# go

id: GO:0016107
name: sesquiterpenoid catabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the breakdown of sesquiterpenoid compounds, terpenoids with three isoprene units." [GOC:go_curators]


id: GO:0016108
name: tetraterpenoid metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving tetraterpenoid compounds, terpenoids with eight isoprene units." [ISBN:0198547684]


id: GO:0016109
name: tetraterpenoid biosynthetic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of tetraterpenoid compounds, terpenoids with eight isoprene units." [GOC:go_curators]


id: GO:0016110
name: tetraterpenoid catabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the breakdown of tetraterpenoid compounds, terpenoids with eight isoprene units." [GOC:go_curators]


id: GO:0016111
name: polyterpenoid metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving polyterpenoid compounds, terpenoids with more than eight isoprene units." [ISBN:0198547684]


id: GO:0016112
name: polyterpenoid biosynthetic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of polyterpenoid compounds, terpenoids with more than eight isoprene units." [GOC:go_curators]


id: GO:0016113
name: polyterpenoid catabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the breakdown of polyterpenoid compounds, terpenoids with more than eight isoprene units." [GOC:go_curators]


id: GO:0016114
name: terpenoid biosynthetic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of terpenoids, any member of a class of compounds characterized by an isoprenoid chemical structure." [GOC:ai]


id: GO:0016115
name: terpenoid catabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the breakdown of terpenoids, any member of a class of compounds characterized by an isoprenoid chemical structure." [GOC:ai]


id: GO:0016116
name: carotenoid metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving carotenoids, tetraterpenoid compounds in which two units of 4 isoprenoid residues joined head-to-tail are themselves joined tail-to-tail." [ISBN:0198547684]


id: GO:0016117
name: carotenoid biosynthetic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of carotenoids, tetraterpenoid compounds in which two units of 4 isoprenoid residues joined head-to-tail are themselves joined tail-to-tail." [GOC:go_curators]


id: GO:0016118
name: carotenoid catabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the breakdown of carotenoids, tetraterpenoid compounds in which two units of 4 isoprenoid residues joined head-to-tail are themselves joined tail-to-tail." [GOC:go_curators]


id: GO:0016119
name: carotene metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving carotenes, hydrocarbon carotenoids." [ISBN:0198547684]


id: GO:0016120
name: carotene biosynthetic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of carotenes, hydrocarbon carotenoids." [GOC:go_curators]


id: GO:0016121
name: carotene catabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the breakdown of carotenes, hydrocarbon carotenoids." [GOC:go_curators]


id: GO:0016122
name: xanthophyll metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving xanthophylls, oxygen-containing carotenoids." [ISBN:0198547684]


id: GO:0016123
name: xanthophyll biosynthetic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of xanthophylls, oxygen-containing carotenoids." [GOC:go_curators]


id: GO:0016124
name: xanthophyll catabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the breakdown of xanthophylls, oxygen-containing carotenoids." [GOC:go_curators]


id: GO:0016125
name: sterol metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving sterols, steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule." [ISBN:0198547684]


id: GO:0016126
name: sterol biosynthetic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of sterols, steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule." [GOC:go_curators]


id: GO:0016127
name: sterol catabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the breakdown of sterols, steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule." [GOC:go_curators]


id: GO:0016128
name: phytosteroid metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving phytosteroids, steroids of higher plants that differ from animal steroids in having substitutions at C24 and/or a double bond at C22. Phytosteroids are so named because they occur in higher plants; some, notably ergosterol, are also found in fungi." [GOC:mah, ISBN:0198547684]


id: GO:0016129
name: phytosteroid biosynthetic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of phytosteroids, steroids that differ from animal steroids in having substitutions at C24 and/or a double bond at C22. Phytosteroids are so named because they occur in higher plants; some, notably ergosterol, are also found in fungi." [GOC:go_curators, GOC:mah, ISBN:0471331309]


id: GO:0016130
name: phytosteroid catabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the breakdown of phytosteroids, steroids that differ from animal steroids in having substitutions at C24 and/or a double bond at C22. Phytosteroids are so named because they occur in higher plants; some, notably ergosterol, are also found in fungi." [GOC:go_curators, GOC:mah]


id: GO:0016131
name: brassinosteroid metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving brassinosteroids, any of a group of steroid derivatives that occur at very low concentrations in plant tissues and may have hormone-like effects." [ISBN:0192801023]


id: GO:0016132
name: brassinosteroid biosynthetic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of brassinosteroids, any of a group of steroid derivatives that occur at very low concentrations in plant tissues and may have hormone-like effects." [ISBN:0192801023]


id: GO:0016133
name: brassinosteroid catabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the breakdown of brassinosteroids, any of a group of steroid derivatives that occur at very low concentrations in plant tissues and may have hormone-like effects." [ISBN:0192801023]


id: GO:0016134
name: saponin metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving saponins, glycosides of plants in which the aglycan (sapogenin) group is a terpene or steroid and the sugar group is a glucose, a galactose, a pentose, a methylpentose or an oligosaccharide. Saponins are powerful surfactant agents and membrane active; they are, hence, toxic to animals on injection." [ISBN:0198547684]


id: GO:0016135
name: saponin biosynthetic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of saponins, glycosides of plants in which the aglycan (sapogenin) group is a terpene or steroid and the sugar group is a glucose, a galactose, a pentose, a methylpentose or an oligosaccharide. Saponins are powerful surfactant agents and membrane active; they are, hence, toxic to animals on injection." [GOC:go_curators]


id: GO:0016136
name: saponin catabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the breakdown of saponins, glycosides of plants in which the aglycan (sapogenin) group is a terpene or steroid and the sugar group is a glucose, a galactose, a pentose, a methylpentose or an oligosaccharide. Saponins are powerful surfactant agents and membrane active; they are, hence, toxic to animals on injection." [GOC:go_curators]


id: GO:0016137
name: glycoside metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving glycosides, compounds in which a glycosyl group is substituted into a hydroxyl, thiol or selenol group in another compound." [ISBN:0198547684]


id: GO:0016138
name: glycoside biosynthetic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of glycosides, compounds in which a glycosyl group is substituted into a hydroxyl, thiol or selenol group in another compound." [GOC:go_curators]


id: GO:0016139
name: glycoside catabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the breakdown of glycosides, compounds in which a glycosyl group is substituted into a hydroxyl, thiol or selenol group in another compound." [GOC:go_curators]


id: GO:0016143
name: S-glycoside metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving S-glycosides, any compound in which a glycosyl group has been substituted into a thiol group." [ISBN:0198506732]


id: GO:0016144
name: S-glycoside biosynthetic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of S-glycosides, any compound in which a glycosyl group has been substituted into a thiol group." [ISBN:0198506732]


id: GO:0016145
name: S-glycoside catabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the breakdown of S-glycosides, any compound in which a glycosyl group has been substituted into a thiol group." [ISBN:0198506732]


id: GO:0016149
name: translation release factor activity, codon specific
namespace: molecular_function
def:
  "A translation release factor that is specific for one or more particular termination codons; acts at the ribosomal A-site and require polypeptidyl-tRNA at the P-site." [ISBN:0198547684]


id: GO:0016150
name: translation release factor activity, codon nonspecific
namespace: molecular_function
def:
  "A translation release factor that is not specific to particular codons; binds to guanine nucleotides." [ISBN:0198547684]


id: GO:0016153
name: urocanate hydratase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 4-imidazolone-5-propanoate + H(+) = trans-urocanate + H(2)O." [EC:4.2.1.49, RHEA:13104]


id: GO:0016154
name: pyrimidine-nucleoside phosphorylase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: pyrimidine nucleoside + phosphate = pyrimidine + alpha-D-ribose 1-phosphate." [EC:2.4.2.2]


id: GO:0016155
name: formyltetrahydrofolate dehydrogenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 10-formyltetrahydrofolate + H(2)O + NADP(+) = (6S)-5,6,7,8-tetrahydrofolate + CO(2) + H(+) + NADPH." [EC:1.5.1.6, RHEA:10183]


id: GO:0016158
name: 3-phytase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: myo-inositol hexakisphosphate + H2O = D-myo-inositol 1,2,4,5,6-pentakisphosphate + phosphate." [EC:3.1.3.8]


id: GO:0016159
name: muconolactone delta-isomerase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 2,5-dihydro-5-oxofuran-2-acetate = 3,4-dihydro-5-oxofuran-2-acetate." [EC:5.3.3.4]


id: GO:0016161
name: beta-amylase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: (1,4-alpha-D-glucosyl)(n+1) + H2O = (1,4-alpha-D-glucosyl)(n-1) + alpha-maltose. This reaction is the hydrolysis of 1,4-alpha-glucosidic linkages in polysaccharides so as to remove successive maltose units from the non-reducing ends of the chains." [EC:3.2.1.2]


id: GO:0016162
name: cellulose 1,4-beta-cellobiosidase activity
namespace: molecular_function
def:
  "Catalysis of the hydrolysis of (1->4)-beta-D-glucosidic linkages in cellulose and cellotetraose, releasing cellobiose from the non-reducing ends of the chains." [EC:3.2.1.91]


id: GO:0016163
name: nitrogenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 8 reduced ferredoxin + 8 H+ + nitrogen + 16 ATP = 8 oxidized ferredoxin + 2 NH3 + 16 ADP + 16 phosphate." [EC:1.18.6.1]


id: GO:0016165
name: linoleate 13S-lipoxygenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: linoleate + O2 = (9Z,11E)-(13S)-13-hydroperoxyoctadeca-9,11-dienoate." [EC:1.13.11.12, GOC:lb]


id: GO:0016166
name: phytoene dehydrogenase activity
namespace: molecular_function
def:
  "Catalysis of the dehydrogenation of phytoene to produce a carotenoid intermediate such as phytofluene." [http://www.chem.qmul.ac.uk/iubmb/enzyme/reaction/terp/carot.html]


id: GO:0016167
name: glial cell-derived neurotrophic factor receptor activity
namespace: molecular_function
def:
  "Combining with glial cell line-derived neurotrophic factor and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:mah, GOC:signaling]


id: GO:0016168
name: chlorophyll binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with chlorophyll; any compound of magnesium complexed in a porphyrin (tetrapyrrole) ring and which functions as a photosynthetic pigment." [GOC:jl]


id: GO:0016169
name: bacteriochlorophyll c binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with bacteriochlorophyll c, a chlorophyll of photosynthetic bacteria, for example green sulfur bacteria." [ISBN:0192800981]


id: GO:0016172
name: obsolete antifreeze activity
namespace: molecular_function
def:
  "OBSOLETE. Inhibits the formation of ice crystals in organismal fluid (e.g. blood) at below freezing exogenous temperatures." [GOC:jl]


id: GO:0016180
name: snRNA processing
namespace: biological_process
def:
  "Any process involved in the conversion of a primary small nuclear RNA (snRNA) transcript into a mature snRNA molecule." [GOC:jl]


id: GO:0016182
name: synaptic vesicle budding from endosome
namespace: biological_process
def:
  "Budding of synaptic vesicles during the formation of constitutive recycling vesicles from early endosomes." [GOC:curators, PMID:10099709]


id: GO:0016183
name: synaptic vesicle coating
namespace: biological_process
def:
  "The formation of clathrin coated pits in the presynaptic membrane endocytic zone, triggered by the presence of high concentrations of synaptic vesicle components. This process leads to, but does not include budding of the membrane to form new vesicles." [GOC:curators, PMID:10099709, PMID:20448150]


id: GO:0016184
name: obsolete synaptic vesicle retrieval
namespace: biological_process
def:
  "OBSOLETE. Return of a vesicle from the postsynaptic membrane to presynaptic membrane." [GOC:curators]


id: GO:0016185
name: synaptic vesicle budding from presynaptic endocytic zone membrane
namespace: biological_process
def:
  "Evagination of the presynaptic membrane, resulting in the formation of a new synaptic vesicle." [GOC:curators, PMID:10099709, PMID:20448150]


id: GO:0016187
name: obsolete synaptic vesicle internalization
namespace: biological_process
def:
  "OBSOLETE. Internalization of the contents of a synaptic vesicle into the postsynaptic membrane following endocytosis." [GOC:curators]


id: GO:0016188
name: synaptic vesicle maturation
namespace: biological_process
def:
  "Steps required to form an initiated synaptic vesicle into a fully formed and transmissible synaptic vesicle." [GOC:curators, PMID:10099709]


id: GO:0016191
name: synaptic vesicle uncoating
namespace: biological_process
def:
  "The removal of the protein coat on a synaptic vesicle following the pinching step at the end of budding from the presynaptic membrane." [GOC:curators, PMID:10099709, PMID:24596248]


id: GO:0016192
name: vesicle-mediated transport
namespace: biological_process
def:
  "A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000]


id: GO:0016197
name: endosomal transport
namespace: biological_process
def:
  "The directed movement of substances into, out of, or mediated by an endosome, a membrane-bounded organelle that carries materials newly ingested by endocytosis. It passes many of the materials to lysosomes for degradation." [ISBN:0198506732]


id: GO:0016198
name: axon choice point recognition
namespace: biological_process
def:
  "The recognition of molecules at a choice point by an axon growth cone; at a choice point the growth cone determines the direction of its future growth." [PMID:10218152]


id: GO:0016199
name: axon midline choice point recognition
namespace: biological_process
def:
  "The recognition of molecules at the central nervous system midline choice point by an axon growth cone; this choice point determines whether the growth cone will cross the midline." [PMID:11376484]


id: GO:0016200
name: synaptic target attraction
namespace: biological_process
def:
  "The process in which a neuronal cell in a multicellular organism recognizes chemoattractant signals from, and grows towards, potential targets." [GOC:mah, ISBN:0878932437]


id: GO:0016201
name: synaptic target inhibition
namespace: biological_process
def:
  "The process in which a neuronal cell in a multicellular organism recognizes chemorepellent signals that inhibit its growth toward the source." [GOC:mah, ISBN:0878932437]


id: GO:0016202
name: regulation of striated muscle tissue development
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of striated muscle development." [GOC:go_curators]


id: GO:0016203
name: muscle attachment
namespace: biological_process
def:
  "The developmental process in which a skeletal muscle attaches to its target (such as bone or body wall)." [GOC:isa_complete, GOC:sart]


id: GO:0016204
name: determination of muscle attachment site
namespace: biological_process
def:
  "The process that mediates the transfer of information from the cells of a muscle to those of its intended target, thereby identifying the target site." [GOC:isa_complete]


id: GO:0016205
name: selenocysteine methyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: selenocysteine + S-adenosyl-L-methionine = Se-methylselenocysteine + S-adenosyl-homocysteine." [EC:2.1.1.-, PMID:10026151]


id: GO:0016206
name: catechol O-methyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: S-adenosyl-L-methionine + a catechol = S-adenosyl-L-homocysteine + a guaiacol." [EC:2.1.1.6]


id: GO:0016207
name: 4-coumarate-CoA ligase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: ATP + 4-coumarate + CoA = AMP + diphosphate + 4-coumaroyl-CoA." [EC:6.2.1.12]


id: GO:0016209
name: antioxidant activity
namespace: molecular_function
def:
  "Inhibition of the reactions brought about by dioxygen (O2) or peroxides. Usually the antioxidant is effective because it can itself be more easily oxidized than the substance protected. The term is often applied to components that can trap free radicals, thereby breaking the chain reaction that normally leads to extensive biological damage." [ISBN:0198506732]


id: GO:0016210
name: naringenin-chalcone synthase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 3 malonyl-CoA + 4-coumaroyl-CoA = 4 CoA + naringenin chalcone + 3 CO2." [EC:2.3.1.74]


id: GO:0016211
name: ammonia ligase activity
namespace: molecular_function
def:
  "Catalysis of the ligation of ammonia (NH3) to another substance via a carbon-nitrogen bond with concomitant breakage of a diphosphate linkage, usually in a nucleoside triphosphate." [GOC:jl]


id: GO:0016212
name: kynurenine-oxoglutarate transaminase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: L-kynurenine + 2-oxoglutarate = 4-(2-aminophenyl)-2,4-dioxobutanoate + L-glutamate." [EC:2.6.1.7]


id: GO:0016213
name: linoleoyl-CoA desaturase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: linoleoyl-CoA + reduced acceptor + O2 = gamma-linolenoyl-CoA + acceptor + 2 H2O." [EC:1.14.19.3]


id: GO:0016215
name: acyl-CoA desaturase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: acyl-CoA + reduced acceptor + O2 = desaturated-acyl-CoA + acceptor + 2 H2O." [EC:1.14.19.1, EC:1.14.19.5, GOC:mah]


id: GO:0016216
name: isopenicillin-N synthase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: N-[(5S)-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine + O(2) = 2 H(2)O + isopenicillin N." [EC:1.21.3.1, RHEA:22431]


id: GO:0016217
name: N-ethylammeline chlorohydrolase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: deethylsimazine + H2O = N-ethylammeline + chloride + H+." [MetaCyc:R465-RXN]


id: GO:0016222
name: procollagen-proline 4-dioxygenase complex
namespace: cellular_component
def:
  "A protein complex that catalyzes the formation of procollagen trans-4-hydroxy-L-proline and succinate from procollagen L-proline and 2-oxoglutarate, requiring Fe2+ and ascorbate. Contains two alpha subunits that contribute to most parts of the catalytic sites, and two beta subunits that are identical to protein-disulfide isomerase." [PMID:14500733, PMID:7753822]


id: GO:0016226
name: iron-sulfur cluster assembly
namespace: biological_process
def:
  "The incorporation of iron and exogenous sulfur into a metallo-sulfur cluster." [GOC:jl, GOC:mah, GOC:pde, GOC:vw]


id: GO:0016227
name: obsolete tRNA sulfurtransferase activity
namespace: molecular_function
def:
  "OBSOLETE. Catalysis of the reaction: L-cysteine + 'activated' tRNA = L-serine + tRNA containing a thionucleotide." [EC:2.8.1.4]


id: GO:0016229
name: steroid dehydrogenase activity
namespace: molecular_function
def:
  "Catalysis of an oxidation-reduction (redox) reaction in which one substrate is a sterol derivative." [GOC:mah]


id: GO:0016231
name: beta-N-acetylglucosaminidase activity
namespace: molecular_function
def:
  "Catalysis of the hydrolysis of terminal non-reducing N-acetyl-D-glucosamine residues in N-acetyl-beta-D-glucosaminides." [EC:3.2.1.52, MetaCyc:3.2.1.52-RXN]


id: GO:0016232
name: HNK-1 sulfotransferase activity
namespace: molecular_function
def:
  "Catalysis of the synthesis of the HKK-1 carbohydrate epitope; adds a sulfate group to a precursor, GlcA-beta-(1->3)-Gal-beta-(1->4)-GlcNAc-beta-(1->R), forming sulfo-3GlcA-beta-(1->3)-Gal-beta-(1->4)-GlcNAc-beta-(1->R)." [PMID:9478973]


id: GO:0016233
name: telomere capping
namespace: biological_process
def:
  "A process in which telomeres are protected from degradation and fusion, thereby ensuring chromosome stability by protecting the ends from both degradation and from being recognized as damaged DNA. May be mediated by specific single- or double-stranded telomeric DNA binding proteins." [GOC:mah, GOC:rn, PMID:11349150, PMID:11352055]


id: GO:0016234
name: inclusion body
namespace: cellular_component
def:
  "A discrete intracellular part formed of aggregated molecules such as proteins or other biopolymers." [GOC:mah, PMID:11121744]


id: GO:0016235
name: aggresome
namespace: cellular_component
def:
  "An inclusion body formed by dynein-dependent retrograde transport of an aggregated protein on microtubules." [PMID:11121744]


id: GO:0016236
name: macroautophagy
namespace: biological_process
def:
  "The major inducible pathway for the general turnover of cytoplasmic constituents in eukaryotic cells, it is also responsible for the degradation of active cytoplasmic enzymes and organelles during nutrient starvation. Macroautophagy involves the formation of double-membrane-bounded autophagosomes which enclose the cytoplasmic constituent targeted for degradation in a membrane-bounded structure.  Autophagosomes then fuse with a lysosome (or vacuole) releasing single-membrane-bounded autophagic bodies that are then degraded within the lysosome (or vacuole). Though once thought to be a purely non-selective process, it appears that some types of macroautophagy, e.g. macropexophagy, macromitophagy, may involve selective targeting of the targets to be degraded." [PMID:11099404, PMID:12914914, PMID:15798367, PMID:16973210, PMID:20159618, PMID:9412464]


id: GO:0016237
name: lysosomal microautophagy
namespace: biological_process
def:
  "The transfer of cytosolic components into the lysosomal compartment by direct invagination of the lysosomal membrane without prior sequestration into an autophagosome. The engulfing membranes fuse, resulting in the lysosomal delivery of the cargo wrapped in a single membrane derived from the invaginated lysosomal membrane. In S. cerevisiae, the vacuole is the lysosomal compartment." [PMID:14679207, PMID:15798367, PMID:16973210, PMID:9566964]


id: GO:0016239
name: positive regulation of macroautophagy
namespace: biological_process
def:
  "Any process, such as recognition of nutrient depletion, that activates or increases the rate of macroautophagy to bring cytosolic macromolecules to the vacuole/lysosome for degradation." [GOC:go_curators, PMID:9412464]


id: GO:0016240
name: autophagosome docking
namespace: biological_process
def:
  "The initial attachment of an autophagosome membrane to the target membrane, mediated by proteins protruding from the membrane of the vesicle and the target membrane. Docking requires only that the two membranes come close enough for these proteins to interact and adhere." [GOC:autophagy, GOC:mah]


id: GO:0016242
name: negative regulation of macroautophagy
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of macroautophagy." [GOC:go_curators]


id: GO:0016246
name: RNA interference
namespace: biological_process
def:
  "The process in which double-stranded RNAs silence cognate genes. Involves posttranscriptional gene inactivation ('silencing') both of transgenes or dsRNA introduced into a germline, and of the host gene(s) homologous to the transgenes or dsRNA. This silencing is triggered by the introduction of transgenes or double-stranded RNA (dsRNA), and can occur through a specific decrease in the level of mRNA, or by negative regulation of translation, of both host genes and transgenes." [GOC:ems, PMID:11201747, PMID:11713190, PMID:18771919]


id: GO:0016247
name: channel regulator activity
namespace: molecular_function
def:
  "Modulates the activity of a channel. A channel catalyzes energy-independent facilitated diffusion, mediated by passage of a solute through a transmembrane aqueous pore or channel." [GOC:mah]


id: GO:0016248
name: channel inhibitor activity
namespace: molecular_function
def:
  "Stops, prevents, or reduces the activity of a channel. A channel catalyzes energy-independent facilitated diffusion, mediated by passage of a solute through a transmembrane aqueous pore or channel." [GOC:mah]


id: GO:0016251
name: obsolete general RNA polymerase II transcription factor activity
namespace: molecular_function
def:
  "OBSOLETE. Any function that supports basal (unregulated) transcription of genes by core RNA polymerase II. Five general transcription factors are necessary and sufficient for such basal transcription in yeast: TFIIB, TFIID, TFIIE, TFIIF, TFIIH and TATA-binding protein (TBF)." [PMID:10384286, PMID:9774831]


id: GO:0016252
name: obsolete nonspecific RNA polymerase II transcription factor activity
namespace: molecular_function
def:
  "OBSOLETE. Any function that supports transcription of genes by RNA polymerase II, and is not specific to a particular gene or gene set." [GOC:jl]


id: GO:0016254
name: preassembly of GPI anchor in ER membrane
namespace: biological_process
def:
  "The stepwise addition of the components of the GPI anchor on to phosphatidylinositol lipids in the endoplasmic reticulum membrane." [ISBN:0879695595]


id: GO:0016255
name: attachment of GPI anchor to protein
namespace: biological_process
def:
  "A transamidation reaction that results in the cleavage of the polypeptide chain and the concomitant transfer of the GPI anchor to the newly formed carboxy-terminal amino acid of the anchored protein. The cleaved C-terminal contains the C-terminal GPI signal sequence of the newly synthesized polypeptide chain." [ISBN:0879695595]


id: GO:0016256
name: N-glycan processing to lysosome
namespace: biological_process
def:
  "The modification of high-mannose N-glycans by UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase and the subsequent removal of the N-acetylglucosamine residues yielding mannose-6-P that occurs in the ER-Golgi apparatus to N-glycans destined for the lysosome." [ISBN:0879695595]


id: GO:0016257
name: N-glycan processing to secreted and cell-surface N-glycans
namespace: biological_process
def:
  "The modification of high-mannose (Man9-Asn) N-glycans by mannosyl-oligosaccharide 1,2-alpha-mannosidase. This may result in Man8GlcNAc2-Asn N-glycans (which in yeast may be subsequently modified by the addition of further mannose residues) or Man5GlcNAc2-Asn N-glycans that are substrates for further diversification in the Golgi apparatus." [ISBN:0879695595]


id: GO:0016258
name: N-glycan diversification
namespace: biological_process
def:
  "The generation, in the Golgi apparatus, of side chain diversity from high mannose Man5GlcNAc2-Asn N-glycans by specific glycosyltransferases and glycosidases." [ISBN:0879695595]


id: GO:0016259
name: selenocysteine metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving selenocysteine, an essential component of glutathione peroxidase and some other proteins." [GOC:go_curators, ISBN:0198506732]


id: GO:0016260
name: selenocysteine biosynthetic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of selenocysteine, an essential component of glutathione peroxidase and some other proteins." [GOC:go_curators, ISBN:0198506732]


id: GO:0016261
name: selenocysteine catabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the breakdown of selenocysteine, an essential component of glutathione peroxidase and some other proteins." [GOC:go_curators, ISBN:0198506732]


id: GO:0016262
name: protein N-acetylglucosaminyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + protein = UDP + 4-N-(N-acetyl-D-glucosaminyl)-protein." [EC:2.4.1.94]


id: GO:0016263
name: glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the addition of a galactosyl residue to a non-reducing O-linked N-acetylgalactosamine residue in an O-glycan." [EC:2.4.1.122, GOC:ma]


id: GO:0016264
name: gap junction assembly
namespace: biological_process
def:
  "Assembly of gap junctions, which are found in most animal tissues, and serve as direct connections between the cytoplasms of adjacent cells. They provide open channels through the plasma membrane, allowing ions and small molecules (less than approximately a thousand daltons) to diffuse freely between neighboring cells, but preventing the passage of proteins and nucleic acids." [GOC:jid, ISBN:0716731363]


id: GO:0016265
name: death
namespace: biological_process
def:
  "A permanent cessation of all vital functions: the end of life; can be applied to a whole organism or to a part of an organism." [GOC:mah, GOC:mtg_apoptosis, ISBN:0877797099]


id: GO:0016266
name: O-glycan processing
namespace: biological_process
def:
  "The stepwise addition of carbohydrate or carbohydrate derivative residues to the initially added O-linked residue (usually GalNAc) to form a core O-glycan structure." [GOC:mah, GOC:pr, PMID:10580130]


id: GO:0016267
name: O-glycan processing, core 1
namespace: biological_process
def:
  "The stepwise addition of carbohydrate or carbohydrate derivative residues to the initially added O-linked residue (usually GalNAc) to form the core 1 O-glycan structure, Gal-beta-(1->3)-GalNAc." [GOC:mah, GOC:pr, PMID:10580130]


id: GO:0016268
name: O-glycan processing, core 2
namespace: biological_process
def:
  "The stepwise addition of carbohydrate or carbohydrate derivative residues to the initially added O-linked residue (usually GalNAc) to form the core 2 O-glycan structure, GlcNAc-beta-(1->6)[Gal-beta-(1->3)]-GalNAc." [GOC:mah, GOC:pr, PMID:10580130]


id: GO:0016269
name: O-glycan processing, core 3
namespace: biological_process
def:
  "The stepwise addition of carbohydrate or carbohydrate derivative residues to the initially added O-linked residue (usually GalNAc) to form the core 3 O-glycan structure, GlcNAc-beta-(1->3)-GalNAc." [GOC:mah, GOC:pr, PMID:10580130]


id: GO:0016270
name: O-glycan processing, core 4
namespace: biological_process
def:
  "The stepwise addition of carbohydrate or carbohydrate derivative residues to the initially added O-linked residue (usually GalNAc) to form the core 4 O-glycan structure, GlcNAc-beta-(1->6)[GalNAc-beta-(1->3)]-GalNAc." [GOC:mah, GOC:pr, PMID:10580130]


id: GO:0016272
name: prefoldin complex
namespace: cellular_component
def:
  "A multisubunit chaperone that is capable of delivering unfolded proteins to cytosolic chaperonin, which it acts as a cofactor for. In humans, the complex is a heterohexamer of two PFD-alpha and four PFD-beta type subunits. In Saccharomyces cerevisiae, it also acts in the nucleus to regulate the rate of elongation by RNA polymerase II via a direct effect on histone dynamics." [GOC:jl, PMID:17384227, PMID:24068951, PMID:9630229]


id: GO:0016273
name: arginine N-methyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to an amino group of an arginine residue." [GOC:mah]


id: GO:0016274
name: protein-arginine N-methyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: S-adenosyl-L-methionine + (protein)-arginine = S-adenosyl-L-homocysteine + (protein)-N-methyl-arginine." [EC:2.1.1.125, EC:2.1.1.126, GOC:mah, PMID:12351636]


id: GO:0016275
name: [cytochrome c]-arginine N-methyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: S-adenosyl-L-methionine + (cytochrome c)-arginine = S-adenosyl-L-homocysteine + (cytochrome c)-N(omega)-methyl-arginine." [EC:2.1.1.124, GOC:ma]


id: GO:0016277
name: [myelin basic protein]-arginine N-methyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: S-adenosyl-L-methionine + (myelin basic protein)-arginine = S-adenosyl-L-homocysteine + (myelin basic protein)-N(omega)-methyl-arginine." [EC:2.1.1.126]


id: GO:0016278
name: lysine N-methyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to the epsilon-amino group of a lysine residue." [GOC:mah]


id: GO:0016279
name: protein-lysine N-methyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to the epsilon-amino group of a lysine residue in a protein substrate." [PMID:12054878]


id: GO:0016281
name: eukaryotic translation initiation factor 4F complex
namespace: cellular_component
def:
  "The eukaryotic translation initiation factor 4F complex is composed of eIF4E, eIF4A and eIF4G; it is involved in the recognition of the mRNA cap, ATP-dependent unwinding of the 5'-terminal secondary structure and recruitment of the mRNA to the ribosome." [GOC:hb, PMID:8449919]


id: GO:0016282
name: eukaryotic 43S preinitiation complex
namespace: cellular_component
def:
  "A protein complex composed of the 40S ribosomal subunit plus eIF1A, eIF3, and eIF2-GTP-bound methionyl-initiator methionine tRNA." [GOC:hjd, PMID:15145049]


id: GO:0016284
name: obsolete alanine aminopeptidase activity
namespace: molecular_function
def:
  "OBSOLETE. Catalysis of the release of an N-terminal amino acid, preferentially alanine, from an oligopeptide or polypeptide." [GOC:jl]


id: GO:0016285
name: obsolete cytosol alanyl aminopeptidase activity
namespace: molecular_function
def:
  "OBSOLETE. Catalysis of the release of an N-terminal amino acid, preferentially alanine, from a wide range of peptides, amides and arylamides." [EC:3.4.11.14]


id: GO:0016286
name: small conductance calcium-activated potassium channel activity
namespace: molecular_function
def:
  "Enables the transmembrane transfer of potassium by a channel with a unit conductance of 2 to 20 picoSiemens that opens in response to stimulus by internal calcium ions. Small conductance calcium-activated potassium channels are more sensitive to calcium than are large conductance calcium-activated potassium channels. Transport by a channel involves catalysis of facilitated diffusion of a solute (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel, without evidence for a carrier-mediated mechanism." [GOC:mtg_transport, OMIM:602754]


id: GO:0016287
name: glycerone-phosphate O-acyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: acyl-CoA + glycerone phosphate = 1-acylglycerone 3-phosphate + CoA." [EC:2.3.1.42, RHEA:17660]


id: GO:0016295
name: myristoyl-[acyl-carrier-protein] hydrolase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: myristoyl-[acyl-carrier protein] + H2O = [acyl-carrier protein] + myristate." [EC:3.1.2.14, MetaCyc:RXN-10727]


id: GO:0016296
name: palmitoyl-[acyl-carrier-protein] hydrolase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: palmitoyl-[acyl-carrier protein] + H2O = [acyl-carrier protein] + palmitate." [EC:3.1.2.14, MetaCyc:RXN-9549]


id: GO:0016297
name: acyl-[acyl-carrier-protein] hydrolase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: acyl-[acyl-carrier protein] + H2O = [acyl-carrier protein] + a fatty acid." [EC:3.1.2.14, MetaCyc:RXN-7902]


id: GO:0016299
name: obsolete regulator of G-protein signaling activity
namespace: molecular_function
def:
  "OBSOLETE. Inhibits signal transduction the GTPase activity of G-protein alpha subunits, thereby driving them into their inactive GDP-bound form." [GOC:curators]


id: GO:0016300
name: tRNA (uracil) methyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the transfer of a methyl group from a donor to a uracil residue in a tRNA molecule." [GOC:mah]


id: GO:0016301
name: kinase activity
namespace: molecular_function
def:
  "Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732]


id: GO:0016303
name: 1-phosphatidylinositol-3-kinase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol + ATP = a 1-phosphatidyl-1D-myo-inositol 3-phosphate + ADP + 2 H(+)." [EC:2.7.1.137, RHEA:12712]


id: GO:0016304
name: obsolete phosphatidylinositol 3-kinase activity, class I
namespace: molecular_function
def:
  "OBSOLETE. A heterodimeric phosphoinositide 3-kinase which can phosphorylate phosphatidylinositol, phosphatidylinositol-4-phosphate or phosphatidylinositol-4,5-bisphosphate. Also possesses intrinsic protein kinase activity." [PMID:9759495]


id: GO:0016305
name: obsolete phosphatidylinositol 3-kinase activity, class II
namespace: molecular_function
def:
  "OBSOLETE. A phosphoinositide 3-kinase which can phosphorylate phosphatidylinositol and phosphatidylinositol-4-phosphate; the human form can phosphorylate phosphatidylinositol-4,5-bisphosphate in the presence of phosphatidylserine." [PMID:9759495]


id: GO:0016306
name: obsolete phosphatidylinositol 3-kinase activity, class III
namespace: molecular_function
def:
  "OBSOLETE. A phosphoinositide 3-kinase which can only phosphorylate phosphatidylinositol." [PMID:9759495]


id: GO:0016307
name: phosphatidylinositol phosphate kinase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: ATP + a phosphatidylinositol phosphate = ADP + a phosphatidylinositol bisphosphate." [EC:2.7.1.-, PMID:9759495]


id: GO:0016308
name: 1-phosphatidylinositol-4-phosphate 5-kinase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4-phosphate + ATP = 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + ADP + 2 H(+)." [EC:2.7.1.68, RHEA:14428]


id: GO:0016309
name: 1-phosphatidylinositol-5-phosphate 4-kinase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: ATP + 1-phosphatidyl-1D-myo-inositol 5-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate." [EC:2.7.1.149]


id: GO:0016310
name: phosphorylation
namespace: biological_process
def:
  "The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide." [ISBN:0198506732]


id: GO:0016311
name: dephosphorylation
namespace: biological_process
def:
  "The process of removing one or more phosphoric (ester or anhydride) residues from a molecule." [ISBN:0198506732]


id: GO:0016312
name: inositol bisphosphate phosphatase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: myo-inositol bisphosphate + H2O = myo-inositol phosphate + phosphate." [GOC:hb]


id: GO:0016313
name: obsolete inositol-1,4,5-trisphosphate phosphatase
namespace: molecular_function
def:
  "OBSOLETE. The removal of one of the phosphate groups from an inositol triphosphate to produce an inositol bisphosphate." [GOC:hb]


id: GO:0016314
name: phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: phosphatidylinositol-3,4,5-trisphosphate + H2O = phosphatidylinositol-4,5-bisphosphate + phosphate." [EC:3.1.3.67]


id: GO:0016316
name: phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 1-phosphatidyl-myo-inositol 3,4-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 3-phosphate + phosphate." [EC:3.1.3.66, GOC:hb]


id: GO:0016318
name: ommatidial rotation
namespace: biological_process
def:
  "The process in which photoreceptors are arranged in ommatidia in the dorsal and ventral fields to be mirror images. The polarity is established in the imaginal discs concurrently with cell fate specification." [PMID:10725247]


id: GO:0016319
name: mushroom body development
namespace: biological_process
def:
  "The process whose specific outcome is the progression of the mushroom body over time, from its formation to the mature structure. The mushroom body is composed of the prominent neuropil structures of the insect central brain, thought to be crucial for olfactory associated learning. These consist mainly of a bulbous calyx and tightly packaged arrays of thin parallel fibers of the Kenyon cells." [PMID:8790424]


id: GO:0016320
name: endoplasmic reticulum membrane fusion
namespace: biological_process
def:
  "The joining of 2 or more lipid bilayer membranes that surround the endoplasmic reticulum." [GOC:elh, GOC:jid]


id: GO:0016321
name: female meiosis chromosome segregation
namespace: biological_process
def:
  "The cell cycle process in which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets during the meiotic cell cycle in a female." [GOC:ai]


id: GO:0016322
name: neuron remodeling
namespace: biological_process
def:
  "The developmentally regulated remodeling of neuronal projections such as pruning to eliminate the extra dendrites and axons projections set up in early stages of nervous system development." [GOC:hb]


id: GO:0016323
name: basolateral plasma membrane
namespace: cellular_component
def:
  "The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis." [GOC:go_curators]


id: GO:0016325
name: oocyte microtubule cytoskeleton organization
namespace: biological_process
def:
  "Formation and maintenance of a polarized microtubule array originating from a microtubule-organizing center (MTOC) in the oocyte. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:11231123]


id: GO:0016326
name: obsolete kinesin motor activity
namespace: molecular_function
def:
  "OBSOLETE. The hydrolysis of ATP (and GTP) that drives the microtubular motor along microtubules." [GOC:hb]


id: GO:0016328
name: lateral plasma membrane
namespace: cellular_component
def:
  "The portion of the plasma membrane at the lateral side of the cell. In epithelial cells, lateral plasma membranes are on the sides of cells which lie at the interface of adjacent cells." [GOC:hb, GOC:mah, GOC:pr]


id: GO:0016329
name: obsolete apoptosis regulator activity
namespace: molecular_function
def:
  "OBSOLETE. The function held by products which directly regulate any step in the process of apoptosis." [GOC:jl]


id: GO:0016330
name: second mitotic wave involved in compound eye morphogenesis
namespace: biological_process
def:
  "A discrete cell cycle in the third instar eye imaginal disc after progression of the morphogenetic furrow that contributes to compound eye morphogenesis. It is essential for generation of a sufficient pool of uncommitted cells to develop complete ommatidia." [PMID:11257224]


id: GO:0016331
name: morphogenesis of embryonic epithelium
namespace: biological_process
def:
  "The process in which the anatomical structures of embryonic epithelia are generated and organized." [GOC:jl]


id: GO:0016332
name: establishment or maintenance of polarity of embryonic epithelium
namespace: biological_process
def:
  "Any cellular process that results in the specification, formation or maintenance of anisotropic intracellular organization of epithelial cells in an embryo." [GOC:isa_complete, GOC:mah]


id: GO:0016333
name: morphogenesis of follicular epithelium
namespace: biological_process
def:
  "The process in which the anatomical structures of a follicular epithelium are generated and organized." [GOC:jl]


id: GO:0016334
name: establishment or maintenance of polarity of follicular epithelium
namespace: biological_process
def:
  "Any cellular process that results in the specification, formation or maintenance of a polarized follicular epithelial sheet." [GOC:bf, GOC:mah]


id: GO:0016335
name: morphogenesis of larval imaginal disc epithelium
namespace: biological_process
def:
  "The process in which the anatomical structures of a larval imaginal disc epithelium are generated and organized." [GOC:jl]


id: GO:0016336
name: establishment or maintenance of polarity of larval imaginal disc epithelium
namespace: biological_process
def:
  "Any cellular process that results in the specification, formation or maintenance of a polarized larval imaginal disc epithelium." [GOC:jl, GOC:mah]


id: GO:0016337
name: single organismal cell-cell adhesion
namespace: biological_process
def:
  "The attachment of one cell to another cell via adhesion molecules, where both cells are part of the same organism." [GOC:hb]


id: GO:0016338
name: calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules
namespace: biological_process
def:
  "The attachment of one cell to another cell via adhesion molecules that do not require the presence of calcium for the interaction." [GOC:hb]


id: GO:0016339
name: calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules
namespace: biological_process
def:
  "The attachment of one cell to another cell via adhesion molecules that require the presence of calcium for the interaction." [GOC:hb]


id: GO:0016340
name: calcium-dependent cell-matrix adhesion
namespace: biological_process
def:
  "The binding of a cell to the extracellular matrix via adhesion molecules that require the presence of calcium for the interaction." [GOC:hb]


id: GO:0016342
name: catenin complex
namespace: cellular_component
def:
  "Complex of peripheral cytoplasmic proteins (alpha-, beta- and gamma-catenin) that interact with the cytoplasmic region of uvomorulin/E-cadherin to connect it to the actin cytoskeleton." [ISBN:0198599323]


id: GO:0016343
name: obsolete cytoskeletal anchoring activity
namespace: molecular_function
def:
  "OBSOLETE. The direct or indirect linkage of cytoskeletal filaments to the plasma membrane." [ISBN:0198599323]


id: GO:0016344
name: meiotic chromosome movement towards spindle pole
namespace: biological_process
def:
  "The cell cycle process in which the directed movement of chromosomes from the center of the spindle towards the spindle poles takes place, mediated by the shortening of microtubules attached to the chromosomes. This occurs during meiosis." [GOC:ai]


id: GO:0016345
name: female meiotic chromosome movement towards spindle pole
namespace: biological_process
def:
  "The directed movement of chromosomes in the center of the spindle towards the spindle poles, mediated by the shortening of microtubules attached to the chromosomes, during female meiosis." [GOC:ai]


id: GO:0016346
name: male meiotic chromosome movement towards spindle pole
namespace: biological_process
def:
  "The directed movement of chromosomes in the center of the spindle towards the spindle poles, mediated by the shortening of microtubules attached to the chromosomes, during male meiosis." [GOC:ai]


id: GO:0016348
name: imaginal disc-derived leg joint morphogenesis
namespace: biological_process
def:
  "The process in which the anatomical structures of an imaginal disc-derived leg joint are generated and organized. The leg joint is a flexible region that separates the rigid sections of a leg to allow movement in a controlled manner. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238]


id: GO:0016358
name: dendrite development
namespace: biological_process
def:
  "The process whose specific outcome is the progression of the dendrite over time, from its formation to the mature structure. A dendrite is a freely branching protoplasmic process of a nerve cell." [GOC:jl, ISBN:0198506732]


id: GO:0016360
name: sensory organ precursor cell fate determination
namespace: biological_process
def:
  "The process in which a cell becomes capable of differentiating autonomously into a sensory organ precursor cell regardless of its environment; upon determination, the cell fate cannot be reversed." [GOC:go_curators]


id: GO:0016361
name: activin receptor activity, type I
namespace: molecular_function
def:
  "Combining with activin-bound type II activin receptor to initiate a change in cell activity; upon binding, acts as a downstream transducer of activin signals." [GOC:mah, PMID:8622651]


id: GO:0016362
name: activin receptor activity, type II
namespace: molecular_function
def:
  "Combining with activin to initiate a change in cell activity; upon ligand binding, binds to and catalyses the phosphorylation of a type I activin receptor." [GOC:mah, PMID:8622651]


id: GO:0016401
name: palmitoyl-CoA oxidase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: palmitoyl-CoA + O2 = trans-2,3-dehydropalmitoyl-CoA + hydrogen peroxide." [GOC:jsg]


id: GO:0016402
name: pristanoyl-CoA oxidase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: pristanoyl-CoA + O2 = trans-2,3-dehydropristanoyl-CoA + hydrogen peroxide." [GOC:jsg]


id: GO:0016403
name: dimethylargininase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: N(G),N(G)-dimethyl-L-arginine + H2O = dimethylamine + L-citrulline." [EC:3.5.3.18]


id: GO:0016404
name: 15-hydroxyprostaglandin dehydrogenase (NAD+) activity
namespace: molecular_function
def:
  "Catalysis of the reaction: (5Z,13E)-(15S)-11-alpha,15-dihydroxy-9-oxoprost-13-enoate + NAD+ = (5Z,13E)-11-alpha-hydroxy-9,15-dioxoprost-13-enoate + NADH + H+." [EC:1.1.1.141]


id: GO:0016409
name: palmitoyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the transfer of a palmitoyl (CH3-[CH2]14-CO-) group to an acceptor molecule." [GOC:ai]


id: GO:0016411
name: acylglycerol O-acyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the transfer of an acyl group to an oxygen atom on the acylglycerol molecule." [GOC:ai]


id: GO:0016414
name: O-octanoyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the transfer of an octanoyl group to an oxygen atom on the acceptor molecule." [GOC:ai]


id: GO:0016416
name: O-palmitoyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the transfer of a palmitoyl group to an oxygen atom on the acceptor molecule." [GOC:ai]


id: GO:0016421
name: CoA carboxylase activity
namespace: molecular_function
def:
  "Catalysis of the joining of a carboxyl group to a molecule that is attached to CoA, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [GOC:mah]


id: GO:0016422
name: mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: S-adenosyl-L-methionine + m(7)G(5')pppAm = S-adenosyl-L-homocysteine + m(7)G(5')pppm(6)Am." [EC:2.1.1.62]


id: GO:0016423
name: tRNA (guanine) methyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing methylguanine." [EC:2.1.1.-]


id: GO:0016426
name: tRNA (adenine) methyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing methyladenine." [EC:2.1.1.-]


id: GO:0016427
name: tRNA (cytosine) methyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing methylcytosine." [EC:2.1.1.-]


id: GO:0016428
name: tRNA (cytosine-5-)-methyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing 5-methylcytosine." [EC:2.1.1.29]


id: GO:0016429
name: tRNA (adenine-N1-)-methyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing N1-methyladenine." [EC:2.1.1.36]


id: GO:0016430
name: tRNA (adenine-N6-)-methyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing N6-methyladenine." [EC:2.1.1.55]


id: GO:0016432
name: tRNA-uridine aminocarboxypropyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: S-adenosyl-L-methionine + tRNA uridine = 5'-methylthioadenosine + tRNA 3-(3-amino-3-carboxypropyl)-uridine." [EC:2.5.1.25]


id: GO:0016433
name: rRNA (adenine) methyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing methyladenine." [EC:2.1.1.-]


id: GO:0016434
name: rRNA (cytosine) methyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing methylcytosine." [EC:2.1.1.-]


id: GO:0016435
name: rRNA (guanine) methyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing methylguanine." [EC:2.1.1.-]


id: GO:0016436
name: rRNA (uridine) methyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing methyluridine." [EC:2.1.1.-]


id: GO:0016438
name: tRNA-queuosine beta-mannosyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: GDP-mannose + tRNA(Asp)-queuosine = GDP + tRNA(Asp)-O-5''-beta-D-mannosylqueuosine." [EC:2.4.1.110]


id: GO:0016442
name: RISC complex
namespace: cellular_component
def:
  "A ribonucleoprotein complex that contains members of the Argonaute family of proteins, small interfering RNAs (siRNAs) or microRNAs (miRNAs), and miRNA or siRNA-complementary mRNAs, in addition to a number of accessory factors. The RISC complex is involved in posttranscriptional repression of gene expression through downregulation of translation or induction of mRNA degradation." [PMID:10749213, PMID:15145345]


id: GO:0016443
name: bidentate ribonuclease III activity
namespace: molecular_function
def:
  "Catalysis of the digestion of double-stranded RNAs into 20 to 30-nucleotide products. These products typically associate to the RNA-induced silencing complex and serve as guide RNAs for posttranslational RNA interference." [PMID:15242644]


id: GO:0016445
name: somatic diversification of immunoglobulins
namespace: biological_process
def:
  "The somatic process that results in the generation of sequence diversity of immunoglobulins." [GOC:add, GOC:ma, ISBN:0781735149]


id: GO:0016446
name: somatic hypermutation of immunoglobulin genes
namespace: biological_process
def:
  "Mutations occurring somatically that result in amino acid changes in the rearranged V regions of immunoglobulins." [GOC:add, ISBN:0781735149, PMID:11205330, PMID:11205333, PMID:14975236, PMID:7813007]


id: GO:0016447
name: somatic recombination of immunoglobulin gene segments
namespace: biological_process
def:
  "The process in which immunoglobulin genes are formed through recombination of the germline genetic elements, as known as immunoglobulin gene segments, within a single locus." [GOC:add, ISBN:0781735149]


id: GO:0016454
name: C-palmitoyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the transfer of a palmitoyl group to a carbon atom on the acceptor molecule." [GOC:ai]


id: GO:0016456
name: X chromosome located dosage compensation complex, transcription activating
namespace: cellular_component
def:
  "An RNA-protein complex localized to the X chromosome of males where it is required for the hyper-transcriptional activation of the X chromosome. An example of this is found in Drosophila melanogaster." [GOC:ma, GOC:mtg_sensu]


id: GO:0016457
namespace: biological_process
name:
  dosage compensation complex assembly involved in dosage compensation by hyperactivation of X chromosome

def:
  "The aggregation, arrangement and bonding together of proteins on DNA to form the complex that mediates dosage compensation on the X chromosome of the heterogametic sex, ultimately resulting in a two-fold increase in transcription from this chromosome. An example of this is found in Drosophila melanogaster." [GOC:jl]


id: GO:0016458
name: gene silencing
namespace: biological_process
def:
  "Any process carried out at the cellular level that results in either long-term transcriptional repression via action on chromatin structure or RNA mediated, post-transcriptional repression of gene expression." [GOC:dos, GOC:dph, GOC:jid, GOC:tb]


id: GO:0016459
name: myosin complex
namespace: cellular_component
def:
  "A protein complex, formed of one or more myosin heavy chains plus associated light chains and other proteins, that functions as a molecular motor; uses the energy of ATP hydrolysis to move actin filaments or to move vesicles or other cargo on fixed actin filaments; has magnesium-ATPase activity and binds actin. Myosin classes are distinguished based on sequence features of the motor, or head, domain, but also have distinct tail regions that are believed to bind specific cargoes." [GOC:mah, http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html, ISBN:96235764]


id: GO:0016460
name: myosin II complex
namespace: cellular_component
def:
  "A myosin complex containing two class II myosin heavy chains, two myosin essential light chains and two myosin regulatory light chains. Also known as classical myosin or conventional myosin, the myosin II class includes the major muscle myosin of vertebrate and invertebrate muscle, and is characterized by alpha-helical coiled coil tails that self assemble to form a variety of filament structures." [http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html, ISBN:96235764]


id: GO:0016462
name: pyrophosphatase activity
namespace: molecular_function
def:
  "Catalysis of the hydrolysis of a pyrophosphate bond between two phosphate groups, leaving one phosphate on each of the two fragments." [EC:3.6.1.-, GOC:curators]


id: GO:0016463
name: zinc-exporting ATPase activity
namespace: molecular_function
def:
  "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Zn2+(in) -> ADP + phosphate + Zn2+(out)." [EC:3.6.3.5]


id: GO:0016464
name: chloroplast protein-transporting ATPase activity
namespace: molecular_function
def:
  "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate; drives the transport of proteins into the chloroplast stroma." [EC:3.6.3.52]


id: GO:0016465
name: chaperonin ATPase complex
namespace: cellular_component
def:
  "Multisubunit protein complex with 2x7 (Type I, in most cells) or 2x8 (Type II, in Archaea) ATP-binding sites involved in maintaining an unfolded polypeptide structure before folding or to entry into mitochondria and chloroplasts." [EC:3.6.4.9]


id: GO:0016466
name: obsolete hydrogen-translocating A-type ATPase activity
namespace: molecular_function
def:
  "OBSOLETE. Catalysis of the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out). Found in archae." [TC:3.A.2.3.1]


id: GO:0016467
name: obsolete hydrogen-translocating F-type ATPase activity
namespace: molecular_function
def:
  "OBSOLETE. Catalysis of the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out). Found in eukaryotic mitochondria and chloroplasts and in bacteria." [TC:3.A.2.1.1, TC:3.A.2.1.3]


id: GO:0016468
name: obsolete sodium-translocating F-type ATPase activity
namespace: molecular_function
def:
  "OBSOLETE. Catalysis of the reaction: ATP + H2O + Na+(in) = ADP + phosphate + Na+(out). Found in eukaryotic mitochondria and chloroplasts and in bacteria." [TC:3.A.2.1.2]


id: GO:0016469
name: proton-transporting two-sector ATPase complex
namespace: cellular_component
def:
  "A large protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of protons across a membrane. The complex comprises a membrane sector (F0, V0, or A0) that carries out proton transport and a cytoplasmic compartment sector (F1, V1, or A1) that catalyzes ATP synthesis or hydrolysis. Two major types have been characterized: V-type ATPases couple ATP hydrolysis to the transport of protons across a concentration gradient, whereas F-type ATPases, also known as ATP synthases, normally run in the reverse direction to utilize energy from a proton concentration or electrochemical gradient to synthesize ATP. A third type, A-type ATPases have been found in archaea, and are closely related to eukaryotic V-type ATPases but are reversible." [GOC:mah, ISBN:0716743663, PMID:16691483]


id: GO:0016471
name: vacuolar proton-transporting V-type ATPase complex
namespace: cellular_component
def:
  "A proton-transporting two-sector ATPase complex found in the vacuolar membrane, where it acts as a proton pump to mediate acidification of the vacuolar lumen." [GOC:mah, ISBN:0716743663, PMID:16449553]


id: GO:0016472
name: sodium ion-transporting two-sector ATPase complex
namespace: cellular_component
def:
  "A large protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of sodium ions across a membrane. The complex comprises a membrane sector (F0 or V0) that carries out ion transport and a cytoplasmic compartment sector (F1 or V1) that catalyzes ATP synthesis or hydrolysis." [GOC:mah, PMID:14656431]


id: GO:0016473
name: sodium ion-transporting F-type ATPase complex
namespace: cellular_component
def:
  "A sodium ion-transporting two-sector ATPase complex that catalyzes the phosphorylation of ADP to ATP. The complex comprises a membrane sector (F0) that carries out proton transport and a cytoplasmic compartment sector (F1) that catalyzes ATP synthesis by a rotational mechanism." [GOC:mah, PMID:14656431]


id: GO:0016474
name: sodium ion-transporting V-type ATPase complex
namespace: cellular_component
def:
  "A sodium ion-transporting two-sector ATPase complex that couples ATP hydrolysis to the transport of sodium ions across a concentration gradient. The complex comprises a membrane sector (V0) that carries out proton transport and a cytoplasmic compartment sector (V1) that catalyzes ATP hydrolysis." [GOC:mah, PMID:15802565]


id: GO:0016475
name: detection of nuclear:cytoplasmic ratio
namespace: biological_process
def:
  "The process in which the size of the nucleus with respect to its cytoplasm is sensed by a cell." [GOC:jl]


id: GO:0016477
name: cell migration
namespace: biological_process
def:
  "The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues. Cell migration is a central process in the development and maintenance of multicellular organisms." [GOC:cjm, GOC:dph, GOC:ems, GOC:pf, http://en.wikipedia.org/wiki/Cell_migration]


id: GO:0016479
name: negative regulation of transcription from RNA polymerase I promoter
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase I promoter." [GOC:go_curators]


id: GO:0016480
name: negative regulation of transcription from RNA polymerase III promoter
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase III promoter." [GOC:go_curators]


id: GO:0016482
name: cytoplasmic transport
namespace: biological_process
def:
  "The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, or within the cytoplasm of a cell." [GOC:ai]


id: GO:0016484
name: obsolete proprotein convertase 2 activator activity
namespace: molecular_function
def:
  "OBSOLETE. Required for the maturation and activation of proprotein convertase 2." [GOC:ma, PMID:10749852]


id: GO:0016485
name: protein processing
namespace: biological_process
def:
  "Any protein maturation process achieved by the cleavage of a peptide bond or bonds within a protein. Protein maturation is the process leading to the attainment of the full functional capacity of a protein." [GOC:curators, GOC:jl, GOC:jsg]


id: GO:0016486
name: peptide hormone processing
namespace: biological_process
def:
  "The generation of a mature peptide hormone by posttranslational processing of a prohormone." [GOC:mah]


id: GO:0016487
name: farnesol metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving the sesquiterpenoid alcohol farnesol, 3,7,11-trimethyl-2,6,10,dodecatrien-1-ol." [GOC:go_curators]


id: GO:0016488
name: farnesol catabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the breakdown of the sesquiterpenoid alcohol farnesol, 3,7,11-trimethyl-2,6,10,dodecatrien-1-ol." [GOC:go_curators]


id: GO:0016490
name: structural constituent of peritrophic membrane
namespace: molecular_function
def:
  "The action of a molecule that contributes to the structural integrity of the peritrophic membrane, a tubular sheath of cuticle that shields the epithelial cells of the midgut from the gut contents. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238]


id: GO:0016491
name: oxidoreductase activity
namespace: molecular_function
def:
  "Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators]


id: GO:0016492
name: G-protein coupled neurotensin receptor activity
namespace: molecular_function
def:
  "Combining with the tridecapeptide neurotensin to initiate a G-protein mediated change in cell activity. A G-protein is a signal transduction molecule that alternates between an inactive GDP-bound and an active GTP-bound state." [PMID:10390649]


id: GO:0016493
name: C-C chemokine receptor activity
namespace: molecular_function
def:
  "Combining with a C-C chemokine and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. C-C chemokines do not have an amino acid between the first two cysteines of the characteristic four-cysteine motif." [GOC:signaling, PMID:8662823]


id: GO:0016494
name: C-X-C chemokine receptor activity
namespace: molecular_function
def:
  "Combining with a C-X-C chemokine and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. A C-X-C chemokine has a single amino acid between the first two cysteines of the characteristic four cysteine motif." [GOC:signaling, PMID:8662823]


id: GO:0016495
name: C-X3-C chemokine receptor activity
namespace: molecular_function
def:
  "Combining with a C-X3-C chemokine and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. A C-X3-C chemokine has three amino acids between the first two cysteines of the characteristic four-cysteine motif." [GOC:dph, GOC:signaling]


id: GO:0016496
name: substance P receptor activity
namespace: molecular_function
def:
  "Combining with substance P, the peptide Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met, to initiate a change in cell activity." [GOC:mah, ISBN:0198506732]


id: GO:0016497
name: substance K receptor activity
namespace: molecular_function
def:
  "Combining with substance K, the peptide His-Lys-Thr-Asp-Ser-Phe-Val-Gly-Leu-Met, to initiate a change in cell activity." [GOC:mah, ISBN:0198506732]


id: GO:0016498
name: neuromedin K receptor activity
namespace: molecular_function
def:
  "Combining with neuromedin K, the peptide Asp-Met-His-Asp-Phe-Phe-Val-Gly-Leu-Met to initiate a change in cell activity." [GOC:mah, ISBN:0198506732]


id: GO:0016502
name: nucleotide receptor activity
namespace: molecular_function
def:
  "Combining with a nucleotide and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. A nucleotide is a compound that consists of a nucleoside esterified with a phosphate molecule." [GOC:signaling, ISBN:0198506732]


id: GO:0016503
name: pheromone receptor activity
namespace: molecular_function
def:
  "Combining with a pheromone to initiate a change in cell activity. A pheromone is a substance used in olfactory communication between organisms of the same species eliciting a change in sexual or social behavior." [CHEBI:26013, GOC:hjd, ISBN:0198506732]


id: GO:0016504
name: peptidase activator activity
namespace: molecular_function
def:
  "Binds to and increases the activity of a peptidase, any enzyme that catalyzes the hydrolysis peptide bonds." [GOC:ai]


id: GO:0016505
name: peptidase activator activity involved in apoptotic process
namespace: molecular_function
def:
  "Increases the activity of a peptidase that is involved in the apoptotic process." [GOC:BHF, GOC:mah, GOC:mtg_apoptosis, GOC:rl]


id: GO:0016506
name: obsolete apoptosis activator activity
namespace: molecular_function
def:
  "OBSOLETE. The function held by products which directly activate any step in the process of apoptosis." [GOC:hb]


id: GO:0016507
name: mitochondrial fatty acid beta-oxidation multienzyme complex
namespace: cellular_component
def:
  "A complex that includes the long-chain 3-hydroxyacyl-CoA dehydrogenase and long-chain enoyl-CoA hydratase activities in two subunits (alpha and beta), catalyzing two steps of the fatty acid beta-oxidation cycle within the mitochondrial matrix." [GOC:ma]


id: GO:0016508
name: long-chain-enoyl-CoA hydratase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: a long-chain (3S)-3-hydroxyacyl-CoA = a long-chain trans-2-enoyl-CoA + H2O. A long-chain acyl-CoA is an acyl-CoA thioester where the acyl chain contains 13 to 22 carbon atoms." [EC:4.2.1.74]


id: GO:0016509
name: long-chain-3-hydroxyacyl-CoA dehydrogenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: (S)-3-hydroxyacyl-CoA + NAD(P)+ = 3-oxoacyl-CoA + NAD(P)H + H+, where the acyl group is a long-chain fatty acid residue. A long-chain fatty acid is a fatty acid with a chain length between C13 and C22." [CHEBI:15904, EC:1.1.1.211, GOC:pde]


id: GO:0016512
name: obsolete endothelin-converting enzyme 1 activity
namespace: molecular_function
def:
  "OBSOLETE. Catalysis of the formation of endothelin 1 by cleavage of the Trp21-Val22 bond in the precursor." [EC:3.4.24.71]


id: GO:0016513
name: core-binding factor complex
namespace: cellular_component
def:
  "A heterodimeric transcription factor complex that contains an alpha subunit (Runx1, Runx2 or Runx3 in human) that binds DNA and a non-DNA-binding beta subunit (CBFbeta), and binds to a consensus sequence 5'-YGYGGTY-3' found in several enhancers and promoters; the beta subunit enhances the DNA binding of the alpha subunit." [PMID:15156179, PMID:8497254]


id: GO:0016514
name: SWI/SNF complex
namespace: cellular_component
def:
  "A SWI/SNF-type complex that contains nine or more proteins, including both conserved (core) and nonconserved components; the Swi2/Snf2 ATPase is one of the core components." [GOC:mah, PMID:12672490]


id: GO:0016515
name: interleukin-13 receptor activity
namespace: molecular_function
def:
  "Combining with interleukin-13 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:jl, GOC:signaling]


id: GO:0016516
name: interleukin-4 receptor complex
namespace: cellular_component
def:
  "A protein complex that binds interleukin-4 (IL-4) and consists of an alpha chain that binds IL-4 with high affinity and a gamma common chain that also forms part of the interleukin-2 receptor." [PMID:10358772]


id: GO:0016517
name: interleukin-12 receptor activity
namespace: molecular_function
def:
  "Combining with interleukin-12 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:jl, GOC:signaling]


id: GO:0016518
name: interleukin-14 receptor activity
namespace: molecular_function
def:
  "Combining with interleukin-14 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:jl, GOC:signaling]


id: GO:0016519
name: gastric inhibitory peptide receptor activity
namespace: molecular_function
def:
  "Combining with gastric inhibitory peptide (GIP) and transmitting the signal across the membrane to activate an associated G-protein." [GOC:mah, PMID:8243312]


id: GO:0016520
name: growth hormone-releasing hormone receptor activity
namespace: molecular_function
def:
  "Combining with growth hormone-releasing hormone to initiate a change in cell activity." [PMID:12529933]


id: GO:0016521
name: pituitary adenylate cyclase activating polypeptide activity
namespace: molecular_function
def:
  "The action characteristic of pituitary adenylate cyclase activating polypeptide, a peptide produced in the hypothalamus that binds to receptors to exert pleiotropic effects including control of neurotransmitter release, vasodilation, bronchodilation, activation of intestinal motility, increase in insulin and histamine secretion, immune modulation, and stimulation of cell proliferation and differentiation." [GOC:mah, PMID:19805477]


id: GO:0016524
name: latrotoxin receptor activity
namespace: molecular_function
def:
  "Combining with alpha-latrotoxin, a potent presynaptic neurotoxin, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:jl, GOC:signaling, PMID:10025961]


id: GO:0016525
name: negative regulation of angiogenesis
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of angiogenesis." [GOC:go_curators]


id: GO:0016529
name: sarcoplasmic reticulum
namespace: cellular_component
def:
  "A fine reticular network of membrane-limited elements that pervades the sarcoplasm of a muscle cell; continuous over large portions of the cell and with the nuclear envelope; that part of the endoplasmic reticulum specialized for calcium release, uptake and storage." [GOC:mtg_muscle, ISBN:0124325653, ISBN:0198547684]


id: GO:0016531
name: copper chaperone activity
namespace: molecular_function
def:
  "Assists in the delivery of copper ions to target proteins or compartments." [PMID:10790544, PMID:11739376]


id: GO:0016532
name: superoxide dismutase copper chaperone activity
namespace: molecular_function
def:
  "A copper chaperone activity that specifically delivers copper to the Cu-Zn superoxide dismutase, to activate superoxide dismutase activity." [GOC:vw, http://link.springer-ny.com/link/service/journals/00335/papers/0011005/00110409.html, PMID:15064408, PMID:9295278]


id: GO:0016533
name: cyclin-dependent protein kinase 5 holoenzyme complex
namespace: cellular_component
def:
  "A protein complex that activates cyclin-dependent kinase 5; composed of regulatory and catalytic subunits." [PMID:15689152]


id: GO:0016538
name: cyclin-dependent protein serine/threonine kinase regulator activity
namespace: molecular_function
def:
  "Modulates the activity of a cyclin-dependent protein serine/threonine kinase, enzymes of the protein kinase family that are regulated through association with cyclins and other proteins." [GOC:pr, GOC:rn, PMID:7877684, PMID:9442875]


id: GO:0016539
name: intein-mediated protein splicing
namespace: biological_process
def:
  "The removal of an internal amino acid sequence (an intein) from a protein during protein maturation; the excision of inteins is precise and the N- and C-terminal exteins are joined by a normal peptide bond. Protein splicing involves 4 nucleophilic displacements by the 3 conserved splice junction residues." [GOC:ma, http://www.neb.com/neb/inteins.html]


id: GO:0016540
name: protein autoprocessing
namespace: biological_process
def:
  "Processing which a protein carries out itself. This involves actions such as the autolytic removal of residues to generate the mature form of the protein." [GOC:ai, PMID:9335337]


id: GO:0016541
name: obsolete intein
namespace: molecular_function
def:
  "OBSOLETE. Intervening protein sequence excised from a protein precursor in protein splicing; inteins catalyze their own excision and many also possess endonuclease activity." [GOC:mah, http://www.neb.com/neb/inteins.html, PMID:8165123]


id: GO:0016543
name: male courtship behavior, orientation prior to leg tapping and wing vibration
namespace: biological_process
def:
  "The process during courtship, where the male orients towards a potential partner. An example of this is found in Drosophila melanogaster." [GOC:sensu, PMID:11092827]


id: GO:0016544
name: male courtship behavior, tapping to detect pheromone
namespace: biological_process
def:
  "The process during courtship where the male insect taps the female with his frontal leg. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:11092827]


id: GO:0016545
name: male courtship behavior, veined wing vibration
namespace: biological_process
def:
  "The process during courtship where the male insect vibrates his wings. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:11092827]


id: GO:0016546
name: male courtship behavior, proboscis-mediated licking
namespace: biological_process
def:
  "The process during courtship where the male fly licks the genitalia of a stationary female fly with his proboscis. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:11092827]


id: GO:0016550
name: obsolete insertion or deletion editing
namespace: biological_process
def:
  "OBSOLETE. The insertion into or deletion from an RNA molecule of nucleotide residues not encoded in DNA; takes place during or after transcription." [PMID:11092837]


id: GO:0016551
name: obsolete posttranscriptional insertion or deletion editing
namespace: biological_process
def:
  "OBSOLETE. The insertion into or deletion from an RNA molecule of nucleotide residues not encoded in DNA; takes place after transcription." [PMID:11092837]


id: GO:0016552
name: obsolete cotranscriptional insertion or deletion editing
namespace: biological_process
def:
  "OBSOLETE. The insertion into or deletion from an RNA molecule of nucleotide residues not encoded in DNA; takes place during transcription." [PMID:11092837]


id: GO:0016553
name: base conversion or substitution editing
namespace: biological_process
def:
  "Any base modification or substitution events that result in alterations in the coding potential or structural properties of RNAs as a result of changes in the base-pairing properties of the modified ribonucleoside(s)." [PMID:11092837]


id: GO:0016554
name: cytidine to uridine editing
namespace: biological_process
def:
  "The conversion of a cytosine residue to uridine in an RNA molecule by deamination." [PMID:11092837]


id: GO:0016556
name: mRNA modification
namespace: biological_process
def:
  "The covalent alteration of one or more nucleotides within an mRNA molecule to produce an mRNA molecule with a sequence that differs from that coded genetically." [GOC:curators]


id: GO:0016557
name: peroxisome membrane biogenesis
namespace: biological_process
def:
  "The process in which a peroxisome membrane is synthesized, aggregates, and bonds together." [GOC:mah]


id: GO:0016558
name: protein import into peroxisome matrix
namespace: biological_process
def:
  "The import of proteins into the peroxisomal matrix. A peroxisome targeting signal (PTS) binds to a soluble receptor protein in the cytosol, and the resulting complex then binds to a receptor protein in the peroxisome membrane and is imported. The cargo protein is then released into the peroxisome matrix." [ISBN:0716731363, PMID:11687502, PMID:11988772]


id: GO:0016559
name: peroxisome fission
namespace: biological_process
def:
  "The division of a mature peroxisome within a cell to form two or more separate peroxisome compartments." [GOC:mah, PMID:11687502, PMID:14754507]


id: GO:0016560
name: protein import into peroxisome matrix, docking
namespace: biological_process
def:
  "The process in which a complex formed of a peroxisome targeting sequence (PTS) receptor bound to a PTS-bearing protein docks with translocation machinery in the peroxisomal membrane." [PMID:11687502, PMID:11988772, PMID:14754507]


id: GO:0016561
name: protein import into peroxisome matrix, translocation
namespace: biological_process
def:
  "The process in which proteins are moved across the peroxisomal membrane into the matrix. It is likely that the peroxisome targeting sequence receptor remains associated with cargo proteins during translocation." [PMID:11687502]


id: GO:0016562
name: protein import into peroxisome matrix, receptor recycling
namespace: biological_process
def:
  "The process in which peroxisome targeting sequence receptors dissociates from cargo proteins and are returned to the cytosol." [PMID:11687502]


id: GO:0016563
name: obsolete transcription activator activity
namespace: molecular_function
def:
  "OBSOLETE. Any transcription regulator activity required for initiation or upregulation of transcription." [GOC:jl, ISBN:0124325653]


id: GO:0016564
name: obsolete transcription repressor activity
namespace: molecular_function
def:
  "OBSOLETE. Any transcription regulator activity that prevents or downregulates transcription." [GOC:mah]


id: GO:0016565
name: obsolete general transcriptional repressor activity
namespace: molecular_function
def:
  "OBSOLETE. Any activity that stops or downregulates transcription of genes globally, and is not specific to a particular gene or gene set." [GOC:mah]


id: GO:0016566
name: obsolete specific transcriptional repressor activity
namespace: molecular_function
def:
  "OBSOLETE. Any activity that stops or downregulates transcription of specific genes or sets of genes." [GOC:mah]


id: GO:0016568
name: chromatin modification
namespace: biological_process
def:
  "The alteration of DNA, protein, or sometimes RNA, in chromatin, which may result in changing the chromatin structure." [GOC:mah, PMID:20404130]


id: GO:0016569
name: covalent chromatin modification
namespace: biological_process
def:
  "The alteration of DNA or protein in chromatin by the covalent addition or removal of chemical groups." [GOC:mah]


id: GO:0016580
name: Sin3 complex
namespace: cellular_component
def:
  "A multiprotein complex that functions broadly in eukaryotic organisms as a transcriptional repressor of protein-coding genes, through the gene-specific deacetylation of histones. Amongst its subunits, the Sin3 complex contains Sin3-like proteins, and a number of core proteins that are shared with the NuRD complex (including histone deacetylases and histone binding proteins). The Sin3 complex does not directly bind DNA itself, but is targeted to specific genes through protein-protein interactions with DNA-binding proteins." [PMID:10589671, PMID:11743021, PMID:12865422]


id: GO:0016581
name: NuRD complex
namespace: cellular_component
def:
  "An approximately 2 MDa multi-subunit complex that exhibits ATP-dependent chromatin remodeling activity in addition to histone deacetylase (HDAC) activity, and has been shown to establish transcriptional repression of a number of target genes in vertebrates, invertebrates and fungi. Amongst its subunits, the NuRD complex contains histone deacetylases, histone binding proteins and Mi-2-like proteins." [PMID:10589671, PMID:11743021, PMID:17289569]


id: GO:0016582
name: non-covalent chromatin modification
namespace: biological_process
def:
  "The alteration of DNA or protein in chromatin by the non-covalent addition or removal of chemical groups." [GOC:jl]


id: GO:0016584
name: nucleosome positioning
namespace: biological_process
def:
  "Ordering of successions of nucleosomes into regular arrays so that nucleosomes are positioned at defined distances from one another." [GOC:bf, PMID:11447119, PMID:8676389]


id: GO:0016586
name: RSC complex
namespace: cellular_component
def:
  "A protein complex similar to, but more abundant than, the Swi/Snf complex. The RSC complex is generally recruited to RNA polymerase III promoters and is specifically recruited to RNA polymerase II promoters by transcriptional activators and repressors; it is also involved in non-homologous end joining." [GOC:rb, PMID:11937489, PMID:12672490, PMID:15870268, PMID:19355820, PMID:8980231]


id: GO:0016587
name: Isw1 complex
namespace: cellular_component
def:
  "A protein complex that contains an Isw1 subunit from the ISWI-family of ATPases and acts to modify chromatin structure." [GOC:krc, GOC:mah, PMID:15020051, PMID:15284901, PMID:16568949, PMID:21810179]


id: GO:0016589
name: NURF complex
namespace: cellular_component
def:
  "An ISWI complex that contains an ATPase subunit of the ISWI family (SNF2L in mammals), a NURF301 homolog (BPTF in humans), and additional subunits, though the composition of these additional subunits varies slightly with species. NURF is involved in regulation of transcription from TRNA polymerase II promoters." [GOC:bf, GOC:krc, PMID:10779516, PMID:11279013, PMID:15284901, PMID:16568949, PMID:21810179]


id: GO:0016590
name: ACF complex
namespace: cellular_component
def:
  "An ISWI complex that contains an ATPase subunit of the ISWI family (SNF2H in mammals, Isw2 in S. cerevisiae), an ACF1 homolog, and generally no other subunits, though Xenopus is an exception with a third non-conserved subunit. ACF plays roles in regulation of RNA polymerase II transcription and in DNA replication and repair." [GOC:bf, GOC:krc, PMID:12192034, PMID:15284901, PMID:16568949, PMID:21810179]


id: GO:0016591
name: DNA-directed RNA polymerase II, holoenzyme
namespace: cellular_component
def:
  "Large protein complex composed of the RNA polymerase core complex and a variety of other proteins including transcription factor complexes TFIIA, D, E, F, and H which are required for promoter recognition, and the Mediator subcomplex. Catalyzes the synthesis of eukaryotic pre-mRNA." [GOC:jl, PMID:15196470, Wikipedia:Rna_polymerase_ii]


id: GO:0016592
name: mediator complex
namespace: cellular_component
def:
  "A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The mediator complex is required for activation of transcription of most protein-coding genes, but can also act as a transcriptional corepressor. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins." [PMID:11454195, PMID:16168358, PMID:17870225]


id: GO:0016593
name: Cdc73/Paf1 complex
namespace: cellular_component
def:
  "A multiprotein complex that associates with RNA polymerase II and general RNA polymerase II transcription factor complexes and may be involved in both transcriptional initiation and elongation. In Saccharomyces the complex contains Paf1p, Cdc73p, Ctr9p, Rtf1p, and Leo1p." [PMID:11884586]


id: GO:0016595
name: glutamate binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with glutamate, the anion of 2-aminopentanedioic acid." [GOC:ai]


id: GO:0016597
name: amino acid binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with an amino acid, organic acids containing one or more amino substituents." [GOC:ai]


id: GO:0016598
name: protein arginylation
namespace: biological_process
def:
  "The conjugation of arginine to the N-terminal aspartate or glutamate of a protein; required for the degradation of the protein via the ubiquitin pathway." [PMID:17896865]


id: GO:0016600
name: flotillin complex
namespace: cellular_component
def:
  "A protein complex that contains flotillin-1 and flotillin-2, and may contain associated proteins. Flotillins associate into membrane microdomains resembling caveolae." [PMID:17206938, PMID:17600709]


id: GO:0016601
name: Rac protein signal transduction
namespace: biological_process
def:
  "A series of molecular signals within the cell that are mediated by a member of the Rac family of proteins switching to a GTP-bound active state." [GOC:bf]


id: GO:0016602
name: CCAAT-binding factor complex
namespace: cellular_component
def:
  "A heteromeric transcription factor complex that binds to the CCAAT-box upstream of promoters; functions as both an activator and a repressor, depending on its interacting cofactors. Typically trimeric consisting of NFYA, NFYB and NFYC subunits. In Saccharomyces, it activates the transcription of genes in response to growth in a nonfermentable carbon source and consists of four known subunits: HAP2, HAP3, HAP4 and HAP5." [GOC:bm, PMID:7828851]


id: GO:0016604
name: nuclear body
namespace: cellular_component
def:
  "Extra-nucleolar nuclear domains usually visualized by confocal microscopy and fluorescent antibodies to specific proteins." [GOC:ma, PMID:10330182]


id: GO:0016605
name: PML body
namespace: cellular_component
def:
  "A class of nuclear body; they react against SP100 auto-antibodies (PML, promyelocytic leukemia); cells typically contain 10-30 PML bodies per nucleus; alterations in the localization of PML bodies occurs after viral infection." [GOC:ma, PMID:10944585]


id: GO:0016606
name: LYSP100-associated nuclear domain
namespace: cellular_component
def:
  "A nuclear body that is enriched in the lymphoid cell-specific protein LYSp100B; LANDs are globular, electron-dense structures and are morphologically distinct from the annular structures characteristic of PML bodies." [PMID:10921892, PMID:8695863]


id: GO:0016607
name: nuclear speck
namespace: cellular_component
def:
  "A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy." [http://www.cellnucleus.com/]


id: GO:0016608
name: growth hormone-releasing hormone activity
namespace: molecular_function
def:
  "The action characteristic of growth hormone-releasing hormone, any of a family of peptide hormones that act on the anterior pituitary to stimulate the secretion of growth hormone and exert a trophic effect on the gland." [ISBN:0198506732]


id: GO:0016610
name: nitrogenase complex
namespace: cellular_component
def:
  "An enzyme complex composed of two proteins, dinitrogenase and nitrogenase reductase; dinitrogenase is tetrameric with an alpha2-beta2 structure and nitrogenase reductase is a homodimer, and both are associated with metal ions, which differ between species. Both proteins are required for the enzyme activity of the complex, the formation of oxidized ferredoxin and ammonia from reduced ferredoxin and nitrogen." [EC:1.18.6.1, MetaCyc:CPLX-186, MetaCyc:CPLX-525]


id: GO:0016611
name: iron-iron nitrogenase complex
namespace: cellular_component
def:
  "An enzyme complex containing an iron-iron cluster found in species such as the photosynthetic bacterium Rhodobacter capsulatus. It is composed of two main subunits, dinitrogenase and nitrogenase reductase. Dinitrogenase, the iron-iron containing subunit, has an alpha1-beta2 or alpha2-beta2 structure, and the nitrogenase reductase subunit is a homodimer. Functions in the catalysis of the formation of oxidized ferredoxin and ammonia from reduced ferredoxin and nitrogen." [EC:1.18.6.1, GOC:jl, PMID:11848850]


id: GO:0016612
name: molybdenum-iron nitrogenase complex
namespace: cellular_component
def:
  "An enzyme complex containing a molybdenum-iron cluster found in many species. It is composed of two proteins, dinitrogenase and nitrogenase reductase; dinitrogenase, the molybdenum-iron protein, is tetrameric with an alpha2-beta2 structure, and nitrogenase reductase is a homodimer." [EC:1.18.6.1]


id: GO:0016613
name: vanadium-iron nitrogenase complex
namespace: cellular_component
def:
  "An enzyme complex containing a vanadium-iron cluster found in some species, such as Azotobacter vinelandii. It is composed of two proteins, dinitrogenase and nitrogenase reductase; dinitrogenase, the vanadium-iron protein, is tetrameric with an alpha2-beta2 structure, and nitrogenase reductase is a homodimer." [EC:1.18.6.1, PMID:3474027]


id: GO:0016614
name: oxidoreductase activity, acting on CH-OH group of donors
namespace: molecular_function
def:
  "Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group act as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]


id: GO:0016615
name: malate dehydrogenase activity
namespace: molecular_function
def:
  "Catalysis of the reversible conversion of pyruvate or oxaloacetate to malate." [GOC:mah, ISBN:0582227089]


id: GO:0016616
name: oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
namespace: molecular_function
def:
  "Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP." [EC:1.1.1.-, GOC:ai]


id: GO:0016620
name: oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
namespace: molecular_function
def:
  "Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces NAD or NADP." [GOC:jl]


id: GO:0016621
name: cinnamoyl-CoA reductase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: cinnamaldehyde + CoA + NADP+ = cinnamoyl-CoA + NADPH + H+." [EC:1.2.1.44]


id: GO:0016622
name: oxidoreductase activity, acting on the aldehyde or oxo group of donors, cytochrome as acceptor
namespace: molecular_function
def:
  "Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces a cytochrome." [GOC:jl]


id: GO:0016623
name: oxidoreductase activity, acting on the aldehyde or oxo group of donors, oxygen as acceptor
namespace: molecular_function
def:
  "Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces oxygen." [GOC:jl]


id: GO:0016624
name: oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
namespace: molecular_function
def:
  "Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces a disulfide." [GOC:jl]


id: GO:0016625
namespace: molecular_function
name:
  oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor

def:
  "Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces an iron-sulfur protein." [GOC:jl]


id: GO:0016626
name: obsolete oxidoreductase activity, acting on the aldehyde or oxo group of donors, other acceptors
namespace: molecular_function
def:
  "OBSOLETE. Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces an acceptor other than NAD, NADP, oxygen, an iron-sulfur protein, disulphide or a cytochrome." [GOC:jl]


id: GO:0016627
name: oxidoreductase activity, acting on the CH-CH group of donors
namespace: molecular_function
def:
  "Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]


id: GO:0016628
name: oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor
namespace: molecular_function
def:
  "Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces NAD or NADP." [GOC:jl]


id: GO:0016629
name: 12-oxophytodienoate reductase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 8-[(1R,2R)-3-oxo-2-{(Z)-pent-2-en-1-yl}cyclopentyl]octanoate + NADP(+) = (15Z)-12-oxophyto-10,15-dienoate + H(+) + NADPH." [EC:1.3.1.42, RHEA:21891]


id: GO:0016630
name: protochlorophyllide reductase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: chlorophyllide a + NADP+ = protochlorophyllide + NADPH + H+." [EC:1.3.1.33]


id: GO:0016631
name: enoyl-[acyl-carrier-protein] reductase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: acyl-[acyl-carrier protein] + NAD(P)+ = trans-2,3-dehydroacyl-[acyl-carrier protein] + NAD(P)H + H+." [EC:1.3.1.9, GOC:rb]


id: GO:0016632
name: oxidoreductase activity, acting on the CH-CH group of donors, cytochrome as acceptor
namespace: molecular_function
def:
  "Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a cytochrome." [GOC:jl]


id: GO:0016633
name: galactonolactone dehydrogenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: L-galactono-1,4-lactone + 2 ferricytochrome c = L-ascorbate + 2 ferrocytochrome c." [EC:1.3.2.3]


id: GO:0016634
name: oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor
namespace: molecular_function
def:
  "Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces oxygen." [GOC:jl]


id: GO:0016635
namespace: molecular_function
name:
  oxidoreductase activity, acting on the CH-CH group of donors, quinone or related compound as acceptor

def:
  "Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a quinone or related compound." [GOC:jl]


id: GO:0016636
name: oxidoreductase activity, acting on the CH-CH group of donors, iron-sulfur protein as acceptor
namespace: molecular_function
def:
  "Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces an iron-sulfur protein." [GOC:jl]


id: GO:0016637
name: obsolete oxidoreductase activity, acting on the CH-CH group of donors, other acceptors
namespace: molecular_function
def:
  "OBSOLETE. Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces an acceptor other than quinone or related compound, a cytochrome, an iron-sulfur protein, NAD, NADP or oxygen." [GOC:jl]


id: GO:0016638
name: oxidoreductase activity, acting on the CH-NH2 group of donors
namespace: molecular_function
def:
  "Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]


id: GO:0016639
name: oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor
namespace: molecular_function
def:
  "Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces NAD+ or NADP." [GOC:ai]


id: GO:0016640
name: oxidoreductase activity, acting on the CH-NH2 group of donors, cytochrome as acceptor
namespace: molecular_function
def:
  "Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces a cytochrome molecule." [GOC:ai]


id: GO:0016641
name: oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor
namespace: molecular_function
def:
  "Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces an oxygen molecule." [GOC:ai]


id: GO:0016642
name: oxidoreductase activity, acting on the CH-NH2 group of donors, disulfide as acceptor
namespace: molecular_function
def:
  "Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces a disulfide group." [GOC:ai]


id: GO:0016643
name: oxidoreductase activity, acting on the CH-NH2 group of donors, iron-sulfur protein as acceptor
namespace: molecular_function
def:
  "Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces an iron-sulfur protein." [GOC:ai]


id: GO:0016644
name: obsolete oxidoreductase activity, acting on the CH-NH2 group of donors, other acceptors
namespace: molecular_function
def:
  "OBSOLETE. Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces an acceptor other than a cytochrome, disulfide, an iron-sulfur protein, NAD, NADP or oxygen." [GOC:ai]


id: GO:0016645
name: oxidoreductase activity, acting on the CH-NH group of donors
namespace: molecular_function
def:
  "Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]


id: GO:0016646
name: oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor
namespace: molecular_function
def:
  "Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH group acts as a hydrogen or electron donor and reduces NAD or NADP." [GOC:jl]


id: GO:0016647
name: oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor
namespace: molecular_function
def:
  "Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH group acts as a hydrogen or electron donor and reduces oxygen." [GOC:jl]


id: GO:0016648
name: oxidoreductase activity, acting on the CH-NH group of donors, disulfide as acceptor
namespace: molecular_function
def:
  "Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH group acts as a hydrogen or electron donor and reduces disulfide." [GOC:jl]


id: GO:0016649
namespace: molecular_function
name:
  oxidoreductase activity, acting on the CH-NH group of donors, quinone or similar compound as acceptor

def:
  "Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH group acts as a hydrogen or electron donor and reduces quinone or similar compound." [GOC:jl]


id: GO:0016650
name: obsolete oxidoreductase activity, acting on the CH-NH group of donors, other acceptors
namespace: molecular_function
def:
  "OBSOLETE. Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH group acts as a hydrogen or electron donor and reduces an acceptor other than quinone or similar compound, disulfide, NAD, NADP, oxygen or a flavin." [GOC:jl]


id: GO:0016651
name: oxidoreductase activity, acting on NAD(P)H
namespace: molecular_function
def:
  "Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]


id: GO:0016652
name: oxidoreductase activity, acting on NAD(P)H, NAD(P) as acceptor
namespace: molecular_function
def:
  "Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces NAD+ or NADP." [GOC:ai]


id: GO:0016653
name: oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor
namespace: molecular_function
def:
  "Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a heme protein." [GOC:ai]


id: GO:0016655
name: oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor
namespace: molecular_function
def:
  "Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a quinone or a similar acceptor molecule." [GOC:ai]


id: GO:0016657
name: oxidoreductase activity, acting on NAD(P)H, nitrogenous group as acceptor
namespace: molecular_function
def:
  "Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a nitrogenous group." [GOC:ai]


id: GO:0016659
name: obsolete oxidoreductase activity, acting on NADH or NADPH, other acceptor
namespace: molecular_function
def:
  "OBSOLETE. Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces an acceptor other than disulfide, a heme protein, NAD, NADP, a nitrogenous group, a quinone or similar compound or oxygen." [GOC:jl]


id: GO:0016661
name: oxidoreductase activity, acting on other nitrogenous compounds as donors
namespace: molecular_function
def:
  "Catalysis of an oxidation-reduction (redox) reaction in which a nitrogenous group, excluding NH and NH2 groups, acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]


id: GO:0016662
name: oxidoreductase activity, acting on other nitrogenous compounds as donors, cytochrome as acceptor
namespace: molecular_function
def:
  "Catalysis of an oxidation-reduction (redox) reaction in which a nitrogenous group, excluding NH and NH2 groups, acts as a hydrogen or electron donor and reduces a cytochrome." [GOC:jl]


id: GO:0016663
name: oxidoreductase activity, acting on other nitrogenous compounds as donors, oxygen as acceptor
namespace: molecular_function
def:
  "Catalysis of an oxidation-reduction (redox) reaction in which a nitrogenous group, excluding NH and NH2 groups, acts as a hydrogen or electron donor and reduces oxygen." [GOC:jl]


id: GO:0016664
namespace: molecular_function
name:
  oxidoreductase activity, acting on other nitrogenous compounds as donors, iron-sulfur protein as acceptor

def:
  "Catalysis of an oxidation-reduction (redox) reaction in which a nitrogenous group, excluding NH and NH2 groups, acts as a hydrogen or electron donor and reduces an iron-sulfur protein." [GOC:jl]


id: GO:0016665
name: obsolete oxidoreductase activity, acting on other nitrogenous compounds as donors, other acceptors
namespace: molecular_function
def:
  "OBSOLETE. Catalysis of an oxidation-reduction (redox) reaction in which a nitrogenous group, excluding NH and NH2 groups, acts as a hydrogen or electron donor and reduces an acceptor other than a cytochrome, an iron-sulfur protein, oxygen, NAD or NADP." [GOC:jl]


id: GO:0016667
name: oxidoreductase activity, acting on a sulfur group of donors
namespace: molecular_function
def:
  "Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]


id: GO:0016668
name: oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor
namespace: molecular_function
def:
  "Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces NAD or NADP." [GOC:jl]


id: GO:0016669
name: oxidoreductase activity, acting on a sulfur group of donors, cytochrome as acceptor
namespace: molecular_function
def:
  "Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces a cytochrome." [GOC:jl]


id: GO:0016670
name: oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor
namespace: molecular_function
def:
  "Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces oxygen." [GOC:jl]


id: GO:0016671
name: oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor
namespace: molecular_function
def:
  "Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces disulfide." [GOC:jl]


id: GO:0016672
namespace: molecular_function
name:
  oxidoreductase activity, acting on a sulfur group of donors, quinone or similar compound as acceptor

def:
  "Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces quinone or a related compound." [GOC:jl]


id: GO:0016673
name: oxidoreductase activity, acting on a sulfur group of donors, iron-sulfur protein as acceptor
namespace: molecular_function
def:
  "Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces an iron-sulfur protein." [GOC:jl]


id: GO:0016674
name: obsolete oxidoreductase activity, acting on sulfur group of donors, other acceptors
namespace: molecular_function
def:
  "OBSOLETE. Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces an acceptor other than quinone or a related compound, oxygen, NAD, NADP, an iron-sulfur protein, disulfide or a cytochrome." [GOC:jl]


id: GO:0016675
name: oxidoreductase activity, acting on a heme group of donors
namespace: molecular_function
def:
  "Catalysis of an oxidation-reduction (redox) reaction in which a heme group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]


id: GO:0016676
name: oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
namespace: molecular_function
def:
  "Catalysis of an oxidation-reduction (redox) reaction in which a heme group acts as a hydrogen or electron donor and reduces oxygen." [GOC:jl]


id: GO:0016677
name: oxidoreductase activity, acting on a heme group of donors, nitrogenous group as acceptor
namespace: molecular_function
def:
  "Catalysis of an oxidation-reduction (redox) reaction in which a heme group acts as a hydrogen or electron donor and reduces a nitrogenous group." [GOC:jl]


id: GO:0016678
name: obsolete oxidoreductase activity, acting on heme group of donors, other acceptors
namespace: molecular_function
def:
  "OBSOLETE. Catalysis of an oxidation-reduction (redox) reaction in which a heme group acts as a hydrogen or electron donor and reduces an acceptor other than a nitrogenous group or oxygen." [GOC:jl]


id: GO:0016679
name: oxidoreductase activity, acting on diphenols and related substances as donors
namespace: molecular_function
def:
  "Catalysis of an oxidation-reduction (redox) reaction in which a diphenol or related substance acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]


id: GO:0016680
namespace: molecular_function
name:
  oxidoreductase activity, acting on diphenols and related substances as donors, NAD or NADP as acceptor

def:
  "Catalysis of an oxidation-reduction (redox) reaction in which a diphenol, or related compound, acts as a hydrogen or electron donor and reduces NAD or NADP." [GOC:jl]


id: GO:0016681
namespace: molecular_function
name:
  oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor

def:
  "Catalysis of an oxidation-reduction (redox) reaction in which a diphenol, or related compound, acts as a hydrogen or electron donor and reduces a cytochrome." [GOC:jl]


id: GO:0016682
name: oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
namespace: molecular_function
def:
  "Catalysis of an oxidation-reduction (redox) reaction in which a diphenol, or related compound, acts as a hydrogen or electron donor and reduces oxygen." [GOC:jl]


id: GO:0016683
namespace: molecular_function
name:
  obsolete oxidoreductase activity, acting on diphenols and related substances as donors, other acceptors

def:
  "OBSOLETE. Catalysis of an oxidation-reduction (redox) reaction in which a diphenol, or related compound, acts as a hydrogen or electron donor and reduces an acceptor other than a cytochrome, NAD, NADP or oxygen." [GOC:jl]


id: GO:0016684
name: oxidoreductase activity, acting on peroxide as acceptor
namespace: molecular_function
def:
  "Catalysis of an oxidation-reduction (redox) reaction in which the peroxide group acts as a hydrogen or electron acceptor." [GOC:ai]


id: GO:0016688
name: L-ascorbate peroxidase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: L-ascorbate + hydrogen peroxide = dehydroascorbate + 2 H2O." [EC:1.11.1.11]


id: GO:0016690
name: diarylpropane peroxidase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: (3,4-dimethoxyphenyl)methanol + H2O2 = 3,4-dimethoxybenzaldehyde + 2 H2O." [EC:1.11.1.14]


id: GO:0016691
name: chloride peroxidase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 2 R-H + 2 chloride + hydrogen peroxide = 2 R-Cl + 2 H2O." [EC:1.11.1.10]


id: GO:0016695
name: oxidoreductase activity, acting on hydrogen as donor
namespace: molecular_function
def:
  "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen acts as an electron donor." [GOC:jl]


id: GO:0016696
name: oxidoreductase activity, acting on hydrogen as donor, NAD or NADP as acceptor
namespace: molecular_function
def:
  "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen acts as an electron donor and reduces NAD or NADP." [GOC:jl]


id: GO:0016697
name: oxidoreductase activity, acting on hydrogen as donor, cytochrome as acceptor
namespace: molecular_function
def:
  "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen acts as an electron donor and reduces a cytochrome." [GOC:jl]


id: GO:0016699
name: oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
namespace: molecular_function
def:
  "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen acts as an electron donor and reduces an iron-sulfur protein." [GOC:jl]


id: GO:0016700
name: obsolete oxidoreductase activity, acting on hydrogen as donor, other acceptors
namespace: molecular_function
def:
  "OBSOLETE. Catalysis of an oxidation-reduction (redox) reaction in which hydrogen is the electron donor and reduces an acceptor other than a cytochrome, an iron-sulfur protein, NAD, NADP or a quinone or similar compound." [GOC:ai]


id: GO:0016701
name: oxidoreductase activity, acting on single donors with incorporation of molecular oxygen
namespace: molecular_function
def:
  "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from one donor, and molecular oxygen is incorporated into a donor." [GOC:mah]


id: GO:0016702
namespace: molecular_function
name:
  oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen

def:
  "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from one donor, and two oxygen atoms is incorporated into a donor." [GOC:mah]


id: GO:0016703
namespace: molecular_function
name:
  oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases)

def:
  "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from one donor, and one oxygen atom is incorporated into a donor." [GOC:mah]


id: GO:0016704
namespace: molecular_function
name:
  obsolete oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, miscellaneous

def:
  "OBSOLETE. A grouping term for oxidoreductases acting on single donors with incorporation of molecular oxygen that cannot be more accurated categorized." [GOC:ai]


id: GO:0016705
namespace: molecular_function
name:
  oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen

def:
  "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah]


id: GO:0016706
namespace: molecular_function
name:
  oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors

def:
  "Catalysis of the reaction: A + 2-oxoglutarate + O2 = B + succinate + CO2. This is an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from 2-oxoglutarate and one other donor, and one atom of oxygen is incorporated into each donor." [GOC:mah]


id: GO:0016707
name: gibberellin 3-beta-dioxygenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: a gibberellin + 2-oxoglutarate + O2 = a 3-beta-hydroxy-gibberellin + succinate + CO2." [EC:1.14.11.15, GOC:kad]


id: GO:0016708
namespace: molecular_function
name:
  oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of two atoms of oxygen into one donor

def:
  "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from NADH or NADPH and one other donor, and two atoms of oxygen are incorporated into one donor." [GOC:mah]


id: GO:0016709
namespace: molecular_function
name:
  oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen

def:
  "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from NADH or NADPH and one other donor, and one atom of oxygen is incorporated into one donor." [GOC:mah]


id: GO:0016710
name: trans-cinnamate 4-monooxygenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: trans-cinnamate + NADPH + H+ + O2 = 4-hydroxycinnamate + NADP+ + H2O." [EC:1.14.13.11]


id: GO:0016711
name: flavonoid 3'-monooxygenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: a flavonoid + NADPH + H+ + O2 = 3'-hydroxyflavonoid + NADP+ + H2O." [EC:1.14.13.21]


id: GO:0016712
namespace: molecular_function
name:
  oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen

def:
  "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from reduced flavin or flavoprotein and one other donor, and one atom of oxygen is incorporated into one donor." [GOC:mah]


id: GO:0016713
namespace: molecular_function
name:
  oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen

def:
  "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from reduced iron-sulfur protein and one other donor, and one atom of oxygen is incorporated into one donor." [GOC:mah]


id: GO:0016714
namespace: molecular_function
name:
  oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen

def:
  "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from reduced pteridine and one other donor, and one atom of oxygen is incorporated into one donor." [GOC:mah]


id: GO:0016715
namespace: molecular_function
name:
  oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen

def:
  "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from reduced ascorbate and one other donor, and one atom of oxygen is incorporated into one donor." [GOC:mah]


id: GO:0016716
namespace: molecular_function
name:
  oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen

def:
  "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and one atom of oxygen is incorporated into one donor." [GOC:mah]


id: GO:0016717
namespace: molecular_function
name:
  oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water

def:
  "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced to two molecules of water." [GOC:mah]


id: GO:0016718
namespace: molecular_function
name:
  obsolete oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, miscellaneous

def:
  "OBSOLETE. A grouping term for oxidoreductases, acting on paired donors with incorporation or reduction of molecular oxygen, that cannot be more accurately categorized." [GOC:ai]


id: GO:0016719
name: carotene 7,8-desaturase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: neurosporene + donor-H2 + O2 = lycopene + acceptor + 2 H2O." [EC:1.14.99.30]


id: GO:0016720
name: delta12-fatty acid dehydrogenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: AH(2) + linoleate + O(2) = A + crepenynate + 2 H(2)O." [EC:1.14.99.33, RHEA:23459]


id: GO:0016721
name: oxidoreductase activity, acting on superoxide radicals as acceptor
namespace: molecular_function
def:
  "Catalysis of an oxidation-reduction (redox) reaction in which a superoxide radical (O2- or O2.-) acts as a hydrogen or electron acceptor." [GOC:ai]


id: GO:0016722
name: oxidoreductase activity, oxidizing metal ions
namespace: molecular_function
def:
  "Catalysis of an oxidation-reduction in which the oxidation state of metal ion is altered." [GOC:mah]


id: GO:0016723
name: oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor
namespace: molecular_function
def:
  "Catalysis of an oxidation-reduction in which the oxidation state of metal ion is altered and NAD+ or NADP+ acts as an electron acceptor." [GOC:mah]


id: GO:0016724
name: oxidoreductase activity, oxidizing metal ions, oxygen as acceptor
namespace: molecular_function
def:
  "Catalysis of an oxidation-reduction in which the oxidation state of metal ion is altered and oxygen acts as an electron acceptor." [GOC:mah]


id: GO:0016725
name: oxidoreductase activity, acting on CH or CH2 groups
namespace: molecular_function
def:
  "Catalysis of an oxidation-reduction (redox) reaction in which a CH2 group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]


id: GO:0016726
name: oxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor
namespace: molecular_function
def:
  "Catalysis of an oxidation-reduction (redox) reaction in which a CH2 group acts as a hydrogen or electron donor and reduces NAD+ or NADP." [GOC:ai]


id: GO:0016727
name: oxidoreductase activity, acting on CH or CH2 groups, oxygen as acceptor
namespace: molecular_function
def:
  "Catalysis of an oxidation-reduction (redox) reaction in which a CH2 group acts as a hydrogen or electron donor and reduces an oxygen molecule." [GOC:ai]


id: GO:0016728
name: oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor
namespace: molecular_function
def:
  "Catalysis of an oxidation-reduction (redox) reaction in which a CH2 group acts as a hydrogen or electron donor and reduces a disulfide group." [GOC:ai]


id: GO:0016729
name: obsolete oxidoreductase activity, acting on CH2 groups, other acceptors
namespace: molecular_function
def:
  "OBSOLETE. Catalysis of an oxidation-reduction (redox) reaction in which a CH2 group acts as a hydrogen or electron donor and reduces an acceptor other than disulfide, NAD, NADP or oxygen." [GOC:jl]


id: GO:0016730
name: oxidoreductase activity, acting on iron-sulfur proteins as donors
namespace: molecular_function
def:
  "Catalysis of an oxidation-reduction (redox) reaction in which an iron-sulfur protein acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]


id: GO:0016731
name: oxidoreductase activity, acting on iron-sulfur proteins as donors, NAD or NADP as acceptor
namespace: molecular_function
def:
  "Catalysis of an oxidation-reduction (redox) reaction in which an iron-sulfur protein acts as a hydrogen or electron donor and reduces NAD or NADP." [GOC:jl]


id: GO:0016732
name: oxidoreductase activity, acting on iron-sulfur proteins as donors, dinitrogen as acceptor
namespace: molecular_function
def:
  "Catalysis of an oxidation-reduction (redox) reaction in which an iron-sulfur protein acts as a hydrogen or electron donor and reduces dinitrogen." [GOC:jl]


id: GO:0016733
name: obsolete iron-iron nitrogenase activity
namespace: molecular_function
def:
  "OBSOLETE. Catalysis of the reaction: 8 reduced ferredoxin + 8 H+ + N2 + 16 ATP = 8 oxidized ferredoxin + 2 NH3 + 16 ADP + 16 phosphate." [EC:1.18.6.1]


id: GO:0016735
name: obsolete vanadium-iron nitrogenase activity
namespace: molecular_function
def:
  "OBSOLETE. Catalysis of the reaction: 8 reduced ferredoxin + 8 H+ + nitrogen + 16 ATP = 8 oxidized ferredoxin + 2 NH3 + 16 ADP + 16 phosphate." [EC:1.18.6.1]


id: GO:0016737
name: oxidoreductase activity, acting on reduced flavodoxin as donor
namespace: molecular_function
def:
  "Catalysis of an oxidation-reduction (redox) reaction in which reduced flavodoxin acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]


id: GO:0016738
name: oxidoreductase activity, acting on reduced flavodoxin as donor, dinitrogen as acceptor
namespace: molecular_function
def:
  "Catalysis of an oxidation-reduction (redox) reaction in which reduced flavodoxin acts as a hydrogen or electron donor and reduces dinitrogen." [GOC:jl]


id: GO:0016740
name: transferase activity
namespace: molecular_function
def:
  "Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732]


id: GO:0016741
name: transferase activity, transferring one-carbon groups
namespace: molecular_function
def:
  "Catalysis of the transfer of a one-carbon group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]


id: GO:0016742
name: hydroxymethyl-, formyl- and related transferase activity
namespace: molecular_function
def:
  "Catalysis of the transfer of a hydroxymethyl- or formyl group from one compound (donor) to another (acceptor)." [EC:2.1.2, GOC:mah]


id: GO:0016743
name: carboxyl- or carbamoyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the transfer of a carboxyl- or carbamoyl group from one compound (donor) to another (acceptor)." [GOC:jl]


id: GO:0016744
name: transferase activity, transferring aldehyde or ketonic groups
namespace: molecular_function
def:
  "Catalysis of the transfer of an aldehyde or ketonic group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]


id: GO:0016746
name: transferase activity, transferring acyl groups
namespace: molecular_function
def:
  "Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]


id: GO:0016747
name: transferase activity, transferring acyl groups other than amino-acyl groups
namespace: molecular_function
def:
  "Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor)." [GOC:jl]


id: GO:0016748
name: succinyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the transfer of a succinyl (3-carboxypropanoyl) group to an acceptor molecule." [GOC:ai]


id: GO:0016749
name: N-succinyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the transfer of a succinyl group to a nitrogen atom on the acceptor molecule." [GOC:ai]


id: GO:0016750
name: O-succinyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the transfer of a succinyl group to an oxygen atom on the acceptor molecule." [GOC:ai]


id: GO:0016753
name: O-sinapoyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the transfer of a sinapoyl group to an oxygen atom on the acceptor molecule." [GOC:ai]


id: GO:0016754
name: sinapoylglucose-malate O-sinapoyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: (S)-malate + 1-O-sinapoyl-beta-D-glucose = D-glucose + sinapoyl (S)-malate." [EC:2.3.1.92, RHEA:12628]


id: GO:0016755
name: transferase activity, transferring amino-acyl groups
namespace: molecular_function
def:
  "Catalysis of the transfer of an amino-acyl group from one compound (donor) to another (acceptor)." [GOC:jl]


id: GO:0016756
name: glutathione gamma-glutamylcysteinyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: glutathione + Glu(-Cys)(n)-Gly = Gly + Glu(-Cys)(n+1)-Gly." [EC:2.3.2.15]


id: GO:0016757
name: transferase activity, transferring glycosyl groups
namespace: molecular_function
def:
  "Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]


id: GO:0016758
name: transferase activity, transferring hexosyl groups
namespace: molecular_function
def:
  "Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor)." [GOC:jl]


id: GO:0016759
name: cellulose synthase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: nucleoside-disphosphate-glucose + ((1,4)-beta-D-glucosyl)(n) = nucleoside-disphosphate + ((1,4)-beta-D-glucosyl)(n+1)." [EC:2.4.1.12, EC:2.4.1.29]


id: GO:0016760
name: cellulose synthase (UDP-forming) activity
namespace: molecular_function
def:
  "Catalysis of the reaction: UDP-glucose + ((1,4)-beta-D-glucosyl)(n) = UDP + ((1,4)-beta-D-glucosyl)(n+1)." [EC:2.4.1.12]


id: GO:0016761
name: cellulose synthase (GDP-forming) activity
namespace: molecular_function
def:
  "Catalysis of the reaction: GDP-glucose + ((1,4)-beta-D-glucosyl)(n) = GDP + ((1,4)-beta-D-glucosyl)(n+1)." [EC:2.4.1.29]


id: GO:0016762
name: xyloglucan:xyloglucosyl transferase activity
namespace: molecular_function
def:
  "Catalysis of the cleavage of a beta-(1->4) bond in the backbone of a xyloglucan and transfers the xyloglucanyl segment on to O-4 of the non-reducing terminal glucose residue of an acceptor, which can be a xyloglucan or an oligosaccharide of xyloglucan." [EC:2.4.1.207]


id: GO:0016763
name: transferase activity, transferring pentosyl groups
namespace: molecular_function
def:
  "Catalysis of the transfer of a pentosyl group from one compound (donor) to another (acceptor)." [GOC:jl]


id: GO:0016764
name: obsolete transferase activity, transferring other glycosyl groups
namespace: molecular_function
def:
  "OBSOLETE. Catalysis of the transfer of a glycosyl group, other than hexosyl or pentosyl, from one compound (donor) to another (acceptor)." [GOC:jl]


id: GO:0016765
name: transferase activity, transferring alkyl or aryl (other than methyl) groups
namespace: molecular_function
def:
  "Catalysis of the transfer of an alkyl or aryl (but not methyl) group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]


id: GO:0016767
name: geranylgeranyl-diphosphate geranylgeranyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 2 geranylgeranyl diphosphate = diphosphate + prephytoene diphosphate." [EC:2.5.1.32]


id: GO:0016768
name: spermine synthase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: S-adenosylmethioninamine + spermidine = 5'-methylthioadenosine + spermine." [EC:2.5.1.22]


id: GO:0016769
name: transferase activity, transferring nitrogenous groups
namespace: molecular_function
def:
  "Catalysis of the transfer of a nitrogenous group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]


id: GO:0016771
name: obsolete transferase activity, transferring other nitrogenous groups
namespace: molecular_function
def:
  "OBSOLETE. Catalysis of the transfer of a nitrogenous group, other than amino, amidino or oxime, from one compound (donor) to another (acceptor)." [GOC:ai]


id: GO:0016772
name: transferase activity, transferring phosphorus-containing groups
namespace: molecular_function
def:
  "Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]


id: GO:0016773
name: phosphotransferase activity, alcohol group as acceptor
namespace: molecular_function
def:
  "Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor)." [GOC:jl]


id: GO:0016774
name: phosphotransferase activity, carboxyl group as acceptor
namespace: molecular_function
def:
  "Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to a carboxyl group (acceptor)." [GOC:jl]


id: GO:0016775
name: phosphotransferase activity, nitrogenous group as acceptor
namespace: molecular_function
def:
  "Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to a nitrogenous group (acceptor)." [GOC:jl]


id: GO:0016776
name: phosphotransferase activity, phosphate group as acceptor
namespace: molecular_function
def:
  "Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to a phosphate group (acceptor)." [GOC:jl]


id: GO:0016778
name: diphosphotransferase activity
namespace: molecular_function
def:
  "Catalysis of the transfer of a diphosphate group from one compound (donor) to a another (acceptor)." [GOC:jl, http://www.chem.qmul.ac.uk/iubmb/enzyme/EC2/intro.html]


id: GO:0016780
name: phosphotransferase activity, for other substituted phosphate groups
namespace: molecular_function
def:
  "Catalysis of the transfer of a substituted phosphate group, other than diphosphate or nucleotidyl residues, from one compound (donor) to a another (acceptor)." [GOC:jl, http://www.chem.qmul.ac.uk/iubmb/enzyme/EC2/intro.html]


id: GO:0016781
name: phosphotransferase activity, paired acceptors
namespace: molecular_function
def:
  "Catalysis of the transfer of two phosphate groups from a donor, such as ATP, to two different acceptors." [GOC:jl, http://www.chem.qmul.ac.uk/iubmb/enzyme/EC2/intro.html]


id: GO:0016782
name: transferase activity, transferring sulfur-containing groups
namespace: molecular_function
def:
  "Catalysis of the transfer of a sulfur-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]


id: GO:0016783
name: sulfurtransferase activity
namespace: molecular_function
def:
  "Catalysis of the transfer of sulfur atoms from one compound (donor) to another (acceptor)." [GOC:ai, ISBN:0721662544]


id: GO:0016785
name: transferase activity, transferring selenium-containing groups
namespace: molecular_function
def:
  "Catalysis of the transfer of a selenium-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732]


id: GO:0016787
name: hydrolase activity
namespace: molecular_function
def:
  "Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732]


id: GO:0016790
name: thiolester hydrolase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: RCO-SR' + H2O = RCOOH + HSR'. This reaction is the hydrolysis of a thiolester bond, an ester formed from a carboxylic acid and a thiol (i.e., RCO-SR'), such as that found in acetyl-coenzyme A." [http://www.onelook.com]


id: GO:0016791
name: phosphatase activity
namespace: molecular_function
def:
  "Catalysis of the hydrolysis of phosphoric monoesters, releasing inorganic phosphate." [EC:3.1.3, EC:3.1.3.41, GOC:curators, GOC:pg]


id: GO:0016793
name: triphosphoric monoester hydrolase activity
namespace: molecular_function
def:
  "Catalysis of the hydrolysis of a triphosphoester to give a triphosphate group and a free hydroxyl group." [GOC:ai]


id: GO:0016794
name: diphosphoric monoester hydrolase activity
namespace: molecular_function
def:
  "Catalysis of the hydrolysis of a diphosphoester to give a diphosphate group and a free hydroxyl group." [GOC:ai]


id: GO:0016796
namespace: molecular_function
name:
  exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters

def:
  "Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' or 5' end to yield 5' phosphomonoesters." [GOC:mah]


id: GO:0016797
namespace: molecular_function
name:
  exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters

def:
  "Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' or 5' end to yield 3' phosphomonoesters." [GOC:mah]


id: GO:0016801
name: hydrolase activity, acting on ether bonds
namespace: molecular_function
def:
  "Catalysis of the hydrolysis of any ether or thioether bond, -O- or -S- respectively." [GOC:ai, GOC:jl]


id: GO:0016806
name: obsolete dipeptidyl-peptidase and tripeptidyl-peptidase activity
namespace: molecular_function
def:
  "OBSOLETE. Catalysis of the hydrolysis of N-terminal di- or tripeptides from a polypeptide chain." [GOC:ai]


id: GO:0016807
name: cysteine-type carboxypeptidase activity
namespace: molecular_function
def:
  "Catalysis of the hydrolysis of C-terminal peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CARBOXYPEPTIDASE, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE]


id: GO:0016810
name: hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
namespace: molecular_function
def:
  "Catalysis of the hydrolysis of any carbon-nitrogen bond, C-N, with the exception of peptide bonds." [GOC:jl]


id: GO:0016813
name: hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines
namespace: molecular_function
def:
  "Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a linear amidine, a compound of the form R-C(=NH)-NH2." [ISBN:0198506732]


id: GO:0016814
name: hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines
namespace: molecular_function
def:
  "Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a cyclic amidine, a compound of the form R-C(=NH)-NH2." [ISBN:0198506732]


id: GO:0016815
name: hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in nitriles
namespace: molecular_function
def:
  "Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a nitrile, a compound containing the cyano radical, -CN." [http://www.onelook.com/]


id: GO:0016816
name: obsolete hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in other compounds
namespace: molecular_function
def:
  "OBSOLETE. Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in substances other than amides, amidines and nitriles." [GOC:ai]


id: GO:0016819
name: hydrolase activity, acting on acid anhydrides, in sulfonyl-containing anhydrides
namespace: molecular_function
def:
  "Catalysis of the hydrolysis of any acid anhydride which contains a sulfonyl group, -SO2-." [GOC:ai]


id: GO:0016820
name: hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances
namespace: molecular_function
def:
  "Catalysis of the hydrolysis of an acid anhydride to directly drive the transport of a substance across a membrane." [GOC:mah]


id: GO:0016821
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah]
name:
  obsolete hydrolase activity, acting on acid anhydrides, involved in cellular and subcellular movement


id: GO:0016823
name: hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances
namespace: molecular_function
def:
  "Catalysis of the hydrolysis of any acid carbon-carbon bond in a ketonic substance, a substance containing a keto (C=O) group." [GOC:ai]


id: GO:0016829
name: lyase activity
namespace: molecular_function
def:
  "Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring." [EC:4.-.-.-, ISBN:0198547684]


id: GO:0016830
name: carbon-carbon lyase activity
namespace: molecular_function
def:
  "Catalysis of the cleavage of C-C bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond." [GOC:jl]


id: GO:0016831
name: carboxy-lyase activity
namespace: molecular_function
def:
  "Catalysis of the nonhydrolytic addition or removal of a carboxyl group to or from a compound." [http://www.mercksource.com/]


id: GO:0016832
name: aldehyde-lyase activity
namespace: molecular_function
def:
  "Catalysis of the cleavage of a C-C bond in a molecule containing a hydroxyl group and a carbonyl group to form two smaller molecules, each being an aldehyde or a ketone." [http://www.mercksource.com/]


id: GO:0016833
name: oxo-acid-lyase activity
namespace: molecular_function
def:
  "Catalysis of the cleavage of a C-C bond by other means than by hydrolysis or oxidation, of a 3-hydroxy acid." [EC:4.1.3, GOC:jl]


id: GO:0016834
name: obsolete other carbon-carbon lyase activity
namespace: molecular_function
def:
  "OBSOLETE. A grouping term for carbon-carbon lyases that cannot be more accurately categorized." [GOC:ai]


id: GO:0016837
name: carbon-oxygen lyase activity, acting on polysaccharides
namespace: molecular_function
def:
  "Catalysis of the cleavage of a carbon-oxygen bond by the elimination of an alcohol from a polysaccharide." [EC:4.2.-.-]


id: GO:0016839
name: obsolete other carbon-oxygen lyase activity
namespace: molecular_function
def:
  "OBSOLETE. Catalysis of the cleavage of a carbon-oxygen bond. Enzymes with this activity are 'miscellaneous' carbon-oxygen lyases that cannot be grouped into one of the specific subclasses of the carbon-oxygen lyases." [GOC:krc]


id: GO:0016840
name: carbon-nitrogen lyase activity
namespace: molecular_function
def:
  "Catalysis of the release of ammonia or one of its derivatives, with the formation of a double bond or ring. Enzymes with this activity may catalyze the actual elimination of the ammonia, amine or amide, e.g. CH-CH(-NH-R) = C=CH- + NH2-R. Others, however, catalyze elimination of another component, e.g. water, which is followed by spontaneous reactions that lead to breakage of the C-N bond, e.g. L-serine ammonia-lyase (EC:4.3.1.17), so that the overall reaction is C(-OH)-CH(-NH2) = CH2-CO- + NH3, i.e. an elimination with rearrangement. The sub-subclasses of EC:4.3 are the ammonia-lyases (EC:4.3.1), lyases acting on amides, amidines, etc. (EC:4.3.2), the amine-lyases (EC:4.3.3), and other carbon-nitrogen lyases (EC:4.3.99)." [EC:4.3.-.-]


id: GO:0016841
name: ammonia-lyase activity
namespace: molecular_function
def:
  "Catalysis of the release of ammonia by the cleavage of a carbon-nitrogen bond or the reverse reaction with ammonia as a substrate." [EC:4.3.-.-, GOC:krc]


id: GO:0016842
name: amidine-lyase activity
namespace: molecular_function
def:
  "Catalysis of the release of amides or amidines by the cleavage of a carbon-nitrogen bond or the reverse reaction with an amide or amidine as a substrate." [EC:4.3.-.-, GOC:krc]


id: GO:0016843
name: amine-lyase activity
namespace: molecular_function
def:
  "Catalysis of the release of amides by the cleavage of a carbon-nitrogen bond or the reverse reaction with an amine as a substrate." [EC:4.3.-.-, GOC:krc]


id: GO:0016844
name: strictosidine synthase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 3alpha(S)-strictosidine + H(2)O = secologanin + tryptamine." [EC:4.3.3.2, RHEA:15016]


id: GO:0016845
name: obsolete other carbon-nitrogen lyase activity
namespace: molecular_function
def:
  "OBSOLETE. Catalysis of the cleavage of a carbon-nitrogen bond. Enzymes with this activity are 'miscellaneous' carbon-nitrogen lyases that cannot be grouped into one of the specific subclasses of the carbon-nitrogen lyases." [GOC:krc]


id: GO:0016847
name: 1-aminocyclopropane-1-carboxylate synthase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: S-adenosyl-L-methionine(1+) = 1-aminocyclopropane-1-carboxylate + S-methyl-5'-thioadenosine + H(+)." [EC:4.4.1.14, RHEA:21747]


id: GO:0016849
name: phosphorus-oxygen lyase activity
namespace: molecular_function
def:
  "Catalysis of the cleavage of a phosphorus-oxygen bond by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond." [GOC:jl]


id: GO:0016851
name: magnesium chelatase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: ATP + H(2)O + Mg(2+) + protoporphyrin IX = ADP + 2 H(+) + magnesium protoporphyrin IX + phosphate." [EC:6.6.1.1, RHEA:13964]


id: GO:0016852
name: sirohydrochlorin cobaltochelatase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: sirohydrochlorin + Co2+ = cobalt-sirohydrochlorin + 2 H+." [EC:4.99.1.3]


id: GO:0016853
name: isomerase activity
namespace: molecular_function
def:
  "Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5." [ISBN:0198506732]


id: GO:0016854
name: racemase and epimerase activity
namespace: molecular_function
def:
  "Catalysis of a reaction that alters the configuration of one or more chiral centers in a molecule." [GOC:mah, ISBN:0198506732]


id: GO:0016855
name: racemase and epimerase activity, acting on amino acids and derivatives
namespace: molecular_function
def:
  "Catalysis of a reaction that alters the configuration of one or more chiral centers in an amino acid." [GOC:mah]


id: GO:0016856
name: racemase and epimerase activity, acting on hydroxy acids and derivatives
namespace: molecular_function
def:
  "Catalysis of a reaction that alters the configuration of one or more chiral centers in a hydroxy acid molecule." [GOC:mah]


id: GO:0016857
name: racemase and epimerase activity, acting on carbohydrates and derivatives
namespace: molecular_function
def:
  "Catalysis of a reaction that alters the configuration of one or more chiral centers in a carbohydrate molecule." [GOC:mah]


id: GO:0016858
name: obsolete racemase and epimerase activity, acting on other compounds
namespace: molecular_function
def:
  "OBSOLETE. Racemase and epimerase activity on compounds other than amino acids, hydroxy acids, carbohydrates or their derivatives." [GOC:ai]


id: GO:0016859
name: cis-trans isomerase activity
namespace: molecular_function
def:
  "Catalysis of a reaction that interconverts cis and trans isomers. Atoms or groups are termed cis or trans to one another when they lie respectively on the same or on opposite sides of a reference plane identifiable as common among stereoisomers." [GOC:mah, ISBN:0198506732]


id: GO:0016860
name: intramolecular oxidoreductase activity
namespace: molecular_function
def:
  "Catalysis of an oxidation-reduction (redox) reaction in which the hydrogen donor and acceptor are the same molecule, and no oxidized product appears." [EC:5.3.-.-]


id: GO:0016861
name: intramolecular oxidoreductase activity, interconverting aldoses and ketoses
namespace: molecular_function
def:
  "Catalysis of an oxidation-reduction (redox) reaction in which the hydrogen donor and acceptor, which is an aldose or a ketose, are the same molecule, and no oxidized product appears." [GOC:jl]


id: GO:0016862
name: intramolecular oxidoreductase activity, interconverting keto- and enol-groups
namespace: molecular_function
def:
  "Catalysis of an oxidation-reduction (redox) reaction in which the hydrogen donor and acceptor, which is a keto- or an enol-group, are the same molecule, and no oxidized product appears." [GOC:jl]


id: GO:0016863
name: intramolecular oxidoreductase activity, transposing C=C bonds
namespace: molecular_function
def:
  "Catalysis of an oxidation-reduction (redox) reaction in which the hydrogen donor and acceptor are the same molecule, one or more carbon-carbon double bonds in the molecule are rearranged, and no oxidized product appears." [EC:5.3.3, GOC:mah]


id: GO:0016864
name: intramolecular oxidoreductase activity, transposing S-S bonds
namespace: molecular_function
def:
  "Catalysis of an oxidation-reduction (redox) reaction in which the hydrogen donor and acceptor are the same molecule, one or more sulfur-sulfur bonds in the molecule are rearranged, and no oxidized product appears." [EC:5.3.4, GOC:mah]


id: GO:0016865
name: obsolete intramolecular oxidoreductase activity, other intramolecular oxidoreductases
namespace: molecular_function
def:
  "OBSOLETE. A grouping term for intramolecular oxidoreductases that cannot be more accurately categorized." [GOC:ai]


id: GO:0016866
name: intramolecular transferase activity
namespace: molecular_function
def:
  "Catalysis of the transfer of a functional group from one position to another within a single molecule." [GOC:mah]


id: GO:0016867
name: intramolecular transferase activity, transferring acyl groups
namespace: molecular_function
def:
  "Catalysis of the transfer of an acyl group from one position to another within a single molecule." [GOC:mah]


id: GO:0016868
name: intramolecular transferase activity, phosphotransferases
namespace: molecular_function
def:
  "Catalysis of the transfer of a phosphate group from one position to another within a single molecule." [GOC:mah]


id: GO:0016869
name: intramolecular transferase activity, transferring amino groups
namespace: molecular_function
def:
  "Catalysis of the transfer of an amino group from one position to another within a single molecule." [GOC:mah]


id: GO:0016870
name: obsolete intramolecular transferase activity, transferring other groups
namespace: molecular_function
def:
  "OBSOLETE. A grouping term for intramolecular transferases that cannot be more accurately categorized." [GOC:ai]


id: GO:0016872
name: intramolecular lyase activity
namespace: molecular_function
def:
  "The catalysis of certain rearrangements of a molecule to break or form a ring." [GOC:jl, http://www.mercksource.com/]


id: GO:0016874
name: ligase activity
namespace: molecular_function
def:
  "Catalysis of the joining of two substances, or two groups within a single molecule, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [EC:6, GOC:mah]


id: GO:0016875
name: ligase activity, forming carbon-oxygen bonds
namespace: molecular_function
def:
  "Catalysis of the joining of two molecules via a carbon-oxygen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [EC:6.1, GOC:mah]


id: GO:0016876
name: ligase activity, forming aminoacyl-tRNA and related compounds
namespace: molecular_function
def:
  "Catalysis of the joining of an amino acid and a nucleic acid (usually tRNA) or poly(ribitol phosphate), with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate. The reaction forms an aminoacyl-tRNA or a related compound." [EC:6.1.1, GOC:mah]


id: GO:0016877
name: ligase activity, forming carbon-sulfur bonds
namespace: molecular_function
def:
  "Catalysis of the joining of two molecules via a carbon-sulfur bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [EC:6.2, GOC:mah]


id: GO:0016878
name: acid-thiol ligase activity
namespace: molecular_function
def:
  "Catalysis of the joining of an acid and a thiol via a carbon-sulfur bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [EC:6.2.1, GOC:mah]


id: GO:0016879
name: ligase activity, forming carbon-nitrogen bonds
namespace: molecular_function
def:
  "Catalysis of the joining of two molecules, or two groups within a single molecule, via a carbon-nitrogen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [EC:6.3, GOC:mah]


id: GO:0016880
name: acid-ammonia (or amide) ligase activity
namespace: molecular_function
def:
  "Catalysis of the ligation of an acid to ammonia (NH3) or an amide via a carbon-nitrogen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [GOC:jl, GOC:mah]


id: GO:0016881
name: acid-amino acid ligase activity
namespace: molecular_function
def:
  "Catalysis of the ligation of an acid to an amino acid via a carbon-nitrogen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [GOC:jl, GOC:mah]


id: GO:0016882
name: cyclo-ligase activity
namespace: molecular_function
def:
  "Catalysis of the joining of two groups within a single molecule via a carbon-nitrogen bond, forming heterocyclic ring, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [EC:6.3.3.1, EC:6.3.3.2, EC:6.3.3.4, GOC:jl, GOC:mah]


id: GO:0016883
name: obsolete other carbon-nitrogen ligase activity
namespace: molecular_function
def:
  "OBSOLETE. A grouping term for carbon-nitrogen ligases that cannot be more accurately categorized." [GOC:ai]


id: GO:0016884
name: carbon-nitrogen ligase activity, with glutamine as amido-N-donor
namespace: molecular_function
def:
  "Catalysis of the transfer of the amide nitrogen of glutamine to a variety of substrates. GATases catalyze two separate reactions at two active sites, which are located either on a single polypeptide chain or on different subunits. In the glutaminase reaction, glutamine is hydrolyzed to glutamate and ammonia, which is added to an acceptor substrate in the synthase reaction." [PMID:12360532]


id: GO:0016885
name: ligase activity, forming carbon-carbon bonds
namespace: molecular_function
def:
  "Catalysis of the joining of two molecules via a carbon-carbon bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [EC:6.4, GOC:jl, GOC:mah]


id: GO:0016886
name: ligase activity, forming phosphoric ester bonds
namespace: molecular_function
def:
  "Catalysis of the joining of two molecules, or two groups within a single molecule, via a phosphoric ester bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [EC:6.5, GOC:mah]


id: GO:0016887
name: ATPase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction." [EC:3.6.1.3, GOC:jl]


id: GO:0016888
name: endodeoxyribonuclease activity, producing 5'-phosphomonoesters
namespace: molecular_function
def:
  "Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acids by creating internal breaks to yield 5'-phosphomonoesters." [GOC:ai]


id: GO:0016889
name: endodeoxyribonuclease activity, producing 3'-phosphomonoesters
namespace: molecular_function
def:
  "Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acids by creating internal breaks to yield 3'-phosphomonoesters." [GOC:ai]


id: GO:0016890
name: site-specific endodeoxyribonuclease activity, specific for altered base
namespace: molecular_function
def:
  "Catalysis of the hydrolysis of ester linkages at specific sites within a deoxyribonucleic acid molecule by creating internal breaks." [GOC:jl]


id: GO:0016891
name: endoribonuclease activity, producing 5'-phosphomonoesters
namespace: molecular_function
def:
  "Catalysis of the hydrolysis of ester linkages within ribonucleic acids by creating internal breaks to yield 5'-phosphomonoesters." [GOC:ai]


id: GO:0016892
name: endoribonuclease activity, producing 3'-phosphomonoesters
namespace: molecular_function
def:
  "Catalysis of the hydrolysis of ester linkages within ribonucleic acids by creating internal breaks to yield 3'-phosphomonoesters." [GOC:ai]


id: GO:0016893
namespace: molecular_function
name:
  endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters

def:
  "Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks to yield 5'-phosphomonoesters." [GOC:mah]


id: GO:0016894
namespace: molecular_function
name:
  endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters

def:
  "Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks to yield 3'-phosphomonoesters." [GOC:mah]


id: GO:0016895
name: exodeoxyribonuclease activity, producing 5'-phosphomonoesters
namespace: molecular_function
def:
  "Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acids by removing nucleotide residues from the 3' or 5' end to yield 5' phosphomonoesters." [GOC:ai]


id: GO:0016896
name: exoribonuclease activity, producing 5'-phosphomonoesters
namespace: molecular_function
def:
  "Catalysis of the hydrolysis of ester linkages within ribonucleic acids by removing nucleotide residues from the 3' or 5' end to yield 5' phosphomonoesters." [GOC:ai]


id: GO:0016897
name: exoribonuclease activity, producing 3'-phosphomonoesters
namespace: molecular_function
def:
  "Catalysis of the hydrolysis of ester linkages within ribonucleic acids by removing nucleotide residues from the 3' or 5' end to yield 3' phosphomonoesters." [GOC:ai]


id: GO:0016898
name: oxidoreductase activity, acting on the CH-OH group of donors, cytochrome as acceptor
namespace: molecular_function
def:
  "Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces a cytochrome molecule." [GOC:ai]


id: GO:0016899
name: oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor
namespace: molecular_function
def:
  "Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces an oxygen molecule." [GOC:ai]


id: GO:0016900
name: oxidoreductase activity, acting on the CH-OH group of donors, disulfide as acceptor
namespace: molecular_function
def:
  "Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces a disulfide molecule." [GOC:ai]


id: GO:0016901
namespace: molecular_function
name:
  oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor

def:
  "Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces a quinone or a similar acceptor molecule." [GOC:ai]


id: GO:0016902
name: obsolete oxidoreductase activity, acting on the CH-OH group of donors, other acceptors
namespace: molecular_function
def:
  "OBSOLETE. Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces an acceptor other than a cytochrome, disulfide, NAD, NADP, oxygen or a quinone or similar compound." [GOC:ai]


id: GO:0016903
name: oxidoreductase activity, acting on the aldehyde or oxo group of donors
namespace: molecular_function
def:
  "Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai]


id: GO:0016905
name: myosin heavy chain kinase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: ATP + myosin-heavy-chain = ADP + myosin-heavy-chain phosphate." [EC:2.7.11.7]


id: GO:0016907
name: G-protein coupled acetylcholine receptor activity
namespace: molecular_function
def:
  "Combining with acetylcholine and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, GOC:fj, GOC:mah]


id: GO:0016909
name: SAP kinase activity
namespace: molecular_function
def:
  "Catalysis of the phosphorylation of proteins. A family of protein kinases that perform a crucial step in relaying signals from the plasma membrane to the nucleus. Strongly activated by stress signals such as heat or osmotic shock, DNA-damaging agents, inhibitors of protein synthesis and pro-inflammatory cytokines." [GOC:ma]


id: GO:0016913
name: follicle-stimulating hormone activity
namespace: molecular_function
def:
  "The action characteristic of follicle-stimulating hormone (FSH), a gonadotrophic glycoprotein hormone secreted, in mammals, by the anterior pituitary gland. Upon receptor binding, FSH stimulates growth of Graafian follicles in the ovaries in females, and stimulates the epithelium of the seminiferous tubules to increase spermatogenesis." [ISBN:0198547684]


id: GO:0016914
name: follicle-stimulating hormone complex
namespace: cellular_component
def:
  "A gonadotrophic glycoprotein hormone secreted, in mammals, by the anterior pituitary gland; consists of alpha and beta subunits, the latter of which confers hormonal specificity." [ISBN:0198547684]


id: GO:0016915
name: obsolete activin
namespace: molecular_function
def:
  "OBSOLETE. A nonsteroidal regulator, composed of two covalently linked beta subunits, that is synthesized in the pituitary gland and gonads and stimulates the secretion of follicle-stimulating hormone." [ISBN:0198506732, ISBN:0721662544]


id: GO:0016916
name: obsolete inhibin
namespace: molecular_function
def:
  "OBSOLETE. Either of two glycoproteins (designated A and B), secreted by the gonads and present in seminal plasma and follicular fluid, that inhibit pituitary production of follicle-stimulating hormone." [ISBN:0198506732, ISBN:0721662544]


id: GO:0016917
name: GABA receptor activity
namespace: molecular_function
def:
  "Combining with gamma-aminobutyric acid (GABA), and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. (GABA, 4-aminobutyrate) is an amino acid which acts as a neurotransmitter in some organisms." [GOC:jl, GOC:signaling, PMID:10637650]


id: GO:0016918
name: retinal binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with retinal, one of the forms of vitamin A. Retinal plays an important role in the visual process in most vertebrates, combining with opsins to form visual pigments in the retina." [CHEBI:15035, GOC:curators, ISBN:0198506732]


id: GO:0016919
name: obsolete nardilysin activity
namespace: molecular_function
def:
  "OBSOLETE. Catalysis of the hydrolysis of polypeptides, preferably at the first bond of Xaa-Arg-Lys, and less commonly at the first bond of Arg-Arg-Xaa, in which Xaa is not Arg or Lys." [EC:3.4.24.61]


id: GO:0016920
name: pyroglutamyl-peptidase activity
namespace: molecular_function
def:
  "Catalysis of the release of the N-terminal pyroglutamyl group from a peptide or protein." [EC:3.4.19.3, EC:3.4.19.6, GOC:mah]


id: GO:0016921
name: obsolete pyroglutamyl-peptidase II activity
namespace: molecular_function
def:
  "OBSOLETE. Catalysis of the release of the N-terminal pyroglutamyl group from pGlu-His-Xaa tripeptides and pGlu-His-Xaa-Gly tetrapeptides." [EC:3.4.19.6]


id: GO:0016922
name: ligand-dependent nuclear receptor binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently, in a ligand dependent manner, with a nuclear receptor protein." [GOC:mah, PMID:7776974]


id: GO:0016925
name: protein sumoylation
namespace: biological_process
def:
  "The process in which a SUMO protein (small ubiquitin-related modifier) is conjugated to a target protein via an isopeptide bond between the carboxyl terminus of SUMO with an epsilon-amino group of a lysine residue of the target protein." [GOC:jl, PMID:11265250]


id: GO:0016926
name: protein desumoylation
namespace: biological_process
def:
  "The process in which a SUMO protein (small ubiquitin-related modifier) is cleaved from its target protein." [GOC:jl, PMID:11265250]


id: GO:0016929
name: SUMO-specific protease activity
namespace: molecular_function
def:
  "Catalysis of the hydrolysis of SUMO, a small ubiquitin-related modifier, from previously sumoylated substrates." [GOC:rn, PMID:10094048, PMID:11031248, PMID:11265250]


id: GO:0016933
name: extracellular-glycine-gated ion channel activity
namespace: molecular_function
def:
  "Enables the transmembrane transfer of an ion by a channel that opens when extracellular glycine has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729]


id: GO:0016934
name: extracellular-glycine-gated chloride channel activity
namespace: molecular_function
def:
  "Enables the transmembrane transfer of a chloride ion by a channel that opens when extracellular glycine has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729]


id: GO:0016935
name: glycine-gated chloride channel complex
namespace: cellular_component
def:
  "A protein complex that forms a transmembrane channel through which chloride ions may pass in response to glycine binding to the channel complex or one of its constituent parts." [GOC:mah]


id: GO:0016936
name: galactoside binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with any glycoside in which the sugar group is galactose." [CHEBI:24163, GOC:jl, ISBN:0198506732]


id: GO:0016937
name: short-branched-chain-acyl-CoA dehydrogenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor, where the acyl group is a short branched chain fatty acid residue." [GOC:mah]


id: GO:0016938
name: kinesin I complex
namespace: cellular_component
def:
  "A complex of two kinesin heavy chains and two kinesin light chains." [http://www.csfic.mi.cnr.it/centro/lines/8/ric.html]


id: GO:0016939
name: kinesin II complex
namespace: cellular_component
def:
  "A complex consisting of two distinct motor subunits that form a heterodimer complexed with a third non-motor accessory subunit, the kinesin associated protein or KAP; the KIF3 heterodimer interacts via its C-terminal portion with KAP, which is thought to regulate the binding of the motor to cargo membranes." [http://www.csfic.mi.cnr.it/centro/lines/8/ric.html]


id: GO:0016941
name: natriuretic peptide receptor activity
namespace: molecular_function
def:
  "Combining with a natriuretic peptide and transmitting the signal to initiate a change in cell activity." [GOC:mah, GOC:signaling]


id: GO:0016942
name: insulin-like growth factor binding protein complex
namespace: cellular_component
def:
  "A complex of proteins which includes the insulin-like growth factor (IGF) and a number of IGF-binding proteins. The complex plays a role in growth and development." [GOC:jl]


id: GO:0016943
name: obsolete RNA polymerase I transcription elongation factor activity
namespace: molecular_function
def:
  "OBSOLETE. Any activity that modulates the rate of transcription elongation, the addition of ribonucleotides to an RNA molecule catalyzed by RNA polymerase I following transcription initiation." [GOC:mah]


id: GO:0016944
name: obsolete RNA polymerase II transcription elongation factor activity
namespace: molecular_function
def:
  "OBSOLETE. Any activity that modulates the rate of transcription elongation, the addition of ribonucleotides to an RNA molecule catalyzed by RNA polymerase II following transcription initiation." [GOC:mah]


id: GO:0016945
name: obsolete RNA polymerase III transcription elongation factor activity
namespace: molecular_function
def:
  "OBSOLETE. Any activity that modulates the rate of transcription elongation, the addition of ribonucleotides to an RNA molecule catalyzed by RNA polymerase III following transcription initiation." [GOC:mah]


id: GO:0016946
name: obsolete cathepsin F activity
namespace: molecular_function
def:
  "OBSOLETE. Catalysis of the hydrolysis of peptide bonds. Cleavage of substrates with Phe and Leu in P2." [EC:3.4.22.41]


id: GO:0016963
name: obsolete alpha-2 macroglobulin receptor-associated protein activity
namespace: molecular_function
def:
  "OBSOLETE. Interaction with the alpha-2 macroglobulin receptor and glycoprotein gp330 forming a complex with the alpha-2 macroglobulin receptor light and heavy chains." [GOC:curators]


id: GO:0016964
name: alpha-2 macroglobulin receptor activity
namespace: molecular_function
def:
  "Combining with alpha-2 macroglobulin and delivering alpha-2 macroglobulin into the cell via receptor-mediated endocytosis." [GOC:bf, GOC:ma, PMID:6188403]


id: GO:0016966
name: nitric oxide reductase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: H(2)O + 2 ferricytochrome c + nitrous oxide = 2 H(+) + 2 ferrocytochrome c + 2 nitric oxide." [EC:1.7.2.5]


id: GO:0016969
name: obsolete hemerythrin
namespace: molecular_function
def:
  "OBSOLETE. An oxygen carrier found in a few groups of invertebrates, e.g. sipunculid worms, certain molluscs, and crustaceans." [GOC:ai, ISBN:0198506732]


id: GO:0016970
name: obsolete hemocyanin
namespace: molecular_function
def:
  "OBSOLETE. A blue, copper-containing oxygen carrier present in many molluscs and arthropods." [GOC:ai, ISBN:0198506732]


id: GO:0016975
name: obsolete alpha-2 macroglobulin
namespace: molecular_function
def:
  "OBSOLETE. Inhibition of proteinase by a mechanism involving a bait region which contains specific sites, cleavage of which induces a conformational change that results in trapping of the proteinase; following cleavage in the bait region a thiolester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase; subsequently epsilon-amino groups of the proteinase react with thiolester linkages in the inhibitor to form stable amide links; the entrapped proteinase can now only act on low molecular mass substrates." [ISBN:0198547684]


id: GO:0016977
name: chitosanase activity
namespace: molecular_function
def:
  "Catalysis of the endohydrolysis of beta-1,4-linkages between N-acetyl-D-glucosamine and D-glucosamine residues in a partly acetylated chitosan." [EC:3.2.1.132]


id: GO:0016979
name: lipoate-protein ligase activity
namespace: molecular_function
def:
  "Catalysis of the formation of carbon-nitrogen bonds between lipoate (5-(1,2-dithiolan-3-yl)pentanoate) and a protein." [EC:6.3.4.-]


id: GO:0016984
name: ribulose-bisphosphate carboxylase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: D-ribulose 1,5-bisphosphate + CO2 + H2O = 2 3-phospho-D-glycerate." [EC:4.1.1.39]


id: GO:0016985
name: mannan endo-1,4-beta-mannosidase activity
namespace: molecular_function
def:
  "Catalysis of the random hydrolysis of (1->4)-beta-D-mannosidic linkages in mannans, galactomannans, glucomannans, and galactoglucomannans." [EC:3.2.1.78]


id: GO:0016987
name: sigma factor activity
namespace: molecular_function
def:
  "A sigma factor is the promoter specificity subunit of eubacterial-type multisubunit RNA polymerases, those whose core subunit composition is often described as alpha(2)-beta-beta-prime. (This type of multisubunit RNA polymerase complex is known to be found in eubacteria and plant plastids). Although sigma does not bind DNA on its own, when combined with the core to form the holoenzyme, this binds specifically to promoter sequences, with the sigma factor making sequence specific contacts with the promoter elements. The sigma subunit is released from the elongating form of the polymerase and is thus free to act catalytically for multiple RNA polymerase core enzymes." [GOC:krc, GOC:txnOH]


id: GO:0016988
name: obsolete transcription initiation factor antagonist activity
namespace: molecular_function
def:
  "OBSOLETE. The function of binding to a transcription factor and stopping, preventing or reducing the rate of its transcriptional activity." [GOC:jl]


id: GO:0016989
name: sigma factor antagonist activity
namespace: molecular_function
def:
  "The function of binding to a sigma factor and stopping, preventing or reducing the rate of its transcriptional activity." [GOC:jl, GOC:txnOH, Wikipedia:Anti-sigma_factors]


id: GO:0016992
name: lipoate synthase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: protein N6-(octanoyl)lysine + 2 sulfur + 2 S-adenosyl-L-methionine = protein N6-(lipoyl)lysine + 2 L-methionine + 2 5'-deoxyadenosyl." [EC:2.8.1.8, PMID:18307109]


id: GO:0016996
name: endo-alpha-(2,8)-sialidase activity
namespace: molecular_function
def:
  "Catalysis of the endohydrolysis of (2->8)-alpha-sialosyl linkages in oligo- or poly(sialic) acids." [EC:3.2.1.129]


id: GO:0016997
name: alpha-sialidase activity
namespace: molecular_function
def:
  "Catalysis of the hydrolysis of alpha-glycosidic linkages in oligo- or poly(sialic) acids." [GOC:mah]


id: GO:0016998
name: cell wall macromolecule catabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the breakdown of macromolecules that form part of a cell wall." [GOC:go_curators]


id: GO:0016999
name: antibiotic metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving an antibiotic, a substance produced by or derived from certain fungi, bacteria, and other organisms, that can destroy or inhibit the growth of other microorganisms." [GOC:cab2]


id: GO:0017000
name: antibiotic biosynthetic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of an antibiotic, a substance produced by or derived from certain fungi, bacteria, and other organisms, that can destroy or inhibit the growth of other microorganisms." [GOC:go_curators]


id: GO:0017001
name: antibiotic catabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the breakdown of antibiotic, a substance produced by or derived from certain fungi, bacteria, and other organisms, that can destroy or inhibit the growth of other microorganisms." [GOC:go_curators]


id: GO:0017002
name: activin-activated receptor activity
namespace: molecular_function
def:
  "Combining with activin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. Activin is one of two gonadal glycoproteins related to transforming growth factor beta." [GOC:mah, GOC:signaling, ISBN:0198506732]


id: GO:0017004
name: cytochrome complex assembly
namespace: biological_process
def:
  "The aggregation, arrangement and bonding together of a cytochrome complex. A cytochrome complex is a protein complex in which at least one of the proteins is a cytochrome, i.e. a heme-containing protein involved in catalysis of redox reactions." [GOC:jl, GOC:mah]


id: GO:0017005
name: 3'-tyrosyl-DNA phosphodiesterase activity
namespace: molecular_function
def:
  "Catalysis of the hydrolysis of 3'-phosphotyrosyl groups formed as covalent intermediates (in DNA backbone breakage) between DNA topoisomerase I and DNA." [PMID:10521354, PMID:16751265]


id: GO:0017014
name: protein nitrosylation
namespace: biological_process
def:
  "The covalent addition of a nitric oxide group to an amino acid within a protein." [GOC:ai, PMID:20972426]


id: GO:0017015
name: regulation of transforming growth factor beta receptor signaling pathway
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of activity of any TGF-beta receptor signaling pathway." [GOC:mah]


id: GO:0017016
name: Ras GTPase binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with any member of the Ras superfamily of monomeric GTPases." [GOC:mah]


id: GO:0017017
name: MAP kinase tyrosine/serine/threonine phosphatase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: MAP kinase serine/threonine/tyrosine phosphate + H2O = MAP kinase serine/threonine/tyrosine + phosphate." [GOC:mah, PMID:12184814]


id: GO:0017022
name: myosin binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with any part of a myosin complex; myosins are any of a superfamily of molecular motor proteins that bind to actin and use the energy of ATP hydrolysis to generate force and movement along actin filaments." [GOC:mah, http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html]


id: GO:0017023
name: myosin phosphatase complex
namespace: cellular_component
def:
  "An enzyme complex that catalyzes the removal of the phosphate group from phosphomyosin." [EC:3.1.3.16]


id: GO:0017024
name: myosin I binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with a class I myosin; myosin I heavy chains are single-headed, possess tails of various lengths, and do not self-associate into bipolar filaments." [GOC:bf, GOC:mah, http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html]


id: GO:0017025
name: TBP-class protein binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with a member of the class of TATA-binding proteins (TBP), including any of the TBP-related factors (TRFs)." [GOC:jl, GOC:txnOH, http://www.mblab.gla.ac.uk/, PMID:16858867]


id: GO:0017026
name: obsolete procollagen C-endopeptidase activity
namespace: molecular_function
def:
  "OBSOLETE. Catalysis of the cleavage of the C-terminal propeptide at Ala-Asp in type I and II procollagens and at Arg-Asp in type III." [EC:3.4.24.19]


id: GO:0017027
namespace: molecular_function
def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai]
name:
  obsolete transmembrane receptor protein serine/threonine kinase receptor-associated protein activity


id: GO:0017028
name: obsolete protein stabilization activity
namespace: molecular_function
def:
  "OBSOLETE. Strengthening of a bond between proteins. Proteins are large molecules composed of one or more chains of amino acids. The amino acids are joined in a specific order by peptide bonds." [GOC:jid, http://biotech.icmb.utexas.edu]


id: GO:0017032
name: potassium:amino acid symporter activity
namespace: molecular_function
def:
  "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: amino acid(out) + K+(out) = amino acid(in) + K+(in)." [GOC:ai]


id: GO:0017034
name: Rap guanyl-nucleotide exchange factor activity
namespace: molecular_function
def:
  "Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rap family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:mah]


id: GO:0017038
name: protein import
namespace: biological_process
def:
  "The targeting and directed movement of proteins into a cell or organelle.  Not all import involves an initial targeting event." [GOC:ai]


id: GO:0017039
name: obsolete dipeptidyl-peptidase III activity
namespace: molecular_function
def:
  "OBSOLETE. Catalysis of the release of an N-terminal dipeptide from a peptide comprising four or more residues, with broad specificity; also acts on dipeptidyl 2-naphthylamides." [EC:3.4.14.4]


id: GO:0017041
name: galactosylgalactosylglucosylceramidase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: D-galactosyl-D-galactosyl-D-glucosyl-N-acylsphingosine + H2O = lactosyl-N-acylsphingosine + D-galactose." [EC:3.2.1.47]


id: GO:0017042
name: glycosylceramidase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: glycosyl-N-acylsphingosine + H2O = a sugar + N-acylsphingosine." [EC:3.2.1.62]


id: GO:0017043
name: obsolete adrenocorticotropin
namespace: molecular_function
def:
  "OBSOLETE. A polypeptide hormone which stimulates the adrenal cortex to synthesize and secrete glucocorticoid hormones." [ISBN:0198506732]


id: GO:0017044
name: melanocyte-stimulating hormone activity
namespace: molecular_function
def:
  "The action characteristic of melanocyte-stimulating hormone, any of three peptide hormones that are produced by the intermediate lobe of the pituitary gland and, upon receptor binding, cause dispersal of melanosomes in melanophores of poikilothermic vertebrates." [ISBN:0198506732]


id: GO:0017045
name: corticotropin-releasing hormone activity
namespace: molecular_function
def:
  "The action characteristic of corticotropin-releasing hormone (CRH), any of a number of peptides released by the mammalian hypothalamus into the hypophyseal-portal circulation in response to neural and/or chemical stimuli. Upon receptor binding, CRH increases the rate of corticotropin secretion by the anterior pituitary." [ISBN:0198506732]


id: GO:0017046
name: peptide hormone binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with any peptide with hormonal activity in animals." [GOC:jl, ISBN:0198506732]


id: GO:0017048
name: Rho GTPase binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with Rho protein, any member of the Rho subfamily of the Ras superfamily of monomeric GTPases. Proteins in the Rho subfamily are involved in relaying signals from cell-surface receptors to the actin cytoskeleton." [ISBN:0198547684, PMID:12581856]


id: GO:0017050
name: D-erythro-sphingosine kinase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: sphingosine + ATP = sphingosine 1-phosphate + ADP." [MetaCyc:RXN3DJ-11417]


id: GO:0017051
name: retinol dehydratase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + retinol = adenosine 3',5'-bisphosphate + anhydroretinol." [PMID:9857081]


id: GO:0017054
name: negative cofactor 2 complex
namespace: cellular_component
def:
  "A heterodimeric protein complex that can stably associate with TATA-binding protein on promoters, thereby preventing the assembly of transcription factors TFIIA and TFIIB and leading to repression of RNA polymerase II transcription. The two subunits, NC2alpha (Drap1) and NC2beta (Dr1), dimerize through histone fold domains of the H2A/H2B type present in the amino termini." [PMID:15574413]


id: GO:0017055
name: negative regulation of RNA polymerase II transcriptional preinitiation complex assembly
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of RNA polymerase II transcriptional preinitiation complex assembly." [GOC:go_curators]


id: GO:0017056
name: structural constituent of nuclear pore
namespace: molecular_function
def:
  "The action of a molecule that contributes to the structural integrity of the nuclear pore complex." [GOC:mah]


id: GO:0017057
name: 6-phosphogluconolactonase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 6-O-phosphono-D-glucono-1,5-lactone + H(2)O = 6-phospho-D-gluconate + H(+)." [EC:3.1.1.31, RHEA:12559]


id: GO:0017058
name: FH1 domain binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with a FH1 domain of a protein, a proline-rich domain, usually located in front of a FH2 domain." [GOC:go_curators]


id: GO:0017059
name: serine C-palmitoyltransferase complex
namespace: cellular_component
def:
  "An enzyme complex that catalyzes the transfer of a palmitoyl on to serine, forming 3-dehydro-D-sphinganine." [EC:2.3.1.50]


id: GO:0017060
name: 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: GDP-L-fucose + beta-D-galactosyl-(1,3)-N-acetyl-D-glucosaminyl-R = GDP + beta-D-galactosyl-(1,3)-[alpha-L-fucosyl-(1,4)]-N-acetyl-D-glucosaminyl-R." [EC:2.4.1.65]


id: GO:0017061
name: S-methyl-5-thioadenosine phosphorylase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 5'-methylthioadenosine + phosphate = adenine + 5-methylthio-D-ribose 1-phosphate." [EC:2.4.2.28]


id: GO:0017062
name: respiratory chain complex III assembly
namespace: biological_process
def:
  "The aggregation, arrangement and bonding together of a set of components to form the cytochrome bc(1) complex, a transmembrane lipoprotein complex that it catalyzes the reduction of cytochrome c by accepting reducing equivalents from Coenzyme Q, by the aggregation, arrangement and bonding together of its constituents." [GOC:jl, http://www.brainyencyclopedia.com/]


id: GO:0017063
name: obsolete phosphatidylserine-specific phospholipase A1 activity
namespace: molecular_function
def:
  "OBSOLETE. Catalysis of the reaction: phosphatidylcholine + H2O = 2-acylglycerophosphocholine + a fatty acid anion." [EC:3.1.1.32]


id: GO:0017065
name: single-strand selective uracil DNA N-glycosylase activity
namespace: molecular_function
def:
  "Catalysis of the cleavage of the N-C1' glycosidic bond between the damaged DNA base and the deoxyribose sugar, releasing a free base and leaving an apyrimidinic (AP) site. Enzymes with this activity recognize and remove uracil bases present in single-stranded DNA." [GOC:elh, PMID:9224623]


id: GO:0017067
name: tyrosine-ester sulfotransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 3'-phospho-5'-adenylyl sulfate + L-tyrosine methyl ester = L-tyrosine methyl ester 4-sulfate + adenosine 3',5'-diphosphate + H(+)." [EC:2.8.2.9, RHEA:19980]


id: GO:0017071
name: intracellular cyclic nucleotide activated cation channel complex
namespace: cellular_component
def:
  "A protein complex that forms a transmembrane channel through which cations ions may pass in response to an intracellular cyclic nucleotide binding to the channel complex or one of its constituent parts." [GOC:mah]


id: GO:0017072
name: obsolete tubulin-specific chaperone activity
namespace: molecular_function
def:
  "OBSOLETE. Assists in the correct, non-covalent assembly of tubulin-containing structures in vivo, but is not a component of the assembled structures when performing its normal biological function." [GOC:jl, PMID:11847227]


id: GO:0017074
name: obsolete procollagen N-endopeptidase activity
namespace: molecular_function
def:
  "OBSOLETE. Catalysis of the cleavage of the N-propeptide of collagen chain alpha-1(I) at Pro-Gln and of alpha-1(II) and alpha-2(I) chains at Ala-Gln." [EC:3.4.24.14]


id: GO:0017076
name: purine nucleotide binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with purine nucleotides, any compound consisting of a purine nucleoside esterified with (ortho)phosphate." [GOC:ai]


id: GO:0017077
name: oxidative phosphorylation uncoupler activity
namespace: molecular_function
def:
  "Catalysis of the transfer of protons from mitochondrial intermembrane space into mitochondrial matrix, dissipating the proton gradient across the mitochondrial inner membrane established by the electron transport chain during the oxidative phosphorylation (proton leak). Proton leak uncouples the processes of electron transport/proton generation and ATP synthesis." [PMID:15738989, PMID:16179945]


id: GO:0017078
name: obsolete Hsc70 protein regulator activity
namespace: molecular_function
def:
  "OBSOLETE. Binds to and modulates the activity of the molecular chaperone Hsc70." [GOC:jl, PMID:11121403]


id: GO:0017082
name: mineralocorticoid receptor activity
namespace: molecular_function
def:
  "Combining with a mineralocorticoid and transmitting the signal to the transcriptional machinery by interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription by RNA polymerase II." [GOC:signaling, PMID:20932876]


id: GO:0017083
name: 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: GDP-beta-L-fucose + beta-D-galactosyl-(1,4)-N-acetyl-D-glucosaminyl-R = GDP + 1,4-beta-D-galactosyl-(1,4)-[alpha-L-fucosyl-(1,4)]-N-acetyl-D-glucosaminyl-R." [EC:2.4.1.152]


id: GO:0017084
name: delta1-pyrroline-5-carboxylate synthetase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: L-glutamate + ATP + NADPH = ADP + L-glutamate gamma-semialdehyde + NADP+ + phosphate." [MetaCyc:PROLINE-MULTI]


id: GO:0017085
name: response to insecticide
namespace: biological_process
def:
  "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insecticide stimulus. Insecticides are chemicals used to kill insects." [GOC:curators]


id: GO:0017086
name: 3-methyl-2-oxobutanoate dehydrogenase (lipoamide) complex
namespace: cellular_component
def:
  "A protein complex that catalyzes the reaction 3-methyl-2-oxobutanoate + lipoamide = S-(2-methylpropanoyl)-dihydrolipoamide + carbon dioxide (CO2). This requires thiamine diphosphate; the enzyme also acts on (S)-3-methyl-2-oxopentanoate and 4-methyl-2-oxo-pentanoate." [EC:1.2.4.4]


id: GO:0017087
name: mitochondrial processing peptidase complex
namespace: cellular_component
def:
  "A protein complex that consists of a catalytic alpha subunit (alpha-MPP) and a regulatory beta subunit (beta-MPP), and catalyzes the release of N-terminal targeting peptides from precursor proteins imported into the mitochondrion." [BRENDA:3.4.24.64, EC:3.4.24.64, GOC:mah]


id: GO:0017088
name: obsolete X-Pro dipeptidyl-peptidase activity
namespace: molecular_function
def:
  "OBSOLETE. Catalysis of the hydrolysis of the terminal bond of Xaa-Pro-Xaa motifs to release unblocked, N-terminal dipeptides from substrates including Ala-Pro-para-nitroanilide and (sequentially, at the second, fourth and sixth bonds) of the motif Tyr-Pro-Phe-Pro-Gly-Pro-Ile." [EC:3.4.14.11]


id: GO:0017089
name: glycolipid transporter activity
namespace: molecular_function
def:
  "Enables the directed movement of glycolipids, compounds containing (usually) 1-4 linked monosaccharide residues joined by a glycosyl linkage to a lipid, into, out of or within a cell, or between cells." [GOC:ai]


id: GO:0017090
name: meprin A complex
namespace: cellular_component
def:
  "A protein complex that is located in the cell membrane, and is involved in the metabolism of peptides, including neuropeptides. The complex has metalloendopeptidase activity that catalyzes the hydrolysis of protein and peptide substrates, preferentially on carboxyl side of hydrophobic residues." [EC:3.4.24.18, GOC:mah, MEROPS_fam:M12]


id: GO:0017091
name: AU-rich element binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with a region of RNA containing frequent adenine and uridine bases." [GOC:bf, GOC:mah, PMID:7892223, PMID:8578590]


id: GO:0017092
name: obsolete sterol regulatory element-binding protein site 2 protease activity
namespace: molecular_function
def:
  "OBSOLETE. Catalysis of the cleavage, within the membrane-spanning helix, of the amino-terminal half (the intermediate form) of sterol regulatory element binding protein (SREBP). This activity releases the transcription factor domain of SREBP from the membrane, freeing it to enter the nucleus." [GOC:bf, PMID:12923525]


id: GO:0017093
name: obsolete sterol regulatory element-binding protein protease activity
namespace: molecular_function
def:
  "OBSOLETE. Catalysis of the hydrolysis of peptide bonds within a sterol regulatory element binding protein (SREBP). SREBPs are transcription factors that bind sterol regulatory elements (SREs), DNA motifs found in the promoters of target genes." [GOC:bf, PMID:12923525]


id: GO:0017094
name: obsolete sterol regulatory element-binding protein site 1 protease activity
namespace: molecular_function
def:
  "OBSOLETE. Catalysis of the cleavage of a Leu-Ser bond within the luminal loop of a sterol regulatory element binding protein (SREBP). This activity is the first of two sequential cleavage reactions and cleaves SREBP into two membrane-bound halves." [GOC:bf, PMID:12923525]


id: GO:0017095
name: heparan sulfate 6-O-sulfotransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + heparan sulfate = adenosine 3',5'-bisphosphate + heparan sulfate 6-O-sulfate; results in 6-O-sulfation of glucosamine residues in heparan sulfate." [PMID:8631808]


id: GO:0017096
name: acetylserotonin O-methyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: S-adenosyl-L-methionine + N-acetylserotonin = S-adenosyl-L-homocysteine + melatonin. Melatonin is also known as N-acetyl-5-methoxytryptamine." [EC:2.1.1.4]


id: GO:0017098
name: sulfonylurea receptor binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with the sulfonylurea receptor, a regulatory subunit of the ATP-sensitive potassium ion channel." [GOC:ceb, PMID:11938023]


id: GO:0017099
name: very-long-chain-acyl-CoA dehydrogenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor, where the acyl group is a very long chain fatty acid residue. A very long-chain fatty acid is a fatty acid which has a chain length greater than C22." [CHEBI:27283, GOC:mah]


id: GO:0017101
name: aminoacyl-tRNA synthetase multienzyme complex
namespace: cellular_component
def:
  "A multienzyme complex found in all multicellular eukaryotes composed of eight proteins with aminoacyl-tRNA synthetase activities (abbreviated as: ArgRS, AspRS, GluProRS, GlnRS, IleRS, LeuRS, LysRS, MetRS where RS is the enzyme, preceded by the amino acid it uses as a substrate) as well as three non-synthetase proteins (p43, p38, and p18) with diverse functions. Several of these subunits are known dimers, so the total polypeptide count in the multisynthetase complex is at least fifteen. All of the enzymes in this assembly catalyze the same reaction, the covalent attachment of an amino acid to either the 2'- or 3'-hydroxyl of the 3'-terminal adenosine of tRNA, but using different substrates." [GOC:jl, PMID:16169847]


id: GO:0017102
name: methionyl glutamyl tRNA synthetase complex
namespace: cellular_component
def:
  "A complex consisting of methionyl- and glutamyl-tRNA synthetases. The tRNA synthetases present in the complex bind to their cognate tRNAs more efficiently than they do as monomers." [GOC:mcc, PMID:11069915]


id: GO:0017103
name: UTP:galactose-1-phosphate uridylyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: alpha-D-galactose 1-phosphate + UTP = diphosphate + UDP-D-galactose." [EC:2.7.7.10, RHEA:14212]


id: GO:0017105
name: acyl-CoA delta11-desaturase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: acyl-CoA + reduced acceptor + O2 = delta11-acyl-CoA + acceptor + 2 H2O." [EC:1.14.19.5]


id: GO:0017106
name: obsolete activin inhibitor activity
namespace: molecular_function
def:
  "OBSOLETE. Acts to negatively regulate the activity of activin, a nonsteroidal regulator synthesized in the pituitary gland and gonads that stimulates the secretion of follicle-stimulating hormone." [ISBN:0198506732, ISBN:0721662544]


id: GO:0017107
name: anion exchanger adaptor activity
namespace: molecular_function
def:
  "The binding activity of a molecule that brings together an anion exchanger and one or more other molecules, permitting them to function in a coordinated way." [GOC:mtg_MIT_16mar07]


id: GO:0017108
name: 5'-flap endonuclease activity
namespace: molecular_function
def:
  "Catalysis of the cleavage of a 5' flap structure in DNA, but not other DNA structures; processes the 5' ends of Okazaki fragments in lagging strand DNA synthesis." [PMID:9778254]


id: GO:0017109
name: glutamate-cysteine ligase complex
namespace: cellular_component
def:
  "An enzyme complex that catalyzes the ligation of glutamate to cysteine, forming glutamylcysteine." [EC:6.3.2.2]


id: GO:0017110
name: nucleoside-diphosphatase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: a nucleoside diphosphate + H2O = a nucleotide + phosphate." [EC:3.6.1.6]


id: GO:0017111
name: nucleoside-triphosphatase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15]


id: GO:0017112
name: Rab guanyl-nucleotide exchange factor activity
namespace: molecular_function
def:
  "Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rab family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:mah]


id: GO:0017114
name: obsolete wide-spectrum protease inhibitor activity
namespace: molecular_function
def:
  "OBSOLETE. Stops, prevents or reduces the activity of a protease by a wide-spectrum protease inhibitor. A wide-spectrum protease inhibitor is a protein having a peptide stretch which contains specific cleavage sites for different proteinases enabling inhibition of all four classes of proteinases by formation of a covalent bond between the inhibitor and the protease." [GOC:dph, GOC:tb]


id: GO:0017116
name: single-stranded DNA-dependent ATP-dependent DNA helicase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: ATP + H2O = ADP + phosphate, in the presence of single-stranded DNA; drives the unwinding of a DNA helix." [EC:3.6.1.3, GOC:jl]


id: GO:0017118
name: lipoyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the transfer of the lipoyl group from lipoyl-AMP to the lysine residue of lipoate-dependent enzyme." [PMID:10103005]


id: GO:0017119
name: Golgi transport complex
namespace: cellular_component
def:
  "A complex of proteins that, in vitro, stimulates intra-Golgi transport; a 13S complex, about 800 kDa in size and consists of at least five polypeptides. In yeast, this complex is called the Sec34/35 complex and is composed of eight subunits (Sec34p, Sec35p, Dor1p, Cod1p, Cod2p, Cod3p, Cod4p, and Cod5p)." [GOC:krc, PMID:9792665]


id: GO:0017120
name: obsolete polyphosphatidylinositol phosphatase activity
namespace: molecular_function
def:
  "OBSOLETE. Catalysis of the conversion of phosphatidylinositol-3-phosphate, phosphatidylinositol-4-phosphate, and phosphatidylinositol-3,5-bisphosphate, but not PI-4,5-bisphosphate, to phosphatidylinositol; PPIPase activity is a key regulator of membrane trafficking and actin cytoskeleton organization." [PMID:10224048]


id: GO:0017121
name: phospholipid scrambling
namespace: biological_process
def:
  "The movement of a population of phospholipid molecules from one leaflet of the plasma membrane bilayer to the opposite leaflet, resulting in loss of lipid asymmetry and surface exposure of phosphatidylserine (PS) and phosphatidylethanolamine (PE)." [GOC:cjm, PMID:20043909, PMID:20302864]


id: GO:0017122
name: protein N-acetylglucosaminyltransferase complex
namespace: cellular_component
def:
  "Heterotrimeric enzyme complex, which in humans is composed of two large subunits of the same size, and one smaller subunit. Functions in the addition of nucleotide-activated sugars onto the polypeptide." [PMID:15247246]


id: GO:0017124
name: SH3 domain binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with a SH3 domain (Src homology 3) of a protein, small protein modules containing approximately 50 amino acid residues found in a great variety of intracellular or membrane-associated proteins." [GOC:go_curators, Pfam:PF00018]


id: GO:0017125
name: deoxycytidyl transferase activity
namespace: molecular_function
def:
  "Catalysis of the insertion of a dCMP residue opposite a template abasic site in DNA." [PMID:10535901]


id: GO:0017126
name: nucleologenesis
namespace: biological_process
def:
  "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a nucleolus, a small, dense body one or more of which are present in the nucleus of eukaryotic cells." [GOC:jl, ISBN:0198506732]


id: GO:0017127
name: cholesterol transporter activity
namespace: molecular_function
def:
  "Enables the directed movement of cholesterol into, out of or within a cell, or between cells. Cholesterol is the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones." [GOC:ai]


id: GO:0017128
name: phospholipid scramblase activity
namespace: molecular_function
def:
  "Catalysis of the movement of phospholipids from one membrane bilayer leaflet to the other, by an ATP-independent mechanism." [GOC:cjm, PMID:20043909, PMID:20302864]


id: GO:0017129
name: triglyceride binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with any triester of glycerol." [GOC:jl, ISBN:0198506732]


id: GO:0017130
name: poly(C) RNA binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with a sequence of cytosine residues in an RNA molecule." [GOC:mah]


id: GO:0017131
name: uridine-rich cytoplasmic polyadenylylation element binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with U-rich sequence in the 3'-end of nuclear-transcribed mRNAs; required for cytoplasmic polyadenylylation." [GOC:krc, PMID:7954828]


id: GO:0017132
name: cyclic nucleotide-dependent guanyl-nucleotide exchange factor activity
namespace: molecular_function
def:
  "Stimulates the exchange of guanyl nucleotides associated with a GTPase; dependent on the presence of a cyclic nucleotide." [GOC:mah, PMID:9856955]


id: GO:0017133
name: mitochondrial electron transfer flavoprotein complex
namespace: cellular_component
def:
  "A protein complex located in the mitochondrion. It contains flavin adenine dinucleotide (FAD) that, together with an acyl-CoA dehydrogenase, forms a system that oxidizes an acyl-CoA molecule and reduces ubiquinone and other acceptors in the mitochondrial electron transport system." [GOC:mtg_sensu, ISBN:0198506732]


id: GO:0017135
name: obsolete membrane-associated protein with guanylate kinase activity interacting
namespace: molecular_function
def:
  "OBSOLETE. The interaction with synapse-associated membrane-associated protein with guanylate kinase activity." [PMID:10207005]


id: GO:0017136
name: NAD-dependent histone deacetylase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: histone N6-acetyl-L-lysine + H2O = histone L-lysine + acetate. This reaction requires the presence of NAD, and represents the removal of an acetyl group from a histone." [EC:3.5.1.17, RHEA:24551]


id: GO:0017137
name: Rab GTPase binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with Rab protein, any member of the Rab subfamily of the Ras superfamily of monomeric GTPases." [GOC:mah]


id: GO:0017143
name: insecticide metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving insecticides, chemicals used to kill insects." [GOC:ai]


id: GO:0017144
name: drug metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving a drug, a substance used in the diagnosis, treatment or prevention of a disease; as used here antibiotic substances (see antibiotic metabolism) are considered to be drugs, even if not used in medical or veterinary practice." [GOC:cab2]


id: GO:0017145
name: stem cell division
namespace: biological_process
def:
  "The self-renewing division of a stem cell. A stem cell is an undifferentiated cell, in the embryo or adult, that can undergo unlimited division and give rise to one or several different cell types." [GOC:jid, ISBN:0582227089]


id: GO:0017146
name: NMDA selective glutamate receptor complex
namespace: cellular_component
def:
  "An assembly of four or five subunits which form a structure with an extracellular N-terminus and a large loop that together form the ligand binding domain. The C-terminus is intracellular. The ionotropic glutamate receptor complex itself acts as a ligand gated ion channel; on binding glutamate, charged ions pass through a channel in the center of the receptor complex. NMDA receptors are composed of assemblies of NR1 subunits (Figure 3) and NR2 subunits, which can be one of four separate gene products (NR2A-D). Expression of both subunits are required to form functional channels. The glutamate binding domain is formed at the junction of NR1 and NR2 subunits. NMDA receptors are permeable to calcium ions as well as being permeable to other ions. Thus NMDA receptor activation leads to a calcium influx into the post-synaptic cells, a signal thought to be crucial for the induction of NMDA-receptor dependent LTP and LTD." [http://www.bris.ac.uk/Depts/Synaptic/info/glutamate.html]


id: GO:0017147
name: Wnt-protein binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with Wnt-protein, a secreted growth factor involved in signaling." [GOC:jl]


id: GO:0017148
name: negative regulation of translation
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA." [GOC:isa_complete]


id: GO:0017150
name: tRNA dihydrouridine synthase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: tRNA-uracil + acceptor = tRNA-dihydrouridine + reduced acceptor." [PMID:11983710]


id: GO:0017153
name: sodium:dicarboxylate symporter activity
namespace: molecular_function
def:
  "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in)." [GOC:ai]


id: GO:0017154
name: semaphorin receptor activity
namespace: molecular_function
def:
  "Combining with a semaphorin, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:mah, GOC:signaling, PMID:15239958]


id: GO:0017156
name: calcium ion regulated exocytosis
namespace: biological_process
def:
  "The release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle by fusion of the vesicle with the plasma membrane of a cell, induced by a rise in cytosolic calcium-ion levels." [GOC:go_curators]


id: GO:0017158
name: regulation of calcium ion-dependent exocytosis
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of calcium ion-dependent exocytosis." [GOC:go_curators]


id: GO:0017159
name: pantetheine hydrolase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: (R)-pantetheine + H(2)O = (R)-pantothenate + cysteamine." [EC:3.5.1.92, RHEA:13448]


id: GO:0017160
name: Ral GTPase binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with Ral protein, any member of the Ral subfamily of the Ras superfamily of monomeric GTPases." [GOC:mah]


id: GO:0017161
name: inositol-1,3,4-trisphosphate 4-phosphatase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: D-myo-inositol 1,3,4-trisphosphate + H2O = myo-inositol 1,3-bisphosphate + phosphate." [GOC:ai]


id: GO:0017163
name: obsolete basal transcription repressor activity
namespace: molecular_function
def:
  "OBSOLETE. Any transcription regulator activity that prevents or downregulates basal transcription. Basal transcription results from transcription that is controlled by the minimal complement of proteins necessary to reconstitute transcription from a minimal promoter." [GOC:dph, GOC:tb, http://tfib.med.harvard.edu/transcription/basaltx.html]


id: GO:0017165
name: obsolete dipeptidase E activity
namespace: molecular_function
def:
  "OBSOLETE. Catalysis of the hydrolysis of dipeptides Asp-Xaa; does not act on peptides with N-terminal Glu, Asn or Gln, nor does it cleave isoaspartyl peptides." [EC:3.4.13.21]


id: GO:0017166
name: vinculin binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with vinculin, a protein found in muscle, fibroblasts, and epithelial cells that binds actin and appears to mediate attachment of actin filaments to integral proteins of the plasma membrane." [ISBN:0721662544]


id: GO:0017168
name: 5-oxoprolinase (ATP-hydrolyzing) activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 5-oxo-L-proline + ATP + 2 H(2)O = L-glutamate + ADP + 2 H(+) + phosphate." [EC:3.5.2.9, RHEA:10351]


id: GO:0017170
name: obsolete KU70 binding
namespace: molecular_function
def:
  "OBSOLETE. Interacting selectively and non-covalently with Ku70, a protein involved in non-homologous DNA end joining." [GOC:mah, PMID:14739985]


id: GO:0017171
name: serine hydrolase activity
namespace: molecular_function
def:
  "Catalysis of the hydrolysis of a substrate by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [Wikipedia:Serine_hydrolase]


id: GO:0017172
name: cysteine dioxygenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: L-cysteine + O(2) = 3-sulfino-L-alanine + H(+)." [EC:1.13.11.20, RHEA:20444]


id: GO:0017174
name: glycine N-methyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: S-adenosyl-L-methionine + glycine = S-adenosyl-L-homocysteine + sarcosine." [EC:2.1.1.20]


id: GO:0017175
name: obsolete IMP-GMP specific 5'-nucleotidase activity
namespace: molecular_function
def:
  "OBSOLETE. Catalysis of the conversion of 5'-ribonucleotides to ribonucleosides and phosphate, with specificity for IMP or GMP 5'-ribonucleotides and H2O as a nucleophile." [EC:3.1.3.5, GOC:krc]


id: GO:0017176
name: phosphatidylinositol N-acetylglucosaminyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + phosphatidylinositol = UDP + N-acetyl-D-glucosaminylphosphatidylinositol." [EC:2.4.1.198]


id: GO:0017177
name: glucosidase II complex
namespace: cellular_component
def:
  "A heterodimeric complex that catalyzes the trimming of glucose residues from N-linked core glycans on newly synthesized glycoproteins." [PMID:10464333, PMID:8910335]


id: GO:0017178
name: diphthine-ammonia ligase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: ATP + diphthine + NH(4)(+) = ADP + diphthamide + H(+) + phosphate." [EC:6.3.1.14, RHEA:19756]


id: GO:0017179
name: peptidyl-diphthine metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving peptidyl-diphthine, a modified histidine residue." [GOC:go_curators]


id: GO:0017180
name: peptidyl-diphthine biosynthetic process from peptidyl-histidine
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of peptidyl-diphthine from other compounds, including peptidyl-histidine." [GOC:go_curators]


id: GO:0017181
name: peptidyl-diphthine catabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the breakdown of peptidyl-diphthine, a modified histidine residue." [GOC:go_curators]


id: GO:0017182
name: peptidyl-diphthamide metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving peptidyl-diphthamide, a modified histidine residue." [GOC:go_curators]


id: GO:0017183
name: peptidyl-diphthamide biosynthetic process from peptidyl-histidine
namespace: biological_process
def:
  "The modification of peptidyl-histidine to 2'-(3-carboxamido-3-(trimethylammonio)propyl)-L-histidine, known as diphthamide, found in translation elongation factor EF-2. The process occurs in eukaryotes and archaea but not eubacteria." [GOC:pde, PMID:20559380, RESID:AA0040]


id: GO:0017184
name: peptidyl-diphthamide catabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the breakdown of peptidyl-diphthamide, a modified histidine residue." [GOC:go_curators]


id: GO:0017186
name: peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of peptidyl-pyroglutamic acid, catalyzed by glutaminyl-peptide cyclotransferase." [RESID:AA0031]


id: GO:0017187
name: peptidyl-glutamic acid carboxylation
namespace: biological_process
def:
  "The gamma-carboxylation of peptidyl-glutamic acid; catalyzed by the vitamin K dependent gamma-glutamyl carboxylase." [RESID:AA0032]


id: GO:0017188
name: aspartate N-acetyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: L-aspartate + acetyl-CoA = N-acetyl-L-aspartate + CoA + H(+)." [EC:2.3.1.17, RHEA:14168]


id: GO:0017189
name: N-terminal peptidyl-alanine acetylation
namespace: biological_process
def:
  "The acetylation of the N-terminal alanine of proteins; catalyzed by peptide alpha-N-acetyltransferase or other enzymes of this class, such as ribosomal-protein-alanine N-acetyltransferase." [RESID:AA0041]


id: GO:0017190
name: N-terminal peptidyl-aspartic acid acetylation
namespace: biological_process
def:
  "The acetylation of the N-terminal aspartic acid of proteins; catalyzed by aspartate N-acetyltransferase." [RESID:AA0042]


id: GO:0017192
name: N-terminal peptidyl-glutamine acetylation
namespace: biological_process
def:
  "The acetylation of a glutamine residue in protein to form the N5-methyl-L-glutamine derivative. The occurrence of this modification has not been confirmed. Its annotation in sequence databases is either due to the misidentification of 2-pyrrolidone-5-carboxylic acid, or to inappropriate homolog comparisons when proteolytic modification is more probable." [RESID:AA0045]


id: GO:0017193
name: N-terminal peptidyl-glycine acetylation
namespace: biological_process
def:
  "The acetylation of the N-terminal glycine of proteins to form the derivative N-acetylglycine." [RESID:AA0046]


id: GO:0017194
name: N-terminal peptidyl-isoleucine acetylation
namespace: biological_process
def:
  "The acetylation of the N-terminal isoleucine of proteins to form the derivative N-acetyl-L-isoleucine. The occurrence of this modification has not been confirmed." [RESID:AA0047]


id: GO:0017195
name: N-terminal peptidyl-lysine N2-acetylation
namespace: biological_process
def:
  "The acetylation of the N-terminal lysine of proteins to form the derivative N2-acetyl-L-lysine. The occurrence of this modification has not been confirmed." [RESID:AA0048]


id: GO:0017196
name: N-terminal peptidyl-methionine acetylation
namespace: biological_process
def:
  "The acetylation of the N-terminal methionine of proteins to form the derivative N-acetyl-L-methionine." [RESID:AA0049]


id: GO:0017197
name: N-terminal peptidyl-proline acetylation
namespace: biological_process
def:
  "The acetylation of the N-terminal proline of proteins to form the derivative N-acetyl-L-proline." [RESID:AA0050]


id: GO:0017198
name: N-terminal peptidyl-serine acetylation
namespace: biological_process
def:
  "The acetylation of the N-terminal serine of proteins to form the derivative N-acetyl-L-serine." [RESID:AA0051]


id: GO:0017199
name: N-terminal peptidyl-threonine acetylation
namespace: biological_process
def:
  "The acetylation of the N-terminal threonine of proteins to form the derivative N-acetyl-L-threonine; catalyzed by peptide alpha-N-acetyltransferase." [RESID:AA0052]


id: GO:0018000
name: N-terminal peptidyl-tyrosine acetylation
namespace: biological_process
def:
  "The acetylation of the N-terminal tyrosine of proteins to form the derivative N-acetyl-L-tyrosine." [RESID:AA0053]


id: GO:0018001
name: N-terminal peptidyl-valine acetylation
namespace: biological_process
def:
  "The acetylation of the N-terminal tyrosine of proteins to form the derivative N-acetyl-L-valine." [RESID:AA0054]


id: GO:0018002
name: N-terminal peptidyl-glutamic acid acetylation
namespace: biological_process
def:
  "The acetylation of the N-terminal glutamic acid of proteins to form the derivate acetyl-glutamic acid." [RESID:AA0044]


id: GO:0018003
name: peptidyl-lysine N6-acetylation
namespace: biological_process
def:
  "The acetylation of the peptidyl-lysine of proteins to form the derivative peptidyl-N6-acetyl-L-lysine." [RESID:AA0055]


id: GO:0018005
name: N-terminal peptidyl-glycine N-formylation
namespace: biological_process
def:
  "The formylation of the N-terminal glycine of proteins to form the derivative N-formylglycine." [RESID:AA0057]


id: GO:0018007
name: N-terminal peptidyl-glycine N-glucuronylation
namespace: biological_process
def:
  "The glucuronylation of the N-terminal glycine of proteins to form the derivative D-glucuronyl-N-glycine." [RESID:AA0058]


id: GO:0018008
name: N-terminal peptidyl-glycine N-myristoylation
namespace: biological_process
def:
  "The myristoylation of the N-terminal glycine of proteins to form the derivative N-myristoyl-glycine." [RESID:AA0059]


id: GO:0018009
name: N-terminal peptidyl-L-cysteine N-palmitoylation
namespace: biological_process
def:
  "The covalent attachment of a palmitoyl group to a nitrogen (N) atom in an N-terminal cysteine residue to form N-palmitoyl-L-cysteine." [RESID:AA0060]


id: GO:0018010
name: glycoprotein N-palmitoyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: palmitoyl-CoA + glycoprotein = CoA + N-palmitoylglycoprotein." [EC:2.3.1.96]


id: GO:0018012
name: N-terminal peptidyl-alanine trimethylation
namespace: biological_process
def:
  "The trimethylation of the N-terminal alanine of proteins to form the derivative peptidyl-N,N,N-trimethyl-L-alanine." [RESID:AA0062]


id: GO:0018013
name: N-terminal peptidyl-glycine methylation
namespace: biological_process
def:
  "The methylation of the N-terminal glycine of proteins to form the derivative N-methylglycine." [RESID:AA0063]


id: GO:0018014
name: N-terminal peptidyl-methionine methylation
namespace: biological_process
def:
  "The methylation of the N-terminal methionine of proteins to form the derivative N-methyl-L-methionine." [RESID:AA0064]


id: GO:0018015
name: N-terminal peptidyl-phenylalanine methylation
namespace: biological_process
def:
  "The methylation of the N-terminal phenylalanine of proteins to form the derivative N-methyl-L-phenylalanine." [RESID:AA0065]


id: GO:0018016
name: N-terminal peptidyl-proline dimethylation
namespace: biological_process
def:
  "The methylation of the N-terminal proline of proteins to form the derivative N,N-dimethyl-L-proline." [RESID:AA0066]


id: GO:0018019
name: N-terminal peptidyl-glutamine methylation
namespace: biological_process
def:
  "The methylation of a glutamine residue in proteins to form the peptidyl-N5-methyl-L-glutamine derivative." [RESID:AA0071]


id: GO:0018021
name: peptidyl-histidine methylation
namespace: biological_process
def:
  "The methylation of peptidyl-L-histidine to form peptidyl-L-1'-methyl-L-histidine (otherwise known as tau-methylhistidine, tele-methylhistidine) or peptidyl-L-3'-methyl-L-histidine (otherwise known as pi-methylhistidine, pros-methylhistidine)." [RESID:AA0073, RESID:AA0317]


id: GO:0018022
name: peptidyl-lysine methylation
namespace: biological_process
def:
  "The methylation of peptidyl-lysine to form either the mono-, di- or trimethylated derivative." [GOC:ai]


id: GO:0018024
name: histone-lysine N-methyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: S-adenosyl-L-methionine + histone L-lysine = S-adenosyl-L-homocysteine + histone N6-methyl-L-lysine. The methylation of peptidyl-lysine in histones forms N6-methyl-L-lysine, N6,N6-dimethyl-L-lysine and N6,N6,N6-trimethyl-L-lysine derivatives." [EC:2.1.1.43, RESID:AA0074, RESID:AA0075, RESID:AA0076]


id: GO:0018025
name: calmodulin-lysine N-methyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: S-adenosyl-L-methionine + calmodulin L-lysine = S-adenosyl-L-homocysteine + calmodulin N6-methyl-L-lysine." [EC:2.1.1.60]


id: GO:0018030
name: peptidyl-lysine N6-myristoyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the transfer of a myristoyl group to the N6 nitrogen atom on a lysine residue of a peptide or protein molecule." [GOC:mah]


id: GO:0018031
name: peptidyl-lysine N6-palmitoyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the transfer of a palmitoyl group to the N6 nitrogen atom on a lysine residue of a peptide or protein molecule." [GOC:mah]


id: GO:0018033
name: protein C-terminal amidation
namespace: biological_process
def:
  "The formation of a C-terminal amide by hydrolysis and oxidation of an interior peptide in a secreted protein." [GOC:ai]


id: GO:0018034
name: C-terminal peptidyl-alanine amidation
namespace: biological_process
def:
  "The formation of a C-terminal peptidyl-alanine amide by hydrolysis and oxidation of an interior Ala-Gly peptide in a secreted protein." [RESID:AA0081]


id: GO:0018035
name: C-terminal peptidyl-arginine amidation
namespace: biological_process
def:
  "The formation of a C-terminal peptidyl-arginine amide by hydrolysis and oxidation of an interior Arg-Gly peptide in a secreted protein." [RESID:AA0082]


id: GO:0018036
name: C-terminal peptidyl-asparagine amidation
namespace: biological_process
def:
  "The formation of a C-terminal peptidyl-asparagine amide by hydrolysis and oxidation of an interior Asn-Gly peptide in a secreted protein." [RESID:AA0083]


id: GO:0018037
name: C-terminal peptidyl-aspartic acid amidation
namespace: biological_process
def:
  "The formation of a C-terminal peptidyl-aspartic acid 1-amide by hydrolysis and oxidation of an interior Asp-Gly peptide in a secreted protein." [RESID:AA0084]


id: GO:0018038
name: C-terminal peptidyl-cysteine amidation
namespace: biological_process
def:
  "The formation of a C-terminal peptidyl-cysteine amide by hydrolysis and oxidation of an interior Cys-Gly peptide in a secreted protein." [RESID:AA0085]


id: GO:0018039
name: C-terminal peptidyl-glutamine amidation
namespace: biological_process
def:
  "The formation of a C-terminal peptidyl-glutamine amide by hydrolysis and oxidation of an interior Gln-Gly peptide in a secreted protein." [RESID:AA0086]


id: GO:0018040
name: C-terminal peptidyl-glutamic acid amidation
namespace: biological_process
def:
  "The formation of a C-terminal peptidyl-glutamic acid amide by hydrolysis and oxidation of an interior Glu-Gly peptide in a secreted protein." [RESID:AA0087]


id: GO:0018041
name: C-terminal peptidyl-glycine amidation
namespace: biological_process
def:
  "The formation of a C-terminal peptidyl-glycine acid amide by hydrolysis and oxidation of an interior Gly-Gly peptide in a secreted protein." [RESID:AA0088]


id: GO:0018042
name: C-terminal peptidyl-histidine amidation
namespace: biological_process
def:
  "The formation of a C-terminal peptidyl-histidine amide by hydrolysis and oxidation of an interior His-Gly peptide in a secreted protein." [RESID:AA0089]


id: GO:0018043
name: C-terminal peptidyl-isoleucine amidation
namespace: biological_process
def:
  "The formation of a C-terminal peptidyl-isoleucine amide by hydrolysis and oxidation of an interior Ile-Gly peptide in a secreted protein." [RESID:AA0090]


id: GO:0018044
name: C-terminal peptidyl-leucine amidation
namespace: biological_process
def:
  "The formation of a C-terminal peptidyl-leucine amide by hydrolysis and oxidation of an interior Leu-Gly peptide in a secreted protein." [RESID:AA0091]


id: GO:0018045
name: C-terminal peptidyl-lysine amidation
namespace: biological_process
def:
  "The formation of a C-terminal peptidyl-lysine amide by hydrolysis and oxidation of an interior Lys-Gly peptide in a secreted protein." [RESID:AA0092]


id: GO:0018046
name: C-terminal peptidyl-methionine amidation
namespace: biological_process
def:
  "The formation of a C-terminal peptidyl-methionine amide by hydrolysis and oxidation of an interior Met-Gly peptide in a secreted protein." [RESID:AA0093]


id: GO:0018047
name: C-terminal peptidyl-phenylalanine amidation
namespace: biological_process
def:
  "The formation of a C-terminal peptidyl-phenylalanine amide by hydrolysis and oxidation of an interior Phe-Gly peptide in a secreted protein." [RESID:AA0094]


id: GO:0018048
name: C-terminal peptidyl-proline amidation
namespace: biological_process
def:
  "The formation of a C-terminal peptidyl-proline amide by hydrolysis and oxidation of an interior Pro-Gly peptide in a secreted protein." [RESID:AA0095]


id: GO:0018049
name: C-terminal peptidyl-serine amidation
namespace: biological_process
def:
  "The formation of a C-terminal peptidyl-serine amide by hydrolysis and oxidation of an interior Ser-Gly peptide in a secreted protein." [RESID:AA0096]


id: GO:0018050
name: C-terminal peptidyl-threonine amidation
namespace: biological_process
def:
  "The formation of a C-terminal peptidyl-threonine amide by hydrolysis and oxidation of an interior Thr-Gly peptide in a secreted protein." [RESID:AA0097]


id: GO:0018051
name: C-terminal peptidyl-tryptophan amidation
namespace: biological_process
def:
  "The formation of a C-terminal peptidyl-tryptophan amide by hydrolysis and oxidation of an interior Trp-Gly peptide in a secreted protein." [RESID:AA0098]


id: GO:0018052
name: C-terminal peptidyl-tyrosine amidation
namespace: biological_process
def:
  "The formation of a C-terminal peptidyl-tyrosine amide by hydrolysis and oxidation of an interior Tyr-Gly peptide in a secreted protein." [RESID:AA0099]


id: GO:0018053
name: C-terminal peptidyl-valine amidation
namespace: biological_process
def:
  "The formation of a C-terminal peptidyl-valine amide by hydrolysis and oxidation of an interior Val-Gly peptide in a secreted protein." [RESID:AA0100]


id: GO:0018054
name: peptidyl-lysine biotinylation
namespace: biological_process
def:
  "The covalent modification of peptidyl-lysine by biotin to form peptidyl-N6-biotinyl-L-lysine." [RESID:AA0117]


id: GO:0018057
name: peptidyl-lysine oxidation
namespace: biological_process
def:
  "The oxidation of the terminal amino-methylene groups of peptidyl-L-lysine or peptidyl-5-hydroxy-L-lysine to aldehyde groups to form allysine or hydroxyallysine residues, respectively; these are intermediates in the formation of covalent cross-links between adjacent polypeptide chains in proteins such as collagens." [ISBN:0198547684, RESID:AA0121]


id: GO:0018058
name: N-terminal protein amino acid deamination, from amino carbon
namespace: biological_process
def:
  "The oxidative deamination of the alpha carbon of an encoded N-terminal amino acid, to form pyruvic acid retaining an amide bond between its 1-carboxyl group and the adjacent residue. The pyruvate 2-oxo group may become an enzyme active site, or it may be reduced to an alcohol." [RESID:AA0127, RESID:AA0128, RESID:AA0129]


id: GO:0018059
name: N-terminal peptidyl-serine deamination
namespace: biological_process
def:
  "The oxidative deamination of N-terminal peptidyl-serine to form pyruvic acid with an amide bond between its 1-carboxyl group and the N-terminal residue." [RESID:AA0127]


id: GO:0018060
name: N-terminal peptidyl-cysteine deamination
namespace: biological_process
def:
  "The oxidative deamination of N-terminal peptidyl-cysteine to form pyruvic acid with an amide bond between its 1-carboxyl group and the N-terminal residue." [RESID:AA0127]


id: GO:0018061
name: peptidyl-L-3-phenyllactic acid biosynthetic process from peptidyl-phenylalanine
namespace: biological_process
def:
  "The modification of a N-terminal peptidyl-phenylalanine residue by either oxidative deamination or by transamination and subsequent reduction to form peptidyl-L-3-phenyllactic acid." [RESID:AA0128]


id: GO:0018062
name: peptidyl-tryptophan succinylation
namespace: biological_process
def:
  "The modification of an N-terminal peptidyl-tryptophan residue to form peptidyl-N2-succinyl-L-tryptophan." [RESID:AA0130]


id: GO:0018064
name: protein-histidine N-methyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: S-adenosyl-L-methionine + protein L-histidine = S-adenosyl-L-homocysteine + protein N-methyl-L-histidine." [EC:2.1.1.85]


id: GO:0018067
name: peptidyl-L-3',4'-dihydroxyphenylalanine biosynthetic process from peptidyl-tyrosine
namespace: biological_process
def:
  "The modification of protein tyrosine to peptidyl-L-3',4'-dihydroxyphenylalanine (DOPA)." [RESID:AA0146]


id: GO:0018068
name: peptidyl-L-2',4',5'-topaquinone biosynthetic process from peptidyl-tyrosine
namespace: biological_process
def:
  "The modification of protein tyrosine to L-2',4',5'-topaquinone, characteristic of the active site of copper amine oxidases." [RESID:AA0147]


id: GO:0018069
name: peptide cross-linking via 4'-(L-tryptophan)-L-tryptophyl quinone
namespace: biological_process
def:
  "The cross-linking of a tryptophan residue to tryptophyl quinone to form 4'-(L-tryptophan)-L-tryptophyl quinone, a cofactor found at the active site of methylamine dehydrogenase." [RESID:AA0149]


id: GO:0018070
name: peptidyl-serine phosphopantetheinylation
namespace: biological_process
def:
  "The phosphopantetheinylation of peptidyl-serine to form peptidyl-O-phosphopantetheine-L-serine." [RESID:AA0150]


id: GO:0018071
name: NAD(P)-cysteine ADP-ribosyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: NAD(P)+ + L-cysteine = nicotinamide + N2-(ADP-D-ribosyl)-L-cysteine." [EC:2.4.2.-]


id: GO:0018072
namespace: biological_process
name:
  peptidyl-L-glutamyl 5-glycerylphosphorylethanolamine biosynthetic process from peptidyl-glutamic acid

def:
  "The modification of peptidyl-glutamic acid residues by the covalent attachment of ethanolamine, itself further modified by the addition of a phosphoglycerol unit." [PMID:2569467, RESID:AA0170]


id: GO:0018074
name: peptidyl-histidine bromination
namespace: biological_process
def:
  "The bromination of peptidyl-histidine to form peptidyl-L-bromohistidine; the position of the bromine substitution is unknown." [RESID:AA0173]


id: GO:0018081
name: peptide cross-linking via lanthionine or 3-methyl-lanthionine
namespace: biological_process
def:
  "The synthesis of (2R,6R)-lanthionine, sn-(2S,6R)-lanthionine or (2S,3S,6R)-3-methyl-lanthionine, forming an intra-polypeptide cross-link between peptidyl-cysteine, and peptidyl-serine or peptidyl-threonine; dehydration of the serine or threonine residue to the alpha,beta-unsaturated amino acid is the first step; a bond then forms between the ethylene (ethene) group thus formed and the sulfur atom of a cysteine, with the inversion of the configuration of the alpha carbon of the serine or threonine occurring during the process." [ISBN:0198547684, RESID:AA0110, RESID:AA0111, RESID:AA0112]


id: GO:0018083
name: peptidyl-L-3-oxoalanine biosynthetic process from peptidyl-cysteine or peptidyl-serine
namespace: biological_process
def:
  "The modification of peptidyl-cysteine or peptidyl-serine to peptidyl-L-3-oxoalanine; characteristic of the active sites of arylsulfatases." [RESID:AA0185]


id: GO:0018085
name: peptidyl-L-amino acid racemization
namespace: biological_process
def:
  "The process of conversion of a L-amino acid into its enantiomer, the corresponding D-amino acid." [GOC:ma]


id: GO:0018094
name: protein polyglycylation
namespace: biological_process
def:
  "The addition of glycyl units covalently bound to the gamma carboxyl group peptidyl-glutamic acid." [RESID:AA0201]


id: GO:0018095
name: protein polyglutamylation
namespace: biological_process
def:
  "The addition of one or more alpha-linked glutamyl units to the gamma carboxyl group of peptidyl-glutamic acid." [RESID:AA0202]


id: GO:0018096
name: peptide cross-linking via S-(2-aminovinyl)-D-cysteine
namespace: biological_process
def:
  "The synthesis of (S,Z)-S-(2-aminovinyl)cysteine forming an intra-polypeptide cross-link between serine and cysteine." [RESID:AA0204]


id: GO:0018103
name: protein C-linked glycosylation
namespace: biological_process
def:
  "A protein glycosylation process in which a carbohydrate or carbohydrate derivative unit is added to a protein via a C atom." [GOC:pr, PMID:7947762, RESID:AA0217]


id: GO:0018106
name: peptidyl-histidine phosphorylation
namespace: biological_process
def:
  "The phosphorylation of peptidyl-histidine to form peptidyl-1'-phospho-L-histidine (otherwise known as tau-phosphohistidine, tele-phosphohistidine) or peptidyl-3'-phospho-L-histidine (otherwise known as pi-phosphohistidine, pros-phosphohistidine)." [RESID:AA0035, RESID:AA0036]


id: GO:0018110
name: histone arginine kinase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: histone L-arginine + ATP = histone N(omega)-phospho-L-arginine + ADP + 2 H(+)." [GOC:mah]


id: GO:0018115
name: peptidyl-S-diphytanylglycerol diether-L-cysteine biosynthetic process from peptidyl-cysteine
namespace: biological_process
def:
  "The modification of cysteine to form peptidyl-S-diphytanylglycerol diether-L-cysteine." [PMID:7797461, RESID:AA0223]


id: GO:0018116
name: peptidyl-lysine adenylylation
namespace: biological_process
def:
  "The adenylylation of peptidyl-lysine to form peptidyl-N6-(phospho-5'-adenosine)-L-lysine." [RESID:AA0227]


id: GO:0018117
name: protein adenylylation
namespace: biological_process
def:
  "The addition of an adenylyl group (adenosine 5'-monophosphate; AMP) to a protein amino acid." [GOC:ai, GOC:jsg, GOC:sart, PMID:21607083]


id: GO:0018118
name: peptidyl-L-cysteine glutathione disulfide biosynthetic process from peptidyl-cysteine
namespace: biological_process
def:
  "The modification of peptidyl-cysteine by covalent addition of glutathione to form peptidyl-L-cysteine glutathione disulfide." [RESID:AA0229]


id: GO:0018119
name: peptidyl-cysteine S-nitrosylation
namespace: biological_process
def:
  "The covalent addition of a nitric oxide (NO) group to the sulphur (S) atom of a cysteine residue in a protein, to form peptidyl-S-nitrosyl-L-cysteine." [RESID:AA0230]


id: GO:0018120
name: peptidyl-arginine ADP-ribosylation
namespace: biological_process
def:
  "The transfer, from NAD, of ADP-ribose to peptidyl-arginine to form omega-N-(ADP-ribosyl)-L-arginine." [RESID:AA0168]


id: GO:0018121
name: NAD(P)-asparagine ADP-ribosyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: NAD(P)+ + L-asparagine = nicotinamide + N2-(ADP-D-ribosyl)-L-asparagine." [EC:2.4.2.-]


id: GO:0018122
name: peptidyl-asparagine ADP-ribosylation
namespace: biological_process
def:
  "The transfer, from NAD, of ADP-ribose to peptidyl-asparagine to form peptidyl-N4-(ADP-ribosyl)-L-asparagine." [RESID:AA0231]


id: GO:0018123
name: peptidyl-cysteine ADP-ribosylation
namespace: biological_process
def:
  "The transfer, from NAD, of ADP-ribose to peptidyl-cysteine to form peptidyl-S-(ADP-ribosyl)-L-cysteine." [RESID:AA0169]


id: GO:0018124
name: peptide cross-linking via 5'-(N6-L-lysine)-L-topaquinone
namespace: biological_process
def:
  "The cross-linking of the epsilon-amino group of a peptidyl-lysine with peptidyl-topaquinone, a modified tyrosine residue." [RESID:AA0233]


id: GO:0018127
name: NAD(P)-serine ADP-ribosyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: NAD(P)+ + L-serine = nicotinamide + N2-(ADP-D-ribosyl)-L-serine." [EC:2.4.2.-]


id: GO:0018130
name: heterocycle biosynthetic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of heterocyclic compounds, those with a cyclic molecular structure and at least two different atoms in the ring (or rings)." [ISBN:0198547684]


id: GO:0018131
name: oxazole or thiazole biosynthetic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of oxazole or thiazole, five-membered heterocyclic ring structures containing an oxygen and a sulfur, respectively, in the 1-position and a nitrogen in the 3-position." [CHEBI:35790, CHEBI:48901, GOC:curators]


id: GO:0018132
name: peptide cross-linking via L-cysteine oxazolecarboxylic acid
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of a peptidyl serine-peptidyl cysteine cross-link by the condensation of a serine hydroxyl with the carbonyl of the preceding residue and alpha-beta dehydrogenation." [PMID:8895467, RESID:AA0238]


id: GO:0018133
name: peptide cross-linking via L-cysteine oxazolinecarboxylic acid
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of a peptidyl serine-peptidyl cysteine cross-link by the condensation of a serine hydroxyl with the carbonyl of the preceding residue." [RESID:AA0239]


id: GO:0018134
name: peptide cross-linking via glycine oxazolecarboxylic acid
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of a peptidyl serine-peptidyl glycine cross-link by the condensation of a serine hydroxyl with the carbonyl of the preceding residue and alpha-beta dehydrogenation." [RESID:AA0240]


id: GO:0018137
name: peptide cross-linking via glycine thiazolecarboxylic acid
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of a peptidyl cysteine-peptidyl glycine cross-link by the condensation of a cysteine thiol with the carbonyl of the preceding residue and alpha-beta dehydrogenation." [RESID:AA0241]


id: GO:0018138
name: peptide cross-linking via L-serine thiazolecarboxylic acid
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of a peptidyl cysteine-peptidyl serine cross-link by the condensation of a cysteine thiol with the carbonyl of the preceding residue and alpha-beta dehydrogenation." [RESID:AA0242]


id: GO:0018139
name: peptide cross-linking via L-phenylalanine thiazolecarboxylic acid
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of a peptidyl cysteine-peptidyl phenylalanine cross-link by the condensation of a cysteine thiol with the carbonyl of the preceding residue and alpha-beta dehydrogenation." [RESID:AA0243]


id: GO:0018140
name: peptide cross-linking via L-cysteine thiazolecarboxylic acid
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of a peptidyl cysteine-peptidyl cysteine cross-link by the condensation of a cysteine thiol with the carbonyl of the preceding residue and alpha-beta dehydrogenation." [RESID:AA0244]


id: GO:0018141
name: peptide cross-linking via L-lysine thiazolecarboxylic acid
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of a peptidyl cysteine-peptidyl lysine cross-link by the condensation of a cysteine thiol with the carbonyl of the preceding residue and alpha-beta dehydrogenation." [RESID:AA0245]


id: GO:0018145
name: protein-DNA covalent cross-linking via peptidyl-serine
namespace: biological_process
def:
  "The formation of a covalent cross-link between DNA and a peptidyl-serine residue by the formation of O-(phospho-5'-DNA)-L-serine." [RESID:AA0246]


id: GO:0018146
name: keratan sulfate biosynthetic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of keratan sulfate, a glycosaminoglycan with repeat units consisting of beta-1,4-linked D-galactopyranosyl-beta-(1,4)-N-acetyl-D-glucosamine 6-sulfate and with variable amounts of fucose, sialic acid and mannose units; keratan sulfate chains are covalently linked by a glycosidic attachment through the trisaccharide galactosyl-galactosyl-xylose to peptidyl-threonine or serine residues." [ISBN:0198547684, RESID:AA0247]


id: GO:0018147
name: molybdenum incorporation via L-selenocysteinyl molybdenum bis(molybdopterin guanine dinucleotide)
namespace: biological_process
def:
  "The incorporation of molybdenum into a protein via L-selenocysteinyl molybdenum bis(molybdopterin guanine dinucleotide)." [RESID:AA0248]


id: GO:0018148
name: RNA-protein covalent cross-linking via peptidyl-tyrosine
namespace: biological_process
def:
  "The formation of a covalent cross-link between RNA and a peptidyl-tyrosine residue by the formation of O4'-(phospho-5'-RNA)-L-tyrosine." [RESID:AA0249]


id: GO:0018150
name: peptide cross-linking via 3-(3'-L-histidyl)-L-tyrosine
namespace: biological_process
def:
  "The modification of peptidyl-histidine and peptidyl-tyrosine to form a 3-(3'-L-histidyl)-L-tyrosine protein cross-link." [RESID:AA0250]


id: GO:0018151
name: peptide cross-linking via L-histidyl-L-tyrosine
namespace: biological_process
def:
  "The modification of peptidyl-histidine and peptidyl-tyrosine to form a protein cross-link." [GOC:ai]


id: GO:0018152
name: peptide cross-linking via 3'-(1'-L-histidyl)-L-tyrosine
namespace: biological_process
def:
  "The modification of peptidyl-histidine and peptidyl-tyrosine to form a 3'-(1'-L-histidyl)-L-tyrosine protein cross-link." [RESID:AA0270]


id: GO:0018153
name: isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine
namespace: biological_process
def:
  "The formation of an isopeptide cross-link between peptidyl-lysine and peptidyl-glutamine to produce N6-(L-isoglutamyl)-L-lysine." [RESID:AA0124]


id: GO:0018154
name: peptide cross-linking via (2R,6R)-lanthionine
namespace: biological_process
def:
  "The formation of a protein-protein cross-link between peptidyl-serine and peptidyl-cysteine by the synthesis of (2R,6R)-lanthionine (L-lanthionine)." [RESID:AA0110]


id: GO:0018155
name: peptide cross-linking via sn-(2S,6R)-lanthionine
namespace: biological_process
def:
  "The formation of a protein-protein cross-link between peptidyl-serine and peptidyl-cysteine by the synthesis of sn-(2S,6R)-lanthionine (meso-lanthione)." [RESID:AA0111]


id: GO:0018156
name: peptide cross-linking via (2S,3S,6R)-3-methyl-lanthionine
namespace: biological_process
def:
  "The formation of a protein-protein cross-link between peptidyl-threonine and peptidyl-cysteine by the synthesis of (2S,3S,6R)-3-methyl-lanthionine (3-methyl-L-lanthionine)." [RESID:AA0112]


id: GO:0018157
name: peptide cross-linking via an oxazole or thiazole
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of a peptidyl serine-peptidyl glycine, or peptidyl cysteine-peptidyl glycine cross-link by the condensation of the serine hydroxyl or cysteine thiol with the carbonyl of the preceding residue and alpha-beta dehydrogenation." [GOC:jsg]


id: GO:0018160
name: peptidyl-pyrromethane cofactor linkage
namespace: biological_process
def:
  "The covalent binding of a pyrromethane (dipyrrin) cofactor to protein via the sulfur atom of cysteine forming dipyrrolylmethanemethyl-L-cysteine." [CHEBI:30410, RESID:AA0252]


id: GO:0018161
name: dipyrrin biosynthetic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of dipyrrins (pyrromethanes), compounds containing two pyrrole rings linked through a methine, -CH=, group." [http://www.chem.qmw.ac.uk/iupac/class/tetpy.html#03]


id: GO:0018162
name: peptide cross-linking via S-(2-aminovinyl)-3-methyl-D-cysteine
namespace: biological_process
def:
  "The formation of a cross-link between peptidyl-cysteine and peptidyl-threonine via the formation of S-(2-aminovinyl)-3-methyl-D-cysteine." [RESID:AA0253]


id: GO:0018163
name: protein-DNA covalent cross-linking via the 5'-end to peptidyl-tyrosine
namespace: biological_process
def:
  "The formation of a covalent cross-link between DNA and a peptidyl-tyrosine residue by the formation of O4'-(phospho-5'-DNA)-L-tyrosine." [RESID:AA0254]


id: GO:0018164
name: protein-DNA covalent cross-linking via peptidyl-threonine
namespace: biological_process
def:
  "The formation of a covalent cross-link between DNA and a peptidyl-threonine residue by the formation of O-(phospho-5'-DNA)-L-threonine." [RESID:AA0255]


id: GO:0018165
name: peptidyl-tyrosine uridylylation
namespace: biological_process
def:
  "The uridylylation of peptidyl-tyrosine to form peptidyl-O4'-(phospho-5'-uridine)-L-tyrosine, found in glutamine synthetase." [RESID:AA0256]


id: GO:0018166
name: C-terminal protein-tyrosinylation
namespace: biological_process
def:
  "The ATP-dependent addition of a tyrosine residue to the C-terminus of a protein; typically the addition of tyrosine to the C-terminus of detyrosinated alpha-tubulin by the enzyme tubulin-tyrosine ligase." [RESID:AA0257]


id: GO:0018167
name: protein-phycoerythrobilin linkage via phycoerythrobilin-bis-L-cysteine
namespace: biological_process
def:
  "The linkage of the chromophore phycoerythrobilin to phycoerythrin via phycoerythrobilin-bis-L-cysteine." [RESID:AA0259]


id: GO:0018168
name: protein-phycoerythrobilin linkage via S-phycoerythrobilin-L-cysteine
namespace: biological_process
def:
  "The linkage of the chromophore phycoerythrobilin to phycoerythrocyanin via S-phycoerythrobilin-L-cysteine." [RESID:AA0132]


id: GO:0018169
name: ribosomal S6-glutamic acid ligase activity
namespace: molecular_function
def:
  "Catalysis of the posttranslational transfer of one or more glutamic acid residues to the C-terminus of ribosomal protein S6." [GOC:mah, PMID:2570347]


id: GO:0018170
name: C-terminal peptidyl-polyglutamic acid amidation
namespace: biological_process
def:
  "The formation of a C-terminal peptidyl-polyglutamic acid to form a peptidyl-N-L-glutamyl-poly-L-glutamic acid C-terminus." [RESID:AA0261]


id: GO:0018171
name: peptidyl-cysteine oxidation
namespace: biological_process
def:
  "The oxidation of peptidyl-cysteine to peptidyl-L-cysteine sulfinic acid or peptidyl-L-cysteine sulfenic acid." [PMID:9586994, RESID:AA0205, RESID:AA0262]


id: GO:0018172
name: peptidyl-L-3',4',5'-trihydroxyphenylalanine biosynthetic process from peptidyl-tyrosine
namespace: biological_process
def:
  "The modification of protein tyrosine to peptidyl-L-3',4',5'-dihydroxyphenylalanine." [RESID:AA0263]


id: GO:0018173
name: peptidyl-1-thioglycine biosynthetic process from peptidyl-glycine
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of peptidyl-1-thioglycine from other compounds, including peptidyl-glycine." [http://www.uni-marburg.de/mpi/thauer/thauer_res.html, RESID:AA0265]


id: GO:0018178
name: peptidyl-threonine adenylylation
namespace: biological_process
def:
  "The adenylylation of peptidyl-threonine to form peptidyl-O-(phospho-5'-adenosine)-L-threonine." [RESID:AA0267]


id: GO:0018179
name: obsolete peptidyl-cysteine desulfurization
namespace: biological_process
def:
  "OBSOLETE. The desulfurization of peptidyl-L-cysteine to yield L-alanine and elemental sulfur; peptidyl-L-cysteine persulfide is an intermediate." [RESID:AA0269]


id: GO:0018181
name: peptidyl-arginine C5-methylation
namespace: biological_process
def:
  "The methylation of peptidyl-arginine on the carbon 5 (C5) residue to form peptidyl-5-methyl-L-arginine." [GOC:bf, http://www.uni-marburg.de/mpi/thauer/thauer_res.html, RESID:AA0272]


id: GO:0018182
name: protein-heme linkage via 3'-L-histidine
namespace: biological_process
def:
  "The covalent linkage of heme and a protein via 3'-L-histidine (otherwise known as pi-heme-histidine, pros-heme-histidine)." [RESID:AA0276]


id: GO:0018183
name: obsolete enzyme active site formation via S-selenyl-L-cysteine
namespace: biological_process
def:
  "OBSOLETE. The transient selenylation of peptidyl-cysteine to form S-selenyl-L-cysteine." [RESID:AA0277]


id: GO:0018185
name: poly-N-methyl-propylamination
namespace: biological_process
def:
  "The modification of peptidyl-lysine by the addition of an N6-propylamino and of propylmethylamino units, forming N6-(propylamino-poly(propylmethylamino)-propyldimethylamine)-L-lysine, typical of the silicate binding protein silaffin." [RESID:AA0278]


id: GO:0018187
name: molybdenum incorporation via L-cysteinyl molybdopterin guanine dinucleotide
namespace: biological_process
def:
  "The incorporation of molybdenum into a protein by L-cysteinyl molybdopterin guanine dinucleotide." [RESID:AA0281]


id: GO:0018188
name: peptidyl-proline di-hydroxylation
namespace: biological_process
def:
  "The modification of peptidyl-proline to form trans-2,3-cis-3,4-dihydroxy-L-proline." [RESID:AA0282]


id: GO:0018189
name: pyrroloquinoline quinone biosynthetic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of the cofactor pyrroloquinoline quinone (PQQ); it is synthesized from a small peptide containing tyrosine and glutamic acid; these amino acids in the peptide are multiply cross-linked and the rest of the peptide is removed." [PMID:7665488, RESID:AA0283]


id: GO:0018190
name: protein octanoylation
namespace: biological_process
def:
  "The modification of a protein amino acid by formation of an ester or amide with octanoic acid." [GOC:jsg]


id: GO:0018191
name: peptidyl-serine octanoylation
namespace: biological_process
def:
  "The octanoylation of peptidyl-serine to form peptidyl-O3-octanoyl-L-serine, typical of the protein ghrelin." [PMID:10604470, RESID:AA0290]


id: GO:0018192
name: enzyme active site formation via cysteine modification to L-cysteine persulfide
namespace: biological_process
def:
  "The formation of an enzyme active site via modification of peptidyl-cysteine to peptidyl-L-cysteine persulfide." [PMID:11592406, RESID:AA0269]


id: GO:0018220
name: peptidyl-threonine palmitoylation
namespace: biological_process
def:
  "The covalent attachment of a palmitoyl group to an oxygen (O) atom in a threonine residue to form peptidyl-O-palmitoyl-L-threonine." [RESID:AA0079]


id: GO:0018221
name: peptidyl-serine palmitoylation
namespace: biological_process
def:
  "The covalent attachment of a palmitoyl group to an oxygen (O) atom in a serine residue to form peptidyl-O-palmitoyl-L-serine." [RESID:AA0080]


id: GO:0018222
name: peptidyl-L-cysteine methyl disulfide biosynthetic process from peptidyl-cysteine
namespace: biological_process
def:
  "The modification of peptidyl-cysteine to form peptidyl-L-cysteine methyl disulfide." [RESID:AA0101]


id: GO:0018226
name: peptidyl-S-farnesyl-L-cysteine biosynthetic process from peptidyl-cysteine
namespace: biological_process
def:
  "The modification of peptidyl-cysteine to form peptidyl-S-farnesyl-L-cysteine; formation of S-farnesycysteine may be coupled with subsequent cleavage of a carboxy-terminal tripeptide for the CXXX motif and methyl esterification of the farnesylated cysteine; the residue may be found at the first position in the sequence motif C-X-X-(SAQCMT)* where the second and third positions are usually aliphatic." [RESID:AA0102]


id: GO:0018227
name: peptidyl-S-12-hydroxyfarnesyl-L-cysteine biosynthetic process from peptidyl-cysteine
namespace: biological_process
def:
  "The modification of peptidyl-cysteine to form S-12-hydroxyfarnesyl-L-cysteine; formation of S-farnesycysteine may be coupled with subsequent cleavage of a carboxy-terminal tripeptide for the CXXX motif and methyl esterification of the farnesylated cysteine." [RESID:AA0103]


id: GO:0018228
name: peptidyl-S-geranylgeranyl-L-cysteine biosynthetic process from peptidyl-cysteine
namespace: biological_process
def:
  "The modification of peptidyl-cysteine to form peptidyl-S-geranylgeranylcysteine; formation of S-geranylgeranyl-L-cysteine may be coupled with subsequent cleavage of a carboxy-terminal tripeptide for the CAAX motif and methyl esterification of the geranylgeranylated cysteine; methyl esterification but not cleavage occurs for the CXC motif. For the type II geranylgeranyltransferase the residue may be found at the first and final positions in the sequence motif C-X-C* or at the final position in the sequence motif C-C*. These motifs are necessary but not sufficient for modification." [RESID:AA0104]


id: GO:0018229
name: peptidyl-L-cysteine methyl ester biosynthetic process from peptidyl-cysteine
namespace: biological_process
def:
  "The modification of a C-terminal peptidyl-cysteine to form peptidyl-L-cysteine methyl ester." [RESID:AA0105]


id: GO:0018230
name: peptidyl-L-cysteine S-palmitoylation
namespace: biological_process
def:
  "The covalent attachment of a palmitoyl group to a sulfur (S) atom within a cysteine residue to form peptidyl-S-palmitoyl-L-cysteine." [RESID:AA0106]


id: GO:0018231
name: peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine
namespace: biological_process
def:
  "The modification of peptidyl-cysteine to form peptidyl-S-diacylglycerol-L-cysteine; the oleate and palmitate actually represent mixtures of saturated (generally at 3') and unsaturated (generally at 2') fatty acids." [RESID:AA0107]


id: GO:0018232
name: peptide cross-linking via S-(L-isoglutamyl)-L-cysteine
namespace: biological_process
def:
  "The modification of peptidyl-glutamine and peptidyl-cysteine to form a S-(L-isoglutamyl)-L-cysteine protein cross-link." [RESID:AA0108]


id: GO:0018233
name: peptide cross-linking via 2'-(S-L-cysteinyl)-L-histidine
namespace: biological_process
def:
  "The modification of peptidyl-histidine and peptidyl-cysteine to form a 2'-(S-L-cysteinyl)-L-histidine protein cross-link." [RESID:AA0109]


id: GO:0018234
name: peptide cross-linking via 3'-(S-L-cysteinyl)-L-tyrosine
namespace: biological_process
def:
  "The thioether cross-linking of a cysteine residue to a tyrosine residue to form 3'-(S-L-cysteinyl)-L-tyrosine, found in galactose oxidase." [RESID:AA0113]


id: GO:0018237
name: urease activator activity
namespace: molecular_function
def:
  "Increases the activity of urease by promoting the incorporation of nickel into the active site." [GOC:mah, PMID:16244137]


id: GO:0018240
name: protein S-linked glycosylation via cysteine
namespace: biological_process
def:
  "The glycosylation of protein via the sulfur atom of peptidyl-cysteine, forming S-glycosyl-L-cysteine." [RESID:AA0152]


id: GO:0018241
name: protein O-linked glycosylation via hydroxylysine
namespace: biological_process
def:
  "The glycosylation of protein via the O5 atom of peptidyl-hydroxylysine, forming O5-glycosyl-L-hydroxylysine; the most common form is galactosyl hydroxylysine." [RESID:AA0153]


id: GO:0018242
name: protein O-linked glycosylation via serine
namespace: biological_process
def:
  "The glycosylation of protein via the O3 atom of peptidyl-serine, forming O3-glycosyl-L-serine; the most common forms are N-acetylgalactosaminyl, mannosyl, galactosyl, and xylosyl serine." [RESID:AA0154]


id: GO:0018243
name: protein O-linked glycosylation via threonine
namespace: biological_process
def:
  "The glycosylation of protein via the O3 atom of peptidyl-threonine, forming O3-glycosyl-L-threonine; the most common forms are N-acetylgalactosaminyl, mannosyl, and galactosyl threonine." [RESID:AA0155]


id: GO:0018244
name: protein N-linked glycosylation via tryptophan
namespace: biological_process
def:
  "The glycosylation of protein via peptidyl-tryptophan, 1'-glycosyl-L-tryptophan; results in the formation of an (S)-2-amino-3-(1-D-mannopyranosyloxy-1H-indol-3-yl)propanoic acid residue." [RESID:AA0156]


id: GO:0018245
name: protein O-linked glycosylation via tyrosine
namespace: biological_process
def:
  "The glycosylation of protein via the O4' atom of peptidyl-tyrosine, O4'-glycosyl-L-tyrosine; the carbohydrate is glucose, the origin for glycogen." [RESID:AA0157]


id: GO:0018247
name: protein-phosphoribosyl dephospho-coenzyme A linkage
namespace: biological_process
def:
  "The linkage of phosphoribosyl dephospho-coenzyme A to protein via peptidyl-serine, to form O-(phosphoribosyl dephospho-coenzyme A)-L-serine; it is uncertain whether the phosphoribosyl glycosidic attachment to the dephospho-coenzyme A is alpha or beta, and through the 2' or the 3' position." [RESID:AA0167]


id: GO:0018248
name: enzyme active site formation via peptidyl cysteine sulfation
namespace: biological_process
def:
  "The formation of an enzyme active site via transient sulfation of peptidyl-cysteine to form S-sulfo-L-cysteine." [RESID:AA0171]


id: GO:0018250
name: peptidyl-dehydroalanine biosynthetic process from peptidyl-tyrosine or peptidyl-serine
namespace: biological_process
def:
  "The formation of peptidyl-dehydroalanine from either peptidyl-tyrosine by phenyl transfer, or from peptidyl-serine, which is coupled with the formation of 5-imidazolinone by the two neighboring residues, produces an 4-methylidene-imidazole-5-one active site of some amino acid ammonia-lyases; the 4-methylidene-imidazole-5-one, is formed autocatalytically by cyclization and dehydration of the sequence ASG." [RESID:AA0181]


id: GO:0018251
name: peptidyl-tyrosine dehydrogenation
namespace: biological_process
def:
  "The oxidation of the C alpha-C beta bond of peptidyl-tyrosine to form peptidyl-dehydrotyrosine coupled with cyclization of neighboring residues." [RESID:AA0183]


id: GO:0018252
name: peptide cross-linking via L-seryl-5-imidazolinone glycine
namespace: biological_process
def:
  "The formation of the green fluorescent protein chromophore cross-link from the alpha-carboxyl carbon of residue n, a serine, to the alpha-amino nitrogen of residue n+2, a glycine, and a dehydration to form a double bond to the alpha-amino nitrogen of residue n+1. This cross-linking is coupled with a dehydrogenation of residue n+1 to form a double bond between the alpha and beta carbons." [RESID:AA0184]


id: GO:0018253
name: peptide cross-linking via 5-imidazolinone glycine
namespace: biological_process
def:
  "The formation of a protein active site cross-link from the alpha-carboxyl carbon of residue n, an alanine, serine or cysteine, to the alpha-amino nitrogen of residue n+2, a glycine, and a dehydration to form a double bond to the alpha-amino nitrogen of residue n+1. This cross-linking is coupled with an oxidation of residue n+1 to form an active aldehyde." [RESID:AA0184, RESID:AA0187, RESID:AA0188]


id: GO:0018254
name: peptidyl-tyrosine adenylylation
namespace: biological_process
def:
  "The adenylylation of peptidyl-tyrosine to form peptidyl-O4'-(phospho-5'-adenosine)-L-tyrosine." [RESID:AA0203]


id: GO:0018255
name: peptide cross-linking via S-glycyl-L-cysteine
namespace: biological_process
def:
  "The formation of S-(peptidyl-glycyl)-peptidyl-cysteine cross-links by the formation of a thiolester between cysteine and the carboxy-terminal glycine of ubiquitin and other proteins." [GOC:jh2, RESID:AA0206]


id: GO:0018258
name: protein O-linked glycosylation via hydroxyproline
namespace: biological_process
def:
  "The glycosylation of proteins via 04 atom of hydroxyproline to form O4-glycosyl-L-hydroxyproline; the most common form is arabinofuranosyl-4-proline." [RESID:AA0212]


id: GO:0018259
name: RNA-protein covalent cross-linking via peptidyl-serine
namespace: biological_process
def:
  "The formation of a covalent cross-link between RNA and a peptidyl-serine residue by the formation of O-(phospho-5'-5NA)-L-serine." [RESID:AA0213]


id: GO:0018261
name: peptidyl-lysine guanylylation
namespace: biological_process
def:
  "The guanylylation of peptidyl-lysine to form peptidyl-N6-(phospho-5'-guanosine)-L-lysine." [RESID:AA0228]


id: GO:0018262
name: isopeptide cross-linking
namespace: biological_process
def:
  "The formation of a covalent cross-link between or within peptide chains, where either the amino group or the carboxyl group, or both, are not attached to the alpha carbon." [GOC:jsg]


id: GO:0018263
name: isopeptide cross-linking via N-(L-isoaspartyl)-L-cysteine
namespace: biological_process
def:
  "The formation of an isopeptide cross-link between peptidyl-asparagine and peptidyl-cysteine to produce N-(L-isoaspartyl)-L-cysteine." [RESID:AA0216]


id: GO:0018264
name: isopeptide cross-linking via N-(L-isoaspartyl)-glycine
namespace: biological_process
def:
  "The formation of an isopeptide cross-link between peptidyl-asparagine and peptidyl-glycine to produce N-(L-isoaspartyl)-glycine." [RESID:AA0126]


id: GO:0018265
name: GPI anchor biosynthetic process via N-asparaginyl-glycosylphosphatidylinositolethanolamine
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of a C-terminal peptidyl-asparagine ethanolamide-linked glycosylphosphatidylinositol (GPI) anchor following hydrolysis of a asparaginyl-peptide bond in the carboxy-terminal region of a membrane-associated protein." [RESID:AA0158]


id: GO:0018266
name: GPI anchor biosynthetic process via N-aspartyl-glycosylphosphatidylinositolethanolamine
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of a C-terminal peptidyl-aspartic acid ethanolamide-linked glycosylphosphatidylinositol (GPI) anchor following hydrolysis of a aspartyl-peptide bond in the carboxy-terminal region of a membrane-associated protein." [RESID:AA0159]


id: GO:0018267
name: GPI anchor biosynthetic process via N-cysteinyl-glycosylphosphatidylinositolethanolamine
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of a C-terminal peptidyl-cysteine ethanolamide-linked glycosylphosphatidylinositol (GPI) anchor following hydrolysis of a cysteinyl-peptide bond in the carboxy-terminal region of a membrane-associated protein." [RESID:AA0160]


id: GO:0018268
name: GPI anchor biosynthetic process via N-glycyl-glycosylphosphatidylinositolethanolamine
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of a C-terminal peptidyl-glycine ethanolamide-linked glycosylphosphatidylinositol (GPI) anchor following hydrolysis of a glycyl-peptide bond in the carboxy-terminal region of a membrane-associated protein." [RESID:AA0161]


id: GO:0018269
name: GPI anchor biosynthetic process via N-seryl-glycosylphosphatidylinositolethanolamine
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of a C-terminal peptidyl-serine ethanolamide-linked glycosylphosphatidylinositol (GPI) anchor following hydrolysis of a seryl-peptide bond in the carboxy-terminal region of a membrane-associated protein." [RESID:AA0162]


id: GO:0018270
name: GPI anchor biosynthetic process via N-alanyl-glycosylphosphatidylinositolethanolamine
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of a C-terminal peptidyl-alanine ethanolamide-linked glycosylphosphatidylinositol (GPI) anchor following hydrolysis of an alanyl-peptide bond in the carboxy-terminal region of a membrane-associated protein." [RESID:AA0163]


id: GO:0018274
name: peptide cross-linking via L-lysinoalanine
namespace: biological_process
def:
  "The modification of peptidyl-lysine and peptidyl-serine to form a (2Xi,9S)-L-lysinoalanine cross-link." [RESID:AA0123]


id: GO:0018275
name: N-terminal peptidyl-cysteine acetylation
namespace: biological_process
def:
  "The acetylation of the N-terminal cysteine of proteins to form the derivative N-acetyl-L-cysteine." [RESID:AA0043]


id: GO:0018276
name: isopeptide cross-linking via N6-glycyl-L-lysine
namespace: biological_process
def:
  "The formation of an isopeptide cross-link between peptidyl-lysine and peptidyl-glycine to produce N6-glycyl-L-lysine. This is distinct from the formation of the thiolester intermediate, which occurs during ubiquitination." [RESID:AA0125]


id: GO:0018278
name: N-terminal peptidyl-threonine deamination
namespace: biological_process
def:
  "The deamination of N-terminal peptidyl-threonine to form peptidyl-2-oxobutanoic acid." [RESID:AA0129]


id: GO:0018279
name: protein N-linked glycosylation via asparagine
namespace: biological_process
def:
  "The glycosylation of protein via the N4 atom of peptidyl-asparagine forming N4-glycosyl-L-asparagine; the most common form is N-acetylglucosaminyl asparagine; N-acetylgalactosaminyl asparagine and N4 glucosyl asparagine also occur. This modification typically occurs in extracellular peptides with an N-X-(ST) motif. Partial modification has been observed to occur with cysteine, rather than serine or threonine, in the third position; secondary structure features are important, and proline in the second or fourth positions inhibits modification." [GOC:jsg, RESID:AA0151, RESID:AA0420, RESID:AA0421]


id: GO:0018280
name: protein S-linked glycosylation
namespace: biological_process
def:
  "A protein glycosylation process in which a carbohydrate or carbohydrate derivative unit is added to a protein via a sulfur atom of a peptidyl-amino-acid such as cysteine or methionine." [GOC:ai, GOC:jsg, GOC:pr]


id: GO:0018281
name: GSI anchor biosynthetic process via N-seryl-glycosylsphingolipidinositolethanolamine
namespace: biological_process
def:
  "The formation of a C-terminal peptidyl-serine ethanolamide-linked glycosylsphingolipidinositol (GSI) anchor following hydrolysis of a seryl-peptide bond in the carboxy-terminal region of a membrane-associated protein." [RESID:AA0166]


id: GO:0018282
name: metal incorporation into metallo-sulfur cluster
namespace: biological_process
def:
  "The formation of a cluster of several metal atoms, including iron, nickel, molybdenum, vanadium, or copper, with one or more bridging (mu-bond) sulfur atoms; amino acids residues in proteins that may ligate the metal sulfur cluster are cysteine, histidine, aspartate, glutamate, serine and cysteine persulfide." [GOC:jsg]


id: GO:0018284
name: iron incorporation into protein via tetrakis-L-cysteinyl iron
namespace: biological_process
def:
  "The incorporation of iron into a protein via tetrakis-L-cysteinyl iron (there is no exogenous sulfur, so this modification by itself does not produce an iron-sulfur protein)." [RESID:AA0136]


id: GO:0018285
name: iron incorporation into iron-sulfur cluster via tetrakis-L-cysteinyl diiron disulfide
namespace: biological_process
def:
  "The incorporation of iron into a 2Fe-2S iron-sulfur cluster via tetrakis-L-cysteinyl diiron disulfide." [RESID:AA0137]


id: GO:0018286
name: obsolete iron incorporation into iron-sulfur cluster via hexakis-L-cysteinyl triiron trisulfide
namespace: biological_process
def:
  "OBSOLETE. The incorporation of iron into a 3Fe-3S iron-sulfur cluster via hexakis-L-cysteinyl triiron trisulfide. The three-iron three-sulfur cluster probably does not exist except as an intermediate form." [RESID:AA0138]


id: GO:0018287
name: iron incorporation into iron-sulfur cluster via tris-L-cysteinyl triiron tetrasulfide
namespace: biological_process
def:
  "The incorporation of iron into a 3Fe-4S iron-sulfur cluster via tris-L-cysteinyl triiron tetrasulfide." [RESID:AA0139]


id: GO:0018288
name: iron incorporation into iron-sulfur cluster via tetrakis-L-cysteinyl tetrairon tetrasulfide
namespace: biological_process
def:
  "The incorporation of iron into a 4Fe-4S iron-sulfur cluster via tetrakis-L-cysteinyl tetrairon tetrasulfide." [RESID:AA0140]


id: GO:0018290
namespace: biological_process
name:
  iron and molybdenum incorporation into iron-molybdenum-sulfur cluster via L-cysteinyl homocitryl molybdenum-heptairon-nonasulfide

def:
  "The incorporation of iron and molybdenum into a Mo-7Fe-8S iron-molybdenum-sulfur cluster via L-cysteinyl homocitryl molybdenum-heptairon-nonasulfide, found in nitrogenase." [RESID:AA0141]


id: GO:0018293
name: protein-FAD linkage
namespace: biological_process
def:
  "The formation of a linkage between a protein amino acid and flavin-adenine dinucleotide (FAD)." [GOC:ai]


id: GO:0018299
namespace: biological_process
name:
  iron incorporation into the Rieske iron-sulfur cluster via bis-L-cysteinyl bis-L-histidino diiron disulfide

def:
  "The incorporation of iron into a Rieske 4Fe-4S iron-sulfur cluster via bis-L-cysteinyl bis-L-histidino diiron disulfide." [RESID:AA0225]


id: GO:0018300
name: obsolete iron incorporation into iron-sulfur cluster via hexakis-L-cysteinyl hexairon hexasulfide
namespace: biological_process
def:
  "OBSOLETE. The incorporation of iron into a 6Fe-6S cluster by hexakis-L-cysteinyl hexairon hexasulfide." [RESID:AA0226]


id: GO:0018301
namespace: biological_process
name:
  iron incorporation into iron-sulfur cluster via tris-L-cysteinyl-L-cysteine persulfido-bis-L-glutamato-L-histidino tetrairon

def:
  "The incorporation of iron into an iron-sulfur cluster by tris-L-cysteinyl-L-cysteine persulfido-bis-L-glutamato-L-histidino tetrairon." [RESID:AA0268]


id: GO:0018302
namespace: biological_process
name:
  iron incorporation into iron-sulfur cluster via tris-L-cysteinyl-L-N1'-histidino tetrairon tetrasulfide

def:
  "The incorporation of iron into a 4Fe-4S iron-sulfur cluster via tris-L-cysteinyl-L-N1'-histidino tetrairon tetrasulfide." [RESID:AA0284]


id: GO:0018303
namespace: biological_process
name:
  iron incorporation into iron-sulfur cluster via tris-L-cysteinyl-L-N3'-histidino tetrairon tetrasulfide

def:
  "The incorporation of iron into a 4Fe-4S iron-sulfur cluster via tris-L-cysteinyl-L-N3'-histidino tetrairon tetrasulfide." [RESID:AA0285]


id: GO:0018304
name: iron incorporation into iron-sulfur cluster via tris-L-cysteinyl-L-aspartato tetrairon tetrasulfide
namespace: biological_process
def:
  "The incorporation of iron into a 4Fe-4S iron-sulfur cluster via tris-L-cysteinyl-L-aspartato tetrairon tetrasulfide." [RESID:AA0286]


id: GO:0018305
name: iron incorporation into iron-sulfur cluster via tris-L-cysteinyl-L-serinyl tetrairon tetrasulfide
namespace: biological_process
def:
  "The incorporation of iron into a 4Fe-4S iron-sulfur cluster via tris-L-cysteinyl-L-serinyl tetrairon tetrasulfide." [RESID:AA0288]


id: GO:0018306
namespace: biological_process
name:
  iron incorporation into iron-sulfur cluster via bis-L-cysteinyl-L-N3'-histidino-L-serinyl tetrairon tetrasulfide

def:
  "The incorporation of iron into a 4Fe-4S iron-sulfur cluster via bis-L-cysteinyl-L-N3'-histidino-L-serinyl tetrairon tetrasulfide." [RESID:AA0289]


id: GO:0018308
name: obsolete enzyme active site formation via N6-pyruvic acid 2-iminyl-L-lysine
namespace: biological_process
def:
  "OBSOLETE. The transient modification of lysine by pyruvate to form N6-pyruvic acid 2-iminyl-L-lysine, found in the active site of dihydrodipicolinate synthase." [PMID:1463470, RESID:AA0287]


id: GO:0018309
name: protein-FMN linkage
namespace: biological_process
def:
  "The formation of a linkage between a protein amino acid and flavin mononucleotide (FMN)." [GOC:mah]


id: GO:0018311
name: peptidyl-N4-hydroxymethyl-L-asparagine biosynthetic process from peptidyl-asparagine
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of N4-hydroxymethyl-L-asparagine from other compounds, including peptidyl-asparagine." [RESID:AA0236]


id: GO:0018312
name: peptidyl-serine ADP-ribosylation
namespace: biological_process
def:
  "The transfer, from NAD, of ADP-ribose to peptidyl-serine to form peptidyl-O-(ADP-ribosyl)-L-serine." [RESID:AA0237]


id: GO:0018313
name: peptide cross-linking via L-alanyl-5-imidazolinone glycine
namespace: biological_process
def:
  "The formation of a protein active site cross-link from the alpha-carboxyl carbon of residue N, an alanine, to the alpha-amino nitrogen of residue N+2, a glycine, coupled with the formation of a double bond to the alpha-amino nitrogen of residue N+1 which loses one hydrogen, and the loss of a molecule of water." [RESID:AA0187]


id: GO:0018314
name: obsolete protein-pyrroloquinoline-quinone linkage
namespace: biological_process
def:
  "OBSOLETE. The covalent cross-linking of pyrroloquinoline-quinone to peptidyl-glutamic acid and peptidyl-tyrosine." [PMID:7665488, RESID:AA0283]


id: GO:0018316
name: peptide cross-linking via L-cystine
namespace: biological_process
def:
  "The oxidation of two peptidyl-cysteine residues to form a peptidyl-L-cystine (dicysteine) in which segments of peptide chain are linked by a disulfide bond; the cross-link may be between different or the same peptide chain." [RESID:AA0025]


id: GO:0018321
name: protein glucuronylation
namespace: biological_process
def:
  "The modification of a protein by amino acid glucuronylation, the addition of a glucuronate group, the uronic acid derived from glucose." [GOC:ai, GOC:pr]


id: GO:0018324
name: enzyme active site formation via L-cysteine sulfenic acid
namespace: biological_process
def:
  "The oxidation of peptidyl-cysteine to form peptidyl-L-cysteine sulfenic acid, found in the active site of NADH peroxidase, nitrile hydratase, and peptide methionine sulfoxide reductase." [PMID:2501303, RESID:AA0205]


id: GO:0018327
name: enzyme active site formation via 1'-phospho-L-histidine
namespace: biological_process
def:
  "The transient phosphorylation of peptidyl-histidine to form 1'-phospho-L-histidine (otherwise known as tau-phosphohistidine, tele-phosphohistidine)." [RESID:AA0035]


id: GO:0018328
name: enzyme active site formation via 3'-phospho-L-histidine
namespace: biological_process
def:
  "The transient phosphorylation of peptidyl-histidine to form 3'-phospho-L-histidine (otherwise known as pi-phosphohistidine, pros-phosphohistidine)." [RESID:AA0036]


id: GO:0018329
name: enzyme active site formation via N6-(phospho-5'-adenosine)-L-lysine
namespace: biological_process
def:
  "The transient adenylylation of lysine to form N6-(phospho-5'-adenosine)-L-lysine, found in the active site of DNA ligase and RNA ligase." [RESID:AA0227]


id: GO:0018330
name: enzyme active site formation via N6-(phospho-5'-guanosine)-L-lysine
namespace: biological_process
def:
  "The transient guanylylation of lysine to form N6-(phospho-5'-guanosine)-L-lysine, found in the guanylyltransferase active site of mRNA capping enzyme." [RESID:AA0228]


id: GO:0018332
name: enzyme active site formation via O-(phospho-5'-adenosine)-L-threonine
namespace: biological_process
def:
  "The transient adenylylation of threonine to form N6-(phospho-5'-adenosine)-L-threonine, found in the active site of bovine phosphodiesterase I." [RESID:AA0267]


id: GO:0018335
name: protein succinylation
namespace: biological_process
def:
  "The modification of a protein by the addition of a succinyl group (CO-CH2-CH2-CO) to an amino acid residue." [CHEBI:37952, GOC:bf]


id: GO:0018339
name: peptidyl-L-beta-methylthioaspartic acid biosynthetic process from peptidyl-aspartic acid
namespace: biological_process
def:
  "The modification of peptidyl-aspartic acid to form peptidyl-L-beta-methylthioaspartic acid, typical of bacterial ribosomal protein S12." [RESID:AA0232]


id: GO:0018340
name: peptidyl-O-(sn-1-glycerophosphoryl)-L-serine biosynthetic process from peptidyl-serine
namespace: biological_process
def:
  "The modification of peptidyl-serine to peptidyl-O-(sn-1-glycerophosphoryl)-L-serine." [RESID:AA0264]


id: GO:0018341
name: peptidyl-lysine modification to peptidyl-N6-pyruvic acid 2-iminyl-L-lysine
namespace: biological_process
def:
  "The modification of peptidyl-lysine to form peptidyl-N6-pyruvic acid 2-iminyl-L-lysine." [PSI-MOD:00292]


id: GO:0018342
name: protein prenylation
namespace: biological_process
def:
  "The covalent attachment of a prenyl group to a protein; geranyl, farnesyl, or geranylgeranyl groups may be added." [GOC:di, ISBN:0198506732]


id: GO:0018353
name: protein-phycocyanobilin linkage via S-phycocyanobilin-L-cysteine
namespace: biological_process
def:
  "The linkage of the chromophore phycocyanobilin to phycocyanin or allophycocyanin via S-phycocyanobilin-L-cysteine." [RESID:AA0131]


id: GO:0018355
namespace: biological_process
name:
  protein-phosphoribosyl dephospho-coenzyme A linkage via O-(phosphoribosyl dephospho-coenzyme A)-L-serine

def:
  "The formation of a protein-phosphoribosyl dephospho-coenzyme A linkage via O-(phosphoribosyl dephospho-coenzyme A)-L-serine." [RESID:AA00167]


id: GO:0018356
name: protein-phycobiliviolin linkage via S-phycobiliviolin-L-cysteine
namespace: biological_process
def:
  "The linkage of the chromophore phycobiliviolin to phycoerythrocyanin via S-phycobiliviolin-L-cysteine." [RESID:AA0258]


id: GO:0018357
name: protein-phycourobilin linkage via phycourobilin-bis-L-cysteine
namespace: biological_process
def:
  "The linkage of the chromophore phycourobilin to phycoerythrins via phycourobilin-bis-L-cysteine." [RESID:AA0260]


id: GO:0018358
name: protein-phytochromobilin linkage via S-phytochromobilin-L-cysteine
namespace: biological_process
def:
  "The linkage of the chromophore phytochromobilin to phycocyanin or allophycocyanin via S-phytochromobilin-L-cysteine." [RESID:AA0133]


id: GO:0018361
name: peptidyl-glutamine 2-methylation
namespace: biological_process
def:
  "The methylation of glutamine to form 2-methyl-L-glutamine." [http://www.uni-marburg.de/mpi/thauer/thauer_res.html, RESID:AA0273]


id: GO:0018362
name: peroxidase-heme linkage via dihydroxyheme-L-aspartyl ester-L-glutamyl ester
namespace: biological_process
def:
  "The covalent linkage of heme to peroxidase via dihydroxyheme-L-aspartyl ester-L-glutamyl ester." [RESID:AA0279]


id: GO:0018363
name: peroxidase-heme linkage via dihydroxyheme-L-aspartyl ester-L-glutamyl ester-L-methionine sulfonium
namespace: biological_process
def:
  "The covalent linkage of heme to peroxidase via dihydroxyheme-L-aspartyl ester-L-glutamyl ester-L-methionine sulfonium." [RESID:AA0280]


id: GO:0018366
name: chiral amino acid racemization
namespace: biological_process
def:
  "The formation of a mixture of the two possible enantiomers from the D- or L-enantiomer of a chiral amino acid." [GOC:jsg, ISBN:0198506732]


id: GO:0018376
name: peptidyl-asparagine hydroxylation to form L-erythro-beta-hydroxyasparagine
namespace: biological_process
def:
  "The hydroxylation of peptidyl-asparagine to form peptidyl-L-erythro-beta-hydroxyasparagine; catalyzed by peptide-aspartate beta-dioxygenase (EC:1.14.11.16)." [RESID:AA0026]


id: GO:0018379
name: cytochrome c-heme linkage via heme-bis-L-cysteine
namespace: biological_process
def:
  "The linkage of cytochromes and other heme proteins to heme via heme-bis-L-cysteine." [RESID:AA0134]


id: GO:0018386
name: N-terminal peptidyl-cysteine condensation with pyruvate to form N-pyruvic acid 2-iminyl-L-cysteine
namespace: biological_process
def:
  "The condensation of pyruvate through the 2-oxo group with the N-terminal cysteine of proteins to form the derivative N-pyruvic acid 2-iminyl-L-cysteine." [RESID:AA0274]


id: GO:0018387
name: N-terminal peptidyl-amino acid deamination to pyruvic acid
namespace: biological_process
def:
  "The oxidative deamination of N-terminal peptidyl-cysteine, or peptidyl-serine, to form pyruvic acid with an amide bond between its 1-carboxyl group and the N-terminal residue." [RESID:AA0127]


id: GO:0018388
name: N-terminal peptidyl-valine condensation with pyruvate to form N-pyruvic acid 2-iminyl-L-valine
namespace: biological_process
def:
  "The condensation of pyruvate through the 2-oxo group with the N-terminal valine of proteins to form the derivative N-pyruvic acid 2-iminyl-L-valine." [RESID:AA0275]


id: GO:0018389
name: N-terminal peptidyl-valine deamination
namespace: biological_process
def:
  "The deamination of the N-terminal valine residue of a protein to form isobutyrate." [GOC:ma, GOC:mah]


id: GO:0018390
namespace: biological_process
name:
  peptidyl-L-glutamic acid 5-methyl ester biosynthetic process from peptidyl-glutamic acid or peptidyl-glutamine

def:
  "The methyl esterification of peptidyl-glutamic acid or peptidyl-glutamine to form the derivative glutamic acid 5-methyl ester." [RESID:AA0072]


id: GO:0018391
name: C-terminal peptidyl-glutamic acid tyrosinylation
namespace: biological_process
def:
  "The ATP-dependent addition of a tyrosine residue to a glutamic acid residue at the C-terminus of a protein." [GOC:mah]


id: GO:0018392
name: glycoprotein 3-alpha-L-fucosyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: N(4)-{N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)]-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl}-L-asparagine + GDP-L-fucose = N(4)-{N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)]-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl}-L-asparagine + GDP + H(+)." [EC:2.4.1.214, RHEA:24447]


id: GO:0018400
name: peptidyl-proline hydroxylation to 3-hydroxy-L-proline
namespace: biological_process
def:
  "The modification of peptidyl-proline to form 3-hydroxy-L-proline; catalyzed by procollagen-proline 3-dioxygenase." [RESID:AA0029]


id: GO:0018401
name: peptidyl-proline hydroxylation to 4-hydroxy-L-proline
namespace: biological_process
def:
  "The modification of peptidyl-proline to form 4-hydroxy-L-proline; catalyzed by procollagen-proline,2-oxoglutarate-4-dioxygenase." [RESID:AA0030]


id: GO:0018402
namespace: biological_process
name:
  protein-chondroitin sulfate linkage via chondroitin sulfate D-glucuronyl-D-galactosyl-D-galactosyl-D-xylosyl-L-serine

def:
  "Chondroitin sulfate components are covalently linked to a core glycoprotein via O-glycosidic linkages between xylose and serine residues." [RESID:AA0208]


id: GO:0018403
namespace: biological_process
name:
  protein-dermatan sulfate linkage via dermatan 4-sulfate D-glucuronyl-D-galactosyl-D-galactosyl-D-xylosyl-L-serine

def:
  "Dermatan sulfate components are covalently linked to a core glycoprotein via O-glycosidic linkages between xylose and serine residues." [PMID:7338506, RESID:AA0209]


id: GO:0018404
namespace: biological_process
name:
  protein-heparan sulfate linkage via heparan sulfate D-glucuronyl-D-galactosyl-D-galactosyl-D-xylosyl-L-serine

def:
  "Heparan sulfate components are covalently linked to a core glycoprotein via O-glycosidic linkages between xylose and serine residues." [RESID:AA0210]


id: GO:0018405
namespace: biological_process
name:
  protein-keratan sulfate linkage via keratan sulfate D-glucuronyl-D-galactosyl-D-galactosyl-D-xylosyl-L-threonine

def:
  "Keratan sulfate components are covalently linked to a core glycoprotein via O-glycosidic linkages between xylose and threonine residues." [RESID:AA0247]


id: GO:0018406
name: protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan
namespace: biological_process
def:
  "The glycosylation of a peptidyl-tryptophan residue by the transfer of alpha-mannopyranose from dolichyl-activated mannose to the indole ring." [PMID:7947762, PMID:9450955, RESID:AA0217]


id: GO:0018407
name: peptidyl-thyronine iodination to form 3',3'',5'-triiodo-L-thyronine
namespace: biological_process
def:
  "The iodination of peptidyl-thyronine to form peptidyl-3',3'',5'-triiodo-L-thyronine (triiodothyronine)." [RESID:AA0177]


id: GO:0018408
name: peptidyl-thyronine iodination to form 3',3'',5',5''-tetraiodo-L-thyronine
namespace: biological_process
def:
  "The iodination of peptidyl-thyronine to form peptidyl-3',3'',5',5''-tetraiodo-L-thyronine (L-thyroxine)." [RESID:AA0178]


id: GO:0018413
name: peptidyl-serine O-glucuronidation
namespace: biological_process
def:
  "The O-glucuronidation of peptidyl-serine to form peptidyl-O3-D-glucuronyl-L-serine." [RESID:AA0291]


id: GO:0018415
namespace: biological_process
name:
  iron incorporation into iron-sulfur cluster via tris-L-cysteinyl L-cysteine persulfido bis-L-glutamato L-histidino nickel triiron disulfide trioxide

def:
  "The incorporation of iron into a 3Fe-2S cluster via tris-L-cysteinyl L-cysteine persulfido bis-L-glutamato L-histidino nickel triiron disulfide trioxide." [RESID:AA0292]


id: GO:0018416
namespace: biological_process
name:
  nickel incorporation into iron-sulfur cluster via tris-L-cysteinyl L-cysteine persulfido bis-L-glutamato L-histidino nickel triiron disulfide trioxide

def:
  "The incorporation of nickel into a 3Fe-2S complex by tris-L-cysteinyl L-cysteine persulfido bis-L-glutamato L-histidino nickel triiron disulfide trioxide." [RESID:AA0292]


id: GO:0018417
namespace: biological_process
name:
  iron incorporation into iron-sulfur cluster via tris-L-cysteinyl L-cysteine persulfido L-glutamato L-histidino L-serinyl nickel triiron disulfide trioxide

def:
  "The incorporation of iron into a 3Fe-2S cluster by tris-L-cysteinyl L-cysteine persulfido L-glutamato L-histidino L-serinyl nickel triiron disulfide trioxide." [RESID:AA0293]


id: GO:0018418
namespace: biological_process
name:
  nickel incorporation into iron-sulfur cluster via tris-L-cysteinyl L-cysteine persulfido L-glutamato L-histidino L-serinyl nickel triiron disulfide trioxide

def:
  "The incorporation of nickel into a 3Fe-2S complex by tris-L-cysteinyl L-cysteine persulfido L-glutamato L-histidino L-serinyl nickel triiron disulfide trioxide." [RESID:AA0293]


id: GO:0018419
name: protein catenane formation
namespace: biological_process
def:
  "The aggregation, arrangement and bonding together of a protein structure comprising two or more rings that are interlocked but not covalently joined; resembling the links of a chain." [ISBN:0198506732]


id: GO:0018420
name: peptide cross-linking via N6-(L-isoaspartyl)-L-lysine
namespace: biological_process
def:
  "The formation of isopeptide bonds by ligation of peptidyl-lysine and peptidyl-asparagine residues." [RESID:AA0294]


id: GO:0018421
name: UDP-N-acetylglucosamine:serine-protein N-acetylglucosamine-1-phosphotransferase activity
namespace: molecular_function
def:
  "Catalysis of the transfer of N-acetylglucosamine-1-phosphate to a serine residue in a protein." [GOC:mah, PMID:9353330]


id: GO:0018422
name: GDP-mannose:serine-protein mannose-1-phosphotransferase activity
namespace: molecular_function
def:
  "Catalysis of the transfer of mannose-1-phosphate to a serine residue in a protein." [GOC:mah, PMID:10037765]


id: GO:0018423
name: protein C-terminal leucine carboxyl O-methyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: S-adenosyl-L-methionine + protein L-leucine = S-adenosyl-L-homocysteine + protein L-leucine methyl ester. This modification occurs only at the oxygen atoms of the free alpha carboxyl group of a leucine residue at the C-terminus of the protein." [PMID:8514774]


id: GO:0018424
name: peptidyl-glutamic acid poly-ADP-ribosylation
namespace: biological_process
def:
  "This modification produces peptidyl-glutamic acid poly-ADP-ribose found in a number of nuclear proteins under certain conditions including the repair of single strand DNA breaks. The activated form of the generating enzyme poly(ADP-ribose) polymerase is itself modified in this way." [RESID:AA0295]


id: GO:0018425
name: O3-(N-acetylglucosamine-1-phosphoryl)-L-serine biosynthetic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of O3-(N-acetylglucosamine-1-phosphoryl)-L-serine. The recovery of O-phosphorylserine from acid hydrolysates suggests N-acetylglucosamine-1-phosphate residues are esterified to peptidyl serines through phosphoester bonds." [RESID:AA0296]


id: GO:0018426
name: O3-(phosphoglycosyl-D-mannose-1-phosphoryl)-L-serine biosynthetic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of O3-(phosphoglycosyl-D-mannose-1-phosphoryl)-L-serine. The polypeptide backbones of glycoproteins and mucin-like proteoglycans are extensively modified with a complex array of phosphoglycan chains that are linked to Ser/Thr-rich domains via a common Man-alpha1-PO4-Ser linkage." [RESID:AA0297]


id: GO:0018429
namespace: biological_process
name:
  copper incorporation into copper-sulfur cluster via heptakis-L-histidino tetracopper mu4-sulfide hydroxide

def:
  "The incorporation of copper into a 4Cu-S copper-sulfur cluster via heptakis-L-histidino tetracopper mu4-sulfide hydroxide." [RESID:AA0298]


id: GO:0018439
name: peptidyl-L-leucine methyl ester biosynthetic process from peptidyl-leucine
namespace: biological_process
def:
  "The modification of a C-terminal peptidyl-leucine to form peptidyl-L-leucine methyl ester." [RESID:AA0299]


id: GO:0018441
name: iron incorporation into iron-sulfur cluster via hexakis-L-cysteinyl L-serinyl octairon heptasulfide
namespace: biological_process
def:
  "The incorporation of iron into a 8Fe-7S iron-sulfur cluster via hexakis-L-cysteinyl L-serinyl octairon heptasulfide, found in nitrogenase." [PMID:9063865, RESID:AA0300]


id: GO:0018443
name: enzyme active site formation via L-aspartic 4-phosphoric anhydride
namespace: biological_process
def:
  "The transient phosphorylation of peptidyl-aspartic acid to form L-aspartic 4-phosphoric anhydride." [RESID:AA0033]


id: GO:0018444
name: translation release factor complex
namespace: cellular_component
def:
  "A heterodimeric complex involved in the release of a nascent polypeptide chain from a ribosome." [ISBN:0198547684]


id: GO:0018445
name: prothoracicotrophic hormone activity
namespace: molecular_function
def:
  "The action characteristic of prothoracicotrophic hormone, a peptide hormone that is secreted by the brain and, upon receptor binding, acts on the prothoracic gland to stimulate the release of ecdysone in insects." [GOC:mah, PMID:3301403]


id: GO:0018447
name: chloral hydrate dehydrogenase activity
namespace: molecular_function
def:
  "Catalysis of the reactions: chloral hydrate = 3 H+ + 2 e- + trichloroacetate, and chloral hydrate + H2 = H2O + trichloroethanol." [UM-BBD_enzymeID:e0229]


id: GO:0018448
name: hydroxymethylmethylsilanediol oxidase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: hydroxymethylmethylsilanediol + O2 + 2 H+ + 2 e- = formylmethylsilanediol + 2 H2O." [UM-BBD_reactionID:r0638]


id: GO:0018450
name: myrtenol dehydrogenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: myrtenol + O2 + 2 H+ + 2 e- = 2 H2O + myrtenal." [UM-BBD_reactionID:r0710]


id: GO:0018451
name: epoxide dehydrogenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: ethene oxide + NAD+ + CoA-SH = NADH + H+ + acetyl-CoA." [UM-BBD_reactionID:r0595]


id: GO:0018452
name: 5-exo-hydroxycamphor dehydrogenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 5-exo-hydroxycamphor + NAD+ = NADH + H+ + 2,5-diketocamphane." [UM-BBD_reactionID:r0427]


id: GO:0018453
name: 2-hydroxytetrahydrofuran dehydrogenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 2-hydroxytetrahydrofuran = 2 H+ + 2 e- + butyrolactone." [UM-BBD_reactionID:r0018]


id: GO:0018454
name: acetoacetyl-CoA reductase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: (R)-3-hydroxyacyl-CoA + NADP+ = 3-oxoacyl-CoA + NADPH + H+." [EC:1.1.1.36]


id: GO:0018456
name: aryl-alcohol dehydrogenase (NAD+) activity
namespace: molecular_function
def:
  "Catalysis of the reaction: an aromatic alcohol + NAD+ = an aromatic aldehyde + NADH + H+." [EC:1.1.1.90]


id: GO:0018457
name: perillyl-alcohol dehydrogenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: NAD(+) + perillyl alcohol = H(+) + NADH + perillyl aldehyde." [EC:1.1.1.144, RHEA:10667]


id: GO:0018458
name: isopiperitenol dehydrogenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: (1S,6R)-isopiperitenol + NAD(+) = (6R)-isoperitenone + H(+) + NADH." [EC:1.1.1.223, RHEA:20863]


id: GO:0018459
name: carveol dehydrogenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: (1S,5R)-carveol + NADP(+) = (R)-carvone + H(+) + NADPH." [EC:1.1.1.243, RHEA:13632]


id: GO:0018461
name: fluoren-9-ol dehydrogenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: fluoren-9-ol + 2 NADP+ = fluoren-9-one + 2 NADPH + 2 H+." [EC:1.1.1.256]


id: GO:0018462
name: 4-(hydroxymethyl)benzenesulfonate dehydrogenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 4-(hydroxymethyl)benzenesulfonate + NAD(+) = 4-formylbenzenesulfonate + H(+) + NADH." [EC:1.1.1.257, RHEA:24415]


id: GO:0018463
name: 6-hydroxyhexanoate dehydrogenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 6-hydroxyhexanoate + NAD(+) = 6-oxohexanoate + H(+) + NADH." [EC:1.1.1.258, RHEA:14228]


id: GO:0018464
name: 3-hydroxypimeloyl-CoA dehydrogenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 3-hydroxypimelyl-CoA + NAD(+) = 3-oxopimelyl-CoA + H(+) + NADH." [EC:1.1.1.259, RHEA:11171]


id: GO:0018465
name: vanillyl-alcohol oxidase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: O(2) + vanillyl alcohol = H(2)O(2) + vanillin." [EC:1.1.3.38, RHEA:10039]


id: GO:0018466
name: limonene-1,2-diol dehydrogenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: (1S,2S,4R)-limonene-1,2-diol + DCPIP+ = DCPIPH + H+ + (1S,4R)-1-hydroxy-2-oxolimonene." [UM-BBD_reactionID:r0735]


id: GO:0018467
name: formaldehyde dehydrogenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: formaldehyde + H(2)O + NAD(+) = formate + 2 H(+) + NADH." [EC:1.2.1.46, RHEA:16428]


id: GO:0018468
name: alcohol dehydrogenase (acceptor) activity
namespace: molecular_function
def:
  "Catalysis of the reaction: a primary alcohol + acceptor = an aldehyde + reduced acceptor." [EC:1.1.99.8]


id: GO:0018469
name: myrtenal dehydrogenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: myrtenal + H2O = 2 H+ + 2 e- + myrtenic acid." [UM-BBD_reactionID:r0711]


id: GO:0018470
name: 4-hydroxybutaraldehyde dehydrogenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 4-hydroxybutyraldehyde + H2O = 2 H+ + 2 e- + 4-hydroxybutanoate." [UM-BBD_reactionID:r0014]


id: GO:0018471
name: 4-chlorobenzaldehyde oxidase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 4-chlorobenzaldehyde + 2 H2O = 4-chlorobenzoate + 2 H+ + 2 e-." [UM-BBD_reactionID:r0447]


id: GO:0018472
name: 1-hydroxy-2-naphthaldehyde dehydrogenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 1-hydroxy-2-naphthaldehyde + NAD+ + H2O = NADH + H+ + 1-hydroxy-2-naphthoate." [UM-BBD_reactionID:r0485]


id: GO:0018473
name: cis-2-methyl-5-isopropylhexa-2,5-dienal dehydrogenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: cis-2-methyl-5-isopropylhexa-2,5-dienal + NAD+ + H2O = NADH + H+ + cis-2-methyl-5-isopropylhexa-2,5-dienoic acid." [UM-BBD_reactionID:r0744]


id: GO:0018474
name: 2-carboxybenzaldehyde dehydrogenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 2-carboxybenzaldehyde + NAD+ + H2O = NADH + 2 H+ + phthalate." [UM-BBD_reactionID:r0490]


id: GO:0018475
name: trans-2-methyl-5-isopropylhexa-2,5-dienal dehydrogenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: trans-2-methyl-5-isopropylhexa-2,5-dienal + NAD+ + H2O = NADH + H+ + trans-2-methyl-5-isopropylhexa-2,5-dienoic acid." [UM-BBD_reactionID:r0745]


id: GO:0018478
name: malonate-semialdehyde dehydrogenase (acetylating) activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 3-oxopropanoate + CoA + NADP+ = acetyl-CoA + CO2 + NADPH + H+." [EC:1.2.1.18]


id: GO:0018480
name: 5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 5-carboxymethyl-2-hydroxymuconate semialdehyde + H2O + NAD+ = 5-carboxymethyl-2-hydroxymuconate + NADH + H+." [EC:1.2.1.60]


id: GO:0018481
name: 4-hydroxymuconic-semialdehyde dehydrogenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: <stereo>cis,trans</stereo>-4-hydroxymuconate semialdehyde + H(2)O + NAD(+) = 2 H(+) + maleylacetate + NADH." [EC:1.2.1.61, RHEA:22423]


id: GO:0018482
name: 4-formylbenzenesulfonate dehydrogenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 4-formylbenzenesulfonate + H(2)O + NAD(+) = 4-sulfobenzoate + 2 H(+) + NADH." [EC:1.2.1.62, RHEA:18836]


id: GO:0018484
name: 4-hydroxybenzaldehyde dehydrogenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 4-hydroxybenzaldehyde + NAD+ + H2O = 4-hydroxybenzoate + NADH + H+." [EC:1.2.1.64]


id: GO:0018486
name: 2-butanone oxidase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: methyl ethyl ketone + O2 = H2O + ethyl acetate." [UM-BBD_reactionID:r0169]


id: GO:0018487
name: vanillate O-demethylase (anaerobic) activity
namespace: molecular_function
def:
  "Catalysis of the reaction: vanillate + Co+ = Co3+-CH3 + 3,4-dihydroxybenzoate." [UM-BBD_reactionID:r0758]


id: GO:0018488
name: aryl-aldehyde oxidase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: an aromatic aldehyde + O2 + H2O = an aromatic acid + hydrogen peroxide." [EC:1.2.3.9]


id: GO:0018489
name: vanillate monooxygenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: H(+) + NADH + O(2) + vanillate = 3,4-dihydroxybenzoate + formaldehyde + H(2)O + NAD(+)." [EC:1.14.13.82, RHEA:13024]


id: GO:0018490
name: 4-hydroxyphenylpyruvate oxidase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 2 (4-hydroxyphenyl)pyruvate + O(2) = 2 (4-hydroxyphenyl)acetate + 2 CO(2)." [EC:1.2.3.13, RHEA:17200]


id: GO:0018491
name: 2-oxobutyrate synthase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 2-oxobutanoate + CoA + oxidized ferredoxin = propanoyl-CoA + CO2 + reduced ferredoxin." [EC:1.2.7.2]


id: GO:0018493
name: formylmethanofuran dehydrogenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: N-formylmethanofuran + A + H(2)O + H(+) = AH(2) + CO(2) + methanofuran." [EC:1.2.99.5, RHEA:19844]


id: GO:0018495
name: 2-hydroxycyclohexane-1-carboxyl-CoA dehydrogenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 2-hydroxycyclohexane-1-carboxyl-CoA = 2 H+ + 2 e- + 2-ketocyclohexane-1-carboxyl-CoA." [UM-BBD_reactionID:r0192]


id: GO:0018496
name: 2,6-dihydroxycyclohexane-1-carboxyl-CoA dehydrogenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 2,6-dihydroxycyclohexane-1-carboxyl-CoA = 2 H+ + 2 e- + 6-oxo-2-hydroxycyclohexane-1-carboxyl-CoA." [UM-BBD_reactionID:r0205]


id: GO:0018497
name: 1-chloro-2,2-bis(4-chlorophenyl)ethane dehydrogenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 1-chloro-2,2-bis(4-chlorophenyl)ethene + 2 H+ + 2 e- = 1-chloro-2,2-bis(4-chlorophenyl)ethane. 1-chloro-2,2-bis(4-chlorophenyl)ethene is also known as DDMU; 1-chloro-2,2-bis(4-chlorophenyl)ethane is also known as DDMS." [UM-BBD_reactionID:r0514]


id: GO:0018498
name: 2,3-dihydroxy-2,3-dihydro-phenylpropionate dehydrogenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: cis-3-(3-carboxyethyl)-3,5-cyclohexadiene-1,2-diol + NAD+ = NADH + H+ + 3-(2,3-dihydroxyphenyl)propionate." [UM-BBD_enzymeID:e0308]


id: GO:0018499
name: cis-2,3-dihydrodiol DDT dehydrogenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: cis-2,3-dihydrodiol DDT + NADP+ = NADPH + 2,3-dihydroxy DDT." [UM-BBD_reactionID:r0451]


id: GO:0018500
name: trans-9R,10R-dihydrodiolphenanthrene dehydrogenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: trans-9R,10R-dihydrodiolphenanthrene + NAD+ = NADH + H+ + 9,10-dihydroxyphenanthrene." [UM-BBD_reactionID:r0575]


id: GO:0018501
name: cis-chlorobenzene dihydrodiol dehydrogenase activity
namespace: molecular_function
def:
  "Catalysis of the conversion of a di- or tetrachlorinated dienol to the corresponding catechol." [UM-BBD_enzymeID:e0411]


id: GO:0018502
name: 2,5-dichloro-2,5-cyclohexadiene-1,4-diol dehydrogenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 2,5-dichloro-2,5-cyclohexadiene-1,4-diol + NAD+ = NADH + H+ + 2,5-dichlorohydroquinone." [UM-BBD_reactionID:r0553]


id: GO:0018503
name: trans-1,2-dihydrodiolphenanthrene dehydrogenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: trans-1,2-dihydrodiolphenanthrene + NAD+ = H+ + NADH + 1,2-dihydroxyphenanthrene." [UM-BBD_reactionID:r0574]


id: GO:0018504
name: cis-1,2-dihydrobenzene-1,2-diol dehydrogenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: cis-1,2-dihydrobenzene-1,2-diol + NAD+ = catechol + NADH + H+." [EC:1.3.1.19]


id: GO:0018505
name: cis-1,2-dihydro-1,2-dihydroxynaphthalene dehydrogenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: cis-1,2-dihydronaphthalene-1,2-diol + NAD+ = naphthalene-1,2-diol + NADH + H+." [EC:1.3.1.29]


id: GO:0018507
name: cis-3,4-dihydrophenanthrene-3,4-diol dehydrogenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: (3S,4R)-3,4-dihydrophenanthrene-3,4-diol + NAD(+) = H(+) + NADH + phenanthrene-3,4-diol." [EC:1.3.1.49, RHEA:16256]


id: GO:0018508
name: cis-1,2-dihydroxycyclohexa-3,5-diene-1-carboxylate dehydrogenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: cis-1,2-dihydroxycyclohexa-3,5-diene-1-carboxylate + NAD+ = catechol + CO2 + NADH + H+." [MetaCyc:BENZOATE-CIS-DIOL-DEHYDROGENASE-RXN]


id: GO:0018509
name: cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: cis-3-phenylcyclohexa-3,5-diene-1,2-diol + NAD+ = biphenyl-2,3-diol + NADH + H+." [EC:1.3.1.56]


id: GO:0018510
name: phloroglucinol reductase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: dihydrophloroglucinol + NADP(+) = H(+) + NADPH + phloroglucinol." [EC:1.3.1.57, RHEA:10083]


id: GO:0018511
name: 2,3-dihydroxy-2,3-dihydro-p-cumate dehydrogenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: cis-2,3-dihydroxy-2,3-dihydro-p-cumate + NAD(+) = 2,3-dihydroxy-p-cumate + H(+) + NADH." [EC:1.3.1.58, RHEA:23775]


id: GO:0018512
name: obsolete 1,6-dihydroxy-5-methylcyclohexa-2,4-dienecarboxylate dehydrogenase activity
namespace: molecular_function
def:
  "OBSOLETE. Catalysis of the reaction: 1,6-dihydroxy-5-methylcyclohexa-2,4-dienecarboxylate + NAD+ = 3-methylcatechol + CO2 + NADH + H+." [EC:1.3.1.59]


id: GO:0018513
name: dibenzothiophene dihydrodiol dehydrogenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: cis-1,2-dihydroxy-1,2-dihydrodibenzothiophene + NAD(+) = 1,2-dihydroxydibenzothiophene + H(+) + NADH." [EC:1.3.1.60, RHEA:24191]


id: GO:0018515
name: pimeloyl-CoA dehydrogenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: NAD(+) + pimelyl-CoA = 2,3-didehydropimeloyl-CoA + H(+) + NADH." [EC:1.3.1.62, RHEA:19668]


id: GO:0018516
name: 2,4-dichlorobenzoyl-CoA reductase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 4-chlorobenzoyl-CoA + chloride + NADP(+) = 2,4-dichlorobenzoyl-CoA + NADPH." [EC:1.3.1.63, RHEA:23079]


id: GO:0018517
name: phthalate 4,5-cis-dihydrodiol dehydrogenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: cis-4,5-dihydroxycyclohexa-2,6-diene-1,2-dicarboxylate + NAD(+) = 4,5-dihydroxyphthalate + H(+) + NADH." [EC:1.3.1.64, RHEA:13840]


id: GO:0018518
name: 5,6-dihydroxy-3-methyl-2-oxo-1,2,5,6-tetrahydroquinoline dehydrogenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 5,6-dihydroxy-3-methyl-5,6-dihydroquinolin-2(1H)-one + NAD(+) = 5,6-dihydroxy-3-methyl-2-oxo-1,2-dihydroquinoline + H(+) + NADH." [EC:1.3.1.65, RHEA:24559]


id: GO:0018519
name: cis-dihydroethylcatechol dehydrogenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: cis-1,2-dihydro-3-ethylcatechol + NAD(+) = 3-ethylcatechol + H(+) + NADH." [EC:1.3.1.66, RHEA:18104]


id: GO:0018520
name: cis-1,2-dihydroxy-4-methylcyclohexa-3,5-diene-1-carboxylate dehydrogenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: cis-1,2-dihydroxy-4-methylcyclohexa-3,5-diene-1-carboxylate + NADP+ = 4-methylcatechol + NADPH + H+ + CO2." [EC:1.3.1.67]


id: GO:0018521
name: 1,2-dihydroxy-6-methylcyclohexa-3,5-dienecarboxylate dehydrogenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 1,6-dihydroxy-2-methylcyclohexa-2,4-dienecarboxylate + NAD(+) = 3-methylcatechol + CO(2) + NADH." [EC:1.3.1.68, RHEA:15660]


id: GO:0018522
name: benzoyl-CoA reductase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 2 ADP + cyclohexa-1,5-diene-1-carbonyl-CoA + oxidized ferredoxin + 2 phosphate = 2 ATP + 2 H(2)O + benzoyl-CoA + reduced ferredoxin." [EC:1.3.7.8]


id: GO:0018523
name: quinoline 2-oxidoreductase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: quinoline + acceptor + H2O = isoquinolin-1(2H)-one + reduced acceptor." [EC:1.3.99.17]


id: GO:0018525
name: 4-hydroxybenzoyl-CoA reductase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: benzoyl-CoA + oxidized ferredoxin + H2O = 4-hydroxybenzoyl-CoA + reduced ferredoxin." [KEGG:R05316]


id: GO:0018526
name: 2-aminobenzoyl-CoA reductase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 2-aminobenzoyl-CoA + 2 H+ + 2 e- = NH3 + benzoyl-CoA." [UM-BBD_reactionID:r0342]


id: GO:0018527
name: cyclohexylamine oxidase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: cyclohexylamine + O2 + H2O = cyclohexanone + NH3 + hydrogen peroxide." [EC:1.4.3.12]


id: GO:0018528
name: iminodiacetate dehydrogenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: iminodiacetate + OH- = H+ + 2 e- + glyoxylate + glycine." [UM-BBD_reactionID:r0589]


id: GO:0018529
name: nitrilotriacetate monooxygenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: nitrilotriacetate + NADH + H+ + O2 = NAD+ + H2O + glyoxylate + iminodiacetate." [UM-BBD_reactionID:r0587]


id: GO:0018530
name: (R)-6-hydroxynicotine oxidase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: (R)-6-hydroxynicotine + H(2)O + O(2) = 6-hydroxypseudooxynicotine + H(2)O(2)." [EC:1.5.3.6, RHEA:10015]


id: GO:0018531
name: (S)-6-hydroxynicotine oxidase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: (S)-6-hydroxynicotine + H(2)O + O(2) = 6-hydroxypseudooxynicotine + H(2)O(2)." [EC:1.5.3.5, RHEA:11883]


id: GO:0018532
name: 5,10-methenyl-5,6,7,8-tetrahydromethanopterin dehydrogenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: N5,N10-methenyltetrahydromethanopterin + H2 = N5,N10-methylenetetrahydromethanopterin." [UM-BBD_reactionID:r0353]


id: GO:0018534
name: nitrilotriacetate dehydrogenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: nitrilotriacetate + OH- = H+ + 2 e- + glyoxylate + iminodiacetate." [UM-BBD_reactionID:r0588]


id: GO:0018535
name: nicotine dehydrogenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: nicotine + acceptor + H2O = (S)-6-hydroxynicotine + reduced acceptor." [EC:1.5.99.4]


id: GO:0018537
name: coenzyme F420-dependent N5,N10-methenyltetrahydromethanopterin reductase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 5-methyltetrahydromethanopterin + coenzyme F420 + H(+) = 5,10-methylenetetrahydromethanopterin + reduced coenzyme F420." [EC:1.5.99.11, RHEA:21147]


id: GO:0018538
name: epoxide carboxylase activity
namespace: molecular_function
def:
  "Catalysis of the generic reaction: epoxide + CO2 + NAD+ + electron donor = beta-keto acid + NADH + reduced electron donor; the electron donor may be NADPH or a dithiol. This reaction is the ring opening and carboxylation of an epoxide; for example: epoxypropane + CO2 + NAD+ + NADPH = acetoacetate + NADH + NADP+." [PMID:9555888]


id: GO:0018541
name: p-benzoquinone reductase (NADPH) activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 1,4-benzoquinone + H(+) + NADPH = hydroquinone + NADP(+)." [EC:1.6.5.6, RHEA:23491]


id: GO:0018542
name: 2,3-dihydroxy DDT 1,2-dioxygenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 2,3-dihydroxy DDT + O2 = 6-oxo-2-hydroxy-7-(4-chlorophenyl)-3,8,8,8-tetrachloroocta-2E,4E-dienoate." [UM-BBD_reactionID:r0452]


id: GO:0018543
name: 4-amino-2-nitroso-6-nitrotoluene reductase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 4-amino-2-hydroxylamino-6-nitrotoluene + NADP+ = NADPH + H+ + 4-amino-2-nitroso-6-nitrotoluene." [UM-BBD_reactionID:r0464]


id: GO:0018544
name: 4-carboxy-4'-sulfoazobenzene reductase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 4-carboxy-4'-sulfoazobenzene + 4 H+ + 4 e- = 4-aminobenzoate + 4-aminobenzenesulfonate." [UM-BBD_reactionID:r0543]


id: GO:0018545
name: NAD(P)H nitroreductase activity
namespace: molecular_function
def:
  "Catalysis of the conversion of a nitrate group to an amino or hydroxylamino group on toluene or a toluene derivative." [UM-BBD_enzymeID:e0346]


id: GO:0018546
name: nitrobenzene nitroreductase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: nitrobenzene + 2 NADPH + 2 H+ = hydroxyaminobenzene + 2 NADP+ + H2O." [MetaCyc:RXN-8815]


id: GO:0018547
name: nitroglycerin reductase activity
namespace: molecular_function
def:
  "Catalysis of the removal of one or more nitrite (NO2-) groups from nitroglycerin or a derivative." [UM-BBD_enzymeID:e0038]


id: GO:0018548
name: pentaerythritol trinitrate reductase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: pentaerythritol trinitrate + NADPH = NADP+ + nitrate + pentaerythritol dinitrate." [UM-BBD_reactionID:r0025]


id: GO:0018549
name: methanethiol oxidase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: methanethiol + O2 + H2O = formaldehyde + hydrogen sulfide + hydrogen peroxide." [EC:1.8.3.4]


id: GO:0018550
name: tetrachloro-p-hydroquinone reductive dehalogenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 2,3,5,6-tetrachlorohydroquinone + 2 glutathione = 2,3,6-trichlorohydroquinone + glutathione disulfide + HCl." [UM-BBD_reactionID:r0314]


id: GO:0018551
name: hydrogensulfite reductase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: trithionate + acceptor + 2 H2O + OH- = 3 HSO3- + reduced acceptor." [EC:1.8.99.3]


id: GO:0018553
name: 3-(2,3-dihydroxyphenyl)propionate 1,2-dioxygenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 3-(2,3-dihydroxyphenyl)propionate + O2 = 2-hydroxy-6-keto-nona-2,4-dienedioate." [UM-BBD_enzymeID:e0309]


id: GO:0018554
name: 1,2-dihydroxynaphthalene dioxygenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 1,2-dihydroxynaphthalene + O2 = 2-hydroxychromene-2-carboxylate. C6 of the substrate molecular may have an NH2 group attached." [UM-BBD_enzymeID:e0255]


id: GO:0018555
name: phenanthrene dioxygenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: phenanthrene + NADH + H+ + O2 = NAD+ + cis-3,4-dihydroxy-3,4-dihydrophenanthrene." [UM-BBD_reactionID:r0455]


id: GO:0018556
name: 2,2',3-trihydroxybiphenyl dioxygenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 2,3-dihydroxybenzenoid + O2 = H+ + distal extradiol ring cleavage. Substrates are 2,2',3-trihydroxybiphenyl (forms 2-hydroxy-6-oxo-6-(2-hydroxyphenyl)-hexa-2,4-dienoate) and 2,2',3-trihydroxydiphenylether (forms 2,3-hydroxy-6-oxo-6-(2-hydroxyphenyl)-hexa-2,4-dienoate)." [UM-BBD_enzymeID:e0032]


id: GO:0018557
name: 1,2-dihydroxyfluorene 1,1-alpha-dioxygenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 1,2-dihydroxyfluorene + O2 = 2-hydroxy-4-(2-oxo-1,3-dihydro-2H-inden-1-ylidene) but-2-enoic acid." [UM-BBD_reactionID:r0422]


id: GO:0018558
name: 5,6-dihydroxy-3-methyl-2-oxo-1,2-dihydroquinoline dioxygenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 5,6-dihydroxy-3-methyl-2-oxo-1,2-dihydroquinoline + O2 = 3-methyl-5-hydroxy-6-(3-carboxy-3-oxopropenyl)-1H-2-pyridon." [UM-BBD_reactionID:r0049]


id: GO:0018559
name: 1,1-dichloro-2-(dihydroxy-4-chlorophenyl)-(4-chlorophenyl)ethene 1,2-dioxygenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 1,1-dichloro-2-(dihydroxy-4'-chorophenyl)-2-(4-chlorophenyl)ethene + O2 = 6-oxo-2-hydroxy-7-(4-chlorophenyl)-3,8,8-trichloroocta-2E,4E,7-trienoate." [UM-BBD_reactionID:r0442]


id: GO:0018561
name: 2'-aminobiphenyl-2,3-diol 1,2-dioxygenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 2'-aminobiphenyl-2,3-diol + O2 = H+ + 2-hydroxy-6-oxo-(2'-aminophenyl)-hexa-2,4-dienoate." [UM-BBD_reactionID:r0457]


id: GO:0018562
name: 3,4-dihydroxyfluorene 4,4-alpha-dioxygenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 3,4-dihydroxyfluorene + O2 = 2-hydroxy-4-(1-oxo-1,3-dihydro-2H-inden-2-ylidene) but-2-enoic acid." [UM-BBD_reactionID:r0415]


id: GO:0018563
name: 2,3-dihydroxy-ethylbenzene 1,2-dioxygenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 2,3-dihydroxyethylbenzene + O2 = H+ + 2-hydroxy-6-oxoocta-2,4-dienoate." [UM-BBD_reactionID:r0310]


id: GO:0018564
name: carbazole 1,9a-dioxygenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: carbazole + NADH + O2 + H+ = NAD+ + 2'-aminobiphenyl-2,3-diol." [UM-BBD_reactionID:r0456]


id: GO:0018565
name: dihydroxydibenzothiophene dioxygenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 1,2-dihydroxydibenzothiophene + O2 = cis-4-(2-(3-hydroxy)-thionaphthenyl)-2-oxo-3-butenoate." [UM-BBD_reactionID:r0162]


id: GO:0018566
name: 1,2-dihydroxynaphthalene-6-sulfonate 1,8a-dioxygenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 1,2-dihydroxynaphthalene-6-sulfonate + O2 = H+ + (Z)-4-(2-hydroxy-5-sulfonatophenyl)-2-oxo-3-butenoate." [UM-BBD_reactionID:r0324]


id: GO:0018567
name: styrene dioxygenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: styrene + O2 + NADH + H+ = NAD+ + styrene cis-glycol." [UM-BBD_reactionID:r0256]


id: GO:0018568
name: 3,4-dihydroxyphenanthrene dioxygenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 3,4-dihydroxyphenanthrene + O2 = H+ + 2-hydroxy-2 H-benzo[h]chromene-2-carboxylate." [UM-BBD_reactionID:r0501]


id: GO:0018569
name: hydroquinone 1,2-dioxygenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: hydroquinone + O2 = cis,trans-4-hydroxymuconic semialdehyde." [UM-BBD_reactionID:r0228]


id: GO:0018570
name: p-cumate 2,3-dioxygenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: p-cumate + NADH + H+ + O2 = NAD+ + cis-2,3-dihydroxy-2,3-dihydro-p-cumate." [UM-BBD_reactionID:r0395]


id: GO:0018571
name: 2,3-dihydroxy-p-cumate dioxygenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 2,3-dihydroxy-p-cumate + O2 = 2-hydroxy-3-carboxy-6-oxo-7-methylocta-2,4-dienoate." [MetaCyc:RXN-666, UM-BBD_reactionID:r0397]


id: GO:0018572
name: 3,5-dichlorocatechol 1,2-dioxygenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 3,5-dichlorocatechol + O2 = 2 H+ + 2,4-dichloro-cis,cis-muconate." [UM-BBD_reactionID:r0276]


id: GO:0018573
name: 2-aminophenol 1,6-dioxygenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 2-aminophenol + O2 = 2-aminomuconic semialdehyde." [UM-BBD_reactionID:r0305]


id: GO:0018574
name: 2,6-dichloro-p-hydroquinone 1,2-dioxygenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 2,6-dichlorohydroquinone + O2 + H2O = HCl + 2 H+ + 2-chloromaleylacetate." [UM-BBD_enzymeID:e0422]


id: GO:0018575
name: chlorocatechol 1,2-dioxygenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 3,6-dichlorocatechol + O2 = 2 H+ + 2,5-dichloro-cis,cis-muconate." [UM-BBD_reactionID:r0655]


id: GO:0018578
name: protocatechuate 3,4-dioxygenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 3,4-dihydroxybenzoate + O2 = 3-carboxy-cis,cis-muconate." [EC:1.13.11.3]


id: GO:0018579
name: protocatechuate 4,5-dioxygenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: protocatechuate + O2 = 4-carboxy-2-hydroxymuconate semialdehyde." [EC:1.13.11.8]


id: GO:0018580
name: nitronate monooxygenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: ethylnitronate + O(2) = acetaldehyde + nitrite." [EC:1.13.12.16, RHEA:28770]


id: GO:0018582
name: 1-hydroxy-2-naphthoate 1,2-dioxygenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 1-hydroxy-2-naphthoate + O2 = (3E)-4-(2-carboxyphenyl)-2-oxobut-3-enoate." [EC:1.13.11.38]


id: GO:0018583
name: biphenyl-2,3-diol 1,2-dioxygenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: biphenyl-2,3-diol + O2 = 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate + H2O." [EC:1.13.11.39]


id: GO:0018584
name: 2,4,5-trichlorophenoxyacetic acid oxygenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 2,4,5-trichlorophenoxyacetic acid + 1/2 O2 = glyoxylate + 2,4,5-trichlorophenol." [UM-BBD_reactionID:r0359]


id: GO:0018585
name: fluorene oxygenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: fluorene + 2 H+ + 2 e- + O2 = H2O + 9-fluorenol." [UM-BBD_reactionID:r0407]


id: GO:0018586
name: mono-butyltin dioxygenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: butyltin + O2 + 2 H+ + 2 e- = H2O + beta-hydroxybutyltin." [UM-BBD_reactionID:r0647]


id: GO:0018588
name: tri-n-butyltin dioxygenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: tri-n-butyltin + O2 + 2 H+ + 2 e- = H2O + beta-hydroxybutyldibutyltin." [UM-BBD_reactionID:r0643]


id: GO:0018589
name: di-n-butyltin dioxygenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: dibutyltin + O2 + 2 H+ + 2 e- = H2O + beta-hydroxybutylbutyltin." [UM-BBD_reactionID:r0645]


id: GO:0018590
name: methylsilanetriol hydroxylase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: methylsilanetriol + O2 + 2 H+ + 2 e- = H2O + hydroxymethylsilanetriol." [UM-BBD_reactionID:r0640]


id: GO:0018591
name: methyl tertiary butyl ether 3-monooxygenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: methyl tert-butyl ether + 1/2 O2 = tert-butyl alcohol + formaldehyde." [UM-BBD_reactionID:r1023]


id: GO:0018592
name: 4-nitrocatechol 4-monooxygenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 4-nitrocatechol + O2 + 4 e- + 3 H+ = H2O + nitrite + 1,2,4-benzenetriol." [UM-BBD_reactionID:r0231]


id: GO:0018593
name: 4-chlorophenoxyacetate monooxygenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 4-chlorophenoxyacetate + 1/2 O2 = glyoxylate + 4-chlorophenol." [UM-BBD_reactionID:r0281]


id: GO:0018594
name: tert-butanol 2-monooxygenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: tert-butanol + 1/2 O2 = 2-methyl-2-hydroxy-1-propanol." [UM-BBD_reactionID:r0615]


id: GO:0018595
name: alpha-pinene monooxygenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: alpha-pinene + O2 + 2 H+ + 2 e- = H2O + pinocarveol." [UM-BBD_reactionID:r0716]


id: GO:0018596
name: dimethylsilanediol hydroxylase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: dimethylsilanediol + O2 + 2 H+ + 2 e- = H2O + hydroxymethylmethylsilanediol." [UM-BBD_reactionID:r0637]


id: GO:0018597
name: ammonia monooxygenase activity
namespace: molecular_function
def:
  "Catalysis of the oxidation of alkanes (up to C8) to alcohols and alkenes (up to C5) to epoxides and alcohols in the presence of ammonium ions." [PMID:16347810]


id: GO:0018598
name: hydroxymethylsilanetriol oxidase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: hydroxymethylsilanetriol + O2 + 2 H+ + 2 e- = 2 H2O + formylsilanetriol." [UM-BBD_reactionID:r0641]


id: GO:0018599
name: 2-hydroxyisobutyrate 3-monooxygenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 2-hydroxyisobutyrate + 1/2 O2 = 2,3-dihydroxy-2-methyl propionate." [UM-BBD_reactionID:r0619]


id: GO:0018600
name: alpha-pinene dehydrogenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: alpha-pinene + O2 + 2 H+ + 2 e- = H2O + myrtenol." [UM-BBD_reactionID:r0709]


id: GO:0018601
name: 4-nitrophenol 2-monooxygenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 4-nitrophenol + H(+) + NADH + O(2) = 4-nitrocatechol + H(2)O + NAD(+)." [EC:1.14.13.29, RHEA:12571]


id: GO:0018602
name: 2,4-dichlorophenoxyacetate alpha-ketoglutarate dioxygenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 2,4-dichlorophenoxyacetate + 2-oxoglutarate + oxygen = 2,4-dichlorophenol + glyoxylate + succinate + CO2." [UM-BBD_reactionID:r0274]


id: GO:0018603
name: nitrobenzene 1,2-dioxygenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: nitrobenzene + NADH + O2 = NAD+ + nitrite + catechol." [UM-BBD_reactionID:r0306]


id: GO:0018604
name: 4-aminobenzoate 3,4-dioxygenase (deaminating) activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 4-aminobenzoate + 2 H+ + O2 + 2 e- = NH3 + 3,4-dihydroxybenzoate." [UM-BBD_reactionID:r0566]


id: GO:0018606
name: benzenesulfonate dioxygenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: toluene-4-sulfonate + NADH + O2 + H+ = NAD+ + HSO3(-) + 4-methylcatechol." [UM-BBD_reactionID:r0295]


id: GO:0018607
name: 1-indanone monooxygenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 1-indanone + NADPH + 1/2 O2 = NADP+ + 3,4-dihydrocoumarin." [UM-BBD_reactionID:r0417]


id: GO:0018608
name: 1-indanone dioxygenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 1-indanone + NADPH + 1/2 O2 = NADP+ + 3-hydroxy-1-indanone." [UM-BBD_reactionID:r0416]


id: GO:0018609
name: chlorobenzene dioxygenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 2,3-unsubstituted benzenoid + O2 + NAD(P)H + H+ = 2,3-cis-dihydroxydihydrobenzenoid + NAD(P)+. Substrates include 1,4-dichlorobenzene (forms 3,6-dichloro-cis-1,2-dihydroxycyclohexa-3,5-diene), 1,2,3,4-tetrachlorobenzene (forms cis-chlorobenzene dihydrodiol) and 1,2,4-trichlorobenzene (forms 3,4,6-trichloro-cis-1,2-dihydroxycyclohexa-3,5-diene)." [UM-BBD_enzymeID:e0062]


id: GO:0018610
name: dibenzofuran 4,4a-dioxygenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: dibenzofuran + NADH + H+ + O2 = 2,2',3-trihydroxybiphenyl + NAD+." [MetaCyc:R606-RXN]


id: GO:0018611
name: toluate dioxygenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: methylbenzoate + NADH + O2 + H+ = NAD+ + 1,2-dihydroxymethylcyclohexa-3,5-dienecarboxylate." [UM-BBD_enzymeID:e0190]


id: GO:0018612
name: dibenzothiophene dioxygenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: dibenzothiophene + NADH + O2 + H+ = NAD+ + cis-1,2-dihydroxy-1,2-dihydrodibenzothiophene." [UM-BBD_reactionID:r0160]


id: GO:0018613
name: 9-fluorenone dioxygenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 9-fluorenone + 2 NADPH + O2 = 2 NADP+ + 3,4-dihydroxy-3,4-dihydro-9-fluorenone." [UM-BBD_reactionID:r0409]


id: GO:0018614
name: ethylbenzene dioxygenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: ethylbenzene + O2 + NADH + H+ = NAD+ + cis-2,3-dihydroxy-2,3-dihydroethylbenzene." [UM-BBD_reactionID:r0247]


id: GO:0018615
name: 2-indanone monooxygenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 2-indanone + NADPH + 1/2 O2 = NADP+ + 3-isochromanone." [UM-BBD_reactionID:r0424]


id: GO:0018616
name: trihydroxytoluene dioxygenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 2,3,5-trihydroxytoluene + O2 = 2,4,6-trioxoheptanoate." [MetaCyc:R305-RXN, UM-BBD_reactionID:r0093]


id: GO:0018617
name: 4-aminobenzenesulfonate 3,4-dioxygenase (deaminating) activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 4-aminobenzenesulfonate + 2 H+ + O2 + 2 e- = NH3 + 4-sulfocatechol." [UM-BBD_reactionID:r0580]


id: GO:0018618
name: anthranilate 1,2-dioxygenase (deaminating, decarboxylating) activity
namespace: molecular_function
def:
  "Catalysis of the reaction: anthranilate + NADPH + H+ + O2 = catechol + CO2 + NADP+ + NH3." [EC:1.14.12.1]


id: GO:0018619
name: benzene 1,2-dioxygenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: benzene + H(+) + NADH + O(2) = cis-cyclohexa-3,5-diene-1,2-diol + NAD(+)." [EC:1.14.12.3, RHEA:13816]


id: GO:0018620
name: phthalate 4,5-dioxygenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: H(+) + NADH + O(2) + phthalate = cis-4,5-dihydroxycyclohexa-2,6-diene-1,2-dicarboxylate + NAD(+)." [EC:1.14.12.7, RHEA:17492]


id: GO:0018621
name: 4-sulfobenzoate 3,4-dioxygenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 4-sulfobenzoate + H(+) + NADH + O(2) = 3,4-dihydroxybenzoate + NAD(+) + sulfite." [EC:1.14.12.8, RHEA:13940]


id: GO:0018622
name: 4-chlorophenylacetate 3,4-dioxygenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 4-chlorophenylacetate + NADH + O(2) = 3,4-dihydroxyphenylacetate + chloride + NAD(+)." [EC:1.14.12.9, RHEA:14692]


id: GO:0018624
name: toluene dioxygenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: H(+) + NADH + O(2) + toluene = (1S,2R)-3-methylcyclohexa-3,5-diene-1,2-diol + NAD(+)." [EC:1.14.12.11, RHEA:16740]


id: GO:0018625
name: naphthalene 1,2-dioxygenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: naphthalene + NADH + H+ + O2 = (1R,2S)-1,2-dihydronaphthalene-1,2-diol + NAD+." [EC:1.14.12.12]


id: GO:0018626
name: 2-chlorobenzoate 1,2-dioxygenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 2-chlorobenzoate + NADH + H+ + O2 = catechol + chloride + NAD+ + CO2." [EC:1.14.12.13]


id: GO:0018627
name: 2-aminobenzenesulfonate 2,3-dioxygenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 2-aminobenzenesulfonate + 2 H(+) + NADH + O(2) = 2,3-dihydroxybenzenesulfonate + NAD(+) + NH(4)(+). 2,3-dihydroxybenzenesulfonate is also known as 3-sulfocatechol." [EC:1.14.12.14, RHEA:23471]


id: GO:0018628
name: terephthalate 1,2-dioxygenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: H(+) + NADH + O(2) + terephthalate = (3S,4R)-3,4-dihydroxycyclohexa-1,5-diene-1,4-dicarboxylate + NAD(+)." [EC:1.14.12.15, RHEA:10315]


id: GO:0018629
name: 2-hydroxyquinoline 5,6-dioxygenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: quinolin-2-ol + NADH + H+ + O2 = 2,5,6-trihydroxy-5,6-dihydroquinoline + NAD+." [EC:1.14.12.16]


id: GO:0018630
name: 3,5-xylenol methylhydroxylase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 3-hydroxytoluene + NADH + O2 = NAD+ + OH- + 3-hydroxybenzyl alcohol." [UM-BBD_reactionID:r0081]


id: GO:0018631
name: phenylacetate hydroxylase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: phenylacetate + NADH + O2 = NAD+ + OH- + 2-hydroxyphenylacetate." [UM-BBD_reactionID:r0036]


id: GO:0018632
name: 4-nitrophenol 4-monooxygenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: p-nitrophenol + O2 + NADPH = H2O + NADP+ + nitrite + p-benzoquinone." [UM-BBD_reactionID:r0226]


id: GO:0018633
name: dimethyl sulfide monooxygenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: dimethyl sulfide + NADH + O2 = NAD+ + OH- + methanethiol + formaldehyde." [UM-BBD_reactionID:r0208]


id: GO:0018634
name: alpha-pinene monooxygenase [NADH] activity
namespace: molecular_function
def:
  "Catalysis of the reaction: alpha-pinene + NADH + H+ + O2 = NAD+ + H2O + alpha-pinene oxide." [UM-BBD_reactionID:r0742]


id: GO:0018635
name: (R)-limonene 1,2-monooxygenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: (4R)-limonene + NAD(P)H + H+ + O2 = NAD(P)+ + H2O + (4R)-limonene-1,2-epoxide." [UM-BBD_enzymeID:e0462]


id: GO:0018636
name: phenanthrene 9,10-monooxygenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: phenanthrene + O2 + NADH + H+ = H2O + NAD+ + phenanthrene-9,10-oxide." [UM-BBD_reactionID:r0495]


id: GO:0018637
name: 1-hydroxy-2-naphthoate hydroxylase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 1-hydroxy-2-naphthoate + O2 + NADPH + 2 H+ = NADP+ + H2O + CO2 + 1,2-dihydroxynaphthalene." [UM-BBD_reactionID:r0491]


id: GO:0018639
name: xylene monooxygenase activity
namespace: molecular_function
def:
  "Catalysis of the reactions: toluene + 1/2 O2 = benzyl alcohol, and xylene + 1/2 O2 = methylbenzyl alcohol." [UM-BBD_enzymeID:e0172]


id: GO:0018640
name: dibenzothiophene monooxygenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: dibenzothiophene + NADH + H+ + O2 = dibenzothiophene-5-oxide + NAD+ + H2O." [MetaCyc:RXN-621]


id: GO:0018641
name: 6-hydroxy-3-methyl-2-oxo-1,2-dihydroquinoline 6-monooxygenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 6-hydroxy-3-methyl-2-oxo-1,2-dihydroquinoline + O2 + 2 H+ + 2 e- = H2O + 5,6-dihydroxy-3-methyl-2-oxo-1,2-dihydroquinoline." [UM-BBD_reactionID:r0048]


id: GO:0018642
name: chlorophenol 4-monooxygenase activity
namespace: molecular_function
def:
  "Catalysis of the addition or substitution of an OH group on C4 of a halogenated phenol." [UM-BBD_enzymeID:e0252]


id: GO:0018643
name: carbon disulfide oxygenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: carbon disulfide + NADH + H+ + O2 = [S] + H2O + NAD+ + carbonyl sulfide." [UM-BBD_reactionID:r0599]


id: GO:0018645
name: alkene monooxygenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: propene + NADH + H+ + O2 = 1,2-epoxypropane + NAD+ + H2O." [EC:1.14.13.69]


id: GO:0018646
name: 1-hydroxy-2-oxolimonene 1,2-monooxygenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: (1S,4R)-1-hydroxy-2-oxolimonene + NADPH + O2 = NADP+ + OH- + (3R)-3-isopropenyl-6-oxoheptanoate." [UM-BBD_reactionID:r0736]


id: GO:0018647
name: phenanthrene 1,2-monooxygenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: phenanthrene + O2 + NADH + H+ = H2O + NAD+ + phenanthrene-1,2-oxide." [UM-BBD_enzymeID:e0333]


id: GO:0018648
name: methanesulfonate monooxygenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: methanesulfonate + NADH + H+ + O2 = formaldehyde + NAD+ + sulfite + H2O." [EC:1.14.13.111]


id: GO:0018649
name: tetrahydrofuran hydroxylase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: tetrahydrofuran + O2 + 2 H+ + 2 e- = H2O + 2-hydroxytetrahydrofuran." [UM-BBD_reactionID:r0017]


id: GO:0018650
name: styrene monooxygenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: styrene + NADPH + FADH + O2 = NADP+ + FAD+ + H2O + styrene oxide." [UM-BBD_reactionID:r0225]


id: GO:0018651
name: toluene-4-sulfonate monooxygenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: toluene-4-sulfonate + 1/2 O2 + H+ = HSO3(-) + 4-hydroxytoluene." [UM-BBD_reactionID:r0296]


id: GO:0018652
name: toluene-sulfonate methyl-monooxygenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: toluene-4-sulfonate + NADH + O2 = NAD+ + OH- + 4-sulfobenzyl alcohol." [UM-BBD_reactionID:r0290]


id: GO:0018653
name: 3-methyl-2-oxo-1,2-dihydroquinoline 6-monooxygenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 3-methyl-2-oxo-1,2-dihydroquinoline + O2 + 2 H+ + 2 e- = H2O + 6-hydroxy-3-methyl-2-oxo-1,2-dihydroquinoline." [EC:1.14.13.-]


id: GO:0018654
name: 2-hydroxy-phenylacetate hydroxylase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 2-hydroxyphenylacetate + NADH + O2 = NAD+ + OH- + homogentisate." [UM-BBD_reactionID:r0252]


id: GO:0018655
name: 2-oxo-delta3-4,5,5-trimethylcyclopentenylacetyl-CoA 1,2-monooxygenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 2-oxo-delta3-4,5,5-trimethylcyclopentenylacetyl-CoA + NADH + H+ + O2 = NAD+ + H2O + delta2,5-3,4,4-trimethylpimelyl-CoA." [UM-BBD_reactionID:r0430]


id: GO:0018656
name: phenanthrene 3,4-monooxygenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: phenanthrene + O2 + NADH + H+ = H2O + NAD+ + phenanthrene-3,4-oxide." [UM-BBD_reactionID:r0508]


id: GO:0018658
name: salicylate 1-monooxygenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: salicylate + NADH + H+ + O2 = catechol + NAD+ + H2O + CO2." [EC:1.14.13.1]


id: GO:0018659
name: 4-hydroxybenzoate 3-monooxygenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 4-hydroxybenzoate + NADPH + H+ + O2 = protocatechuate + NADP+ + H2O." [EC:1.14.13.2]


id: GO:0018660
name: 4-hydroxyphenylacetate,NADH:oxygen oxidoreductase (3-hydroxylating) activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 4-hydroxyphenylacetate + NADH + H+ + O2 = 3,4-dihydroxyphenylacetate + NAD+ + H2O." [KEGG:R02698]


id: GO:0018661
name: orcinol 2-monooxygenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: H(+) + NADH + O(2) + orcinol = 2,3,5-trihydroxytoluene + H(2)O + NAD(+)." [EC:1.14.13.6, RHEA:19604]


id: GO:0018663
name: 2,6-dihydroxypyridine 3-monooxygenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 2,6-dihydroxypyridine + H(+) + NADH + O(2) = 2,3,6-trihydroxypyridine + H(2)O + NAD(+)." [EC:1.14.13.10, RHEA:16920]


id: GO:0018664
name: benzoate 4-monooxygenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: benzoate + H(+) + NADPH + O(2) = 4-hydroxybenzoate + H(2)O + NADP(+)." [EC:1.14.13.12, RHEA:18036]


id: GO:0018665
name: 4-hydroxyphenylacetate 1-monooxygenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 4-hydroxyphenylacetate + NADPH + H+ + O2 = homogentisate + NADP+ + H2O." [EC:1.14.13.18]


id: GO:0018666
name: 2,4-dichlorophenol 6-monooxygenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 2,4-dichlorophenol + NADPH + H+ + O2 = 3,5-dichlorocatechol + NADP+ + H2O." [EC:1.14.13.20]


id: GO:0018667
name: cyclohexanone monooxygenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: cyclohexanone + NADPH + H+ + O2 = 6-hexanolide + NADP+ + H2O." [EC:1.14.13.22]


id: GO:0018668
name: 3-hydroxybenzoate 4-monooxygenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 3-hydroxybenzoate + H(+) + NADPH + O(2) = 3,4-dihydroxybenzoate + H(2)O + NADP(+)." [EC:1.14.13.23, RHEA:11483]


id: GO:0018669
name: 3-hydroxybenzoate 6-monooxygenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 3-hydroxybenzoate + H(+) + NADH + O(2) = 2,5-dihydroxybenzoate + H(2)O + NAD(+)." [EC:1.14.13.24, RHEA:22695]


id: GO:0018670
name: 4-aminobenzoate 1-monooxygenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 4-aminobenzoate + NADPH + H+ + O2 = 4-hydroxyaniline + NADP+ + H2O + CO2." [EC:1.14.13.27]


id: GO:0018671
name: 4-hydroxybenzoate 3-monooxygenase [NAD(P)H] activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 4-hydroxybenzoate + NAD(P)H + H+ + O2 = 3,4-dihydroxybenzoate + NAD(P)+ + H2O." [EC:1.14.13.33]


id: GO:0018672
name: anthranilate 3-monooxygenase (deaminating) activity
namespace: molecular_function
def:
  "Catalysis of the reaction: anthranilate + 2 H(+) + NADPH + O(2) = 2,3-dihydroxybenzoate + NADP(+) + NH(4)(+)." [EC:1.14.13.35, RHEA:21239]


id: GO:0018673
name: anthraniloyl-CoA monooxygenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 2-aminobenzoyl-CoA + 2 NADPH + 2 H+ + O2 = 2-amino-5-oxocyclohex-1-enecarboxyl-CoA + H2O + 2 NADP+." [EC:1.14.13.40]


id: GO:0018674
name: (S)-limonene 3-monooxygenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: (4S)-limonene + H(+) + NADPH + O(2) = (1S,6R)-isopiperitenol + H(2)O + NADP(+)." [EC:1.14.13.47, RHEA:15132]


id: GO:0018675
name: (S)-limonene 6-monooxygenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: (-)-limonene + NADPH + H+ + O2 = (-)-trans-carveol + NADP+ + H2O." [EC:1.14.13.48]


id: GO:0018676
name: (S)-limonene 7-monooxygenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: (4S)-limonene + H(+) + NADPH + O(2) = (4S)-perillyl alcohol + H(2)O + NADP(+)." [EC:1.14.13.49, RHEA:23435]


id: GO:0018677
name: pentachlorophenol monooxygenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: pentachlorophenol + NADPH + H+ + O2 = tetrachlorohydroquinone + NADP+ + chloride." [EC:1.14.13.50]


id: GO:0018678
name: 4-hydroxybenzoate 1-hydroxylase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 4-hydroxybenzoate + NADPH + H+ + O2 = hydroquinone + NADP+ + H2O + CO2." [EC:1.14.13.64]


id: GO:0018679
name: dibenzothiophene-5,5-dioxide monooxygenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: dibenzothiophene-5,5-dioxide + O2 + 2 NADH + H+ = 2 NAD+ + H2O + 2'-hydroxybiphenyl-2-sulfinate." [UM-BBD_reactionID:r0235]


id: GO:0018680
name: deethylatrazine monooxygenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 2 deethylatrazine + O2 = 2 CH3COCH3 + 2 deisopropyldeethylatrazine." [UM-BBD_reactionID:r0128]


id: GO:0018681
name: deisopropylatrazine monooxygenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 2 deisopropylatrazine + O2 = 2 acetaldehyde + 2 deisopropyldeethylatrazine." [KEGG:R05567]


id: GO:0018682
name: atrazine N-dealkylase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: atrazine + O2 + 2 H+ = deethylatrazine + acetaldehyde + H2O." [MetaCyc:R461-RXN, UM-BBD_reactionID:r0127]


id: GO:0018683
name: camphor 5-monooxygenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: (+)-camphor + putidaredoxin + O2 = (+)-exo-5-hydroxycamphor + oxidized putidaredoxin + H2O." [EC:1.14.15.1]


id: GO:0018684
name: camphor 1,2-monooxygenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: (1R)-bornane-2,5-dione + reduced rubredoxin + O2 = 5-oxo-1,2-campholide + oxidized rubredoxin + H2O." [EC:1.14.15.2]


id: GO:0018685
name: alkane 1-monooxygenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: octane + reduced rubredoxin + O2 = 1-octanol + oxidized rubredoxin + H2O." [EC:1.14.15.3]


id: GO:0018686
name: 6-hydroxy pseudo-oxynicotine monooxygenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 2 6-hydroxypseudooxynicotine + O2 = 2 2,6-dihydroxypseudooxynicotine." [UM-BBD_reactionID:r0480]


id: GO:0018687
name: biphenyl 2,3-dioxygenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: biphenyl + NADH + H+ + O2 = (2R,3S)-3-phenylcyclohexa-3,5-diene-1,2-diol + NAD+. This reaction requires Fe2+." [EC:1.14.12.18]


id: GO:0018688
name: DDT 2,3-dioxygenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 1,1,1-trichloro-2,2-bis-(4-chlorophenyl)ethane + O2 + 2 H+ + 2 e- = cis-2,3-dihydrodiol DDT. 1,1,1-trichloro-2,2-bis-(4-chlorophenyl)ethane is also known as DDT." [UM-BBD_reactionID:r0450]


id: GO:0018689
name: naphthalene disulfonate 1,2-dioxygenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: (1/2)-unsubstituted naphthalenoid-(2/1)-sulfonate + 2 H+ + 2 e- + O2 = 1,2-dihydroxynaphthalene derivative + HSO3(-). Substrates include naphthalene-1,6-disulfonate (forms 1,2-dihydroxynaphthalene-6-sulfonate), naphthalene-1-sulfonate (forms 1,2-dihydroxynaphthalene), naphthalene-2,6-disulfonate (forms 1,2-dihydroxynaphthalene-6-sulfonate) and naphthalene-2-sulfonate (forms 1,2-dihydroxynaphthalene)." [UM-BBD_enzymeID:e0249]


id: GO:0018690
name: 4-methoxybenzoate monooxygenase (O-demethylating) activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 4-methoxybenzoate + AH(2) + O(2) = 4-hydroxybenzoate + A + formaldehyde + H(2)O." [EC:1.14.99.15, RHEA:18616]


id: GO:0018693
name: ethylbenzene hydroxylase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: A + ethylbenzene + H(2)O = (S)-1-phenylethanol + AH(2)." [EC:1.17.99.2, RHEA:17900]


id: GO:0018694
name: p-cymene methyl hydroxylase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: p-cymene + NADH + O2 = NAD+ + OH- + p-cumic alcohol." [UM-BBD_reactionID:r0392]


id: GO:0018695
name: 4-cresol dehydrogenase (hydroxylating) activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 4-cresol + acceptor + H2O = 4-hydroxybenzaldehyde + reduced acceptor." [EC:1.17.99.1]


id: GO:0018697
name: carbonyl sulfide nitrogenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: carbonyl sulfide + 2 H+ + 2 e- = hydrogen sulfide + carbon monoxide." [UM-BBD_reactionID:r0600]


id: GO:0018699
name: 1,1,1-trichloroethane reductive dehalogenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 1,1,1-trichloroethane + 2 H+ + 2 e- = 1,1-dichloroethane + HCl." [UM-BBD_reactionID:r1007]


id: GO:0018700
name: 2-chloro-N-isopropylacetanilide reductive dehalogenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 2-chloro-N-isopropylacetanilide + H+ + 2 e- = Cl- + N-isopropylacetanilide." [UM-BBD_reactionID:r0719]


id: GO:0018701
name: 2,5-dichlorohydroquinone reductive dehalogenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: organohalide + 2 H+ + 2 e- = R-H + HCl. Reactants include chlorohydroquinone (forms hydroquinone) and 2,5-dichlorohydroquinone (forms chlorohydroquinone)." [UM-BBD_enzymeID:e0366]


id: GO:0018702
name: 1,1-dichloro-2,2-bis(4-chlorophenyl)ethene dehalogenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 1,1-dichloro-2,2-bis(4-chlorophenyl)ethene + H+ + 2 e- = Cl- + 1-chloro-2,2-bis(4-chlorophenyl)ethene. 1,1-dichloro-2,2-bis(4-chlorophenyl)ethene is also known as DDE; 1-chloro-2,2-bis(4-chlorophenyl)ethene is also known as DDMU." [UM-BBD_reactionID:r0440]


id: GO:0018703
name: 2,4-dichlorophenoxyacetate dehalogenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 2,4-dichlorophenoxyacetic acid + H+ + 2 e- = Cl- + 4-chlorophenoxyacetate." [UM-BBD_reactionID:r0280]


id: GO:0018704
name: obsolete 5-chloro-2-hydroxymuconic semialdehyde dehalogenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 5-chloro-2-hydroxymuconic semialdehyde + H+ + 2 e- = Cl- + 2-hydroxymuconic semialdehyde." [UM-BBD_enzymeID:e0237]


id: GO:0018705
name: 1,2-dichloroethene reductive dehalogenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 1,2-dichloroethene + 2 H+ + 2 e- = HCl + vinyl chloride." [UM-BBD_enzymeID:e0272]


id: GO:0018706
name: pyrogallol hydroxytransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 1,2,3,5-tetrahydroxybenzene + 1,2,3-trihydroxybenzene = 1,3,5-trihydroxybenzene + 1,2,3,5-tetrahydroxybenzene." [EC:1.97.1.2]


id: GO:0018707
name: 1-phenanthrol methyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 1-phenanthrol + X-CH3 = X + 1-methoxyphenanthrene." [UM-BBD_reactionID:r0493]


id: GO:0018708
name: thiol S-methyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: S-adenosyl-L-methionine + a thiol = S-adenosyl-L-homocysteine + a thioether." [EC:2.1.1.9]


id: GO:0018710
name: acetone carboxylase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: acetone + ATP + CO(2) + 2 H(2)O = acetoacetate + AMP + 4 H(+) + 2 phosphate." [EC:6.4.1.6, RHEA:18388]


id: GO:0018711
name: benzoyl acetate-CoA thiolase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: benzoyl acetyl-CoA + CoA = acetyl-CoA + benzoyl-CoA." [UM-BBD_reactionID:r0243]


id: GO:0018712
name: 3-hydroxybutyryl-CoA thiolase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 3-hydroxy-5-oxohexanoyl-CoA + CoASH = 3-hydroxybutyryl-CoA + acetyl-CoA." [UM-BBD_reactionID:r0010]


id: GO:0018713
name: 3-ketopimelyl-CoA thiolase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 3-ketopimeloyl-CoA + CoA = glutaryl-CoA + acetyl-CoA." [UM-BBD_reactionID:r0197]


id: GO:0018715
name: 9-phenanthrol UDP-glucuronosyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 9-phenanthrol + UDP-glucuronate = 9-phenanthryl-beta-D-glucuronide + UDP." [UM-BBD_reactionID:r0567]


id: GO:0018716
name: 1-phenanthrol glycosyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 1-phenanthrol + glucose = 1-phenanthryl-beta-D-glucopyranoside + H2O." [UM-BBD_reactionID:r0525]


id: GO:0018717
name: 9-phenanthrol glycosyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 9-phenanthrol + glucose = 9-phenanthryl-beta-D-glucopyranoside + H2O." [UM-BBD_reactionID:r0511]


id: GO:0018718
name: 1,2-dihydroxy-phenanthrene glycosyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 1,2-dihydroxyphenanthrene + UDP-glucose = 2-hydroxy-1-phenanthryl-beta-D-glucopyranoside + UDP." [UM-BBD_reactionID:r0569]


id: GO:0018719
name: 6-aminohexanoate transaminase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 6-aminohexanoate + alpha-ketoglutarate = glutamate + 6-oxohexanoate." [UM-BBD_reactionID:r0449]


id: GO:0018721
name: trans-9R,10R-dihydrodiolphenanthrene sulfotransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: trans-9R,10R-dihydrodiolphenanthrene + 2 X-SO3(-) = 2 HX + phenanthrene-9,10-dihydrodiolsulfate conjugate." [UM-BBD_reactionID:r0559]


id: GO:0018722
name: 1-phenanthrol sulfotransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 1-phenanthrol + X-SO3(-) = HX + 1-phenanthrylsulfate." [UM-BBD_reactionID:r0565]


id: GO:0018723
name: 3-phenanthrol sulfotransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 3-phenanthrol + X-SO3(-) = HX + 3-phenanthrylsulfate." [UM-BBD_reactionID:r0561]


id: GO:0018724
name: 4-phenanthrol sulfotransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 4-phenanthrol + X-SO3(-) = HX + 4-phenanthrylsulfate." [UM-BBD_reactionID:r0562]


id: GO:0018725
name: trans-3,4-dihydrodiolphenanthrene sulfotransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: trans-3,4-dihydrodiolphenanthrene + 2 X-SO3(-) = 2 HX + phenanthrene-3,4-dihydrodiolsulfate conjugate." [UM-BBD_reactionID:r0558]


id: GO:0018726
name: 9-phenanthrol sulfotransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 9-phenanthrol + X-SO3(-) = HX + 9-phenanthrylsulfate." [UM-BBD_reactionID:r0564]


id: GO:0018727
name: 2-phenanthrol sulfotransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 2-phenanthrol + X-SO3(-) = HX + 2-phenanthrylsulfate." [UM-BBD_reactionID:r0563]


id: GO:0018730
name: glutaconate CoA-transferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: acetyl-CoA + (E)-glutaconate = acetate + glutaconyl-1-CoA." [EC:2.8.3.12]


id: GO:0018731
name: 1-oxa-2-oxocycloheptane lactonase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 1-oxa-2-oxocycloheptane + H2O = 6-hydroxyhexanoate." [UM-BBD_reactionID:r0167]


id: GO:0018732
name: sulfolactone hydrolase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 4-sulfolactone + OH- = HSO3(-) + maleylacetate." [UM-BBD_reactionID:r0583]


id: GO:0018733
name: 3,4-dihydrocoumarin hydrolase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 3,4-dihydrocoumarin + H2O = 3-(2-hydroxyphenyl) propionate." [UM-BBD_reactionID:r0419]


id: GO:0018736
name: 6-oxo-2-hydroxycyclohexane-1-carboxyl-CoA hydrolase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 6-oxo-2-hydroxycyclohexane-1-carboxyl-CoA + H2O = 3-hydroxypimeloyl-CoA." [UM-BBD_reactionID:r0206]


id: GO:0018737
name: 2-ketocyclohexane-1-carboxyl-CoA hydrolase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 2-ketocyclohexane-1-carboxyl-CoA + H2O = pimeloyl-CoA." [UM-BBD_reactionID:r0193]


id: GO:0018738
name: S-formylglutathione hydrolase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: S-formylglutathione + H(2)O = formate + glutathione + H(+)." [EC:3.1.2.12, RHEA:14964]


id: GO:0018739
name: 4-hydroxybenzoyl-CoA thioesterase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 4-hydroxybenzoyl-CoA + H(2)O = 4-hydroxybenzoate + CoA + H(+)." [EC:3.1.2.23, RHEA:11951]


id: GO:0018740
name: 2'-hydroxybiphenyl-2-sulfinate desulfinase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 2'-hydroxybiphenyl-2-sulfinate + H(2)O = biphenyl-2-ol + sulfite." [EC:3.13.1.3, RHEA:12948]


id: GO:0018741
name: alkyl sulfatase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: dodecyl sulfate + H2O = sulfate + H+ + 1-dodecanol." [UM-BBD_reactionID:r0602]


id: GO:0018742
name: epoxide hydrolase B activity
namespace: molecular_function
def:
  "Catalysis of the hydrolysis of the ether in chloro- or hydroxyepoxypropane to produce chloropropane diol or glycerol. Acts on R enantiomers." [UM-BBD_enzymeID:e0051]


id: GO:0018743
name: phenanthrene-9,10-epoxide hydrolase (9R,10R-forming) activity
namespace: molecular_function
def:
  "Catalysis of the reaction: phenanthrene-9,10-oxide + H2O = trans-9R,10R-dihydrodiolphenanthrene." [UM-BBD_reactionID:r0560]


id: GO:0018744
name: limonene-1,2-epoxide hydrolase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: limonene-1,2-epoxide + H2O = limonene-1,2-diol. Other substrates include alicyclic and 1-methyl-substituted epoxides, such as 1-methylcyclohexene oxide, indene oxide and cyclohexene oxide." [EC:3.3.2.8]


id: GO:0018745
name: epoxide hydrolase A activity
namespace: molecular_function
def:
  "Catalysis of the hydrolysis of the ether in chloro-, bromo- or hydroxyepoxypropane to produce a chloro- or bromopropane diol or glycerol." [UM-BBD_enzymeID:e0049]


id: GO:0018746
name: phenanthrene-3,4-epoxide hydrolase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: phenanthrene-3,4-oxide + H2O = trans-3,4-dihydrodiolphenanthrene." [UM-BBD_reactionID:r0535]


id: GO:0018747
name: phenanthrene-1,2-epoxide hydrolase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: phenanthrene-1,2-oxide + H2O = trans-1,2-dihydrodiolphenanthrene." [UM-BBD_reactionID:r0536]


id: GO:0018748
name: iprodione amidohydrolase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: iprodione + OH- = 3,5-dichlorophenylcarboximide + N-isopropylcarbamate." [UM-BBD_reactionID:r0706]


id: GO:0018749
name: (3,5-dichlorophenylurea)acetate amidohydrolase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: (3,5-dichlorophenylurea)acetate + OH- = 3,5-dichloroaniline + N-carboxyglycine." [UM-BBD_reactionID:r0708]


id: GO:0018751
name: 3,5-dichlorophenylcarboximide hydrolase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 3,5-dichlorophenylcarboximide + OH- = (3,5-dichlorophenylurea)acetate." [UM-BBD_reactionID:r0707]


id: GO:0018752
name: epsilon-caprolactam lactamase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: epsilon-caprolactam + H2O = H+ + 6-aminohexanoate." [UM-BBD_reactionID:r0448]


id: GO:0018755
name: 2-chloro-4-hydroxy-6-amino-1,3,5-triazine aminohydrolase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 2-chloro-4-hydroxy-6-amino-1,3,5-triazine + OH- = 2,4-dihydroxy-6-amino-1,3,5-triazine + Cl-." [UM-BBD_reactionID:r1414]


id: GO:0018757
name: deisopropylhydroxyatrazine aminohydrolase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: deisopropylhydroxyatrazine + H2O = NH3 + 2,4-dihydroxy-6-(N'-ethyl)amino-1,3,5-triazine." [UM-BBD_reactionID:r0121]


id: GO:0018758
name: 2,4-dihydroxy-6-(N'-ethyl)amino-1,3,5-triazine aminohydrolase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 2,4-dihydroxy-6-(N'-ethyl)amino-1,3,5-triazine + H2O = CH3CH2NH2 + cyanuric acid." [UM-BBD_reactionID:r0122]


id: GO:0018759
name: methenyltetrahydromethanopterin cyclohydrolase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 5,10-methenyl-5,6,7,8-tetrahydromethanopterin + H(2)O = N(5)-formyl-5,6,7,8-tetrahydromethanopterin + H(+)." [EC:3.5.4.27, RHEA:19056]


id: GO:0018760
name: thiocyanate hydrolase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: H(2)O + 2 H(+) + thiocyanate = carbonyl sulfide + NH(4)(+)." [EC:3.5.5.8, RHEA:21467]


id: GO:0018761
name: bromoxynil nitrilase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 3,5-dibromo-4-hydroxybenzonitrile + 2 H(2)O = 3,5-dibromo-4-hydroxybenzoate + NH(4)(+). Involved in the bacterial degradation of the herbicide bromoxynil." [EC:3.5.5.6, RHEA:22103]


id: GO:0018763
name: hydroxydechloroatrazine ethylaminohydrolase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 4-(ethylamino)-2-hydroxy-6-(isopropylamino)-1,3,5-triazine + H2O = N-isopropylammelide + ethylamine." [EC:3.5.99.3]


id: GO:0018764
name: N-isopropylammelide isopropylaminohydrolase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: N-isopropylammelide + H2O = cyanuric acid + isopropylamine." [EC:3.5.99.4]


id: GO:0018765
name: 2-hydroxy-6-oxohepta-2,4-dienoate hydrolase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: cis,cis-2-hydroxy-6-oxohept-2,4-dienoate + OH- = cis-2-hydroxypenta-2,4-dienoate + acetate." [UM-BBD_reactionID:r0263]


id: GO:0018766
name: dihydrophloroglucinol hydrolase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: dihydrophloroglucinol + OH- = 3-hydroxy-5-oxohexanoate." [UM-BBD_reactionID:r0008]


id: GO:0018767
name: 2-hydroxy-6-oxo-7-methylocta-2,4-dienoate hydrolase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 2-hydroxy-6-oxo-7-methylocta-2,4-dienoate + H2O = cis-2-hydroxypenta-2,4-dienoate + isobutyrate." [UM-BBD_reactionID:r0399]


id: GO:0018768
name: 2-hydroxy-6-oxo-6-(2'-aminophenyl)hexa-2,4-dienoate hydrolase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 2-hydroxy-6-oxo-(2'-aminophenyl)-hexa-2,4-dienoate + H2O = 2-aminobenzoate + cis-2-hydroxypenta-2,4-dienoate." [UM-BBD_reactionID:r0458]


id: GO:0018769
name: 2-hydroxy-6-oxoocta-2,4-dienoate hydrolase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 2-hydroxy-6-oxoocta-2,4-dienoate + H2O = H+ + propanoate + cis-2-hydroxypenta-2,4-dienoate." [UM-BBD_reactionID:r0311]


id: GO:0018770
name: 6-oxo-2-hydroxy-7-(4'-chlorophenyl)-3,8,8-trichloroocta-2E,4E,7-trienoate hydrolase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 6-oxo-2-hydroxy-7-(4'-chlorophenyl)-3,8,8-trichloroocta-2Z,4Z,7-trienoate + H2O = 2-(4'-chlorophenyl)-3,3-dichloropropenoate + cis-2-Hydroxy-3-chloropenta-2,4-dienone + H+." [UM-BBD_reactionID:r0444]


id: GO:0018771
name: 2-hydroxy-6-oxonona-2,4-dienedioate hydrolase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: (2E,4Z)-2-hydroxy-6-oxonona-2,4-dienedioate + H2O = (2E)-2-hydroxypenta-2,4-dienoate + H+ + succinate." [RHEA:24792]


id: GO:0018772
name: trioxoheptanoate hydrolase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 2,4,6-trioxoheptanoate + H2O = acetylpyruvate + acetate." [MetaCyc:R306-RXN, UM-BBD_reactionID:r0094]


id: GO:0018773
name: acetylpyruvate hydrolase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: acetylpyruvate + H(2)O = acetate + H(+) + pyruvate." [EC:3.7.1.6, RHEA:16100]


id: GO:0018774
name: 2,6-dioxo-6-phenylhexa-3-enoate hydrolase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 2,6-dioxo-6-phenylhexa-3-enoate + H2O = benzoate + 2-oxopent-4-enoate." [EC:3.7.1.8]


id: GO:0018775
name: 2-hydroxymuconate-semialdehyde hydrolase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 2-hydroxymuconate semialdehyde + H2O = formate + 2-oxopent-4-enoate." [EC:3.7.1.9]


id: GO:0018776
name: trans-chloroacrylic acid dehalogenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: trans-3-chloroacrylic acid + H2O = H+ + malonate semialdehyde." [UM-BBD_reactionID:r0689]


id: GO:0018777
name: 1,3,4,6-tetrachloro-1,4-cyclohexadiene halidohydrolase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: alkyl halide + H2O = alcohol + HCl. Substrates are 1,3(R),4,6(R)-tetrachloro-1,4-cyclohexadiene (forms 2,4,5-trichloro-2,5-cyclohexadiene-1-ol) and 2,4,5-trichloro-2,5-cyclohexadiene-1-ol (forms 2,5-dichloro-2,5-cyclohexadiene-1,4-diol)." [PMID:10464214]


id: GO:0018778
name: DL-2 haloacid dehalogenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: trichloroacetate + 2 H2O = 3 H+ + 3 Cl- + oxalate." [UM-BBD_reactionID:r0382]


id: GO:0018781
name: S-triazine hydrolase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 1-halo or 1-pseudohalo-S-triazine = 1-hydroxy-S-triazine." [UM-BBD_ruleID:bt0330]


id: GO:0018782
name: cis-chloroacrylic acid dehalogenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: cis-3-chloroacrylic acid + H2O = H+ + HCl + malonate semialdehyde." [UM-BBD_reactionID:r0688]


id: GO:0018783
name: deisopropyldeethylatrazine hydrolase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: deisopropyldeethylatrazine + H2O = 2-chloro-4-hydroxy-6-amino-1,3,5-triazine + NH3." [UM-BBD_reactionID:0129]


id: GO:0018787
name: 4-chlorobenzoyl-CoA dehalogenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 4-chlorobenzoyl-CoA + H2O = 4-hydroxybenzoyl CoA + chloride." [EC:3.8.1.7]


id: GO:0018788
name: atrazine chlorohydrolase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: atrazine + H(2)O = 4-(ethylamino)-2-hydroxy-6-(isopropylamino)-1,3,5-triazine + chloride + H(+)." [EC:3.8.1.8, RHEA:11315]


id: GO:0018789
name: cyclamate sulfohydrolase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: cyclohexylsulfamate + H(2)O = cyclohexylamine + sulfate." [EC:3.10.1.2, RHEA:18484]


id: GO:0018791
name: 2-hydroxy-3-carboxy-6-oxo-7-methylocta-2,4-dienoate decarboxylase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 2-hydroxy-3-carboxy-6-oxo-7-methylocta-2,4-dienoate = CO2 + 2-hydroxy-6-oxo-7-methylocta-2,4-dienoate." [UM-BBD_reactionID:r0398]


id: GO:0018792
name: bis(4-chlorophenyl)acetate decarboxylase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: bis(4-chlorophenyl)acetate + H+ = CO2 + bis(4-chlorophenyl)methane. Bis(4-chlorophenyl)acetate is also known as DDA; bis(4-chlorophenyl)methane is also known as DDM." [UM-BBD_reactionID:r0520]


id: GO:0018793
name: 3,5-dibromo-4-hydroxybenzoate decarboxylase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 3,5-dibromo-4-hydroxybenzoate + H+ = CO2 + 2,6-dibromophenol." [UM-BBD_reactionID:r0546]


id: GO:0018794
name: 2-hydroxyisobutyrate decarboxylase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 2-hydroxyisobutyrate + H+ = CO2 + 2-propanol." [UM-BBD_reactionID:r0617]


id: GO:0018795
name: 2-hydroxy-2-methyl-1,3-dicarbonate decarboxylase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 2-hydroxy-2-methyl-1,3-dicarbonate + H+ = CO2 + L-lactate." [UM-BBD_reactionID:r0621]


id: GO:0018800
name: 5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 5-oxopent-3-ene-1,2,5-tricarboxylate = 2-oxohept-3-enedioate + CO2." [EC:4.1.1.68]


id: GO:0018801
name: glutaconyl-CoA decarboxylase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: trans-glutaconyl-CoA + H(+) = but-2-enoyl-CoA + CO(2)." [EC:4.1.1.70, RHEA:23975]


id: GO:0018802
name: 2,4-dihydroxyhept-2-ene-1,7-dioate aldolase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 2,4-dihydroxy-hept-trans-2-ene-1,7-dioate = pyruvate + succinic semialdehyde." [UM-BBD_reactionID:r0370]


id: GO:0018803
name: 4-(2-carboxyphenyl)-2-oxobut-3-enoate aldolase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: (3E)-4-(2-carboxyphenyl)-2-oxobut-3-enoate = 2-carboxybenzaldehyde + pyruvate." [EC:4.1.2.34]


id: GO:0018807
name: 6-hydroxycyclohex-1-ene-1-carboxyl-CoA hydratase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 6-hydroxycyclohex-1-ene-1-carboxyl-CoA + H2O = 2,6-dihydroxycyclohexane-1-carboxyl-CoA." [UM-BBD_reactionID:r0204]


id: GO:0018808
name: trans-4-(1'-hydroxynaphth-2'-yl)-2-oxobut-3-enoate hydratase-aldolase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: trans-4-(1'-hydroxynaphth-2'-yl)-2-oxobut-3-enoate + H2O = pyruvate + 1-hydroxy-2-naphthaldehyde." [UM-BBD_reactionID:r0484]


id: GO:0018809
name: E-phenylitaconyl-CoA hydratase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: E-phenylitaconyl-CoA + H2O = (hydroxymethylphenyl)succinyl-CoA." [UM-BBD_reactionID:r0331]


id: GO:0018810
name: trans-4-[2-(3-hydroxy)-thionaphthenyl]-2-oxo-3-butenoate hydratase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: trans-4-(2-(3-hydroxy)-thionaphthenyl)-2-oxo-3-butenoate + H2O = pyruvate + 3-hydroxy-2-formylbenzothiophene." [UM-BBD_reactionID:r0164]


id: GO:0018811
name: cyclohex-1-ene-1-carboxyl-CoA hydratase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: cyclohex-1-ene-1-carboxyl-CoA + H2O = 2-hydroxycyclohexane-1-carboxyl-CoA." [MetaCyc:R266-RXN, UM-BBD_reactionID:r0191]


id: GO:0018812
name: 3-hydroxyacyl-CoA dehydratase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: alkene-CoA + H2O = alcohol-CoA. Substrates are crotonoyl-CoA (producing 3-hydroxyacyl-CoA) and 2,3-didehydro-pimeloyl-CoA (producing 3-hydroxypimeloyl-CoA)." [UM-BBD_ruleID:bt0291]


id: GO:0018813
name: trans-o-hydroxybenzylidenepyruvate hydratase-aldolase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 2-oxo-3-enoate-4-benzenoid + H2O = pyruvate + benzaldehyde derivative. Substrates are (3E)-4-(5-amino-2-hydroxy-phenyl)-2-oxo-but-3-ene-1-oic-acid (forms 5-aminosalicylaldehyde) and trans-o-hydroxybenzylidenepyruvate (forms salicylaldehyde)." [UM-BBD_enzymeID:e0257]


id: GO:0018814
name: phenylacetaldoxime dehydratase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: (trans)-phenylacetaldoxime = H(2)O + phenylacetonitrile." [EC:4.99.1.7, RHEA:20072]


id: GO:0018815
name: 3-methyl-5-hydroxy-6-(3-carboxy-3-oxopropenyl)-1H-2-pyridon hydratase-aldolase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 3-methyl-5-hydroxy-6-(3-carboxy-3-oxopropenyl)-1H-2-pyridon + H2O = 2-oxobut-3-enanoate + 2,5,6-trihydroxy-3-methylpyridine." [MetaCyc:RXN-645, UM-BBD_reactionID:r0051]


id: GO:0018817
name: 2-oxo-hept-3-ene-1,7-dioate hydratase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: cis-2-oxohept-3-ene-1,7-dioate + H2O = 2,4-dihydroxy-hept-trans-2-ene-1,7-dioate." [UM-BBD_reactionID:r0369]


id: GO:0018823
name: cyclohexa-1,5-dienecarbonyl-CoA hydratase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: cyclohexa-1,5-diene-1-carbonyl-CoA + H(2)O = 6-hydroxycyclohex-1-enecarbonyl-CoA." [EC:4.2.1.100, RHEA:21859]


id: GO:0018824
name: (hydroxyamino)benzene mutase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: (hydroxyamino)benzene = 2-aminophenol." [EC:5.4.4.1, UM-BBD_reactionID:r0304]


id: GO:0018825
name: triethanolamine lyase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: triethanolamine = diethanolamine + acetaldehyde." [UM-BBD_enzymeID:e0421]


id: GO:0018827
name: 1-chloro-2,2-bis(4-chlorophenyl)ethane dehydrochlorinase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 1-chloro-2,2-bis(4-chlorophenyl)ethane = HCl + unsym-bis(4-chlorophenyl)ethene. 1-chloro-2,2-bis(4-chlorophenyl)ethane is also known as DDMS; unsym-bis(4-chlorophenyl)ethene is also known as DDNU." [UM-BBD_reactionID:r0515]


id: GO:0018828
name: halohydrin hydrogen-halide-lyase A activity
namespace: molecular_function
def:
  "Catalysis of the elimination of HCl from a chloro- or bromopropanol, yielding an epoxypropane." [UM-BBD_enzymeID:e0048]


id: GO:0018829
name: 1,1-dichloro-2,2-bis(4-chlorophenyl)ethane dehydrochlorinase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 1,1-dichloro-2,2-bis(4-chlorophenyl)ethane = HCl + 1-chloro-2,2-bis(4-chlorophenyl)ethene. 1,1-dichloro-2,2-bis(4-chlorophenyl)ethane is also known as DDD; 1-chloro-2,2-bis(4-chlorophenyl)ethene is also known as DDMU." [UM-BBD_reactionID:r0513]


id: GO:0018830
name: gamma-hexachlorocyclohexane dehydrochlorinase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: gamma-hexachlorocyclohexane + HCl = 1,3(R),4(S),5(S),6(R)-pentachlorocyclohexene." [UM-BBD_enzymeID:e0359]


id: GO:0018831
name: 5-chloro-1,2,4-trihydroxybenzene dechlorinase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 5-chloro-1,2,4-trihydroxybenzene = Cl- + H+ + 2-hydroxy-1,4-benzoquinone." [UM-BBD_reactionID:r0666]


id: GO:0018832
name: halohydrin hydrogen-halide-lyase B activity
namespace: molecular_function
def:
  "Catalysis of the elimination of HCl from a chloropropanol, yielding an epoxypropane." [UM-BBD_enzymeID:e0050]


id: GO:0018833
name: DDT-dehydrochlorinase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 1,1,1-trichloro-2,2-bis(4-chlorophenyl)ethane = 1,1-dichloro-2,2-bis(4-chlorophenyl)ethylene + chloride + H(+)." [EC:4.5.1.1, RHEA:19220]


id: GO:0018834
name: dichloromethane dehalogenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: dichloromethane + H(2)O = 2 chloride + formaldehyde + 2 H(+)." [EC:4.5.1.3, RHEA:15400]


id: GO:0018835
name: carbon phosphorus lyase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: alkylphosphonic acid = R-CH3 + phosphate. Substrates include aminomethylphosphonic acid (AMPA) (forms methylamine), dimethylphosphinic acid (forms methylphosphonic acid), glyphosate (forms sarcosine) and methylphosphonic acid (forms phosphate)." [PMID:3804975]


id: GO:0018837
name: 2-hydroxy-2H-benzo[h]chromene-2-carboxylate isomerase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 2-hydroxy-2 H-benzo[h]chromene-2-carboxylate = cis -4-(1'-hydroxynaphth-2'-yl)-2-oxobut-3-enoate." [UM-BBD_reactionID:r0502]


id: GO:0018839
name: cis-4-[2-(3-hydroxy)-thionaphthenyl]-2-oxo-3-butenoate isomerase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: cis-4-(2-(3-hydroxy)-thionaphthenyl)-2-oxo-3-butenoate = trans-4-(2-(3-hydroxy)-thionaphthenyl)-2-oxo-3-butenoate." [UM-BBD_reactionID:r0163]


id: GO:0018844
name: 2-hydroxytetrahydrofuran isomerase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 2-hydroxytetrahydrofuran = 4-hydroxybutyraldehyde." [UM-BBD_reactionID:r0019]


id: GO:0018845
name: 2-hydroxychromene-2-carboxylate isomerase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 2-hydroxychromene-2-carboxylate = (3E)-4-(2-hydroxyphenyl)-2-oxobut-3-enoate. (3E)-4-(2-hydroxyphenyl)-2-oxobut-3-enoate is also known as trans-o-hydroxybenzylidenepyruvate." [RHEA:27404]


id: GO:0018849
name: muconate cycloisomerase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 2,5-dihydro-5-oxofuran-2-acetate = cis,cis-hexadienedioate." [EC:5.5.1.1]


id: GO:0018850
name: chloromuconate cycloisomerase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 2-chloro-2,5-dihydro-5-oxofuran-2-acetate = 3-chloro-cis,cis-muconate." [EC:5.5.1.7]


id: GO:0018851
name: alpha-pinene-oxide decyclase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: alpha-pinene oxide = (Z)-2-methyl-5-isopropylhexa-2,5-dienal." [EC:5.5.1.10, RHEA:16696]


id: GO:0018852
name: dichloromuconate cycloisomerase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 2,4-dichloro-2,5-dihydro-5-oxofuran-2-acetate = 2,4-dichloro-cis,cis-muconate." [EC:5.5.1.11]


id: GO:0018853
name: obsolete perillyl-CoA synthetase activity
namespace: molecular_function
def:
  "OBSOLETE. Catalysis of the reaction: perillic acid + CoA-SH + ATP = H2O + ADP/AMP + mono/diphosphate + perillyl-CoA." [UM-BBD_reactionID:r0731]


id: GO:0018854
name: 3-isopropenyl-6-oxoheptanoyl-CoA synthetase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: (3R)-3-isopropenyl-6-oxoheptanoate + CoA-SH + ATP = H2O + ADP/AMP + mono/diphosphate + (3R)-3-isopropenyl-6-oxoheptanoyl-CoA." [UM-BBD_reactionID:r0737]


id: GO:0018855
name: 2-oxo-delta3-4,5,5-trimethylcyclopentenylacetyl-CoA synthetase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 2-oxo-delta3-4,5,5-trimethylcyclopentenylacetate + ATP + CoA = AMP + diphosphate + 2-oxo-delta3-4,5,5-trimethylcyclopentenylacetyl-CoA." [UM-BBD_reactionID:r0429]


id: GO:0018856
name: benzoyl acetate-CoA ligase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 3-oxo-3-phenylpropionate + CoA + ATP = AMP + diphosphate + benzoyl acetyl-CoA." [UM-BBD_reactionID:r0242]


id: GO:0018857
name: 2,4-dichlorobenzoate-CoA ligase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 2,4-dichlorobenzoate + ATP + CoASH = AMP + diphosphate + 2,4-dichlorobenzoyl-CoA." [UM-BBD_reactionID:r0137]


id: GO:0018858
name: benzoate-CoA ligase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: ATP + benzoate + CoA = AMP + benzoyl-CoA + diphosphate + H(+)." [EC:6.2.1.25, RHEA:10135]


id: GO:0018859
name: 4-hydroxybenzoate-CoA ligase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: ATP + 4-hydroxybenzoate + CoA = AMP + diphosphate + 4-hydroxybenzoyl-CoA." [EC:6.2.1.27]


id: GO:0018860
name: anthranilate-CoA ligase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: ATP + anthranilate + CoA = AMP + diphosphate + anthranilyl-CoA." [EC:6.2.1.32]


id: GO:0018861
name: 4-chlorobenzoate-CoA ligase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 4-chlorobenzoate + CoA + ATP = 4-chlorobenzoyl-CoA + AMP + diphosphate. This reaction requires magnesium and is part of the bacterial 2,4-dichlorobenzoate degradation pathway." [EC:6.2.1.33]


id: GO:0018862
name: phenylphosphate carboxylase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: phenylphosphate + CO2 + H2O = H+ + phosphate + 4-hydroxybenzoate." [UM-BBD_reactionID:r0157]


id: GO:0018863
name: phenanthrene-9,10-epoxide hydrolase (9S,10S-forming) activity
namespace: molecular_function
def:
  "Catalysis of the reaction: phenanthrene-9,10-oxide + H2O = trans-9(S),10(S)-dihydrodiolphenanthrene." [UM-BBD_reactionID:r0496]


id: GO:0018864
name: acetylene metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving acetylene, formula CH2CH2, the simplest of the alkynes." [ISBN:0721662544]


id: GO:0018865
name: acrylonitrile metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving acrylonitrile, a colorless, volatile liquid with a pungent odor. Acrylonitrile is used in the production of acrylic fibers, plastics, and synthetic rubbers." [http://www.iversonsoftware.com/reference/chemistry/a/acrylonitrile.htm]


id: GO:0018866
name: adamantanone metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving adamantanone, tricyclo(3.3.1.13,7)decanone, a white crystalline solid used as an intermediate for microelectronics in the production of photoresists." [GOC:ai]


id: GO:0018867
name: alpha-pinene metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving alpha-pinene, a monoterpene that may be a significant factor affecting bacterial activities in nature. It is a major component in tea-tree oils, and gives off a piney smelling odor." [UM-BBD_pathwayID:apn]


id: GO:0018868
name: 2-aminobenzenesulfonate metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving 2-aminobenzenesulfonate, aniline-o-sulfonic acid, an aromatic sulfonate used in organic synthesis and in the manufacture of various dyes and medicines." [UM-BBD_pathwayID:abs]


id: GO:0018870
name: anaerobic 2-aminobenzoate metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the breakdown of 2-aminobenzoate, a derivative of benzoic acid with an NH2 group attached to C2, that occurs in the absence of oxygen." [GOC:ai]


id: GO:0018871
name: 1-aminocyclopropane-1-carboxylate metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving 1-aminocyclopropane-1-carboxylate, the anion of 1-aminocyclopropane-1-carboxylic acid, a natural product found in plant tissues. It is a key intermediate in the biosynthesis of ethylene (ethene), a fruit-ripening hormone in plants." [UM-BBD_pathwayID:acp]


id: GO:0018872
name: arsonoacetate metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving arsonoacetate, a synthetic, organic compound containing a single arsenic atom. Arsonoacetate and other arsenic containing compounds are used in agricultural applications as animal feed additives, cotton defoliants and post-emergence grass herbicides." [UM-BBD_pathwayID:ara]


id: GO:0018873
name: atrazine metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving atrazine, a triazine ring-containing compound, widely used as a herbicide." [UM-BBD_pathwayID:atr]


id: GO:0018874
name: benzoate metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving benzoate, the anion of benzoic acid (benzenecarboxylic acid), a fungistatic compound widely used as a food preservative; it is conjugated to glycine in the liver and excreted as hippuric acid." [ISBN:0721662544]


id: GO:0018875
name: anaerobic benzoate metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving benzoate, the anion of benzoic acid (benzenecarboxylic acid) that occur in the absence of oxygen." [GOC:ai]


id: GO:0018876
name: benzonitrile metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving benzonitrile. Benzonitrile is used as a solvent and chemical intermediate in the pharmaceutical, dyestuffs and rubber industries. It is highly toxic and harmful in contact with skin." [UM-BBD_pathwayID:bzn]


id: GO:0018877
name: beta-1,2,3,4,5,6-hexachlorocyclohexane metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving beta-1,2,3,4,5,6-hexachlorocyclohexane, a halogenated organic insecticide that has been used worldwide for agriculture and public health." [UM-BBD_pathwayID:hch]


id: GO:0018878
name: aerobic beta-1,2,3,4,5,6-hexachlorocyclohexane metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving beta-1,2,3,4,5,6-hexachlorocyclohexane that occur in presence of oxygen." [GOC:ai]


id: GO:0018879
name: biphenyl metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving biphenyl, a toxic aromatic hydrocarbon used as a heat transfer agent, as a fungistat in packaging citrus fruits and in plant disease control. Biphenyl can be chlorinated with 1-10 chlorine molecules to form polychlorinated biphenyls (PCBs)." [GOC:jl]


id: GO:0018880
name: 4-chlorobiphenyl metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving 4-chlorobiphenyl, a member of the polychlorinated biphenyl (PCB) group of compounds, a very stable group of synthetic organic compounds composed of a biphenyl nucleus with 1-10 chlorine substituents. 4-chlorobiphenyl has been used as a model substrate to investigate PCB degradation." [GOC:jl]


id: GO:0018881
name: bromoxynil metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving bromoxynil, C7H3Br2NO, a dibrominated phenol derivative with a cyano (-CN) group attached. Bromoxynil is used as a herbicide for post-emergent control of annual broadleaf weeds and works by inhibiting photosynthesis in the target plants." [GOC:ai]


id: GO:0018882
name: (+)-camphor metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving (+)-camphor, a bicyclic monoterpene ketone which is one of the major components in the leaves of common sage. Camphor exists in two enantiomers, but the (+)-isomer is more widely distributed." [UM-BBD_pathwayID:cam]


id: GO:0018883
name: caprolactam metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving caprolactam, hexahydro-2h-azepin-2-one, a cyclic amide of caproic acid used in manufacture of synthetic fibers of the polyamide type. It can cause local irritation." [CHEBI:23000, GOC:curators]


id: GO:0018884
name: carbazole metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving carbazole, a heterocyclic aromatic compound containing a dibenzopyrrole system that is produced during coal gasification and is present in cigarette smoke. Coal tar produced at high temperature contains an average of 1.5% carbazole. It is used widely in synthesis of dyes, pharmaceuticals, and plastics and is a suspected carcinogen." [GOC:jl]


id: GO:0018885
name: carbon tetrachloride metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving carbon tetrachloride, a toxic, carcinogenic compound which is used as a general solvent in industrial degreasing operations. It is also used as grain fumigant and a chemical intermediate in the production of refrigerants." [UM-BBD_pathwayID:ctc]


id: GO:0018886
name: anaerobic carbon tetrachloride metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving carbon tetrachloride, a toxic, carcinogenic compound which is used as a general solvent in industrial degreasing operations, that occur in the absence of oxygen." [GOC:ai]


id: GO:0018887
name: 4-carboxy-4'-sulfoazobenzene metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving 4-carboxy-4'-sulfoazobenzene, a sulfonated azo compound synthesized by nitro-amine condensation from sulfanilic acid and 4-nitrobenzoic acid." [PMID:9603860]


id: GO:0018888
name: 3-chloroacrylic acid metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving 3-chloroacrylic acid, ClHC=CHCOOH, a chlorinated derivative of acrylic acid." [GOC:ai]


id: GO:0018889
name: 2-chloro-N-isopropylacetanilide metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving 2-chloro-N-isopropylacetanilide, an acylanide herbicide widely used to protect corn, onion, cabbage, rose bushes, and ornamental plants." [UM-BBD_pathwayID:ppc]


id: GO:0018890
name: cyanamide metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving cyanamide, NCNH2, a cyanide compound which has been used as a fertilizer, defoliant and in many manufacturing processes. It often occurs as the calcium salt, sometimes also referred to as cyanamide. The citrated calcium salt is used in the treatment of alcoholism." [CHEBI:16698, GOC:curators]


id: GO:0018891
name: cyclohexanol metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving cyclohexanol, the monohydroxy derivative of cyclohexane. It is used as a solvent and blending agent." [ISBN:0721662544]


id: GO:0018892
name: cyclohexylsulfamate metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving cyclohexylsulfamate, also known as cyclamic acid. Sodium cyclohexylsulfamate (CHS-Na) was a widely used sweetening agent but was banned because of the suspicion of carcinogenicity and metabolic conversion to cyclohexylamine (CHA), a toxic substance. It is now used as a fungicide." [UM-BBD_pathwayID:chs]


id: GO:0018893
name: dibenzofuran metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving dibenzofuran, a substance composed of two benzene rings linked by one ether bond and one carbon-carbon bond. Dibenzofuran is a white crystalline solid created from the production of coal tar and used as an insecticide and an intermediate in the production of other chemicals." [GOC:ai, UM-BBD_pathwayID:dbf]


id: GO:0018894
name: dibenzo-p-dioxin metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving dibenzo-p-dioxin, a substance composed of two benzene rings linked by two ether bonds. Dibenzo-p-dioxins are generated as by-products in the manufacturing of herbicides, insecticides, fungicides, paper pulp bleaching, and in incineration, and can accumulate in milk and throughout the food chain, creating significant health concern." [UM-BBD_pathwayID:dpd]


id: GO:0018895
name: dibenzothiophene metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving dibenzothiophene, a substance composed of two benzene rings linked by one sulfide bond and one carbon-carbon bond. Dibenzothiophene derivatives can be detected in diesel oil following hydrodesulfurization treatment to remove sulfur compounds that would otherwise generate sulfur oxides during combustion." [PMID:12147483]


id: GO:0018896
name: dibenzothiophene catabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the breakdown of dibenzothiophene, a substance composed of two benzene rings linked by one sulfide bond and one carbon-carbon bond." [GOC:ai]


id: GO:0018897
name: dibenzothiophene desulfurization
namespace: biological_process
def:
  "The removal of the sulfur atom from dibenzothiophene, a substance composed of two benzene rings linked by one sulfide bond and one carbon-carbon bond." [GOC:ai]


id: GO:0018898
name: 2,4-dichlorobenzoate metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving 2,4-dichlorobenzoate, a chlorinated aromatic compound which is a key intermediate in the aerobic degradation of polychlorinated biphenyls (PCBs)." [GOC:jl, UM-BBD_pathwayID:dcb]


id: GO:0018899
name: 1,2-dichloroethane metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving 1,2-dichloroethane, a major commodity chemical used, for example, in the manufacture of vinyl chloride." [GOC:jl]


id: GO:0018900
name: dichloromethane metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving dichloromethane, a dichlorinated derivative of methane. It is a colorless organic liquid with a sweet, chloroform-like odor, often used as a paint remover." [UM-BBD_pathwayID:dcm]


id: GO:0018901
name: 2,4-dichlorophenoxyacetic acid metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving 2,4-dichlorophenoxyacetic acid, a chlorinated phenoxy compound which functions as a systemic herbicide and is used to control many types of broadleaf weeds." [UM-BBD_pathwayID:2\,4d]


id: GO:0018902
name: 1,3-dichloro-2-propanol metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving 1,3-dichloro-2-propanol (DCP), a halohydrin suspected of being carcinogenic, mutagenic and genotoxic. DCP is used as a general solvent, as an intermediate in organic synthesis and in paints, varnishes, lacquers, water colors, binders and photographic lacquers." [GOC:jl, UM-BBD_pathwayID:dcp]


id: GO:0018903
name: 1,3-dichloropropene metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving members of the 1,3-dichloropropene family, which includes cis- and trans-1,3-dichloropropene. The 1,3-dichloropropenes are chlorinated hydrocarbons and the major active ingredients of commercial products for control of plant-parasitic nematodes." [UM-BBD_pathwayID:cpr]


id: GO:0018904
name: ether metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving organic ethers, any anhydride of the general formula R1-O-R2, formed between two identical or nonidentical organic hydroxy compounds." [GOC:pr, ISBN:0198506732]


id: GO:0018905
name: dimethyl ether metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving dimethyl ether, CH3-O-CH3, the simplest ether. Dimethyl ether, also known wood ether and methyl ether, is a colorless gas that has been used in refrigeration applications." [UM-BBD_pathwayID:dme]


id: GO:0018906
name: methyl tert-butyl ether metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving methyl tert-butyl ether, 2-methoxy-2-methylpropane. Methyl tert-butyl ether is a synthetic chemical which is mixed with gasoline for use in reformulated gasoline. It was first introduced as an additive for unleaded gasoline in the 1980s. It is also used as a laboratory reagent and a pharmaceutical agent." [UM-BBD_pathwayID:mtb]


id: GO:0018907
name: dimethyl sulfoxide metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving dimethyl sulfoxide, DMSO (C2H6OS), an alkyl sulfoxide that is practically odorless in its purified form. As a highly polar organic liquid, it is a powerful solvent. Its biological activities include the ability to penetrate plant and animal tissues and to preserve living cells during freezing." [CHEBI:28262, GOC:curators]


id: GO:0018908
name: organosulfide cycle
namespace: biological_process
def:
  "A cyclic series of interconversions involving dimethyl sulfide, methanethiol and hydrogen sulfide. Dimethylsulfoxide can also be converted to dimethyl sulfide, which enters the cycle." [UM-BBD_pathwayID:sulf]


id: GO:0018909
name: dodecyl sulfate metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving dodecyl sulfate, commonly found as sodium dodecyl sulfate (SDS), a component of a variety of synthetic surfactants." [UM-BBD_pathwayID:dds]


id: GO:0018910
name: benzene metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving benzene, C6H6, a volatile, very inflammable liquid, contained in the naphtha produced by the destructive distillation of coal, from which it is separated by fractional distillation." [CHEBI:16716, GOC:ai]


id: GO:0018911
name: 1,2,4-trichlorobenzene metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving 1,2,4-trichlorobenzene, a derivative of benzene with chlorine atoms attached to positions 1, 2 and 4 of the ring. It is a colorless liquid used as a solvent in chemical manufacturing, in dyes and intermediates, dielectric fluid, synthetic transformer oils, lubricants, heat-transfer medium and insecticides." [http://www.speclab.com/compound/c120821.htm]


id: GO:0018912
name: 1,4-dichlorobenzene metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving 1,4-dichlorobenzene (p-dichlorobenzene or paramoth), a derivative of benzene with two chlorine atoms attached at opposite positions on the ring. It forms white crystals at room temperature and is used as an insecticidal fumigant, particularly in mothballs." [http://www.speclab.com/compound/c106467.htm]


id: GO:0018913
name: anaerobic ethylbenzene metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving ethylbenzene (phenylethane), a benzene derivative with an ethyl group attached to the ring, that occur in the absence of oxygen." [GOC:ai]


id: GO:0018914
name: chlorobenzene metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving chlorobenzene, a derivative of benzene with a chlorine atoms attached to the ring. It is a colorless liquid that is manufactured for use as a solvent. It quickly evaporates in the air and is degraded by hydroxyl radicals that are produced photochemically. The gas acts as a source of ClOx, which helps in the breakdown of stratospheric ozone." [http://www.shsu.edu/]


id: GO:0018915
name: ethylbenzene metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving ethylbenzene (phenylethane), a benzene derivative with an ethyl group attached to the ring. It is a colorless liquid with a pungent odor used as a solvent and as a component of automotive and aviation fuels." [http://www.speclab.com/compound/c100414.htm]


id: GO:0018916
name: nitrobenzene metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving nitrobenzene (nitrobenzol), a derivative of benzene with an NO2 group attached to the ring. It is a yellow aromatic liquid used in perfumery and manufactured in large quantities in the preparation of aniline." [CHEBI:27798, GOC:curators]


id: GO:0018917
name: fluorene metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving fluorene, a tricyclic polycyclic aromatic hydrocarbon containing a five-membered ring. It is a major component of fossil fuels and their derivatives and is also a by-product of coal-conversion and energy-related industries. It is commonly found in vehicle exhaust emissions, crude oils, motor oils, coal and oil combustion products, waste incineration, and industrial effluents." [UM-BBD_pathwayID:flu]


id: GO:0018918
name: gallate metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving gallate, the anion of gallic acid (3,4,5-trihydroxybenzoic acid). The esters and polyesters are widely distributed in angiosperms." [GOC:jl, ISBN:0198506732]


id: GO:0018919
name: gamma-1,2,3,4,5,6-hexachlorocyclohexane metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving gamma-1,2,3,4,5,6-hexachlorocyclohexane (also known as Lindane), the most common form of hexachlorohexane, a halogenated organic insecticide that has been used worldwide for agriculture and public health." [UM-BBD_pathwayID:ghch]


id: GO:0018920
name: glyphosate metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving glyphosate, a broad-spectrum herbicide also known by the trade name Roundup. It is a member of a broad class of compounds known as phosphonic acids, which contain a direct carbon-to-phosphorus (C-P) bond." [UM-BBD_pathwayID:gly]


id: GO:0018921
name: 3-hydroxybenzyl alcohol metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving 3-hydroxybenzyl alcohol, an aromatic compound which is an intermediate in several metabolic pathways, including the biosynthesis of patulin, a toxin and antiviral agent produced by some moulds such as Penicillium patulinum." [UM-BBD_pathwayID:mcr]


id: GO:0018922
name: iprodione metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving prodione, a colorless, odorless crystal. It is used as a dicarboximide contact fungicide to control a wide variety of crop diseases by inhibiting the germination of spores and the growth of the fungal mat (mycelium)." [UM-BBD_pathwayID:ipd]


id: GO:0018923
name: limonene metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving limonene (4-isopropenyl-1-methyl-cyclohexene), a monocyclic monoterpene." [UM-BBD_pathwayID:lim]


id: GO:0018924
name: mandelate metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving mandelate, the anion of mandelic acid. Mandelic acid (alpha-hydroxybenzeneacetic acid) is an 8-carbon alpha-hydroxy acid (AHA) that is used in organic chemistry and as a urinary antiseptic." [GOC:jl]


