ, a sound receptor, and a respiratory organ." [GOC:mh]


id: GO:0048795
name: swim bladder morphogenesis
namespace: biological_process
def:
  "The process in which the anatomical structure of the swim bladder is generated and organized. The swim bladder is used by some fishes to maintain buoyancy and may function in addition as a sound producing organ, a sound receptor, and a respiratory organ." [GOC:mh]


id: GO:0048796
name: swim bladder maturation
namespace: biological_process
def:
  "A developmental process, independent of morphogenetic (shape) change, that is required for a swim bladder to attain its fully functional state. The swim bladder is used by some fishes to maintain buoyancy and may function in addition as a sound producing organ, a sound receptor, and a respiratory organ." [GOC:devbiol]


id: GO:0048797
name: swim bladder formation
namespace: biological_process
def:
  "The process that gives rise to the swim bladder. This process pertains to the initial formation of a structure from unspecified parts. The swim bladder is used by some fishes to maintain buoyancy and may function in addition as a sound producing organ, a sound receptor, and a respiratory organ." [GOC:mh]


id: GO:0048798
name: swim bladder inflation
namespace: biological_process
def:
  "The expansion of the swim bladder by trapped gases. The swim bladder is used by some fishes to maintain buoyancy and may function in addition as a sound producing organ, a sound receptor, and a respiratory organ." [GOC:mh]


id: GO:0048799
name: organ maturation
namespace: biological_process
def:
  "A developmental process, independent of morphogenetic (shape) change, that is required for an organ to attain its fully functional state. An organ is a tissue or set of tissues that work together to perform a specific function or functions." [GOC:curators]


id: GO:0048800
name: antennal morphogenesis
namespace: biological_process
def:
  "The process in which the anatomical structures of the antenna are generated and organized." [GOC:jid]


id: GO:0048801
name: antennal joint morphogenesis
namespace: biological_process
def:
  "The process in which the anatomical structures of the antennal joint are generated and organized." [GOC:jid]


id: GO:0048802
name: notum morphogenesis
namespace: biological_process
def:
  "The process in which the anatomical structures of the dorsal part of the body are generated and organized." [GOC:jid]


id: GO:0048803
name: imaginal disc-derived male genitalia morphogenesis
namespace: biological_process
def:
  "The process in which the anatomical structures of male genitalia are generated and organized from the genital imaginal disc." [GOC:ai, GOC:sensu]


id: GO:0048804
name: imaginal disc-derived female genitalia morphogenesis
namespace: biological_process
def:
  "The process in which the anatomical structures of female genitalia are generated and organized from the genital disc." [GOC:ai, GOC:sensu]


id: GO:0048805
name: imaginal disc-derived genitalia morphogenesis
namespace: biological_process
def:
  "The process in which the anatomical structures of genitalia are generated and organized from the genital imaginal disc." [GOC:ai, GOC:sensu]


id: GO:0048806
name: genitalia development
namespace: biological_process
def:
  "The process whose specific outcome is the progression of the genitalia over time, from its formation to the mature structure." [GOC:jid]


id: GO:0048807
name: female genitalia morphogenesis
namespace: biological_process
def:
  "The process in which the anatomical structures of female genitalia are generated and organized." [GOC:mah]


id: GO:0048808
name: male genitalia morphogenesis
namespace: biological_process
def:
  "The process in which the anatomical structures of male genitalia are generated and organized." [GOC:ems, ISBN:0140512888]


id: GO:0048809
name: analia morphogenesis
namespace: biological_process
def:
  "The process in which the anatomical structures of analia are generated and organized. The analia is the posterior-most vertral appendage that develops from the genital disc. An example of this process is analia morphogenesis in Drosophila melanogaster." [GOC:ai, GOC:mtg_sensu]


id: GO:0048810
name: female analia morphogenesis
namespace: biological_process
def:
  "The process in which the anatomical structures of the analia of the female are generated and organized. The analia is the posterior-most vertral appendage that develops from the genital disc. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:11494318]


id: GO:0048811
name: male analia morphogenesis
namespace: biological_process
def:
  "The process in which the anatomical structures of the analia of the male are generated and organized. The analia is the posterior-most vertral appendage that develops from the genital disc." [GOC:mtg_sensu, PMID:11494318]


id: GO:0048812
name: neuron projection morphogenesis
namespace: biological_process
def:
  "The process in which the anatomical structures of a neuron projection are generated and organized. A neuron projection is any process extending from a neural cell, such as axons or dendrites." [GOC:mah]


id: GO:0048813
name: dendrite morphogenesis
namespace: biological_process
def:
  "The process in which the anatomical structures of a dendrite are generated and organized. A dendrite is a freely branching protoplasmic process of a nerve cell." [GOC:jl, ISBN:0198506732]


id: GO:0048815
name: hermaphrodite genitalia morphogenesis
namespace: biological_process
def:
  "The process in which the anatomical structures of hermaphrodite genitalia are generated and organized." [GOC:ems, ISBN:0140512888]


id: GO:0048816
name: ocellus morphogenesis
namespace: biological_process
def:
  "The process in which the anatomical structures of the ocellus are generated and organized. The ocellus is a simple visual organ of insects." [http://fly.ebi.ac.uk/.bin/cvreport2?id=FBcv0004540]


id: GO:0048817
name: negative regulation of hair follicle maturation
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of hair follicle maturation." [GOC:devbiol]


id: GO:0048818
name: positive regulation of hair follicle maturation
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of hair follicle maturation." [GOC:devbiol]


id: GO:0048819
name: regulation of hair follicle maturation
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of hair follicle maturation." [GOC:devbiol]


id: GO:0048820
name: hair follicle maturation
namespace: biological_process
def:
  "A developmental process, independent of morphogenetic (shape) change, that is required for a hair follicle to attain its fully functional state." [GOC:devbiol]


id: GO:0048821
name: erythrocyte development
namespace: biological_process
def:
  "The process whose specific outcome is the progression of an erythrocyte over time, from its formation to the mature structure." [GOC:devbiol]


id: GO:0048822
name: enucleate erythrocyte development
namespace: biological_process
def:
  "The process aimed at the progression of an enucleate erythrocyte over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell." [GOC:devbiol]


id: GO:0048823
name: nucleate erythrocyte development
namespace: biological_process
def:
  "The process aimed at the progression of a nucleate erythrocyte over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell." [GOC:devbiol]


id: GO:0048824
name: pigment cell precursor differentiation
namespace: biological_process
def:
  "The process in which a relatively unspecialized cell acquires specialized features of a pigment cell precursor." [GOC:dgh, PMID:16499899]


id: GO:0048825
name: cotyledon development
namespace: biological_process
def:
  "The process whose specific outcome is the progression of the cotyledon over time, from its formation to the mature structure. The cotyledon is the modified leaf (seed leaf), found as part of the embryo in plant seeds. It is involved in either storage or absorption of food reserves. Dicotyledonous seeds contain two cotyledons, while monocotyledonous seeds contain only one. The cotyledons may appear above ground and show photosynthetic activity in the seedling." [GOC:devbiol, GOC:tb, PO:0020030]


id: GO:0048826
name: cotyledon morphogenesis
namespace: biological_process
def:
  "The process in which the anatomical structures of the cotyledon are generated and organized. The cotyledon is the modified leaf (seed leaf), found as part of the embryo in plant seeds. It is involved in either storage or absorption of food reserves. Dicotyledonous seeds contain two cotyledons, while monocotyledonous seeds contain only one. The cotyledons may appear above ground and show photosynthetic activity in the seedling." [GOC:devbiol, GOC:tb, PO:0020030]


id: GO:0048827
name: phyllome development
namespace: biological_process
def:
  "The process whose specific outcome is the progression of a phyllome over time, from its formation to the mature structure. A phyllome is a collective term for all the different types of leaves appearing on plants." [GOC:devbiol, GOC:tb, PO:0006001]


id: GO:0048829
name: root cap development
namespace: biological_process
def:
  "The process whose specific outcome is the progression of the root cap over time, from its formation to the mature structure. The root cap protects the root meristem from friction as the root grows through the soil. The cap is made up of a group of parenchyma cells which secrete a glycoprotein mucilage as a lubricant." [GOC:tb]


id: GO:0048830
name: adventitious root development
namespace: biological_process
def:
  "The process whose specific outcome is the progression of adventitious root over time, from its formation to the mature structure. Adventitious roots are post-embryonic roots that develop from the plant shoot." [GOC:tb]


id: GO:0048831
name: regulation of shoot system development
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of shoot development." [GOC:tb, PMID:16361392]


id: GO:0048832
name: specification of organ number
namespace: biological_process
def:
  "The regionalization process that modulates the quantity of a particular type of organ." [GOC:dph, GOC:isa_complete, GOC:tb]


id: GO:0048837
name: sorus development
namespace: biological_process
def:
  "The process whose specific outcome is the progression of the sorus over time, from its formation to the mature structure. A sorus is a mass of spores." [dictyBase_REF:2530, GOC:devbiol, GOC:mtg_sensu]


id: GO:0048838
name: release of seed from dormancy
namespace: biological_process
def:
  "The process in which the dormant state is broken in a seed. Dormancy is characterized by a suspension of physiological activity that can be reactivated upon release." [GOC:dph, GOC:jid, GOC:tb, ISBN:9781405139830]


id: GO:0048839
name: inner ear development
namespace: biological_process
def:
  "The process whose specific outcome is the progression of the inner ear over time, from its formation to the mature structure." [GOC:sr]


id: GO:0048840
name: otolith development
namespace: biological_process
def:
  "The process whose specific outcome is the progression of the otolith over time, from its formation to the mature structure." [GOC:sr]


id: GO:0048841
name: regulation of axon extension involved in axon guidance
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of axon extension involved in axon guidance." [GOC:devbiol]


id: GO:0048842
name: positive regulation of axon extension involved in axon guidance
namespace: biological_process
def:
  "Any process that activates, maintains or increases the frequency, rate or extent of axon extension involved in axon guidance." [GOC:devbiol]


id: GO:0048843
name: negative regulation of axon extension involved in axon guidance
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of axon extension involved in axon guidance." [GOC:devbiol]


id: GO:0048844
name: artery morphogenesis
namespace: biological_process
def:
  "The process in which the anatomical structures of arterial blood vessels are generated and organized. Arteries are blood vessels that transport blood from the heart to the body and its organs." [GOC:dsf, PMID:16740480]


id: GO:0048845
name: venous blood vessel morphogenesis
namespace: biological_process
def:
  "The process in which the anatomical structures of venous blood vessels are generated and organized. Veins are blood vessels that transport blood from the body and its organs to the heart." [GOC:dsf, PMID:16740480]


id: GO:0048846
name: axon extension involved in axon guidance
namespace: biological_process
def:
  "The long distance growth of a single cell process, that is involved in the migration of an axon growth cone, where the migration is directed to a specific target site by a combination of attractive and repulsive cues." [GOC:ef, GOC:jid]


id: GO:0048847
name: adenohypophysis formation
namespace: biological_process
def:
  "The process that gives rise to adenohypophysis. This process pertains to the initial formation of a structure from unspecified parts. The adenohypophysis is the anterior part of the pituitary. It secretes a variety of hormones and its function is regulated by the hypothalamus." [GOC:cvs, GOC:dgh, GOC:dph, GOC:jid]


id: GO:0048848
name: neurohypophysis morphogenesis
namespace: biological_process
def:
  "The process in which the anatomical structures of the neurohypophysis are generated and organized. The neurohypophysis is the part of the pituitary gland that secretes hormones involved in blood pressure regulation." [GOC:cls, GOC:dgh, GOC:dph, GOC:jid]


id: GO:0048849
name: neurohypophysis formation
namespace: biological_process
def:
  "The process that gives rise to neurohypophysis. This process pertains to the initial formation of a structure from unspecified parts. The neurohypophysis is the part of the pituitary gland that secretes hormones involved in blood pressure regulation." [GOC:cls, GOC:dgh, GOC:dph, GOC:jid]


id: GO:0048850
name: hypophysis morphogenesis
namespace: biological_process
def:
  "The process in which the anatomical structures of the hypophysis are generated and organized. The pituitary gland is an endocrine gland that secretes hormones that regulate many other glands." [GOC:cls, GOC:dgh, GOC:dph, GOC:jid]


id: GO:0048851
name: hypophysis formation
namespace: biological_process
def:
  "The process in which the anatomical structures of the hypophysis are generated and organized. The hypophysis is an endocrine gland that secretes hormones that regulate many other glands." [GOC:cls, GOC:dgh, GOC:dph, GOC:jid]


id: GO:0048852
name: diencephalon morphogenesis
namespace: biological_process
def:
  "The process in which the anatomical structures of the diencephalon are generated and organized. The diencephalon is the paired caudal parts of the prosencephalon from which the thalamus, hypothalamus, epithalamus and subthalamus are derived; these regions regulate autonomic, visceral and endocrine function, and process information directed to the cerebral cortex." [GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]


id: GO:0048853
name: forebrain morphogenesis
namespace: biological_process
def:
  "The process in which the anatomical structures of the forebrain are generated and organized. The forebrain is the anterior of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes especially the cerebral hemispheres, the thalamus, and the hypothalamus and especially in higher vertebrates is the main control center for sensory and associative information processing, visceral functions, and voluntary motor functions)." [GOC:cvs, GOC:dgh, GOC:dph, GOC:jid]


id: GO:0048854
name: brain morphogenesis
namespace: biological_process
def:
  "The process in which the anatomical structures of the brain are generated and organized. The brain is one of the two components of the central nervous system and is the center of thought and emotion. It is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)." [GOC:dgh, GOC:jid]


id: GO:0048855
name: adenohypophysis morphogenesis
namespace: biological_process
def:
  "The process in which the anatomical structures of the adenohypophysis are generated and organized. The adenohypophysis is the anterior part of the pituitary. It secretes a variety of hormones and its function is regulated by the hypothalamus." [GOC:cvs, GOC:dgh, GOC:dph, GOC:jid]


id: GO:0048856
name: anatomical structure development
namespace: biological_process
def:
  "The biological process whose specific outcome is the progression of an anatomical structure from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome." [GO_REF:0000021, GOC:mtg_15jun06]


id: GO:0048857
name: neural nucleus development
namespace: biological_process
def:
  "The biological process whose specific outcome is the progression of a neural nucleus from its initial condition to its mature state. A neural nucleus is an anatomical structure consisting of a discrete aggregate of neuronal soma." [GO_REF:0000021, GOC:mtg_15jun06]


id: GO:0048858
name: cell projection morphogenesis
namespace: biological_process
def:
  "The process in which the anatomical structures of a cell projection are generated and organized." [GO_REF:0000021, GOC:mtg_15jun06]


id: GO:0048859
name: formation of anatomical boundary
namespace: biological_process
def:
  "The process in which the limits of an anatomical structure are generated. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome." [GO_REF:0000021, GOC:mtg_15jun06]


id: GO:0048860
name: glioblast division
namespace: biological_process
def:
  "The process resulting in the physical partitioning and separation of a glioblast into daughter cells." [GOC:devbiol]


id: GO:0048861
name: leukemia inhibitory factor signaling pathway
namespace: biological_process
def:
  "Any series of molecular signals initiated by the binding of leukemia inhibitory factor to a receptor on the surface of the target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:devbiol, GOC:signaling]


id: GO:0048863
name: stem cell differentiation
namespace: biological_process
def:
  "The process in which a relatively unspecialized cell acquires specialized features of a stem cell. A stem cell is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized cells." [CL:0000034, GOC:isa_complete]


id: GO:0048864
name: stem cell development
namespace: biological_process
def:
  "The process whose specific outcome is the progression of the stem cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to its specific fate." [CL:0000034, GOC:isa_complete]


id: GO:0048865
name: stem cell fate commitment
namespace: biological_process
def:
  "The process in which the developmental fate of a cell becomes restricted such that it will develop into a stem cell." [CL:0000034, GOC:isa_complete]


id: GO:0048866
name: stem cell fate specification
namespace: biological_process
def:
  "The process in which a cell becomes capable of differentiating autonomously into a stem cell in an environment that is neutral with respect to the developmental pathway. Upon specification, the cell fate can be reversed." [CL:0000034, GOC:isa_complete]


id: GO:0048867
name: stem cell fate determination
namespace: biological_process
def:
  "The process in which a cell becomes capable of differentiating autonomously into a stem cell regardless of its environment; upon determination, the cell fate cannot be reversed." [CL:0000034, GOC:isa_complete]


id: GO:0048868
name: pollen tube development
namespace: biological_process
def:
  "The process whose specific outcome is the progression of a pollen tube over time, from its initial formation to a mature structure." [GOC:isa_complete]


id: GO:0048869
name: cellular developmental process
namespace: biological_process
def:
  "A biological process whose specific outcome is the progression of a cell over time from an initial condition to a later condition." [GOC:isa_complete]


id: GO:0048870
name: cell motility
namespace: biological_process
def:
  "Any process involved in the controlled self-propelled movement of a cell that results in translocation of the cell from one place to another." [GOC:dgh, GOC:dph, GOC:isa_complete, GOC:mlg]


id: GO:0048871
name: multicellular organismal homeostasis
namespace: biological_process
def:
  "Any process involved in the maintenance of an internal steady state at the level of the multicellular organism." [GOC:isa_complete]


id: GO:0048872
name: homeostasis of number of cells
namespace: biological_process
def:
  "Any biological process involved in the maintenance of the steady-state number of cells within a population of cells." [GOC:isa_complete]


id: GO:0048873
name: homeostasis of number of cells within a tissue
namespace: biological_process
def:
  "Any biological process involved in the maintenance of the steady-state number of cells within a population of cells in a tissue." [GOC:isa_complete]


id: GO:0048874
name: homeostasis of number of cells in a free-living population
namespace: biological_process
def:
  "The biological process involved in maintaining the steady-state number of cells within a population of free-living cells such as the bacteria in the gut." [GOC:isa_complete]


id: GO:0048875
name: chemical homeostasis within a tissue
namespace: biological_process
def:
  "Any process involved in the maintenance of the internal steady state of the amount of a chemical at the level of the tissue." [GOC:isa_complete]


id: GO:0048876
name: chemical homeostasis within retina
namespace: biological_process
def:
  "Any process involved in the maintenance of the internal steady state of the amount of a chemical at the level of the retina." [GOC:isa_complete]


id: GO:0048877
name: homeostasis of number of retina cells
namespace: biological_process
def:
  "Any biological process involved in the maintenance of the steady-state number of cells within a population of cells in the retina." [GOC:dph, GOC:isa_complete, GOC:tb]


id: GO:0048878
name: chemical homeostasis
namespace: biological_process
def:
  "Any biological process involved in the maintenance of an internal steady state of a chemical." [GOC:isa_complete]


id: GO:0048880
name: sensory system development
namespace: biological_process
def:
  "The process whose specific outcome is the progression of a sensory system over time from its formation to the mature structure." [GOC:dgh]


id: GO:0048881
name: mechanosensory lateral line system development
namespace: biological_process
def:
  "The process whose specific outcome is the progression of the mechanosensory lateral line system over time, from its formation to the mature structure. The mechanosensory lateral line system consists of small sensory patches (neuromasts) located superficially on the skin or just under the skin in fluid-filled canals on the head and body of all fishes and most amphibians. The neuromasts are innervated by several lateral line nerves, which project primarily to the hindbrain. The mechanosensory lateral line system is stimulated by local water displacements and vibrations, and detects propulsion of the fish through the water, as well as facilitating shoaling, prey capture, and predator and obstacle avoidance." [ISBN:0125296509]


id: GO:0048882
name: lateral line development
namespace: biological_process
def:
  "The process whose specific outcome is the progression of the lateral line over time, from its formation to the mature structure. The lateral line consists of small sensory patches (neuromasts) located superficially on the skin or just under the skin in fluid-filled canals on the head and body of all fishes and most amphibians. The lateral line develops from cranial ectodermal placodes situated behind the ear and between the eye and ear." [ISBN:0125296509]


id: GO:0048883
name: neuromast primordium migration
namespace: biological_process
def:
  "The migration of a cluster of a relatively undifferentiated cell originating at specific cephalic placodes and depositing proneuromasts along a developing lateral line, from which the neuromasts will develop." [PMID:15018940, PMID:15832385]


id: GO:0048884
name: neuromast development
namespace: biological_process
def:
  "The process whose specific outcome is the progression of the neuromast over time, from its formation to the mature structure. The neuromast is the sensory organ of the lateral line and is composed of a population of sensory hair cells, and nonsensory supporting cells and mantle cells. Neuromasts are located superficially on the epithelium or in lateral line canals." [ISBN:0125296509]


id: GO:0048885
name: neuromast deposition
namespace: biological_process
def:
  "The process in which a migrating neuromast primordium deposits clusters of undifferentiated cells (proneuromasts) along its migratory path in a developing lateral line." [PMID:15018940]


id: GO:0048886
name: neuromast hair cell differentiation
namespace: biological_process
def:
  "The process in which a relatively unspecialized cell acquires specialized features of a neuromast hair cell. Hair cells are the sensory receptors of the neuromast and are located in a portion of the neuromast called the sensory strip. Each hair cell of the neuromast is morphologically polarized as a result of the relative position of the single kinocilium and the clusters of stereocilia on its apical surface. There are approximately seven hair cells within each neuromast, with each hair cell innervated by afferent and efferent neurons." [CL:0000856, ISBN:0125296509]


id: GO:0048887
name: cupula development
namespace: biological_process
def:
  "The process whose specific outcome is the progression of the cupula over time, from its formation to the mature structure. The cupula is secreted by mantle cells and the ciliary bundles of all of the hair cells of the neuromast are embedded in it. The cupula provides a mechanical linkage between the hair cells and the external hydrodynamic environment. The cupula of superficial neuromasts grows continuously, while the height of the cupula of canal neuromasts is limited by canal diameter." [ISBN:0125296509]


id: GO:0048888
name: neuromast mantle cell differentiation
namespace: biological_process
def:
  "The process in which a relatively unspecialized cell acquires specialized features of a neuromast mantle cell. Mantle cells are non-sensory cells that surround the sensory strip, separating the neuromast from the epidermis. Mantle cells secrete the cupula in which the ciliary bundles of all of the hair cells are embedded." [ISBN:0125296509]


id: GO:0048889
name: neuromast support cell differentiation
namespace: biological_process
def:
  "The process in which a relatively unspecialized cell acquires specialized features of a neuromast support cell. Support cells are non-sensory cells of the neuromast that extend between the sensory hair cells from the basement membrane to the apical surface; they are surrounded by mantle cells." [ISBN:0125296509]


id: GO:0048890
name: lateral line ganglion development
namespace: biological_process
def:
  "The process whose specific outcome is the progression of the lateral line ganglion over time, from its formation to the mature structure. The lateral line ganglion develops from cranial ectodermal placodes situated between the eye and ear and behind the ear." [ISBN:0125296509, ISBN:0387968377]


id: GO:0048891
name: lateral line ganglion neuron differentiation
namespace: biological_process
def:
  "The process in which a relatively unspecialized cell acquires specialized features of a lateral line ganglion neuron." [PMID:15018940]


id: GO:0048892
name: lateral line nerve development
namespace: biological_process
def:
  "The process whose specific outcome is the progression of the lateral line nerve over time, form its formation to the mature structure. Lateral line nerves project primarily to an octavolateralis column in the hindbrain that consists of the medial octavolateralis nucleus (MON), the caudal octavolateralis nucleus, and the magnocellular nucleus." [ISBN:0125296509]


id: GO:0048893
name: afferent axon development in lateral line nerve
namespace: biological_process
def:
  "The process whose specific outcome is the progression of an afferent axon in a lateral line nerve over time from its formation to the mature structure. This process includes axonogenesis and pathfinding of the afferent axons in any lateral line nerve." [PMID:15832385]


id: GO:0048894
name: efferent axon development in a lateral line nerve
namespace: biological_process
def:
  "The process whose specific outcome is the progression of an efferent axon in a lateral line nerve over time from its formation to the mature structure. This process includes axonogenesis and pathfinding of the efferent axons in any lateral line nerve." [PMID:15832385]


id: GO:0048895
name: lateral line nerve glial cell differentiation
namespace: biological_process
def:
  "The process in which a relatively unspecialized cell acquires specialized features of a glial cell in a lateral line nerve." [PMID:12062041]


id: GO:0048898
name: anterior lateral line system development
namespace: biological_process
def:
  "The process whose specific outcome is the progression of the anterior lateral line system over time, from its formation to the mature structure. The anterior lateral line system develops from cranial ectodermal placodes, situated between the eye and the ear, that give rise to both the neuromasts and the anterior lateral line sensory nerves that innervate the neuromasts. The anterior lateral line system consists of small sensory patches (neuromasts) located superficially on the skin or just under the skin in fluid-filled canals on the head of all fishes and most amphibians and are innervated by several lateral line nerves, which project to the hindbrain. The anterior lateral line system is stimulated by local water displacements and vibrations, and detects propulsion of the fish through the water, as well as facilitating shoaling, prey capture, and predator and obstacle avoidance." [ISBN:0125296509, PMID:15018940]


id: GO:0048899
name: anterior lateral line development
namespace: biological_process
def:
  "The process whose specific outcome is the progression of the anterior lateral line over time, from its formation to the mature structure. The anterior lateral line consists of small sensory patches (neuromasts) located superficially on the skin or just under the skin in fluid-filled canals on the head of all fishes and most amphibians. The anterior lateral line develops from cranial ectodermal placodes situated between the eye and ear." [ISBN:0125296509]


id: GO:0048900
name: anterior lateral line neuromast primordium migration
namespace: biological_process
def:
  "The migration of a cluster of a relatively undifferentiated cell along the developing anterior lateral line, originating from cranial ectodermal placodes situated between the eye and the ear. The neuromast primordium deposits proneuromasts along the lateral line, from which the neuromasts will develop." [GOC:dgh, PMID:15832385]


id: GO:0048901
name: anterior lateral line neuromast development
namespace: biological_process
def:
  "The process whose specific outcome is the progression of the anterior lateral line neuromast over time, from its formation to the mature structure. The neuromast is the sensory receptor of the anterior lateral line system and is composed of a population of sensory hair cells, and nonsensory supporting cells and mantle cells. Neuromast are located superficially on the epithelium or in lateral line canals." [ISBN:0125296509]


id: GO:0048902
name: anterior lateral line neuromast deposition
namespace: biological_process
def:
  "The process in which a migrating neuromast primordium deposits clusters of undifferentiated cells (proneuromasts) along its migratory path in the developing anterior lateral line." [PMID:15832385]


id: GO:0048903
name: anterior lateral line neuromast hair cell differentiation
namespace: biological_process
def:
  "The process in which a relatively unspecialized cell acquires specialized features of an anterior lateral line neuromast hair cell. Neuromast hair cells are the sensory receptors of the neuromast and are located in a portion of the neuromast called the sensory strip. Each hair cell of the neuromast is morphologically polarized as a result of the relative position of the single kinocilium and the clusters of stereocilia on its apical surface. There are approximately seven hair cells within each neuromast, with each hair cell innervated by afferent and efferent neurons." [ISBN:0125296509, ISBN:0387968377]


id: GO:0048904
name: anterior lateral line neuromast cupula development
namespace: biological_process
def:
  "The process whose specific outcome is the progression of the anterior lateral line neuromast cupula over time, from its formation to the mature structure. The cupula is secreted by mantle cells and the ciliary bundles of all of the hair cells of the neuromast are embedded in it. The cupula provides a mechanical linkage between the hair cells and the external hydrodynamic environment. The cupula of superficial neuromasts grows continuously, while the height of the cupula of canal neuromasts is limited by canal diameter." [ISBN:0125296509]


id: GO:0048905
name: anterior lateral line neuromast mantle cell differentiation
namespace: biological_process
def:
  "The process in which a relatively unspecialized cell acquires specialized features of an anterior lateral line neuromast mantle cell. Mantle cells are non-sensory cells that surround the sensory strip, separating the neuromast from the epidermis. Mantle cells secrete the cupula in which the ciliary bundles of all of the hair cells are embedded." [ISBN:0125296509]


id: GO:0048906
name: anterior lateral line neuromast support cell differentiation
namespace: biological_process
def:
  "The process in which a relatively unspecialized cell acquires specialized features of an anterior lateral line neuromast support cell. Support cells are non-sensory cells of the neuromast that extend between the sensory hair cells from the basement membrane to the apical surface; they are surrounded by mantle cells." [ISBN:0387968377]


id: GO:0048907
name: anterior lateral line ganglion development
namespace: biological_process
def:
  "The process whose specific outcome is the progression of the anterior lateral line ganglion over time, from its formation to the mature structure. The anterior lateral line ganglion develops from cranial ectodermal placodes situated between the eye and ear." [ISBN:0125296509]


id: GO:0048908
name: anterior lateral line ganglion neuron differentiation
namespace: biological_process
def:
  "The process in which a relatively unspecialized cell acquires specialized features of a neuron of the anterior lateral line ganglion." [PMID:15018940]


id: GO:0048909
name: anterior lateral line nerve development
namespace: biological_process
def:
  "The process whose specific outcome is the progression of the anterior lateral line nerve over time, form its formation to the mature structure. The anterior lateral line nerve contains efferent axons that innervate hair cells of the ALL and afferent axons that project to an octavolateralis column in the hindbrain. The octavolateralis column consists of the medial octavolateralis nucleus (MON), the caudal octavolateralis nucleus, and the magnocellular nucleus." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0125296509]


id: GO:0048910
name: afferent axon development in anterior lateral line nerve
namespace: biological_process
def:
  "The process whose specific outcome is the progression of an afferent axon in the anterior lateral line nerve over time from its formation to the mature structure. This process includes axonogenesis and pathfinding of the afferent axons in the anterior lateral line nerve." [PMID:15018940]


id: GO:0048911
name: efferent axon development in anterior lateral line nerve
namespace: biological_process
def:
  "The process whose specific outcome is the progression of an efferent axon in the anterior lateral line nerve over time from its formation to the mature structure. This process includes axonogenesis and pathfinding of the efferent axons in the anterior lateral line nerve." [PMID:15018940]


id: GO:0048913
name: anterior lateral line nerve glial cell differentiation
namespace: biological_process
def:
  "The process in which a relatively unspecialized cell acquires specialized features of a glial cell in the anterior lateral line nerve." [PMID:15832385]


id: GO:0048914
name: myelination of anterior lateral line nerve axons
namespace: biological_process
def:
  "The formation of compact myelin sheaths around the axons of the anterior lateral line nerve." [PMID:12112375]


id: GO:0048915
name: posterior lateral line system development
namespace: biological_process
def:
  "The process whose specific outcome is the progression of the posterior lateral line system over time, from its formation to the mature structure. The posterior lateral line system develops from cranial ectodermal placodes, situated behind the ear, that give rise to both the neuromasts and the posterior lateral line sensory nerves that innervate the neuromasts. The posterior lateral line system consists of small sensory patches (neuromasts) located superficially on the skin or just under the skin in fluid-filled canals on the head of all fishes and most amphibians. The neuromasts are innervated by several lateral line nerves, which project primarily to the hindbrain. The posterior mechanosensory lateral line system is stimulated by local water displacements and vibrations, and detects propulsion of the fish through the water, as well as facilitating shoaling, prey capture, and predator and obstacle avoidance." [ISBN:0125296509, PMID:15018940]


id: GO:0048916
name: posterior lateral line development
namespace: biological_process
def:
  "The process whose specific outcome is the progression of the posterior lateral line over time, from its formation to the mature structure. The posterior lateral line consists of small sensory patches (neuromasts) located superficially on the skin or just under the skin in fluid-filled canals on the body and trunk of all fishes and most amphibians. The posterior lateral line develops from cranial ectodermal placodes situated behind the ear." [ISBN:0125296509]


id: GO:0048917
name: posterior lateral line ganglion development
namespace: biological_process
def:
  "The process whose specific outcome is the progression of the posterior lateral line ganglion over time, from its formation to the mature structure. The posterior lateral line ganglion develops from cranial ectodermal placodes situated behind the ear." [ISBN:0125296509, ISBN:0387968377]


id: GO:0048918
name: posterior lateral line nerve development
namespace: biological_process
def:
  "The process whose specific outcome is the progression of the posterior lateral line nerve over time, from its formation to the mature structure. The posterior lateral line nerve innervates hair cells of the PLL and projects to an octavolateralis column in the hindbrain that consists of the medial octavolateralis nucleus (MON), the caudal octavolateralis nucleus, and the magnocellular nucleus." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0125296509]


id: GO:0048919
name: posterior lateral line neuromast development
namespace: biological_process
def:
  "The process whose specific outcome is the progression of the posterior lateral line neuromast over time, from its formation to the mature structure. The neuromast is the sensory receptor of the anterior lateral line system and is composed of a population of sensory hair cells, and nonsensory supporting cells and mantle cells. Neuromast are located superficially on the epithelium or in lateral line canals." [ISBN:0125296509]


id: GO:0048920
name: posterior lateral line neuromast primordium migration
namespace: biological_process
def:
  "The migration of a relatively undifferentiated cell along the developing posterior lateral line, originating from cranial ectodermal placodes situated behind the ear. The neuromast primordium deposits proneuromasts along the lateral line, from which the neuromasts will develop." [GOC:dgh, PMID:15832385]


id: GO:0048921
name: posterior lateral line neuromast cupula development
namespace: biological_process
def:
  "The process whose specific outcome is the progression of the posterior lateral line neuromast cupula over time, from its formation to the mature structure. The cupula is secreted by mantle cells and the ciliary bundles of all of the hair cells of the neuromast are embedded in it. The cupula provides a mechanical linkage between the hair cells and the external hydrodynamic environment. The cupula of superficial neuromasts grows continuously, while the height of the cupula of canal neuromasts is limited by canal diameter." [ISBN:0125296509]


id: GO:0048922
name: posterior lateral line neuromast deposition
namespace: biological_process
def:
  "The process in which a migrating neuromast primordium deposits clusters of undifferentiated cells (proneuromasts) along its migratory path in the developing posterior lateral line." [PMID:15832385]


id: GO:0048923
name: posterior lateral line neuromast hair cell differentiation
namespace: biological_process
def:
  "The process in which a relatively unspecialized cell acquires specialized features of a posterior lateral line neuromast hair cell. (N.B. This may be development of neuromast hair cell type or a set of cell of neuromast hair cell type. This will involve the change of a cell or set of cells from one cell identity to another). Hair cells are the sensory receptors of the neuromast and are located in a portion of the neuromast called the sensory strip. Each hair cell of the neuromast is morphologically polarized as a result of the relative position of the single kinocilium and the clusters of stereocilia on its apical surface. There are approximately seven hair cells within each neuromast, with each hair cell innervated by afferent and efferent neurons." [ISBN:0125296509]


id: GO:0048924
name: posterior lateral line neuromast mantle cell differentiation
namespace: biological_process
def:
  "The process in which a relatively unspecialized cell acquires specialized features of a posterior lateral line neuromast mantle cell. (N.B. This may be development of neuromast mantle cell type or a set of cells of neuromast mantle cell type. This will involve the change of a cell or set of cells from one cell identity to another). Mantle cells are non-sensory cells that surround the sensory strip, separating the neuromast from the epidermis. Mantle cells secrete the cupula in which the ciliary bundles of all of the hair cells are embedded." [ISBN:0125296509]


id: GO:0048925
name: lateral line system development
namespace: biological_process
def:
  "The process whose specific outcome is the progression of the lateral line system over time, from its formation to the mature structure. The lateral line system is a network of sensory organs (neuromasts) and lateral line nerves located superficially on the skin or just under the skin in fluid-filled canals on the head and body of all fishes and most amphibians. The lateral line system develops from cranial ectodermal placodes situated between the eye and ear." [GOC:dgh, ISBN:0125296509]


id: GO:0048926
name: electrosensory lateral line system development
namespace: biological_process
def:
  "The process whose specific outcome is the progression of the electrosensory lateral line system over time, from its formation to the mature structure." [GOC:dgh]


id: GO:0048927
name: posterior lateral line neuromast support cell differentiation
namespace: biological_process
def:
  "The process in which a relatively unspecialized cell acquires specialized features of a posterior lateral line neuromast support cell. Support cells are non-sensory cells of the neuromast that extend between the sensory hair cells from the basement membrane to the apical surface; they are surrounded by mantle cells." [ISBN:0387968377]


id: GO:0048928
name: posterior lateral line ganglion neuron differentiation
namespace: biological_process
def:
  "The process in which a relatively unspecialized cell acquires specialized features of a neuron of the posterior lateral line ganglion." [PMID:15018940]


id: GO:0048929
name: efferent axon development in posterior lateral line nerve
namespace: biological_process
def:
  "The process whose specific outcome is the progression of an efferent axon in the posterior lateral line nerve over time from its formation to the mature structure. This process includes axonogenesis and pathfinding of the efferent axons in the posterior lateral line nerve." [PMID:15018940]


id: GO:0048931
name: posterior lateral line nerve glial cell differentiation
namespace: biological_process
def:
  "The process in which a relatively unspecialized cell acquires specialized features of a glial cell in the posterior lateral line nerve." [PMID:15832385]


id: GO:0048932
name: myelination of posterior lateral line nerve axons
namespace: biological_process
def:
  "The formation of compact myelin sheaths around the axons of the posterior lateral line nerve." [PMID:12112375]


id: GO:0048933
name: afferent axon development in posterior lateral line nerve
namespace: biological_process
def:
  "The process whose specific outcome is the progression of an afferent axon in the posterior lateral line nerve over time from its formation to the mature structure. This process includes axonogenesis and pathfinding of the afferent axons in the posterior lateral line nerve." [PMID:15018940]


id: GO:0048934
name: peripheral nervous system neuron differentiation
namespace: biological_process
def:
  "The process in which a relatively unspecialized cell acquires specialized features of a neuron whose cell body resides in the peripheral nervous system." [GOC:dgh]


id: GO:0048935
name: peripheral nervous system neuron development
namespace: biological_process
def:
  "The process whose specific outcome is the progression of a neuron whose cell body is located in the peripheral nervous system, from initial commitment of the cell to a neuronal fate, to the fully functional differentiated neuron." [GOC:dgh]


id: GO:0048936
name: peripheral nervous system neuron axonogenesis
namespace: biological_process
def:
  "Generation of a long process from a neuron whose cell body resides in the peripheral nervous system. The axon carries action potential from the cell body towards target cells." [GOC:dgh]


id: GO:0048937
name: lateral line nerve glial cell development
namespace: biological_process
def:
  "The process aimed at the progression of a lateral line glial cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell." [GOC:dgh]


id: GO:0048938
name: lateral line nerve glial cell morphogenesis involved in differentiation
namespace: biological_process
def:
  "The process in which the structure of a glial cell in a lateral line nerve is generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of a glial cell in a lateral line nerve." [GOC:dgh]


id: GO:0048939
name: anterior lateral line nerve glial cell development
namespace: biological_process
def:
  "The process aimed at the progression of a glial cell in the anterior lateral line nerve over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell." [GOC:dgh]


id: GO:0048940
name: anterior lateral line nerve glial cell morphogenesis involved in differentiation
namespace: biological_process
def:
  "The process in which the structures of a glial cell in the anterior lateral line nerve are generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of a glial cell in the anterior lateral line nerve." [GOC:dgh]


id: GO:0048941
name: posterior lateral line nerve glial cell development
namespace: biological_process
def:
  "The process aimed at the progression of a glial cell in the posterior lateral line nerve over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell." [GOC:dgh]


id: GO:0048942
name: posterior lateral line nerve glial cell morphogenesis involved in differentiation
namespace: biological_process
def:
  "The process in which the structures of a glial cell in the posterior lateral line nerve are generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of a glial cell in the posterior lateral line nerve." [GOC:dgh]


id: GO:0050000
name: chromosome localization
namespace: biological_process
def:
  "Any process in which a chromosome is transported to, or maintained in, a specific location." [GOC:ai]


id: GO:0050001
name: D-glutaminase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: H2O + L-glutamine = NH3 + D-glutamate." [EC:3.5.1.35, MetaCyc:D-GLUTAMINASE-RXN]


id: GO:0050002
name: D-proline reductase (dithiol) activity
namespace: molecular_function
def:
  "Catalysis of the reaction: lipoate + 5-aminopentanoate = dihydrolipoate + D-proline." [EC:1.21.4.1, MetaCyc:D-PROLINE-REDUCTASE-(DITHIOL)-RXN]


id: GO:0050003
name: deoxycytidylate C-methyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 5,10-methylenetetrahydrofolate + dCMP = 2'-deoxy-5-methyl-5'-cytidylate + 7,8-dihydrofolate." [EC:2.1.1.54, RHEA:11571]


id: GO:0050004
name: isoflavone 7-O-glucosyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: UDP-glucose + isoflavone = UDP + isoflavone 7-O-beta-D-glucoside." [EC:2.4.1.170, MetaCyc:ISOFLAVONE-7-O-GLUCOSYLTRANSFERASE-RXN]


id: GO:0050005
name: isohexenylglutaconyl-CoA hydratase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 3-hydroxy-3-(4-methylpent-3-en-1-yl)glutaryl-CoA = 3-(4-methylpent-3-en-1-yl)pent-2-enedioyl-CoA + H(2)O." [EC:4.2.1.57, RHEA:24147]


id: GO:0050006
name: isomaltulose synthase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: sucrose = 6-O-alpha-D-glucopyranosyl-D-fructofuranose." [EC:5.4.99.11, MetaCyc:ISOMALTULOSE-SYNTHASE-RXN]


id: GO:0050007
name: isonocardicin synthase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: S-adenosyl-L-methionine(1+) + nocardicin E = S-methyl-5'-thioadenosine + H(+) + isonocardicin A." [EC:2.5.1.38, RHEA:19848]


id: GO:0050009
name: isopropanol dehydrogenase (NADP+) activity
namespace: molecular_function
def:
  "Catalysis of the reaction: NADP(+) + propan-2-ol = acetone + H(+) + NADPH." [EC:1.1.1.80, RHEA:21795]


id: GO:0050010
name: isovitexin beta-glucosyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: isovitexin + UDP-D-glucose = H(+) + isovitexin 2''-O-beta-D-glucoside + UDP." [EC:2.4.1.106, RHEA:19532]


id: GO:0050011
name: itaconyl-CoA hydratase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: citramalyl-CoA = itaconyl-CoA + H2O." [EC:4.2.1.56, MetaCyc:ITACONYL-COA-HYDRATASE-RXN]


id: GO:0050012
name: juglone 3-monooxygenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 5-hydroxy-1,4-naphthoquinone + AH(2) + O(2) = 3,5-dihydroxy-1,4-naphthoquinone + A + H(2)O + H(+)." [EC:1.14.99.27, RHEA:18748]


id: GO:0050013
name: 2-dehydropantoate aldolase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 2-dehydropantoate = 3-methyl-2-oxobutanoate + formaldehyde." [EC:4.1.2.12, MetaCyc:KETOPANTOALDOLASE-RXN]


id: GO:0050014
name: ketotetrose-phosphate aldolase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: L-erythrulose 1-phosphate = formaldehyde + glycerone phosphate." [EC:4.1.2.2, RHEA:20935]


id: GO:0050015
name: kievitone hydratase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: kievitone hydrate = H(2)O + H(+) + kievitone." [EC:4.2.1.95, RHEA:23607]


id: GO:0050016
name: kynurenine 7,8-hydroxylase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: kynurenate + donor-H2 + O2 = 7,8-dihydro-7,8-dihydroxykynurenate + acceptor." [EC:1.14.99.2, MetaCyc:KYNURENINE-78-HYDROXYLASE-RXN]


id: GO:0050017
name: L-3-cyanoalanine synthase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: L-cysteine + HCN = sulfide + L-3-cyanoalanine." [EC:4.4.1.9, MetaCyc:L-3-CYANOALANINE-SYNTHASE-RXN]


id: GO:0050018
name: L-amino-acid dehydrogenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: an L-amino acid + H2O + NAD+ = a 2-oxo acid + NH3 + NADH." [EC:1.4.1.5, MetaCyc:L-AMINO-ACID-DEHYDROGENASE-RXN]


id: GO:0050019
name: L-arabinitol 4-dehydrogenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: L-arabinitol + NAD(+) = L-xylulose + H(+) + NADH." [EC:1.1.1.12, RHEA:16384]


id: GO:0050020
name: L-arabinonate dehydratase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: L-arabinonate = 2-dehydro-3-deoxy-L-arabinonate + H(2)O." [EC:4.2.1.25, RHEA:20971]


id: GO:0050021
name: L-arabinonolactonase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: L-arabinono-1,4-lactone + H(2)O = L-arabinonate + H(+)." [EC:3.1.1.15, RHEA:16220]


id: GO:0050022
name: L-arabinose 1-dehydrogenase (NAD+) activity
namespace: molecular_function
def:
  "Catalysis of the reaction: L-arabinose + NAD+ = L-arabinono-1,4-lactone + NADH." [EC:1.1.1.46, MetaCyc:L-ARABINOSE-1-DEHYDROGENASE-RXN]


id: GO:0050023
name: L-fuconate dehydratase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: L-fuconate = 2-dehydro-3-deoxy-L-fuconate + H(2)O." [EC:4.2.1.68, RHEA:22775]


id: GO:0050024
name: L-galactonolactone oxidase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: L-galactono-1,4-lactone + O(2) = L-ascorbate + H(2)O(2) + H(+)." [EC:1.3.3.12, RHEA:20620]


id: GO:0050025
name: L-glutamate oxidase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: L-glutamate + O2 + H2O = 2-oxoglutarate + NH3 + H2O2." [EC:1.4.3.11, MetaCyc:L-GLUTAMATE-OXIDASE-RXN]


id: GO:0050026
name: L-glycol dehydrogenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: an L-glycol + NAD(P)+ = a 2-hydroxycarbonyl compound + NAD(P)H + H+." [EC:1.1.1.185, MetaCyc:L-GLYCOL-DEHYDROGENASE-RXN]


id: GO:0050027
name: obsolete L-idonate 2-dehydrogenase activity
namespace: molecular_function
def:
  "OBSOLETE. Catalysis of the reaction: L-idonate + NADP+ = 5-dehydro-D-gluconate + NADPH." [EC:1.1.1.128, MetaCyc:L-IDONATE-2-DEHYDROGENASE-RXN]


id: GO:0050029
name: L-lysine oxidase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: L-lysine + H(2)O + O(2) = 6-amino-2-oxohexanoate + H(2)O(2) + NH(4)(+)." [EC:1.4.3.14, RHEA:14440]


id: GO:0050030
name: L-pipecolate dehydrogenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: L-pipecolate + acceptor = delta1-piperideine-6-carboxylate + reduced acceptor. Delta1-piperideine-6-carboxylate is also known as 2,3,4,5-tetrahydropyridine-2-carboxylate." [EC:1.5.99.3, MetaCyc:L-PIPECOLATE-DEHYDROGENASE-RXN]


id: GO:0050031
name: L-pipecolate oxidase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: L-pipecolate + O(2) = 2,3,4,5-tetrahydropyridine-2-carboxylate + H(2)O(2) + H(+). Delta1-piperideine-6-carboxylate is also known as 2,3,4,5-tetrahydropyridine-2-carboxylate." [EC:1.5.3.7, RHEA:11995]


id: GO:0050032
name: L-rhamnonate dehydratase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: L-rhamnonate = 2-dehydro-3-deoxy-L-rhamnonate + H(2)O." [EC:4.2.1.90, RHEA:23083]


id: GO:0050033
name: L-rhamnono-1,4-lactonase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: L-rhamnono-1,4-lactone + H(2)O = L-rhamnonate + H(+)." [EC:3.1.1.65, RHEA:10291]


id: GO:0050034
name: L-rhamnose 1-dehydrogenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: L-rhamnofuranose + NAD(+) = L-rhamnono-1,4-lactone + H(+) + NADH." [EC:1.1.1.173, RHEA:12652]


id: GO:0050035
name: L-sorbose oxidase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: L-sorbose + O(2) = 5-dehydro-D-fructose + H(2)O(2)." [EC:1.1.3.11, RHEA:17856]


id: GO:0050036
name: L-threonate 3-dehydrogenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: L-threonate + NAD(+) = 3-dehydro-L-threonate + H(+) + NADH." [EC:1.1.1.129, RHEA:23379]


id: GO:0050037
name: L-xylose 1-dehydrogenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: aldehydo-L-xylose + NADP(+) = L-xylono-1,4-lactone + H(+) + NADPH." [EC:1.1.1.113, RHEA:15792]


id: GO:0050038
name: L-xylulose reductase (NADP+) activity
namespace: molecular_function
def:
  "Catalysis of the reaction: NADP(+) + xylitol = L-xylulose + H(+) + NADPH." [EC:1.1.1.10, RHEA:17028]


id: GO:0050039
name: lactaldehyde reductase (NADPH) activity
namespace: molecular_function
def:
  "Catalysis of the reaction: NADP(+) + propane-1,2-diol = (S)-lactaldehyde + H(+) + NADPH." [EC:1.1.1.55, RHEA:15888]


id: GO:0050040
name: lactate 2-monooxygenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: (S)-lactate + O(2) = acetate + CO(2) + H(2)O." [EC:1.13.12.4, RHEA:16516]


id: GO:0050042
name: lactate-malate transhydrogenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: (S)-lactate + oxaloacetate = malate + pyruvate." [EC:1.1.99.7, RHEA:10987]


id: GO:0050044
name: galactose-6-phosphate isomerase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: D-galactose 6-phosphate = D-tagatose 6-phosphate." [EC:5.3.1.26, RHEA:13036]


id: GO:0050045
name: laminaribiose phosphorylase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 3-beta-D-glucosyl-D-glucose + phosphate = D-glucose + alpha-D-glucose 1-phosphate." [EC:2.4.1.31, MetaCyc:LAMINARIBIOSE-PHOSPHORYLASE-RXN]


id: GO:0050046
name: lathosterol oxidase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 5-alpha-cholest-7-en-3-beta-ol + O2 = cholesta-5,7-dien-3-beta-ol + H2O2." [EC:1.14.21.6, MetaCyc:LATHOSTEROL-OXIDASE-RXN]


id: GO:0050048
name: L-leucine:2-oxoglutarate aminotransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: L-leucine + 2-oxoglutarate = 4-methyl-2-oxopentanoate + L-glutamate." [EC:2.6.1.6, MetaCyc:LEUCINE-AMINOTRANSFERASE-RXN]


id: GO:0050049
name: leucine dehydrogenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: L-leucine + H2O + NAD+ = 4-methyl-2-oxopentanoate + NH3 + NADH." [EC:1.4.1.9, MetaCyc:LEUCINE-DEHYDROGENASE-RXN]


id: GO:0050050
name: leucine N-acetyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: L-leucine + acetyl-CoA = N-acetyl-L-leucine + CoA + H(+)." [EC:2.3.1.66, RHEA:20092]


id: GO:0050051
name: leukotriene-B4 20-monooxygenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: (6Z,8E,10E,14Z)-(5S,12R)-5,12-dihydroxyicosa-6,8,10,14-tetraenoate + NADPH + H+ + O2 = (6Z,8E,10E,14Z)-(5S,12R)-5,12,20-trihydroxyicosa-6,8,10,14-tetraenoate + NADP+ + H2O." [EC:1.14.13.30, MetaCyc:LEUKOTRIENE-B4-20-MONOOXYGENASE-RXN]


id: GO:0050052
name: leukotriene-E4 20-monooxygenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: H(+) + leukotriene E(4) + NADPH + O(2) = 20-hydroxy-leukotriene E(4) + H(2)O + NADP(+)." [EC:1.14.13.34, RHEA:24123]


id: GO:0050053
name: levansucrase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: sucrose + 2,6-beta-D-fructosyl(n) = glucose + 2,6-beta-D-fructosyl(n+1)." [EC:2.4.1.10, MetaCyc:LEVANSUCRASE-RXN]


id: GO:0050054
name: lignostilbene alpha beta-dioxygenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 1,2-bis(4-hydroxy-3-methoxyphenyl)ethylene + O(2) = 2 vanillin." [EC:1.13.11.43, RHEA:21343]


id: GO:0050055
name: limonin-D-ring-lactonase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: limonoate D-ring-lactone + H2O = limonoate." [EC:3.1.1.36, MetaCyc:LIMONIN-D-RING-LACTONASE-RXN]


id: GO:0050056
name: linalool 8-monooxygenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: AH(2) + linalool + O(2) = (2E)-2,6-dimethylocta-2,7-diene-1,6-diol + A + H(2)O." [EC:1.14.99.28, RHEA:20763]


id: GO:0050057
name: linamarin synthase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: UDP-glucose + 2-hydroxy-2-methylpropanenitrile = UDP + linamarin." [EC:2.4.1.63, MetaCyc:LINAMARIN-SYNTHASE-RXN]


id: GO:0050059
name: lombricine kinase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: ATP + lombricine = ADP + N-phospholombricine." [EC:2.7.3.5, MetaCyc:LOMBRICINE-KINASE-RXN]


id: GO:0050060
name: long-chain-alcohol dehydrogenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: a long-chain alcohol + 2 NAD+ + H2O = a long-chain carboxylate + 2 NADH." [EC:1.1.1.192, MetaCyc:LONG-CHAIN-ALCOHOL-DEHYDROGENASE-RXN]


id: GO:0050061
name: long-chain-aldehyde dehydrogenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: a long-chain aldehyde + NAD+ = a long-chain carboxylate + NADH + H+. A long-chain aldehyde is one with more than 12 carbons." [EC:1.2.1.48, MetaCyc:LONG-CHAIN-ALDEHYDE-DEHYDROGENASE-RXN]


id: GO:0050062
name: long-chain-fatty-acyl-CoA reductase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: a long-chain aldehyde + CoA + NADP+ = a long-chain acyl-CoA + NADPH." [EC:1.2.1.50, MetaCyc:LONG-CHAIN-FATTY-ACYL-COA-REDUCTASE-RXN]


id: GO:0050063
name: low-density-lipoprotein particle receptor kinase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: ATP + low-density lipoprotein L-serine = ADP + low-density lipoprotein O-phospho-L-serine." [EC:2.7.11.29, MetaCyc:LOW-DENSITY-LIPOPROTEIN-KINASE-RXN]


id: GO:0050064
name: luteolin 7-O-glucuronosyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: luteolin + UDP-alpha-D-glucuronate = luteolin 7-O-beta-D-glucosiduronate + UDP." [EC:2.4.1.189, RHEA:10571]


id: GO:0050065
name: lysine-pyruvate 6-transaminase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: L-lysine + pyruvate = L-alanine + L-allysine." [EC:2.6.1.71, RHEA:19396]


id: GO:0050067
name: lysine 2-monooxygenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: L-lysine + O(2) = 5-aminopentanamide + CO(2) + H(2)O." [EC:1.13.12.2, RHEA:14604]


id: GO:0050068
name: lysine carbamoyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: L-lysine + carbamoyl phosphate = L-homocitrulline + H(+) + phosphate." [EC:2.1.3.8, RHEA:17124]


id: GO:0050069
name: lysine dehydrogenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: L-lysine + NAD+ = 1,2-didehydropiperidine-2-carboxylate + NH3 + NADH." [EC:1.4.1.15, MetaCyc:LYSINE-DEHYDROGENASE-RXN]


id: GO:0050070
name: lysolecithin acylmutase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 1-acyl-sn-glycero-3-phosphocholine = 2-acyl-sn-glycero-3-phosphocholine." [EC:5.4.1.1, RHEA:24359]


id: GO:0050071
name: lysyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: L-lysyl-tRNA + phosphatidylglycerol = tRNA + 3-phosphatidyl-1'-(3'-O-L-lysyl)glycerol." [EC:2.3.2.3, MetaCyc:LYSYLTRANSFERASE-RXN]


id: GO:0050072
name: m7G(5')pppN diphosphatase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 7-methylguanosine 5'-triphospho-5'-polynucleotide + H2O = 7-methylguanosine 5'-phosphate + polynucleotide." [EC:3.6.1.30, MetaCyc:M7G5PPPN-PYROPHOSPHATASE-RXN]


id: GO:0050073
name: macrolide 2'-kinase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: ATP + oleandomycin = ADP + 2 H(+) + oleandomycin 2'-O-phosphate." [EC:2.7.1.136, RHEA:18336]


id: GO:0050074
name: malate-CoA ligase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: ATP + malate + CoA = ADP + phosphate + malyl-CoA." [EC:6.2.1.9, MetaCyc:MALATE--COA-LIGASE-RXN]


id: GO:0050077
name: maleylpyruvate isomerase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 3-maleylpyruvate = 3-fumarylpyruvate." [EC:5.2.1.4, MetaCyc:MALEYLPYRUVATE-ISOMERASE-RXN]


id: GO:0050078
name: malonate CoA-transferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: acetyl-CoA + malonate = acetate + malonyl-CoA." [EC:2.8.3.3, RHEA:18820]


id: GO:0050079
name: acetylenecarboxylate hydratase activity, producing 3-oxopropanoate
namespace: molecular_function
def:
  "Catalysis of the reaction: 3-oxopropanoate = propynoate + H2O." [EC:4.2.1.27, MetaCyc:MALONATE-SEMIALDEHYDE-DEHYDRATASE-RXN]


id: GO:0050080
name: malonyl-CoA decarboxylase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: malonyl-CoA = acetyl-CoA + CO2." [EC:4.1.1.9, MetaCyc:MALONYL-COA-DECARBOXYLASE-RXN]


id: GO:0050081
name: maltose-6'-phosphate glucosidase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: H2O + maltose 6'-phosphate = D-glucose + D-glucose 6-phosphate." [EC:3.2.1.122, MetaCyc:MALTOSE-6-PHOSPHATE-GLUCOSIDASE-RXN]


id: GO:0050082
name: maltose phosphorylase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: maltose + phosphate = D-glucose + beta-D-glucose 1-phosphate." [EC:2.4.1.8, MetaCyc:MALTOSE-PHOSPHORYLASE-RXN]


id: GO:0050083
name: malyl-CoA lyase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: (3S)-3-carboxy-3-hydroxypropanoyl-CoA = acetyl-CoA + glyoxylate." [EC:4.1.3.24, MetaCyc:MALYL-COA-LYASE-RXN]


id: GO:0050084
name: mannitol-1-phosphatase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: D-mannitol 1-phosphate + H(2)O = D-mannitol + 2 H(+) + phosphate." [EC:3.1.3.22, RHEA:19540]


id: GO:0050085
name: mannitol 2-dehydrogenase (NADP+) activity
namespace: molecular_function
def:
  "Catalysis of the reaction: D-mannitol + NADP(+) = D-fructose + H(+) + NADPH." [EC:1.1.1.138, RHEA:16768]


id: GO:0050086
name: mannitol 2-dehydrogenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: D-mannitol + NAD+ = D-fructose + NADH." [EC:1.1.1.67, MetaCyc:MANNITOL-2-DEHYDROGENASE-RXN]


id: GO:0050087
name: mannitol dehydrogenase (cytochrome) activity
namespace: molecular_function
def:
  "Catalysis of the reaction: D-mannitol + ferricytochrome c = D-fructose + ferrocytochrome c." [EC:1.1.2.2, MetaCyc:MANNITOL-DEHYDROGENASE-CYTOCHROME-RXN]


id: GO:0050088
name: mannose-6-phosphate 6-reductase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: D-mannitol 1-phosphate + NADP(+) = D-mannose 6-phosphate + 3 H(+) + NADPH." [EC:1.1.1.224, RHEA:14928]


id: GO:0050090
name: mannuronate reductase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: D-mannonate + NAD(P)+ = D-mannuronate + NAD(P)H + H+." [EC:1.1.1.131, MetaCyc:MANNURONATE-REDUCTASE-RXN]


id: GO:0050091
name: melilotate 3-monooxygenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 3-(2-hydroxyphenyl)propanoate + H(+) + NADH + O(2) = 3-(2,3-dihydroxyphenyl)propanoate + H(2)O + NAD(+)." [EC:1.14.13.4, RHEA:17672]


id: GO:0050092
name: meso-tartrate dehydrogenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: (2R,3S)-tartrate + NAD(+) = dihydroxyfumarate + H(+) + NADH." [EC:1.3.1.7, RHEA:18556]


id: GO:0050093
name: methanol dehydrogenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: methanol + NAD(+) = formaldehyde + H(+) + NADH." [EC:1.1.1.244, RHEA:19404]


id: GO:0050094
name: methionine-glyoxylate transaminase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: L-methionine + glyoxylate = 4-methylthio-2-oxobutanoate + glycine." [EC:2.6.1.73, RHEA:22887]


id: GO:0050095
name: methionine decarboxylase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: L-methionine + H(+) = 3-methylthiopropanamine + CO(2)." [EC:4.1.1.57, RHEA:17760]


id: GO:0050096
name: methylaspartate ammonia-lyase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: threo-3-methyl-L-aspartate = mesaconate + NH(4)(+)." [EC:4.3.1.2, RHEA:12832]


id: GO:0050098
name: methylguanidinase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: H(2)O + methylguanidine = methylammonium + urea." [EC:3.5.3.16, RHEA:11767]


id: GO:0050099
name: methylglutamate dehydrogenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: N-methyl-L-glutamate + A + H(2)O = L-glutamate + AH(2) + formaldehyde." [EC:1.5.99.5, RHEA:22575]


id: GO:0050100
name: methylitaconate delta-isomerase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 2-methylene-3-methylsuccinate = dimethylmaleate." [EC:5.3.3.6, RHEA:23483]


id: GO:0050101
name: mimosinase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: L-mimosine + H(2)O = 3-hydroxy-4H-pyrid-4-one + L-serine." [EC:3.5.1.61, RHEA:13376]


id: GO:0050102
name: cellodextrin phosphorylase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 1,4-beta-D-glucosyl(n) + phosphate = 1,4-beta-D-glucosyl(n-1) + alpha-D-glucose 1-phosphate." [EC:2.4.1.49, MetaCyc:CELLODEXTRIN-PHOSPHORYLASE-RXN]


id: GO:0050103
name: dextrin dextranase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 1,4-alpha-D-glucosyl(n) + 1,6-alpha-D-glucosyl(m) = 1,4-alpha-D-glucosyl(n-1) + 1,6-alpha-D-glucosyl(m+1)." [EC:2.4.1.2, MetaCyc:DEXTRIN-DEXTRANASE-RXN]


id: GO:0050104
name: L-gulonate 3-dehydrogenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: L-gulonate + NAD(+) = 3-dehydro-L-gulonate + H(+) + NADH." [EC:1.1.1.45, RHEA:12892]


id: GO:0050105
name: L-gulonolactone oxidase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: L-gulono-1,4-lactone + O2 = L-xylo-hex-3-ulonolactone + H2O2." [EC:1.1.3.8, MetaCyc:L-GULONOLACTONE-OXIDASE-RXN]


id: GO:0050106
name: monomethyl-sulfatase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: H(2)O + monomethyl sulfate = H(+) + methanol + sulfate." [EC:3.1.6.16, RHEA:14224]


id: GO:0050107
name: monoterpenol O-acetyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: acetyl-CoA + a monoterpenol = CoA + a monoterpenol acetate ester." [EC:2.3.1.69, MetaCyc:MONOTERPENOL-O-ACETYLTRANSFERASE-RXN]


id: GO:0050108
name: monoterpenyl-diphosphatase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: monoterpenyl diphosphate + H2O = monoterpenol + diphosphate." [EC:3.1.7.3, MetaCyc:MONOTERPENYL-PYROPHOSPHATASE-RXN]


id: GO:0050109
name: morphine 6-dehydrogenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: morphine + NAD(P)+ = morphinone + NAD(P)H + H+." [EC:1.1.1.218, MetaCyc:MORPHINE-6-DEHYDROGENASE-RXN]


id: GO:0050110
name: mucinaminylserine mucinaminidase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: D-galactosyl-3-(N-acetyl-beta-D-galactosaminyl)-L-serine + H2O = D-galactosyl-3-N-acetyl-beta-D-galactosamine + L-serine." [MetaCyc:3.2.1.110-RXN]


id: GO:0050111
name: mycocerosate synthase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: acyl-CoA + 7n H(+) + n methylmalonyl-CoA + 2n NADPH = n CO(2) + n CoA + n H(2)O + multi-methyl-branched acyl-CoA + 2n NADP(+)." [EC:2.3.1.111, RHEA:10591]


id: GO:0050112
name: inositol 2-dehydrogenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: myo-inositol + NAD(+) = 2,4,6/3,5-pentahydroxycyclohexanone + H(+) + NADH." [EC:1.1.1.18, RHEA:16952]


id: GO:0050113
name: inositol oxygenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: myo-inositol + O(2) = D-glucuronate + H(2)O + H(+)." [EC:1.13.99.1, RHEA:23699]


id: GO:0050114
name: myo-inosose-2 dehydratase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 2,4,6/3,5-pentahydroxycyclohexanone = 3D-3,5/4-trihydroxycyclohexane-1,2-dione + H(2)O." [EC:4.2.1.44, RHEA:14068]


id: GO:0050115
name: myosin-light-chain-phosphatase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: myosin light-chain phosphate + H2O = myosin light chain + phosphate." [EC:3.1.3.53, MetaCyc:MYOSIN-LIGHT-CHAIN-PHOSPHATASE-RXN]


id: GO:0050116
name: N,N-dimethylformamidase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: N,N-dimethylformamide + H(2)O = dimethylamine + formate." [EC:3.5.1.56, RHEA:19520]


id: GO:0050117
name: N-acetyl-beta-alanine deacetylase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: N-acetyl-beta-alanine + H(2)O = beta-alanine + acetate." [EC:3.5.1.21, RHEA:23215]


id: GO:0050118
name: N-acetyldiaminopimelate deacetylase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: N-acetyl-LL-2,6-diaminopimelate + H(2)O = LL-2,6-diaminopimelate + acetate." [EC:3.5.1.47, RHEA:20408]


id: GO:0050119
name: N-acetylglucosamine deacetylase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: N-acetyl-D-glucosamine + H(2)O = D-glucosamine + acetate." [EC:3.5.1.33, RHEA:20596]


id: GO:0050120
name: N-acetylhexosamine 1-dehydrogenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: N-acetyl-D-glucosamine + H(2)O + NAD(+) = N-acetyl-D-glucosaminate + 2 H(+) + NADH." [EC:1.1.1.240, RHEA:23147]


id: GO:0050121
name: N-acylglucosamine 2-epimerase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: N-acyl-D-glucosamine = N-acyl-D-mannosamine." [EC:5.1.3.8, MetaCyc:N-ACYLGLUCOSAMINE-2-EPIMERASE-RXN]


id: GO:0050122
name: N-acylhexosamine oxidase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: N-acetyl-D-glucosamine + H(2)O + O(2) = N-acetyl-D-glucosaminate + H(2)O(2) + H(+)." [EC:1.1.3.29, RHEA:13032]


id: GO:0050123
name: N-acylmannosamine 1-dehydrogenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: N-acyl-D-mannosamine + NAD(+) = N-acyl-D-mannosaminolactone + H(+) + NADH." [EC:1.1.1.233, RHEA:11543]


id: GO:0050124
name: N-acylneuraminate-9-phosphatase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: N-acylneuraminate 9-phosphate + H2O = N-acylneuraminate + phosphate." [EC:3.1.3.29, MetaCyc:N-ACYLNEURAMINATE-9-PHOSPHATASE-RXN]


id: GO:0050125
name: N-benzyloxycarbonylglycine hydrolase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: N-benzyloxycarbonylglycine + H(2)O + H(+) = benzyl alcohol + CO(2) + glycine." [EC:3.5.1.58, RHEA:20903]


id: GO:0050126
name: N-carbamoylputrescine amidase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: N-carbamoylputrescine + H(2)O + 2 H(+) = CO(2) + NH(4)(+) + putrescine." [EC:3.5.1.53, RHEA:22287]


id: GO:0050127
name: N-carbamoylsarcosine amidase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: N-carbamoylsarcosine + H(2)O + 2 H(+) = CO(2) + NH(4)(+) + sarcosine." [EC:3.5.1.59, RHEA:20060]


id: GO:0050128
name: N-feruloylglycine deacylase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: N-feruloylglycine + H(2)O = ferulate + glycine." [EC:3.5.1.71, RHEA:10487]


id: GO:0050129
name: N-formylglutamate deformylase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: N-formyl-L-glutamate + H(2)O = L-glutamate + formate." [EC:3.5.1.68, RHEA:12479]


id: GO:0050130
name: N-methyl-2-oxoglutaramate hydrolase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: N-methyl-2-oxoglutaramate + H(2)O = 2-oxoglutarate + methylammonium." [EC:3.5.1.36, RHEA:24111]


id: GO:0050131
name: N-methyl-L-amino-acid oxidase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: an N-methyl-L-amino acid + H2O + O2 = an L-amino acid + formaldehyde + H2O2." [EC:1.5.3.2, MetaCyc:N-METHYL-L-AMINO-ACID-OXIDASE-RXN]


id: GO:0050132
name: N-methylalanine dehydrogenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: N-methyl-L-alanine + H(2)O + NADP(+) = H(+) + methylammonium + NADPH + pyruvate." [EC:1.4.1.17, RHEA:21771]


id: GO:0050133
name: N6-hydroxylysine O-acetyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: N(6)-hydroxy-L-lysine + acetyl-CoA = N(6)-acetyl-N(6)-hydroxy-L-lysine + CoA." [EC:2.3.1.102, RHEA:22391]


id: GO:0050134
name: N6-methyl-lysine oxidase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: N(6)-methyl-L-lysine + H(2)O + O(2) = L-lysine + formaldehyde + H(2)O(2)." [EC:1.5.3.4, RHEA:23203]


id: GO:0050135
name: NAD(P)+ nucleosidase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: NAD(P)+ + H2O = ADP-ribose(P) + nicotinamide." [EC:3.2.2.6, MetaCyc:NADP+-NUCLEOSIDASE-RXN]


id: GO:0050136
name: NADH dehydrogenase (quinone) activity
namespace: molecular_function
def:
  "Catalysis of the reaction: NADH + H+ + a quinone = NAD+ + a quinol." [EC:1.6.99.5, GOC:mah, MetaCyc:NADH-DEHYDROGENASE-QUINONE-RXN]


id: GO:0050138
name: nicotinate dehydrogenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: H(2)O + NADP(+) + nicotinate = 6-hydroxynicotinate + H(+) + NADPH." [EC:1.17.1.5, RHEA:12239]


id: GO:0050139
name: nicotinate glucosyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: nicotinate + UDP-D-glucose = N-(beta-D-glucosyl)nicotinate + UDP." [EC:2.4.1.196, RHEA:19440]


id: GO:0050140
name: nitrate reductase (cytochrome) activity
namespace: molecular_function
def:
  "Catalysis of the reaction: ferrocytochrome + nitrate = ferricytochrome + nitrite." [EC:1.9.6.1, MetaCyc:NITRATE-REDUCTASE-CYTOCHROME-RXN]


id: GO:0050141
name: nitroethane oxidase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: nitroethane + H2O + O2 = acetaldehyde + nitrite + H2O2." [EC:1.7.3.1, MetaCyc:NITROETHANE-OXIDASE-RXN]


id: GO:0050142
name: nitrogenase (flavodoxin) activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 6 reduced flavodoxin + 6 H+ + N2 + n ATP = 6 oxidized flavodoxin + 2 NH3 + n ADP + n phosphate." [EC:1.19.6.1, MetaCyc:NITROGENASE-FLAVODOXIN-RXN]


id: GO:0050144
name: nucleoside deoxyribosyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 2-deoxy-D-ribosyl-base1 + base2 = 2-deoxy-D-ribosyl-base2 + base1." [EC:2.4.2.6, MetaCyc:NUCLEOSIDE-DEOXYRIBOSYLTRANSFERASE-RXN]


id: GO:0050145
name: nucleoside phosphate kinase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: ATP + nucleoside phosphate = ADP + nucleoside diphosphate." [EC:2.7.4.4, MetaCyc:NUCLEOSIDE-PHOSPHATE-KINASE-RXN]


id: GO:0050146
name: nucleoside phosphotransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: a nucleotide + a 2'-deoxynucleoside = a nucleoside + a 2'-deoxynucleoside 5'-monophosphate." [EC:2.7.1.77, MetaCyc:NUCLEOSIDE-PHOSPHOTRANSFERASE-RXN]


id: GO:0050147
name: nucleoside ribosyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: D-ribosyl-base1 + base2 = D-ribosyl-base2 + base1." [EC:2.4.2.5, MetaCyc:NUCLEOSIDE-RIBOSYLTRANSFERASE-RXN]


id: GO:0050148
name: nucleotide diphosphokinase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: ATP + nucleoside 5'-phosphate = AMP + 5'-phosphonucleoside 3'-diphosphate." [EC:2.7.6.4, MetaCyc:NUCLEOTIDE-PYROPHOSPHOKINASE-RXN]


id: GO:0050149
name: o-aminophenol oxidase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 2 2-aminophenol + 3 O2 = 2 isophenoxazine + 6 H2O." [EC:1.10.3.4, MetaCyc:O-AMINOPHENOL-OXIDASE-RXN]


id: GO:0050150
name: o-pyrocatechuate decarboxylase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 2,3-dihydroxybenzoate + H(+) = catechol + CO(2)." [EC:4.1.1.46, RHEA:21495]


id: GO:0050152
name: omega-amidase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: a monoamide of a dicarboxylic acid + H2O = a dicarboxylate + NH3." [EC:3.5.1.3, MetaCyc:OMEGA-AMIDASE-RXN]


id: GO:0050153
name: omega-hydroxydecanoate dehydrogenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 10-hydroxydecanoate + NAD(+) = 10-oxodecanoate + H(+) + NADH." [EC:1.1.1.66, RHEA:20883]


id: GO:0050154
name: opheline kinase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: ATP + guanidinoethyl methyl phosphate = N'-phosphoguanidinoethyl methylphosphate + ADP + 2 H(+)." [EC:2.7.3.7, RHEA:17556]


id: GO:0050155
name: ornithine(lysine) transaminase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 2-oxoglutarate + L-ornithine = H2O + L-glutamate + 3,4-dihydro-2H-pyrrole-2-carboxylate." [EC:2.6.1.68, MetaCyc:ORNITHINELYSINE-AMINOTRANSFERASE-RXN]


id: GO:0050156
name: ornithine N-benzoyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: L-ornithine + 2 benzoyl-CoA = N(2),N(5)-dibenzoyl-L-ornithine + 2 CoA + 2 H(+)." [EC:2.3.1.127, RHEA:16932]


id: GO:0050157
name: ornithine racemase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: L-ornithine = D-ornithine." [EC:5.1.1.12, MetaCyc:ORNITHINE-RACEMASE-RXN]


id: GO:0050158
name: orotate reductase (NADPH) activity
namespace: molecular_function
def:
  "Catalysis of the reaction: (S)-dihydroorotate + NADP(+) = H(+) + NADPH + orotate." [EC:1.3.1.15, RHEA:14864]


id: GO:0050160
name: orsellinate-depside hydrolase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: H(2)O + orsellinate depside = 2 o-orsellinate + H(+)." [EC:3.1.1.40, RHEA:19552]


id: GO:0050161
name: succinyl-CoA:oxalate CoA-transferase
namespace: molecular_function
def:
  "Catalysis of the reaction: oxalate + succinyl-CoA = oxalyl-CoA + succinate." [EC:2.8.3.2, RHEA:23591]


id: GO:0050163
name: oxaloacetate tautomerase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: oxaloacetate = <stereo>enol</stereo>-oxaloacetate." [EC:5.3.2.2, RHEA:16024]


id: GO:0050164
name: oxoglutarate dehydrogenase (NADP+) activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 2-oxoglutarate + CoA + NADP(+) = CO(2) + NADPH + succinyl-CoA." [EC:1.2.1.52, RHEA:21403]


id: GO:0050165
name: pantetheine kinase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: ATP + pantetheine = ADP + pantetheine 4'-phosphate." [EC:2.7.1.34, MetaCyc:PANTETHEINE-KINASE-RXN]


id: GO:0050166
name: pantoate 4-dehydrogenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: (R)-pantoate + NAD(+) = (R)-4-dehydropantoate + H(+) + NADH." [EC:1.1.1.106, RHEA:23003]


id: GO:0050167
name: pantothenoylcysteine decarboxylase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: N-[(R)-pantothenoyl]-L-cysteine + H(+) = (R)-pantetheine + CO(2)." [EC:4.1.1.30, RHEA:15080]


id: GO:0050169
name: peptide-tryptophan 2,3-dioxygenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: peptide tryptophan + O2 = peptide formylkynurenine." [EC:1.13.11.26, MetaCyc:PEPTIDE-TRYPTOPHAN-23-DIOXYGENASE-RXN]


id: GO:0050170
name: peptidyl-glutaminase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: alpha-N-peptidyl-L-glutamine + H2O = alpha-N-peptidyl-L-glutamate + NH3." [EC:3.5.1.43, MetaCyc:PEPTIDYL-GLUTAMINASE-RXN]


id: GO:0050171
name: phenol beta-glucosyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: UDP-glucose + a phenol = UDP + an aryl beta-D-glucoside." [EC:2.4.1.35, MetaCyc:PHENOL-BETA-GLUCOSYLTRANSFERASE-RXN]


id: GO:0050172
name: phenylalanine 2-monooxygenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: L-phenylalanine + O(2) = 2-phenylacetamide + CO(2) + H(2)O." [EC:1.13.12.9, RHEA:10715]


id: GO:0050173
name: phenylalanine adenylyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: L-phenylalanine + ATP = N-adenylyl-L-phenylalanine + diphosphate + 2 H(+)." [EC:2.7.7.54, RHEA:17192]


id: GO:0050174
name: phenylalanine decarboxylase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: L-phenylalanine = phenylethylamine + CO2." [EC:4.1.1.53, MetaCyc:PHENYLALANINE-DECARBOXYLASE-RXN]


id: GO:0050175
name: phenylalanine dehydrogenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: L-phenylalanine + H2O + NAD+ = phenylpyruvate + NH3 + NADH." [EC:1.4.1.20, MetaCyc:PHENYLALANINE-DEHYDROGENASE-RXN]


id: GO:0050176
name: phenylalanine N-acetyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: L-phenylalanine + acetyl-CoA = N-acetyl-L-phenylalanine + CoA + H(+)." [EC:2.3.1.53, RHEA:17804]


id: GO:0050177
name: phenylpyruvate decarboxylase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: phenylpyruvate = phenylacetaldehyde + CO2." [EC:4.1.1.43, MetaCyc:PHENYLPYRUVATE-DECARBOXYLASE-RXN]


id: GO:0050178
name: phenylpyruvate tautomerase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: keto-phenylpyruvate = enol-phenylpyruvate." [EC:5.3.2.1, MetaCyc:PHENYLPYRUVATE-TAUTOMERASE-RXN]


id: GO:0050179
name: phenylserine aldolase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: L-threo-3-phenylserine = benzaldehyde + glycine." [EC:4.1.2.26, RHEA:21715]


id: GO:0050180
name: phloretin hydrolase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: H(2)O + phloretin = H(+) + phloretate + phloroglucinol." [EC:3.7.1.4, RHEA:23399]


id: GO:0050181
name: phorbol-diester hydrolase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: H(2)O + phorbol 12,13-dibutanoate = butanoate + H(+) + phorbol 13-butanoate." [EC:3.1.1.51, RHEA:21319]


id: GO:0050182
name: phosphate butyryltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: butanoyl-CoA + phosphate = butanoyl phosphate + CoA." [EC:2.3.1.19, RHEA:20895]


id: GO:0050183
name: phosphatidylcholine 12-monooxygenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 1-acyl-2-oleoyl-sn-glycero-3-phosphocholine + H(+) + NADH + O(2) = 1-acyl-2-[(S)-12-hydroxyoleoyl]-sn-glycero-3-phosphocholine + H(2)O + NAD(+)." [EC:1.14.13.26, RHEA:11371]


id: GO:0050184
name: phosphatidylcholine desaturase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 1-acyl-2-oleoyl-sn-glycero-3-phosphocholine + NAD(+) = 1-acyl-2-linoleoyl-sn-glycero-3-phosphocholine + H(+) + NADH." [EC:1.3.1.35, RHEA:12567]


id: GO:0050185
name: phosphatidylinositol deacylase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol + H(2)O = 1-acyl-sn-glycero-3-phospho-D-myo-inositol + a carboxylate + H(+)." [EC:3.1.1.52, RHEA:18004]


id: GO:0050186
name: phosphoadenylylsulfatase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + H2O = adenosine 3',5'-bisphosphate + sulfate." [EC:3.6.2.2, MetaCyc:PHOSPHOADENYLYLSULFATASE-RXN]


id: GO:0050187
name: phosphoamidase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: N-phosphocreatine + H(2)O = creatine + phosphate." [EC:3.9.1.1, RHEA:12980]


id: GO:0050189
name: phosphoenolpyruvate phosphatase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: H(2)O + phosphoenolpyruvate = phosphate + pyruvate." [EC:3.1.3.60, RHEA:20000]


id: GO:0050190
name: phosphoglucokinase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: alpha-D-glucose 1-phosphate + ATP = alpha-D-glucose 1,6-bisphosphate + ADP + 2 H(+)." [EC:2.7.1.10, RHEA:13380]


id: GO:0050191
name: phosphoglycerate kinase (GTP) activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 3-phospho-D-glycerate + GTP = 3-phospho-D-glyceroyl phosphate + GDP + H(+)." [EC:2.7.2.10, RHEA:23335]


id: GO:0050192
name: phosphoglycerate phosphatase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 2-phospho-D-glycerate + H(2)O = D-glycerate + phosphate." [EC:3.1.3.20, RHEA:21159]


id: GO:0050193
name: phosphoketolase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: D-xylulose 5-phosphate + phosphate = acetyl phosphate + D-glyceraldehyde 3-phosphate + H2O." [EC:4.1.2.9, MetaCyc:PHOSPHOKETOLASE-RXN]


id: GO:0050194
name: phosphonoacetaldehyde hydrolase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: H(2)O + phosphonoacetaldehyde = acetaldehyde + H(+) + phosphate." [EC:3.11.1.1, RHEA:18908]


id: GO:0050195
name: phosphoribokinase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: D-ribose 5-phosphate + ATP = D-ribose 1,5-diphosphate + ADP + 2 H(+)." [EC:2.7.1.18, RHEA:21219]


id: GO:0050196
name: [phosphorylase] phosphatase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: [phosphorylase a] + 4 H2O = 2 [phosphorylase b] + 4 phosphate." [EC:3.1.3.17, MetaCyc:PHOSPHORYLASE-PHOSPHATASE-RXN]


id: GO:0050197
name: phytanate-CoA ligase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: ATP + CoA + phytanate = AMP + diphosphate + H(+) + phytanoyl-CoA." [EC:6.2.1.24, RHEA:21383]


id: GO:0050198
name: pinosylvin synthase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: trans-cinnamoyl-CoA + 3 H(+) + 3 malonyl-CoA = 4 CO(2) + 4 CoA + pinosylvin." [EC:2.3.1.146, RHEA:12555]


id: GO:0050199
name: piperidine N-piperoyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: (E,E)-piperoyl-CoA + piperidine = N-[(E,E)-piperoyl]piperidine + CoA + H(+)." [EC:2.3.1.145, RHEA:14564]


id: GO:0050200
name: plasmalogen synthase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: acyl-CoA + 1-O-alk-1-enyl-glycero-3-phosphocholine = CoA + plasmenylcholine." [EC:2.3.1.25, MetaCyc:PLASMALOGEN-SYNTHASE-RXN]


id: GO:0050201
name: fucokinase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: L-fucose + ATP = beta-L-fucose 1-phosphate + ADP + 2 H(+)." [EC:2.7.1.52, RHEA:13244]


id: GO:0050202
name: octopamine dehydratase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 1-(4-hydroxyphenyl)-2-aminoethanol = (4-hydroxyphenyl)acetaldehyde + NH(4)(+)." [EC:4.2.1.87, RHEA:18176]


id: GO:0050203
name: oxalate-CoA ligase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: ATP + CoA + oxalate = AMP + diphosphate + H(+) + oxalyl-CoA." [EC:6.2.1.8, RHEA:18296]


id: GO:0050205
name: oxamate carbamoyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: carbamoyl phosphate + oxamate = oxalurate + phosphate." [EC:2.1.3.5, RHEA:22987]


id: GO:0050206
name: oximinotransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 2-(hydroxyimino)propanoate + acetone = acetone oxime + pyruvate." [EC:2.6.3.1, RHEA:11627]


id: GO:0050207
name: plasmanylethanolamine desaturase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: O-1-alkyl-2-acyl-sn-glycero-3-phosphoethanolamine + donor-H2 + O2 = O-1-alk-1-enyl-2-acyl-sn-glycero-3-phosphoethanolamine + acceptor + 2 H2O." [EC:1.14.99.19, MetaCyc:PLASMANYLETHANOLAMINE-DESATURASE-RXN]


id: GO:0050208
name: polysialic-acid O-acetyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: acetyl-CoA + an alpha-2,8-linked polymer of sialic acid = CoA + polysialic acid acetylated at O-7 or O-9." [EC:2.3.1.136, MetaCyc:POLYSIALIC-ACID-O-ACETYLTRANSFERASE-RXN]


id: GO:0050209
name: polyvinyl-alcohol oxidase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: polyvinyl alcohol + O2 = oxidized polyvinyl alcohol + H2O2." [EC:1.1.3.30, MetaCyc:POLYVINYL-ALCOHOL-OXIDASE-RXN]


id: GO:0050210
name: prenyl-diphosphatase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: prenyl diphosphate + H2O = prenol + diphosphate." [EC:3.1.7.1, MetaCyc:PRENYL-PYROPHOSPHATASE-RXN]


id: GO:0050211
name: procollagen galactosyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: UDP-galactose + procollagen 5-hydroxy-L-lysine = UDP + procollagen 5-(D-galactosyloxy)-L-lysine." [EC:2.4.1.50, MetaCyc:PROCOLLAGEN-GALACTOSYLTRANSFERASE-RXN]


id: GO:0050212
name: progesterone 11-alpha-monooxygenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: AH(2) + O(2) + progesterone = 11alpha-hydroxyprogesterone + A + H(2)O." [EC:1.14.99.14, RHEA:18208]


id: GO:0050213
name: progesterone 5-alpha-reductase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 5-alpha-pregnan-3,20-dione + NADP+ = progesterone + NADPH." [EC:1.3.1.30, MetaCyc:PROGESTERONE-5-ALPHA-REDUCTASE-RXN]


id: GO:0050214
name: progesterone monooxygenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: AH(2) + O(2) + progesterone = A + H(2)O + testosterone acetate." [EC:1.14.99.4, RHEA:11987]


id: GO:0050216
name: propanediol-phosphate dehydrogenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: NAD(+) + propane-1,2-diol 1-phosphate = H(+) + hydroxyacetone phosphate + NADH." [EC:1.1.1.7, RHEA:21587]


id: GO:0050218
name: propionate-CoA ligase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: ATP + propanoate + CoA = AMP + diphosphate + propanoyl-CoA." [EC:6.2.1.17, MetaCyc:PROPIONATE--COA-LIGASE-RXN]


id: GO:0050221
name: prostaglandin-E2 9-reductase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: (5Z,13E)-(15S)-9-alpha,11-alpha,15-trihydroxyprosta-5,13-dienoate + NADP+ = (5Z,13E)-(15S)-11-alpha,15-dihydroxy-9-oxoprosta-5,13-dienoate + NADPH." [EC:1.1.1.189, MetaCyc:PROSTAGLANDIN-E2-9-REDUCTASE-RXN]


id: GO:0050223
name: protocatechuate decarboxylase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 3,4-dihydroxybenzoate + H(+) = catechol + CO(2)." [EC:4.1.1.63, RHEA:22419]


id: GO:0050224
name: prunasin beta-glucosidase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: (R)-prunasin + H(2)O = D-glucose + mandelonitrile." [EC:3.2.1.118, RHEA:16492]


id: GO:0050225
name: pseudouridine kinase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: ATP + pseudouridine = ADP + 2 H(+) + pseudouridine 5'-phosphate." [EC:2.7.1.83, RHEA:22451]


id: GO:0050226
name: psychosine sulfotransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + galactosylsphingosine = adenosine 3',5'-bisphosphate + psychosine sulfate." [EC:2.8.2.13, MetaCyc:PSYCHOSINE-SULFOTRANSFERASE-RXN]


id: GO:0050227
name: pteridine oxidase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 2-amino-4-hydroxypteridine + O2 = 2-amino-4,7-dihydroxypteridine + unknown." [EC:1.17.3.1, MetaCyc:PTERIDINE-OXIDASE-RXN]


id: GO:0050228
name: pterin deaminase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 2-amino-4-hydroxypteridine + H2O = 2,4-dihydroxypteridine + NH3." [EC:3.5.4.11, MetaCyc:PTERIN-DEAMINASE-RXN]


id: GO:0050229
name: pterocarpin synthase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: medicarpin + NADP+ = vestitone + NADPH." [EC:1.1.1.246, MetaCyc:PTEROCARPIN-SYNTHASE-RXN]


id: GO:0050230
name: purine imidazole-ring cyclase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: DNA 4,6-diamino-5-formamidopyrimidine = DNA adenine + H2O." [EC:4.3.2.4, MetaCyc:PURINE-IMIDAZOLE-RING-CYCLASE-RXN]


id: GO:0050231
name: putrescine carbamoyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: carbamoyl phosphate + putrescine = N-carbamoylputrescine + H(+) + phosphate." [EC:2.1.3.6, RHEA:21939]


id: GO:0050232
name: putrescine oxidase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: putrescine + O2 + H2O = 4-aminobutanal + NH3 + H2O2." [EC:1.4.3.10, MetaCyc:PUTRESCINE-OXIDASE-RXN]


id: GO:0050233
name: pyranose oxidase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: D-glucose + O(2) = 2-dehydro-D-glucose + H(2)O(2)." [EC:1.1.3.10, RHEA:10555]


id: GO:0050234
name: pyrazolylalanine synthase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: L-serine + pyrazole = 3-(pyrazol-1-yl)-L-alanine + H(2)O." [EC:4.2.1.50, RHEA:24515]


id: GO:0050235
name: pyridoxal 4-dehydrogenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: NAD(+) + pyridoxal = 4-pyridoxolactone + H(+) + NADH." [EC:1.1.1.107, RHEA:21339]


id: GO:0050236
name: pyridoxine:NADP 4-dehydrogenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: NADP(+) + pyridoxine = H(+) + NADPH + pyridoxal." [EC:1.1.1.65, RHEA:16132]


id: GO:0050237
name: pyridoxine 4-oxidase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: pyridoxine + O2 = pyridoxal + H2O2." [EC:1.1.3.12, MetaCyc:PYRIDOXINE-4-OXIDASE-RXN]


id: GO:0050238
name: pyridoxine 5-dehydrogenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: pyridoxine + acceptor = isopyridoxal + reduced acceptor." [EC:1.1.99.9, MetaCyc:PYRIDOXINE-5-DEHYDROGENASE-RXN]


id: GO:0050239
name: pyrithiamine deaminase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 1-(4-amino-2-methylpyrimid-5-ylmethyl)-3-(beta-hydroxyethyl)-2-methylpyridinium bromide + H2O = 1-(4-hydroxy-2-methylpyrimid-5-ylmethyl)-3-(beta-hydroxyethyl)-2-methylpyridinium bromide + NH3." [EC:3.5.4.20, MetaCyc:PYRITHIAMIN-DEAMINASE-RXN]


id: GO:0050240
name: pyrogallol 1,2-oxygenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: O(2) + pyrogallol = (Z)-5-oxohex-2-enedioate + 2 H(+)." [EC:1.13.11.35, RHEA:19676]


id: GO:0050241
name: pyrroline-2-carboxylate reductase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: L-proline + NAD(P)+ = 1-pyrroline-2-carboxylate + NAD(P)H + H+." [EC:1.5.1.1, MetaCyc:PYRROLINE-2-CARBOXYLATE-REDUCTASE-RXN]


id: GO:0050242
name: pyruvate, phosphate dikinase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: ATP + phosphate + pyruvate = AMP + diphosphate + 2 H(+) + phosphoenolpyruvate." [EC:2.7.9.1, RHEA:10759]


id: GO:0050243
name: pyruvate dehydrogenase (NADP+) activity
namespace: molecular_function
def:
  "Catalysis of the reaction: CoA + NADP(+) + pyruvate = acetyl-CoA + CO(2) + NADPH." [EC:1.2.1.51, RHEA:17428]


id: GO:0050244
name: pyruvate oxidase (CoA-acetylating) activity
namespace: molecular_function
def:
  "Catalysis of the reaction: CoA + H(+) + O(2) + pyruvate = acetyl-CoA + CO(2) + H(2)O(2)." [EC:1.2.3.6, RHEA:21915]


id: GO:0050246
name: questin monooxygenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: H(+) + NADPH + O(2) + questin = demethylsulochrin + NADP(+)." [EC:1.14.13.43, RHEA:10839]


id: GO:0050247
name: raucaffricine beta-glucosidase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: H(2)O + raucaffricine = D-glucose + vomilenine." [EC:3.2.1.125, RHEA:14560]


id: GO:0050248
name: Renilla-luciferin 2-monooxygenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: Renilla luciferin + O2 = oxidized Renilla luciferin + CO2 + light." [EC:1.13.12.5, MetaCyc:RENILLA-LUCIFERIN-2-MONOOXYGENASE-RXN]


id: GO:0050249
name: Renilla-luciferin sulfotransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 3'-phospho-5'-adenylyl sulfate + Renilla luciferin = adenosine 3',5'-diphosphate + H(+) + luciferyl sulfate." [EC:2.8.2.10, RHEA:20484]


id: GO:0050250
name: retinal oxidase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: retinal + O2 + H2O = retinoate + H2O2." [EC:1.2.3.11, MetaCyc:RETINAL-OXIDASE-RXN]


id: GO:0050252
name: retinol O-fatty-acyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: acyl-CoA + retinol = CoA + retinyl ester." [EC:2.3.1.76, MetaCyc:RETINOL-O-FATTY-ACYLTRANSFERASE-RXN]


id: GO:0050253
name: retinyl-palmitate esterase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: retinyl palmitate + H2O = retinol + palmitate + H+." [MetaCyc:RETINYL-PALMITATE-ESTERASE-RXN, RHEA:21511]


id: GO:0050254
name: rhodopsin kinase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: ATP + rhodopsin = ADP + phosphorhodopsin." [EC:2.7.11.14, MetaCyc:RHODOPSIN-KINASE-RXN]


id: GO:0050255
name: ribitol 2-dehydrogenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: D-ribitol + NAD(+) = D-ribulose + H(+) + NADH." [EC:1.1.1.56, RHEA:20056]


id: GO:0050256
name: ribitol-5-phosphate 2-dehydrogenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: D-ribitol 5-phosphate + NAD(P)+ = D-ribulose 5-phosphate + NAD(P)H + H+." [EC:1.1.1.137, MetaCyc:RIBITOL-5-PHOSPHATE-2-DEHYDROGENASE-RXN]


id: GO:0050257
name: riboflavin phosphotransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: alpha-D-glucose 1-phosphate + riboflavin = D-glucose + FMN." [EC:2.7.1.42, RHEA:20412]


id: GO:0050258
name: riboflavinase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: H(2)O + H(+) + riboflavin = D-ribitol + lumichrome." [EC:3.5.99.1, RHEA:11411]


id: GO:0050259
name: ribose 1-dehydrogenase (NADP+) activity
namespace: molecular_function
def:
  "Catalysis of the reaction: H(2)O + NADP(+) + ribofuranose = D-ribonate + 2 H(+) + NADPH." [EC:1.1.1.115, RHEA:11679]


id: GO:0050260
name: ribose-5-phosphate-ammonia ligase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: D-ribose 5-phosphate + ATP + NH(4)(+) = 5-phospho-D-ribosylamine + ADP + 2 H(+) + phosphate." [EC:6.3.4.7, RHEA:13780]


id: GO:0050262
name: ribosylnicotinamide kinase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: N-ribosylnicotinamide + ATP = ADP + 2 H(+) + nicotinamide mononucleotide." [EC:2.7.1.22, RHEA:14020]


id: GO:0050263
name: ribosylpyrimidine nucleosidase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: an N-D-ribosylpyrimidine + H2O = D-ribose + a pyrimidine." [EC:3.2.2.8, MetaCyc:RIBOSYLPYRIMIDINE-NUCLEOSIDASE-RXN]


id: GO:0050264
name: rifamycin-B oxidase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 2 H(+) + O(2) + rifamycin B = H(2)O(2) + rifamycin O." [EC:1.10.3.6, RHEA:11295]


id: GO:0050265
name: RNA uridylyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: UTP + RNA(n) = diphosphate + RNA(n+1)." [EC:2.7.7.52, MetaCyc:RNA-URIDYLYLTRANSFERASE-RXN]


id: GO:0050266
name: rosmarinate synthase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: caffeoyl-CoA + 3-(3,4-dihydroxyphenyl)lactate = CoA + rosmarinate." [EC:2.3.1.140, MetaCyc:ROSMARINATE-SYNTHASE-RXN]


id: GO:0050267
name: rubber cis-polyprenylcistransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: poly-cis-polyprenyl diphosphate + isopentenyl diphosphate = diphosphate + a poly-cis-polyprenyl diphosphate longer by one C5 unit." [EC:2.5.1.20, MetaCyc:RUBBER-CIS-POLYPRENYLCISTRANSFERASE-RXN]


id: GO:0050268
name: coniferyl-alcohol dehydrogenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: coniferyl alcohol + NADP+ = coniferyl aldehyde + NADPH." [EC:1.1.1.194, MetaCyc:RXN-1107]


id: GO:0050269
name: coniferyl-aldehyde dehydrogenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: coniferyl aldehyde + H2O + NAD(P)+ = ferulate + NAD(P)H + H+." [EC:1.2.1.68, MetaCyc:RXN-1241]


id: GO:0050270
name: S-adenosylhomocysteine deaminase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: S-adenosyl-L-homocysteine + H(2)O + H(+) = S-inosyl-L-homocysteine + NH(4)(+)." [EC:3.5.4.28, RHEA:20719]


id: GO:0050271
name: S-alkylcysteine lyase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: an S-alkyl-L-cysteine + H2O = an alkyl thiol + NH3 + pyruvate." [EC:4.4.1.6, MetaCyc:S-ALKYLCYSTEINE-LYASE-RXN]


id: GO:0050272
name: S-carboxymethylcysteine synthase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 3-chloro-L-alanine + thioglycolate = S-carboxymethyl-L-cysteine + chloride + H(+)." [EC:4.5.1.5, RHEA:22871]


id: GO:0050273
name: S-succinylglutathione hydrolase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: S-succinylglutathione + H(2)O = glutathione + H(+) + succinate." [EC:3.1.2.13, RHEA:16716]


id: GO:0050274
name: salicyl-alcohol beta-D-glucosyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: salicyl alcohol + UDP-D-glucose = H(+) + salicin + UDP." [EC:2.4.1.172, RHEA:11515]


id: GO:0050275
name: scopoletin glucosyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: scopoletin + UDP-D-glucose = H(+) + scopolin + UDP." [EC:2.4.1.128, RHEA:20456]


id: GO:0050276
name: scyllo-inosamine 4-kinase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 1-amino-1-deoxy-scyllo-inositol + ATP = 1-amino-1-deoxy-scyllo-inositol 4-phosphate + ADP + 2 H(+)." [EC:2.7.1.65, RHEA:18608]


id: GO:0050277
name: sedoheptulokinase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: ATP + sedoheptulose = ADP + 2 H(+) + sedoheptulose 7-phosphate." [EC:2.7.1.14, RHEA:23847]


id: GO:0050278
name: sedoheptulose-bisphosphatase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: sedoheptulose 1,7-bisphosphate + H2O = sedoheptulose 7-phosphate + phosphate." [EC:3.1.3.37, MetaCyc:SEDOHEPTULOSE-BISPHOSPHATASE-RXN]


id: GO:0050279
name: sepiapterin deaminase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: sepiapterin + H2O = xanthopterin-B2 + NH3." [EC:3.5.4.24, MetaCyc:SEPIAPTERIN-DEAMINASE-RXN]


id: GO:0050280
name: sequoyitol dehydrogenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 1D-5-O-methyl-myo-inositol + NAD(+) = 2D-5-O-methyl-2,3,5/4,6-pentahydroxycyclohexanone + H(+) + NADH." [EC:1.1.1.143, RHEA:11303]


id: GO:0050281
name: serine-glyoxylate transaminase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: L-serine + glyoxylate = 3-hydroxypyruvate + glycine." [EC:2.6.1.45, MetaCyc:SERINE--GLYOXYLATE-AMINOTRANSFERASE-RXN]


id: GO:0050282
name: serine 2-dehydrogenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: L-serine + H2O + NAD+ = 3-hydroxypyruvate + NH3 + NADH." [EC:1.4.1.7, MetaCyc:SERINE-DEHYDROGENASE-RXN]


id: GO:0050283
name: serine-sulfate ammonia-lyase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: L-serine O-sulfate + H2O = pyruvate + NH3 + sulfate." [EC:4.3.1.10, MetaCyc:SERINE-SULFATE-AMMONIA-LYASE-RXN]


id: GO:0050284
name: sinapate 1-glucosyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: UDP-glucose + sinapate = UDP + 1-sinapoyl-D-glucose." [EC:2.4.1.120, MetaCyc:SINAPATE-1-GLUCOSYLTRANSFERASE-RXN]


id: GO:0050285
name: sinapine esterase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: O-sinapoylcholine + H(2)O = choline + H(+) + sinapate." [EC:3.1.1.49, RHEA:10019]


id: GO:0050286
name: sorbitol-6-phosphatase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: D-glucitol 6-phosphate + H(2)O = D-glucitol + phosphate." [EC:3.1.3.50, RHEA:24583]


id: GO:0050287
name: sorbose 5-dehydrogenase (NADP+) activity
namespace: molecular_function
def:
  "Catalysis of the reaction: L-sorbose + NADP(+) = 5-dehydro-D-fructose + H(+) + NADPH." [EC:1.1.1.123, RHEA:15004]


id: GO:0050288
name: sorbose dehydrogenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: L-sorbose + A = 5-dehydro-D-fructose + AH(2)." [EC:1.1.99.12, RHEA:14716]


id: GO:0050289
name: spermidine dehydrogenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: spermidine + acceptor + H2O = 1,3-diaminopropane + 4-aminobutanal + reduced acceptor." [EC:1.5.99.6, MetaCyc:SPERMIDINE-DEHYDROGENASE-RXN]


id: GO:0050290
name: sphingomyelin phosphodiesterase D activity
namespace: molecular_function
def:
  "Catalysis of the reaction: H(2)O + sphingomyelin = ceramide 1-phosphate + choline + H(+)." [EC:3.1.4.41, RHEA:20987]


id: GO:0050291
name: sphingosine N-acyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: acyl-CoA + sphingosine = CoA + N-acylsphingosine." [EC:2.3.1.24, MetaCyc:SPHINGOSINE-N-ACYLTRANSFERASE-RXN, PMID:12069845]


id: GO:0050292
name: steroid 9-alpha-monooxygenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: AH(2) + O(2) + pregna-4,9(11)-diene-3,20-dione = 9,11alpha-epoxypregn-4-ene-3,20-dione + A + H(2)O." [EC:1.14.99.24, RHEA:19560]


id: GO:0050294
name: steroid sulfotransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + a phenolic steroid = adenosine 3',5'-bisphosphate + steroid O-sulfate." [EC:2.8.2.15, MetaCyc:STEROID-SULFOTRANSFERASE-RXN]


id: GO:0050295
name: steryl-beta-glucosidase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: cholesteryl-beta-D-glucoside + H(2)O = D-glucose + cholesterol." [EC:3.2.1.104, RHEA:11959]


id: GO:0050296
name: stipitatonate decarboxylase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: H(2)O + stipitatonate = CO(2) + H(+) + stipitatate." [EC:4.1.1.60, RHEA:13888]


id: GO:0050297
name: stizolobate synthase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 3,4-dihydroxy-L-phenylalanine + O2 = 4-(L-alanin-3-yl)-2-hydroxy-cis,cis-muconate 6-semialdehyde." [EC:1.13.11.29, MetaCyc:STIZOLOBATE-SYNTHASE-RXN]


id: GO:0050298
name: stizolobinate synthase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 3,4-dihydroxy-L-phenylalanine + O2 = 5-(L-alanin-3-yl)-2-hydroxy-cis,cis-muconate 6-semialdehyde." [EC:1.13.11.30, MetaCyc:STIZOLOBINATE-SYNTHASE-RXN]


id: GO:0050299
name: streptomycin 3''-kinase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: ATP + streptomycin = ADP + 2 H(+) + streptomycin 3''-phosphate." [EC:2.7.1.87, RHEA:18380]


id: GO:0050300
name: aminoglycoside 6-kinase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: ATP + streptomycin = ADP + 2 H(+) + streptomycin 6-phosphate." [EC:2.7.1.72, RHEA:22271]


id: GO:0050301
name: streptomycin-6-phosphatase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: H(2)O + streptomycin 6-phosphate = phosphate + streptomycin." [EC:3.1.3.39, RHEA:10691]


id: GO:0050302
name: indole-3-acetaldehyde oxidase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: (indol-3-yl)acetaldehyde + H(2)O + O(2) = (indol-3-yl)acetate + H(2)O(2) + H(+)." [EC:1.2.3.7, RHEA:16280]


id: GO:0050303
name: lysine 6-dehydrogenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: H2O + NAD+ + L-lysine = NH3 + NADH + allysine." [EC:1.4.1.18, MetaCyc:LYSINE-6-DEHYDROGENASE-RXN]


id: GO:0050304
name: nitrous-oxide reductase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: H(2)O + 2 cytochrome c + nitrogen = 2 reduced cytochrome c + nitrous oxide." [EC:1.7.2.4, MetaCyc:RXN-12130]


id: GO:0050305
name: strombine dehydrogenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: N-(carboxymethyl)-D-alanine + H(2)O + NAD(+) = glycine + H(+) + NADH + pyruvate." [EC:1.5.1.22, RHEA:14064]


id: GO:0050306
name: sucrose 1F-fructosyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 2 sucrose = D-glucose + 1F-beta-D-fructosylsucrose." [EC:2.4.1.99, MetaCyc:SUCROSE-1F-FRUCTOSYLTRANSFERASE-RXN]


id: GO:0050307
name: sucrose-phosphate phosphatase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: sucrose 6F-phosphate + H2O = sucrose + phosphate." [EC:3.1.3.24, MetaCyc:SUCROSE-PHOSPHATASE-RXN]


id: GO:0050308
name: sugar-phosphatase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: sugar phosphate + H2O = sugar + phosphate." [EC:3.1.3.23, MetaCyc:SUGAR-PHOSPHATASE-RXN]


id: GO:0050309
name: sugar-terminal-phosphatase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: H2O + sugar phosphorylated on the terminal carbon = a sugar + phosphate." [EC:3.1.3.58, MetaCyc:SUGAR-TERMINAL-PHOSPHATASE-RXN]


id: GO:0050310
name: sulfite dehydrogenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: sulfite + 2 ferricytochrome c + H2O = sulfate + 2 ferrocytochrome c." [EC:1.8.2.1, MetaCyc:SULFITE-DEHYDROGENASE-RXN]


id: GO:0050311
name: sulfite reductase (ferredoxin) activity
namespace: molecular_function
def:
  "Catalysis of the reaction: hydrogen sulfide + 3 oxidized ferredoxin + 3 H2O = sulfite + 3 reduced ferredoxin." [EC:1.8.7.1, MetaCyc:SULFITE-REDUCTASE-FERREDOXIN-RXN]


id: GO:0050312
name: sulfoacetaldehyde lyase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 2-sulfoacetaldehyde + H2O = acetate + sulfite." [EC:4.4.1.12, MetaCyc:SULFOACETALDEHYDE-LYASE-RXN]


id: GO:0050313
name: sulfur dioxygenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: sulfur + O2 + H2O = sulfite." [EC:1.13.11.18, MetaCyc:SULFUR-DIOXYGENASE-RXN]


id: GO:0050314
name: sym-norspermidine synthase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 1,3-diaminopropane + S-adenosylmethioninamine = S-methyl-5'-thioadenosine + bis(3-aminopropyl)amine + H(+)." [EC:2.5.1.23, RHEA:23247]


id: GO:0050315
name: synephrine dehydratase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: synephrine = (4-hydroxyphenyl)acetaldehyde + methylammonium." [EC:4.2.1.88, RHEA:17516]


id: GO:0050316
name: T2-induced deoxynucleotide kinase activity
namespace: molecular_function
def:
  "Catalysis of the reactions: ATP + dGMP = ADP + dGDP, and ATP + dTMP = ADP + dTDP." [EC:2.7.4.12, MetaCyc:T2-INDUCED-DEOXYNUCLEOTIDE-KINASE-RXN]


id: GO:0050317
name: tagatose kinase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: D-tagatose + ATP = D-tagatose 6-phosphate + ADP + 2 H(+)." [EC:2.7.1.101, RHEA:15516]


id: GO:0050321
name: tau-protein kinase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: ATP + tau-protein = ADP + O-phospho-tau-protein." [EC:2.7.11.26, MetaCyc:TAU-PROTEIN-KINASE-RXN]


id: GO:0050322
name: taurine-2-oxoglutarate transaminase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: taurine + 2-oxoglutarate = sulfoacetaldehyde + L-glutamate." [EC:2.6.1.55, MetaCyc:RXN-2301]


id: GO:0050323
name: taurine dehydrogenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: A + H(2)O + taurine = AH(2) + NH(4)(+) + sulfoacetaldehyde." [EC:1.4.99.2, RHEA:18712]


id: GO:0050324
name: taurocyamine kinase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: ATP + taurocyamine = N-phosphotaurocyamine + ADP + 2 H(+)." [EC:2.7.3.4, RHEA:22519]


id: GO:0050325
name: tauropine dehydrogenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: H(2)O + NAD(+) + tauropine = H(+) + NADH + pyruvate + taurine." [EC:1.5.1.23, RHEA:12583]


id: GO:0050326
name: taxifolin 8-monooxygenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: taxifolin + NAD(P)H + H+ + O2 = 2,3-dihydrogossypetin + NAD(P)+ + H2O." [EC:1.14.13.19, MetaCyc:TAXIFOLIN-8-MONOOXYGENASE-RXN]


id: GO:0050328
name: tetrahydroberberine oxidase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: (S)-tetrahydroberberine + 2 O2 = berberine + 2 H2O2." [EC:1.3.3.8, MetaCyc:TETRAHYDROBERBERINE-OXIDASE-RXN]


id: GO:0050329
name: tetrahydroxypteridine cycloisomerase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: tetrahydroxypteridine = H(+) + xanthine-8-carboxylate." [EC:5.5.1.3, RHEA:18100]


id: GO:0050330
name: theanine hydrolase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: N(5)-ethyl-L-glutamine + H(2)O = L-glutamate + ethylamine." [EC:3.5.1.65, RHEA:18016]


id: GO:0050331
name: thiamine-diphosphate kinase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: ATP + thiamin diphosphate = ADP + thiamin triphosphate." [EC:2.7.4.15, MetaCyc:THIAMIN-DIPHOSPHATE-KINASE-RXN]


id: GO:0050332
name: thiamine pyridinylase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: pyridine + thiamine = 5-(2-hydroxyethyl)-4-methylthiazole + heteropyrithiamine." [EC:2.5.1.2, RHEA:17700]


id: GO:0050333
name: thiamin-triphosphatase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: H(2)O + thiamine triphosphate = H(+) + phosphate + thiamine diphosphate." [EC:3.6.1.28, RHEA:11747]


id: GO:0050334
name: thiaminase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: H(2)O + thiamine = 4-amino-5-hydroxymethyl-2-methylpyrimidine + 5-(2-hydroxyethyl)-4-methylthiazole + H(+)." [EC:3.5.99.2, RHEA:17512]


id: GO:0050336
name: thioethanolamine S-acetyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: acetyl-CoA + cysteamine = S-acetylcysteamine + CoA." [EC:2.3.1.11, RHEA:23283]


id: GO:0050337
name: thiosulfate-thiol sulfurtransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: thiosulfate + 2 glutathione = sulfite + glutathione disulfide + sulfide." [EC:2.8.1.3, MetaCyc:THIOSULFATE--THIOL-SULFURTRANSFERASE-RXN]


id: GO:0050338
name: thiosulfate dehydrogenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 2 thiosulfate + 2 ferricytochrome c = tetrathionate + 2 ferrocytochrome c." [EC:1.8.2.2, MetaCyc:THIOSULFATE-DEHYDROGENASE-RXN]


id: GO:0050339
name: thymidine-triphosphatase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: dTTP + H2O = dTDP + phosphate." [EC:3.6.1.39, MetaCyc:THYMIDINE-TRIPHOSPHATASE-RXN]


id: GO:0050340
name: thymidylate 5'-phosphatase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: thymidylate + H2O = thymidine + phosphate." [EC:3.1.3.35, MetaCyc:THYMIDYLATE-5-PHOSPHATASE-RXN]


id: GO:0050341
name: thymine dioxygenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: thymine + 2-oxoglutarate + O2 = 5-hydroxymethyluracil + succinate + CO2." [EC:1.14.11.6, MetaCyc:THYMINE-DIOXYGENASE-RXN]


id: GO:0050342
name: tocopherol O-methyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: S-adenosyl-L-methionine + gamma-tocopherol = S-adenosyl-L-homocysteine + alpha-tocopherol." [EC:2.1.1.95, MetaCyc:TOCOPHEROL-O-METHYLTRANSFERASE-RXN]


id: GO:0050343
name: trans-2-enoyl-CoA reductase (NAD+) activity
namespace: molecular_function
def:
  "Catalysis of the reaction: acyl-CoA + NAD+ = trans-didehydroacyl-CoA + NADH." [EC:1.3.1.44, MetaCyc:TRANS-2-ENOYL-COA-REDUCTASE-NAD+-RXN]


id: GO:0050344
name: trans-cinnamate 2-monooxygenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: trans-cinnamate + H(+) + NADPH + O(2) = 2-coumarate + H(2)O + NADP(+)." [EC:1.14.13.14, RHEA:10959]


id: GO:0050345
name: trans-epoxysuccinate hydrolase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: trans-2,3-epoxysuccinate + H(2)O = (2R,3S)-tartrate." [EC:3.3.2.4, RHEA:20743]


id: GO:0050346
name: trans-L-3-hydroxyproline dehydratase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: trans-L-3-hydroxyproline = 1-pyrroline-2-carboxylate + H(2)O + H(+)." [EC:4.2.1.77, RHEA:10323]


id: GO:0050347
name: trans-octaprenyltranstransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: all-trans-octaprenyl diphosphate + isopentenyl diphosphate = all-trans-nonaprenyl diphosphate + diphosphate." [RHEA:11327]


id: GO:0050348
name: trehalose O-mycolyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 2 alpha,alpha'-trehalose 6-mycolate = alpha,alpha'-trehalose 6,6'-bismycolate + alpha,alpha-trehalose." [EC:2.3.1.122, RHEA:23475]


id: GO:0050350
name: trihydroxystilbene synthase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 3 malonyl-CoA + 4-coumaroyl-CoA = 4 CoA + 3,4',5-trihydroxy-stilbene + 4 CO2." [EC:2.3.1.95, MetaCyc:TRIHYDROXYSTILBENE-SYNTHASE-RXN]


id: GO:0050351
name: trimetaphosphatase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: H(2)O + trimetaphosphate = 2 H(+) + triphosphate." [EC:3.6.1.2, RHEA:11091]


id: GO:0050352
name: trimethylamine-oxide aldolase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: H(+) + trimethylamine N-oxide = dimethylamine + formaldehyde." [EC:4.1.2.32, RHEA:20220]


id: GO:0050353
name: trimethyllysine dioxygenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysine + O(2) = 3-hydroxy-N(6),N(6),N(6)-trimethyl-L-lysine + CO(2) + succinate." [EC:1.14.11.8, RHEA:14184]


id: GO:0050354
name: triokinase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: D-glyceraldehyde + ATP = D-glyceraldehyde 3-phosphate + ADP + 2 H(+)." [EC:2.7.1.28, RHEA:13944]


id: GO:0050355
name: triphosphatase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: H(2)O + triphosphate = diphosphate + phosphate." [EC:3.6.1.25, RHEA:14160]


id: GO:0050356
name: tropine dehydrogenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: NADP(+) + tropine = H(+) + NADPH + tropinone." [EC:1.1.1.206, RHEA:18360]


id: GO:0050358
name: tropinone reductase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: NADP(+) + pseudotropine = H(+) + NADPH + tropinone." [EC:1.1.1.236, RHEA:24247]


id: GO:0050359
name: tropomyosin kinase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: ATP + tropomyosin = ADP + O-phosphotropomyosin." [EC:2.7.11.28, MetaCyc:TROPOMYOSIN-KINASE-RXN]


id: GO:0050360
name: tryptophan 2'-dioxygenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: L-tryptophan + O2 = 3-indoleglycolaldehyde + CO2 + NH3." [EC:1.13.99.3, MetaCyc:TRYPTOPHAN-2-DIOXYGENASE-RXN]


id: GO:0050361
name: tryptophan 2-monooxygenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: L-tryptophan + O(2) = CO(2) + H(2)O + indole-3-acetamide." [EC:1.13.12.3, RHEA:16168]


id: GO:0050362
name: L-tryptophan:2-oxoglutarate aminotransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: L-tryptophan + 2-oxoglutarate = indolepyruvate + L-glutamate." [EC:2.6.1.27, MetaCyc:TRYPTOPHAN-AMINOTRANSFERASE-RXN]


id: GO:0050363
name: tryptophan dehydrogenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: L-tryptophan + NAD(P)+ = (indol-3-yl)pyruvate + NH3 + NAD(P)H + H+." [EC:1.4.1.19, MetaCyc:TRYPTOPHAN-DEHYDROGENASE-RXN]


id: GO:0050364
name: tryptophan dimethylallyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: dimethylallyl diphosphate + L-tryptophan = diphosphate + 4-(3-methylbut-2-enyl)-L-tryptophan." [EC:2.5.1.34, MetaCyc:TRYPTOPHAN-DIMETHYLALLYLTRANSFERASE-RXN]


id: GO:0050365
name: tryptophanamidase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: L-tryptophanamide + H(2)O = L-tryptophan + NH(4)(+)." [EC:3.5.1.57, RHEA:11015]


id: GO:0050366
name: tyramine N-feruloyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: feruloyl-CoA + tyramine = CoA + N-feruloyltyramine." [EC:2.3.1.110, MetaCyc:TYRAMINE-N-FERULOYLTRANSFERASE-RXN]


id: GO:0050367
name: tyrosine-arginine ligase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: L-arginine + L-tyrosine + ATP = L-tyrosyl-L-arginine + AMP + diphosphate + 2 H(+)." [EC:6.3.2.24, RHEA:15348]


id: GO:0050368
name: tyrosine 2,3-aminomutase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: L-tyrosine = 3-amino-3-(4-hydroxyphenyl)propanoate." [EC:5.4.3.6, RHEA:15784]


id: GO:0050369
name: [tyrosine 3-monooxygenase] kinase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: ATP + [tyrosine-3-monooxygenase] = ADP + phospho-[tyrosine-3-monooxygenase]." [EC:2.7.11.6, MetaCyc:TYROSINE-3-MONOOXYGENASE-KINASE-RXN]


id: GO:0050370
name: tyrosine N-monooxygenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: tyrosine + O2 + NADPH + H+ = N-hydroxytyrosine + NADP+ + H2O." [EC:1.14.13.41, MetaCyc:TYROSINE-N-MONOOXYGENASE-RXN]


id: GO:0050371
name: tyrosine phenol-lyase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: L-tyrosine + H(2)O = NH(4)(+) + phenol + pyruvate." [EC:4.1.99.2, RHEA:21707]


id: GO:0050372
name: ubiquitin-calmodulin ligase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: n ATP + calmodulin + n ubiquitin = n AMP + n diphosphate + ubiquitin(n)-calmodulin." [MetaCyc:UBIQUITIN--CALMODULIN-LIGASE-RXN]


id: GO:0050374
name: UDP-galacturonate decarboxylase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: H(+) + UDP-alpha-D-galacturonate = CO(2) + UDP-L-arabinose." [EC:4.1.1.67, RHEA:19728]


id: GO:0050376
name: UDP-glucosamine 4-epimerase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: UDP-glucosamine = UDP-galactosamine." [EC:5.1.3.16, MetaCyc:UDP-GLUCOSAMINE-EPIMERASE-RXN]


id: GO:0050377
name: UDP-glucose 4,6-dehydratase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: UDP-D-glucose = H(2)O + UDP-4-dehydro-6-deoxy-D-glucose." [EC:4.2.1.76, RHEA:21503]


id: GO:0050378
name: UDP-glucuronate 4-epimerase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: UDP-alpha-D-glucuronate = UDP-alpha-D-galacturonate." [EC:5.1.3.6, RHEA:11407]


id: GO:0050380
name: undecaprenyl-diphosphatase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: all-trans-undecaprenyl diphosphate + H(2)O = all-trans-undecaprenyl phosphate + H(+) + phosphate." [EC:3.6.1.27, RHEA:17072]


id: GO:0050382
name: uracil-5-carboxylate decarboxylase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: H(+) + uracil 5-carboxylate = CO(2) + uracil." [EC:4.1.1.66, RHEA:17688]


id: GO:0050383
name: uracil dehydrogenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: uracil + acceptor = barbiturate + reduced acceptor." [EC:1.17.99.4, MetaCyc:URACIL-DEHYDROGENASE-RXN]


id: GO:0050384
name: urate-ribonucleotide phosphorylase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 3-(beta-D-ribofuranosyl)uric acid + phosphate = alpha-D-ribose 1-phosphate + H(+) + urate." [EC:2.4.2.16, RHEA:13912]


id: GO:0050386
name: ureidosuccinase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: N-carbamoyl-L-aspartate + H(2)O + 2 H(+) = L-aspartate + CO(2) + NH(4)(+)." [EC:3.5.1.7, RHEA:14368]


id: GO:0050387
name: urethanase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: H(2)O + H(+) + urethane = CO(2) + ethanol + NH(4)(+)." [EC:3.5.1.75, RHEA:21375]


id: GO:0050388
name: uronate dehydrogenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: D-galacturonate + H(2)O + NAD(+) = galactarate + 2 H(+) + NADH." [EC:1.1.1.203, RHEA:22407]


id: GO:0050389
name: uronolactonase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: D-glucurono-6,2-lactone + H2O = D-glucuronate." [EC:3.1.1.19, MetaCyc:URONOLACTONASE-RXN]


id: GO:0050390
name: valine decarboxylase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: L-valine + H(+) = 2-methylpropanamine + CO(2)." [EC:4.1.1.14, RHEA:18992]


id: GO:0050391
name: valine dehydrogenase (NADP) activity
namespace: molecular_function
def:
  "Catalysis of the reaction: L-valine + H2O + NADP+ = 3-methyl-2-oxobutanoate + NH3 + NADPH." [EC:1.4.1.8, MetaCyc:VALINE-DEHYDROGENASE-NADP+-RXN]


id: GO:0050392
name: vicianin beta-glucosidase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: (R)-vicianin + H(2)O = mandelonitrile + vicianose." [EC:3.2.1.119, RHEA:14044]


id: GO:0050394
name: viomycin kinase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: ATP + viomycin = ADP + O-phosphoviomycin." [EC:2.7.1.103, MetaCyc:VIOMYCIN-KINASE-RXN]


id: GO:0050395
name: vitexin beta-glucosyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: UDP-D-glucose + vitexin = H(+) + UDP + vitexin 2''-O-beta-D-glucoside." [EC:2.4.1.105, RHEA:21959]


id: GO:0050396
name: vomifoliol 4'-dehydrogenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: (6S,9R)-6-hydroxy-3-oxo-alpha-ionol + NAD(+) = (6S)-6-hydroxy-3-oxo-alpha-ionone + H(+) + NADH." [EC:1.1.1.221, RHEA:22807]


id: GO:0050397
name: Watasenia-luciferin 2-monooxygenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: Watasenia luciferin + O2 = oxidized Watasenia luciferin + CO2 + light." [EC:1.13.12.8, MetaCyc:WATASEMIA-LUCIFERIN-2-MONOOXYGENASE-RXN]


id: GO:0050398
name: wax-ester hydrolase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: a wax ester + H2O = a long-chain alcohol + a long-chain carboxylate." [EC:3.1.1.50, MetaCyc:WAX-ESTER-HYDROLASE-RXN]


id: GO:0050399
name: xanthommatin reductase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 5,12-dihydroxanthommatin + NAD(+) = H(+) + NADH + xanthommatin." [EC:1.3.1.41, RHEA:13420]


id: GO:0050400
name: xylitol kinase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: ATP + xylitol = ADP + 2 H(+) + xylitol 5-phosphate." [EC:2.7.1.122, RHEA:20212]


id: GO:0050401
name: xylonate dehydratase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: D-xylonate = 2-dehydro-3-deoxy-D-arabinonate + H(2)O." [EC:4.2.1.82, RHEA:19160]


id: GO:0050402
name: xylono-1,4-lactonase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: D-xylono-1,4-lactone + H2O = D-xylonate." [EC:3.1.1.68, MetaCyc:XYLONO-14-LACTONASE-RXN]


id: GO:0050403
name: trans-zeatin O-beta-D-glucosyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: trans-zeatin + UDP-D-glucose = O-beta-D-glucosyl-trans-zeatin + H(+) + UDP." [EC:2.4.1.203, RHEA:23227]


id: GO:0050404
name: zeatin O-beta-D-xylosyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: UDP-alpha-D-xylose + zeatin = O-beta-D-xylosylzeatin + H(+) + UDP." [EC:2.4.2.40, RHEA:14724]


id: GO:0050405
name: [acetyl-CoA carboxylase] kinase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: ATP + [acetyl-CoA carboxylase] = ADP + [acetyl-CoA carboxylase] phosphate." [EC:2.7.11.27, MetaCyc:[ACETYL-COA-CARBOXYLASE\]-KINASE-RXN]


id: GO:0050406
name: [acetyl-CoA carboxylase]-phosphatase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: [acetyl-CoA carboxylase]-phosphate + H2O = [acetyl-CoA carboxylase] + phosphate." [EC:3.1.3.44, MetaCyc:ACETYL-COA-CARBOXYLASE-PHOSPHATASE-RXN]


id: GO:0050407
name: [glycogen-synthase-D] phosphatase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: [glycogen-synthase D] + H2O = [glycogen-synthase I] + phosphate." [EC:3.1.3.42, MetaCyc:GLYCOGEN-SYNTHASE-D-PHOSPHATASE-RXN]


id: GO:0050408
name: [pyruvate kinase]-phosphatase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: [pyruvate kinase] phosphate + H2O = [pyruvate kinase] + phosphate." [EC:3.1.3.49, MetaCyc:PYRUVATE-KINASE-PHOSPHATASE-RXN]


id: GO:0050409
name: indolylacetylinositol arabinosyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 1L-1-O-(indol-3-yl)acetyl-myo-inositol + UDP-L-arabinose = (indol-3-yl)acetyl-myo-inositol 3-L-arabinoside + H(+) + UDP." [EC:2.4.2.34, RHEA:19508]


id: GO:0050411
name: agaritine gamma-glutamyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: agaritine + acceptor-NH2 = 4-hydroxymethylphenylhydrazine + gamma-L-glutamyl-acceptor." [EC:2.3.2.9, MetaCyc:AGARITINE-GAMMA-GLUTAMYLTRANSFERASE-RXN]


id: GO:0050412
name: cinnamate beta-D-glucosyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: trans-cinnamate + UDP-D-glucose = 1-O-trans-cinnamoyl-beta-D-glucopyranose + UDP." [EC:2.4.1.177, RHEA:13440]


id: GO:0050413
name: D-alanine 2-hydroxymethyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 5,10-methylenetetrahydrofolate + D-alanine + H(2)O = (6S)-5,6,7,8-tetrahydrofolate + 2-methylserine." [EC:2.1.2.7, RHEA:10067]


id: GO:0050414
name: formimidoylaspartate deiminase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: N-formimidoyl-L-aspartate + H2O = N-formyl-L-aspartate + NH3." [EC:3.5.3.5, MetaCyc:FORMIMINOASPARTATE-DEIMINASE-RXN]


id: GO:0050415
name: formimidoylglutamase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: N-formimidoyl-L-glutamate + H(2)O = L-glutamate + formamide." [EC:3.5.3.8, RHEA:22495]


id: GO:0050416
name: formimidoylglutamate deiminase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: N-formimidoyl-L-glutamate + H2O = N-formyl-L-glutamate + NH3." [EC:3.5.3.13, MetaCyc:FORMIMINOGLUTAMATE-DEIMINASE-RXN]


id: GO:0050417
name: glutamin-(asparagin-)ase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: H2O + L-glutamine = NH3 + L-glutamate; and H2O + L-asparagine = NH3 + L-aspartate." [EC:3.5.1.38, MetaCyc:GLUTAMINASE-ASPARAGIN-ASE-RXN]


id: GO:0050418
name: hydroxylamine reductase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: NH3 + H2O + acceptor = hydroxylamine + reduced acceptor." [EC:1.7.99.1, MetaCyc:HYDROXYLAMINE-REDUCTASE-RXN]


id: GO:0050419
name: hydroxymandelonitrile lyase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 4-hydroxymandelonitrile = 4-hydroxybenzaldehyde + hydrocyanate." [EC:4.1.2.11, MetaCyc:HYDROXYMANDELONITRILE-LYASE-RXN]


id: GO:0050420
name: maltose synthase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 2 alpha-D-glucose 1-phosphate = maltose + 2 phosphate." [EC:2.4.1.139, MetaCyc:MALTOSE-SYNTHASE-RXN]


id: GO:0050421
name: nitrite reductase (NO-forming) activity
namespace: molecular_function
def:
  "Catalysis of the reaction: nitric oxide + H2O + ferricytochrome c = nitrite + ferrocytochrome c + 2 H+." [EC:1.7.2.1, MetaCyc:NITRITE-REDUCTASE-CYTOCHROME-RXN]


id: GO:0050422
name: strictosidine beta-glucosidase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 3alpha(S)-strictosidine + H(2)O = D-glucose + strictosidine aglycone." [EC:3.2.1.105, RHEA:12920]


id: GO:0050423
name: thiamine oxidase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: thiamine + 2 O2 = thiamine acetic acid + 2 H2O2." [EC:1.1.3.23, MetaCyc:THIAMIN-OXIDASE-RXN]


id: GO:0050424
name: obsolete alanine carboxypeptidase activity
namespace: molecular_function
def:
  "OBSOLETE. Catalysis of the reaction: H2O + peptidyl-L-alanine = L-alanine + peptide. The release of a C-terminal alanine from a peptide or a variety of pteroyl or acyl groups." [EC:3.4.17.6, MetaCyc:ALANINE-CARBOXYPEPTIDASE-RXN]


id: GO:0050425
name: obsolete carboxypeptidase B activity
namespace: molecular_function
def:
  "OBSOLETE. Catalysis of the reaction: H2O + peptidyl-L-lysine (or L-arginine) = L-lysine (or L-arginine) + peptide. Preferential release of a C-terminal lysine or arginine amino acid." [EC:3.4.17.2, MetaCyc:CARBOXYPEPTIDASE-B-RXN]


id: GO:0050426
name: obsolete peptidyl-glycinamidase activity
namespace: molecular_function
def:
  "OBSOLETE. Catalysis of the reaction: H2O + peptidyl-glycinamide = glycinamide + peptide. Cleavage of C-terminal glycinamide from a polypeptide." [EC:3.4.19.2, MetaCyc:PEPTIDYL-GLYCINAMIDASE-RXN]


id: GO:0050427
name: 3'-phosphoadenosine 5'-phosphosulfate metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving 3'-phosphoadenosine 5'-phosphosulfate, a naturally occurring mixed anhydride. It is an intermediate in the formation of a variety of sulfo compounds in biological systems." [ISBN:0198506732]


id: GO:0050428
name: 3'-phosphoadenosine 5'-phosphosulfate biosynthetic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of 3'-phosphoadenosine 5'-phosphosulfate, a naturally occurring mixed anhydride. It is an intermediate in the formation of a variety of sulfo compounds in biological systems." [ISBN:0198506732]


id: GO:0050429
name: calcium-dependent phospholipase C activity
namespace: molecular_function
def:
  "Catalysis of the reaction: a phosphatidylcholine + H2O = 1,2-diacylglycerol + choline phosphate. This reaction requires Ca2+." [EC:3.1.4.3]


id: GO:0050431
name: transforming growth factor beta binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with TGF-beta, transforming growth factor beta, a multifunctional peptide that controls proliferation, differentiation and other functions in many cell types." [ISBN:0198506732]


id: GO:0050432
name: catecholamine secretion
namespace: biological_process
def:
  "The regulated release of catecholamines by a cell. The catecholamines are a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine." [GOC:ai, GOC:ef]


id: GO:0050433
name: regulation of catecholamine secretion
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of the regulated release of catecholamines." [GOC:ai]


id: GO:0050434
name: positive regulation of viral transcription
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of viral transcription." [GOC:ai]


id: GO:0050435
name: beta-amyloid metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving beta-amyloid, a glycoprotein associated with Alzheimer's disease, and its precursor, amyloid precursor protein (APP)." [GOC:ai]


id: GO:0050436
name: microfibril binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with a microfibril, any small fibril occurring in biological material." [GOC:ai]


id: GO:0050437
name: (-)-endo-fenchol synthase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: geranyl diphosphate + H(2)O = (-)-endo-fenchol + diphosphate." [EC:4.2.3.10, RHEA:20568]


id: GO:0050438
name: 2-ethylmalate synthase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 2-oxobutanate + acetyl-CoA + H(2)O = (R)-2-ethylmalate + CoA + H(+)." [EC:2.3.3.6, RHEA:23043]


id: GO:0050439
name: 2-hydroxy-3-oxoadipate synthase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 2-oxoglutarate + glyoxylate + H(+) = 2-hydroxy-3-oxoadipate + CO(2)." [EC:2.2.1.5, RHEA:14344]


id: GO:0050440
name: 2-methylcitrate synthase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: H(2)O + oxaloacetate + propanoyl-CoA = (2R,3S)-2-methylcitrate + CoA + H(+)." [EC:2.3.3.5, RHEA:23783]


id: GO:0050441
name: 3-ethylmalate synthase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: butanoyl-CoA + glyoxylate + H(2)O = 3-ethylmalate + CoA + H(+)." [EC:2.3.3.7, RHEA:10503]


id: GO:0050442
name: 3-propylmalate synthase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: glyoxylate + H(2)O + pentanoyl-CoA = 3-propylmalate + CoA + H(+)." [EC:2.3.3.12, RHEA:14460]


id: GO:0050444
name: aquacobalamin reductase (NADPH) activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 2 cob(II)alamin + NADP+ = 2 aquacob(III)alamin + NADPH + H+." [EC:1.16.1.5, MetaCyc:AQUACOBALAMIN-REDUCTASE-NADPH-RXN]


id: GO:0050445
name: asparagusate reductase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 3-mercapto-2-mercaptomethylpropanoate + NAD(+) = asparagusate + H(+) + NADH." [EC:1.8.1.11, RHEA:14884]


id: GO:0050446
name: azobenzene reductase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: N,N-dimethyl-1,4-phenylenediamine + aniline + NADP+ = 4-(dimethylamino)azobenzene + NADPH + H+." [EC:1.7.1.6, MetaCyc:AZOBENZENE-REDUCTASE-RXN]


id: GO:0050447
name: zeatin 9-aminocarboxyethyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: O-acetyl-L-serine + zeatin = L-lupinate + acetate + H(+)." [EC:2.5.1.50, RHEA:17336]


id: GO:0050448
name: beta-cyclopiazonate dehydrogenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: beta-cyclopiazonate + A = alpha-cyclopiazonate + AH(2)." [EC:1.21.99.1, RHEA:14526]


id: GO:0050449
name: casbene synthase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: all-trans-geranylgeranyl diphosphate = casbene + diphosphate." [EC:4.2.3.8, RHEA:14904]


id: GO:0050450
name: citrate (Re)-synthase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: acetyl-CoA + H2O + oxaloacetate = citrate + CoA, where the acetyl group is added to the re-face of oxaloacetate; acetyl-CoA provides the two carbon atoms of the pro-R carboxymethyl group." [EC:2.3.3.3, ISBN:0121227073, MetaCyc:CITRATE-RE-SYNTHASE-RXN]


id: GO:0050451
name: CoA-disulfide reductase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 2 CoA + NAD+ = CoA-disulfide + NADH + H+." [EC:1.8.1.14, MetaCyc:COA-DISULFIDE-REDUCTASE-NADH-RXN]


id: GO:0050452
name: CoA-glutathione reductase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: CoA + glutathione + NADP+ = CoA-glutathione + NADPH + H+." [EC:1.8.1.10, MetaCyc:COA-GLUTATHIONE-REDUCTASE-NADPH-RXN]


id: GO:0050453
name: cob(II)alamin reductase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 2 cob(I)alamin + H(+) + NAD(+) = 2 cob(II)alamin + NADH." [EC:1.16.1.4, RHEA:17484]


id: GO:0050454
name: coenzyme F420 hydrogenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: coenzyme F420 + H(2) + H(+) = reduced coenzyme F420." [EC:1.12.98.1, RHEA:23763]


id: GO:0050455
name: columbamine oxidase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 2 columbamine + O(2) = 2 berberine + 2 H(2)O." [EC:1.21.3.2, RHEA:23567]


id: GO:0050456
name: cystine reductase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 2 L-cysteine + NAD(+) = L-cystine + H(+) + NADH." [EC:1.8.1.6, RHEA:20600]


id: GO:0050457
name: decylcitrate synthase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: H(2)O + lauroyl-CoA + oxaloacetate = (2S,3S)-2-hydroxytridecane-1,2,3-tricarboxylate + CoA + H(+)." [EC:2.3.3.2, RHEA:16608]


id: GO:0050458
name: decylhomocitrate synthase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 2-oxoglutarate + H(2)O + lauroyl-CoA = (3S,4S)-3-hydroxytetradecane-1,3,4-tricarboxylate + CoA + H(+)." [EC:2.3.3.4, RHEA:10367]


id: GO:0050459
name: ethanolamine-phosphate phospho-lyase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: H(2)O + phosphoethanolamine = acetaldehyde + NH(4)(+) + phosphate." [EC:4.2.3.2, RHEA:17892]


id: GO:0050460
name: hydroxylamine reductase (NADH) activity
namespace: molecular_function
def:
  "Catalysis of the reaction: NH3 + NAD+ + H2O = hydroxylamine + NADH + H+." [EC:1.7.1.10, MetaCyc:HYDROXYLAMINE-REDUCTASE-NADH-RXN]


id: GO:0050461
name: L-mimosine synthase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 3,4-dihydroxypyridine + O-acetyl-L-serine = 3-(3,4-dihydroxypyridinium-1-yl)-L-alanine + acetate." [EC:2.5.1.52, RHEA:12696]


id: GO:0050462
name: N-acetylneuraminate synthase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: phosphoenolpyruvate + N-acetyl-D-mannosamine + H2O = phosphate + N-acetylneuraminate." [EC:2.5.1.56, MetaCyc:N-ACETYLNEURAMINATE-SYNTHASE-RXN]


id: GO:0050463
name: nitrate reductase [NAD(P)H] activity
namespace: molecular_function
def:
  "Catalysis of the reaction: nitrite + NAD(P)+ + H2O = nitrate + NAD(P)H + H+." [EC:1.7.1.2, MetaCyc:NITRATE-REDUCTASE-NADPH-RXN]


id: GO:0050464
name: nitrate reductase (NADPH) activity
namespace: molecular_function
def:
  "Catalysis of the reaction: nitrite + NADP+ + H2O = nitrate + NADPH + H+." [EC:1.7.1.3, MetaCyc:NITRATE-REDUCTASE-NADPH-RXN]


id: GO:0050465
name: nitroquinoline-N-oxide reductase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 4-(hydroxyamino)quinoline N-oxide + 2 NAD(P)+ + H2O = 4-nitroquinoline N-oxide + 2 NAD(P)H + 2 H+." [EC:1.7.1.9, MetaCyc:1.7.1.9-RXN]


id: GO:0050466
name: obsolete oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond, with other acceptors
namespace: molecular_function
def:
  "OBSOLETE. Catalysis of an oxidation-reduction (redox) reaction in which X-H and Y-H form X-Y and the acceptor is not disulfide or oxygen." [GOC:ai]


id: GO:0050467
name: pentalenene synthase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate = diphosphate + pentalenene." [EC:4.2.3.7, RHEA:18084]


id: GO:0050468
name: reticuline oxidase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: (S)-reticuline + O(2) = (S)-scoulerine + H(2)O(2) + H(+)." [EC:1.21.3.3, RHEA:19888]


id: GO:0050469
name: sabinene-hydrate synthase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: geranyl diphosphate + H(2)O = diphosphate + sabinene hydrate." [EC:4.2.3.11, RHEA:19568]


id: GO:0050470
name: trimethylamine dehydrogenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: trimethylamine + H2O + electron-transferring flavoprotein = dimethylamine + formaldehyde + reduced electron-transferring flavoprotein." [EC:1.5.8.2, MetaCyc:1.5.8.2-RXN]


id: GO:0050471
name: uracilylalanine synthase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: O3-acetyl-L-serine + uracil = 3-(uracil-1-yl)-L-alanine + acetate." [EC:2.5.1.53, MetaCyc:URACILYLALANINE-SYNTHASE-RXN]


id: GO:0050472
name: zeatin reductase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: dihydrozeatin + NADP(+) = H(+) + NADPH + zeatin." [EC:1.3.1.69, RHEA:12760]


id: GO:0050473
name: arachidonate 15-lipoxygenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: arachidonate + O2 = (5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyicosa-5,8,11,13-tetraenoate." [EC:1.13.11.33]


id: GO:0050474
name: (S)-norcoclaurine synthase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 4-(2-aminoethyl)benzene-1,2-diol + 4-hydroxyphenylacetaldehyde = (S)-norcoclaurine + H2O." [EC:4.2.1.78]


id: GO:0050478
name: anthranilate 3-monooxygenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 5,6,7,8-tetrahydrobiopterin + anthranilate + O(2) = 3-hydroxyanthranilate + 7,8-dihydrobiopterin + H(2)O." [EC:1.14.16.3, RHEA:21171]


id: GO:0050479
name: glyceryl-ether monooxygenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 1-alkyl-sn-glycerol + O2 + (tetrahydrobiopterin/tetrahydropteridine) = 1-hydroxyalkyl-sn-glycerol + H2O + (dihydrobiopterin/dihydropteridine)." [EC:1.14.16.5, MetaCyc:GLYCERYL-ETHER-MONOOXYGENASE-RXN]


id: GO:0050480
name: imidazolonepropionase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: (S)-3-(4-oxo-4,5-dihydro-1H-imidazol-5-yl)propanoic acid + H(2)O = N-formimidoyl-L-glutamate + H(+)." [EC:3.5.2.7, RHEA:23663]


id: GO:0050481
name: mandelate 4-monooxygenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: (S)-mandelate + 5,6,7,8-tetrahydrobiopterin + O(2) = (S)-4-hydroxymandelate + 7,8-dihydrobiopterin + H(2)O. (S)-2-hydroxy-2-phenylacetate is also known as S-mandelate." [EC:1.14.16.6, RHEA:21719]


id: GO:0050485
name: oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond, with a disulfide as acceptor
namespace: molecular_function
def:
  "Catalysis of an oxidation-reduction (redox) reaction in which X-H and Y-H form X-Y and the acceptor is disulfide." [GOC:ai]


id: GO:0050486
name: intramolecular transferase activity, transferring hydroxy groups
namespace: molecular_function
def:
  "Catalysis of the transfer of a hydroxyl group from one position to another within a single molecule." [GOC:mah]


id: GO:0050487
name: sulfoacetaldehyde acetyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: acetyl phosphate + sulfite = phosphate + sulfoacetaldehyde." [EC:2.3.3.15, RHEA:24207]


id: GO:0050488
name: ecdysteroid UDP-glucosyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: UDP-glucose + ecdysteroid = UDP + glucosyl-ecdysteroid." [GOC:ai, PMID:10073711]


id: GO:0050490
name: 1,4-lactonase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: H2O + a 1,4-lactone = a 4-hydroxyacid." [EC:3.1.1.25, MetaCyc:14-LACTONASE-RXN]


id: GO:0050491
name: sulcatone reductase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: NAD(+) + sulcatol = H(+) + NADH + sulcatone." [EC:1.1.1.260, RHEA:24487]


id: GO:0050492
name: glycerol-1-phosphate dehydrogenase [NAD(P)+] activity
namespace: molecular_function
def:
  "Catalysis of the reaction: NAD(P)+ + sn-glycerol-1-phosphate = NAD(P)H + H+ + dihydroxy-acetone-phosphate." [EC:1.1.1.261, MetaCyc:1.1.1.261-RXN]


id: GO:0050493
name: GPI anchor biosynthetic process via N-threonyl-glycosylphosphatidylinositolethanolamine
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of a C-terminal peptidyl-threonyl ethanolamide-linked glycosylphosphatidylinositol (GPI) anchor following hydrolysis of a threonyl-peptide bond in the carboxy-terminal region of a membrane-associated protein." [RESID:AA0164]


id: GO:0050494
name: GSI anchor biosynthetic process via N-glycyl-glycosylsphingolipidinositolethanolamine
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of a C-terminal peptidyl-glycine ethanolamide-linked glycosylsphingolipidinositol (GSI) anchor following hydrolysis of a glycyl-peptide bond in the carboxy-terminal region of a membrane-associated protein." [RESID:AA0165]


id: GO:0050495
name: peptidyl-glycyl-phosphatidylethanolamine biosynthetic process from peptidyl-glycine
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of a C-terminal peptidyl-glycine ethanolamide-linked phosphatide following hydrolysis of a glycyl-peptide bond, as in the cleavage of arginine from the carboxy-terminal of Apg8 followed by its amidation with phosphatidylethanolamine." [RESID:AA0346]


id: GO:0050496
name: peptidyl-L-glutamyl 5-omega-hydroxyceramide ester biosynthetic process from peptidyl-glutamine
namespace: biological_process
def:
  "The modification of peptidyl-glutamine residues by deamidation and esterification with omega-hydroxyceramide." [PMID:10411887, RESID:AA0347]


id: GO:0050497
name: transferase activity, transferring alkylthio groups
namespace: molecular_function
def:
  "Catalysis of the transfer of an alkylthio group from one compound (donor) to another (acceptor)." [GOC:ai]


id: GO:0050498
namespace: molecular_function
name:
  oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, with 2-oxoglutarate as one donor, and the other dehydrogenated

def:
  "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from 2-oxoglutarate and one other donor, and the latter donor is dehydrogenated." [GOC:mah]


id: GO:0050499
name: oxidoreductase activity, acting on phosphorus or arsenic in donors, with NAD(P)+ as acceptor
namespace: molecular_function
def:
  "Catalysis of an oxidation-reduction (redox) reaction in which a phosphorus- or arsenic-containing group acts as a hydrogen or electron donor and reduces a NAD(P)+ to NAD(P)H." [GOC:mah]


id: GO:0050500
name: 1,3-beta-galactosyl-N-acetylhexosamine phosphorylase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: phosphate + beta-D-galactopyranosyl-(1->3)-N-acetyl-D-glucosamine = N-acetyl-D-glucosamine + alpha-D-galactopyranose 1-phosphate." [EC:2.4.1.211, MetaCyc:2.4.1.211-RXN]


id: GO:0050501
name: hyaluronan synthase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: UDP-D-glucuronate + UDP-N-acetyl-D-glucosamine = [beta-N-acetyl-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)](n) + 2n UDP." [EC:2.4.1.212, MetaCyc:2.4.1.212-RXN]


id: GO:0050502
name: cis-zeatin O-beta-D-glucosyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: cis-zeatin + UDP-D-glucose = O-beta-D-glucosyl-cis-zeatin + H(+) + UDP." [EC:2.4.1.215, RHEA:20684]


id: GO:0050503
name: trehalose 6-phosphate phosphorylase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: trehalose 6-phosphate + phosphate = glucose 6-phosphate + beta-D-glucose 1-phosphate." [EC:2.4.1.216, MetaCyc:2.4.1.216-RXN]


id: GO:0050504
name: mannosyl-3-phosphoglycerate synthase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 3-phospho-D-glycerate + GDP-alpha-D-mannose = 2-(alpha-D-mannosyl)-3-phosphoglycerate + GDP + H(+)." [EC:2.4.1.217, RHEA:13540]


id: GO:0050505
name: hydroquinone glucosyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: hydroquinone + UDP-D-glucose = H(+) + hydroquinone O-beta-D-glucopyranoside + UDP." [EC:2.4.1.218, RHEA:12563]


id: GO:0050506
name: vomilenine glucosyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: UDP-D-glucose + vomilenine = H(+) + raucaffricine + UDP." [EC:2.4.1.219, RHEA:19388]


id: GO:0050507
name: indoxyl-UDPG glucosyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: indoxyl + UDP-D-glucose = H(+) + indican + UDP." [EC:2.4.1.220, RHEA:12007]


id: GO:0050508
name: glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: beta-D-glucuronosyl-(1,4)-N-acetyl-alpha-D-glucosaminyl-proteoglycan + UDP-N-acetyl-D-glucosamine = N-acetyl-alpha-D-glucosaminyl-(1,4)-beta-D-glucuronosyl-(1,4)-N-acetyl-alpha-D-glucosaminyl-proteoglycan + UDP." [EC:2.4.1.224, MetaCyc:2.4.1.224-RXN]


id: GO:0050509
name: N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: N-acetyl-alpha-D-glucosaminyl-(1,4)-beta-D-glucuronosyl-proteoglycan + UDP-alpha-D-glucuronate = beta-D-glucuronosyl-(1,4)-N-acetyl-alpha-D-glucosaminyl-(1,4)-beta-D-glucuronosyl-proteoglycan + UDP." [EC:2.4.1.225, MetaCyc:2.4.1.225-RXN]


id: GO:0050510
name: N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: N-acetyl-beta-D-galactosaminyl-(1,4)-beta-D-glucuronosyl-proteoglycan + UDP-alpha-D-glucuronate = beta-D-glucuronosyl-(1,3)-N-acetyl-beta-D-galactosaminyl-(1,4)-beta-D-glucuronosyl-proteoglycan + UDP." [EC:2.4.1.226, MetaCyc:2.4.1.226-RXN]


id: GO:0050511
name: undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol + UDP-N-acetyl-D-glucosamine = GlcNAc-(1,4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol + UDP." [EC:2.4.1.227, MetaCyc:2.4.1.227-RXN]


id: GO:0050512
name: lactosylceramide 4-alpha-galactosyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: beta-D-galactosyl-(1,4)-D-glucosylceramide + UDP-galactose = alpha-D-galactosyl-(1,4)-beta-D-galactosyl-(1,4)-D-glucosylceramide + UDP." [EC:2.4.1.228, MetaCyc:2.4.1.228-RXN]


id: GO:0050513
name: glycoprotein 2-beta-D-xylosyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: N(4)-{N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)]-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl}-L-asparagine + UDP-alpha-D-xylose = N(4)-{N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)]-[beta-D-xylosyl-(1->2)]-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl}-L-asparagine + H(+) + UDP." [EC:2.4.2.38, RHEA:10615]


id: GO:0050514
name: homospermidine synthase (spermidine-specific) activity
namespace: molecular_function
def:
  "Catalysis of the reaction: spermidine + putrescine = sym-homospermidine + propane-1,3-diamine." [EC:2.5.1.45, MetaCyc:2.5.1.45-RXN]


id: GO:0050515
name: 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 4-CDP-2-C-methyl-D-erythritol + ATP = 4-CDP-2-C-methyl-D-erythritol 2-phosphate + ADP + 2 H(+)." [EC:2.7.1.148, RHEA:18440]


id: GO:0050516
name: obsolete inositol polyphosphate multikinase activity
namespace: molecular_function
def:
  "OBSOLETE. Catalysis of the reactions: ATP + 1D-myo-inositol 1,4,5-trisphosphate = ADP + 1D-myo-inositol 1,4,5,6-tetrakisphosphate, and ATP + 1D-myo-inositol 1,4,5,6-tetrakisphosphate = ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate." [EC:2.7.1.151, MetaCyc:2.7.1.151-RXN]


id: GO:0050517
name: obsolete inositol hexakisphosphate kinase activity
namespace: molecular_function
def:
  "OBSOLETE. Catalysis of the reactions: ATP + 1D-myo-inositol hexakisphosphate = ADP + 5-diphospho-1D-myo-inositol (1,2,3,4,6)pentakisphosphate, and ATP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate = ADP + diphospho-1D-myo-inositol tetrakisphosphate (isomeric configuration unknown)." [EC:2.7.4.21, MetaCyc:2.7.4.21-RXN]


id: GO:0050518
name: 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 2-C-methyl-D-erythritol 4-phosphate + CTP = 4-CDP-2-C-methyl-D-erythritol + diphosphate." [EC:2.7.7.60, RHEA:13432]


id: GO:0050519
name: holo-citrate lyase synthase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: apo-citrate lyase + 2'-(5''-triphosphoribosyl)-3'-dephospho-CoA = diphosphate + holo-citrate lyase." [EC:2.7.7.61, MetaCyc:2.7.7.61-RXN]


id: GO:0050520
name: phosphatidylcholine synthase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: CDP-diacylglycerol + choline = 1,2-diacyl-sn-glycero-3-phosphocholine + CMP + H(+)." [EC:2.7.8.24, RHEA:14600]


id: GO:0050521
name: alpha-glucan, water dikinase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: ATP + alpha-glucan + H2O = AMP + phospho-alpha-glucan + phosphate." [EC:2.7.9.4, MetaCyc:2.7.9.4-RXN]


id: GO:0050522
name: oxidoreductase activity, acting on phosphorus or arsenic in donors, with other known acceptors
namespace: molecular_function
def:
  "Catalysis of an oxidation-reduction (redox) reaction in which phosphorus or arsenic acts as a hydrogen or electron donor and reduces a known acceptor other than disulfide, NAD or NADP." [GOC:ai]


id: GO:0050523
name: obsolete oxidoreductase activity, acting on phosphorus or arsenic in donors, with other acceptors
namespace: molecular_function
def:
  "OBSOLETE. Catalysis of an oxidation-reduction (redox) reaction in which phosphorus or arsenic acts as a hydrogen or electron donor and reduces an acceptor other than disulfide, NAD or NADP." [GOC:ai]


id: GO:0050524
name: coenzyme-B sulfoethylthiotransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: coenzyme B + methyl-coenzyme M = coenzyme M-coenzyme B heterodisulfide + methane. Methyl-CoM is also known as 2-(methylthio)ethanesulfonate, coenzyme B as N-(7-mercaptoheptanoyl)threonine 3-O-phosphate, and coenzyme M-coenzyme B heterodisulfide as CoM-S-S-CoB." [EC:2.8.4.1, RHEA:12535]


id: GO:0050526
name: poly(3-hydroxybutyrate) depolymerase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: H2O + poly[(R)-3-hydroxybutanoate](n) = poly[(R)-3-hydroxybutanoate](x) + poly[(R)-3-hydroxybutanoate](n-x); x is 1-5." [EC:3.1.1.75, MetaCyc:3.1.1.75-RXN]


id: GO:0050527
name: poly(3-hydroxyoctanoate) depolymerase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: H2O + poly[(R)-3-hydroxyoctanoate](n) = poly[(R)-3-hydroxyoctanoate](x) + poly[(R)-3-hydroxyoctanoate](n-x); x is 1-5." [EC:3.1.1.76, MetaCyc:3.1.1.76-RXN]


id: GO:0050528
name: acyloxyacyl hydrolase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 3-(acyloxy)acyl group of bacterial toxin = 3-hydroxyacyl group of bacterial toxin + a fatty acid." [EC:3.1.1.77, MetaCyc:3.1.1.77-RXN]


id: GO:0050529
name: polyneuridine-aldehyde esterase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: H(2)O + polyneuridine aldehyde = 16-epivellosimine + CO(2) + methanol." [EC:3.1.1.78, RHEA:17504]


id: GO:0050530
name: glucosylglycerol 3-phosphatase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 2-O-(beta-D-glucosyl)-sn-glycerol 3-phosphate + H(2)O = 2-O-(beta-D-glucosyl)-sn-glycerol + phosphate." [EC:3.1.3.69, RHEA:22655]


id: GO:0050531
name: mannosyl-3-phosphoglycerate phosphatase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 2-(alpha-D-mannosyl)-3-phosphoglycerate + H(2)O = 2-(alpha-D-mannosyl)-D-glycerate + phosphate." [EC:3.1.3.70, RHEA:19312]


id: GO:0050532
name: 2-phosphosulfolactate phosphatase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: (2R)-O-phospho-3-sulfolactate + H(2)O = (R)-3-sulfolactate + phosphate." [EC:3.1.3.71, RHEA:23419]


id: GO:0050533
name: 5-phytase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: H2O + myo-inositol hexakisphosphate = phosphate + 1L-myo-inositol 1,2,3,4,6-pentakisphosphate." [EC:3.1.3.72, MetaCyc:3.1.3.72-RXN]


id: GO:0050534
name: 3-deoxyoctulosonase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 3-deoxyoctulosonyl-lipopolysaccharide + H2O = 3-deoxyoctulosonic acid + lipopolysaccharide." [EC:3.2.1.144, MetaCyc:3.2.1.144-RXN]


id: GO:0050535
name: beta-primeverosidase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: a 6-O-(beta-D-xylopyranosyl)-beta-D-glucopyranoside + H2O = 6-O-(beta-D-xylopyranosyl)-beta-D-glucopyranose + an alcohol." [EC:3.2.1.149, MetaCyc:3.2.1.149-RXN]


id: GO:0050536
name: (S)-N-acetyl-1-phenylethylamine hydrolase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: N-acetylphenylethylamine + H(2)O = acetate + phenylethylamine." [EC:3.5.1.85, RHEA:23955]


id: GO:0050537
name: mandelamide amidase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: (R)-mandelamide + H(2)O = (R)-mandelate + NH(4)(+)." [EC:3.5.1.86, RHEA:22879]


id: GO:0050538
name: N-carbamoyl-L-amino-acid hydrolase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: N-carbamoyl-L-2-amino acid + H2O = L-2-amino acid + NH3 + CO2. The N-carbamoyl-L-2-amino acid is a 2-ureido carboxylate." [EC:3.5.1.87, MetaCyc:3.5.1.87-RXN]


id: GO:0050540
name: 2-aminomuconate deaminase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 2-aminomuconate + H(2)O + H(+) = (Z)-5-oxohex-2-enedioate + NH(4)(+)." [EC:3.5.99.5, RHEA:20999]


id: GO:0050541
name: beta,beta-carotene-9',10'-dioxygenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: beta-carotene + O2 = beta-apo-10'-carotenal + beta-ionone." [PMID:11278918]


id: GO:0050542
name: icosanoid binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with icosanoids, any C20 polyunsaturated fatty acids or their derivatives, including the leukotrienes and the prostanoids." [ISBN:0198506732]


id: GO:0050543
name: icosatetraenoic acid binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with icosatetraenoic acid, any straight-chain fatty acid with twenty carbon atoms and four double bonds per molecule." [ISBN:0198506732]


id: GO:0050544
name: arachidonic acid binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with arachidonic acid, a straight chain fatty acid with 20 carbon atoms and four double bonds per molecule. Arachidonic acid is the all-Z-(5,8,11,14)-isomer." [GOC:ai]


id: GO:0050545
name: sulfopyruvate decarboxylase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 3-sulfopyruvate + H(+) = CO(2) + sulfoacetaldehyde." [EC:4.1.1.79, RHEA:20951]


id: GO:0050546
name: 4-hydroxyphenylpyruvate decarboxylase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: (4-hydroxyphenyl)pyruvate + H(+) = (4-hydroxyphenyl)acetaldehyde + CO(2)." [EC:4.1.1.80, RHEA:18700]


id: GO:0050547
name: vanillin synthase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 3-hydroxy-3-(4-hydroxy-3-methoxyphenyl)propanoyl-CoA = acetyl-CoA + vanillin." [EC:4.1.2.41, RHEA:18728]


id: GO:0050548
name: trans-feruloyl-CoA hydratase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: trans-feruloyl-CoA + H2O = 4-hydroxy-3-methoxyphenyl-beta-hydroxypropionyl-CoA." [EC:4.2.1.101, MetaCyc:4.2.1.101-RXN]


id: GO:0050549
name: cyclohexyl-isocyanide hydratase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: N-cyclohexylformamide + H(+) = cyclohexyl isocyanide + H(2)O." [EC:4.2.1.103, RHEA:18200]


id: GO:0050550
name: pinene synthase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: geranyl diphosphate = pinene + diphosphate." [EC:4.2.3.14, MetaCyc:4.2.3.14-RXN]


id: GO:0050552
name: (4S)-limonene synthase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: geranyl diphosphate = (4S)-limonene + diphosphate." [EC:4.2.3.16, MetaCyc:4.2.3.16-RXN]


id: GO:0050553
name: taxadiene synthase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: all-trans-geranylgeranyl diphosphate = diphosphate + taxa-4,11-diene." [EC:4.2.3.17, RHEA:20915]


id: GO:0050554
name: abietadiene synthase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: (+)-copalyl diphosphate = (-)-abietadiene + diphosphate." [EC:4.2.3.18, RHEA:13876]


id: GO:0050555
name: 2-hydroxypropyl-CoM lyase activity
namespace: molecular_function
def:
  "Catalysis of the reactions: (R)-2-hydroxypropyl-CoM = H-S-CoM + (R)-1,2-epoxypropane, and (S)-2-hydroxypropyl-CoM = H-S-CoM + (S)-1,2-epoxypropane." [EC:4.2.99.19, MetaCyc:4.2.99.19-RXN]


id: GO:0050556
name: deacetylisoipecoside synthase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: deacetylisoipecoside + H(2)O = dopamine + secologanin." [EC:4.3.3.3, RHEA:21759]


id: GO:0050557
name: deacetylipecoside synthase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: deacetylipecoside + H(2)O = dopamine + secologanin." [EC:4.3.3.4, RHEA:12299]


id: GO:0050559
name: copalyl diphosphate synthase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: all-trans-geranylgeranyl diphosphate = (+)-copalyl diphosphate." [EC:5.5.1.12, RHEA:24319]


id: GO:0050560
name: aspartate-tRNA(Asn) ligase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: tRNA(Asx) + L-aspartate + ATP = aspartyl-tRNA(Asx) + diphosphate + AMP." [EC:6.1.1.23, MetaCyc:6.1.1.23-RXN]


id: GO:0050561
name: glutamate-tRNA(Gln) ligase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: tRNA(Glx) + L-glutamate + ATP = glutamyl-tRNA(Glx) + diphosphate + AMP." [EC:6.1.1.24, MetaCyc:6.1.1.24-RXN]


id: GO:0050562
name: lysine-tRNA(Pyl) ligase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: tRNA(Pyl) + L-lysine + ATP = L-lysyl-tRNA(Pyl) + diphosphate + AMP." [EC:6.1.1.25, MetaCyc:6.1.1.25-RXN]


id: GO:0050563
name: trans-feruloyl-CoA synthase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: ferulic acid + CoASH + ATP = trans-feruloyl-CoA + products of ATP breakdown." [EC:6.2.1.34, MetaCyc:6.2.1.34-RXN]


id: GO:0050564
name: N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine synthase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: L-2-aminoadipate + L-cysteine + L-valine + 3 ATP + H(2)O = N-[(5S)-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine + 3 AMP + 3 diphosphate + 6 H(+)." [EC:6.3.2.26, RHEA:23199]


id: GO:0050565
name: aerobactin synthase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 2 N(6)-acetyl-N(6)-hydroxy-L-lysine + 4 ATP + citrate + 2 H(2)O = 4 ADP + aerobactin + 8 H(+) + 4 phosphate." [EC:6.3.2.27, RHEA:11763]


id: GO:0050566
name: asparaginyl-tRNA synthase (glutamine-hydrolyzing) activity
namespace: molecular_function
def:
  "Catalysis of the reaction: L-glutamine + aspartyl-tRNA(Asn) + ATP = L-glutamate + asparaginyl-tRNA(Asn) + phosphate + ADP." [EC:6.3.5.6, MetaCyc:6.3.5.6-RXN]


id: GO:0050567
name: glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity
namespace: molecular_function
def:
  "Catalysis of the reaction: L-glutamine + glutamyl-tRNA(Gln) + ATP = L-glutamate + glutaminyl-tRNA(Gln) + phosphate + ADP." [EC:6.3.5.7, MetaCyc:6.3.5.7-RXN]


id: GO:0050568
name: protein-glutamine glutaminase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: protein L-glutamine + H2O = protein L-glutamate + NH3." [EC:3.5.1.44, MetaCyc:CHEBDEAMID-RXN]


id: GO:0050569
name: glycolaldehyde dehydrogenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: glycolaldehyde + H(2)O + NAD(+) = glycolate + 2 H(+) + NADH." [EC:1.2.1.21, RHEA:20004]


id: GO:0050570
name: 4-hydroxythreonine-4-phosphate dehydrogenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 4-(phosphonooxy)-threonine + NAD+ = 2-amino-3-oxo-4-phosphonooxybutyrate + NADH + H+." [EC:1.1.1.262, MetaCyc:1.1.1.262-RXN]


id: GO:0050571
name: 1,5-anhydro-D-fructose reductase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 1,5-anhydro-D-glucitol + NADP(+) = 1,5-anhydro-D-fructose + H(+) + NADPH." [EC:1.1.1.263, RHEA:20668]


id: GO:0050572
name: L-idonate 5-dehydrogenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: L-idonate + NAD(P)+ = 5-dehydrogluconate + NAD(P)H + H+." [EC:1.1.1.264, MetaCyc:1.1.1.264-RXN]


id: GO:0050573
name: dTDP-4-dehydro-6-deoxyglucose reductase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: dTDP-D-fucose + NADP(+) = dTDP-4-dehydro-6-deoxy-alpha-D-glucose + H(+) + NADPH." [EC:1.1.1.266, RHEA:21903]


id: GO:0050574
name: 2-(R)-hydroxypropyl-CoM dehydrogenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 2-(R)-hydroxypropyl-coenzyme M + NAD(+) = 2-oxopropyl-coenzyme M + H(+) + NADH." [EC:1.1.1.268, RHEA:13252]


id: GO:0050575
name: 2-(S)-hydroxypropyl-CoM dehydrogenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 2-(S)-hydroxypropyl-coenzyme M + NAD(+) = 2-oxopropyl-coenzyme M + H(+) + NADH." [EC:1.1.1.269, RHEA:21055]


id: GO:0050577
name: GDP-L-fucose synthase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: GDP-L-fucose + NAD+ = GDP-4-dehydro-6-deoxy-D-mannose + NADH + H+." [EC:1.1.1.271, MetaCyc:1.1.1.271-RXN]


id: GO:0050578
name: (R)-2-hydroxyacid dehydrogenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: (S)-3-sulfolactate + NAD(P)+ = 3-sulfopyruvate + NAD(P)H + H+." [EC:1.1.1.272, MetaCyc:1.1.1.272-RXN]


id: GO:0050579
name: vellosimine dehydrogenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 10-deoxysarpagine + NADP(+) = H(+) + NADPH + vellosimine." [EC:1.1.1.273, RHEA:20032]


id: GO:0050580
name: 2,5-didehydrogluconate reductase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 2-dehydro-D-gluconate + NADP+ = 2,5-didehydro-D-gluconate + NADPH + H+." [EC:1.1.1.274, MetaCyc:1.1.1.274-RXN]


id: GO:0050584
name: linoleate 11-lipoxygenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: linoleate + O(2) = (9Z,11S,12Z)-11-hydroperoxyoctadeca-9,12-dienoate." [EC:1.13.11.45, RHEA:18996]


id: GO:0050585
name: 4-hydroxymandelate synthase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 4-hydroxyphenylpyruvate + O2 = 4-hydroxymandelate + CO2." [EC:1.13.11.46, MetaCyc:1.13.11.46-RXN]


id: GO:0050586
name: 3-hydroxy-2-methylquinolin-4-one 2,4-dioxygenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 3-hydroxy-2-methylquinolin-4(1H)-one + H(+) + O(2) = N-acetylanthranilate + CO." [EC:1.13.11.48, RHEA:21575]


id: GO:0050588
name: apo-beta-carotenoid-14',13'-dioxygenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 8'-apo-beta-carotenol + O(2) = (E,E)-7-hydroxy-6-methylhepta-3,5-dienal + 14'-apo-beta-carotenal." [EC:1.13.12.12, RHEA:26026]


id: GO:0050589
name: leucocyanidin oxygenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: leucocyanidin + 2-oxoglutarate + O2 = cis- or trans-dihydroquercetin + succinate + CO2 + 2 H2O." [EC:1.14.11.19, MetaCyc:1.14.11.19-RXN]


id: GO:0050590
name: desacetoxyvindoline 4-hydroxylase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: desacetoxyvindoline + 2-oxoglutarate + O2 = desacetylvindoline + succinate + CO2." [EC:1.14.11.20, MetaCyc:1.14.11.20-RXN]


id: GO:0050591
name: quinine 3-monooxygenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: H(+) + NADPH + O(2) + quinine = 3-hydroxyquinine + H(2)O + NADP(+)." [EC:1.14.13.67, RHEA:20152]


id: GO:0050592
name: 4-hydroxyphenylacetaldehyde oxime monooxygenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: (Z)-(4-hydroxyphenyl)acetaldehyde oxime + H(+) + NADPH + O(2) = (S)-4-hydroxymandelonitrile + 2 H(2)O + NADP(+)." [EC:1.14.13.68, RHEA:18404]


id: GO:0050593
name: N-methylcoclaurine 3'-monooxygenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: (S)-N-methylcoclaurine + H(+) + NADPH + O(2) = (S)-3'-hydroxy-N-methylcoclaurine + H(2)O + NADP(+)." [EC:1.14.13.71, RHEA:16652]


id: GO:0050594
name: tabersonine 16-hydroxylase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: H(+) + NADPH + O(2) + tabersonine = 16-hydroxytabersonine + H(2)O + NADP(+)." [EC:1.14.13.73, RHEA:14136]


id: GO:0050595
name: 7-deoxyloganin 7-hydroxylase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 7-deoxyloganin + NADPH + H+ + O2 = loganin + NADP+ + H2O." [EC:1.14.13.74, MetaCyc:1.14.13.74-RXN]


id: GO:0050596
name: vinorine hydroxylase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: H(+) + NADPH + O(2) + vinorine = H(2)O + NADP(+) + vomilenine." [EC:1.14.13.75, RHEA:17260]


id: GO:0050597
name: taxane 10-beta-hydroxylase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: H(+) + NADPH + O(2) + taxa-4(20),11-dien-5alpha-yl acetate = 10beta-hydroxytaxa-4(20),11-dien-5alpha-yl acetate + H(2)O + NADP(+)." [EC:1.14.13.76, RHEA:15244]


id: GO:0050598
name: taxane 13-alpha-hydroxylase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: H(+) + NADPH + O(2) + taxa-4(20),11-dien-5alpha-ol = H(2)O + NADP(+) + taxa-4(20),11-dien-5alpha,13alpha-diol." [EC:1.14.13.77, RHEA:18952]


id: GO:0050599
name: deacetoxycephalosporin-C synthase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 2-oxoglutarate + O(2) + penicillin N = CO(2) + deacetoxycephalosporin C + H(2)O + succinate." [EC:1.14.20.1, RHEA:20751]


id: GO:0050600
name: myristoyl-CoA 11-(E) desaturase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: myristoyl-CoA + NAD(P)H + H+ + O2 = (E)-11-tetradecenoyl-CoA + NAD(P)+ + 2 H2O." [EC:1.14.99.31, MetaCyc:1.14.99.31-RXN]


id: GO:0050601
name: myristoyl-CoA 11-(Z) desaturase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: myristoyl-CoA + NAD(P)H + H+ + O2 = (Z)-11-tetradecenoyl-CoA + NAD(P)+ + 2 H2O." [EC:1.14.99.32, MetaCyc:1.14.99.32-RXN]


id: GO:0050602
name: monoprenyl isoflavone epoxidase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: O2 + NADPH + H+ + 7-O-methylluteone = H2O + NADP+ + dihydrofurano derivatives." [EC:1.14.99.34, MetaCyc:1.14.99.34-RXN]


id: GO:0050603
name: thiophene-2-carbonyl-CoA monooxygenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: AH(2) + O(2) + thiophene-2-carbonyl-CoA = 5-hydroxythiophene-2-carbonyl-CoA + A + H(2)O + H(+)." [EC:1.14.99.35, RHEA:18932]


id: GO:0050604
name: taxadiene 5-alpha-hydroxylase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: AH(2) + O(2) + taxa-4,11-diene = A + H(2)O + taxa-4(20),11-dien-5alpha-ol." [EC:1.14.99.37, RHEA:14052]


id: GO:0050605
name: superoxide reductase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: superoxide + reduced rubredoxin + 2 H+ = H2O2 + rubredoxin." [EC:1.15.1.2, MetaCyc:1.15.1.2-RXN]


id: GO:0050606
name: 4-carboxy-2-hydroxymuconate semialdehyde hemiacetal dehydrogenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 4-carboxy-2-hydroxymuconate semialdehyde hemiacetal + NADP(+) = 2-oxo-2H-pyran-4,6-dicarboxylate + H(+) + NADPH." [RHEA:29590]


id: GO:0050607
name: mycothiol-dependent formaldehyde dehydrogenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: formaldehyde + mycothiol + NAD+ = S-formylmycothiol + NADH + H+." [EC:1.2.1.66, MetaCyc:1.2.1.66-RXN]


id: GO:0050608
name: vanillin dehydrogenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: H(2)O + NAD(+) + vanillin = 2 H(+) + NADH + vanillate." [EC:1.2.1.67, RHEA:13312]


id: GO:0050609
name: phosphonate dehydrogenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: H(2)O + NAD(+) + phosphonate = 2 H(+) + NADH + phosphate." [EC:1.20.1.1, RHEA:13176]


id: GO:0050610
name: methylarsonate reductase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 2 glutathione + H(+) + methylarsonate = glutathione disulfide + H(2)O + methylarsonous acid." [EC:1.20.4.2, RHEA:15972]


id: GO:0050611
name: arsenate reductase (azurin) activity
namespace: molecular_function
def:
  "Catalysis of the reaction: H(2)O + arsenite + 2 oxidized azurin = 2 H(+) + 2 reduced azurin + arsenate." [EC:1.20.9.1, MetaCyc:1.20.98.1-RXN]


id: GO:0050612
name: arsenate reductase (donor) activity
namespace: molecular_function
def:
  "Catalysis of the reaction: A + arsenite + H(2)O = AH(2) + arsenate + 2 H(+)." [EC:1.20.99.1, RHEA:18452]


id: GO:0050613
name: delta14-sterol reductase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: NADP+ + 4,4-dimethyl-5-alpha-cholesta-8,24-dien-3-beta-ol = NADPH + H+ + 4,4-dimethyl-5-alpha-cholesta-8,14,24-trien-3-beta-ol." [EC:1.3.1.70, MetaCyc:1.3.1.70-RXN]


id: GO:0050614
name: delta24-sterol reductase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: NADP+ + 5-alpha-cholest-7-en-3-beta-ol = NADPH + H+ + 5-alpha-cholesta-7,24-dien-3-beta-ol." [EC:1.3.1.72, MetaCyc:1.3.1.72-RXN]


id: GO:0050615
name: 1,2-dihydrovomilenine reductase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 17-O-acetylnorajmaline + NADP(+) = 1,2-dihydrovomilenine + H(+) + NADPH." [EC:1.3.1.73, RHEA:12323]


id: GO:0050616
name: secologanin synthase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: loganin + NADPH + H+ + O2 = secologanin + NADP+ + 2 H2O." [EC:1.3.3.9, MetaCyc:1.3.3.9-RXN]


id: GO:0050617
name: 15,16-dihydrobiliverdin:ferredoxin oxidoreductase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 15,16-dihydrobiliverdin + oxidized ferredoxin = biliverdin IXa + reduced ferredoxin." [EC:1.3.7.2, MetaCyc:1.3.7.2-RXN]


id: GO:0050618
name: phycoerythrobilin:ferredoxin oxidoreductase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: (3Z)-phycoerythrobilin + oxidized ferredoxin = 15,16-dihydrobiliverdin + reduced ferredoxin." [EC:1.3.7.3, MetaCyc:1.3.7.3-RXN]


id: GO:0050619
name: phytochromobilin:ferredoxin oxidoreductase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: (3Z)-phytochromobilin + oxidized ferredoxin = biliverdin IXa + reduced ferredoxin." [EC:1.3.7.4, MetaCyc:1.3.7.4-RXN]


id: GO:0050620
name: phycocyanobilin:ferredoxin oxidoreductase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: (3Z)-phycocyanobilin + oxidized ferredoxin = biliverdin IXa + reduced ferredoxin." [EC:1.3.7.5, MetaCyc:1.3.7.5-RXN]


id: GO:0050621
name: tryptophan alpha,beta-oxidase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: L-tryptophan + O(2) = alpha,beta-didehydrotryptophan + H(2)O(2) + H(+)." [EC:1.3.3.10, RHEA:19904]


id: GO:0050623
name: berberine reductase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: (R)-canadine + 2 NADP(+) = berberine + H(+) + 2 NADPH." [EC:1.5.1.31, RHEA:21271]


id: GO:0050624
name: vomilenine reductase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 1,2-dihydrovomilenine + NADP(+) = H(+) + NADPH + vomilenine." [EC:1.5.1.32, RHEA:16412]


id: GO:0050625
name: 2-hydroxy-1,4-benzoquinone reductase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 2-hydroxy-1,4-benzoquinone + 2 H(+) + NADH = benzene-1,2,4-triol + NAD(+)." [EC:1.6.5.7, RHEA:12431]


id: GO:0050626
name: trimethylamine-N-oxide reductase (cytochrome c) activity
namespace: molecular_function
def:
  "Catalysis of the reaction: trimethylamine + 2 (ferricytochrome c)-subunit + H2O = trimethylamine-N-oxide + 2 (ferrocytochrome c)-subunit + 2 H+." [EC:1.7.2.3, MetaCyc:1.7.2.3-RXN]


id: GO:0050627
name: mycothione reductase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: NAD(P)+ + mycothiol = NAD(P)H + H+ + mycothione." [EC:1.8.1.15, MetaCyc:1.8.1.15-RXN]


id: GO:0050628
name: 2-oxopropyl-CoM reductase (carboxylating) activity
namespace: molecular_function
def:
  "Catalysis of the reaction: acetoacetate + coenzyme M + NADP(+) = 2-oxopropyl-coenzyme M + CO(2) + NADPH." [EC:1.8.1.5, RHEA:16980]


id: GO:0050629
name: tetrachloroethene reductive dehalogenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: trichloroethene + chloride + acceptor = tetrachloroethene + reduced acceptor." [EC:1.97.1.8, MetaCyc:1.97.1.8-RXN]


id: GO:0050630
name: (iso)eugenol O-methyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: S-adenosyl-L-methionine + isoeugenol = S-adenosyl-L-homocysteine + isomethyleugenol." [EC:2.1.1.146, MetaCyc:2.1.1.146-RXN]


id: GO:0050631
name: corydaline synthase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: S-adenosyl-L-methionine + 2 NADPH + palmatine = S-adenosyl-L-homocysteine + corydaline + 2 NADP(+)." [EC:2.1.1.147, RHEA:14776]


id: GO:0050632
name: propionyl-CoA C2-trimethyltridecanoyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 4,8,12-trimethyltridecanoyl-CoA + propanoyl-CoA = 3-oxopristanoyl-CoA + CoA." [EC:2.3.1.154, RHEA:10411]


id: GO:0050633
name: acetyl-CoA C-myristoyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: myristoyl-CoA + acetyl-CoA = 3-oxopalmitoyl-CoA + CoA." [EC:2.3.1.155, MetaCyc:2.3.1.155-RXN]


id: GO:0050634
name: phloroisovalerophenone synthase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: isovaleryl-CoA + 3 malonyl-CoA = 4 CoASH + 3 CO2 + 3-methyl-1-(2,4,6-trihydroxyphenyl)butan-1-one." [EC:2.3.1.156, MetaCyc:2.3.1.156-RXN]


id: GO:0050635
name: acridone synthase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: N-methylanthranilyl-CoA + 3 H(+) + 3 malonyl-CoA = 1,3-dihydroxy-N-methylacridone + 3 CO(2) + 4 CoA + H(2)O." [EC:2.3.1.159, RHEA:22227]


id: GO:0050636
name: vinorine synthase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 16-epivellosimine + acetyl-CoA = CoA + vinorine." [EC:2.3.1.160, RHEA:24019]


id: GO:0050637
name: lovastatin nonaketide synthase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: S-adenosyl-L-methionine(1+) + acetyl-CoA + 18 H(+) + 8 malonyl-CoA + 11 NADPH = S-adenosyl-L-homocysteine + 8 CO(2) + 9 CoA + dihydromonacolin L + 6 H(2)O + 11 NADP(+)." [EC:2.3.1.161, RHEA:18568]


id: GO:0050638
name: taxadien-5-alpha-ol O-acetyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: acetyl-CoA + taxa-4(20),11-dien-5alpha-ol = CoA + taxa-4(20),11-dien-5alpha-yl acetate." [EC:2.3.1.162, RHEA:22031]


id: GO:0050639
name: 10-hydroxytaxane O-acetyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 10-desacetyltaxuyunnanin C + acetyl-CoA = CoA + taxuyunnanin C." [EC:2.3.1.163, RHEA:18840]


id: GO:0050640
name: isopenicillin-N N-acyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: phenylacetyl-CoA + isopenicillin N + H2O = CoA + penicillin G + L-2-aminohexanedioate." [EC:2.3.1.164, MetaCyc:2.3.1.164-RXN]


id: GO:0050641
name: 6-methylsalicylic acid synthase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: acetyl-CoA + 3 H(+) + 3 malonyl-CoA + NADPH = 6-methylsalicylate + 3 CO(2) + 4 CoA + H(2)O + NADP(+)." [EC:2.3.1.165, RHEA:12243]


id: GO:0050642
name: 2-alpha-hydroxytaxane 2-O-benzoyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 10-deacetyl-2-debenzoylbaccatin III + benzoyl-CoA = 10-deacetylbaccatin III + CoA." [EC:2.3.1.166, RHEA:18744]


id: GO:0050643
name: 10-deacetylbaccatin III 10-O-acetyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 10-deacetylbaccatin III + acetyl-CoA = baccatin III + CoA." [EC:2.3.1.167, RHEA:20140]


id: GO:0050644
name: cis-p-coumarate glucosyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: cis-4-coumarate + UDP-D-glucose = 4'-O-beta-D-glucosyl-cis-4-coumarate + H(+) + UDP." [EC:2.4.1.209, RHEA:13132]


id: GO:0050646
name: 5-oxo-6E,8Z,11Z,14Z-icosatetraenoic acid binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with 5-oxo-6E,8Z,11Z,14Z-icosatetraenoic acid, a straight-chain fatty acid with twenty carbon atoms and four double bonds." [GOC:ai]


id: GO:0050647
name: 5-hydroxy-6E,8Z,11Z,14Z-icosatetraenoic acid binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with 5-hydroxy-6E,8Z,11Z,14Z-icosatetraenoic acid, a straight-chain fatty acid with twenty carbon atoms and four double bonds." [GOC:ai]


id: GO:0050648
name: 5(S)-hydroxyperoxy-6E,8Z,11Z,14Z-icosatetraenoic acid binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with 5(S)-hydroxyperoxy-6E,8Z,11Z,14Z-icosatetraenoic acid, a straight-chain fatty acid with twenty carbon atoms and four double bonds." [GOC:ai]


id: GO:0050649
name: testosterone 6-beta-hydroxylase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: testosterone + donor-H2 + O2 = 6-beta-hydroxytestosterone + H2O." [GOC:ai, PMID:11726664]


id: GO:0050650
name: chondroitin sulfate proteoglycan biosynthetic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of chondroitin sulfate proteoglycan, any glycoprotein whose glycosaminoglycan units are chondroitin sulfate. Chondroitin sulfates are a group of 10-60 kDa glycosaminoglycans, widely distributed in cartilage and other mammalian connective tissues; the repeat units consist of beta-(1,4)-linked D-glucuronyl beta-(1,3)-N-acetyl-D-galactosamine sulfate." [GOC:ai]


id: GO:0050651
name: dermatan sulfate proteoglycan biosynthetic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of dermatan sulfate proteoglycan, any glycoprotein whose glycosaminoglycan units are dermatan sulfate (chondroitin sulfate B). Dermatan sulfate is a glycosaminoglycan with repeats consisting of beta-(1,4)-linked L-iduronyl-beta-(1,3)-N-acetyl-D-galactosamine 4-sulfate units." [GOC:ai]


id: GO:0050652
name: dermatan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process
namespace: biological_process
def:
  "The elongation of dermatan sulfate proteoglycan chains by alternate addition of N-acetylhexosamine and GlcUA residues to the GAG-protein linkage region tetrasaccharide of dermatan sulfate." [GOC:ai, PMID:11788602]


id: GO:0050653
name: chondroitin sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process
namespace: biological_process
def:
  "The elongation of chondroitin sulfate proteoglycan chains by alternate addition of N-acetylhexosamine and GlcUA residues to the GAG-protein linkage region tetrasaccharide of chondroitin sulfate." [GOC:ai, PMID:11788602]


id: GO:0050654
name: chondroitin sulfate proteoglycan metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving chondroitin sulfate proteoglycan, any glycoprotein whose glycosaminoglycan units are chondroitin sulfate. Chondroitin sulfates are a group of 10-60 kDa glycosaminoglycans, widely distributed in cartilage and other mammalian connective tissues; the repeat units consist of beta-(1,4)-linked D-glucuronyl beta-(1,3)-N-acetyl-D-galactosamine sulfate." [GOC:ai]


id: GO:0050655
name: dermatan sulfate proteoglycan metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving dermatan sulfate proteoglycan, any glycoprotein whose glycosaminoglycan units are dermatan sulfate (chondroitin sulfate B). Dermatan sulfate is a glycosaminoglycan with repeats consisting of beta-(1,4)-linked L-iduronyl-beta-(1,3)-N-acetyl-D-galactosamine 4-sulfate units." [GOC:ai]


id: GO:0050656
name: 3'-phosphoadenosine 5'-phosphosulfate binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with 3'-phosphoadenosine 5'-phosphosulfate (PAPS), a naturally occurring mixed anhydride. It is an intermediate in the formation of a variety of sulfo compounds in biological systems." [GOC:ai]


id: GO:0050657
name: nucleic acid transport
namespace: biological_process
def:
  "The directed movement of nucleic acids, single or double-stranded polynucleotides involved in the storage, transmission and transfer of genetic information, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai, ISBN:0198506732]


id: GO:0050658
name: RNA transport
namespace: biological_process
def:
  "The directed movement of RNA, ribonucleic acids, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]


id: GO:0050659
name: N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase activity
namespace: molecular_function
def:
  "Catalysis of the reactions: 3'-phosphoadenylyl sulfate + dermatan = adenosine 3',5'-bisphosphate + dermatan 6'-sulfate and 3'-phosphoadenylyl sulfate + chondroitin = adenosine 3',5'-bisphosphate + chondroitin 6'-sulfate." [EC:2.8.2.33]


id: GO:0050660
name: flavin adenine dinucleotide binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2." [CHEBI:24040, GOC:ai, GOC:imk, ISBN:0198506732]


id: GO:0050661
name: NADP binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP+, or the reduced form, NADPH." [GOC:ai]


id: GO:0050662
name: coenzyme binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with a coenzyme, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed." [ISBN:0198506732]


id: GO:0050663
name: cytokine secretion
namespace: biological_process
def:
  "The regulated release of cytokines from a cell. Cytokines are any of a group of proteins that function to control the survival, growth and differentiation of tissues and cells, and which have autocrine and paracrine activity." [GOC:ai, GOC:bf, ISBN:0198599471]


id: GO:0050664
name: oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor
namespace: molecular_function
def:
  "Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces an oxygen molecule." [EC:1.6.3.-]


id: GO:0050665
name: hydrogen peroxide biosynthetic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of hydrogen peroxide (H2O2), a potentially harmful byproduct of aerobic cellular respiration which can cause damage to DNA." [GOC:ai]


id: GO:0050666
name: regulation of homocysteine metabolic process
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving homocysteine, the amino acid alpha-amino-gamma-mercaptobutanoic acid." [GOC:ai]


id: GO:0050667
name: homocysteine metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving homocysteine, the amino acid alpha-amino-gamma-mercaptobutanoic acid. Homocysteine is an important intermediate in the metabolic reactions of its S-methyl derivative, methionine." [ISBN:0198506732]


id: GO:0050668
name: positive regulation of homocysteine metabolic process
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving homocysteine." [GOC:ai]


id: GO:0050669
name: negative regulation of homocysteine metabolic process
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving homocysteine." [GOC:ai]


id: GO:0050672
name: negative regulation of lymphocyte proliferation
namespace: biological_process
def:
  "Any process that stops, prevents or reduces the rate or extent of lymphocyte proliferation." [GOC:ai]


id: GO:0050673
name: epithelial cell proliferation
namespace: biological_process
def:
  "The multiplication or reproduction of epithelial cells, resulting in the expansion of a cell population. Epithelial cells make up the epithelium, the covering of internal and external surfaces of the body, including the lining of vessels and other small cavities. It consists of cells joined by small amounts of cementing substances." [ISBN:0721662544]


id: GO:0050674
name: urothelial cell proliferation
namespace: biological_process
def:
  "The multiplication or reproduction of urothelial cells, resulting in the expansion of a cell population. Urothelial cells make up a layer of transitional epithelium in the wall of the bladder, ureter, and renal pelvis, external to the lamina propria." [ISBN:0721662544]


id: GO:0050675
name: regulation of urothelial cell proliferation
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of urothelial cell proliferation." [GOC:ai]


id: GO:0050676
name: negative regulation of urothelial cell proliferation
namespace: biological_process
def:
  "Any process that stops, prevents or reduces the rate or extent of urothelial cell proliferation." [GOC:ai]


id: GO:0050677
name: positive regulation of urothelial cell proliferation
namespace: biological_process
def:
  "Any process that activates or increases the rate or extent of urothelial cell proliferation." [GOC:ai]


id: GO:0050678
name: regulation of epithelial cell proliferation
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of epithelial cell proliferation." [GOC:ai]


id: GO:0050679
name: positive regulation of epithelial cell proliferation
namespace: biological_process
def:
  "Any process that activates or increases the rate or extent of epithelial cell proliferation." [GOC:ai]


id: GO:0050680
name: negative regulation of epithelial cell proliferation
namespace: biological_process
def:
  "Any process that stops, prevents or reduces the rate or extent of epithelial cell proliferation." [GOC:ai]


id: GO:0050682
name: AF-2 domain binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with the AF-2 domain of a protein, a highly conserved ligand-dependent transactivation domain which is essential for receptor-mediated transcriptional activation." [PMID:9682036]


id: GO:0050683
name: AF-1 domain binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with the AF-1 domain of a protein, a ligand-independent transactivation domain which is required for the full transcriptional activity of the receptor." [PMID:9682036]


id: GO:0050684
name: regulation of mRNA processing
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of mRNA processing, those processes involved in the conversion of a primary mRNA transcript into a mature mRNA prior to its translation into polypeptide." [GOC:ai]


id: GO:0050685
name: positive regulation of mRNA processing
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of mRNA processing." [GOC:ai]


id: GO:0050686
name: negative regulation of mRNA processing
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of mRNA processing." [GOC:ai]


id: GO:0050687
name: negative regulation of defense response to virus
namespace: biological_process
def:
  "Any process that stops, prevents or reduces the rate or extent of antiviral mechanisms, thereby facilitating viral replication." [GOC:ai]


id: GO:0050688
name: regulation of defense response to virus
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of the antiviral response of a cell or organism." [GOC:ai]


id: GO:0050689
name: negative regulation of defense response to virus by host
namespace: biological_process
def:
  "Any host process that results in the inhibition of antiviral immune response mechanisms, thereby facilitating viral replication. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:ai, GOC:dph, GOC:tb]


id: GO:0050690
name: regulation of defense response to virus by virus
namespace: biological_process
def:
  "Any viral process that modulates the frequency, rate, or extent of the antiviral response of the host cell or organism." [GOC:ai, GOC:dph]


id: GO:0050691
name: regulation of defense response to virus by host
namespace: biological_process
def:
  "Any host process that modulates the frequency, rate, or extent of the antiviral response of a host cell or organism." [GOC:ai, GOC:dph]


id: GO:0050692
name: DBD domain binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with the DBD, DNA binding domain, of a protein. The DNA binding domain of the vitamin D receptor, one of a family of receptors with the DBD, is split into three regions, the P, D and T boxes. Residues that are critical for target sequence selectivity form the P-box. The D-box contains residues that are important for homodimerization of class I nuclear receptors. The T-box is essential for both DNA-binding and transactivation of the VDR; this region may also be important for dimerization with RXR for class II nuclear receptors." [PMID:9682036]


id: GO:0050693
name: LBD domain binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with the LBD, the ligand binding domain found in nuclear receptors. In general, the LBDs consist of three layers comprised of twelve alpha-helices and several beta-strands that are organized around a lipophilic ligand-binding pocket." [PMID:9682036]


id: GO:0050694
name: galactose 3-O-sulfotransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: N-acetyllactosamine + 3'-phosphoadenosine 5'-phosphosulfate = 3-sulfo-N-acetyllactosamine + adenosine 3',5'-bisphosphate. N-acetyllactosamine residues are found in a number of different carbohydrate types. N-acetyllactosamine can also be written as Gal-beta-(1,4)-GlcNAc." [GOC:ai, PMID:11323440, PMID:11356829]


id: GO:0050695
name: benzoylformate decarboxylase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: benzoylformate = benzaldehyde + CO2." [EC:4.1.1.7, MetaCyc:BENZOYLFORMATE-DECARBOXYLASE-RXN]


id: GO:0050696
name: trichloroethylene catabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the breakdown of trichloroethylene, a toxic, colorless, photoreactive, chlorinated hydrocarbon liquid, commonly used as a metal degreaser and solvent." [GOC:ai]


id: GO:0050697
name: 1,1,2-trichloroethene reductive dehalogenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: trichloroethene + 2 H+ + 2 e- = HCl + 1,2-dichloroethene." [MetaCyc:TCEREDCHLOR-RXN, UM-BBD_enzymeID:e0271]


id: GO:0050698
name: proteoglycan sulfotransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + proteoglycan = adenosine 3',5'-bisphosphate + proteoglycan sulfate. A proteoglycan is a glycoprotein whose carbohydrate units are glycosaminoglycans." [EC:2.8.2.-, GOC:ai]


id: GO:0050699
name: WW domain binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with a WW domain of a protein, a small module composed of 40 amino acids and plays a role in mediating protein-protein interactions via proline-rich regions." [PMID:14531730]


id: GO:0050700
name: CARD domain binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with a CARD (N-terminal caspase recruitment) domain, a protein-protein interaction domain that belongs to the death domain-fold superfamily. These protein molecule families are similar in structure with each consisting of six or seven anti-parallel alpha-helices that form highly specific homophilic interactions between signaling partners. CARD exists in the N-terminal prodomains of several caspases and in apoptosis-regulatory proteins and mediates the assembly of CARD-containing proteins that participate in activation or suppression of CARD carrying members of the caspase family." [PMID:12054670]


id: GO:0050701
name: interleukin-1 secretion
namespace: biological_process
def:
  "The regulated release of interleukin-1 from a cell. Interleukin 1 is produced mainly by activated macrophages; it stimulates thymocyte proliferation by inducing interleukin 2 release and it is involved in the inflammatory response." [GOC:ai, ISBN:0198506732]


id: GO:0050704
name: regulation of interleukin-1 secretion
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of the regulated release of interleukin-1 from a cell." [GOC:ai]


id: GO:0050705
name: regulation of interleukin-1 alpha secretion
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of the regulated release of interleukin-1 alpha from a cell." [GOC:ai]


id: GO:0050706
name: regulation of interleukin-1 beta secretion
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of the regulated release of interleukin-1 beta from a cell." [GOC:ai]


id: GO:0050707
name: regulation of cytokine secretion
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of the regulated release of cytokines from a cell." [GOC:ai]


id: GO:0050708
name: regulation of protein secretion
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of the controlled release of a protein from a cell." [GOC:ai]


id: GO:0050709
name: negative regulation of protein secretion
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of the controlled release of a protein from a cell." [GOC:ai]


id: GO:0050710
name: negative regulation of cytokine secretion
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of cytokines from a cell." [GOC:ai]


id: GO:0050711
name: negative regulation of interleukin-1 secretion
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of interleukin-1 from a cell." [GOC:ai]


id: GO:0050712
name: negative regulation of interleukin-1 alpha secretion
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of interleukin-1 alpha from a cell." [GOC:ai]


id: GO:0050713
name: negative regulation of interleukin-1 beta secretion
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of interleukin-1 beta from a cell." [GOC:ai]


id: GO:0050714
name: positive regulation of protein secretion
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of the controlled release of a protein from a cell." [GOC:ai]


id: GO:0050715
name: positive regulation of cytokine secretion
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of the regulated release of cytokines from a cell." [GOC:ai]


id: GO:0050716
name: positive regulation of interleukin-1 secretion
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of the regulated release of interleukin-1 from a cell." [GOC:ai]


id: GO:0050717
name: positive regulation of interleukin-1 alpha secretion
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of the regulated release of interleukin-1 alpha from a cell." [GOC:ai]


id: GO:0050718
name: positive regulation of interleukin-1 beta secretion
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of the regulated release of interleukin-1 beta from a cell." [GOC:ai]


id: GO:0050721
name: regulation of interleukin-1 alpha biosynthetic process
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-1 alpha." [GOC:ai]


id: GO:0050722
name: regulation of interleukin-1 beta biosynthetic process
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-1 beta." [GOC:ai]


id: GO:0050723
name: negative regulation of interleukin-1 alpha biosynthetic process
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-1 alpha." [GOC:ai]


id: GO:0050724
name: negative regulation of interleukin-1 beta biosynthetic process
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-1 beta." [GOC:ai]


id: GO:0050725
name: positive regulation of interleukin-1 beta biosynthetic process
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-1 beta." [GOC:ai]


id: GO:0050726
name: positive regulation of interleukin-1 alpha biosynthetic process
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of interleukin-1 alpha." [GOC:ai]


id: GO:0050727
name: regulation of inflammatory response
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of the inflammatory response, the immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents." [GOC:ai]


id: GO:0050728
name: negative regulation of inflammatory response
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of the inflammatory response." [GOC:ai]


id: GO:0050729
name: positive regulation of inflammatory response
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of the inflammatory response." [GOC:ai]


id: GO:0050730
name: regulation of peptidyl-tyrosine phosphorylation
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of the phosphorylation of peptidyl-tyrosine." [GOC:ai]


id: GO:0050731
name: positive regulation of peptidyl-tyrosine phosphorylation
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of the phosphorylation of peptidyl-tyrosine." [GOC:ai]


id: GO:0050732
name: negative regulation of peptidyl-tyrosine phosphorylation
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of the phosphorylation of peptidyl-tyrosine." [GOC:ai]


id: GO:0050733
name: RS domain binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with an RS domain of a protein; RS domains are usually highly phosphorylated and characterized by the presence of arginine (R)/serine (S) dipeptides. The RS domain promotes protein-protein interactions and directs subcellular localization and, in certain situations, nucleocytoplasmic shuttling of individual SR proteins. They also play a role in splicing." [PMID:11684676, PMID:12215544]


id: GO:0050735
name: N-malonyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the transfer of a malonyl group to a nitrogen atom on the acceptor molecule." [GOC:ai]


id: GO:0050737
name: O-hydroxycinnamoyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the transfer of a hydroxycinnamoyl group to an oxygen atom on the acceptor molecule." [GOC:ai]


id: GO:0050738
name: fructosyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the transfer of a fructosyl group to an acceptor molecule, typically another carbohydrate or a lipid." [GOC:ai]


id: GO:0050739
name: peptide cross-linking via S-[5'-(L-tryptoph-6'-yl)-L-tyrosin-3'-yl]-L-methionin-S-ium
namespace: biological_process
def:
  "The cross-linking of a tyrosine residue to a tryptophan residue and a methionine residue to form S-[5'-(L-tryptoph-6'-yl)-L-tyrosin-3'-yl]-L-methionin-S-ium." [RESID:AA0348]


id: GO:0050743
name: protein-FMN linkage via 1'-(8alpha-FMN)-L-histidine
namespace: biological_process
def:
  "The formation of a protein-FMN linkage via 1'-(8alpha-FMN)-L-histidine." [PMID:8611516, RESID:AA0352]


id: GO:0050745
name: peptide cross-linking via L-cysteinyl-5-imidazolinone glycine
namespace: biological_process
def:
  "The formation of a protein active site cross-link from the alpha-carboxyl carbon of residue N, a cysteine, to the alpha-amino nitrogen of residue N+2, a glycine, coupled with the formation of a double bond to the alpha-amino nitrogen of residue N+1 which loses one hydrogen, and the loss of a molecule of water." [RESID:AA0188]


id: GO:0050746
name: regulation of lipoprotein metabolic process
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving lipoproteins, any conjugated, water-soluble protein in which the nonprotein group consists of a lipid or lipids." [GOC:ai]


id: GO:0050747
name: positive regulation of lipoprotein metabolic process
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving lipoproteins, any conjugated, water-soluble protein in which the nonprotein group consists of a lipid or lipids." [GOC:ai]


id: GO:0050748
name: negative regulation of lipoprotein metabolic process
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving lipoproteins, any conjugated, water-soluble protein in which the nonprotein group consists of a lipid or lipids." [GOC:ai]


id: GO:0050751
name: fractalkine biosynthetic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of fractalkine, a chemokine involved in the control of the key regulatory mechanisms of cell trafficking at sites of inflammation. It exists as a secreted protein and in a membrane-bound form, and exhibits a novel C-X-X-X-C cysteine signature motif. The counterpart of human fractalkine is murine neurotactin; fractalkine is also referred to as CX3C membrane-anchored chemokine or ABCD-3 and has been renamed CX3CL1." [http://www.copewithcytokines.de]


id: GO:0050752
name: regulation of fractalkine biosynthetic process
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of fractalkine, a chemokine involved in the control of the key regulatory mechanisms of cell trafficking at sites of inflammation." [http://www.copewithcytokines.de]


id: GO:0050753
name: negative regulation of fractalkine biosynthetic process
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of fractalkine, a chemokine involved in the control of the key regulatory mechanisms of cell trafficking at sites of inflammation." [http://www.copewithcytokines.de]


id: GO:0050754
name: positive regulation of fractalkine biosynthetic process
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of fractalkine, a chemokine involved in the control of the key regulatory mechanisms of cell trafficking at sites of inflammation." [http://www.copewithcytokines.de]


id: GO:0050755
name: chemokine metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving chemokines, any member of a family of small chemotactic cytokines; their name is derived from their ability to induce directed chemotaxis in nearby responsive cells. All chemokines possess a number of conserved cysteine residues involved in intramolecular disulfide bond formation. Some chemokines are considered pro-inflammatory and can be induced during an immune response to recruit cells of the immune system to a site of infection, while others are considered homeostatic and are involved in controlling the migration of cells during normal processes of tissue maintenance or development. Chemokines are found in all vertebrates, some viruses and some bacteria." [GOC:BHF, GOC:rl, http://en.wikipedia.org/wiki/Chemokine, ISBN:0198506732, PMID:12183377]


id: GO:0050756
name: fractalkine metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving fractalkine, a chemokine involved in the control of the key regulatory mechanisms of cell trafficking at sites of inflammation. It exists as a secreted protein and in a membrane-bound form, and exhibits a novel C-X-X-X-C cysteine signature motif. The counterpart of human fractalkine is murine neurotactin; fractalkine is also referred to as CX3C membrane-anchored chemokine or ABCD-3 and has been renamed CX3CL1." [http://www.copewithcytokines.de]


id: GO:0050757
name: thymidylate synthase biosynthetic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of the enzyme thymidylate synthase, which catalyzes the reaction: 5,10-methylenetetrahydrofolate + dUMP = dihydrofolate + dTMP." [EC:2.1.1.45]


id: GO:0050758
name: regulation of thymidylate synthase biosynthetic process
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of the enzyme thymidylate synthase." [GOC:ai]


id: GO:0050759
name: positive regulation of thymidylate synthase biosynthetic process
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of the enzyme thymidylate synthase." [GOC:ai]


id: GO:0050760
name: negative regulation of thymidylate synthase biosynthetic process
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of the enzyme thymidylate synthase." [GOC:ai]


id: GO:0050761
name: depsipeptide metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving depsipeptides, a linear or cyclic compound composed of both amino acids and hydroxy acids in peptide and ester bonds respectively." [GOC:go_curators]


id: GO:0050762
name: depsipeptide catabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the breakdown of depsipeptides, a linear or cyclic compound composed of both amino acids and hydroxy acids in peptide and ester bonds respectively." [GOC:go_curators]


id: GO:0050763
name: depsipeptide biosynthetic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of depsipeptides, a linear or cyclic compound composed of both amino acids and hydroxy acids in peptide and ester bonds respectively." [GOC:go_curators]


id: GO:0050764
name: regulation of phagocytosis
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of phagocytosis, the process in which phagocytes engulf external particulate material." [GOC:ai]


id: GO:0050765
name: negative regulation of phagocytosis
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of phagocytosis." [GOC:ai]


id: GO:0050767
name: regulation of neurogenesis
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of neurogenesis, the origin and formation of neurons." [GOC:ai]


id: GO:0050768
name: negative regulation of neurogenesis
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of neurogenesis, the origin and formation of neurons." [GOC:ai]


id: GO:0050769
name: positive regulation of neurogenesis
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of neurogenesis, the origin and formation of neurons." [GOC:ai]


id: GO:0050770
name: regulation of axonogenesis
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of axonogenesis, the generation of an axon, the long process of a neuron." [GOC:ai]


id: GO:0050771
name: negative regulation of axonogenesis
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of axonogenesis." [GOC:ai]


id: GO:0050774
name: negative regulation of dendrite morphogenesis
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of dendrite morphogenesis." [GOC:ai]


id: GO:0050775
name: positive regulation of dendrite morphogenesis
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of dendrite morphogenesis." [GOC:ai]


id: GO:0050776
name: regulation of immune response
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus." [GOC:ai]


id: GO:0050777
name: negative regulation of immune response
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus." [GOC:ai]


id: GO:0050778
name: positive regulation of immune response
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of the immune response, the immunological reaction of an organism to an immunogenic stimulus." [GOC:ai]


id: GO:0050779
name: RNA destabilization
namespace: biological_process
def:
  "Any process that decreases the stability of an RNA molecule, making it more vulnerable to degradative processes." [GOC:ai]


id: GO:0050781
name: ortho-trichlorophenol reductive dehalogenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 2,4,6-trichlorophenol + 2 H+ + 2 e- = 2,4-dichlorophenol + HCl." [GOC:ai, PMID:12697029]


id: GO:0050782
name: galactose uniporter activity
namespace: molecular_function
def:
  "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: galactose (out) = galactose(in)." [GOC:ai, TC:2.A.1.1.6]


id: GO:0050783
name: cocaine metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving cocaine, an alkaloid obtained from the dried leaves of the shrub Erythroxylon coca. It is a cerebral stimulant and narcotic." [ISBN:0198506732]


id: GO:0050784
name: cocaine catabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the breakdown of cocaine, an alkaloid obtained from the dried leaves of the shrub Erythroxylon coca. It is a cerebral stimulant and narcotic." [ISBN:0198506732]


id: GO:0050785
name: advanced glycation end-product receptor activity
namespace: molecular_function
def:
  "Combining with advanced glycation end-products and transmitting the signal to initiate a change in cell activity. Advanced glycation end-products (AGEs) form from a series of chemical reactions after an initial glycation event (a non-enzymatic reaction between reducing sugars and free amino groups of proteins)." [GOC:signaling, PMID:12453678, PMID:12707408, PMID:7592757, PMID:9224812, Wikipedia:RAGE_(receptor)]


id: GO:0050786
name: RAGE receptor binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with the RAGE receptor, the receptor for advanced glycation end-products." [GOC:ai]


id: GO:0050787
name: detoxification of mercury ion
namespace: biological_process
def:
  "Any process that reduce or remove the toxicity of mercuric ion. These include transport of mercury away from sensitive areas and to compartments or complexes whose purpose is sequestration of mercury ion and/or reduction of mercury ion (Hg[II]) to metallic mercury (Hg[0])." [PMID:10774920]


id: GO:0050788
name: sequestering of mercury
namespace: biological_process
def:
  "The process of binding or confining toxic mercury ions or atoms such that they are separated from sensitive components of a biological system." [PMID:10774920]


id: GO:0050789
name: regulation of biological process
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule." [GOC:ai, GOC:go_curators]


id: GO:0050792
name: regulation of viral process
namespace: biological_process
def:
  "Any process that modulates the rate or extent of the viral life cycle, the set of processes by which a virus reproduces and spreads among hosts." [GOC:go_curators, GOC:tb]


id: GO:0050793
name: regulation of developmental process
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of development, the biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:go_curators]


id: GO:0050794
name: regulation of cellular process
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:go_curators]


id: GO:0050795
name: regulation of behavior
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of behavior, the internally coordinated responses (actions or inactions) of whole living organisms (individuals or groups) to internal or external stimuli." [GOC:go_curators, GOC:pr]


id: GO:0050796
name: regulation of insulin secretion
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of the regulated release of insulin." [GOC:ai]


id: GO:0050797
name: thymidylate synthase (FAD) activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 5,10-methylenetetrahydrofolate + dUMP + NADPH + H+ = dTMP + tetrahydrofolate + NADP+." [EC:2.1.1.148]


id: GO:0050798
name: activated T cell proliferation
namespace: biological_process
def:
  "The expansion of a T cell population following activation by an antigenic stimulus." [GOC:add, GOC:dph]


id: GO:0050799
name: cocaine biosynthetic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of cocaine, an alkaloid obtained from the dried leaves of the shrub Erythroxylon coca. It is a cerebral stimulant and narcotic." [GOC:ai]


id: GO:0050800
namespace: molecular_function
name:
  obsolete hydrolase activity, acting on acid anhydrides, acting on GTP, involved in cellular and subcellular movement

def:
  "OBSOLETE. Catalysis of the hydrolysis of GTP to directly drive the cellular or subcellular transport of a substance." [EC:3.6.5.-, GOC:ai]


id: GO:0050801
name: ion homeostasis
namespace: biological_process
def:
  "Any process involved in the maintenance of an internal steady state of ions within an organism or cell." [GOC:ai]


id: GO:0050803
name: regulation of synapse structure or activity
namespace: biological_process
def:
  "Any process that modulates the physical form or the activity of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell)." [GOC:ai]


id: GO:0050804
name: modulation of synaptic transmission
namespace: biological_process
def:
  "Any process that modulates the frequency or rate of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse." [GOC:ai]


id: GO:0050805
name: negative regulation of synaptic transmission
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse." [GOC:ai]


id: GO:0050806
name: positive regulation of synaptic transmission
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse." [GOC:ai]


id: GO:0050807
name: regulation of synapse organization
namespace: biological_process
def:
  "Any process that modulates the physical form of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell)." [GOC:ai, GOC:dph, GOC:tb]


id: GO:0050808
name: synapse organization
namespace: biological_process
def:
  "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a synapse, the junction between a neuron and a target (neuron, muscle, or secretory cell)." [GOC:ai, GOC:pr]


id: GO:0050809
name: diazepam binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with diazepam, one of the most widely used benzodiazepine drugs. It is used as an anti-anxiety-hypnotic agent and has the proprietary name Valium." [ISBN:0198506732]


id: GO:0050810
name: regulation of steroid biosynthetic process
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus." [GOC:ai]


id: GO:0050811
name: GABA receptor binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with the gamma-aminobutyric acid (GABA, 4-aminobutyrate) receptor." [GOC:ai]


id: GO:0050812
name: regulation of acyl-CoA biosynthetic process
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of acyl-CoA." [GOC:ai]


id: GO:0050813
name: epothilone metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving epothilone, a drug obtained from the myxobacteria Sporangium cellulosum that interferes with cell division. Some epothilones are being studied as treatments for cancer." [http://www.onelook.com/, ISBN:0198506732]


id: GO:0050814
name: epothilone biosynthetic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of epothilone, a drug obtained from the myxobacteria Sporangium cellulosum that interferes with cell division. Some epothilones are being studied as treatments for cancer." [GOC:ai]


id: GO:0050815
name: phosphoserine binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with a phosphorylated serine residue within a protein." [GOC:ai]


id: GO:0050816
name: phosphothreonine binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with a phosphorylated threonine residue within a protein." [GOC:ai]


id: GO:0050817
name: coagulation
namespace: biological_process
def:
  "The process in which a fluid solution, or part of it, changes into a solid or semisolid mass." [ISBN:0198506732]


id: GO:0050818
name: regulation of coagulation
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of coagulation, the process in which a fluid solution, or part of it, changes into a solid or semisolid mass." [GOC:ai]


id: GO:0050819
name: negative regulation of coagulation
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of coagulation." [GOC:ai]


id: GO:0050821
name: protein stabilization
namespace: biological_process
def:
  "Any process involved in maintaining the structure and integrity of a protein and preventing it from degradation or aggregation." [GOC:ai]


id: GO:0050822
name: peptide stabilization
namespace: biological_process
def:
  "Any process involved in maintaining the structure and integrity of a peptide and preventing it from being degraded." [GOC:ai]


id: GO:0050823
name: peptide antigen stabilization
namespace: biological_process
def:
  "Any process involved in maintaining the structure and integrity of a peptide antigen and preventing it from being degraded." [GOC:ai]


id: GO:0050825
name: ice binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with ice, water reduced to the solid state by cold temperature. It is a white or transparent colorless substance, crystalline, brittle, and viscoidal." [GOC:curators]


id: GO:0050826
name: response to freezing
namespace: biological_process
def:
  "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a freezing stimulus, temperatures below 0 degrees Celsius." [GOC:jl]


id: GO:0050827
name: toxin receptor binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with a toxin receptor, a receptor for substances that cause injury to living organisms." [GOC:ai]


id: GO:0050828
name: regulation of liquid surface tension
namespace: biological_process
def:
  "Any process that modulates the surface tension of a liquid. Surface tension is the property that makes a liquid behave as if it had an elastic skin on its surface at the interface with a gas or an immiscible liquid." [ISBN:0198506732]


id: GO:0050829
name: defense response to Gram-negative bacterium
namespace: biological_process
def:
  "Reactions triggered in response to the presence of a Gram-negative bacterium that act to protect the cell or organism." [GOC:ai]


id: GO:0050830
name: defense response to Gram-positive bacterium
namespace: biological_process
def:
  "Reactions triggered in response to the presence of a Gram-positive bacterium that act to protect the cell or organism." [GOC:ai]


id: GO:0050831
name: male-specific defense response to bacterium
namespace: biological_process
def:
  "A set of reactions, specific to males, that are triggered in response to the presence of a bacterium that act to protect the cell or organism." [GOC:ai]


id: GO:0050832
name: defense response to fungus
namespace: biological_process
def:
  "Reactions triggered in response to the presence of a fungus that act to protect the cell or organism." [GOC:ai]


id: GO:0050833
name: pyruvate transmembrane transporter activity
namespace: molecular_function
def:
  "Enables the transfer of pyruvate, 2-oxopropanoate, from one side of the membrane to the other." [GOC:ai]


id: GO:0050834
name: molybdenum incorporation via L-cysteinyl copper sulfido molybdopterin cytosine dinucleotide
namespace: biological_process
def:
  "The incorporation of molybdenum into a protein by L-cysteinyl copper sulfido molybdopterin cytosine dinucleotide." [RESID:AA0355]


id: GO:0050835
namespace: biological_process
name:
  iron incorporation into iron-sulfur cluster via tris-L-cysteinyl S-adenosylmethion-N,O-diyl tetrairon tetrasulfide

def:
  "The incorporation of iron into a 4Fe-4S iron-sulfur cluster via tris-L-cysteinyl S-adenosylmethion-N,O-diyl tetrairon tetrasulfide." [RESID:AA0356]


id: GO:0050836
name: iron incorporation into iron-sulfur cluster via tris-L-cysteinyl L-arginyl diiron disulfide
namespace: biological_process
def:
  "The incorporation of iron into a 4Fe-4S iron-sulfur cluster via tris-L-cysteinyl L-arginyl diiron disulfide." [RESID:AA0357]


id: GO:0050837
name: peptide cross-linking via L-cysteinyl-L-selenocysteine
namespace: biological_process
def:
  "The formation of a selenide-sulfide bond to form the cystine-like L-cysteinyl-L-selenocysteine, as in vertebrate selenopeptide P." [RESID:AA0358]


id: GO:0050838
name: peptidyl-5-hydroxy-L-lysine trimethylation
namespace: biological_process
def:
  "The methylation of 5-hydroxy-L-lysine to form peptidyl-N6,N6,N6-trimethyl-5-hydroxy-L-lysine." [RESID:AA0359]


id: GO:0050841
name: peptidyl-N6,N6,N6-trimethyl-lysine hydroxylation to peptidyl-N6,N6,N6-trimethyl-5-hydroxy-L-lysine
namespace: biological_process
def:
  "The hydroxylation of peptidyl-N6,N6,N6-trimethyl-L-lysine to form peptidyl-N6,N6,N6-trimethyl-5-hydroxy-L-lysine." [RESID:AA0359]


id: GO:0050842
name: copper incorporation via L-cysteinyl copper sulfido molybdopterin cytosine dinucleotide
namespace: biological_process
def:
  "The incorporation of copper into a protein by L-cysteinyl copper sulfido molybdopterin cytosine dinucleotide." [RESID:AA0355]


id: GO:0050843
name: S-adenosylmethionine catabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the breakdown of S-adenosylmethionine, S-(5'-adenosyl)-L-methionine, an important intermediate in one-carbon metabolism." [GOC:ai]


id: GO:0050845
name: teichuronic acid biosynthetic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of teichuronic acid, a polymer containing chains of uronic acids and N-acetylglucosamine found in the cell wall, membrane or capsule of Gram-positive bacteria." [ISBN:0815108893]


id: GO:0050846
name: teichuronic acid metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving teichuronic acid, a polymer containing chains of uronic acids and N-acetylglucosamine found in the cell wall, membrane or capsule of Gram-positive bacteria." [ISBN:0815108893]


id: GO:0050847
name: progesterone receptor signaling pathway
namespace: biological_process
def:
  "Any series of molecular signals generated as a consequence of a progesterone binding to its receptor." [GOC:ai, GOC:mah, PMID:14744870]


id: GO:0050848
name: regulation of calcium-mediated signaling
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of calcium-mediated signaling, the process in which a cell uses calcium ions to convert an extracellular signal into a response." [GOC:ai]


id: GO:0050849
name: negative regulation of calcium-mediated signaling
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of calcium-mediated signaling." [GOC:ai, PMID:11696592]


id: GO:0050850
name: positive regulation of calcium-mediated signaling
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of calcium-mediated signaling." [GOC:ai]


id: GO:0050851
name: antigen receptor-mediated signaling pathway
namespace: biological_process
def:
  "A series of molecular signals initiated by the cross-linking of an antigen receptor on a B or T cell." [GOC:add]


id: GO:0050852
name: T cell receptor signaling pathway
namespace: biological_process
def:
  "A series of molecular signals initiated by the cross-linking of an antigen receptor on a T cell." [GOC:add]


id: GO:0050853
name: B cell receptor signaling pathway
namespace: biological_process
def:
  "A series of molecular signals initiated by the cross-linking of an antigen receptor on a B cell." [GOC:add]


id: GO:0050854
name: regulation of antigen receptor-mediated signaling pathway
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a B- or T cell." [GOC:ai]


id: GO:0050855
name: regulation of B cell receptor signaling pathway
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a B cell." [GOC:ai]


id: GO:0050856
name: regulation of T cell receptor signaling pathway
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a T cell." [GOC:ai]


id: GO:0050857
name: positive regulation of antigen receptor-mediated signaling pathway
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a B- or T cell." [GOC:ai]


id: GO:0050858
name: negative regulation of antigen receptor-mediated signaling pathway
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a B- or T cell." [GOC:ai]


id: GO:0050859
name: negative regulation of B cell receptor signaling pathway
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a B cell." [GOC:ai]


id: GO:0050860
name: negative regulation of T cell receptor signaling pathway
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a T cell." [GOC:ai]


id: GO:0050861
name: positive regulation of B cell receptor signaling pathway
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a B cell." [GOC:ai]


id: GO:0050862
name: positive regulation of T cell receptor signaling pathway
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of signaling pathways initiated by the cross-linking of an antigen receptor on a T cell." [GOC:ai]


id: GO:0050865
name: regulation of cell activation
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of cell activation, the change in the morphology or behavior of a cell resulting from exposure to an activating factor such as a cellular or soluble ligand." [GOC:ai]


id: GO:0050866
name: negative regulation of cell activation
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of cell activation." [GOC:ai]


id: GO:0050868
name: negative regulation of T cell activation
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of T cell activation." [GOC:ai]


id: GO:0050869
name: negative regulation of B cell activation
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of B cell activation." [GOC:ai]


id: GO:0050870
name: positive regulation of T cell activation
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of T cell activation." [GOC:ai]


id: GO:0050871
name: positive regulation of B cell activation
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of B cell activation." [GOC:ai]


id: GO:0050872
name: white fat cell differentiation
namespace: biological_process
def:
  "The process in which a relatively unspecialized cell acquires specialized features of a white adipocyte, an animal connective tissue cell involved in energy storage. White adipocytes have cytoplasmic lipids arranged in a unique vacuole." [PMID:12508945]


id: GO:0050873
name: brown fat cell differentiation
namespace: biological_process
def:
  "The process in which a relatively unspecialized cell acquires specialized features of a brown adipocyte, an animal connective tissue cell involved in adaptive thermogenesis. Brown adipocytes contain multiple small droplets of triglycerides and a high number of mitochondria." [PMID:12588810]


id: GO:0050877
name: neurological system process
namespace: biological_process
def:
  "A organ system process carried out by any of the organs or tissues of neurological system." [GOC:ai, GOC:mtg_cardio]


id: GO:0050879
name: multicellular organismal movement
namespace: biological_process
def:
  "Any physiological process involved in changing the position of a multicellular organism or an anatomical part of a multicellular organism." [GOC:dph, GOC:mtg_muscle, GOC:tb]


id: GO:0050881
name: musculoskeletal movement
namespace: biological_process
def:
  "The movement of an organism or part of an organism using mechanoreceptors, the nervous system, striated muscle and/or the skeletal system." [GOC:dph]


id: GO:0050882
name: voluntary musculoskeletal movement
namespace: biological_process
def:
  "The movement of an organism or part of an organism using mechanoreceptors, the nervous system, striated muscle and/or the skeletal system that can be controlled at will." [GOC:dph]


id: GO:0050883
name: musculoskeletal movement, spinal reflex action
namespace: biological_process
def:
  "Involuntary movement caused by the application of a stimulus to an organism and a subsequent movement. The signal processing of this movement takes place in the spinal cord." [GOC:dph]


id: GO:0050884
name: neuromuscular process controlling posture
namespace: biological_process
def:
  "Any process in which an organism voluntarily modulates its posture, the alignment of its anatomical parts." [GOC:dph, GOC:tb]


id: GO:0050885
name: neuromuscular process controlling balance
namespace: biological_process
def:
  "Any process that an organism uses to control its balance, the orientation of the organism (or the head of the organism) in relation to the source of gravity. In humans and animals, balance is perceived through visual cues, the labyrinth system of the inner ears and information from skin pressure receptors and muscle and joint receptors." [GOC:ai, GOC:dph, http://www.onelook.com/]


id: GO:0050886
name: endocrine process
namespace: biological_process
def:
  "The process that involves the secretion of or response to endocrine hormones. An endocrine hormone is a hormone released into the circulatory system." [ISBN:0721662544]


id: GO:0050887
name: determination of sensory modality
namespace: biological_process
def:
  "The determination of the type or quality of a sensation. Sensory modalities include touch, thermal sensation, visual sensation, auditory sensation and pain." [ISBN:0721619908]


id: GO:0050888
name: determination of stimulus location
namespace: biological_process
def:
  "The determination of where on the body surface, within the body or in the environment a stimulus originates." [ISBN:0721619908]


id: GO:0050890
name: cognition
namespace: biological_process
def:
  "The operation of the mind by which an organism becomes aware of objects of thought or perception; it includes the mental activities associated with thinking, learning, and memory." [http://www.onelook.com/, ISBN:0721619908]


id: GO:0050891
name: multicellular organismal water homeostasis
namespace: biological_process
def:
  "Any process involved in the maintenance of an internal steady state of water within a tissue, organ, or a multicellular organism." [GOC:dph, GOC:tb]


id: GO:0050893
name: sensory processing
namespace: biological_process
def:
  "Any neural process required for an organism to sense and interpret the dimensions of a sensory experience: modality, location, intensity and affect." [GOC:dph, ISBN:0721662544]


id: GO:0050894
name: determination of affect
namespace: biological_process
def:
  "Any process in which an emotional response is associated with a particular sensory stimulation." [GOC:ai, GOC:dph, ISBN:0721662544]


id: GO:0050896
name: response to stimulus
namespace: biological_process
def:
  "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus and ends with a change in state or activity or the cell or organism." [GOC:ai, GOC:bf]


id: GO:0050898
name: nitrile metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving nitriles, an organic compound containing trivalent nitrogen attached to one carbon atom. The nitriles are named with reference to the acids produced by their decomposition; for example, hydrocyanic acid is formic nitrile, and methyl cyanide is acetic nitrile." [CHEBI:18379, GOC:curators, ISBN:0721662544]


id: GO:0050899
name: nitrile catabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the breakdown of a nitrile, an organic compound containing trivalent nitrogen attached to one carbon atom." [ISBN:0721662544]


id: GO:0050900
name: leukocyte migration
namespace: biological_process
def:
  "The movement of a leukocyte within or between different tissues and organs of the body." [GOC:add, ISBN:0781735149, PMID:14680625, PMID:14708592, PMID:7507411, PMID:8600538]


id: GO:0050901
name: leukocyte tethering or rolling
namespace: biological_process
def:
  "Transient adhesive interactions between leukocytes and endothelial cells lining blood vessels. Carbohydrates on circulating leukocytes bind selectins on the vessel wall causing the leukocytes to slow down and roll along the inner surface of the vessel wall. During this rolling motion, transitory bonds are formed and broken between selectins and their ligands. Typically the first step in cellular extravasation (the movement of leukocytes out of the circulatory system, towards the site of tissue damage or infection)." [GOC:bf, ISBN:0781735149, PMID:14680625, PMID:14708592, PMID:7507411, PMID:8600538, Wikipedia:Leukocyte_extravasation]


id: GO:0050902
name: leukocyte adhesive activation
namespace: biological_process
def:
  "The activation of loosely bound or rolling leukocytes by signals displayed on blood vessel endothelial cells, which is typically the second step in cellular extravasation." [ISBN:0781735149, PMID:14680625, PMID:14708592, PMID:7507411, PMID:8600538]


id: GO:0050903
name: leukocyte activation-dependent arrest
namespace: biological_process
def:
  "The formation of an integrin-dependent strong adhesive bond between leukocytes and blood vessel endothelial cells which is dependent on prior activation of the leukocyte and leads to the firm attachment of the leukocyte to the endothelial surface, typically the third step in cellular extravasation." [ISBN:0781735149, PMID:14680625, PMID:14708592, PMID:7507411, PMID:8600538]


id: GO:0050904
name: diapedesis
namespace: biological_process
def:
  "The passage of a leukocyte between the tight junctions of endothelial cells lining blood vessels, typically the fourth and final step of cellular extravasation." [ISBN:078173514, PMID:14680625, PMID:14708592, PMID:7507411, PMID:8600538]


id: GO:0050905
name: neuromuscular process
namespace: biological_process
def:
  "Any process pertaining to the functions of the nervous and muscular systems of an organism." [GOC:ai]


id: GO:0050906
name: detection of stimulus involved in sensory perception
namespace: biological_process
def:
  "The series of events involved in sensory perception in which a sensory stimulus is received and converted into a molecular signal." [GOC:ai, GOC:dos, GOC:dph]


id: GO:0050907
name: detection of chemical stimulus involved in sensory perception
namespace: biological_process
def:
  "The series of events in which a chemical stimulus is received and converted into a molecular signal as part of sensory perception." [GOC:ai, GOC:dos]


id: GO:0050908
name: detection of light stimulus involved in visual perception
namespace: biological_process
def:
  "The series of events involved in visual perception in which a light stimulus is received and converted into a molecular signal." [GOC:ai, GOC:dos]


id: GO:0050909
name: sensory perception of taste
namespace: biological_process
def:
  "The series of events required for an organism to receive a gustatory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Gustation involves the direct detection of chemical composition, usually through contact with chemoreceptor cells. This is a neurological process." [GOC:ai, http://www.onelook.com/]


id: GO:0050910
name: detection of mechanical stimulus involved in sensory perception of sound
namespace: biological_process
def:
  "The series of events involved in the perception of sound vibration in which the vibration is received and converted into a molecular signal." [GOC:ai]


id: GO:0050911
name: detection of chemical stimulus involved in sensory perception of smell
namespace: biological_process
def:
  "The series of events involved in the perception of smell in which an olfactory chemical stimulus is received and converted into a molecular signal." [GOC:ai]


id: GO:0050912
name: detection of chemical stimulus involved in sensory perception of taste
namespace: biological_process
def:
  "The series of events involved in the perception of taste in which a gustatory chemical stimulus is received and converted into a molecular signal." [GOC:ai]


id: GO:0050913
name: sensory perception of bitter taste
namespace: biological_process
def:
  "The series of events required to receive a bitter taste stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process." [GOC:ai]


id: GO:0050914
name: sensory perception of salty taste
namespace: biological_process
def:
  "The series of events required to receive a salty taste stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process." [GOC:ai]


id: GO:0050915
name: sensory perception of sour taste
namespace: biological_process
def:
  "The series of events required to receive a sour taste stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process." [GOC:ai]


id: GO:0050916
name: sensory perception of sweet taste
namespace: biological_process
def:
  "The series of events required to receive a sweet taste stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process." [GOC:ai]


id: GO:0050917
name: sensory perception of umami taste
namespace: biological_process
def:
  "The series of events required to receive an umami taste stimulus, convert it to a molecular signal, and recognize and characterize the signal. Umami taste is the savory taste of meats and other foods that are rich in glutamates. This is a neurological process." [GOC:ai]


id: GO:0050918
name: positive chemotaxis
namespace: biological_process
def:
  "The directed movement of a motile cell or organism towards a higher concentration of a chemical." [GOC:ai, GOC:bf, GOC:isa_complete]


id: GO:0050919
name: negative chemotaxis
namespace: biological_process
def:
  "The directed movement of a motile cell or organism towards a lower concentration of a chemical." [GOC:ai, GOC:bf, GOC:isa_complete]


id: GO:0050920
name: regulation of chemotaxis
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of the directed movement of a motile cell or organism in response to a specific chemical concentration gradient." [GOC:ai]


id: GO:0050921
name: positive regulation of chemotaxis
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of the directed movement of a motile cell or organism in response to a specific chemical concentration gradient." [GOC:ai]


id: GO:0050922
name: negative regulation of chemotaxis
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of a motile cell or organism in response to a specific chemical concentration gradient." [GOC:ai]


id: GO:0050923
name: regulation of negative chemotaxis
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of the directed movement of a motile cell or organism towards a lower concentration in a concentration gradient of a specific chemical." [GOC:ai]


id: GO:0050924
name: positive regulation of negative chemotaxis
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of the directed movement of a motile cell or organism towards a lower concentration in a concentration gradient of a specific chemical." [GOC:ai]


id: GO:0050925
name: negative regulation of negative chemotaxis
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of a motile cell or organism towards a lower concentration in a concentration gradient of a specific chemical." [GOC:ai]


id: GO:0050926
name: regulation of positive chemotaxis
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of the directed movement of a motile cell or organism towards a higher concentration in a concentration gradient of a specific chemical." [GOC:ai]


id: GO:0050927
name: positive regulation of positive chemotaxis
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of the directed movement of a motile cell or organism towards a higher concentration in a concentration gradient of a specific chemical." [GOC:ai]


id: GO:0050928
name: negative regulation of positive chemotaxis
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of a motile cell or organism towards a higher concentration in a concentration gradient of a specific chemical." [GOC:ai]


id: GO:0050929
name: induction of negative chemotaxis
namespace: biological_process
def:
  "Any process that initiates the directed movement of a motile cell or organism towards a lower concentration in a concentration gradient of a specific chemical." [GOC:ai]


id: GO:0050930
name: induction of positive chemotaxis
namespace: biological_process
def:
  "Any process that initiates the directed movement of a motile cell or organism towards a higher concentration in a concentration gradient of a specific chemical." [GOC:ai]


id: GO:0050931
name: pigment cell differentiation
namespace: biological_process
def:
  "The process in which a relatively unspecialized cell acquires the specialized features of a pigmented cell, such as a melanocyte." [GOC:dgh]


id: GO:0050932
name: regulation of pigment cell differentiation
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of pigmented cell differentiation." [GOC:ai]


id: GO:0050933
name: early stripe melanocyte differentiation
namespace: biological_process
def:
  "The process in which a relatively unspecialized cell acquires the specialized features of an early stripe melanocyte (ESM). In zebrafish, ESMs develop during the first phase (2-3 weeks of development) of the larva to adult transition (2-4 weeks of development)." [PMID:11858836]


id: GO:0050934
name: late stripe melanocyte differentiation
namespace: biological_process
def:
  "The process in which a relatively unspecialized cell acquires the specialized features of a late stripe melanocyte (LSM). In zebrafish, LSMs develop during the second phase (3-4 weeks of development) of the larva-to-adult transition (2-4 weeks of development)." [PMID:11858836]


id: GO:0050935
name: iridophore differentiation
namespace: biological_process
def:
  "The process in which a relatively unspecialized cell acquires the specialized features of an iridophore. Iridophores are pigment cells derived from the neural crest. They contain guanidine or other purine crystals deposited in stacks called reflecting platets or iridisomes. This gives them a silver, gold, or iridescent appearance." [GOC:jid, GOC:mh, PMID:11858836]


id: GO:0050936
name: xanthophore differentiation
namespace: biological_process
def:
  "The process in which a relatively unspecialized cell acquires the specialized features of a xanthophore cell. Xanthophores are pigment cells derived from the neural crest. They contain pteridine and/or carotenoid pigments in structures called pterinosomes or xanthosomes. This makes them yellow to orange in appearance." [GOC:jid, GOC:mh, PMID:11858836]


id: GO:0050939
name: regulation of early stripe melanocyte differentiation
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of early stripe melanocyte differentiation." [GOC:ai]


id: GO:0050940
name: regulation of late stripe melanocyte differentiation
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of late stripe melanocyte differentiation." [GOC:ai]


id: GO:0050941
name: negative regulation of pigment cell differentiation
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of pigment cell differentiation." [GOC:ai]


id: GO:0050942
name: positive regulation of pigment cell differentiation
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of pigment cell differentiation." [GOC:ai]


id: GO:0050943
name: negative regulation of iridophore differentiation
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of iridophore differentiation." [GOC:ai]


id: GO:0050944
name: negative regulation of xanthophore differentiation
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of xanthophore differentiation." [GOC:ai]


id: GO:0050945
name: positive regulation of iridophore differentiation
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of iridophore differentiation." [GOC:ai]


id: GO:0050946
name: positive regulation of xanthophore differentiation
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of xanthophore differentiation." [GOC:ai]


id: GO:0050947
name: negative regulation of early stripe melanocyte differentiation
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of early stripe melanocyte differentiation." [GOC:ai]


id: GO:0050948
name: positive regulation of early stripe melanocyte differentiation
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of early stripe melanocyte differentiation." [GOC:ai]


id: GO:0050949
name: negative regulation of late stripe melanocyte differentiation
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of late stripe melanocyte differentiation." [GOC:ai]


id: GO:0050950
name: positive regulation of late stripe melanocyte differentiation
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of late stripe melanocyte differentiation." [GOC:ai]


id: GO:0050951
name: sensory perception of temperature stimulus
namespace: biological_process
def:
  "The series of events required for an organism to receive a sensory temperature stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process." [GOC:ai]


id: GO:0050952
name: sensory perception of electrical stimulus
namespace: biological_process
def:
  "The series of events required for an organism to receive a sensory electrical stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process." [GOC:ai]


id: GO:0050953
name: sensory perception of light stimulus
namespace: biological_process
def:
  "The series of events required for an organism to receive a sensory light stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process." [GOC:ai]


id: GO:0050954
name: sensory perception of mechanical stimulus
namespace: biological_process
def:
  "The series of events required for an organism to receive a sensory mechanical stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process." [GOC:ai]


id: GO:0050955
name: thermoception
namespace: biological_process
def:
  "The series of events required for an organism to receive a temperature stimulus, convert it to a molecular signal, and recognize and characterize the signal. Thermoception in larger animals is mainly done in the skin; mammals have at least two types of sensor, for detecting heat (temperatures above body temperature) and cold (temperatures below body temperature)." [GOC:ai, Wikipedia:Thermoception]


id: GO:0050956
name: electroception
namespace: biological_process
def:
  "The series of events required for an organism to receive an electrical stimulus, convert it to a molecular signal, and recognize and characterize the signal. Many fish possess an electroception sense; for example, the electric eel uses low voltage pulses of electricity for navigation and prey location." [GOC:ai, PMID:10210663, Wikipedia:Electroreception]


id: GO:0050957
name: equilibrioception
namespace: biological_process
def:
  "The series of events required for an organism to receive an orientational stimulus, convert it to a molecular signal, and recognize and characterize the signal. Equilibrioception refers to a combination of processes by which an organism can perceive its orientation with respect to gravity. In animals, stimuli come from labyrinth system of the inner ears, monitoring the direction of motion; visual stimuli, with information on orientation and motion; pressure receptors, which tell the organism which body surfaces are in contact with the ground; and proprioceptive cues, which report which parts of the body are in motion." [http://www.medterms.com, http://www.onelook.com/]


id: GO:0050958
name: magnetoreception
namespace: biological_process
def:
  "The series of events required for an organism to receive a stimulus relating to a magnetic field, convert it to a molecular signal, and recognize and characterize the signal. Stimuli may be chemical, mechanical or electrical and interpreting these stimuli allows an organism to determine the orientation of a magnetic field. Magnetoreception also involves the perception of light; birds cannot orient without the presence of short wavelength (blue/green) light." [GOC:ai, PMID:15886990, Wikipedia:Magnetoception]


id: GO:0050959
name: echolocation
namespace: biological_process
def:
  "Echolocation is the method used by some animals (e.g. bats, dolphins and some whales) to determine the location of something by measuring the time it takes for an echo to return from it. These animals emit sound waves and listen for the echo, calculating the distance to the object from the time lapse between sound emission and the echo returning." [http://www.onelook.com/, PMID:16005275, Wikipedia:Animal_echolocation]


id: GO:0050960
name: detection of temperature stimulus involved in thermoception
namespace: biological_process
def:
  "The series of events in which a temperature stimulus is received and converted into a molecular signal as part of thermoception." [GOC:ai, GOC:dos]


id: GO:0050961
name: detection of temperature stimulus involved in sensory perception
namespace: biological_process
def:
  "The series of events in which a temperature stimulus is received and converted into a molecular signal as part of sensory perception." [GOC:ai, GOC:dos]


id: GO:0050962
name: detection of light stimulus involved in sensory perception
namespace: biological_process
def:
  "The series of events in which a light stimulus is received by a cell and converted into a molecular signal as part of the sensory perception of light." [GOC:ai, GOC:dos]


id: GO:0050963
name: detection of electrical stimulus involved in sensory perception
namespace: biological_process
def:
  "The series of events in which an electrical stimulus is received by a cell and converted into a molecular signal as part of sensory perception." [GOC:ai, GOC:dos]


id: GO:0050964
name: detection of electrical stimulus involved in electroception
namespace: biological_process
def:
  "The series of events that contribute to electroception in which an electrical stimulus is received and converted into a molecular signal." [GOC:ai, GOC:dos]


id: GO:0050965
name: detection of temperature stimulus involved in sensory perception of pain
namespace: biological_process
def:
  "The series of events involved in the perception of pain in which a temperature stimulus is received and converted into a molecular signal." [GOC:ai, GOC:dos]


id: GO:0050966
name: detection of mechanical stimulus involved in sensory perception of pain
namespace: biological_process
def:
  "The series of events involved in the perception of pain in which a mechanical stimulus is received and converted into a molecular signal." [GOC:ai, GOC:dos]


id: GO:0050967
name: detection of electrical stimulus involved in sensory perception of pain
namespace: biological_process
def:
  "The series of events that contribute to the perception of pain in which an electrical stimulus is received and converted into a molecular signal." [GOC:ai, GOC:dos, GOC:dph, GOC:tb]


id: GO:0050968
name: detection of chemical stimulus involved in sensory perception of pain
namespace: biological_process
def:
  "The series of events involved in the perception of pain in which a chemical stimulus is received and converted into a molecular signal." [GOC:ai]


id: GO:0050969
name: detection of chemical stimulus involved in magnetoreception
namespace: biological_process
def:
  "The series of events involved in magnetoception in which a chemical stimulus is received and converted into a molecular signal. It is believed that organisms such as birds and salamanders interpret product ratios in chemical reactions which involve transitions between different spin states." [GOC:ai, GOC:dos]


id: GO:0050970
name: detection of electrical stimulus involved in magnetoreception
namespace: biological_process
def:
  "The series of events that contribute to magnetoception in which an electrical stimulus is received and converted into a molecular signal. The stimulus is in the form of an induced electric field resulting from movement in a magnetic field." [GOC:ai, GOC:dos, GOC:dph, GOC:tb, PMID:15886990, Wikipedia:Magnetoception]


id: GO:0050971
name: detection of mechanical stimulus involved in magnetoreception
namespace: biological_process
def:
  "The series of events involved in magnetoception in which a mechanical stimulus is received and converted into a molecular signal. The stimulus is in the form of torque on particles such as magnetite which respond to a magnetic field." [GOC:ai, GOC:dos]


id: GO:0050972
name: detection of mechanical stimulus involved in echolocation
namespace: biological_process
def:
  "The series of events involved in echolocation in which a mechanical stimulus is received and converted into a molecular signal. The stimulus is in the form of a reflected sound wave (an echo), which the organism uses to determine the distance to the object that reflected the sound wave." [GOC:ai, GOC:dos]


id: GO:0050973
name: detection of mechanical stimulus involved in equilibrioception
namespace: biological_process
def:
  "The series of events involved in equilibrioception in which a mechanical stimulus is received and converted into a molecular signal. During equilibrioception, mechanical stimuli may be in the form of input from pressure receptors or from the labyrinth system of the inner ears." [GOC:ai, GOC:dos]


id: GO:0050974
name: detection of mechanical stimulus involved in sensory perception
namespace: biological_process
def:
  "The series of events in which a mechanical stimulus is received and converted into a molecular signal as part of sensory perception." [GOC:ai, GOC:dos]


id: GO:0050975
name: sensory perception of touch
namespace: biological_process
def:
  "The series of events required for an organism to receive a touch stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process. The perception of touch in animals is mediated by mechanoreceptors in the skin and mucous membranes and is the sense by which contact with objects gives evidence as to certain of their qualities. Different types of touch can be perceived (for example, light, coarse, pressure and tickling) and the stimulus may be external or internal (e.g. the feeling of a full stomach)." [GOC:ai]


id: GO:0050976
name: detection of mechanical stimulus involved in sensory perception of touch
namespace: biological_process
def:
  "The series of events involved in the perception of touch in which a mechanical stimulus is received and converted into a molecular signal." [GOC:ai, GOC:dos]


id: GO:0050977
name: magnetoreception by sensory perception of chemical stimulus
namespace: biological_process
def:
  "The series of events required for an organism to receive a chemical stimulus relating to a magnetic field, convert it to a molecular signal, and recognize and characterize the signal. It is believed that organisms such as birds and salamanders use a 'chemical compass': chemical reactions that involve transitions between different spin states can be influenced by magnetic fields and by detecting the different product ratios, these organisms can perceive the direction of the magnetic field. The mechanism by which this is detected is not certain but it may also involve light stimuli." [GOC:ai, PMID:15886990, Wikipedia:Magnetoception]


id: GO:0050978
name: magnetoreception by sensory perception of electrical stimulus
namespace: biological_process
def:
  "The series of events required for an organism to receive an electrical stimulus relating to a magnetic field, convert it to a molecular signal, and recognize and characterize the signal. Movement in a magnetic field results in an induced electric field, which can be perceived by organisms such as elasmobranch fish." [GOC:ai, PMID:15886990, Wikipedia:Magnetoception]


id: GO:0050979
name: magnetoreception by sensory perception of mechanical stimulus
namespace: biological_process
def:
  "The series of events required for an organism to receive a mechanical stimulus relating to a magnetic field, convert it to a molecular signal, and recognize and characterize the signal. A magnetic field exerts a torque on a ferromagnetic material (e.g. magnetite) or on a material with diamagnetic anisotropy; organisms that can detect this torque can use it to determine the orientation of the magnetic field." [GOC:ai, PMID:15886990, Wikipedia:Magnetoception]


id: GO:0050980
name: detection of light stimulus involved in magnetoreception
namespace: biological_process
def:
  "The series of events involved in magnetoception in which a light stimulus is received and converted into a molecular signal. Downstream processing of the light information in addition to other sensory data allows organisms to perceive the orientation of a magnetic field." [GOC:ai, GOC:dos, PMID:15886990, Wikipedia:Magnetoception]


id: GO:0050981
name: detection of electrical stimulus
namespace: biological_process
def:
  "The series of events by which an electrical stimulus is received and converted into a molecular signal." [GOC:ai, GOC:dos]


id: GO:0050982
name: detection of mechanical stimulus
namespace: biological_process
def:
  "The series of events by which a mechanical stimulus is received and converted into a molecular signal." [GOC:ai, GOC:dos]


id: GO:0050983
name: deoxyhypusine biosynthetic process from spermidine
namespace: biological_process
def:
  "The chemical reactions resulting in the formation of deoxyhypusine from spermidine by the enzyme [eIF-5A]-deoxyhypusine synthase. The reaction occurs in four steps: 1. spermidine + NAD+ = dehydrospermidine + NADH + H+; 2. dehydrospermidine + [enzyme]-lysine = 1,3-diaminopropane + [enzyme]-lysine-N6=CH(CH2)3NH2; 3. [enzyme]-lysine-N6=CH(CH2)3NH2 = [eIF-5A]-lysine-N6=CH(CH2)3NH2; 4. [eIF-5A]-lysine-N6=CH(CH2)3NH2 + NADH + H+ = [eIF-5A]-deoxyhypusine + NAD+." [MetaCyc:1.1.1.249-RXN]


id: GO:0050986
name: isopeptide cross-linking via N-(L-isoglutamyl)-glycine
namespace: biological_process
def:
  "The formation of an isopeptide cross-link between peptidyl-glutamate and peptidyl-glycine to produce N-(L-isoglutamyl)-glycine, as found in the antibiotic microcin J25." [PMID:14531691, RESID:AA0360]


id: GO:0050988
name: N-terminal peptidyl-methionine carboxylation
namespace: biological_process
def:
  "The carboxylation of the N-terminal methionine of proteins to form the derivative N-carboxy-L-methionine." [RESID:AA0363]


id: GO:0050992
name: dimethylallyl diphosphate biosynthetic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of dimethylallyl diphosphate." [GOC:ai]


id: GO:0050994
name: regulation of lipid catabolic process
namespace: biological_process
def:
  "Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of lipids." [GOC:ai]


id: GO:0050995
name: negative regulation of lipid catabolic process
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of lipids." [GOC:ai]


id: GO:0050996
name: positive regulation of lipid catabolic process
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of lipids." [GOC:ai]


id: GO:0050997
name: quaternary ammonium group binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with a quaternary ammonium group, including glycine betaine, choline, carnitine and proline. A quaternary ammonium group is any compound that can be regarded as derived from ammonium hydroxide or an ammonium salt by replacement of all four hydrogen atoms of the NH4+ ion by organic groups." [GOC:ai]


id: GO:0051000
name: positive regulation of nitric-oxide synthase activity
namespace: biological_process
def:
  "Any process that activates or increases the activity of the enzyme nitric-oxide synthase." [GOC:ai]


id: GO:0051002
name: ligase activity, forming nitrogen-metal bonds
namespace: molecular_function
def:
  "Catalysis of the joining of a metal ion to a molecule via a nitrogen-metal bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [EC:6.6, GOC:mah]


id: GO:0051003
name: ligase activity, forming nitrogen-metal bonds, forming coordination complexes
namespace: molecular_function
def:
  "Catalysis of the ligation of two substances via a nitrogen-metal bond, forming a coordination complex." [EC:6.6.1.-]


id: GO:0051008
name: Hsp27 protein binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with Hsp27 proteins, a lightweight heat shock protein." [GOC:ai]


id: GO:0051009
name: O-acetylhomoserine sulfhydrylase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: O-acetyl-L-homoserine + hydrogen sulfide = homocysteine + acetate." [MetaCyc:ACETYLHOMOSER-CYS-RXN, RHEA:27825]


id: GO:0051010
name: microtubule plus-end binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with the plus end of a microtubule." [GOC:ai, PMID:14557818, PMID:14614826]


id: GO:0051011
name: microtubule minus-end binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with the minus end of a microtubule." [GOC:ai, PMID:14557818, PMID:14614826]


id: GO:0051014
name: actin filament severing
namespace: biological_process
def:
  "The process in which an actin filament is broken down into smaller filaments." [GOC:ai, PMID:14657234]


id: GO:0051015
name: actin filament binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits." [ISBN:0198506732]


id: GO:0051016
name: barbed-end actin filament capping
namespace: biological_process
def:
  "The binding of a protein or protein complex to the barbed (or plus) end of an actin filament, thus preventing the addition, exchange or removal of further actin subunits." [ISBN:071673706X]


id: GO:0051017
name: actin filament bundle assembly
namespace: biological_process
def:
  "The assembly of actin filament bundles; actin filaments are on the same axis but may be oriented with the same or opposite polarities and may be packed with different levels of tightness." [GOC:ai]


id: GO:0051020
name: GTPase binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with a GTPase, any enzyme that catalyzes the hydrolysis of GTP." [GOC:ai]


id: GO:0051022
name: Rho GDP-dissociation inhibitor binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with a Rho GDP-dissociation inhibitor protein." [GOC:ai]


id: GO:0051023
name: regulation of immunoglobulin secretion
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of the regulated release of immunoglobulins from a cell." [GOC:ai]


id: GO:0051024
name: positive regulation of immunoglobulin secretion
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of the regulated release of immunoglobulins from a cell." [GOC:ai]


id: GO:0051025
name: negative regulation of immunoglobulin secretion
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of immunoglobulins from a cell." [GOC:ai]


id: GO:0051026
name: chiasma assembly
namespace: biological_process
def:
  "The cell cycle process in which a connection between chromatids assembles, indicating where an exchange of homologous segments has taken place by the crossing-over of non-sister chromatids." [http://www.onelook.com]


id: GO:0051027
name: DNA transport
namespace: biological_process
def:
  "The directed movement of RNA, deoxyribonucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]


id: GO:0051028
name: mRNA transport
namespace: biological_process
def:
  "The directed movement of mRNA, messenger ribonucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]


id: GO:0051029
name: rRNA transport
namespace: biological_process
def:
  "The directed movement of rRNA, ribosomal ribonucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]


id: GO:0051030
name: snRNA transport
namespace: biological_process
def:
  "The directed movement of snRNA, small nuclear ribonucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]


id: GO:0051031
name: tRNA transport
namespace: biological_process
def:
  "The directed movement of tRNA, transfer ribonucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]


id: GO:0051032
name: nucleic acid transmembrane transporter activity
namespace: molecular_function
def:
  "Enables the transfer of nucleic acids from one side of a membrane to the other. Nucleic acids are single or double-stranded polynucleotides involved in the storage, transmission and transfer of genetic information." [GOC:ai]


id: GO:0051034
name: tRNA transmembrane transporter activity
namespace: molecular_function
def:
  "Enables the transfer of tRNA, transfer ribonucleic acid, from one side of a membrane to the other." [GOC:ai]


id: GO:0051035
name: DNA transmembrane transporter activity
namespace: molecular_function
def:
  "Enables the transfer of DNA, deoxyribonucleic acid, from one side of a membrane to the other." [GOC:ai]


id: GO:0051036
name: regulation of endosome size
namespace: biological_process
def:
  "Any process that modulates the volume of an endosome, a membrane-bounded organelle that carries materials newly ingested by endocytosis." [GOC:ai]


id: GO:0051037
name: regulation of transcription involved in meiotic cell cycle
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of transcription as part of a meiotic cell cycle." [GOC:go_curators]


id: GO:0051038
name: negative regulation of transcription involved in meiotic cell cycle
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of transcription involved in the meiotic cell cycle." [GOC:ai]


id: GO:0051039
name: positive regulation of transcription involved in meiotic cell cycle
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of transcription as part of a meiotic cell cycle." [GOC:ai]


id: GO:0051040
name: regulation of calcium-independent cell-cell adhesion
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of the attachment of one cell to another cell via adhesion molecules that do not require the presence of calcium for the interaction." [GOC:ai]


id: GO:0051041
name: positive regulation of calcium-independent cell-cell adhesion
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of calcium-independent cell-cell adhesion." [GOC:ai]


id: GO:0051042
name: negative regulation of calcium-independent cell-cell adhesion
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of calcium-independent cell-cell adhesion." [GOC:ai]


id: GO:0051043
name: regulation of membrane protein ectodomain proteolysis
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of the proteolytic cleavage of transmembrane proteins and release of their ectodomain (extracellular domain)." [GOC:ai]


id: GO:0051044
name: positive regulation of membrane protein ectodomain proteolysis
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of membrane protein ectodomain peptidolysis." [GOC:ai]


id: GO:0051045
name: negative regulation of membrane protein ectodomain proteolysis
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of membrane protein ectodomain proteolysis." [GOC:ai]


id: GO:0051046
name: regulation of secretion
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of the controlled release of a substance from a cell or a tissue." [GOC:ai]


id: GO:0051047
name: positive regulation of secretion
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of the controlled release of a substance from a cell or a tissue." [GOC:ai]


id: GO:0051048
name: negative regulation of secretion
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of the controlled release of a substance from a cell or a tissue." [GOC:ai]


id: GO:0051049
name: regulation of transport
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]


id: GO:0051050
name: positive regulation of transport
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]


id: GO:0051051
name: negative regulation of transport
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]


id: GO:0051052
name: regulation of DNA metabolic process
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving DNA." [GOC:ai]


id: GO:0051053
name: negative regulation of DNA metabolic process
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving DNA." [GOC:ai]


id: GO:0051054
name: positive regulation of DNA metabolic process
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving DNA." [GOC:ai]


id: GO:0051055
name: negative regulation of lipid biosynthetic process
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of lipids." [GOC:ai]


id: GO:0051056
name: regulation of small GTPase mediated signal transduction
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of small GTPase mediated signal transduction." [GOC:go_curators]


id: GO:0051057
name: positive regulation of small GTPase mediated signal transduction
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of small GTPase mediated signal transduction." [GOC:ai]


id: GO:0051058
name: negative regulation of small GTPase mediated signal transduction
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of small GTPase mediated signal transduction." [GOC:ai]


id: GO:0051059
name: NF-kappaB binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with NF-kappaB, a transcription factor for eukaryotic RNA polymerase II promoters." [GOC:ai]


id: GO:0051060
name: pullulanase activity
namespace: molecular_function
def:
  "Catalysis of the hydrolysis of (1,6)-alpha-D-glucosidic linkages in pullulan (a linear polymer of alpha-(1,6)-linked maltotriose units) and in amylopectin and glycogen, and the a- and b-limit dextrins of amylopectin and glycogen." [EC:3.2.1.41]


id: GO:0051061
name: ADP reductase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: dADP + thioredoxin disulfide + H2O = ADP + thioredoxin." [MetaCyc:ADPREDUCT-RXN]


id: GO:0051062
name: UDP reductase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: dUDP + thioredoxin disulfide + H2O = UDP + thioredoxin." [MetaCyc:UDPREDUCT-RXN]


id: GO:0051063
name: CDP reductase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: dCDP + thioredoxin disulfide + H2O = CDP + thioredoxin." [MetaCyc:CDPREDUCT-RXN]


id: GO:0051064
name: TTP reductase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: dTTP + thioredoxin disulfide + H2O = TTP + thioredoxin. Thioredoxin disulfide is the oxidized form of thioredoxin." [MetaCyc:1.17.4.2-RXN]


id: GO:0051065
name: CTP reductase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: dCTP + thioredoxin disulfide + H2O = CTP + thioredoxin. Thioredoxin disulfide is the oxidized form of thioredoxin." [MetaCyc:1.17.4.2-RXN]


id: GO:0051066
name: dihydrobiopterin metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving a dihydrobiopterin, a reduced pteridine derivative related to folic acid; it acts as an electron carrier in tyrosine biosynthesis and its quinoid form is produced by oxidation of tetrahydrobiopterin in several biological hydroxylation reactions." [CHEBI:38797, http://www.onelook.com]


id: GO:0051067
name: dihydropteridine metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving 6,7-dihydropteridine, a bicyclic compound with the formula C6H6N4." [CHEBI:30156, GOC:ai]


id: GO:0051068
name: dihydrolipoamide metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving dihydrolipoamide, the reduced form of lipoamide, produced as an intermediate in the reactions in which lipoamide acts as a cofactor." [ISBN:0721601464]


id: GO:0051069
name: galactomannan metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving galactomannan, a polysaccharide composed of D-galactose and D-mannose. The mannose units form the backbone structure (a linear main chain) with the D-galactose as single side units." [http://www.els.net/els/public/glossary/]


id: GO:0051070
name: galactomannan biosynthetic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of galactomannan, a polysaccharide composed of D-galactosyl and D-mannosyl. The mannosyl units form the backbone structure (a linear main chain) with the D-galactosyl as single side units." [GOC:ai]


id: GO:0051071
name: 4,6-pyruvylated galactose residue metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving the pyruvylated galactose residue 4-6-O-[(R)(1-carboxyethylidine)]-Gal-beta-1,3-. The galactose residue is part of a larger polysaccharide chain." [GOC:ai, PMID:15173185]


id: GO:0051072
name: 4,6-pyruvylated galactose residue biosynthetic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of the pyruvylated galactose residue 4-6-O-[(R)(1-carboxyethylidine)]-Gal-beta-1,3-. The galactose residue is part of a larger polysaccharide chain." [GOC:ai, PMID:15173185]


id: GO:0051073
name: adenosylcobinamide-GDP ribazoletransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: adenosylcobinamide-GDP + alpha-ribazole = GMP + adenosylcobalamin." [EC:2.7.8.26, MetaCyc:COBALAMINSYN-RXN]


id: GO:0051074
name: obsolete protein tetramerization activity
namespace: molecular_function
def:
  "OBSOLETE. The formation of a protein tetramer, a macromolecular structure consisting of four noncovalently associated identical or nonidentical subunits." [GOC:ecd]


id: GO:0051075
name: S-adenosylmethionine:tRNA ribosyltransferase-isomerase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: S-adenosylmethionine + 7-(aminomethyl)-7-deazaguanosine-tRNA = adenine + methionine + epoxyqueuosine-tRNA. 7-(aminomethyl)-7-deazaguanosine-tRNA is also known as preQ1-tRNA, and epoxyqueuosine-tRNA as oQ-tRNA." [PMID:12731872]


id: GO:0051077
name: secondary cell septum
namespace: cellular_component
def:
  "Cell wall structures composed of linear polysaccharides which are deposited at both sides of the primary septum at 90 degrees to the primary septum." [GOC:mtg_sensu, PMID:15194814]


id: GO:0051078
name: meiotic nuclear envelope disassembly
namespace: biological_process
def:
  "The cell cycle process in which the controlled breakdown of the nuclear envelope during meiotic cell division occurs." [GOC:bf]


id: GO:0051083
name: 'de novo' cotranslational protein folding
namespace: biological_process
def:
  "The process of assisting in the correct noncovalent assembly of the ribosome-bound nascent chains of a multidomain protein whilst other parts of the protein are still being translated." [GOC:rb]


id: GO:0051084
name: 'de novo' posttranslational protein folding
namespace: biological_process
def:
  "The process of assisting in the correct noncovalent folding of newly formed polypeptides or folding intermediates of polypeptides that have exited the ribosome and/or have been stabilized and transferred by other chaperone proteins. This process could involve several cycles of ATP hydrolysis." [GOC:rb]


id: GO:0051085
name: chaperone mediated protein folding requiring cofactor
namespace: biological_process
def:
  "The process of assisting in the correct posttranslational noncovalent assembly of proteins, which is dependent on additional protein cofactors. This process occurs over one or several cycles of nucleotide hydrolysis-dependent binding and release." [GOC:rb]


id: GO:0051086
name: chaperone mediated protein folding independent of cofactor
namespace: biological_process
def:
  "The process of assisting in the correct noncovalent assembly of posttranslational proteins and does not depend on additional protein cofactors. This function occurs over one or more cycles of nucleotide-dependent binding and release." [GOC:rb]


id: GO:0051087
name: chaperone binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with a chaperone protein, a class of proteins that bind to nascent or unfolded polypeptides and ensure correct folding or transport." [http://www.onelook.com]


id: GO:0051088
name: PMA-inducible membrane protein ectodomain proteolysis
namespace: biological_process
def:
  "The proteolytic cleavage of transmembrane proteins and release of their ectodomain that occurs after induction by phorbol-12-myristate-13-acetate (PMA), a protein kinase C agonist." [PMID:12714508]


id: GO:0051089
name: constitutive protein ectodomain proteolysis
namespace: biological_process
def:
  "The proteolytic cleavage of transmembrane proteins and release of their ectodomain that occurs constantly, regardless of environmental conditions or demands." [PMID:12714508]


id: GO:0051090
name: regulation of sequence-specific DNA binding transcription factor activity
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of the activity of a transcription factor, any factor involved in the initiation or regulation of transcription." [GOC:ai]


id: GO:0051091
name: positive regulation of sequence-specific DNA binding transcription factor activity
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of activity of a transcription factor, any factor involved in the initiation or regulation of transcription." [GOC:ai]


id: GO:0051092
name: positive regulation of NF-kappaB transcription factor activity
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of activity of the transcription factor NF-kappaB." [GOC:dph, GOC:tb, PMID:15087454, PMID:15170030]


id: GO:0051093
name: negative regulation of developmental process
namespace: biological_process
def:
  "Any process that stops, prevents or reduces the rate or extent of development, the biological process whose specific outcome is the progression of an organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:ai]


id: GO:0051094
name: positive regulation of developmental process
namespace: biological_process
def:
  "Any process that activates or increases the rate or extent of development, the biological process whose specific outcome is the progression of an organism over time from an initial condition (e.g. a zygote, or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:ai]


id: GO:0051098
name: regulation of binding
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of binding, the selective interaction of a molecule with one or more specific sites on another molecule." [GOC:ai]


id: GO:0051099
name: positive regulation of binding
namespace: biological_process
def:
  "Any process that activates or increases the rate or extent of binding, the selective interaction of a molecule with one or more specific sites on another molecule." [GOC:ai]


id: GO:0051100
name: negative regulation of binding
namespace: biological_process
def:
  "Any process that stops or reduces the rate or extent of binding, the selective interaction of a molecule with one or more specific sites on another molecule." [GOC:ai]


id: GO:0051101
name: regulation of DNA binding
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of DNA binding. DNA binding is any process in which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:ai, GOC:dph, GOC:tb]


id: GO:0051102
name: DNA ligation involved in DNA recombination
namespace: biological_process
def:
  "The re-formation of a broken phosphodiester bond in the DNA backbone, carried out by DNA ligase, that contributes to DNA recombination." [GOC:ai]


id: GO:0051103
name: DNA ligation involved in DNA repair
namespace: biological_process
def:
  "The re-formation of a broken phosphodiester bond in the DNA backbone, carried out by DNA ligase, that contributes to DNA repair." [GOC:ai]


id: GO:0051104
name: DNA-dependent DNA replication DNA ligation
namespace: biological_process
def:
  "The re-formation of a broken phosphodiester bond in the DNA backbone, carried out by DNA ligase, that contributes to DNA-dependent DNA replication." [GOC:ai, GOC:dph, GOC:tb]


id: GO:0051105
name: regulation of DNA ligation
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of DNA ligation, the re-formation of a broken phosphodiester bond in the DNA backbone, carried out by DNA ligase." [GOC:ai]


id: GO:0051106
name: positive regulation of DNA ligation
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of DNA ligation, the re-formation of a broken phosphodiester bond in the DNA backbone, carried out by DNA ligase." [GOC:ai]


id: GO:0051107
name: negative regulation of DNA ligation
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of DNA ligation, the re-formation of a broken phosphodiester bond in the DNA backbone, carried out by DNA ligase." [GOC:ai]


id: GO:0051108
name: carnitine-CoA ligase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: D-carnitine + CoA + ATP = AMP + diphosphate + D-carnitinyl-CoA." [MetaCyc:DCARNCOALIG-RXN]


id: GO:0051109
name: crotonobetaine-CoA ligase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: CoA + crotono-betaine + ATP = AMP + diphosphate + crotonobetainyl-CoA." [MetaCyc:CROTCOALIG-RXN]


id: GO:0051110
name: peptidyl-histidine uridylylation, to form peptidyl-1'-(phospho-5'-uridine)-L-histidine
namespace: biological_process
def:
  "The uridylylation of peptidyl-histidine to form peptidyl-1'-(phospho-5'-uridine)-L-histidine (otherwise known as tau-UMP-histidine, tele-UMP-histidine)." [RESID:AA0372]


id: GO:0051111
name: peptidyl-histidine adenylylation
namespace: biological_process
def:
  "The adenylylation of peptidyl-histidine to form peptidyl-1'-(phospho-5'-adenosine)-L-histidine (otherwise known as tau-AMP-histidine, tele-AMP-histidine) or peptidyl-3'-(phospho-5'-adenosine)-L-histidine (otherwise known as pi-AMP-histidine, pros-AMP-histidine)." [RESID:AA0371]


id: GO:0051112
name: peptidyl-histidine adenylylation, to form peptidyl-1'-(phospho-5'-adenosine)-L-histidine
namespace: biological_process
def:
  "The adenylylation of peptidyl-histidine to form peptidyl-1'-(phospho-5'-adenosine)-L-histidine (otherwise known as tau-AMP-histidine, tele-AMP-histidine)." [RESID:AA0371]


id: GO:0051113
name: enzyme active site formation via 1'-(phospho-5'-adenosine)-L-histidine
namespace: biological_process
def:
  "The transient adenylylation of peptidyl-histidine to form 1'-(phospho-5'-adenosine)-L-histidine (otherwise known as tau-AMP-histidine, tele-AMP-histidine)." [RESID:AA0371]


id: GO:0051114
name: peptidyl-histidine uridylylation
namespace: biological_process
def:
  "The uridylylation of peptidyl-histidine to form peptidyl-1'-(phospho-5'-uridine)-L-histidine (otherwise known as tau-UMP-histidine, tele-UMP-histidine) or peptidyl-3'-(phospho-5'-uridine)-L-histidine (otherwise known as pi-UMP-histidine, pros-UMP-histidine)." [RESID:AA0372]


id: GO:0051115
name: enzyme active site formation via 1'-(phospho-5'-uridine)-L-histidine
namespace: biological_process
def:
  "The transient uridylylation of peptidyl-histidine to form 1'-(phospho-5'-uridine)-L-histidine (otherwise known as tau-UMP-histidine, tele-UMP-histidine)." [RESID:AA0372]


id: GO:0051116
name: cobaltochelatase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: ATP + Co(2+) + H(2)O + hydrogenobyrinate a,c-diamide = ADP + cob(II)yrinate a,c diamide + 4 H(+) + phosphate." [EC:6.6.1.2, RHEA:15344]


id: GO:0051117
name: ATPase binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with an ATPase, any enzyme that catalyzes the hydrolysis of ATP." [GOC:ai]


id: GO:0051118
name: glucan endo-1,3-alpha-glucosidase activity
namespace: molecular_function
def:
  "Catalysis of the endohydrolysis of (1->3)-alpha-D-glucosidic linkages in isolichenin, pseudonigeran and nigeran." [EC:3.2.1.59]


id: GO:0051119
name: sugar transmembrane transporter activity
namespace: molecular_function
def:
  "Catalysis of the transfer of a sugar from one side of the membrane to the other. A sugar is any member of a class of sweet, water-soluble, crystallizable carbohydrates, which are the monosaccharides and smaller oligosaccharides." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]


id: GO:0051120
name: hepoxilin A3 synthase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 12S-5Z,8Z,10E,14Z-12-hydro(pero)xy-eicosa-5,8,10,14-tetraenoic acid = (5Z,9E,14Z)-(8,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoate. 12S-5Z,8Z,10E,14Z-12-hydro(pero)xy-eicosa-5,8,10,14-tetraenoic acid is also known as 12S-HpETE, and (5Z,9E,14Z)-(8,11R,12S)-11,12-epoxy-8-hydroxyicosa-5,9,14-trienoate as hepoxilin A3." [PMID:15123652]


id: GO:0051121
name: hepoxilin metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving hepoxilins, a class of bioactive icosanoids with roles in the regulation of cell physiology." [PMID:15123652]


id: GO:0051122
name: hepoxilin biosynthetic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of hepoxilins, a class of bioactive icosanoids with roles in the regulation of cell physiology." [GOC:ai]


id: GO:0051123
name: RNA polymerase II transcriptional preinitiation complex assembly
namespace: biological_process
def:
  "The aggregation, arrangement and bonding together of proteins on an RNA polymerase II promoter DNA to form the transcriptional preinitiation complex (PIC), the formation of which is a prerequisite for transcription by RNA polymerase." [GOC:txnOH, PMID:10882737, PMID:15020047]


id: GO:0051124
name: synaptic growth at neuromuscular junction
namespace: biological_process
def:
  "The growth of a synapse at a neuromuscular junction, the site of apposition of a motor end plate and the subneural cleft of the skeletal muscle fiber that it innervates." [ISBN:0721662544]


id: GO:0051125
name: regulation of actin nucleation
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of actin nucleation, the initial step in the formation of an actin filament in which actin monomers combine to form a new filament." [GOC:ai]


id: GO:0051126
name: negative regulation of actin nucleation
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of actin nucleation, the initial step in the formation of an actin filament in which actin monomers combine to form a new filament." [GOC:ai]


id: GO:0051127
name: positive regulation of actin nucleation
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of actin nucleation, the initial step in the formation of an actin filament in which actin monomers combine to form a new filament." [GOC:ai]


id: GO:0051128
name: regulation of cellular component organization
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope." [GOC:ai]


id: GO:0051129
name: negative regulation of cellular component organization
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope." [GOC:ai]


id: GO:0051130
name: positive regulation of cellular component organization
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell structures, including the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope." [GOC:ai]


id: GO:0051131
name: chaperone-mediated protein complex assembly
namespace: biological_process
def:
  "The aggregation, arrangement and bonding together of a set of components to form a protein complex, mediated by chaperone molecules that do not form part of the finished complex." [GOC:ai]


id: GO:0051132
name: NK T cell activation
namespace: biological_process
def:
  "The change in morphology and behavior of a mature or immature natural killer T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific." [ISBN:0781735149, PMID:12154375, PMID:9133426]


id: GO:0051133
name: regulation of NK T cell activation
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of natural killer T cell activation." [ISBN:0781735149, PMID:12154375, PMID:9133426]


id: GO:0051134
name: negative regulation of NK T cell activation
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of natural killer T cell activation." [ISBN:0781735149, PMID:12154375, PMID:9133426]


id: GO:0051135
name: positive regulation of NK T cell activation
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of natural killer T cell activation." [ISBN:0781735149, PMID:12154375, PMID:9133426]


id: GO:0051136
name: regulation of NK T cell differentiation
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of natural killer T cell differentiation." [ISBN:0781735149, PMID:12154375, PMID:9133426]


id: GO:0051137
name: negative regulation of NK T cell differentiation
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of natural killer T cell differentiation." [ISBN:0781735149, PMID:12154375, PMID:9133426]


id: GO:0051138
name: positive regulation of NK T cell differentiation
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of natural killer T cell differentiation." [ISBN:0781735149, PMID:12154375, PMID:9133426]


id: GO:0051139
name: metal ion:proton antiporter activity
namespace: molecular_function
def:
  "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: metal ion(in) + H+(out) = metal ion(out) + H+(in)." [GOC:mlg]


id: GO:0051140
name: regulation of NK T cell proliferation
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of natural killer T cell proliferation." [ISBN:0781735149, PMID:12154375, PMID:9133426]


id: GO:0051141
name: negative regulation of NK T cell proliferation
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of natural killer T cell proliferation." [ISBN:0781735149, PMID:12154375, PMID:9133426]


id: GO:0051142
name: positive regulation of NK T cell proliferation
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of natural killer T cell proliferation." [ISBN:0781735149, PMID:12154375, PMID:9133426]


id: GO:0051143
name: propanediol metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving propanediol, CH3-CHOH-CH2OH, a sweet, colorless, viscous, hygroscopic liquid used as an antifreeze, in brake fluid and as a humectant in cosmetics and personal care items." [http://www.onelook.com]


id: GO:0051144
name: propanediol catabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the breakdown of propanediol, a sweet, colorless, viscous, hygroscopic liquid with the formula CH3-CHOH-CH2OH." [GOC:ai]


id: GO:0051145
name: smooth muscle cell differentiation
namespace: biological_process
def:
  "The process in which a relatively unspecialized cell acquires specialized features of a smooth muscle cell; smooth muscle lacks transverse striations in its constituent fibers and are almost always involuntary." [CL:0000192, GOC:ai]


id: GO:0051146
name: striated muscle cell differentiation
namespace: biological_process
def:
  "The process in which a relatively unspecialized cell acquires specialized features of a striated muscle cell; striated muscle fibers are divided by transverse bands into striations, and cardiac and voluntary muscle are types of striated muscle." [CL:0000737, GOC:ai]


id: GO:0051147
name: regulation of muscle cell differentiation
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of muscle cell differentiation." [CL:0000187, GOC:ai]


id: GO:0051148
name: negative regulation of muscle cell differentiation
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of muscle cell differentiation." [CL:0000187, GOC:ai]


id: GO:0051149
name: positive regulation of muscle cell differentiation
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of muscle cell differentiation." [CL:0000187, GOC:ai]


id: GO:0051150
name: regulation of smooth muscle cell differentiation
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of smooth muscle cell differentiation." [CL:0000192, GOC:ai]


id: GO:0051151
name: negative regulation of smooth muscle cell differentiation
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of smooth muscle cell differentiation." [CL:0000192, GOC:ai]


id: GO:0051152
name: positive regulation of smooth muscle cell differentiation
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of smooth muscle cell differentiation." [CL:0000192, GOC:ai]


id: GO:0051153
name: regulation of striated muscle cell differentiation
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of striated muscle cell differentiation." [CL:0000737, GOC:ai]


id: GO:0051154
name: negative regulation of striated muscle cell differentiation
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of striated muscle cell differentiation." [CL:0000737, GOC:ai]


id: GO:0051155
name: positive regulation of striated muscle cell differentiation
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of striated muscle cell differentiation." [CL:0000737, GOC:ai]


id: GO:0051156
name: glucose 6-phosphate metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving glucose 6-phosphate, a monophosphorylated derivative of glucose with the phosphate group attached to C-6." [GOC:ai]


id: GO:0051157
name: arabitol catabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the breakdown of arabitol, the pentitol derived from arabinose or lyxose by reduction of the aldehyde group." [ISBN:0198506732]


id: GO:0051158
name: L-arabitol catabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the breakdown of L-arabitol, the pentitol derived from arabinose or lyxose by reduction of the aldehyde group." [ISBN:0198506732]


id: GO:0051159
name: D-arabitol catabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the breakdown of D-arabitol, the pentitol derived from arabinose or lyxose by reduction of the aldehyde group. The D enantiomer is present in lichens and mushrooms." [ISBN:0198506732]


id: GO:0051160
name: L-xylitol catabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the breakdown of L-xylitol, a five-carbon sugar alcohol derived from xylose by reduction of the carbonyl group." [GOC:ai]


id: GO:0051161
name: arabitol metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving arabitol, the pentitol derived from arabinose or lyxose by reduction of the aldehyde group." [ISBN:0198506732]


id: GO:0051162
name: L-arabitol metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving L-arabitol, the pentitol derived from arabinose or lyxose by reduction of the aldehyde group." [ISBN:0198506732]


id: GO:0051163
name: D-arabitol metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving D-arabitol, the pentitol derived from arabinose or lyxose by reduction of the aldehyde group. The D enantiomer is present in lichens and mushrooms." [ISBN:0198506732]


id: GO:0051164
name: L-xylitol metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving L-xylitol, a five-carbon sugar alcohol derived from xylose by reduction of the carbonyl group. It is as sweet as sucrose and is used as a noncariogenic sweetner and as a sugar substitute in diabetic diets." [GOC:ai, http://www.onelook.com]


id: GO:0051166
name: 2,5-dihydroxypyridine catabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the breakdown of 2,5-dihydroxypyridine." [CHEBI:16364, GOC:ai]


id: GO:0051167
name: xylulose 5-phosphate metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving xylulose 5-phosphate, a derivative of the ketopentose xylulose phosphorylated at the 5 carbon; it is an intermediate in the pentose phosphate pathway." [ISBN:0721662544]


id: GO:0051171
name: regulation of nitrogen compound metabolic process
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nitrogen or nitrogenous compounds." [GOC:ai, GOC:tb]


id: GO:0051172
name: negative regulation of nitrogen compound metabolic process
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving nitrogen or nitrogenous compounds." [GOC:ai, GOC:tb]


id: GO:0051173
name: positive regulation of nitrogen compound metabolic process
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving nitrogen or nitrogenous compounds." [GOC:ai, GOC:tb]


id: GO:0051174
name: regulation of phosphorus metabolic process
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving phosphorus or compounds containing phosphorus." [GOC:ai]


id: GO:0051175
name: negative regulation of sulfur metabolic process
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving sulfur or compounds containing sulfur." [GOC:ai]


id: GO:0051176
name: positive regulation of sulfur metabolic process
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving sulfur or compounds containing sulfur." [GOC:ai]


id: GO:0051177
name: meiotic sister chromatid cohesion
namespace: biological_process
def:
  "The cell cycle process in which sister chromatids of a replicated chromosome are joined along the entire length of the chromosome during meiosis." [GOC:ai]


id: GO:0051178
name: meiotic chromosome decondensation
namespace: biological_process
def:
  "The cell cycle process in which chromosome structure is altered from the condensed form held during meiosis to the relaxed dispersed form held in resting cells." [GOC:ai]


id: GO:0051179
name: localization
namespace: biological_process
def:
  "Any process in which a cell, a substance, or a cellular entity, such as a protein complex or organelle, is transported to or maintained in a specific location." [GOC:ai]


id: GO:0051180
name: vitamin transport
namespace: biological_process
def:
  "The directed movement of vitamins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A vitamin is one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body." [GOC:ai]


id: GO:0051181
name: cofactor transport
namespace: biological_process
def:
  "The directed movement of a cofactor into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A cofactor is a substance that is required for the activity of an enzyme or other protein." [GOC:ai]


id: GO:0051182
name: coenzyme transport
namespace: biological_process
def:
  "The directed movement of a coenzyme into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A coenzyme is any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed." [GOC:ai]


id: GO:0051183
name: vitamin transporter activity
namespace: molecular_function
def:
  "Enables the directed movement of vitamins into, out of or within a cell, or between cells. A vitamin is one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body." [GOC:ai]


id: GO:0051184
name: cofactor transporter activity
namespace: molecular_function
def:
  "Enables the directed movement of a cofactor into, out of or within a cell, or between cells. A cofactor is a substance that is required for the activity of an enzyme or other protein." [GOC:ai]


id: GO:0051185
name: coenzyme transporter activity
namespace: molecular_function
def:
  "Enables the directed movement of a coenzyme into, out of or within a cell, or between cells. A coenzyme is any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed." [GOC:ai]


id: GO:0051186
name: cofactor metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving a cofactor, a substance that is required for the activity of an enzyme or other protein. Cofactors may be inorganic, such as the metal atoms zinc, iron, and copper in certain forms, or organic, in which case they are referred to as coenzymes. Cofactors may either be bound tightly to active sites or bind loosely with the substrate." [GOC:ai]


id: GO:0051187
name: cofactor catabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the breakdown of a cofactor, a substance that is required for the activity of an enzyme or other protein." [GOC:ai]


id: GO:0051188
name: cofactor biosynthetic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of a cofactor, a substance that is required for the activity of an enzyme or other protein." [GOC:ai]


id: GO:0051189
name: prosthetic group metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving a prosthetic group, the non-amino acid portion of certain protein molecules. Prosthetic groups may be inorganic or organic and are usually required for the biological activity of the protein." [GOC:ai]


id: GO:0051190
name: prosthetic group catabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the breakdown of a prosthetic group, the non-amino acid portion of certain protein molecules. Prosthetic groups may be inorganic or organic and are usually required for the biological activity of the protein." [GOC:ai]


id: GO:0051191
name: prosthetic group biosynthetic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of a prosthetic group, the non-amino acid portion of certain protein molecules. Prosthetic groups may be inorganic or organic and are usually required for the biological activity of the protein." [GOC:ai]


id: GO:0051192
name: prosthetic group binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with a prosthetic group, the non-amino acid portion of certain protein molecules. Prosthetic groups may be inorganic or organic and are usually required for the biological activity of the protein." [GOC:ai, GOC:vw]


id: GO:0051193
name: regulation of cofactor metabolic process
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a cofactor." [GOC:ai]


id: GO:0051194
name: positive regulation of cofactor metabolic process
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving a cofactor." [GOC:ai]


id: GO:0051195
name: negative regulation of cofactor metabolic process
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving a cofactor." [GOC:ai]


id: GO:0051196
name: regulation of coenzyme metabolic process
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a coenzyme." [GOC:ai]


id: GO:0051197
name: positive regulation of coenzyme metabolic process
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving a coenzyme." [GOC:ai]


id: GO:0051198
name: negative regulation of coenzyme metabolic process
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving a coenzyme." [GOC:ai]


id: GO:0051199
name: regulation of prosthetic group metabolic process
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a prosthetic group." [GOC:ai]


id: GO:0051200
name: positive regulation of prosthetic group metabolic process
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving a prosthetic group." [GOC:ai]


id: GO:0051201
name: negative regulation of prosthetic group metabolic process
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving a prosthetic group." [GOC:ai]


id: GO:0051202
name: phytochromobilin metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving phytochromobilin, the linear tetrapyrrole chromophore required for plant phytochrome photoactivity." [PMID:11500553]


id: GO:0051203
name: peptidyl-aspartic acid reduction to form L-aspartyl aldehyde
namespace: biological_process
def:
  "The reduction of peptidyl-aspartic acid to form peptidyl-L-aspartyl aldehyde, as found photosystem II P680 chlorophyll A apoprotein." [PMID:15237995, RESID:AA0373]


id: GO:0051204
name: protein insertion into mitochondrial membrane
namespace: biological_process
def:
  "The process that results in the incorporation of a protein into a mitochondrial membrane." [GOC:ai]


id: GO:0051205
name: protein insertion into membrane
namespace: biological_process
def:
  "The process that results in the incorporation of a protein into a biological membrane.  Incorporation in this context means having some part or covalently attached group that is inserted into the the hydrophobic region of one or both bilayers." [GOC:ai]


id: GO:0051206
name: silicate metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving silicates, the salts of silicic acids. Silicates are usually composed of silicon and oxygen (Si[x]O[y]), one or more metals, and possibly hydrogen. Types of silicate include unisilicates, metasilicates and hydrous silicates." [GOC:ai]


id: GO:0051208
name: sequestering of calcium ion
namespace: biological_process
def:
  "The process of binding or confining calcium ions such that they are separated from other components of a biological system." [GOC:ai]


id: GO:0051209
name: release of sequestered calcium ion into cytosol
namespace: biological_process
def:
  "The process in which calcium ions sequestered in the endoplasmic reticulum, Golgi apparatus or mitochondria are released into the cytosolic compartment." [GOC:dph, GOC:hjd, GOC:mtg_lung, PMID:1814929]


id: GO:0051210
name: isotropic cell growth
namespace: biological_process
def:
  "The process in which a cell irreversibly increases in size uniformly in all directions. In general, a rounded cell morphology reflects isotropic cell growth." [GOC:ai, GOC:jid]


id: GO:0051211
name: anisotropic cell growth
namespace: biological_process
def:
  "The process in which a cell irreversibly increases in size in one or more axes, where the growth rate varies according to the direction of growth. Growth may be limited to a particular axis, axes, or to particular locations on the surface of the cell." [GOC:ai]


id: GO:0051213
name: dioxygenase activity
namespace: molecular_function
def:
  "Catalysis of an oxidation-reduction (redox) reaction in which both atoms of oxygen from one molecule of O2 are incorporated into the (reduced) product(s) of the reaction. The two atoms of oxygen may be distributed between two different products." [DOI:10.1016/S0040-4020(03)00944-X, GOC:bf, http://www.onelook.com/]


id: GO:0051214
name: RNA virus induced gene silencing
namespace: biological_process
def:
  "Gene silencing induced by RNA viruses leading to a sequence-specific degradation of target mRNAs or post-transcriptional gene silencing." [PMID:15165191]


id: GO:0051215
name: DNA virus induced gene silencing
namespace: biological_process
def:
  "Gene silencing induced by DNA viruses leading to a sequence-specific degradation of target mRNAs or post-transcriptional gene silencing." [PMID:15165191]


id: GO:0051216
name: cartilage development
namespace: biological_process
def:
  "The process whose specific outcome is the progression of a cartilage element over time, from its formation to the mature structure. Cartilage elements are skeletal elements that consist of connective tissue dominated by extracellular matrix containing collagen type II and large amounts of proteoglycan, particularly chondroitin sulfate." [DOI:10.1371/journal.pone.0051070, GOC:cjm, http://www.onelook.com]


id: GO:0051217
name: molybdenum incorporation via L-aspartyl molybdenum bis(molybdopterin guanine dinucleotide)
namespace: biological_process
def:
  "The incorporation of molybdenum into a protein via L-aspartyl molybdenum bis(molybdopterin guanine dinucleotide)." [PDB:1Q16, PMID:12910261, RESID:AA0375]


id: GO:0051218
name: tungsten incorporation via L-selenocysteinyl tungsten bis(molybdopterin guanine dinucleotide)
namespace: biological_process
def:
  "The incorporation of tungsten into a protein via L-selenocysteinyl tungsten bis(molybdopterin guanine dinucleotide)." [PDB:1HOH, PMID:12220497, RESID:AA0376]


id: GO:0051220
name: cytoplasmic sequestering of protein
namespace: biological_process
def:
  "The selective interaction of a protein with specific molecules in the cytoplasm, thereby inhibiting its transport into other areas of the cell." [GOC:ai]


id: GO:0051222
name: positive regulation of protein transport
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of the directed movement of a protein into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]


id: GO:0051223
name: regulation of protein transport
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of the directed movement of a protein into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]


id: GO:0051224
name: negative regulation of protein transport
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of a protein into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]


id: GO:0051225
name: spindle assembly
namespace: biological_process
def:
  "The aggregation, arrangement and bonding together of a set of components to form the spindle, the array of microtubules and associated molecules that serves to move duplicated chromosomes apart." [GOC:ai, GOC:expert_rg, GOC:mtg_sensu, GOC:tb]


id: GO:0051230
name: spindle disassembly
namespace: biological_process
def:
  "The controlled breakdown of the spindle, the array of microtubules and associated molecules that serves to move duplicated chromosomes apart." [GOC:ai]


id: GO:0051232
name: meiotic spindle elongation
namespace: biological_process
def:
  "The lengthening of the distance between poles of the spindle during a meiotic cell cycle." [GOC:ai]


id: GO:0051233
name: spindle midzone
namespace: cellular_component
def:
  "The area in the center of the spindle where the spindle microtubules from opposite poles overlap." [GOC:ai, PMID:15296749]


id: GO:0051234
name: establishment of localization
namespace: biological_process
def:
  "The directed movement of a cell, substance or cellular entity, such as a protein complex or organelle, to a specific location." [GOC:ai]


id: GO:0051235
name: maintenance of location
namespace: biological_process
def:
  "Any process in which a cell, substance or cellular entity, such as a protein complex or organelle, is maintained in a location and prevented from moving elsewhere." [GOC:ai, GOC:dph, GOC:tb]


id: GO:0051237
name: maintenance of RNA location
namespace: biological_process
def:
  "Any process in which RNA is maintained in a location and prevented from moving elsewhere." [GOC:ai]


id: GO:0051238
name: sequestering of metal ion
namespace: biological_process
def:
  "The process of binding or confining metal ions such that they are separated from other components of a biological system." [GOC:ai]


id: GO:0051239
name: regulation of multicellular organismal process
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of a multicellular organismal process, the processes pertinent to the function of a multicellular organism above the cellular level; includes the integrated processes of tissues and organs." [GOC:ai, GOC:dph, GOC:tb]


id: GO:0051240
name: positive regulation of multicellular organismal process
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of an organismal process, any of the processes pertinent to the function of an organism above the cellular level; includes the integrated processes of tissues and organs." [GOC:ai]


id: GO:0051241
name: negative regulation of multicellular organismal process
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of an organismal process, the processes pertinent to the function of an organism above the cellular level; includes the integrated processes of tissues and organs." [GOC:ai]


id: GO:0051246
name: regulation of protein metabolic process
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a protein." [GOC:ai]


id: GO:0051247
name: positive regulation of protein metabolic process
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving a protein." [GOC:ai]


id: GO:0051248
name: negative regulation of protein metabolic process
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of chemical reactions and pathways involving a protein." [GOC:ai]


id: GO:0051250
name: negative regulation of lymphocyte activation
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of lymphocyte activation." [GOC:ai]


id: GO:0051251
name: positive regulation of lymphocyte activation
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of lymphocyte activation." [GOC:ai]


id: GO:0051252
name: regulation of RNA metabolic process
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving RNA." [GOC:ai]


id: GO:0051253
name: negative regulation of RNA metabolic process
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving RNA." [GOC:ai]


id: GO:0051254
name: positive regulation of RNA metabolic process
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving RNA." [GOC:ai]


id: GO:0051255
name: spindle midzone assembly
namespace: biological_process
def:
  "The cell cycle process in which aggregation, arrangement and bonding together of a set of components to form the spindle midzone. The spindle midzone is the area in the center of the spindle where the spindle microtubules from opposite poles overlap." [GOC:ai, PMID:15296749]


id: GO:0051256
name: mitotic spindle midzone assembly
namespace: biological_process
def:
  "The cell cycle process, occurring during anaphase, in which the aggregation, arrangement and bonding together of a set of components forms the spindle midzone." [GOC:mtg_cell_cycle, GOC:vw]


id: GO:0051257
name: meiotic spindle midzone assembly
namespace: biological_process
def:
  "The formation of the spindle midzone, the area in the center of the spindle where the spindle microtubules from opposite poles overlap, as a part of the process of meiosis." [GOC:ai, GOC:expert_rg, GOC:tb]


id: GO:0051258
name: protein polymerization
namespace: biological_process
def:
  "The process of creating protein polymers, compounds composed of a large number of component monomers; polymeric proteins may be made up of different or identical monomers. Polymerization occurs by the addition of extra monomers to an existing poly- or oligomeric protein." [GOC:ai]


id: GO:0051259
name: protein oligomerization
namespace: biological_process
def:
  "The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of component monomers; protein oligomers may be composed of different or identical monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer." [GOC:ai]


id: GO:0051260
name: protein homooligomerization
namespace: biological_process
def:
  "The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of identical component monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer." [GOC:ai]


id: GO:0051261
name: protein depolymerization
namespace: biological_process
def:
  "The process in which protein polymers, compounds composed of a large number of component monomers, are broken down. Depolymerization occurs by the successive removal of monomers from an existing poly- or oligomeric protein." [GOC:ai]


id: GO:0051262
name: protein tetramerization
namespace: biological_process
def:
  "The formation of a protein tetramer, a macromolecular structure consisting of four noncovalently associated identical or nonidentical subunits." [GOC:ecd]


id: GO:0051263
name: microcin E492 biosynthetic process by siderophore ester modification of peptidyl-serine
namespace: biological_process
def:
  "The modification of serine to N-[5-(6-O-seryl-beta-glucosyl)-2,3-dihydroxybenzoyl]-O-[N-(2,3-dihydroxybenzoyl)-O-[N-(2,3-dihydroxybenzoyl)seryl]seryl]serine as found in microcin E492 produced from the mceA gene in plasmid pJAM229 of the E. coli VCS257 strain and the K. pneumoniae RYC492 strain." [RESID:AA0374]


id: GO:0051264
name: mono-olein transacylation activity
namespace: molecular_function
def:
  "Catalysis of the reaction: mono-olein + mono-olein = diolein + glycerol. Mono-olein, also known as mono-oleoylglycerol, is the monoglyceride formed from oleic acid, 9-octodecenoic acid; diolein is also known as dioleoylglycerol." [GOC:ai, PMID:15364929]


id: GO:0051265
name: diolein transacylation activity
namespace: molecular_function
def:
  "Catalysis of the reaction: diolein + mono-olein = triolein + glycerol. Mono-olein, also known as mono-oleoylglycerol, is the monoglyceride formed from oleic acid, 9-octodecenoic acid; diolein is also known as dioleoylglycerol, and triolein as trioleoylglycerol and olein." [GOC:ai, PMID:15364929]


id: GO:0051267
name: CP2 mannose-ethanolamine phosphotransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: ethanolamine phosphate + Man-alpha-(1,2)-Man-alpha-(1,2)-Man-alpha-(1,6)-R = Man-alpha-(1,2)-Man-alpha-6-P-EtN-(1,2)-Man-alpha-(1,6)-R; R is Man-alpha(1,4)-GlcNH2-inositol-PO4-lipid. This reaction is the transfer of ethanolamine phosphate to C6 of second mannose in the GPI lipid precursor CP2." [PMID:14985347, PMID:15452134]


id: GO:0051268
name: alpha-keto amide reductase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: alpha-keto amide + 2 H+ (from donor) = (R)-hydroxy amide. Alpha-keto amides are of the form R-CO-CONH2, where R may be aromatic or aliphatic." [GOC:ai, PMID:15564669]


id: GO:0051269
name: alpha-keto ester reductase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: alpha-keto ester + 2 H+ (from donor) = (R)-hydroxy ester. Alpha-keto esters are of the form R(1)-CO-CO-O-R(2), where the R groups may be aromatic or aliphatic." [GOC:ai, PMID:15564669]


id: GO:0051270
name: regulation of cellular component movement
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of the movement of a cellular component." [GOC:ai, GOC:dph, GOC:jl]


id: GO:0051271
name: negative regulation of cellular component movement
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of the movement of a cellular component." [GOC:ai, GOC:dph, GOC:jl]


id: GO:0051272
name: positive regulation of cellular component movement
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of the movement of a cellular component." [GOC:ai, GOC:dph, GOC:jl]


id: GO:0051273
name: beta-glucan metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving beta-glucans, compounds composed of glucose residues linked by beta-D-glucosidic bonds." [GOC:ai]


id: GO:0051276
name: chromosome organization
namespace: biological_process
def:
  "A process that is carried out at the cellular level that results in the assembly, arrangement of constituent parts, or disassembly of chromosomes, structures composed of a very long molecule of DNA and associated proteins that carries hereditary information. This term covers covalent modifications at the molecular level as well as spatial relationships among the major components of a chromosome." [GOC:ai, GOC:dph, GOC:jl, GOC:mah]


id: GO:0051278
name: fungal-type cell wall polysaccharide biosynthetic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of the polysaccharides which make up the fungal-type cell wall." [GOC:ai, GOC:mtg_sensu]


id: GO:0051279
name: regulation of release of sequestered calcium ion into cytosol
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of the release into the cytosolic compartment of calcium ions sequestered in the endoplasmic reticulum or mitochondria." [GOC:ai, GOC:tb]


id: GO:0051280
name: negative regulation of release of sequestered calcium ion into cytosol
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of the release into the cytosolic compartment of calcium ions sequestered in the endoplasmic reticulum or mitochondria." [GOC:ai]


id: GO:0051281
name: positive regulation of release of sequestered calcium ion into cytosol
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of the release into the cytosolic compartment of calcium ions sequestered in the endoplasmic reticulum or mitochondria." [GOC:ai]


id: GO:0051282
name: regulation of sequestering of calcium ion
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of the binding or confining calcium ions such that they are separated from other components of a biological system." [GOC:ai]


id: GO:0051283
name: negative regulation of sequestering of calcium ion
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of the binding or confining calcium ions such that they are separated from other components of a biological system." [GOC:ai]


id: GO:0051284
name: positive regulation of sequestering of calcium ion
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of the binding or confining calcium ions such that they are separated from other components of a biological system." [GOC:ai]


id: GO:0051285
name: cell cortex of cell tip
namespace: cellular_component
def:
  "The region directly beneath the plasma membrane at the cell tip. The cell tip is the region at either end of the longest axis of a cylindrical or elongated cell." [GOC:ai]


id: GO:0051287
name: NAD binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH." [GOC:ai]


id: GO:0051289
name: protein homotetramerization
namespace: biological_process
def:
  "The formation of a protein homotetramer, a macromolecular structure consisting of four noncovalently associated identical subunits." [GOC:go_curators]


id: GO:0051290
name: protein heterotetramerization
namespace: biological_process
def:
  "The formation of a protein heterotetramer, a macromolecular structure consisting of four noncovalently associated subunits, of which not all are identical." [GOC:go_curators]


id: GO:0051291
name: protein heterooligomerization
namespace: biological_process
def:
  "The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of component monomers that are not all identical. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer." [GOC:ai]


id: GO:0051292
name: nuclear pore complex assembly
namespace: biological_process
def:
  "The aggregation, arrangement and bonding together of a set of components to form a nuclear pore complex." [GOC:ai, GOC:mah]


id: GO:0051295
name: establishment of meiotic spindle localization
namespace: biological_process
def:
  "The cell cycle process in which the directed movement of the meiotic spindle to a specific location in the cell occurs." [GOC:ai]


id: GO:0051296
name: establishment of meiotic spindle orientation
namespace: biological_process
def:
  "Any process that set the alignment of meiotic spindle relative to other cellular structures." [GOC:ai]


id: GO:0051297
name: centrosome organization
namespace: biological_process
def:
  "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a centrosome, a structure comprised of a pair of centrioles and peri-centriolar material from which a microtubule spindle apparatus is organized." [GOC:ai, GOC:dph, GOC:jl, GOC:mah]


id: GO:0051298
name: centrosome duplication
namespace: biological_process
def:
  "The replication of a centrosome, a structure comprised of a pair of centrioles and peri-centriolar material from which a microtubule spindle apparatus is organized." [GOC:ai]


id: GO:0051299
name: centrosome separation
namespace: biological_process
def:
  "The process in which duplicated centrosome components move away from each other. The centriole pair within each centrosome becomes part of a separate microtubule organizing center that nucleates a radial array of microtubules called an aster. The two asters move to opposite sides of the nucleus to form the two poles of the mitotic spindle." [GOC:ai]


id: GO:0051300
name: spindle pole body organization
namespace: biological_process
def:
  "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the spindle pole body (SPB). The SPB is the microtubule organizing center in fungi, and is functionally homologous to the animal cell centrosome." [GOC:ai, GOC:dph, GOC:jl, GOC:mah]


id: GO:0051301
name: cell division
namespace: biological_process
def:
  "The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells." [GOC:di, GOC:go_curators, GOC:pr]


id: GO:0051302
name: regulation of cell division
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of the physical partitioning and separation of a cell into daughter cells." [GOC:go_curators]


id: GO:0051304
name: chromosome separation
namespace: biological_process
def:
  "The cell cycle process in which paired chromosomes are detached from each other. Chromosome separation begins with the release of cohesin complexes from chromosomes; in budding yeast, this includes the cleavage of cohesin complexes along the chromosome arms, followed by the separation of the centromeric regions. Chromosome separation also includes formation of chromatid axes mediated by condensins, and ends with the disentangling of inter-sister catenation catalyzed by topoisomerase II (topo II)." [GOC:ai, GOC:lb, GOC:mah, GOC:mtg_cell_cycle, PMID:20352243]


id: GO:0051305
name: chromosome movement towards spindle pole
namespace: biological_process
def:
  "The directed movement of chromosomes in the center of the spindle towards the spindle poles, mediated by the shortening of microtubules attached to the chromosomes." [GOC:ai]


id: GO:0051306
name: mitotic sister chromatid separation
namespace: biological_process
def:
  "The process in which sister chromatids are physically detached from each other during mitosis." [GOC:ai]


id: GO:0051308
name: male meiosis chromosome separation
namespace: biological_process
def:
  "The process in which paired chromosomes are physically detached from each other during male meiosis." [GOC:ai]


id: GO:0051309
name: female meiosis chromosome separation
namespace: biological_process
def:
  "The process in which paired chromosomes are physically detached from each other during female meiosis." [GOC:ai]


id: GO:0051310
name: metaphase plate congression
namespace: biological_process
def:
  "The alignment of chromosomes at the metaphase plate (spindle equator), a plane halfway between the poles of the spindle." [GOC:ai]


id: GO:0051311
name: meiotic metaphase plate congression
namespace: biological_process
def:
  "The cell cycle process in which chromosomes are aligned at the metaphase plate, a plane halfway between the poles of the meiotic spindle, during meiosis." [GOC:ai]


id: GO:0051312
name: chromosome decondensation
namespace: biological_process
def:
  "The alteration of chromosome structure from the condensed form to a relaxed disperse form." [GOC:ai]


id: GO:0051315
name: attachment of mitotic spindle microtubules to kinetochore
namespace: biological_process
def:
  "The cell cycle process in which spindle microtubules become physically associated with the proteins making up the kinetochore complex during mitosis." [GOC:ai, GOC:clt, GOC:dph, GOC:tb, PMID:26258632, PMID:26705896]


id: GO:0051316
name: attachment of spindle microtubules to kinetochore involved in meiotic chromosome segregation
namespace: biological_process
def:
  "The cell cycle process in which spindle microtubules become physically associated with the proteins making up the kinetochore complex contributing to meiotic chromosome segregation." [GOC:ai, GOC:dph, GOC:tb]


id: GO:0051318
name: G1 phase
namespace: biological_process
def:
  "The cell cycle 'gap' phase which is the interval between the completion of DNA segregation (usually by mitosis or meiosis) and the beginning of DNA synthesis." [GOC:mtg_cell_cycle]


id: GO:0051319
name: G2 phase
namespace: biological_process
def:
  "The cell cycle 'gap' phase which is the interval between the completion of DNA synthesis and the beginning of DNA segregation (usually by mitosis or meiosis)." [GOC:mtg_cell_cycle]


id: GO:0051321
name: meiotic cell cycle
namespace: biological_process
def:
  "Progression through the phases of the meiotic cell cycle, in which canonically a cell replicates to produce four offspring with half the chromosomal content of the progenitor cell via two nuclear divisions." [GOC:ai]


id: GO:0051322
name: anaphase
namespace: biological_process
def:
  "The cell cycle phase, following metaphase, during which the chromosomes separate and migrate towards the poles of the spindle." [GOC:mtg_cell_cycle]


id: GO:0051323
name: metaphase
namespace: biological_process
def:
  "The cell cycle phase, following prophase or prometaphase in higher eukaryotes, during which chromosomes become aligned on the equatorial plate of the cell." [GOC:mtg_cell_cycle]


id: GO:0051324
name: prophase
namespace: biological_process
def:
  "The cell cycle phase which is the first stage of M phase of meiosis and mitosis and during which chromosomes condense and the two daughter centrioles and their asters migrate toward the poles of the cell." [GOC:mtg_cell_cycle]


id: GO:0051325
name: interphase
namespace: biological_process
def:
  "The cell cycle phase following cytokinesis which begins with G1 phase, proceeds through S phase and G2 phase and ends when prophase of meiosis or mitosis begins. During interphase the cell readies itself for meiosis or mitosis and the replication of its DNA occurs." [GOC:mtg_cell_cycle]


id: GO:0051326
name: telophase
namespace: biological_process
def:
  "The cell cycle phase which follows anaphase during M phase of mitosis and meiosis and during which the chromosomes arrive at the poles of the cell and the division of the cytoplasm starts." [GOC:mtg_cell_cycle]


id: GO:0051327
name: meiotic M phase
namespace: biological_process
def:
  "A cell cycle phase during which nuclear division occurs, and which is comprises the phases: prophase, metaphase, anaphase and telophase and occurs as part of a meiotic cell cycle." [GOC:mtg_cell_cycle]


id: GO:0051328
name: meiotic interphase
namespace: biological_process
def:
  "The cell cycle phase which begins after cytokinesis and ends when meiotic prophase begins. Meiotic cells have an interphase after each meiotic division, but only interphase I involves replication of the cell's DNA." [GOC:mtg_cell_cycle]


id: GO:0051329
name: mitotic interphase
namespace: biological_process
def:
  "The cell cycle phase following cytokinesis which begins with G1 phase, proceeds through S phase and G2 phase and ends when mitotic prophase begins. During interphase the cell readies itself for mitosis and the replication of its DNA occurs." [GOC:mtg_cell_cycle]


id: GO:0051330
name: meiotic G1 phase
namespace: biological_process
def:
  "The cell cycle 'gap' phase which is the interval between the completion of DNA segregation by meiosis and the beginning of DNA synthesis." [GOC:mtg_cell_cycle]


id: GO:0051331
name: meiotic G2 phase
namespace: biological_process
def:
  "The cell cycle 'gap' phase which is the interval between the completion of DNA synthesis and the beginning of DNA segregation by meiosis." [GOC:mtg_cell_cycle]


id: GO:0051332
name: meiotic S phase
namespace: biological_process
def:
  "The cell cycle phase, following G1, during which DNA synthesis takes place as part of a meiotic cell cycle." [GOC:mtg_cell_cycle]


id: GO:0051333
name: meiotic nuclear envelope reassembly
namespace: biological_process
def:
  "The cell cycle process in which the reformation of the nuclear envelope during meiosis occurs." [GOC:ai]


id: GO:0051336
name: regulation of hydrolase activity
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of hydrolase activity, the catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [EC:3.-.-.-, GOC:ai]


id: GO:0051337
name: amitosis
namespace: biological_process
def:
  "Nuclear division that occurs by simple constriction of the nucleus without chromosome condensation or spindle formation." [GOC:curators, ISBN:0721662544]


id: GO:0051338
name: regulation of transferase activity
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of transferase activity, the catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [EC:2.-.-.-, GOC:ai]


id: GO:0051339
name: regulation of lyase activity
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of lyase activity, the catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring." [EC:4.-.-.-, GOC:ai]


id: GO:0051340
name: regulation of ligase activity
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of ligase activity, the catalysis of the ligation of two substances with concomitant breaking of a diphosphate linkage, usually in a nucleoside triphosphate. Ligase is the systematic name for any enzyme of EC class 6." [EC:6.-.-.-, GOC:ai]


id: GO:0051341
name: regulation of oxidoreductase activity
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of oxidoreductase activity, the catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [EC:1.-.-.-, GOC:ai]


id: GO:0051342
name: regulation of cyclic-nucleotide phosphodiesterase activity
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of cyclic nucleotide phosphodiesterase activity, the catalysis of the reaction: nucleotide 3',5'-cyclic phosphate + H2O = nucleotide 5'-phosphate." [EC:3.1.4.17, GOC:ai, GOC:tb]


id: GO:0051343
name: positive regulation of cyclic-nucleotide phosphodiesterase activity
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of cyclic nucleotide phosphodiesterase activity, the catalysis of the reaction: nucleotide 3',5'-cyclic phosphate + H2O = nucleotide 5'-phosphate." [GOC:ai, GOC:tb]


id: GO:0051344
name: negative regulation of cyclic-nucleotide phosphodiesterase activity
namespace: biological_process
def:
  "Any process that stops or reduces the rate of cyclic nucleotide phosphodiesterase activity, the catalysis of the reaction: nucleotide 3',5'-cyclic phosphate + H2O = nucleotide 5'-phosphate." [GOC:ai, GOC:tb]


id: GO:0051345
name: positive regulation of hydrolase activity
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of hydrolase activity, the catalysis of the hydrolysis of various bonds." [GOC:ai]


id: GO:0051346
name: negative regulation of hydrolase activity
namespace: biological_process
def:
  "Any process that stops or reduces the rate of hydrolase activity, the catalysis of the hydrolysis of various bonds." [GOC:ai]


id: GO:0051347
name: positive regulation of transferase activity
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of transferase activity, the catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from a donor compound to an acceptor." [GOC:ai]


id: GO:0051348
name: negative regulation of transferase activity
namespace: biological_process
def:
  "Any process that stops or reduces the rate of transferase activity, the catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from a donor compound to an acceptor." [GOC:ai]


id: GO:0051349
name: positive regulation of lyase activity
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of lyase activity, the catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond." [GOC:ai]


id: GO:0051350
name: negative regulation of lyase activity
namespace: biological_process
def:
  "Any process that stops or reduces the rate of lyase activity, the catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond." [GOC:ai]


id: GO:0051351
name: positive regulation of ligase activity
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of ligase activity, the catalysis of the ligation of two substances with concomitant breaking of a diphosphate linkage, usually in a nucleoside triphosphate." [GOC:ai]


id: GO:0051352
name: negative regulation of ligase activity
namespace: biological_process
def:
  "Any process that stops or reduces the rate of ligase activity, the catalysis of the ligation of two substances with concomitant breaking of a diphosphate linkage, usually in a nucleoside triphosphate." [GOC:ai]


id: GO:0051353
name: positive regulation of oxidoreductase activity
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of oxidoreductase activity, the catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered." [GOC:ai]


id: GO:0051354
name: negative regulation of oxidoreductase activity
namespace: biological_process
def:
  "Any process that stops or reduces the rate of oxidoreductase activity, the catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered." [GOC:ai]


id: GO:0051355
name: proprioception involved in equilibrioception
namespace: biological_process
def:
  "The series of events contributing to equilibrioception by which an organism senses the position, location, orientation, and movement of the body and its parts. Proprioception plays an important role in the ability of an organism to perceive its orientation with respect to gravity." [GOC:ai]


id: GO:0051356
name: visual perception involved in equilibrioception
namespace: biological_process
def:
  "The series of events during equilibrioception required for an organism to receive a visual stimulus, convert it to a molecular signal, and recognize and characterize the signal. Visual input plays an important role in the ability of an organism to perceive its orientation with respect to gravity." [GOC:ai]


id: GO:0051357
name: peptide cross-linking via 3-(2-methylthio)ethyl-6-(4-hydroxybenzylidene)-5-iminopiperazin-2-one
namespace: biological_process
def:
  "The formation of a 2-keto-5-iminopiperazine protein chromophore cross-link from the alpha-amino nitrogen of residue n, a methionine, to the alpha-carboxyl carbon of residue n+1, a tyrosine, and a dehydration to form a double bond to the alpha-amino nitrogen of residue n+2. This cross-linking is coupled with a dehydrogenation of residue n+1 to form a double bond between the alpha and beta carbons." [PMID:10852900, PMID:11259412, PMID:15491166, RESID:AA0377]


id: GO:0051358
name: peptide cross-linking via 2-imino-glutamic acid 5-imidazolinone glycine
namespace: biological_process
def:
  "The formation of the non-fluorescent protein chromophore cross-link from the alpha-carboxyl carbon of residue n, a glutamic acid, to the alpha-amino nitrogen of residue n+2, a glycine, and a dehydration to form a double bond to the alpha-amino nitrogen of residue n+1. This cross-linking is coupled with a dehydrogenation of residue n+1 to form a double bond between the alpha and beta carbons. This modification is found in the GFP-like non-fluorescent red chromoprotein from the sea anemone Radianthus macrodactylus." [PMID:11682051, RESID:AA0378]


id: GO:0051359
name: peptide cross-linking via 2-imino-methionine 5-imidazolinone glycine
namespace: biological_process
def:
  "The formation of the fluorescent protein FP611 chromophore cross-link from the alpha-carboxyl carbon of residue n, a methionine, to the alpha-amino nitrogen of residue n+2, a glycine, and a dehydration to form a double bond to the alpha-amino nitrogen of residue n+1. This cross-linking is coupled with a dehydrogenation of residue n+1 to form a double bond between the alpha and beta carbons. This modification is found in the GFP-like fluorescent chromoprotein from the sea anemone Entacmaea quadricolor." [PDB:1UIS, PDB:1XQM, PMID:10852900, PMID:12185250, PMID:12909624, PMID:15542608, RESID:AA0379]


id: GO:0051360
name: peptide cross-linking via L-asparagine 5-imidazolinone glycine
namespace: biological_process
def:
  "The formation of the fluorescent protein FP506 chromophore cross-link from the alpha-carboxyl carbon of residue n, an asparagine, to the alpha-amino nitrogen of residue n+2, a glycine, and a dehydration to form a double bond to the alpha-amino nitrogen of residue n+1. This cross-linking is coupled with a dehydrogenation of residue n+1 to form a double bond between the alpha and beta carbons." [PMID:10504696, RESID:AA0380]


id: GO:0051361
name: peptide cross-linking via L-lysine 5-imidazolinone glycine
namespace: biological_process
def:
  "The formation of a fluorescent protein chromophore cross-link from the alpha-carboxyl carbon of residue n, a lysine, to the alpha-amino nitrogen of residue n+2, a glycine, and a dehydration to form a double bond to the alpha-amino nitrogen of residue n+1. This cross-linking is coupled with a dehydrogenation of residue n+1 to form a double bond between the alpha and beta carbons." [PMID:10504696, RESID:AA0381]


id: GO:0051362
name: peptide cross-linking via 2-tetrahydropyridinyl-5-imidazolinone glycine
namespace: biological_process
def:
  "The formation of a 2-tetrahydropyridinyl-5-imidazolinone protein chromophore cross-link from the alpha-carboxyl carbon of residue n, a lysine, to the alpha-amino nitrogen of residue n+2, a glycine, and a dehydration to form a double bond to the alpha-amino nitrogen of residue n+1. This cross-linking is coupled with a dehydrogenation of residue n+1 to form a double bond between the alpha and beta carbons. In addition, the residue N lysine undergoes cyclization. The alpha-amino nitrogen is replaced by the epsilon-amino nitrogen, the peptide chain is broken, residue N-1 is released as an amide, and a double bond is formed between the alpha-carbon and the nitrogen so that a tetrahydropyridine ring results. This modification is found in the GFP-like fluorescent chromoprotein FP538 from the sea anemone Zoanthus species." [PDB:1XAE, PMID:10504696, PMID:15628861, RESID:AA0382]


