# go

id: GO:0021757
name: caudate nucleus development
namespace: biological_process
def:
  "The progression of the caudate nucleus over time from its initial formation until its mature state. The caudate nucleus is the C-shaped structures of the striatum containing input neurons involved with control of voluntary movement in the brain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0878937420]


id: GO:0021758
name: putamen development
namespace: biological_process
def:
  "The progression of the putamen over time from its initial formation until its mature state. The putamen is the lens-shaped basal ganglion involved with control of voluntary movement in the brain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0878937420]


id: GO:0021759
name: globus pallidus development
namespace: biological_process
def:
  "The progression of the globus pallidus over time from its initial formation until its mature state. The globus pallidus is one of the basal ganglia involved with control of voluntary movement in the brain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0878937420]


id: GO:0021761
name: limbic system development
namespace: biological_process
def:
  "The progression of the limbic system over time from its initial formation until its mature state. The limbic system is a collection of structures in the brain involved in emotion, motivation and emotional aspects of memory." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0878937420]


id: GO:0021762
name: substantia nigra development
namespace: biological_process
def:
  "The progression of the substantia nigra over time from its initial formation until its mature state. The substantia nigra is the layer of gray substance that separates the posterior parts of the cerebral peduncles (tegmentum mesencephali) from the anterior parts; it normally includes a posterior compact part with many pigmented cells (pars compacta) and an anterior reticular part whose cells contain little pigment (pars reticularis)." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343, ISBN:0878937420]


id: GO:0021763
name: subthalamic nucleus development
namespace: biological_process
def:
  "The progression of the subthalamic nucleus over time from its initial formation until its mature state. The subthalamic nucleus is the lens-shaped nucleus located in the ventral part of the subthalamus on the inner aspect of the internal capsule that is concerned with the integration of somatic motor function." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0878937420]


id: GO:0021764
name: amygdala development
namespace: biological_process
def:
  "The progression of the amygdala over time from its initial formation until its mature state. The amygdala is an almond-shaped set of neurons in the medial temporal lobe of the brain that play a key role in processing emotions such as fear and pleasure." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0878937420]


id: GO:0021765
name: cingulate gyrus development
namespace: biological_process
def:
  "The progression of the cingulate gyrus over time from its initial formation until its mature state. The cingulate gyrus is a ridge in the cerebral cortex located dorsal to the corpus callosum." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0878937420]


id: GO:0021766
name: hippocampus development
namespace: biological_process
def:
  "The progression of the hippocampus over time from its initial formation until its mature state." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0878937420, UBERON:0002421]


id: GO:0021767
name: mammillary body development
namespace: biological_process
def:
  "The progression of the mammillary body over time from its initial formation until its mature state. The mammillary body is a protrusion at the posterior end of the hypothalamus that contains hypothalamic nuclei." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0878937420]


id: GO:0021768
name: nucleus accumbens development
namespace: biological_process
def:
  "The progression of the nucleus accumbens over time from its initial formation until its mature state. The nucleus accumbens is a collection of pleomorphic cells in the caudal part of the anterior horn of the lateral ventricle, in the region of the olfactory tubercle, lying between the head of the caudate nucleus and the anterior perforated substance. It is part of the ventral striatum, a composite structure considered part of the basal ganglia." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0878937420]


id: GO:0021769
name: orbitofrontal cortex development
namespace: biological_process
def:
  "The progression of the orbitofrontal cortex over time from its initial formation until its mature state. The orbitofrontal cortex is a cerebral cortex region located in the frontal lobe." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0878937420]


id: GO:0021770
name: parahippocampal gyrus development
namespace: biological_process
def:
  "The progression of the parahippocampal gyrus over time from its initial formation until its mature state. The parahippocampal gyrus is a ridge in the cerebral cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0878937420]


id: GO:0021771
name: lateral geniculate nucleus development
namespace: biological_process
def:
  "The progression of the lateral geniculate nucleus over time from its initial formation until its mature state. The lateral geniculate nucleus is the primary processor of visual information received from the retina." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0878937420]


id: GO:0021772
name: olfactory bulb development
namespace: biological_process
def:
  "The progression of the olfactory bulb over time from its initial formation until its mature state. The olfactory bulb coordinates neuronal signaling involved in the perception of smell. It receives input from the sensory neurons and outputs to the olfactory cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0878937420]


id: GO:0021773
name: striatal medium spiny neuron differentiation
namespace: biological_process
def:
  "The process in which a relatively unspecialized cell acquires specialized features of a medium spiny neuron residing in the striatum." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0878937420]


id: GO:0021774
name: retinoic acid receptor signaling pathway involved in ventral spinal cord interneuron specification
namespace: biological_process
def:
  "The series of molecular signals initiated by binding of a ligand to a retinoic acid receptor in a precursor cell in the ventral spinal cord that contributes to the commitment of the precursor cell to an interneuron fate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, GOC:sdb_2009, GOC:tb, PMID:11262869]


id: GO:0021775
name: smoothened signaling pathway involved in ventral spinal cord interneuron specification
namespace: biological_process
def:
  "The series of molecular signals initiated by binding of a ligand to the transmembrane receptor smoothened in a precursor cell in the ventral spinal cord that contributes to the commitment of the precursor cell to an interneuron fate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:11262869]


id: GO:0021776
name: smoothened signaling pathway involved in spinal cord motor neuron cell fate specification
namespace: biological_process
def:
  "The series of molecular signals initiated by binding of a ligand to the transmembrane receptor smoothened in a precursor cell in the spinal cord that contributes to the process of a precursor cell becoming capable of differentiating autonomously into a motor neuron in an environment that is neutral with respect to the developmental pathway." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:15936325]


id: GO:0021777
name: BMP signaling pathway involved in spinal cord association neuron specification
namespace: biological_process
def:
  "A series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, which contributes to its commitment to an association neuron fate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12593981]


id: GO:0021778
name: oligodendrocyte cell fate specification
namespace: biological_process
def:
  "The process in which a cell becomes capable of differentiating autonomously into an oligodendrocyte in an environment that is neutral with respect to the developmental pathway. Upon specification, the cell fate can be reversed." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]


id: GO:0021779
name: oligodendrocyte cell fate commitment
namespace: biological_process
def:
  "The process in which the developmental fate of a cell becomes restricted such that it will develop into an oligodendrocyte." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]


id: GO:0021780
name: glial cell fate specification
namespace: biological_process
def:
  "The process in which a cell becomes capable of differentiating autonomously into a glial cell in an environment that is neutral with respect to the developmental pathway. Upon specification, the cell fate can be reversed." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]


id: GO:0021781
name: glial cell fate commitment
namespace: biological_process
def:
  "The process in which the developmental fate of a cell becomes restricted such that it will develop into a glial cell." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]


id: GO:0021782
name: glial cell development
namespace: biological_process
def:
  "The process aimed at the progression of a glial cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]


id: GO:0021783
name: preganglionic parasympathetic fiber development
namespace: biological_process
def:
  "The process whose specific outcome is the progression of a preganglionic parasympathetic fiber over time, from its formation to the mature structure. A preganglionic parasympathetic fiber is a cholinergic axonal fiber projecting from the CNS to a parasympathetic ganglion." [GO_REF:0000021, GOC:cjm, GOC:cls, GOC:dgh, GOC:dph, GOC:jid]


id: GO:0021784
name: postganglionic parasympathetic fiber development
namespace: biological_process
def:
  "The process whose specific outcome is the progression of the postganglionic portion of the parasympathetic fiber over time, from its formation to the mature structure. The parasympathetic fiber is one of the two divisions of the vertebrate autonomic nervous system. Parasympathetic nerves emerge cranially as pre ganglionic fibers from oculomotor, facial, glossopharyngeal and vagus and from the sacral region of the spinal cord. Most neurons are cholinergic and responses are mediated by muscarinic receptors. The parasympathetic system innervates, for example: salivary glands, thoracic and abdominal viscera, bladder and genitalia." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]


id: GO:0021785
name: branchiomotor neuron axon guidance
namespace: biological_process
def:
  "The process in which a branchiomotor neuron growth cone is directed to a specific target site. Branchiomotor neurons are located in the hindbrain and innervate branchial arch-derived muscles that control jaw movements, facial expression, the larynx, and the pharynx." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:14699587]


id: GO:0021786
name: branchiomotor neuron axon guidance in neural tube
namespace: biological_process
def:
  "The process in which a branchiomotor neuron growth cone in the neural tube is directed to a specific target site in the neural tube. Branchiomotor neurons are located in the hindbrain and innervate branchial arch-derived muscles that control jaw movements, facial expression, the larynx, and the pharynx." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:14699587]


id: GO:0021787
name: chemorepulsion of branchiomotor neuron axon in neural tube
namespace: biological_process
def:
  "The process in which a branchiomotor neuron growth cone in the neural tube is directed to a specific target site in the neural tube in response to a repulsive chemical cue. Branchiomotor neurons are located in the hindbrain and innervate branchial arch-derived muscles that control jaw movements, facial expression, the larynx, and the pharynx." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:14699587]


id: GO:0021788
name: chemoattraction of branchiomotor neuron axon in neural tube
namespace: biological_process
def:
  "The process in which a branchiomotor neuron growth cone in the neural tube is directed to a specific target site in the neural tube in response to an attractive chemical cue. Branchiomotor neurons are located in the hindbrain and innervate branchial arch-derived muscles that control jaw movements, facial expression, the larynx, and the pharynx." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:14699587]


id: GO:0021789
name: branchiomotor neuron axon guidance in branchial arch mesenchyme
namespace: biological_process
def:
  "The process in which a branchiomotor neuron growth cone in the branchial arch mesenchyme is directed to a specific target site in the branchial arch mesenchyme. Branchiomotor neurons are located in the hindbrain and innervate branchial arch-derived muscles that control jaw movements, facial expression, the larynx, and the pharynx." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:14699587]


id: GO:0021790
name: chemorepulsion of branchiomotor neuron axon in branchial arch mesenchyme
namespace: biological_process
def:
  "The process in which a branchiomotor neuron growth cone in the branchial arch mesenchyme is directed to a specific target site in the branchial arch mesenchyme in response to a repulsive chemical cue. Branchiomotor neurons are located in the hindbrain and innervate branchial arch-derived muscles that control jaw movements, facial expression, the larynx, and the pharynx." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:14699587]


id: GO:0021791
name: chemoattraction of branchiomotor neuron axon in branchial arch mesenchyme
namespace: biological_process
def:
  "The process in which a branchiomotor neuron growth cone in the branchial arch mesenchyme is directed to a specific target site in the branchial arch mesenchyme in response to an attractive chemical cue. Branchiomotor neurons are located in the hindbrain and innervate branchial arch-derived muscles that control jaw movements, facial expression, the larynx, and the pharynx." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:14699587]


id: GO:0021792
name: chemoattraction of branchiomotor axon
namespace: biological_process
def:
  "The process in which a branchiomotor neuron growth cone is directed to a specific target site in response to an attractive chemical signal. Branchiomotor neurons are located in the hindbrain and innervate branchial arch-derived muscles that control jaw movements, facial expression, the larynx, and the pharynx." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:14699587]


id: GO:0021793
name: chemorepulsion of branchiomotor axon
namespace: biological_process
def:
  "The process in which a branchiomotor neuron growth cone is directed to a specific target site in response to a repulsive chemical cue. Branchiomotor neurons are located in the hindbrain and innervate branchial arch-derived muscles that control jaw movements, facial expression, the larynx, and the pharynx." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:14699587]


id: GO:0021794
name: thalamus development
namespace: biological_process
def:
  "The process in which the thalamus changes over time, from its initial formation to its mature state." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]


id: GO:0021795
name: cerebral cortex cell migration
namespace: biological_process
def:
  "The orderly movement of cells from one site to another in the cerebral cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]


id: GO:0021796
name: cerebral cortex regionalization
namespace: biological_process
def:
  "The regionalization process that results in the creation of areas within the cerebral cortex that will direct the behavior of cell migration and differentiation as the cortex develops." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]


id: GO:0021797
name: forebrain anterior/posterior pattern specification
namespace: biological_process
def:
  "The creation of specific areas of progenitor domains along the anterior-posterior axis of the developing forebrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]


id: GO:0021798
name: forebrain dorsal/ventral pattern formation
namespace: biological_process
def:
  "The formation of specific regional progenitor domains along the dorsal-ventral axis in the developing forebrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]


id: GO:0021799
name: cerebral cortex radially oriented cell migration
namespace: biological_process
def:
  "The migration of cells in the developing cerebral cortex in which cells move from the ventricular and/or subventricular zone toward the surface of the brain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695]


id: GO:0021800
name: cerebral cortex tangential migration
namespace: biological_process
def:
  "The migration of cells in the cerebral cortex in which cells move orthogonally to the direction of radial migration and do not use radial glial cell processes as substrates for migration." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695]


id: GO:0021801
name: cerebral cortex radial glia guided migration
namespace: biological_process
def:
  "The radial migration of neuronal or glial precursor cells along radial glial cells during the development of the cerebral cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695]


id: GO:0021802
name: somal translocation
namespace: biological_process
def:
  "The radial migration of cells from the ventricular zone that is independent of radial glial cells. Cells extend processes that terminate at the pial surface and follow the processes as they migrate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695]


id: GO:0021803
name: pial surface process extension
namespace: biological_process
def:
  "The extension of a long process to the pial surface as a cell leaves the ventricular zone." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695]


id: GO:0021804
name: negative regulation of cell adhesion in ventricular zone
namespace: biological_process
def:
  "The process that results in the loss of attachments of a cell in the ventricular zone." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695]


id: GO:0021805
name: cell movement involved in somal translocation
namespace: biological_process
def:
  "The movement of a cell body from the ventricular zone to the pial surface with a concomitant shortening of the process that extends to the pial surface." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695]


id: GO:0021806
name: initiation of movement involved in cerebral cortex radial glia guided migration
namespace: biological_process
def:
  "The initial stages of cell motility involved in the glial-mediated movement of cells in the developing cerebral cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695]


id: GO:0021807
name: motogenic signaling initiating cell movement in cerebral cortex
namespace: biological_process
def:
  "The interaction of soluble factors and receptors that result in the movement of cells in the primitive cerebral cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695]


id: GO:0021808
namespace: biological_process
name:
  cytosolic calcium signaling involved in initiation of cell movement in glial-mediated radial cell migration

def:
  "The process that results in the fluctuations in intracellular calcium that are responsible for the initiation of movement as a component of the process of cerebral cortex glial-mediated radial migration." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695]


id: GO:0021809
namespace: biological_process
name:
  neurotrophic factor signaling initiating cell movement, involved in cerebral cortex radial glia guided migration

def:
  "Signaling between members of the neurotrophin family and their receptors that result in the start of cell motility as a component of the process of cerebral cortex glial-mediated radial migration." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695]


id: GO:0021810
namespace: biological_process
name:
  neurotransmitter signaling initiating cell movement, involved in cerebral cortex radial glia guided migration

def:
  "Signaling by neurotransmitters and their receptors that results in the initiation of movement of cells as a component of the process of glial-mediated radial migration." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695]


id: GO:0021811
namespace: biological_process
name:
  growth factor signaling initiating cell movement involved in cerebral cortex radial glia guided migration

def:
  "Signaling between growth factors and their receptors that results in the start of cell movement, where this process is involved in glial-mediated radial migration in the cerebral cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695]


id: GO:0021812
name: neuronal-glial interaction involved in cerebral cortex radial glia guided migration
namespace: biological_process
def:
  "The changes in adhesion between neuronal cells and glial cells as a component of the process of cerebral cortex glial-mediated radial cell migration." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695]


id: GO:0021813
namespace: biological_process
name:
  cell-cell adhesion involved in neuronal-glial interactions involved in cerebral cortex radial glia guided migration

def:
  "The interaction between two cells that modulates the association of a neuronal cell and a glial cell involved in glial-mediated radial cell migration in the cerebral cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695]


id: GO:0021814
name: cell motility involved in cerebral cortex radial glia guided migration
namespace: biological_process
def:
  "The movement of a cell along the process of a radial glial cell involved in cerebral cortex glial-mediated radial migration." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695]


id: GO:0021815
name: modulation of microtubule cytoskeleton involved in cerebral cortex radial glia guided migration
namespace: biological_process
def:
  "Rearrangements of the microtubule cytoskeleton that contribute to the movement of cells along radial glial cells as a component of the process of cerebral cortex glial-mediated radial migration." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695]


id: GO:0021816
namespace: biological_process
name:
  extension of a leading process involved in cell motility in cerebral cortex radial glia guided migration

def:
  "The rearrangements of the microtubule cytoskeleton that result in the extension of a leading process, where this process is involved in the movement of cells along radial glial cells." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695]


id: GO:0021817
name: nucleokinesis involved in cell motility in cerebral cortex radial glia guided migration
namespace: biological_process
def:
  "The microtubule-mediated movement of the nucleus that is required for the movement of cells along radial glial fibers as a component of the process of cerebral cortex glial-mediated radial cell migration." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, GOC:tb, PMID:12626695]


id: GO:0021818
namespace: biological_process
name:
  modulation of the microfilament cytoskeleton involved in cell locomotion in cerebral cortex radial glia guided migration

def:
  "The changes in the actin cytoskeleton that are necessary for the movement of cells along radial glial cells as a component of the process of cerebral cortex glial-mediated radial cell migration." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695]


id: GO:0021819
name: layer formation in cerebral cortex
namespace: biological_process
def:
  "The detachment of cells from radial glial fibers at the appropriate time when they cease to migrate and form distinct layer in the cerebral cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695]


id: GO:0021820
namespace: biological_process
name:
  extracellular matrix organization in marginal zone involved in cerebral cortex radial glia guided migration

def:
  "The process that leads to the deposition of extracellular matrix signals in the marginal zone of the developing cerebral cortex. This extracellular matrix controls the movement of migrating cells. In mammals, the matrix is modified by Cajal-Retzius cells." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695]


id: GO:0021821
name: negative regulation of cell-glial cell adhesion involved in cerebral cortex lamination
namespace: biological_process
def:
  "The process that results in the release of migrating cells from their interaction with radial glial cells as a component of the process of cerebral cortex glial-mediated radial cell migration." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695]


id: GO:0021822
name: negative regulation of cell motility involved in cerebral cortex radial glia guided migration
namespace: biological_process
def:
  "The intracellular signaling pathway that results in the cessation of cell movement involved in lamination of the cerebral cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, GOC:tb, PMID:12626695]


id: GO:0021823
name: cerebral cortex tangential migration using cell-cell interactions
namespace: biological_process
def:
  "The process in which neurons interact with each other to promote migration along a tangential plane." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695]


id: GO:0021824
name: cerebral cortex tangential migration using cell-axon interactions
namespace: biological_process
def:
  "The movement of cerebral cortex neuronal precursors tangentially through the cortex using interaction of the migrating cells with axons of other neurons." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695]


id: GO:0021825
name: substrate-dependent cerebral cortex tangential migration
namespace: biological_process
def:
  "The process where neuronal precursors migrate tangentially in the cerebral cortex, primarily guided through physical cell-cell interactions." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]


id: GO:0021826
name: substrate-independent telencephalic tangential migration
namespace: biological_process
def:
  "The process where neuronal precursors migrate tangentially in the telencephalon, primarily guided by interactions that do not require cell-cell contact." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695]


id: GO:0021827
name: postnatal olfactory bulb interneuron migration
namespace: biological_process
def:
  "The migration of olfactory bulb interneuron precursors in the cerebral cortex that occurs after birth." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695]


id: GO:0021828
name: gonadotrophin-releasing hormone neuronal migration to the hypothalamus
namespace: biological_process
def:
  "The directional movement of a gonadotrophin-releasing hormone producing neuron from the nasal placode to the hypothalamus." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695]


id: GO:0021829
name: oligodendrocyte cell migration from the subpallium to the cortex
namespace: biological_process
def:
  "The directed movement of oligodendrocytes from the subpallium to the cerebral cortex during forebrain development." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695]


id: GO:0021830
name: interneuron migration from the subpallium to the cortex
namespace: biological_process
def:
  "The directed movement of interneurons from the subpallium to the cortex during forebrain development." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695]


id: GO:0021831
name: embryonic olfactory bulb interneuron precursor migration
namespace: biological_process
def:
  "The directed movement of individual interneuron precursors during the embryonic development of the olfactory bulb." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695]


id: GO:0021832
name: cell-cell adhesion involved in cerebral cortex tangential migration using cell-cell interactions
namespace: biological_process
def:
  "The attachment of cells to one another to form groups of cells involved in cerebral cortex tangential migration." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695]


id: GO:0021833
name: cell-matrix adhesion involved in tangential migration using cell-cell interactions
namespace: biological_process
def:
  "The interaction of a cell and the extracellular matrix involved in the directed tangential movement of cells mediated by cell-cell interactions in the developing cerebral cortex." [GO_REF:0000021, GOC:ascb_2009, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, GOC:tb, PMID:12626695]


id: GO:0021834
name: chemorepulsion involved in embryonic olfactory bulb interneuron precursor migration
namespace: biological_process
def:
  "The creation and reception of signals that guide olfactory bulb interneuron precursors down concentration gradients towards the olfactory bulb." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695]


id: GO:0021835
name: chemoattraction involved in embryonic olfactory bulb interneuron precursor migration
namespace: biological_process
def:
  "The creation and reception of signals that result in the migration of interneuron precursors up a concentration gradient towards the olfactory bulb." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695]


id: GO:0021836
name: chemorepulsion involved in postnatal olfactory bulb interneuron migration
namespace: biological_process
def:
  "The creation and reception of signals that repel olfactory bulb interneurons from the subventricular zone as a component process in tangential migration." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695]


id: GO:0021837
name: motogenic signaling involved in postnatal olfactory bulb interneuron migration
namespace: biological_process
def:
  "The signaling that results in the stimulation of cell movement in the rostral migratory stream." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695]


id: GO:0021838
name: motogenic signaling involved in interneuron migration from the subpallium to the cortex
namespace: biological_process
def:
  "The creation and reception of signals that result in the directional movement of interneuron precursors from the subpallium to the cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695]


id: GO:0021839
namespace: biological_process
name:
  interneuron-substratum interaction involved in interneuron migration from the subpallium to the cortex

def:
  "The process in which migrating interneurons interact with an external substratum as a component of migration from the subpallium to the cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695]


id: GO:0021840
name: directional guidance of interneurons involved in migration from the subpallium to the cortex
namespace: biological_process
def:
  "The creation and reception of signals that control the direction of migration of interneurons as a component of the process of migration from the subpallium to the cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695]


id: GO:0021841
name: chemoattraction involved in interneuron migration from the subpallium to the cortex
namespace: biological_process
def:
  "The creation and reception of signals that result in the movement of interneurons toward the signal, where this process is involved in migration from the subpallium to the cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695]


id: GO:0021842
name: chemorepulsion involved in interneuron migration from the subpallium to the cortex
namespace: biological_process
def:
  "The creation and reception of signals that result in the movement of interneurons away from the signal during migration from the subpallium to the cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695]


id: GO:0021843
name: substrate-independent telencephalic tangential interneuron migration
namespace: biological_process
def:
  "The directional movement of tangentially migrating interneurons that are not guided by attaching to extracellular substrates." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695]


id: GO:0021844
name: interneuron sorting involved in substrate-independent cerebral cortex tangential migration
namespace: biological_process
def:
  "The establishment and response to guidance cues that distribute interneurons to different cerebral cortex structures." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695]


id: GO:0021845
namespace: biological_process
name:
  neurotransmitter-mediated guidance of interneurons involved in substrate-independent cerebral cortex tangential migration

def:
  "The response of migrating interneurons to neurotransmitters that alter electrical activity in cells in calcium dependent manner." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695]


id: GO:0021846
name: cell proliferation in forebrain
namespace: biological_process
def:
  "The creation of greater cell numbers in the forebrain due to cell division of progenitor cells." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]


id: GO:0021847
name: ventricular zone neuroblast division
namespace: biological_process
def:
  "The proliferation of neuroblasts in the ventricular zone of the cerebral cortex. The neuronal progenitors of these cells will migrate radially." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695]


id: GO:0021848
name: neuroblast division in subpallium
namespace: biological_process
def:
  "The division of neuroblasts in the subpallium area of the forebrain. The interneuron precursors that these cells give rise to include GABAergic interneurons and will migrate tangentially." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695]


id: GO:0021849
name: neuroblast division in subventricular zone
namespace: biological_process
def:
  "The division of neuroblasts in the subventricular zone of the forebrain. The interneuron precursors that these cells give rise to include adult olfactory bulb interneurons and migrate tangentially." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695]


id: GO:0021850
name: subpallium glioblast cell division
namespace: biological_process
def:
  "The division of glioblasts in the subpallium. These cells will give rise to oligodendrocytes." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695]


id: GO:0021851
name: neuroblast division in dorsal lateral ganglionic eminence
namespace: biological_process
def:
  "The division of neuroblasts in the dorsal region of the lateral ganglionic eminence. These cells give rise to embryonic interneuron precursors that will migrate tangentially to the olfactory bulb." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695]


id: GO:0021852
name: pyramidal neuron migration
namespace: biological_process
def:
  "The migration of pyramidal a neuron precursor from the ventricular zone to the correct layer of the cerebral cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695]


id: GO:0021853
name: cerebral cortex GABAergic interneuron migration
namespace: biological_process
def:
  "The migration of GABAergic interneuron precursors from the subpallium to the cerebral cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695]


id: GO:0021854
name: hypothalamus development
namespace: biological_process
def:
  "The progression of the hypothalamus region of the forebrain, from its initial formation to its mature state." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]


id: GO:0021855
name: hypothalamus cell migration
namespace: biological_process
def:
  "The directed movement of a cell into the hypothalamus region of the forebrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]


id: GO:0021856
name: hypothalamic tangential migration using cell-axon interactions
namespace: biological_process
def:
  "The movement of a hypothalamic neuronal precursor tangentially through the forebrain using an interaction of the migrating cells with axons of other neurons." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]


id: GO:0021858
name: GABAergic neuron differentiation in basal ganglia
namespace: biological_process
def:
  "The process in which a neuroblast acquires the specialized structural and functional features of a GABAergic inhibitory neuron in the basal ganglia. Differentiation includes the processes involved in commitment of a neuroblast to a GABAergic neuron." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:16226447]


id: GO:0021859
name: pyramidal neuron differentiation
namespace: biological_process
def:
  "The process in which a neuroblast or one of its progeny commits to a pyramidal neuron fate, migrates from the ventricular zone to the appropriate layer in the cortex and develops into a mature neuron." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]


id: GO:0021860
name: pyramidal neuron development
namespace: biological_process
def:
  "The progression of a pyramidal neuron from its initial formation to its mature state." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]


id: GO:0021861
name: forebrain radial glial cell differentiation
namespace: biological_process
def:
  "The process in which neuroepithelial cells of the neural tube give rise to radial glial cells, specialized bipotential progenitors cells of the forebrain. Differentiation includes the processes involved in commitment of a cell to a specific fate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:16226447]


id: GO:0021862
name: early neuron differentiation in forebrain
namespace: biological_process
def:
  "The process in which neuroepithelial cells in the neural tube acquire specialized structural and/or functional features of neurons. Differentiation includes the processes involved in commitment of a cell to a specific fate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:16226447]


id: GO:0021863
name: forebrain neuroblast differentiation
namespace: biological_process
def:
  "The process in which neuroepithelial cells in the neural tube acquire specialized structural and/or functional features of basal progenitor cells, neuroblasts that lose their contacts with the ventricular surface. Differentiation includes the processes involved in commitment of a cell to a specific fate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:16226447]


id: GO:0021864
name: radial glial cell division in forebrain
namespace: biological_process
def:
  "The mitotic division of radial glial cells in the developing forebrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:16226447]


id: GO:0021865
name: symmetric radial glial cell division in forebrain
namespace: biological_process
def:
  "The mitotic division of a radial glial cell giving rise to two new radial glial cells in the forebrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:16226447]


id: GO:0021866
name: asymmetric radial glial cell division in forebrain
namespace: biological_process
def:
  "The mitotic cell division of a radial glial cell giving rise to a radial glial cell and another cell type." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:16226447]


id: GO:0021867
name: neuron-producing asymmetric radial glial cell division in forebrain
namespace: biological_process
def:
  "The unequal mitotic division of a radial glial cell in the forebrain that gives rise to a radial glial cell and a post-mitotic neuronal progenitor." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:16226447]


id: GO:0021868
name: ventricular zone cell-producing asymmetric radial glial cell division in forebrain
namespace: biological_process
def:
  "The unequal mitotic division of a forebrain radial glial cell that gives rise to a radial glial cell and a ventricular zone cell." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:16226447]


id: GO:0021869
name: forebrain ventricular zone progenitor cell division
namespace: biological_process
def:
  "The mitotic division of a basal progenitor giving rise to two neurons." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:16226447]


id: GO:0021870
name: Cajal-Retzius cell differentiation
namespace: biological_process
def:
  "The process in which a neuroblast acquires specialized structural and/or functional features of a Cajal-Retzius cell, one of a transient population of pioneering neurons in the cerebral cortex. These cells are slender bipolar cells of the developing marginal zone. One feature of these cells in mammals is that they express the Reelin gene." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]


id: GO:0021871
name: forebrain regionalization
namespace: biological_process
def:
  "The regionalization process resulting in the creation of areas within the forebrain that will direct the behavior of cell migration in differentiation as the forebrain develops." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:isa_complete, GOC:jid, GOC:mtg_15jun06, PMID:16226447]


id: GO:0021872
name: forebrain generation of neurons
namespace: biological_process
def:
  "The process in which nerve cells are generated in the forebrain. This includes the production of neuroblasts from and their differentiation into neurons." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]


id: GO:0021873
name: forebrain neuroblast division
namespace: biological_process
def:
  "The division of a neuroblast located in the forebrain. Neuroblast division gives rise to at least another neuroblast." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]


id: GO:0021874
name: Wnt signaling pathway involved in forebrain neuroblast division
namespace: biological_process
def:
  "The series of molecular signals initiated by binding of Wnt protein to a receptor on the surface of the target cell that contributes to the self renewal of neuroblasts in the forebrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:16226447]


id: GO:0021875
name: fibroblast growth factor receptor signaling pathway involved in forebrain neuroblast division
namespace: biological_process
def:
  "The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands that contributes to the self renewal of neuroblasts in the forebrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:16226447]


id: GO:0021876
name: Notch signaling pathway involved in forebrain neuroblast division
namespace: biological_process
def:
  "The series of molecular signals initiated by binding of an extracellular ligand to a Notch receptor on the surface of the target cell that contributes to the self renewal of neuroblasts in the forebrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:16226447]


id: GO:0021877
name: forebrain neuron fate commitment
namespace: biological_process
def:
  "The process in which the developmental fate of a cell becomes restricted such that it will develop into a neuron that resides in the forebrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:16226447]


id: GO:0021878
name: forebrain astrocyte fate commitment
namespace: biological_process
def:
  "The process in which the developmental fate of a cell becomes restricted such that it will develop into an astrocyte that resides in the forebrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:16226447]


id: GO:0021879
name: forebrain neuron differentiation
namespace: biological_process
def:
  "The process in which a relatively unspecialized cell acquires specialized features of a neuron that will reside in the forebrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:16226447]


id: GO:0021880
name: Notch signaling pathway involved in forebrain neuron fate commitment
namespace: biological_process
def:
  "The series of molecular signals initiated by binding of an extracellular ligand to a Notch receptor on the surface of the target cell that contributes to the commitment of a neuroblast to a neuronal fate. The neuron will reside in the forebrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:16226447]


id: GO:0021881
name: Wnt-activated signaling pathway involved in forebrain neuron fate commitment
namespace: biological_process
def:
  "The series of molecular signals initiated by binding of Wnt protein to a receptor on the surface of the target cell that contributes to the commitment of a neuroblast to aneuronal fate. The neuron will reside in the forebrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:16226447]


id: GO:0021882
namespace: biological_process
name:
  regulation of transcription from RNA polymerase II promoter involved in forebrain neuron fate commitment

def:
  "Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter that contributes to the commitment of a neuroblast to a neuronal fate. The neuron will reside in the forebrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:16226447]


id: GO:0021883
name: cell cycle arrest of committed forebrain neuronal progenitor cell
namespace: biological_process
def:
  "The process in which the cell cycle is halted during one of the normal phases (G1, S, G2, M) in a cell that has been committed to become a neuron that will reside in the forebrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, GOC:tb, PMID:16226447]


id: GO:0021884
name: forebrain neuron development
namespace: biological_process
def:
  "The process whose specific outcome is the progression of a neuron that resides in the forebrain, from its initial commitment to its fate, to the fully functional differentiated cell." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]


id: GO:0021885
name: forebrain cell migration
namespace: biological_process
def:
  "The orderly movement of a cell from one site to another at least one of which is located in the forebrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]


id: GO:0021886
name: hypothalamus gonadotrophin-releasing hormone neuron differentiation
namespace: biological_process
def:
  "The process in which a relatively unspecialized cell acquires specialized features of a neuron located in the hypothalamus. These neurons release gonadotrophin-releasing hormone as a neural transmitter." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695]


id: GO:0021887
name: hypothalamus gonadotrophin-releasing hormone neuron fate commitment
namespace: biological_process
def:
  "The process in which the developmental fate of a cell becomes restricted such that it will develop into a hypothalamus neuron that releases gonadotrophin-releasing hormone." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695]


id: GO:0021888
name: hypothalamus gonadotrophin-releasing hormone neuron development
namespace: biological_process
def:
  "The process whose specific outcome is the progression of a hypothalamus gonadotrophin-releasing hormone neuron over time, from initial commitment of its fate, to the fully functional differentiated cell." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695]


id: GO:0021889
name: olfactory bulb interneuron differentiation
namespace: biological_process
def:
  "The process in which a neuroblast acquires specialized features of an interneuron residing in the olfactory bulb." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695]


id: GO:0021890
name: olfactory bulb interneuron fate commitment
namespace: biological_process
def:
  "The process in which the developmental fate of a neuroblast becomes restricted such that it will develop into an interneuron residing in the olfactory bulb." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695]


id: GO:0021891
name: olfactory bulb interneuron development
namespace: biological_process
def:
  "The process whose specific outcome is the progression of an interneuron residing in the olfactory bulb, from its initial commitment, to the fully functional differentiated cell." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695]


id: GO:0021892
name: cerebral cortex GABAergic interneuron differentiation
namespace: biological_process
def:
  "The process in which a relatively unspecialized cell acquires specialized features of a GABAergic interneuron residing in the cerebral cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695]


id: GO:0021893
name: cerebral cortex GABAergic interneuron fate commitment
namespace: biological_process
def:
  "The process in which the developmental fate of a neuroblast becomes restricted such that it will develop into a GABAergic interneuron residing in the cerebral cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695]


id: GO:0021894
name: cerebral cortex GABAergic interneuron development
namespace: biological_process
def:
  "The process whose specific outcome is the progression of a cerebral cortex GABAergic interneuron over time, from initial commitment to its fate, to the fully functional differentiated cell." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695]


id: GO:0021895
name: cerebral cortex neuron differentiation
namespace: biological_process
def:
  "The process in which a relatively unspecialized cell acquires specialized features of a neuron residing in the cerebral cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]


id: GO:0021896
name: forebrain astrocyte differentiation
namespace: biological_process
def:
  "The process in which a relatively unspecialized cell acquires the specialized features of an astrocyte residing in the forebrain. An astrocyte is the most abundant type of glial cell. Astrocytes provide support for neurons and regulate the environment in which they function." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:16226447]


id: GO:0021897
name: forebrain astrocyte development
namespace: biological_process
def:
  "The process aimed at the progression of an astrocyte that resides in the forebrain, from initial commitment of the cell to its fate, to the fully functional differentiated cell. An astrocyte is the most abundant type of glial cell. Astrocytes provide support for neurons and regulate the environment in which they function." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]


id: GO:0021898
name: commitment of multipotent stem cells to neuronal lineage in forebrain
namespace: biological_process
def:
  "The initial commitment of cells whereby the developmental fate of a cell becomes restricted such that it will develop into some type of neuron in the forebrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695]


id: GO:0021899
name: fibroblast growth factor receptor signaling pathway involved in forebrain neuron fate commitment
namespace: biological_process
def:
  "The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands that contributes to the commitment of a neuroblast to a neuronal fate. The neuron will reside in the forebrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:16226447]


id: GO:0021900
name: ventricular zone cell fate commitment
namespace: biological_process
def:
  "The commitment of neuroblast to become a basal progenitor cell. Basal progenitor cells are neuronal precursor cells that are committed to becoming neurons." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:16226447]


id: GO:0021901
name: early neuron fate commitment in forebrain
namespace: biological_process
def:
  "The commitment of neuroepithelial cell to become a neuron that will reside in the forebrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:16226447]


id: GO:0021902
name: commitment of neuronal cell to specific neuron type in forebrain
namespace: biological_process
def:
  "The commitment of neuronal precursor cells to become specialized types of neurons in the forebrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:16226447]


id: GO:0021903
name: rostrocaudal neural tube patterning
namespace: biological_process
def:
  "The process in which the neural tube is divided into specific regions along the rostrocaudal axis." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:11262869]


id: GO:0021904
name: dorsal/ventral neural tube patterning
namespace: biological_process
def:
  "The process in which the neural tube is regionalized in the dorsoventral axis." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:11262869]


id: GO:0021905
name: forebrain-midbrain boundary formation
namespace: biological_process
def:
  "The process whose specific outcome is the creation of the forebrain-midbrain boundary." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:11262869]


id: GO:0021906
name: hindbrain-spinal cord boundary formation
namespace: biological_process
def:
  "The process whose specific outcome is the formation of the hindbrain-spinal cord boundary." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:11262869]


id: GO:0021907
namespace: biological_process
name:
  fibroblast growth factor receptor signaling pathway involved in spinal cord anterior/posterior pattern formation

def:
  "The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands that results in the spatial identity of regions along the anterior-posterior axis of the spinal cord." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:11262869]


id: GO:0021908
namespace: biological_process
name:
  retinoic acid receptor signaling pathway involved in spinal cord anterior/posterior pattern formation

def:
  "The series of molecular signals generated as a consequence of a retinoic acid receptor binding to one of its physiological ligands that results in the spatial identity of regions along the anterior-posterior axis of the spinal cord." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:11262869]


id: GO:0021909
namespace: biological_process
name:
  regulation of transcription from RNA polymerase II promoter involved in spinal cord anterior-posterior patterning

def:
  "Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter that results in the spatial identity of regions along the anterior-posterior axis of the spinal cord." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:11262869]


id: GO:0021910
name: smoothened signaling pathway involved in ventral spinal cord patterning
namespace: biological_process
def:
  "The series of molecular signals generated as a consequence of activation of the transmembrane protein Smoothened that results in the spatial identity of regions along the dorsal-ventral axis of the spinal cord." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, GOC:tb, PMID:11262869]


id: GO:0021911
name: retinoic acid metabolic process in spinal cord anterior-posterior patterning
namespace: biological_process
def:
  "The chemical reactions and pathways involving the synthesis and degradation of retionic acid that results in the spatial identity of regions along the anterior-posterior axis of the spinal cord." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:11262869]


id: GO:0021912
namespace: biological_process
name:
  regulation of transcription from RNA polymerase II promoter involved in spinal cord motor neuron fate specification

def:
  "Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter that results the commitment of a cell to become a motor neuron in the ventral spinal cord." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:11262869]


id: GO:0021913
namespace: biological_process
name:
  regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification

def:
  "Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter that results in the commitment of a cell to become an interneuron in the ventral spinal cord." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:11262869]


id: GO:0021914
name: negative regulation of smoothened signaling pathway involved in ventral spinal cord patterning
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of smoothened signaling that is involved in the patterns of cell differentiation in the ventral spinal cord." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, GOC:tb, PMID:11262869]


id: GO:0021915
name: neural tube development
namespace: biological_process
def:
  "The process whose specific outcome is the progression of the neural tube over time, from its formation to the mature structure. The mature structure of the neural tube exists when the tube has been segmented into the forebrain, midbrain, hindbrain and spinal cord regions. In addition neural crest has budded away from the epithelium." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]


id: GO:0021916
name: inductive cell-cell signaling between paraxial mesoderm and motor neuron precursors
namespace: biological_process
def:
  "Short range signaling between cells of the paraxial mesoderm and motor neuron precursors in the spinal cord that specifies the fate of the motor column neuron precursors along the anterior-posterior axis." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:11262869]


id: GO:0021917
name: somatic motor neuron fate commitment
namespace: biological_process
def:
  "The commitment of unspecified motor neurons to specific motor neuron cell along the anterior-posterior axis of the spinal cord and their capacity to differentiate into specific motor neurons." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]


id: GO:0021918
namespace: biological_process
name:
  regulation of transcription from RNA polymerase II promoter involved in somatic motor neuron fate commitment

def:
  "Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter that contributes to the commitment of spinal cord motor neurons to specific motor neuron types along the anterior-posterior axis." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:11262869]


id: GO:0021919
name: BMP signaling pathway involved in spinal cord dorsal/ventral patterning
namespace: biological_process
def:
  "A series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, which contributes to the spatial identity of regions along the dorsal-ventral axis of the spinal cord." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12593981]


id: GO:0021920
namespace: biological_process
name:
  regulation of transcription from RNA polymerase II promoter involved in spinal cord association neuron specification

def:
  "Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter that contributes to the commitment of neuronal precursors to association neurons in the dorsal spinal cord." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12593981]


id: GO:0021921
name: regulation of cell proliferation in dorsal spinal cord
namespace: biological_process
def:
  "The process that modulates the frequency, rate or extent of cell proliferation in the dorsal spinal cord." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]


id: GO:0021922
name: Wnt signaling pathway involved in regulation of cell proliferation in dorsal spinal cord
namespace: biological_process
def:
  "The series of molecular signals initiated by binding of Wnt protein to a receptor on the surface of a cell in the dorsal spinal cord that affects the rate of its division." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12593981]


id: GO:0021923
name: cell proliferation in hindbrain ventricular zone
namespace: biological_process
def:
  "The multiplication or reproduction of cells, resulting in the expansion of a cell population in the hindbrain region that is adjacent to the ventricular cavity." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12593981, PMID:15157725]


id: GO:0021924
name: cell proliferation in external granule layer
namespace: biological_process
def:
  "The multiplication or reproduction of neuroblasts resulting in the expansion of a cell population in the external granule layer of the hindbrain. The external granule layer is the layer that originates from the rostral half of the rhombic lip in the first rhombomere." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:15157725]


id: GO:0021925
name: cerebellar Purkinje cell precursor proliferation
namespace: biological_process
def:
  "The multiplication or reproduction of neuroblasts that will give rise to Purkinje cells. A Purkinje cell is an inhibitory GABAergic neuron found in the cerebellar cortex that projects to the deep cerebellar nuclei and brain stem." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:15157725]


id: GO:0021926
name: Golgi cell precursor proliferation
namespace: biological_process
def:
  "The multiplication or reproduction of neuroblasts that will give rise to Golgi cells. A Golgi cell is an inhibitory GABAergic interneuron found in the cerebellar cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:15157725]


id: GO:0021927
name: deep nuclear neuron precursor proliferation
namespace: biological_process
def:
  "The multiplication or reproduction of neuroblasts that will give rise to deep nuclear neurons." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:15157725]


id: GO:0021928
name: basket cell precursor proliferation
namespace: biological_process
def:
  "The multiplication or reproduction of neuroblasts that will give rise to basket cells. A cerebellar basket cell is an inhibitory GABAergic interneuron found in the cerebellar cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:15157725]


id: GO:0021929
name: stellate cell precursor proliferation
namespace: biological_process
def:
  "The multiplication or reproduction of neuroblasts that will give rise to stellate cells. A cerebellar stellate cell is an inhibitory GABAergic interneuron found in the cerebellar cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:15157725]


id: GO:0021930
name: cerebellar granule cell precursor proliferation
namespace: biological_process
def:
  "The multiplication or reproduction of neuroblasts that will give rise to granule cells. A granule cell is a glutamatergic interneuron found in the cerebellar cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:15157725]


id: GO:0021931
name: rostral hindbrain neuronal precursor cell proliferation
namespace: biological_process
def:
  "The multiplication or reproduction of neuroblasts that will give rise to neurons of the lateral pontine nucleus and the locus ceruleus." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:15157725]


id: GO:0021932
name: hindbrain radial glia guided cell migration
namespace: biological_process
def:
  "The radially directed movement of a cell along radial glial cells in the hindbrain. Radial migration refers to a directed movement from the internal ventricular area to the outer surface of the hindbrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:15157725]


id: GO:0021933
name: radial glia guided migration of cerebellar granule cell
namespace: biological_process
def:
  "The inward migration of postmitotic granule cells along a radial glial cell from the external granule layer to the internal granule cell layer." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:15157725]


id: GO:0021934
name: hindbrain tangential cell migration
namespace: biological_process
def:
  "The migration of a cell in the hindbrain in which cells move orthogonal to the direction of radial migration." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]


id: GO:0021935
name: cerebellar granule cell precursor tangential migration
namespace: biological_process
def:
  "The early migration of granule cell precursors in which cells move orthogonal to the direction of radial migration and ultimately cover the superficial zone of the cerebellar primordium." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:15157725]


id: GO:0021936
name: regulation of cerebellar granule cell precursor proliferation
namespace: biological_process
def:
  "The process that modulates the frequency, rate or extent of granule cell precursor proliferation." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:15157725]


id: GO:0021937
namespace: biological_process
name:
  cerebellar Purkinje cell-granule cell precursor cell signaling involved in regulation of granule cell precursor cell proliferation

def:
  "The process that mediates the transfer of information from Purkinje cells to granule cell precursors resulting in an increase in rate of granule cell precursor cell proliferation." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:15157725]


id: GO:0021938
namespace: biological_process
name:
  smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation

def:
  "The series of molecular signals generated as a consequence of activation of the transmembrane protein Smoothened in cerebellar granule cells that contributes to the regulation of proliferation of the cells." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, GOC:tb, PMID:15157725]


id: GO:0021939
namespace: biological_process
name:
  extracellular matrix-granule cell signaling involved in regulation of granule cell precursor proliferation

def:
  "The process that mediates the transfer of information from the extracellular matrix to granule cell precursors resulting in a decrease in rate of granule cell precursor cell proliferation." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:15157725]


id: GO:0021940
name: positive regulation of cerebellar granule cell precursor proliferation
namespace: biological_process
def:
  "The process that activates or increases the rate or extent of granule cell precursor proliferation." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:15157725]


id: GO:0021941
name: negative regulation of cerebellar granule cell precursor proliferation
namespace: biological_process
def:
  "The process that stops, prevents or reduces the rate or extent of granule cell precursor proliferation." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:15157725]


id: GO:0021942
name: radial glia guided migration of Purkinje cell
namespace: biological_process
def:
  "The migration of postmitotic a Purkinje cell along radial glial cells from the ventricular zone to the Purkinje cell layer." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:15157725]


id: GO:0021943
name: formation of radial glial scaffolds
namespace: biological_process
def:
  "The formation of scaffolds from a radial glial cell. The scaffolds are used as a substrate for the radial migration of cells." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:15157725]


id: GO:0021944
name: neuronal-glial interaction involved in hindbrain glial-mediated radial cell migration
namespace: biological_process
def:
  "The changes in adhesion between a neuronal cell and a glial cell as a component of the process of hindbrain glial-mediated radial cell migration." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:15157725]


id: GO:0021945
name: positive regulation of cerebellar granule cell migration by calcium
namespace: biological_process
def:
  "The process that increases the extent of granule cell motility using intracellular calcium signaling mechanisms during radial migration." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, GOC:tb, PMID:15157725]


id: GO:0021946
name: deep nuclear neuron cell migration
namespace: biological_process
def:
  "The directed movement of a deep nuclear neuron from the ventricular zone to the deep hindbrain nuclei." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:15157725]


id: GO:0021947
name: outward migration of deep nuclear neurons
namespace: biological_process
def:
  "The directed movement of a deep nuclear neuron from their ventrolateral origin to a rostrodorsal region of the cerebellar plate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:15157725]


id: GO:0021948
name: inward migration of deep nuclear neurons
namespace: biological_process
def:
  "The directed movement of a deep nuclear neuron from the rostrodorsal region of the cerebellar plate to their final more ventral position." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:15157725]


id: GO:0021949
name: brainstem precerebellar neuron precursor migration
namespace: biological_process
def:
  "The early migration of a precerebellar neuronal precursor in which a cell move from the rhombic lip, orthogonal to the direction of radial migration and ultimately reside in the brainstem." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:15157725]


id: GO:0021950
name: chemorepulsion involved in precerebellar neuron migration
namespace: biological_process
def:
  "The creation and reception of signals that repel a precerebellar neuron as a component of the process of tangential migration." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:15157725]


id: GO:0021951
name: chemoattraction involved in precerebellar neuron migration
namespace: biological_process
def:
  "The creation and reception of signals that guide a precerebellar neuron towards their signals, where this process is involved in tangential migration." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:15157725]


id: GO:0021952
name: central nervous system projection neuron axonogenesis
namespace: biological_process
def:
  "Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body towards target cells in a different central nervous system region." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]


id: GO:0021953
name: central nervous system neuron differentiation
namespace: biological_process
def:
  "The process in which a relatively unspecialized cell acquires specialized features of a neuron whose cell body resides in the central nervous system." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]


id: GO:0021954
name: central nervous system neuron development
namespace: biological_process
def:
  "The process whose specific outcome is the progression of a neuron whose cell body is located in the central nervous system, from initial commitment of the cell to a neuronal fate, to the fully functional differentiated neuron." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]


id: GO:0021955
name: central nervous system neuron axonogenesis
namespace: biological_process
def:
  "Generation of a long process from a neuron whose cell body resides in the central nervous system. The process carries efferent (outgoing) action potentials from the cell body towards target cells." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]


id: GO:0021956
name: central nervous system interneuron axonogenesis
namespace: biological_process
def:
  "Generation of a long process that carries efferent (outgoing) action potentials from the cell body towards target cells from a neuron located in the central nervous system whose axons remain within a single brain region." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]


id: GO:0021957
name: corticospinal tract morphogenesis
namespace: biological_process
def:
  "Generation of a long process of a pyramidal cell, that carries efferent (outgoing) action potentials from the cell body in cerebral cortex layer V towards target cells in the gray matter of the spinal cord. This axonal process is a member of those that make up the corticospinal tract." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:9878731]


id: GO:0021958
name: gracilis tract morphogenesis
namespace: biological_process
def:
  "Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body in the dorsal root ganglion towards target cells in the medulla. This axonal process is a member of those that make up the gracilis tract, a group of axons that are from neurons involved in proprioception from the lower trunk and lower limb." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12867698]


id: GO:0021959
name: cuneatus tract morphogenesis
namespace: biological_process
def:
  "Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body in the dorsal root ganglion towards target cells in the medulla. This axonal process is a member of those that make up the cuneatus tract, a group of axons that are from neurons involved in proprioception from the upper trunk and upper limb." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12867698]


id: GO:0021960
name: anterior commissure morphogenesis
namespace: biological_process
def:
  "Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body in one half of the cerebral cortex towards target cells in the contralateral half. This axonal process is a member of those that make up the anterior commissure, a small midline fiber tract that lies at the anterior end of the corpus callosum." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0878937420]


id: GO:0021961
name: posterior commissure morphogenesis
namespace: biological_process
def:
  "Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body in the midbrain towards target cells in the diencephalon." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]


id: GO:0021962
name: vestibulospinal tract morphogenesis
namespace: biological_process
def:
  "Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body in the vestibular nucleus of the pons towards target cells in the spinal cord." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]


id: GO:0021963
name: spinothalamic tract morphogenesis
namespace: biological_process
def:
  "Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body in the spinal cord towards target cells in the thalamus. This axonal process is a member of those that make up the spinothalamic tract, one of the major routes of nociceptive signaling." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]


id: GO:0021964
name: rubrospinal tract morphogenesis
namespace: biological_process
def:
  "Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body in the red nucleus of the midbrain towards target cells in the spinal cord." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]


id: GO:0021965
name: spinal cord ventral commissure morphogenesis
namespace: biological_process
def:
  "The process in which the anatomical structures of the spinal cord ventral commissure are generated and organized." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]


id: GO:0021966
name: corticospinal neuron axon guidance
namespace: biological_process
def:
  "The process in which the migration of an axon growth cone of a neuron that is part of the corticospinal tract is directed from the cerebral cortex layer V to the spinal cord dorsal funiculus in response to a combination of attractive and repulsive cues." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:9878731]


id: GO:0021967
name: corticospinal neuron axon guidance through the cerebral cortex
namespace: biological_process
def:
  "The process in which the migration of an axon growth cone of a pyramidal cell that is part of the corticospinal tract is directed from its cell body in layer V through the cerebral cortex in response to a combination of attractive and repulsive cues." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:9878731]


id: GO:0021968
name: corticospinal neuron axon guidance through the internal capsule
namespace: biological_process
def:
  "The process in which the migration of an axon growth cone of a pyramidal cell that is part of the corticospinal tract is directed after exiting the cerebral cortex through the internal capsule in response to a combination of attractive and repulsive cues." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:9878731]


id: GO:0021969
name: corticospinal neuron axon guidance through the cerebral peduncle
namespace: biological_process
def:
  "The process in which the migration of an axon growth cone of a pyramidal cell that is part of the corticospinal tract is directed after exiting the internal capsule through the cerebral peduncle in response to a combination of attractive and repulsive cues." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:9878731]


id: GO:0021970
name: corticospinal neuron axon guidance through the basilar pons
namespace: biological_process
def:
  "The process in which the migration of an axon growth cone of a pyramidal cell that is part of the corticospinal tract is directed after exiting the cerebral peduncle through the basilar pons in response to a combination of attractive and repulsive cues." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:9878731]


id: GO:0021971
name: corticospinal neuron axon guidance through the medullary pyramid
namespace: biological_process
def:
  "The process in which the migration of an axon growth cone of a pyramidal cell that is part of the corticospinal tract is directed after exiting the basilar pons through the medullary pyramid in response to a combination of attractive and repulsive cues." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:9878731]


id: GO:0021972
name: corticospinal neuron axon guidance through spinal cord
namespace: biological_process
def:
  "The process in which the migration of an axon growth cone of a pyramidal cell that is part of the corticospinal tract is directed after decussation through the spinal cord in response to a combination of attractive and repulsive cues." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:9878731]


id: GO:0021973
name: corticospinal neuron axon decussation
namespace: biological_process
def:
  "The process in which the migration of an axon growth cone of a pyramidal cell that is part of the corticospinal tract is directed to cross the midline to the contralateral side." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:9878731]


id: GO:0021974
name: trigeminothalamic tract morphogenesis
namespace: biological_process
def:
  "Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body in spinal cord towards target cells in the thalamus. This axonal process is a member of those that make up the trigeminothalamic tract, one of the major routes of nociceptive and temperature signaling from the face." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0878937420]


id: GO:0021975
name: pons reticulospinal tract morphogenesis
namespace: biological_process
def:
  "Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body in the pons towards target cells in the spinal cord." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]


id: GO:0021976
name: medulla reticulospinal tract morphogenesis
namespace: biological_process
def:
  "Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body in the medulla towards target cells in the spinal cord." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]


id: GO:0021977
name: tectospinal tract morphogenesis
namespace: biological_process
def:
  "Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body in the superior colliculus of the midbrain towards target cells in the ventral spinal cord." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]


id: GO:0021978
name: telencephalon regionalization
namespace: biological_process
def:
  "The regionalization process that creates areas within the forebrain that will direct the behavior of cell migration in differentiation as the telencephalon develops." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mgi_curators, GOC:mtg_15jun06]


id: GO:0021979
name: hypothalamus cell differentiation
namespace: biological_process
def:
  "The differentiation of cells that will contribute to the structure and function of the hypothalamus." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mgi_curators, GOC:mtg_15jun06]


id: GO:0021980
name: subpallium cell migration
namespace: biological_process
def:
  "The orderly movement of cells from one site to another in the subpallium." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]


id: GO:0021981
name: subpallium radially oriented migration
namespace: biological_process
def:
  "The migration of cells in the developing subpallium in which cells move from the ventricular and/or subventricular zone toward the surface of the brain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]


id: GO:0021982
name: pineal gland development
namespace: biological_process
def:
  "The progression of the pineal gland over time from its initial formation until its mature state. The pineal gland is an endocrine gland that secretes melatonin and is involved in circadian rhythms." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]


id: GO:0021983
name: pituitary gland development
namespace: biological_process
def:
  "The progression of the pituitary gland over time from its initial formation until its mature state. The pituitary gland is an endocrine gland that secretes hormones that regulate many other glands." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]


id: GO:0021984
name: adenohypophysis development
namespace: biological_process
def:
  "The progression of the adenohypophysis over time from its initial formation until its mature state. The adenohypophysis is the anterior part of the pituitary. It secretes a variety of hormones and its function is regulated by the hypothalamus." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]


id: GO:0021985
name: neurohypophysis development
namespace: biological_process
def:
  "The progression of the neurohypophysis over time from its initial formation until its mature state. The neurohypophysis is the part of the pituitary gland that secretes hormones involved in blood pressure regulation." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]


id: GO:0021986
name: habenula development
namespace: biological_process
def:
  "The progression of the habenula over time from its initial formation until its mature state. The habenula is the group of nuclei that makes up the stalk of the pineal gland." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:9780721601465]


id: GO:0021987
name: cerebral cortex development
namespace: biological_process
def:
  "The progression of the cerebral cortex over time from its initial formation until its mature state. The cerebral cortex is the outer layered region of the telencephalon." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]


id: GO:0021988
name: olfactory lobe development
namespace: biological_process
def:
  "The progression of the olfactory lobe over time from its initial formation until its mature state. The olfactory lobe is the area of the brain that process the neural inputs for the sense of smell." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]


id: GO:0021989
name: olfactory cortex development
namespace: biological_process
def:
  "The progression of the olfactory cortex over time from its initial formation until its mature state. The olfactory cortex is involved in the perception of smell. It receives input from the olfactory bulb and is responsible for the identification of odors." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]


id: GO:0021990
name: neural plate formation
namespace: biological_process
def:
  "The formation of the flat, thickened layer of ectodermal cells known as the neural plate. The underlying dorsal mesoderm signals the ectodermal cells above it to elongate into columnar neural plate cells. The neural plate subsequently develops into the neural tube, which gives rise to the central nervous system." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0878932437, ISBN:0878932585, PMID:15806586]


id: GO:0021991
name: neural plate thickening
namespace: biological_process
def:
  "The process of apical-basal elongation of individual ectodermal cells during the formation of the neural placode." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:15806586]


id: GO:0021992
name: cell proliferation involved in neural plate elongation
namespace: biological_process
def:
  "The process of expansion of cell numbers in the neural plate due to cell division of progenitor cells preferentially in the rostrocaudal direction, resulting in the elongation of the tissue." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:15806586]


id: GO:0021993
name: initiation of neural tube closure
namespace: biological_process
def:
  "The process in which closure points are established at multiple points and along the neural rostrocaudal axis." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]


id: GO:0021994
name: progression of neural tube closure
namespace: biological_process
def:
  "The process in which the neural folds are fused extending from the initial closure points." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]


id: GO:0021995
name: neuropore closure
namespace: biological_process
def:
  "The process of joining together the neural folds at either end of the neural tube." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]


id: GO:0021996
name: lamina terminalis formation
namespace: biological_process
def:
  "The process in which the anterior-most portion of the neural axis is formed by closure of the anterior neuropore." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]


id: GO:0021997
name: neural plate axis specification
namespace: biological_process
def:
  "The pattern specification process in which the axes of the nervous system are established." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]


id: GO:0021998
name: neural plate mediolateral regionalization
namespace: biological_process
def:
  "The process that regulates the coordinated growth and differentiation that establishes the non-random mediolateral spatial arrangement of the neural plate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]


id: GO:0021999
name: neural plate anterior/posterior regionalization
namespace: biological_process
def:
  "The process that regulates the coordinated growth and differentiation that establishes the non-random anterior-posterior spatial arrangement of the neural plate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]


id: GO:0022000
name: forebrain induction by the anterior neural ridge
namespace: biological_process
def:
  "The close range interaction of the anterior neural ridge to the caudal region of the neural plate that specifies the forebrain fate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]


id: GO:0022001
name: negative regulation of anterior neural cell fate commitment of the neural plate
namespace: biological_process
def:
  "Any process that stops, prevents or reduces the frequency or rate at which a cell adopts an anterior neural cell fate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, GOC:tb]


id: GO:0022002
namespace: biological_process
name:
  negative regulation of anterior neural cell fate commitment of the neural plate by Wnt signaling pathway

def:
  "The series of molecular signals that stops, prevents or reduces the frequency or rate at which a cell adopts an anterior neural cell fate, initiated by binding of Wnt protein to a receptor on the surface of the target cell." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, GOC:tb]


id: GO:0022003
namespace: biological_process
name:
  negative regulation of anterior neural cell fate commitment of the neural plate by fibroblast growth factor receptor signaling pathway

def:
  "The series of molecular signals that stops, prevents or reduces the frequency or rate at which cell adopts an anterior neural cell fate, generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, GOC:tb]


id: GO:0022004
name: midbrain-hindbrain boundary maturation during brain development
namespace: biological_process
def:
  "A developmental process occurring after the brain has been specified along the neural axis that is required for the midbrain-hindbrain boundary to attain its fully functional state. The midbrain-hindbrain domain of the embryonic brain is comprised of the mesencephalic vesicle and the first rhombencephalic vesicle at early somitogenesis stages. An organizing center at the boundary patterns the midbrain and hindbrain primordia of the neural plate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:15541513]


id: GO:0022005
name: midbrain-hindbrain boundary maturation during neural plate development
namespace: biological_process
def:
  "A developmental process occurring before the brain has been specified along the neural axis that is required for the midbrain-hindbrain boundary to attain its fully functional state. The midbrain-hindbrain domain of the embryonic brain is comprised of the mesencephalic vesicle and the first rhombencephalic vesicle at early somitogenesis stages. An organizing center at the boundary patterns the midbrain and hindbrain primordia of the neural plate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:15541513]


id: GO:0022006
name: zona limitans intrathalamica formation
namespace: biological_process
def:
  "The formation of the narrow stripe of cells that lies between the prospective dorsal and ventral thalami. This boundary contains signals that pattern the prethalamic and thalamic territories of the future mid-diencephalon." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:11425897, PMID:16452095]


id: GO:0022007
name: convergent extension involved in neural plate elongation
namespace: biological_process
def:
  "The process of directed cell movement in the neural plate resulting in tissue elongation via intercalation of adjacent cells in an epithelial sheet at the midline, leading to narrowing and lengthening of the neural plate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:13679871, PMID:15806586]


id: GO:0022008
name: neurogenesis
namespace: biological_process
def:
  "Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]


id: GO:0022009
name: central nervous system vasculogenesis
namespace: biological_process
def:
  "The differentiation of endothelial cells from progenitor cells during blood vessel development, and the de novo formation of blood vessels and tubes in the central nervous system. The capillary endothelial cells in the brain are specialized to form the blood-brain barrier." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]


id: GO:0022010
name: central nervous system myelination
namespace: biological_process
def:
  "The process in which neuronal axons and dendrites become coated with a segmented lipid-rich sheath (myelin) to enable faster and more energetically efficient conduction of electrical impulses. The sheath is formed by the cell membranes of oligodendrocytes in the central nervous system. Adjacent myelin segments are separated by a non-myelinated stretch of axon called a node of Ranvier." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]


id: GO:0022011
name: myelination in peripheral nervous system
namespace: biological_process
def:
  "The process in which neuronal axons and dendrites become coated with a segmented lipid-rich sheath (myelin) to enable faster and more energetically efficient conduction of electrical impulses. The sheath is formed by the cell membranes of Schwann cells in the peripheral nervous system. Adjacent myelin segments are separated by a non-myelinated stretch of axon called a node of Ranvier." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]


id: GO:0022012
name: subpallium cell proliferation in forebrain
namespace: biological_process
def:
  "The multiplication or reproduction of subpallium cells in the forebrain, resulting in the expansion of a cell population." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]


id: GO:0022013
name: pallium cell proliferation in forebrain
namespace: biological_process
def:
  "The multiplication or reproduction of pallium cells in the forebrain, resulting in the expansion of the cell population." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]


id: GO:0022014
name: radial glial cell division in subpallium
namespace: biological_process
def:
  "The division of a radial glial cell in the subpallium. A radial glial cell is a precursor cell that gives rise to neurons and astrocytes." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]


id: GO:0022015
name: radial glial cell division in pallium
namespace: biological_process
def:
  "The division of a radial glial cell in the pallium. A radial glial cell is a precursor cell that gives rise to neurons and astrocytes." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]


id: GO:0022016
name: pallium glioblast division
namespace: biological_process
def:
  "The division of a glioblast in the pallium. A glioblast is a dividing precursor cell that gives rise to glial cells." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]


id: GO:0022017
name: neuroblast division in pallium
namespace: biological_process
def:
  "The division of neuroblasts in the pallium. Neuroblasts are precursor cells that give rise to neurons." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]


id: GO:0022018
name: lateral ganglionic eminence cell proliferation
namespace: biological_process
def:
  "The multiplication or reproduction of lateral ganglionic eminence cells, resulting in the expansion of the cell population." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]


id: GO:0022019
name: dorsal lateral ganglionic eminence cell proliferation
namespace: biological_process
def:
  "The multiplication or reproduction of dorsal lateral ganglionic eminence cells, resulting in the expansion of the cell population." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]


id: GO:0022020
name: medial ganglionic eminence cell proliferation
namespace: biological_process
def:
  "The multiplication or reproduction of medial ganglionic eminence cells, resulting in the expansion of a cell population." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]


id: GO:0022021
name: caudal ganglionic eminence cell proliferation
namespace: biological_process
def:
  "The multiplication or reproduction of caudal ganglionic eminence cells, resulting in the expansion of a cell population." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]


id: GO:0022022
name: septal cell proliferation
namespace: biological_process
def:
  "The multiplication or reproduction of septal cells, resulting in the expansion of a cell population." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]


id: GO:0022023
name: radial glial cell fate commitment in forebrain
namespace: biological_process
def:
  "The process in which the developmental fate of a cell becomes restricted such that it will develop into a radial glial cell in the forebrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]


id: GO:0022024
name: BMP signaling pathway involved in forebrain neuron fate commitment
namespace: biological_process
def:
  "A series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, which contributes to the commitment of a neuroblast to a neuronal fate. The neuron will reside in the forebrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]


id: GO:0022025
name: leukemia inhibitory factor signaling pathway involved in forebrain neuron fate commitment
namespace: biological_process
def:
  "Any series of molecular signals initiated by the binding of leukemia inhibitory factor to a receptor on the surface of the target cell, that contributes to the commitment of a neuroblast to a neuronal fate. The neuron will reside in the forebrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, GOC:signaling]


id: GO:0022026
name: epidermal growth factor signaling pathway involved in forebrain neuron fate commitment
namespace: biological_process
def:
  "The series of molecular signals generated as a consequence of a epidermal growth factor receptor binding to one of its physiological ligands that contributes to the commitment of a neuroblast to a neuronal fate. The neuron will reside in the forebrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]


id: GO:0022027
name: interkinetic nuclear migration
namespace: biological_process
def:
  "The movement of the nucleus of the ventricular zone cell between the apical and the basal zone surfaces. Mitosis occurs when the nucleus is near the apical surface, that is, the lumen of the ventricle." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]


id: GO:0022028
name: tangential migration from the subventricular zone to the olfactory bulb
namespace: biological_process
def:
  "The migration of cells in the telencephalon from the subventricular zone to the olfactory bulb in which cells move orthogonally to the direction of radial migration and do not use radial glial cell processes as substrates for migration." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]


id: GO:0022029
name: telencephalon cell migration
namespace: biological_process
def:
  "The orderly movement of a cell from one site to another at least one of which is located in the telencephalon." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]


id: GO:0022030
name: telencephalon glial cell migration
namespace: biological_process
def:
  "The orderly movement of glial cells through the telencephalon." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]


id: GO:0022031
name: telencephalon astrocyte cell migration
namespace: biological_process
def:
  "The orderly movement of an astrocyte cell through the telencephalon." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]


id: GO:0022032
name: telencephalon oligodendrocyte cell migration
namespace: biological_process
def:
  "The multiplication or reproduction of telencephalon oligodendrocyte cells, resulting in the expansion of a cell population." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]


id: GO:0022033
name: telencephalon microglial cell migration
namespace: biological_process
def:
  "The orderly movement of microglial cells through the telencephalon." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]


id: GO:0022034
name: rhombomere cell proliferation
namespace: biological_process
def:
  "The multiplication or reproduction of rhombomere cells, resulting in the expansion of the cell population." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]


id: GO:0022035
name: rhombomere cell migration
namespace: biological_process
def:
  "The movement of a cell within a rhombomere. This process is known to occur as an early step in the generation of anatomical structure from a rhombomere." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:15629700]


id: GO:0022036
name: rhombomere cell differentiation
namespace: biological_process
def:
  "The process in which a relatively unspecialized cell acquires specialized features of a rhombomere cell." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]


id: GO:0022037
name: metencephalon development
namespace: biological_process
def:
  "The process whose specific outcome is the progression of the metencephalon over time, from its formation to the mature structure." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]


id: GO:0022038
name: corpus callosum development
namespace: biological_process
def:
  "The process whose specific outcome is the progression of the corpus callosum over time, from its formation to the mature structure. The corpus callosum is a thick bundle of nerve fibers comprising a commissural plate connecting the two cerebral hemispheres. It consists of contralateral axon projections that provide communication between the right and left cerebral hemispheres." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06]


id: GO:0022400
name: regulation of rhodopsin mediated signaling pathway
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of rhodopsin-mediated signaling." [GOC:mah]


id: GO:0022401
name: negative adaptation of signaling pathway
namespace: biological_process
def:
  "The negative regulation of a signal transduction pathway in response to a stimulus upon prolonged exposure to that stimulus." [GOC:isa_complete]


id: GO:0022402
name: cell cycle process
namespace: biological_process
def:
  "The cellular process that ensures successive accurate and complete genome replication and chromosome segregation." [GOC:isa_complete, GOC:mtg_cell_cycle]


id: GO:0022403
name: cell cycle phase
namespace: biological_process
def:
  "One of the distinct periods or stages into which the cell cycle is divided. Each phase is characterized by the occurrence of specific biochemical and morphological events." [GOC:mtg_cell_cycle]


id: GO:0022404
name: molting cycle process
namespace: biological_process
def:
  "A multicellular organismal process involved in the periodic casting off and regeneration of an outer covering of cuticle, feathers, hair, horns, skin." [GOC:isa_complete]


id: GO:0022405
name: hair cycle process
namespace: biological_process
def:
  "A multicellular organismal process involved in the cyclical phases of growth (anagen), regression (catagen), quiescence (telogen), and shedding (exogen) in the life of a hair; one of the collection or mass of filaments growing from the skin of an animal, and forming a covering for a part of the head or for any part or the whole of the body." [GOC:isa_complete]


id: GO:0022406
name: membrane docking
namespace: biological_process
def:
  "The initial attachment of a membrane or protein to a target membrane. Docking requires only that the proteins come close enough to interact and adhere." [GOC:isa_complete]


id: GO:0022407
name: regulation of cell-cell adhesion
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of attachment of a cell to another cell." [GOC:isa_complete]


id: GO:0022408
name: negative regulation of cell-cell adhesion
namespace: biological_process
def:
  "Any process that stops, prevents or reduces the rate or extent of cell adhesion to another cell." [GOC:isa_complete]


id: GO:0022409
name: positive regulation of cell-cell adhesion
namespace: biological_process
def:
  "Any process that activates or increases the rate or extent of cell adhesion to another cell." [GOC:isa_complete]


id: GO:0022410
name: circadian sleep/wake cycle process
namespace: biological_process
def:
  "A behavioral process involved in the cycle from wakefulness through an orderly succession of sleep states and stages that occurs on an approximately 24 hour rhythm." [GOC:isa_complete]


id: GO:0022412
name: cellular process involved in reproduction in multicellular organism
namespace: biological_process
def:
  "A process, occurring at the cellular level, that is involved in the reproductive function of a multicellular organism." [GOC:isa_complete]


id: GO:0022413
name: reproductive process in single-celled organism
namespace: biological_process
def:
  "A process, occurring at the cellular level, that is involved in the reproductive function of a single-celled organism." [GOC:isa_complete]


id: GO:0022414
name: reproductive process
namespace: biological_process
def:
  "A biological process that directly contributes to the process of producing new individuals by one or two organisms. The new individuals inherit some proportion of their genetic material from the parent or parents." [GOC:dph, GOC:isa_complete]


id: GO:0022416
name: chaeta development
namespace: biological_process
def:
  "The process whose specific outcome is the progression of a chaeta over time, from its formation to the mature structure. A chaeta is a sensory multicellular cuticular outgrowth of a specifically differentiated cell." [FBbt:00005177, GOC:bf, GOC:cjm, GOC:dos, GOC:isa_complete]


id: GO:0022417
name: protein maturation by protein folding
namespace: biological_process
def:
  "The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure that results in the attainment of the full functional capacity of a protein." [GOC:isa_complete]


id: GO:0022600
name: digestive system process
namespace: biological_process
def:
  "A physical, chemical, or biochemical process carried out by living organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism." [GOC:isa_complete, GOC:jid, GOC:mtg_cardio]


id: GO:0022601
name: menstrual cycle phase
namespace: biological_process
def:
  "The progression of physiological phases, occurring in the endometrium during the menstrual cycle that recur at regular intervals during the reproductive years. The menstrual cycle is an ovulation cycle where the endometrium is shed if pregnancy does not occur." [GOC:dph, GOC:isa_complete, GOC:jid]


id: GO:0022602
name: ovulation cycle process
namespace: biological_process
def:
  "A process involved in the sexual cycle seen in females, often with physiologic changes in the endometrium that recur at regular intervals during the reproductive years." [GOC:isa_complete]


id: GO:0022603
name: regulation of anatomical structure morphogenesis
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of anatomical structure morphogenesis." [GOC:mah]


id: GO:0022604
name: regulation of cell morphogenesis
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of cell morphogenesis. Cell morphogenesis is the developmental process in which the shape of a cell is generated and organized." [GOC:isa_complete]


id: GO:0022605
name: oogenesis stage
namespace: biological_process
def:
  "A reproductive process that is a step in the formation and maturation of an ovum or female gamete from a primordial female germ cell." [GOC:isa_complete, GOC:mtg_sensu]


id: GO:0022606
name: establishment of proximal/distal cell polarity
namespace: biological_process
def:
  "The specification and formation of the polarity of a cell along its proximal/distal axis." [GOC:isa_complete]


id: GO:0022610
name: biological adhesion
namespace: biological_process
def:
  "The attachment of a cell or organism to a substrate, another cell, or other organism. Biological adhesion includes intracellular attachment between membrane regions." [GOC:isa_complete]


id: GO:0022611
name: dormancy process
namespace: biological_process
def:
  "A developmental process in which dormancy (sometimes called a dormant state) is induced, maintained or broken. Dormancy is a suspension of most physiological activity and growth that can be reactivated." [GOC:isa_complete, GOC:PO_curators, PO_REF:00009]


id: GO:0022612
name: gland morphogenesis
namespace: biological_process
def:
  "The process in which the anatomical structures of a gland are generated and organized." [GOC:isa_complete]


id: GO:0022613
name: ribonucleoprotein complex biogenesis
namespace: biological_process
def:
  "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a complex containing RNA and proteins. Includes the biosynthesis of the constituent RNA and protein molecules, and those macromolecular modifications that are involved in synthesis or assembly of the ribonucleoprotein complex." [GOC:isa_complete, GOC:mah]


id: GO:0022614
name: membrane to membrane docking
namespace: biological_process
def:
  "The initial attachment of a membrane to a target membrane, mediated by proteins protruding from the two membranes. Docking requires only that the membranes come close enough for the proteins to interact and adhere." [GOC:isa_complete]


id: GO:0022615
name: protein to membrane docking
namespace: biological_process
def:
  "The initial attachment of a protein to a target membrane, mediated by a proteins protruding from the target membrane. Docking requires only that the proteins come close enough to interact and adhere." [GOC:isa_complete]


id: GO:0022616
name: DNA strand elongation
namespace: biological_process
def:
  "The DNA metabolic process in which a DNA strand is synthesized by adding nucleotides to the 3' end of an existing DNA stand." [GOC:isa_complete]


id: GO:0022618
name: ribonucleoprotein complex assembly
namespace: biological_process
def:
  "The aggregation, arrangement and bonding together of proteins and RNA molecules to form a ribonucleoprotein complex." [GOC:jl]


id: GO:0022619
name: generative cell differentiation
namespace: biological_process
def:
  "The process in which a relatively unspecialized cell acquires specialized features of a generative cell. The generative cell gives rise to the sperm cells in the male gametophyte." [GOC:isa_complete]


id: GO:0022620
name: vegetative cell differentiation
namespace: biological_process
def:
  "The process in which a relatively unspecialized cell acquires specialized features of a vegetative cell. The vegetative cell is gives rise to the pollen tube." [GOC:isa_complete]


id: GO:0022622
name: root system development
namespace: biological_process
def:
  "The process whose specific outcome is the progression of the root system over time, from its formation to the mature structure." [GOC:isa_complete]


id: GO:0022623
name: proteasome-activating nucleotidase complex
namespace: cellular_component
def:
  "A homohexameric complex that recognizes and unfolds core proteasome substrate proteins, and translocates them to the core complex in an ATP dependent manner." [GOC:bf, GOC:mtg_sensu, PMID:19363223, PMID:19481528]


id: GO:0022624
name: proteasome accessory complex
namespace: cellular_component
def:
  "A protein complex, that caps one or both ends of the proteasome core complex and regulates entry into, or exit from, the proteasome core complex." [GOC:mtg_sensu]


id: GO:0022803
name: passive transmembrane transporter activity
namespace: molecular_function
def:
  "Enables the transfer of a solute from one side of the membrane to the other, down the solute's concentration gradient." [GOC:mtg_transport, ISBN:0815340729]


id: GO:0022804
name: active transmembrane transporter activity
namespace: molecular_function
def:
  "Catalysis of the transfer of a specific substance or related group of substances from one side of a membrane to the other, up the solute's concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction." [GOC:mtg_transport, ISBN:0815340729]


id: GO:0022809
name: mobile ion carrier activity
namespace: molecular_function
def:
  "This is a type of carrier produced by bacteria. It enables passive transport by shielding the ion that is being transported from the lipid membrane. It carries an ion across the membrane by enclosing the ion and travelling across the membrane. It does not form a fully open pore across the membrane." [GOC:mtg_transport, GOC:pr, ISBN:0815340729]


id: GO:0022810
name: membrane potential driven uniporter activity
namespace: molecular_function
def:
  "Enables the active transport of a solute across a membrane by a mechanism involving conformational change, where energy for active transport is derived from membrane potential if the solute is charged." [GOC:mtg_transport, ISBN:0815340729]


id: GO:0022814
name: facilitated diffusion
namespace: molecular_function
def:
  "Catalysis of the transfer of a single solute from one side of the membrane to the other by a mechanism involving conformational change, either by facilitated diffusion or in a membrane potential dependent process if the solute is charged." [GOC:mtg_transport, ISBN:0815340729]


id: GO:0022815
name: obsolete large uncharged polar molecule transmembrane transporter activity
namespace: molecular_function
def:
  "OBSOLETE. Catalysis of the transfer of a large uncharged polar molecule from one side of a membrane to the other." [GOC:mtg_transport, ISBN:0815340729]


id: GO:0022818
name: sodium ion uniporter activity
namespace: molecular_function
def:
  "Catalysis of the active transport of a sodium ion across a membrane by a mechanism involving conformational change, where energy for active transport is derived from membrane potential if the solute is charged." [GOC:mtg_transport, ISBN:0815340729]


id: GO:0022819
name: potassium ion uniporter activity
namespace: molecular_function
def:
  "Catalysis of the active transport of a potassium ion across a membrane by a mechanism involving conformational change, where energy for active transport is derived from membrane potential if the solute is charged." [GOC:mtg_transport, ISBN:0815340729]


id: GO:0022820
name: potassium ion symporter activity
namespace: molecular_function
def:
  "Catalysis of the active transport of a potassium ion across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy." [GOC:mtg_transport, ISBN:0815340729]


id: GO:0022821
name: potassium ion antiporter activity
namespace: molecular_function
def:
  "Catalysis of the active transport of a potassium ion across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy." [GOC:mtg_transport, ISBN:0815340729]


id: GO:0022824
name: transmitter-gated ion channel activity
namespace: molecular_function
def:
  "Enables the transmembrane transfer of an ion by a channel that opens when a specific neurotransmitter has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729]


id: GO:0022828
name: phosphorylation-gated channel activity
namespace: molecular_function
def:
  "Enables the transmembrane transfer of a solute by a channel that opens in response to phosphorylation of one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729]


id: GO:0022829
name: wide pore channel activity
namespace: molecular_function
def:
  "Enables the transport of a solute across a membrane via a large pore, un-gated channel. Examples include gap junctions, which transport substances from one cell to another; and porins which transport substances in and out of bacteria, mitochondria and chloroplasts." [GOC:mtg_transport, ISBN:0815340729]


id: GO:0022831
name: narrow pore, gated channel activity
namespace: molecular_function
def:
  "Enables the transport of a solute across a membrane via a narrow pore channel that opens in response to a particular stimulus." [GOC:mtg_transport, ISBN:0815340729]


id: GO:0022832
name: voltage-gated channel activity
namespace: molecular_function
def:
  "Enables the transmembrane transfer of a solute by a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:mtg_transport, ISBN:0815340729]


id: GO:0022833
name: mechanically gated channel activity
namespace: molecular_function
def:
  "Enables the transmembrane transfer of a solute by a channel that opens in response to a mechanical stress." [GOC:mtg_transport, ISBN:0815340729]


id: GO:0022834
name: ligand-gated channel activity
namespace: molecular_function
def:
  "Enables the transmembrane transfer of a solute by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729]


id: GO:0022835
name: transmitter-gated channel activity
namespace: molecular_function
def:
  "Enables the transmembrane transfer of a solute by a channel that opens when a specific neurotransmitter has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729]


id: GO:0022836
name: gated channel activity
namespace: molecular_function
def:
  "Enables the transmembrane transfer of a solute by a channel that opens in response to a specific stimulus." [GOC:mtg_transport]


id: GO:0022838
name: substrate-specific channel activity
namespace: molecular_function
def:
  "Enables the energy-independent facilitated diffusion, mediated by passage of a specific solute through a transmembrane aqueous pore or channel. Stereospecificity is not exhibited but this transport may be specific for a particular molecular species or class of molecules." [GOC:mtg_transport]


id: GO:0022839
name: ion gated channel activity
namespace: molecular_function
def:
  "Enables the transmembrane transfer of a solute by a channel that opens in response to a specific ion stimulus." [GOC:mtg_transport]


id: GO:0022840
name: leak channel activity
namespace: molecular_function
def:
  "Enables the transport of a solute across a membrane via a narrow pore channel that is open even in an unstimulated or 'resting' state." [GOC:mtg_transport, ISBN:0815340729]


id: GO:0022841
name: potassium ion leak channel activity
namespace: molecular_function
def:
  "Enables the transport of a potassium ion across a membrane via a narrow pore channel that is open even in an unstimulated or 'resting' state." [GOC:mtg_transport, ISBN:0815340729]


id: GO:0022842
name: narrow pore channel activity
namespace: molecular_function
def:
  "Enables the transport of a solute across a membrane via a narrow pore channel that may be gated or ungated." [GOC:mtg_transport, ISBN:0815340729]


id: GO:0022843
name: voltage-gated cation channel activity
namespace: molecular_function
def:
  "Enables the transmembrane transfer of a cation by a voltage-gated channel. A cation is a positively charged ion. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:mtg_transport, ISBN:0815340729]


id: GO:0022848
name: acetylcholine-gated cation channel activity
namespace: molecular_function
def:
  "Enables the transmembrane transfer of a cation by a channel that opens when acetylcholine has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729]


id: GO:0022849
name: glutamate-gated calcium ion channel activity
namespace: molecular_function
def:
  "Enables the transmembrane transfer of a calcium ion by a channel that opens when glutamate has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729]


id: GO:0022850
name: serotonin-gated cation channel activity
namespace: molecular_function
def:
  "Enables the transmembrane transfer of a cation by a channel that opens when serotonin has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729]


id: GO:0022851
name: GABA-gated chloride ion channel activity
namespace: molecular_function
def:
  "Enables the transmembrane transfer of a chloride ion by a channel that opens when GABA has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729]


id: GO:0022852
name: glycine-gated chloride ion channel activity
namespace: molecular_function
def:
  "Enables the transmembrane transfer of a chloride ion by a channel that opens when glycine has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729]


id: GO:0022853
name: active ion transmembrane transporter activity
namespace: molecular_function
def:
  "Catalysis of the transfer of an ion from one side of a membrane to the other up the solute's concentration gradient. This is carried out by binding the solute and undergoing a series of conformational changes. Transport works equally well in either direction." [GOC:mtg_transport, ISBN:0815340729]


id: GO:0022854
name: obsolete active large uncharged polar molecule transmembrane transporter activity
namespace: molecular_function
def:
  "OBSOLETE. Catalysis of the transfer of a large uncharged polar molecule from one side of the membrane to the other, up the solute's concentration gradient, by binding the solute and undergoing a series of conformational changes. Transport works equally well in either direction." [GOC:mtg_transport, ISBN:0815340729]


id: GO:0022855
name: protein-N(PI)-phosphohistidine-glucose phosphotransferase system transporter activity
namespace: molecular_function
def:
  "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + glucose(out) = protein histidine + glucose phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport." [GOC:mtg_transport, ISBN:0815340729]


id: GO:0022856
name: protein-N(PI)-phosphohistidine-sorbitol phosphotransferase system transporter activity
namespace: molecular_function
def:
  "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + sorbitol(out) = protein histidine + sorbitol phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport." [GOC:mtg_transport, ISBN:0815340729]


id: GO:0022857
name: transmembrane transporter activity
namespace: molecular_function
def:
  "Enables the transfer of a substance from one side of a membrane to the other." [GOC:mtg_transport, ISBN:0815340729]


id: GO:0022858
name: alanine transmembrane transporter activity
namespace: molecular_function
def:
  "Enables the transfer of alanine from one side of a membrane to the other. Alanine is 2-aminopropanoic acid." [GOC:mtg_transport, ISBN:0815340729]


id: GO:0022859
name: dephosphorylation-gated channel activity
namespace: molecular_function
def:
  "Enables the transmembrane transfer of a solute by a channel that opens in response to dephosphorylation of one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729]


id: GO:0022865
name: transmembrane electron transfer carrier
namespace: molecular_function
def:
  "Enables electron flow across a biological membrane, from donors localized on one side of the membrane to acceptors localized on the other side. These systems contribute to or subtract from the membrane potential, depending on the direction of electron flow. They are therefore important to cellular energetics." [GOC:mtg_transport, ISBN:0815340729, TC:5]


id: GO:0022869
name: protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
namespace: molecular_function
def:
  "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + lactose(out) = protein histidine + lactose phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport." [GOC:mtg_transport, ISBN:0815340729]


id: GO:0022870
name: protein-N(PI)-phosphohistidine-mannose phosphotransferase system transporter activity
namespace: molecular_function
def:
  "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + mannose(out) = protein histidine + mannose phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport." [GOC:mtg_transport, ISBN:0815340729]


id: GO:0022871
name: protein-N(PI)-phosphohistidine-sorbose phosphotransferase system transporter activity
namespace: molecular_function
def:
  "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + sorbose(out) = protein histidine + sorbose phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport." [GOC:mtg_transport, ISBN:0815340729]


id: GO:0022872
namespace: molecular_function
name:
  protein-N(PI)-phosphohistidine-mannitol phosphotransferase system transmembrane transporter activity

def:
  "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + mannitol(out) = protein histidine + mannitol phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport." [GOC:mtg_transport, ISBN:0815340729]


id: GO:0022873
name: protein-N(PI)-phosphohistidine-maltose phosphotransferase system transporter activity
namespace: molecular_function
def:
  "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + maltose(out) = protein histidine + maltose phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport." [GOC:mtg_transport, ISBN:0815340729]


id: GO:0022874
name: protein-N(PI)-phosphohistidine-cellobiose phosphotransferase system transporter activity
namespace: molecular_function
def:
  "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + cellobiose(out) = protein histidine + cellobiose phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport." [GOC:mtg_transport, ISBN:0815340729]


id: GO:0022875
namespace: molecular_function
name:
  protein-N(PI)-phosphohistidine-galactitol phosphotransferase system transmembrane transporter activity

def:
  "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + galactitol(out) = protein histidine + galactitol phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport." [GOC:mtg_transport, ISBN:0815340729]


id: GO:0022876
name: protein-N(PI)-phosphohistidine-galactosamine phosphotransferase system transporter activity
namespace: molecular_function
def:
  "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + galactosamine(out) = protein histidine + galactosamine phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport." [GOC:mtg_transport, ISBN:0815340729]


id: GO:0022877
name: protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
namespace: molecular_function
def:
  "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + fructose(out) = protein histidine + fructose phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport." [GOC:mtg_transport, ISBN:0815340729]


id: GO:0022878
name: protein-N(PI)-phosphohistidine-sucrose phosphotransferase system transporter activity
namespace: molecular_function
def:
  "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + sucrose(out) = protein histidine + sucrose phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport." [GOC:mtg_transport, ISBN:0815340729]


id: GO:0022879
name: protein-N(PI)-phosphohistidine-trehalose phosphotransferase system transporter activity
namespace: molecular_function
def:
  "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + trehalose(out) = protein histidine + trehalose phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport." [GOC:mtg_transport, ISBN:0815340729]


id: GO:0022880
name: protein-N(PI)-phosphohistidine-N-acetylglucosamine phosphotransferase system transporter activity
namespace: molecular_function
def:
  "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + N-acetylglucosamine(out) = protein histidine + N-acetylglucosamine phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport." [GOC:mtg_transport, ISBN:0815340729]


id: GO:0022881
name: protein-N(PI)-phosphohistidine-N-acetylgalactosamine phosphotransferase system transporter activity
namespace: molecular_function
def:
  "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + N-acetylgalactosamine(out) = protein histidine + N-acetylgalactosamine phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport." [GOC:mtg_transport, ISBN:0815340729]


id: GO:0022882
name: protein-N(PI)-phosphohistidine-beta-glucoside phosphotransferase system transporter activity
namespace: molecular_function
def:
  "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + beta-glucoside(out) = protein histidine + beta-glucoside phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport." [GOC:mtg_transport, ISBN:0815340729]


id: GO:0022883
name: zinc efflux transmembrane transporter activity
namespace: molecular_function
def:
  "Catalysis of the transfer of a zinc ion or zinc ions from the inside of the cell to the outside of the cell across a membrane." [GOC:mtg_transport, ISBN:0815340729]


id: GO:0022884
name: macromolecule transmembrane transporter activity
namespace: molecular_function
def:
  "Enables the transfer of a macromolecule from one side of the membrane to the other." [GOC:mtg_transport, ISBN:0815340729]


id: GO:0022885
name: bacteriocin transmembrane transporter activity
namespace: molecular_function
def:
  "Enables the transfer of a bacteriocin from one side of the membrane to the other." [GOC:mtg_transport, ISBN:0815340729]


id: GO:0022886
name: channel-forming ionophore activity
namespace: molecular_function
def:
  "Enables transport of a solute across a membrane. This kind of transporter interacts much more weakly with the solute than the carrier does. It is an aqueous pore that extends across the membrane. It may change from closed to open and back. It transports faster than a carrier. It is always passive." [GOC:mtg_transport, ISBN:0815340729]


id: GO:0022889
name: serine transmembrane transporter activity
namespace: molecular_function
def:
  "Enables the transfer of serine from one side of a membrane to the other. Serine is 2-amino-3-hydroxypropanoic acid." [GOC:mtg_transport, ISBN:0815340729]


id: GO:0022890
name: inorganic cation transmembrane transporter activity
namespace: molecular_function
def:
  "Enables the transfer of inorganic cations from one side of a membrane to the other. Inorganic cations are atoms or small molecules with a positive charge that do not contain carbon in covalent linkage." [GOC:ai, GOC:mtg_transport, ISBN:0815340729]


id: GO:0022891
name: substrate-specific transmembrane transporter activity
namespace: molecular_function
def:
  "Enables the transfer of a specific substance or group of related substances from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729]


id: GO:0022892
name: substrate-specific transporter activity
namespace: molecular_function
def:
  "Enables the directed movement of a specific substance or group of related substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:mtg_transport]


id: GO:0022893
name: low-affinity tryptophan transmembrane transporter activity
namespace: molecular_function
def:
  "Catalysis of the low-affinity transfer of L-tryptophan from one side of a membrane to the other. Tryptophan is 2-amino-3-(1H-indol-3-yl)propanoic acid. In low-affinity transport the transporter is able to bind the solute only if it is present at very high concentrations." [GOC:mtg_transport, ISBN:0815340729]


id: GO:0022894
name: Intermediate conductance calcium-activated potassium channel activity
namespace: molecular_function
def:
  "Enables the transmembrane transfer of potassium by a channel with a unit conductance of 20 to 85 picoSiemens that opens in response to stimulus by internal calcium ions. Intermediate conductance calcium-activated potassium channels are more sensitive to calcium than are large conductance calcium-activated potassium channels. Transport by a channel involves catalysis of facilitated diffusion of a solute (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel, without evidence for a carrier-mediated mechanism." [GOC:mtg_transport, OMIM:602754]


id: GO:0022897
name: proton-dependent peptide secondary active transmembrane transporter activity
namespace: molecular_function
def:
  "Catalysis of the transfer of a peptide from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by proton movement." [GOC:mtg_transport]


id: GO:0022898
name: regulation of transmembrane transporter activity
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of transmembrane transporter activity." [GOC:dph, GOC:mtg_cardio, GOC:mtg_transport]


id: GO:0022900
name: electron transport chain
namespace: biological_process
def:
  "A process in which a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient." [GOC:mtg_electron_transport]


id: GO:0022904
name: respiratory electron transport chain
namespace: biological_process
def:
  "A process in which a series of electron carriers operate together to transfer electrons from donors such as NADH and FADH2 to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient." [GOC:mtg_electron_transport, ISBN:0716720094]


id: GO:0023002
name: nuclear migration to embryo sac poles
namespace: biological_process
def:
  "Migration of the nuclei of the two-nucleate embryo sac to opposite poles of the cell." [GOC:jid, GOC:mtg_plant, ISBN:047186840X]


id: GO:0023003
name: nuclear migration to the embryo sac center
namespace: biological_process
def:
  "Migration of one of the four nuclei at each pole of the eight-nucleate embryo sac, to the center of the cell." [GOC:jid, GOC:mtg_plant, ISBN:047186840X]


id: GO:0023004
name: obsolete activation of dopamine receptor signaling pathway
namespace: biological_process
def:
  "OBSOLETE. Any process that initiates the dopamine receptor protein signaling pathway through stimulation of the dopamine receptor." [GOC:mtg_signal]


id: GO:0023005
name: obsolete signal initiation by neurotransmitter
namespace: biological_process
def:
  "OBSOLETE. The process in which a neurotransmitter signal causes activation of a receptor." [GOC:mtg_signal]


id: GO:0023006
name: obsolete signal initiation by amino acid
namespace: biological_process
def:
  "OBSOLETE. The process in which an amino acid signal causes activation of a receptor." [GOC:mtg_signal]


id: GO:0023007
name: obsolete ligand binding to T cell receptor
namespace: biological_process
def:
  "OBSOLETE. Binding of a diffusible ligand to a T cell receptor as part of a signaling process." [GOC:jid, GOC:mtg_signal]


id: GO:0023009
name: obsolete initiation of T cell receptor signaling
namespace: biological_process
def:
  "OBSOLETE. The process in which a signal causes activation of T cell receptor signaling." [GOC:mtg_signal]


id: GO:0023010
name: obsolete regulation of initiation of T cell receptor signaling
namespace: biological_process
def:
  "OBSOLETE. Any process that modulates the frequency, rate or extent of the initiation of T cell receptor signaling." [GOC:mtg_signal]


id: GO:0023011
name: obsolete positive regulation of initiation of T cell receptor signaling
namespace: biological_process
def:
  "OBSOLETE. Any process that activates, maintains or increases the frequency, rate or extent of the initiation of T cell receptor signaling." [GOC:mtg_signal]


id: GO:0023012
name: obsolete initiation of T cell receptor signaling by binding of a MHC complex to T cell receptor
namespace: biological_process
def:
  "OBSOLETE. The process in which binding of an MHC complex to T cell receptor causes activation of T cell receptor signaling." [GOC:mtg_signal]


id: GO:0023014
name: signal transduction by protein phosphorylation
namespace: biological_process
def:
  "A process in which the transfer of one or more phosphate groups to a substrate transmits a signal to the phosphorylated substrate." [GOC:mtg_signal, GOC:signaling]


id: GO:0023015
name: signal transduction by cis-phosphorylation
namespace: biological_process
def:
  "A process in which the transfer of one or more phosphate groups by a kinase to a residue in the same kinase molecule transmits a signal. For example, ligand-binding can induce autophosphorylation of the activated receptor, creating binding sites for intracellular signaling molecules." [GOC:bf, GOC:mtg_signal, GOC:signaling]


id: GO:0023016
name: signal transduction by trans-phosphorylation
namespace: biological_process
def:
  "A process in which the transfer of one or more phosphate groups by a kinase to a residue in a different protein molecule transmits a signal." [GOC:bf, GOC:mtg_signal]


id: GO:0023018
name: obsolete T cell activation of signal transmission via diffusible molecule
namespace: biological_process
def:
  "OBSOLETE. The process in which signal transmission via a diffusible molecule is initiated by a T cell." [GOC:mtg_signal]


id: GO:0023019
name: signal transduction involved in regulation of gene expression
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of gene expression as a consequence of a process in which a signal is released and/or conveyed from one location to another." [GOC:mtg_signal]


id: GO:0023020
name: obsolete regulation of gene expression as a consequence of T cell signal transmission
namespace: biological_process
def:
  "OBSOLETE. Any process that modulates the frequency, rate or extent of gene expression as a consequence of a process in which a T cell signal is released and/or conveyed from one location to another." [GOC:mtg_signal]


id: GO:0023021
name: termination of signal transduction
namespace: biological_process
def:
  "The signaling process in which signal transduction is brought to an end rather than being reversibly modulated." [GOC:mtg_signal]


id: GO:0023022
name: termination of T cell signal transduction
namespace: biological_process
def:
  "The signaling process in which T cell signal transduction is brought to an end rather than being reversibly modulated." [GOC:mtg_signal]


id: GO:0023023
name: MHC protein complex binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with the major histocompatibility complex." [GOC:mtg_signal, GOC:vw]


id: GO:0023024
name: MHC class I protein complex binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with the class I major histocompatibility complex." [GOC:mtg_signal, GOC:vw]


id: GO:0023025
name: MHC class Ib protein complex binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with the class Ib major histocompatibility complex." [GOC:mtg_signal, GOC:vw]


id: GO:0023026
name: MHC class II protein complex binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with the class II major histocompatibility complex." [GOC:mtg_signal, GOC:vw]


id: GO:0023027
name: MHC class I protein binding, via antigen binding groove
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with major histocompatibility complex class I molecules via the antigen binding groove." [GOC:mtg_signal, GOC:vw]


id: GO:0023028
name: MHC class I protein binding, via lateral surface
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with major histocompatibility complex class I molecules via the lateral surface." [GOC:mtg_signal, GOC:vw]


id: GO:0023029
name: MHC class Ib protein binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with major histocompatibility complex class Ib molecules." [GOC:mtg_signal, GOC:vw]


id: GO:0023030
name: MHC class Ib protein binding, via antigen binding groove
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with major histocompatibility complex class Ib molecules via the antigen binding groove." [GOC:mtg_signal, GOC:vw]


id: GO:0023031
name: MHC class Ib protein binding, via lateral surface
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with major histocompatibility complex class Ib molecules via the lateral surface." [GOC:mtg_signal, GOC:vw]


id: GO:0023035
name: CD40 signaling pathway
namespace: biological_process
def:
  "A series of molecular signals initiated by the binding of the cell surface receptor CD40 to one of its physiological ligands, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:mtg_signal, GOC:signaling, PMID:11348017]


id: GO:0023036
name: obsolete initiation of signal transduction
namespace: biological_process
def:
  "OBSOLETE. The process in which a signal causes activation of a receptor, for example, via a conformation change." [GOC:mtg_signal]


id: GO:0023038
name: obsolete signal initiation by diffusible mediator
namespace: biological_process
def:
  "OBSOLETE. The process in which a diffusible signal causes activation of a receptor." [GOC:mtg_signal]


id: GO:0023039
name: obsolete signal initiation by physical damage
namespace: biological_process
def:
  "OBSOLETE. The process in which a physical damage signal causes activation of a receptor." [GOC:mtg_signal]


id: GO:0023040
name: obsolete signaling via ionic flux
namespace: biological_process
def:
  "OBSOLETE. The process in which information is sent from one location to another, within a living organism or between living organisms, via ionic flux." [GOC:mtg_signal]


id: GO:0023041
name: neuronal signal transduction
namespace: biological_process
def:
  "The process in which an activated neuronal cell receptor conveys information down a signaling pathway, resulting in a change in the function or state of a cell. This process may be intracellular or intercellular." [GOC:mtg_signal]


id: GO:0023042
name: obsolete signaling via protein/peptide mediator
namespace: biological_process
def:
  "OBSOLETE. The process in which information is sent from one location to another, within a living organism or between living organisms, via a protein/peptide mediator." [GOC:mtg_signal]


id: GO:0023043
name: obsolete signaling via lipid mediator
namespace: biological_process
def:
  "OBSOLETE. The process in which information is sent from one location to another, within a living organism or between living organisms, via a lipid mediator." [GOC:mtg_signal]


id: GO:0023044
name: obsolete signaling via chemical mediator
namespace: biological_process
def:
  "OBSOLETE. The process in which information is sent from one location to another, within a living organism or between living organisms, via a chemical mediator." [GOC:mtg_signal]


id: GO:0023045
name: signal transduction by conformational transition
namespace: biological_process
def:
  "A process where induction of a conformational change in a molecule transmits a signal to that molecule." [GOC:bf, GOC:mtg_signal]


id: GO:0023047
name: obsolete signal initiation by chemical mediator
namespace: biological_process
def:
  "OBSOLETE. The process in which a chemical signal causes activation of a receptor." [GOC:mtg_signal]


id: GO:0023049
name: obsolete signal initiation by protein/peptide mediator
namespace: biological_process
def:
  "OBSOLETE. The process in which a protein/peptide signal causes activation of a receptor." [GOC:mtg_signal]


id: GO:0023050
name: obsolete consequence of signal transmission
namespace: biological_process
def:
  "OBSOLETE. The steps whereby the downstream processes started by a signal are brought to a conclusion. Examples include destruction of cAMP by PDE, or endocytosis resulting from receptor phosphorylation. The termination process ends when the receptor has returned to its inactive state." [GOC:mtg_signal]


id: GO:0023052
name: signaling
namespace: biological_process
def:
  "The entirety of a process in which information is transmitted within a biological system. This process begins with an active signal and ends when a cellular response has been triggered." [GOC:mtg_signal, GOC:mtg_signaling_feb11, GOC:signaling]


id: GO:0023053
name: obsolete signal initiation by mechanical effect
namespace: biological_process
def:
  "OBSOLETE. The process in which a mechanical signal causes activation of a receptor." [GOC:mtg_signal]


id: GO:0023056
name: positive regulation of signaling
namespace: biological_process
def:
  "Any process that activates, maintains or increases the frequency, rate or extent of a signaling process." [GOC:mtg_signal]


id: GO:0023057
name: negative regulation of signaling
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of a signaling process." [GOC:mtg_signal]


id: GO:0023058
name: adaptation of signaling pathway
namespace: biological_process
def:
  "The regulation of a signal transduction pathway in response to a stimulus upon prolonged exposure to that stimulus." [GOC:mtg_signal]


id: GO:0023059
name: positive adaptation of signaling pathway
namespace: biological_process
def:
  "The positive regulation of a signal transduction pathway in response to a stimulus upon prolonged exposure to that stimulus." [GOC:mtg_signal]


id: GO:0023060
name: obsolete signal transmission
namespace: biological_process
def:
  "OBSOLETE. The process in which a signal is released and/or conveyed from one location to another." [GOC:mtg_signal]


id: GO:0023061
name: signal release
namespace: biological_process
def:
  "The process in which a signal is secreted or discharged into the extracellular medium from a cellular source." [GOC:mtg_signal]


id: GO:0023062
name: obsolete signal transmission via transcytosis
namespace: biological_process
def:
  "OBSOLETE. The process in which a signal is conveyed via transcytosis. Transcytosis is the directed movement of endocytosed material through the cell and its exocytosis from the plasma membrane at the opposite side." [GOC:mtg_signal, ISBN:0716731363]


id: GO:0030001
name: metal ion transport
namespace: biological_process
def:
  "The directed movement of metal ions, any metal ion with an electric charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai]


id: GO:0030002
name: cellular anion homeostasis
namespace: biological_process
def:
  "Any process involved in the maintenance of an internal steady state of anions at the level of a cell." [GOC:ceb, GOC:mah]


id: GO:0030003
name: cellular cation homeostasis
namespace: biological_process
def:
  "Any process involved in the maintenance of an internal steady state of cations at the level of a cell." [GOC:ceb, GOC:mah]


id: GO:0030004
name: cellular monovalent inorganic cation homeostasis
namespace: biological_process
def:
  "Any process involved in the maintenance of an internal steady state of monovalent inorganic cations at the level of a cell." [GOC:ai, GOC:mah]


id: GO:0030005
name: obsolete cellular di-, tri-valent inorganic cation homeostasis
namespace: biological_process
def:
  "Any process involved in the maintenance of an internal steady state of divalent or trivalent cations at the level of a cell." [GOC:ceb, GOC:mah]


id: GO:0030006
name: obsolete heavy cellular metal ion homeostasis
namespace: biological_process
def:
  "OBSOLETE. Regulation of the levels, transport, and metabolism of ions of a heavy metal, a metal that can form a coordination bond with a protein, as opposed to an alkali or alkaline-earth metal that can only form an ionic bond; this definition includes the following biologically relevant heavy metals: Cd, Co, Cu, Fe, Hg, Mn, Mo, Ni, V, W, Zn." [GOC:kd, GOC:mah]


id: GO:0030007
name: cellular potassium ion homeostasis
namespace: biological_process
def:
  "Any process involved in the maintenance of an internal steady state of potassium ions at the level of a cell." [GOC:mah]


id: GO:0030008
name: TRAPP complex
namespace: cellular_component
def:
  "A large complex that acts as a tethering factor involved in transporting vesicles from the ER through the Golgi to the plasma membrane. A TRAPP (transport protein particle) complex has a core set of proteins which are joined by specific subunits depending on the cellular component where a given TRAPP complex is active." [GOC:bhm, GOC:vw, PMID:22669257]


id: GO:0030010
name: establishment of cell polarity
namespace: biological_process
def:
  "The specification and formation of anisotropic intracellular organization or cell growth patterns." [GOC:mah]


id: GO:0030011
name: maintenance of cell polarity
namespace: biological_process
def:
  "The maintenance of established anisotropic intracellular organization or cell growth patterns." [GOC:mah]


id: GO:0030014
name: CCR4-NOT complex
namespace: cellular_component
def:
  "The evolutionarily conserved CCR4-NOT complex is involved in several aspects of mRNA metabolism, including repression and activation of mRNA initiation, control of mRNA elongation, and the deadenylation and subsequent degradation of mRNA. In Saccharomyces the CCR4-NOT complex comprises a core complex of 9 proteins (Ccr4p, Caf1p, Caf40p, Caf130p, Not1p, Not2p, Not3p, Not4p, and Not5p), Caf4p, Caf16p, and several less well characterized proteins." [GOC:sart, PMID:11113136]


id: GO:0030015
name: CCR4-NOT core complex
namespace: cellular_component
def:
  "The core of the CCR4-NOT complex. In Saccharomyces the CCR4-NOT core complex comprises Ccr4p, Caf1p, Caf40p, Caf130p, Not1p, Not2p, Not3p, Not4p, and Not5p." [GOC:sart, PMID:11113136]


id: GO:0030016
name: myofibril
namespace: cellular_component
def:
  "The contractile element of skeletal and cardiac muscle; a long, highly organized bundle of actin, myosin, and other proteins that contracts by a sliding filament mechanism." [ISBN:0815316194]


id: GO:0030017
name: sarcomere
namespace: cellular_component
def:
  "The repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs." [ISBN:0815316194]


id: GO:0030018
name: Z disc
namespace: cellular_component
def:
  "Platelike region of a muscle sarcomere to which the plus ends of actin filaments are attached." [GOC:mtg_muscle, ISBN:0815316194]


id: GO:0030019
name: obsolete tryptase activity
namespace: molecular_function
def:
  "OBSOLETE. Catalysis of the preferential cleavage of Arg-Xaa, Lys-Xaa, but with more restricted specificity than trypsin." [EC:3.4.21.59]


id: GO:0030020
name: extracellular matrix structural constituent conferring tensile strength
namespace: molecular_function
def:
  "A constituent of the extracellular matrix that enables the matrix to resist longitudinal stress." [GOC:mah, ISBN:0815316194]


id: GO:0030021
name: extracellular matrix structural constituent conferring compression resistance
namespace: molecular_function
def:
  "A constituent of the extracellular matrix that enables the matrix to resist compressive forces; often a proteoglycan." [GOC:mah, ISBN:0815316194]


id: GO:0030022
name: obsolete adhesive extracellular matrix constituent
namespace: molecular_function
def:
  "OBSOLETE. A constituent of the extracellular matrix that facilitates attachment of cells to the matrix." [GOC:mah, ISBN:0815316194]


id: GO:0030023
name: extracellular matrix constituent conferring elasticity
namespace: molecular_function
def:
  "A component of the extracellular matrix that enables the matrix to recoil after transient stretching." [GOC:mah, ISBN:0815316194]


id: GO:0030026
name: cellular manganese ion homeostasis
namespace: biological_process
def:
  "Any process involved in the maintenance of an internal steady state of manganese ions at the level of a cell." [GOC:mah]


id: GO:0030027
name: lamellipodium
namespace: cellular_component
def:
  "A thin sheetlike process extended by the leading edge of a migrating cell or extending cell process; contains a dense meshwork of actin filaments." [ISBN:0815316194]


id: GO:0030029
name: actin filament-based process
namespace: biological_process
def:
  "Any cellular process that depends upon or alters the actin cytoskeleton, that part of the cytoskeleton comprising actin filaments and their associated proteins." [GOC:mah]


id: GO:0030030
name: cell projection organization
namespace: biological_process
def:
  "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a prolongation or process extending from a cell, e.g. a flagellum or axon." [GOC:jl, GOC:mah, http://www.cogsci.princeton.edu/~wn/]


id: GO:0030031
name: cell projection assembly
namespace: biological_process
def:
  "Formation of a prolongation or process extending from a cell, e.g. a flagellum or axon." [GOC:jl, GOC:mah, http://www.cogsci.princeton.edu/~wn/]


id: GO:0030032
name: lamellipodium assembly
namespace: biological_process
def:
  "Formation of a lamellipodium, a thin sheetlike extension of the surface of a migrating cell." [GOC:mah, ISBN:0815316194]


id: GO:0030033
name: microvillus assembly
namespace: biological_process
def:
  "Formation of a microvillus, a thin cylindrical membrane-covered projection on the surface of a cell." [GOC:mah, ISBN:0815316194]


id: GO:0030035
name: microspike assembly
namespace: biological_process
def:
  "Formation of a microspike, a dynamic, actin-rich projection extending from the surface of a migrating animal cell." [ISBN:0815316194, PMID:11429692, PMID:12153987, PMID:19095735]


id: GO:0030036
name: actin cytoskeleton organization
namespace: biological_process
def:
  "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins." [GOC:dph, GOC:jl, GOC:mah]


id: GO:0030037
name: actin filament reorganization involved in cell cycle
namespace: biological_process
def:
  "The cell cycle process in which rearrangement of the spatial distribution of actin filaments and associated proteins occurs." [GOC:mah]


id: GO:0030038
name: contractile actin filament bundle assembly
namespace: biological_process
def:
  "Assembly of actin filament bundles in which the filaments are loosely packed (approximately 30-60 nm apart) and arranged with opposing polarities; the loose packing allows myosin (usually myosin-II) to enter the bundle." [GOC:mah, ISBN:0815316194]


id: GO:0030043
name: actin filament fragmentation
namespace: biological_process
def:
  "The severing of actin filaments into numerous short fragments, usually mediated by actin severing proteins." [GOC:mah, ISBN:0815316194]


id: GO:0030046
name: parallel actin filament bundle assembly
namespace: biological_process
def:
  "Assembly of actin filament bundles in which the filaments are tightly packed (approximately 10-20 nm apart) and oriented with the same polarity." [GOC:mah, ISBN:0815316194]


id: GO:0030048
name: actin filament-based movement
namespace: biological_process
def:
  "Movement of organelles or other particles along actin filaments, or sliding of actin filaments past each other, mediated by motor proteins." [GOC:BHF, GOC:mah]


id: GO:0030049
name: muscle filament sliding
namespace: biological_process
def:
  "The sliding of actin thin filaments and myosin thick filaments past each other in muscle contraction. This involves a process of interaction of myosin located on a thick filament with actin located on a thin filament. During this process ATP is split and forces are generated." [GOC:mah, GOC:mtg_muscle, ISBN:0815316194]


id: GO:0030051
name: obsolete FK506-sensitive peptidyl-prolyl cis-trans isomerase
namespace: molecular_function
def:
  "OBSOLETE. Interacts selectively with the immunosuppressant FK506, and possesses peptidyl-prolyl isomerase activity (catalysis of the reaction: peptidoproline (omega=180) = peptidylproline (omega=0))." [EC:5.2.1.8, ISBN:0198596732]


id: GO:0030052
name: obsolete parvulin
namespace: molecular_function
def:
  "OBSOLETE. A peptidyl-prolyl isomerase isolated from Escherichia coli. It does not have any function as an immunophilin." [ISBN:0198506732]


id: GO:0030053
name: obsolete immunophilin
namespace: molecular_function
def:
  "OBSOLETE. Any member of a family of receptors that includes the major FK506 binding protein FKBP and cyclophilin. These two proteins are unrelated in amino-acid sequence, but both possess peptidyl-prolyl isomerase activity which is blocked by immunosuppressants that block signal-transduction pathways leading to T cell activation such as FK506 and rapamycin, which block FKBP, or cyclosporin A, which blocks cyclophilin." [ISBN:0198506732]


id: GO:0030054
name: cell junction
namespace: cellular_component
def:
  "A cellular component that forms a specialized region of connection between two or more cells or between a cell and the extracellular matrix. At a cell junction, anchoring proteins extend through the plasma membrane to link cytoskeletal proteins in one cell to cytoskeletal proteins in neighboring cells or to proteins in the extracellular matrix." [GOC:mah, http://www.vivo.colostate.edu/hbooks/cmb/cells/pmemb/junctions_a.html, ISBN:0198506732]


id: GO:0030055
name: cell-substrate junction
namespace: cellular_component
def:
  "A cell junction that forms a connection between a cell and the extracellular matrix." [GOC:hb, GOC:mah]


id: GO:0030056
name: hemidesmosome
namespace: cellular_component
def:
  "A cell-substrate junction (attachment structure) found in epithelial cells that links intermediate filaments to extracellular matrices via transmembrane complexes. In vertebrates, hemidesmosomes mediate contact between the basal side of epithelial cells and the basal lamina. In C. elegans, hemidesmosomes connect epithelial cells to distinct extracellular matrices on both the apical and basal cell surfaces." [GOC:kmv, ISBN:0815316208, PMID:20205195]


id: GO:0030057
name: desmosome
namespace: cellular_component
def:
  "A cell-cell junction in which: on the cytoplasmic surface of each interacting plasma membrane is a dense plaque composed of a mixture of intracellular anchor proteins; a bundle of keratin intermediate filaments is attached to the surface of each plaque; transmembrane adhesion proteins of the cadherin family bind to the plaques and interact through their extracellular domains to hold the adjacent membranes together by a Ca2+-dependent mechanism." [GOC:mah, GOC:mtg_muscle, ISBN:0815332181]


id: GO:0030058
name: amine dehydrogenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: R-CH2-NH2 + H2O + acceptor = R-CHO + NH3 + reduced acceptor." [EC:1.4.99.3]


id: GO:0030059
name: aralkylamine dehydrogenase (azurin) activity
namespace: molecular_function
def:
  "Catalysis of the reaction: H(2)O + arCH(2)NH(2) + 2 azurin = 2 reduced azurin + ArCHO + NH(3). The symbol arCH(2)NH(2) represents an aralkylamine and ArCHO is an aryl aldehyde." [EC:1.4.9.2]


id: GO:0030061
name: mitochondrial crista
namespace: cellular_component
def:
  "Any of the inward folds of the mitochondrial inner membrane. Their number, extent, and shape differ in mitochondria from different tissues and organisms. They appear to be devices for increasing the surface area of the mitochondrial inner membrane, where the enzymes of electron transport and oxidative phosphorylation are found. Their shape can vary with the respiratory state of the mitochondria." [ISBN:0198506732]


id: GO:0030062
name: mitochondrial tricarboxylic acid cycle enzyme complex
namespace: cellular_component
def:
  "Any of the heteromeric enzymes, located in the mitochondrion, that act in the tricarboxylic acid (TCA) cycle." [GOC:mah, GOC:mtg_sensu]


id: GO:0030063
name: obsolete murein sacculus
namespace: cellular_component
def:
  "OBSOLETE. A structure formed of the cross-linked polymer peptidoglycan (also called murein) that forms a covalently closed net around a bacterial cell, and imparts structural stability to the bacterial cell wall." [GOC:mah, PMID:9529891]


id: GO:0030070
name: insulin processing
namespace: biological_process
def:
  "The formation of mature insulin by proteolysis of the precursor preproinsulin. The signal sequence is first cleaved from preproinsulin to form proinsulin; proinsulin is then cleaved to release the C peptide, leaving the A and B chains of mature insulin linked by disulfide bridges." [ISBN:0198506732]


id: GO:0030071
name: regulation of mitotic metaphase/anaphase transition
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of the onset of anaphase (chromosome movement) in the mitotic cell cycle." [GOC:mah]


id: GO:0030073
name: insulin secretion
namespace: biological_process
def:
  "The regulated release of proinsulin from secretory granules (B granules) in the B cells of the pancreas; accompanied by cleavage of proinsulin to form mature insulin." [GOC:mah, ISBN:0198506732]


id: GO:0030074
name: obsolete thylakoid (sensu Proteobacteria)
namespace: cellular_component
def:
  "OBSOLETE. A thylakoid; as in, but not restricted to, the purple bacteria and relatives (Proteobacteria, ncbi_taxonomy_id:1224)." [GOC:mah]


id: GO:0030075
name: bacterial thylakoid
namespace: cellular_component
def:
  "A thylakoid that is derived from and attached to, but not necessarily continuous with, the plasma membrane, and is not enclosed in a plastid. It bears the photosynthetic pigments in photosynthetic cyanobacteria." [GOC:mah, GOC:mtg_sensu]


id: GO:0030076
name: light-harvesting complex
namespace: cellular_component
def:
  "A protein-pigment complex that may be closely or peripherally associated to photosynthetic reaction centers that participate in harvesting and transferring radiant energy to the reaction center." [GOC:lr]


id: GO:0030077
name: plasma membrane light-harvesting complex
namespace: cellular_component
def:
  "A plasma membrane protein-pigment complex that may be closely or peripherally associated to photosynthetic reaction centers that participate in harvesting and transferring radiant energy to the reaction center. Examples of this complex are found in bacterial species." [GOC:mah, GOC:mtg_sensu]


id: GO:0030078
name: light-harvesting complex, core complex
namespace: cellular_component
def:
  "Light harvesting complex associated with the reaction complex of photosynthetic purple bacteria." [GOC:lr]


id: GO:0030079
name: light-harvesting complex, peripheral complex
namespace: cellular_component
def:
  "Bacteriochlorophyll a binding complex that is peripherally associated to the bacterial reaction center." [GOC:lr]


id: GO:0030080
name: B875 antenna complex
namespace: cellular_component
def:
  "Protein complex that surrounds and transfers excitation energy directly to the bacterial reaction center; binds bacteriochlorophyll a and has a single absorption band between 870 and 890 nm." [GOC:kd]


id: GO:0030081
name: B800-820 antenna complex
namespace: cellular_component
def:
  "Protein-pigment complex that absorbs light at 800 and 820 nm; is peripherally associated to the bacterial reaction center; transfers excitation energy to the B875 antenna complex." [GOC:kd, GOC:lr]


id: GO:0030082
name: B800-850 antenna complex
namespace: cellular_component
def:
  "Protein-pigment complex that absorbs light at 800 and 850 nm; is peripherally associated to the bacterial reaction center; transfers excitation energy to the B875 antenna complex." [GOC:kd, GOC:lr]


id: GO:0030083
name: PSI associated light-harvesting complex I, LHCIa subcomplex
namespace: cellular_component
def:
  "A pigment protein complex that forms part of the photosystem I associated light-harvesting complex I; contains two proteins (usually about 24 and 21.5 kDa); has a fluorescence maximum between 680 and 690 nm." [PMID:8825475]


id: GO:0030084
name: PSI associated light-harvesting complex I, LHCIb subcomplex
namespace: cellular_component
def:
  "A pigment protein complex that forms part of the photosystem I associated light-harvesting complex I; contains two proteins (usually about 20 kDa); has a fluorescence maximum of 730 nm." [PMID:8825475]


id: GO:0030085
name: PSII associated light-harvesting complex II, peripheral complex, LHCIIb subcomplex
namespace: cellular_component
def:
  "A pigment protein complex that forms part of the photosystem II associated light-harvesting complex II; contains two proteins (usually about 28 and 27 kDa), and may contain a third; peripherally located relative to other LHC polypeptides." [PMID:8825475]


id: GO:0030089
name: phycobilisome
namespace: cellular_component
def:
  "Any of the granules, approximately 32 nm x 48 nm and consisting of highly aggregated phycobiliproteins, that are attached in arrays to the external face of a thylakoid membrane in algae of the phyla Cyanophyta and Rhodophyta, where they function as light-harvesting devices in photosynthesis. Excitation energy in the phycobilisome flows in the sequence: phycoerythrin, phycocyanin, allophycocyanin before passing to the antenna chlorophyll of photosystem II." [GOC:jl, PMID:11734882, Wikipedia:Phycobilisome]


id: GO:0030091
name: protein repair
namespace: biological_process
def:
  "The process of restoring a protein to its original state after damage by such things as oxidation or spontaneous decomposition of residues." [GOC:mlg]


id: GO:0030092
name: obsolete regulation of flagellum assembly
namespace: biological_process
def:
  "OBSOLETE. Any process that modulates the frequency, rate or extent of the formation of a flagellum." [GOC:go_curators]


id: GO:0030093
name: chloroplast photosystem I
namespace: cellular_component
def:
  "Photosystem located in the chloroplast that functions as a light-dependent plastocyanin-ferredoxin oxidoreductase, transferring electrons from plastocyanin to ferredoxin. An example of this is found in Arabidopsis thaliana." [GOC:jid, GOC:mtg_sensu]


id: GO:0030094
name: plasma membrane-derived photosystem I
namespace: cellular_component
def:
  "A protein complex located in the plasma membrane-derived thylakoid. The photosystem functions as a light-dependent plastocyanin-ferredoxin oxidoreductase, transferring electrons from plastocyanin to ferredoxin. Examples of this complex are found in bacterial species." [GOC:jid, GOC:mtg_sensu]


id: GO:0030095
name: chloroplast photosystem II
namespace: cellular_component
def:
  "An integral chloroplast membrane complex containing the P680 reaction center. In the light, PSII functions as a water-plastoquinone oxidoreductase, transferring electrons from water to plastoquinone." [GOC:jid, GOC:mtg_sensu]


id: GO:0030096
name: plasma membrane-derived thylakoid photosystem II
namespace: cellular_component
def:
  "A protein complex, located in the membrane-derived thylakoid, containing the P680 reaction center. In the light, PSII functions as a water-plastoquinone oxidoreductase, transferring electrons from water to plastoquinone." [GOC:jid, GOC:mtg_sensu]


id: GO:0030097
name: hemopoiesis
namespace: biological_process
def:
  "The process whose specific outcome is the progression of the myeloid and lymphoid derived organ/tissue systems of the blood and other parts of the body over time, from formation to the mature structure. The site of hemopoiesis is variable during development, but occurs primarily in bone marrow or kidney in many adult vertebrates." [GOC:dgh, ISBN:0198506732]


id: GO:0030098
name: lymphocyte differentiation
namespace: biological_process
def:
  "The process in which a relatively unspecialized precursor cell acquires specialized features of a lymphocyte. A lymphocyte is a leukocyte commonly found in the blood and lymph that has the characteristics of a large nucleus, a neutral staining cytoplasm, and prominent heterochromatin." [CL:0000542, GOC:go_curators]


id: GO:0030099
name: myeloid cell differentiation
namespace: biological_process
def:
  "The process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of any cell of the myeloid leukocyte, megakaryocyte, thrombocyte, or erythrocyte lineages." [GOC:add, ISBN:0781735149]


id: GO:0030101
name: natural killer cell activation
namespace: biological_process
def:
  "The change in morphology and behavior of a natural killer cell in response to a cytokine, chemokine, cellular ligand, or soluble factor." [GOC:mgi_curators, ISBN:0781735140]


id: GO:0030104
name: water homeostasis
namespace: biological_process
def:
  "Any process involved in the maintenance of an internal steady state of water within an organism or cell." [GOC:dph, GOC:mah, GOC:tb]


id: GO:0030105
name: obsolete anaphylaxis
namespace: biological_process
def:
  "OBSOLETE. Extreme immunological sensitivity of the body or tissues to the reintroduction of an antigen. It is a form of anamnestic reaction and is accompanied by pathological changes in tissues or organs due to the release of pharmacologically active substances." [ISBN:0198506732]


id: GO:0030106
name: obsolete MHC class I receptor activity
namespace: molecular_function
def:
  "OBSOLETE. A major histocompatibility complex class I receptor. These display processed antigens from the endocytosed bacteria. MHC class I proteins can form complexes with processed antigen peptides only if the antigen is synthesized in the same cell. As a consequence, T lymphocytes can only bind to class-I-positive cells that are synthesizing the antigen (e.g. virus-infected cells)." [ISBN:081533642X, ISBN:0879694971]


id: GO:0030107
name: HLA-A specific inhibitory MHC class I receptor activity
namespace: molecular_function
def:
  "Combining with a MHC class I molecule of the HLA-A subclass to mediate signaling that inhibits activation of a lymphocyte." [GOC:add, GOC:mah, PMID:11929129, PMID:9368779]


id: GO:0030108
name: HLA-A specific activating MHC class I receptor activity
namespace: molecular_function
def:
  "Combining with a MHC class I molecule of the HLA-A subclass to mediate signaling that activates a lymphocyte." [GOC:add, GOC:mah, PMID:11929129, PMID:9368779]


id: GO:0030109
name: HLA-B specific inhibitory MHC class I receptor activity
namespace: molecular_function
def:
  "Combining with a MHC class I molecule of the HLA-B subclass to mediate signaling that inhibits activation of a lymphocyte." [GOC:add, GOC:mah, PMID:11929129, PMID:9368779]


id: GO:0030110
name: HLA-C specific inhibitory MHC class I receptor activity
namespace: molecular_function
def:
  "Combining with a MHC class I molecule of the HLA-C subclass to mediate signaling that inhibits activation of a lymphocyte." [GOC:add, GOC:mah, PMID:11929129, PMID:9368779]


id: GO:0030111
name: regulation of Wnt signaling pathway
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of the activity of the Wnt signal transduction pathway." [GOC:dph, GOC:mah, GOC:tb]


id: GO:0030112
name: glycocalyx
namespace: cellular_component
def:
  "A viscous, carbohydrate rich layer at the outermost periphery of a cell." [GOC:mlg, ISBN:0815316208]


id: GO:0030114
name: slime layer
namespace: cellular_component
def:
  "A slime layer is an easily removed, diffuse, unorganized layer of extracellular material that surrounds a cell. Specifically this consists mostly of exopolysaccharides, glycoproteins, and glycolipids." [GOC:mlg, Wikipedia:Slime_layer]


id: GO:0030116
name: glial cell-derived neurotrophic factor receptor binding
namespace: molecular_function
def:
  "A growth factor that binds selectively and non-covalently to glial cell-derived neurotrophic factor receptors." [GOC:vw, PMID:11476867]


id: GO:0030117
name: membrane coat
namespace: cellular_component
def:
  "Any of several different proteinaceous coats that can associate with membranes. Membrane coats include those formed by clathrin plus an adaptor complex, the COPI and COPII complexes, and possibly others. They are found associated with membranes on many vesicles as well as other membrane features such as pits and perhaps tubules." [GOC:mah]


id: GO:0030118
name: clathrin coat
namespace: cellular_component
def:
  "A membrane coat found on coated pits and some coated vesicles; consists of polymerized clathrin triskelions, each comprising three clathrin heavy chains and three clathrin light chains, linked to the membrane via one of the AP adaptor complexes." [GOC:mah, PMID:11252894, PMID:9531549]


id: GO:0030119
name: AP-type membrane coat adaptor complex
namespace: cellular_component
def:
  "Any of several heterotetrameric complexes that link clathrin (or another coat-forming molecule, as hypothesized for AP-3 and AP-4) to a membrane surface; they are found on coated pits and coated vesicles, and mediate sorting of cargo proteins into vesicles. Each AP complex contains two large (a beta and one of either an alpha, gamma, delta, or epsilon) subunits (110-130 kDa), a medium (mu) subunit (approximately 50 kDa), and a small (sigma) subunit (15-20 kDa)." [GOC:mah, PMID:10611976, PMID:15473838]


id: GO:0030121
name: AP-1 adaptor complex
namespace: cellular_component
def:
  "A heterotetrameric AP-type membrane coat adaptor complex that consists of beta1, gamma, mu1 and sigma1 subunits and links clathrin to the membrane surface of a vesicle; vesicles with AP-1-containing coats are normally found primarily in the trans-Golgi network. In at least humans, the AP-1 complex can be heterogeneric due to the existence of multiple subunit isoforms encoded by different genes (gamma1 and gamma2, mu1A and mu1B, and sigma1A, sigma1B and sigma1C)." [GOC:mah, PMID:10611976, PMID:21097499]


id: GO:0030122
name: AP-2 adaptor complex
namespace: cellular_component
def:
  "A heterotetrameric AP-type membrane coat adaptor complex that consists of alpha, beta2, mu2 and sigma2 subunits, and links clathrin to the membrane surface of a vesicle; vesicles with AP-2-containing coats are normally found primarily near the plasma membrane, on endocytic vesicles. In at least humans, the AP-2 complex can be heterogeneric due to the existence of multiple subunit isoforms encoded by different alpha genes (alphaA and alphaC)." [GOC:mah, PMID:10611976, PMID:21097499]


id: GO:0030123
name: AP-3 adaptor complex
namespace: cellular_component
def:
  "A heterotetrameric AP-type membrane coat adaptor complex that consists of beta3, delta, mu3 and sigma3 subunits and is found associated with endosomal membranes. AP-3 does not appear to associate with clathrin in all organisms. In at least humans, the AP-3 complex can be heterogeneric due to the existence of multiple subunit isoforms encoded by different genes (beta3A and beta3B, mu3A and mu3B, and sigma3A and sigma3B)." [GOC:mah, PMID:10611976, PMID:21097499]


id: GO:0030124
name: AP-4 adaptor complex
namespace: cellular_component
def:
  "An AP-type membrane coat adaptor complex that consists of beta4, epsilon, mu4 and sigma4 subunits and is found associated with membranes in the trans-Golgi network; it is not clear whether AP-4 forms clathrin coats in vivo." [GOC:mah, PMID:10611976]


id: GO:0030126
name: COPI vesicle coat
namespace: cellular_component
def:
  "One of two multimeric complexes that forms a membrane vesicle coat. The mammalian COPI subunits are called alpha-, beta-, beta'-, gamma-, delta-, epsilon- and zeta-COP. Vesicles with COPI coats are found associated with Golgi membranes at steady state." [GOC:mah, PMID:11252894]


id: GO:0030127
name: COPII vesicle coat
namespace: cellular_component
def:
  "One of two multimeric complexes that forms a membrane vesicle coat. COPII is best characterized in S. cerevisiae, where the subunits are called Sar1p, Sec13p, Sec31p, Sec23p, and Sec24p. Vesicles with COPII coats are found associated with endoplasmic reticulum (ER) membranes at steady state." [GOC:ascb_2009, GOC:dph, GOC:mah, GOC:tb, PMID:11252894]


id: GO:0030132
name: clathrin coat of coated pit
namespace: cellular_component
def:
  "The coat found on coated pits and the coated vesicles derived from coated pits; comprises clathrin and the AP-2 adaptor complex." [GOC:mah]


id: GO:0030133
name: transport vesicle
namespace: cellular_component
def:
  "Any of the vesicles of the constitutive secretory pathway, which carry cargo from the endoplasmic reticulum to the Golgi, between Golgi cisternae, from the Golgi to the ER (retrograde transport) or to destinations within or outside the cell." [GOC:mah, PMID:22160157]


id: GO:0030134
name: ER to Golgi transport vesicle
namespace: cellular_component
def:
  "A vesicle that mediates transport from the endoplasmic reticulum to the Golgi complex; bears a coat formed of the COPII coat complex proteins; such vesicles found associated with endoplasmic reticulum (ER) membranes at steady state, and are involved in ER to Golgi (anterograde) vesicle transport." [GOC:ascb_2009, GOC:dph, GOC:mah, GOC:tb, PMID:11252894]


id: GO:0030135
name: coated vesicle
namespace: cellular_component
def:
  "Small membrane-bounded organelle formed by pinching off of a coated region of membrane. Some coats are made of clathrin, whereas others are made from other proteins." [ISBN:0815316194]


id: GO:0030136
name: clathrin-coated vesicle
namespace: cellular_component
def:
  "A vesicle with a coat formed of clathrin connected to the membrane via one of the clathrin adaptor complexes." [GOC:mah, PMID:11252894]


id: GO:0030137
name: COPI-coated vesicle
namespace: cellular_component
def:
  "A vesicle with a coat formed of the COPI coat complex proteins. COPI-coated vesicles are found associated with Golgi membranes at steady state, are involved in Golgi to endoplasmic reticulum (retrograde) vesicle transport, and possibly also in intra-Golgi transport." [GOC:mah, PMID:11252894]


id: GO:0030139
name: endocytic vesicle
namespace: cellular_component
def:
  "A membrane-bounded intracellular vesicle formed by invagination of the plasma membrane around an extracellular substance. Endocytic vesicles fuse with early endosomes to deliver the cargo for further sorting." [GOC:go_curators, PMID:19696797]


id: GO:0030140
name: trans-Golgi network transport vesicle
namespace: cellular_component
def:
  "A vesicle that mediates transport between the trans-Golgi network and other parts of the cell." [GOC:mah]


id: GO:0030141
name: secretory granule
namespace: cellular_component
def:
  "A small subcellular vesicle, surrounded by a membrane, that is formed from the Golgi apparatus and contains a highly concentrated protein destined for secretion. Secretory granules move towards the periphery of the cell and upon stimulation, their membranes fuse with the cell membrane, and their protein load is exteriorized. Processing of the contained protein may take place in secretory granules." [GOC:mah, ISBN:0198596732]


id: GO:0030142
name: Golgi to ER transport vesicle
namespace: cellular_component
def:
  "A vesicle that mediates transport from the Golgi to the endoplasmic reticulum." [GOC:mah, PMID:22160157]


id: GO:0030143
name: inter-Golgi transport vesicle
namespace: cellular_component
def:
  "A vesicle that mediates transport of cargo within the Golgi complex (for example, between cisternae of the Golgi stack)." [GOC:mah]


id: GO:0030144
name: alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3(6)-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl,1,6(3))-beta-D-mannosyl-1,4-N-acetyl-beta-D-glucosaminyl-R = UDP + N-acetyl-beta-D-glucosaminyl-1,2-(N-acetyl-beta-D-glucosaminyl-1,6)-1,2-alpha-D-mannosyl-1,3(6)-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6(3))-beta-D-mannosyl-1,4-N-acetyl-beta-D-glucosaminyl-R. Only branched mannose glycopeptides with non-reducing N-acetylglucosamine terminal residues act as acceptors." [EC:2.4.1.155]


id: GO:0030148
name: sphingolipid biosynthetic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid)." [GOC:mah, ISBN:0198506732]


id: GO:0030149
name: sphingolipid catabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the breakdown of sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid)." [GOC:mah, ISBN:0198506732]


id: GO:0030150
name: protein import into mitochondrial matrix
namespace: biological_process
def:
  "The import of proteins across the outer and inner mitochondrial membranes into the matrix. Unfolded proteins enter the mitochondrial matrix with a chaperone protein; the information required to target the precursor protein from the cytosol to the mitochondrial matrix is contained within its N-terminal matrix-targeting sequence. Translocation of precursors to the matrix occurs at the rare sites where the outer and inner membranes are close together." [ISBN:0716731363]


id: GO:0030152
name: bacteriocin biosynthetic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of a bacteriocin, any of a heterogeneous group of polypeptide antibiotics that are secreted by certain bacterial strains and are able to kill cells of other susceptible (frequently related) strains after adsorption at specific receptors on the cell surface. They include the colicins, and their mechanisms of action vary." [GOC:mah, ISBN:0198506732]


id: GO:0030153
name: bacteriocin immunity
namespace: biological_process
def:
  "A process that mediates resistance to a bacteriocin: any of a heterogeneous group of polypeptide antibiotics that are secreted by certain bacterial strains and are able to kill cells of other susceptible (frequently related) strains after adsorption at specific receptors on the cell surface. They include the colicins, and their mechanisms of action vary." [GOC:mah, ISBN:0198506732]


id: GO:0030154
name: cell differentiation
namespace: biological_process
def:
  "The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732]


id: GO:0030155
name: regulation of cell adhesion
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of attachment of a cell to another cell or to the extracellular matrix." [GOC:mah]


id: GO:0030156
name: benzodiazepine receptor binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with the peripheral benzodiazepine receptor (PBR)." [GOC:ceb, GOC:mah, PMID:9915832]


id: GO:0030157
name: pancreatic juice secretion
namespace: biological_process
def:
  "The regulated release of pancreatic juice by the exocrine pancreas into the upper part of the intestine. Pancreatic juice is slightly alkaline and contains numerous enzymes and inactive enzyme precursors including alpha-amylase, chymotrypsinogen, lipase, procarboxypeptidase, proelastase, prophospholipase A2, ribonuclease, and trypsinogen. Its high concentration of bicarbonate ions helps to neutralize the acid from the stomach." [GOC:mah, ISBN:0198506732]


id: GO:0030158
name: protein xylosyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the transfer of a beta-D-xylosyl residue from UDP-D-xylose to the serine hydroxyl group of an acceptor protein substrate." [EC:2.4.2.26]


id: GO:0030159
name: receptor signaling complex scaffold activity
namespace: molecular_function
def:
  "Functions to provide a physical support for the assembly of a multiprotein receptor signaling complex." [GOC:mah]


id: GO:0030160
name: GKAP/Homer scaffold activity
namespace: molecular_function
def:
  "Functions as a physical support bridging the N-methyl-D-aspartate receptor-PSD-95-GKAP complex and the mGluR-Homer complex, which are involved in receptor signaling in synapses." [PMID:10506216]


id: GO:0030161
name: obsolete calpain inhibitor activity
namespace: molecular_function
def:
  "OBSOLETE. Stops, prevents or reduces the activity of the enzyme calpain, which catalyzes of the preferential cleavage of Tyr-Xaa, Met-Xaa or Arg-Xaa with Leu or Val as the P2 residue." [GOC:ai]


id: GO:0030162
name: regulation of proteolysis
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein." [GOC:mah]


id: GO:0030163
name: protein catabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds." [GOC:mah]


id: GO:0030164
name: protein denaturation
namespace: biological_process
def:
  "Structural change in proteins which destroys the native, active configuration without rupture of peptide bonds." [GOC:kd, ISBN:3110145359]


id: GO:0030165
name: PDZ domain binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with a PDZ domain of a protein, a domain found in diverse signaling proteins." [GOC:go_curators, Pfam:PF00595]


id: GO:0030166
name: proteoglycan biosynthetic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of proteoglycans, any glycoprotein in which the carbohydrate units are glycosaminoglycans." [GOC:mah, ISBN:0198506732]


id: GO:0030167
name: proteoglycan catabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the breakdown of proteoglycans, any glycoprotein in which the carbohydrate units are glycosaminoglycans." [GOC:mah, ISBN:0198506732]


id: GO:0030168
name: platelet activation
namespace: biological_process
def:
  "A series of progressive, overlapping events triggered by exposure of the platelets to subendothelial tissue. These events include shape change, adhesiveness, aggregation, and release reactions. When carried through to completion, these events lead to the formation of a stable hemostatic plug." [http://www.graylab.ac.uk/omd/]


id: GO:0030169
name: low-density lipoprotein particle binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with a low-density lipoprotein particle, a lipoprotein particle that is rich in cholesterol esters and low in triglycerides, is typically composed of APOB100 and APOE, and has a density of 1.02-1.06 g/ml and a diameter of between 20-25 nm." [GOC:mah]


id: GO:0030170
name: pyridoxal phosphate binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732]


id: GO:0030171
name: voltage-gated proton channel activity
namespace: molecular_function
def:
  "Enables the transmembrane transfer of a proton by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [ISBN:10615049]


id: GO:0030172
name: troponin C binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with troponin C, the calcium-binding subunit of the troponin complex." [GOC:mah, ISBN:0815316194]


id: GO:0030173
name: integral component of Golgi membrane
namespace: cellular_component
def:
  "The component of the Golgi membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:go_curators]


id: GO:0030174
name: regulation of DNA-dependent DNA replication initiation
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of initiation of DNA-dependent DNA replication; the process in which DNA becomes competent to replicate. In eukaryotes, replication competence is established in early G1 and lost during the ensuing S phase." [GOC:mah]


id: GO:0030175
name: filopodium
namespace: cellular_component
def:
  "Thin, stiff, actin-based protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal or dendritic growth cone, or a dendritic shaft." [GOC:mah, GOC:pr, ISBN:0815316194]


id: GO:0030176
name: integral component of endoplasmic reticulum membrane
namespace: cellular_component
def:
  "The component of the endoplasmic reticulum membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:mah]


id: GO:0030177
name: positive regulation of Wnt signaling pathway
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of Wnt signal transduction." [GOC:dph, GOC:go_curators, GOC:tb]


id: GO:0030178
name: negative regulation of Wnt signaling pathway
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of the Wnt signaling pathway." [GOC:dph, GOC:go_curators, GOC:tb]


id: GO:0030180
name: obsolete solute:solute exchange
namespace: biological_process
def:
  "OBSOLETE. Exchange diffusion of two solutes between the inside and outside of a cell or subcellular compartment, in which movement of one solute down a concentration gradient drives movement of the other solute in the opposite direction." [GOC:mah]


id: GO:0030181
name: obsolete sodium:calcium exchange
namespace: biological_process
def:
  "OBSOLETE. Exchange diffusion sodium and calcium ions in which influx of sodium ions to the cytosol drives the efflux of calcium ions from the cell." [GOC:mah, ISBN:0198506732]


id: GO:0030182
name: neuron differentiation
namespace: biological_process
def:
  "The process in which a relatively unspecialized cell acquires specialized features of a neuron." [GOC:mah]


id: GO:0030183
name: B cell differentiation
namespace: biological_process
def:
  "The process in which a precursor cell type acquires the specialized features of a B cell. A B cell is a lymphocyte of B lineage with the phenotype CD19-positive and capable of B cell mediated immunity." [GO_REF:0000022, GOC:mah, GOC:mtg_15nov05]


id: GO:0030184
name: nitric oxide transmembrane transporter activity
namespace: molecular_function
def:
  "Enables the directed movement of nitric oxide, nitrogen monoxide, from one side of a membrane to the other." [GOC:mah]


id: GO:0030185
name: nitric oxide transport
namespace: biological_process
def:
  "The directed movement of nitric oxide, nitrogen monoxide, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah]


id: GO:0030186
name: melatonin metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving melatonin (N-acetyl-5-methoxytryptamine)." [GOC:mah, ISBN:0198506732]


id: GO:0030187
name: melatonin biosynthetic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of melatonin (N-acetyl-5-methoxytryptamine)." [GOC:mah, ISBN:0198506732]


id: GO:0030191
name: obsolete Hsp70/Hsc70 protein inhibitor activity
namespace: molecular_function
def:
  "OBSOLETE. Stops, prevents or reduces the activity of chaperones of the Hsp70/Hsc70 class." [GOC:mah]


id: GO:0030194
name: positive regulation of blood coagulation
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of blood coagulation." [GOC:mah]


id: GO:0030195
name: negative regulation of blood coagulation
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of blood coagulation." [GOC:mah]


id: GO:0030198
name: extracellular matrix organization
namespace: biological_process
def:
  "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an extracellular matrix." [GOC:mah]


id: GO:0030199
name: collagen fibril organization
namespace: biological_process
def:
  "Any process that determines the size and arrangement of collagen fibrils within an extracellular matrix." [GOC:mah, ISBN:0815316194]


id: GO:0030200
name: heparan sulfate proteoglycan catabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the breakdown of proteoglycan containing heparan sulfate, any member of a group of glycosaminoglycans that have repeat units consisting of alternating alpha-(1->4) linked hexuronic acid and glucosamine residues, the former being a mixture of sulfated and nonsulfated D-glucuronic and L-iduronic acids, and the latter being either sulfated or acetylated on its amino group as well as sulfated on one of its hydroxyl groups." [GOC:mah, ISBN:0198506732]


id: GO:0030201
name: heparan sulfate proteoglycan metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving any proteoglycan containing heparan sulfate, any member of a group of glycosaminoglycans that have repeat units consisting of alternating alpha-(1->4)-linked hexuronic acid and glucosamine residues, the former being a mixture of sulfated and nonsulfated D-glucuronic and L-iduronic acids, and the latter being either sulfated or acetylated on its amino group as well as sulfated on one of its hydroxyl groups." [GOC:mah, ISBN:0198506732]


id: GO:0030202
name: heparin metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving heparin, any member of a group of glycosaminoglycans found mainly as an intracellular component of mast cells. They are similar to heparan sulfates but are of somewhat higher average Mr (6000-20000) and contain fewer N-acetyl groups and more N-sulfate and O-sulfate groups; they may be attached in the same manner to protein, forming proteoglycans. They consist predominantly of alternating alpha-(1->4)-linked D-galactose and N-acetyl-D-glucosamine-6-sulfate residues." [GOC:mah, ISBN:0198506732]


id: GO:0030203
name: glycosaminoglycan metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving glycosaminoglycans, any one of a group of polysaccharides that contain amino sugars. Formerly known as mucopolysaccharides, they include hyaluronic acid and chondroitin, which provide lubrication in joints and form part of the matrix of cartilage. The three-dimensional structure of these molecules enables them to trap water, which forms a gel and gives glycosaminoglycans their elastic properties." [ISBN:0192800981]


id: GO:0030204
name: chondroitin sulfate metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving chondroitin sulfate, any member of a group of 10-60 kDa glycosaminoglycans, widely distributed in cartilage and other mammalian connective tissues, the repeat units of which consist of beta-(1,4)-linked D-glucuronyl beta-(1,3)-N-acetyl-D-galactosamine sulfate. They usually occur linked to a protein to form proteoglycans. Two subgroups exist, one in which the sulfate is on the 4-position (chondroitin sulfate A) and the second in which it is in the 6-position (chondroitin sulfate C). They often are polydisperse and often differ in the degree of sulfation from tissue to tissue. The chains of repeating disaccharide are covalently linked to the side chains of serine residues in the polypeptide backbone of a protein by a glycosidic attachment through the trisaccharide unit galactosyl-galactosyl-xylosyl. Chondroitin sulfate B is more usually known as dermatan sulfate." [GOC:mah, ISBN:0198506732]


id: GO:0030205
name: dermatan sulfate metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving dermatan sulfate, any of a group of glycosaminoglycans with repeats consisting of beta-(1,4)-linked L-iduronyl-beta-(1,3)-N-acetyl-D-galactosamine 4-sulfate units. They are important components of ground substance or intercellular cement of skin and some connective tissues." [GOC:mah, ISBN:0198506732]


id: GO:0030206
name: chondroitin sulfate biosynthetic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of chondroitin sulfate, any member of a group of 10-60 kDa glycosaminoglycans, widely distributed in cartilage and other mammalian connective tissues, the repeat units of which consist of beta-(1,4)-linked D-glucuronyl beta-(1,3)-N-acetyl-D-galactosamine sulfate." [GOC:mah, ISBN:0198506732]


id: GO:0030207
name: chondroitin sulfate catabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the breakdown of chondroitin sulfate, any member of a group of 10-60 kDa glycosaminoglycans, widely distributed in cartilage and other mammalian connective tissues, the repeat units of which consist of beta-(1,4)-linked D-glucuronyl beta-(1,3)-N-acetyl-D-galactosamine sulfate." [GOC:mah, ISBN:0198506732]


id: GO:0030208
name: dermatan sulfate biosynthetic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of dermatan sulfate, any glycosaminoglycan with repeats consisting of beta-(1,4)-linked L-iduronyl-beta-(1,3)-N-acetyl-D-galactosamine 4-sulfate units." [GOC:mah, ISBN:0198506732]


id: GO:0030209
name: dermatan sulfate catabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the breakdown of dermatan sulfate, any of a group of glycosaminoglycans with repeats consisting of beta-(1,4)-linked L-iduronyl-beta-(1,3)-N-acetyl-D-galactosamine 4-sulfate units." [GOC:mah, ISBN:0198506732]


id: GO:0030210
name: heparin biosynthetic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of heparin, any member of a group of glycosaminoglycans of average Mr (6000-20000), consisting predominantly of alternating alpha-(1->4)-linked D-galactose and N-acetyl-D-glucosamine-6-sulfate residues." [GOC:mah, ISBN:0198506732]


id: GO:0030211
name: heparin catabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the breakdown of heparin, any member of a group of glycosaminoglycans of average Mr (6000-20000), consisting predominantly of alternating alpha-(1->4)-linked D-galactose and N-acetyl-D-glucosamine-6-sulfate residues." [GOC:mah, ISBN:0198506732]


id: GO:0030212
name: hyaluronan metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving hyaluronan, the naturally occurring anionic form of hyaluronic acid, any member of a group of glycosaminoglycans, the repeat units of which consist of beta-1,4 linked D-glucuronyl-beta-(1,3)-N-acetyl-D-glucosamine." [GOC:mah, ISBN:0198506732]


id: GO:0030213
name: hyaluronan biosynthetic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of hyaluronan, the naturally occurring anionic form of hyaluronic acid, any member of a group of glycosaminoglycans, the repeat units of which consist of beta-1,4 linked D-glucuronyl-beta-(1,3)-N-acetyl-D-glucosamine." [GOC:mah, ISBN:0198506732]


id: GO:0030214
name: hyaluronan catabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the breakdown of hyaluronan, the naturally occurring anionic form of hyaluronic acid, any member of a group of glycosaminoglycans, the repeat units of which consist of beta-1,4 linked D-glucuronyl-beta-(1,3)-N-acetyl-D-glucosamine." [GOC:mah, ISBN:0198506732]


id: GO:0030216
name: keratinocyte differentiation
namespace: biological_process
def:
  "The process in which a relatively unspecialized cell acquires specialized features of a keratinocyte." [GOC:dph, GOC:mah, GOC:sdb_2009, GOC:tb]


id: GO:0030217
name: T cell differentiation
namespace: biological_process
def:
  "The process in which a precursor cell type acquires characteristics of a more mature T-cell. A T cell is a type of lymphocyte whose definin characteristic is the expression of a T cell receptor complex." [GO_REF:0000022, GOC:jid, GOC:mah, GOC:mtg_15nov05]


id: GO:0030218
name: erythrocyte differentiation
namespace: biological_process
def:
  "The process in which a myeloid precursor cell acquires specializes features of an erythrocyte." [GOC:mah]


id: GO:0030219
name: megakaryocyte differentiation
namespace: biological_process
def:
  "The process in which a myeloid precursor cell acquires specializes features of a megakaryocyte." [GOC:mah]


id: GO:0030220
name: platelet formation
namespace: biological_process
def:
  "The process in which platelets bud from long processes extended by megakaryocytes." [GOC:mah, ISBN:0815316194]


id: GO:0030221
name: basophil differentiation
namespace: biological_process
def:
  "The process in which a relatively unspecialized myeloid precursor cell acquires specialized features of a basophil cell." [GOC:jid, GOC:mah]


id: GO:0030222
name: eosinophil differentiation
namespace: biological_process
def:
  "The process in which a relatively unspecialized myeloid precursor cell acquires the specializes features of an eosinophil." [GOC:add, GOC:mah]


id: GO:0030223
name: neutrophil differentiation
namespace: biological_process
def:
  "The process in which a myeloid precursor cell acquires the specialized features of a neutrophil." [GOC:mah]


id: GO:0030224
name: monocyte differentiation
namespace: biological_process
def:
  "The process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of a monocyte." [GOC:mah]


id: GO:0030225
name: macrophage differentiation
namespace: biological_process
def:
  "The process in which a relatively unspecialized monocyte acquires the specialized features of a macrophage." [GOC:add, ISBN:0781735149]


id: GO:0030226
name: apolipoprotein receptor activity
namespace: molecular_function
def:
  "Combining with an apolipoprotein to initiate a change in cell activity." [GOC:mah, ISBN:0198506732]


id: GO:0030228
name: lipoprotein particle receptor activity
namespace: molecular_function
def:
  "Combining with a lipoprotein particle and delivering the lipoprotein particle into the cell via endocytosis. A lipoprotein particle, also known as a lipoprotein, is a clathrate complex consisting of a lipid enwrapped in a protein host without covalent binding in such a way that the complex has a hydrophilic outer surface consisting of all the protein and the polar ends of any phospholipids." [CHEBI:6495, GOC:bf, GOC:mah, PMID:12827279]


id: GO:0030229
name: very-low-density lipoprotein particle receptor activity
namespace: molecular_function
def:
  "Combining with a very-low-density lipoprotein particle and delivering the very-low-density lipoprotein into the cell via endocytosis." [GOC:bf, ISBN:0198506732]


id: GO:0030232
name: insulin control element activator complex
namespace: cellular_component
def:
  "Transcription factor complex that binds to the insulin control element (ICE), a DNA sequence element found within the 5'-flanking region of the insulin gene, and activates ICE-mediated transcription." [PMID:7935390]


id: GO:0030233
name: deoxynucleotide transmembrane transporter activity
namespace: molecular_function
def:
  "Catalyzes transport of all four deoxy (d) NDPs, and, less efficiently, the corresponding dNTPs, in exchange for dNDPs, ADP, or ATP." [PMID:11226231]


id: GO:0030240
name: skeletal muscle thin filament assembly
namespace: biological_process
def:
  "The aggregation, arrangement and bonding together of proteins to form the actin-based thin filaments of myofibrils in skeletal muscle." [GOC:ef, GOC:mah, GOC:mtg_muscle]


id: GO:0030241
name: skeletal muscle myosin thick filament assembly
namespace: biological_process
def:
  "The aggregation, arrangement and bonding together of proteins to form the myosin-based thick filaments of myofibrils in skeletal muscle." [GOC:ef, GOC:mah, GOC:mtg_muscle]


id: GO:0030242
name: pexophagy
namespace: biological_process
def:
  "The process in which peroxisomes are delivered to the vacuole and degraded in response to changing nutrient conditions." [GOC:autophagy, PMID:10547367, PMID:20083110]


id: GO:0030243
name: cellulose metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving cellulose, a linear beta1-4 glucan of molecular mass 50-400 kDa with the pyranose units in the -4C1 conformation." [GOC:mah, ISBN:0198506732]


id: GO:0030244
name: cellulose biosynthetic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of cellulose, a linear beta1-4 glucan of molecular mass 50-400 kDa with the pyranose units in the -4C1 conformation." [GOC:mah, ISBN:0198506732]


id: GO:0030245
name: cellulose catabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the breakdown of cellulose, a linear beta1-4 glucan of molecular mass 50-400 kDa with the pyranose units in the -4C1 conformation." [GOC:mah, ISBN:0198506732]


id: GO:0030246
name: carbohydrate binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with any carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [CHEBI:16646, GOC:mah]


id: GO:0030247
name: polysaccharide binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with any polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically." [CHEBI:18154, GOC:mah]


id: GO:0030253
name: protein secretion by the type I secretion system
namespace: biological_process
def:
  "The process in which proteins are secreted into the extracellular milieu via the type I secretion system; secretion occurs in a continuous process without the distinct presence of periplasmic intermediates and does not involve proteolytic processing of secreted proteins." [GOC:pamgo_curators]


id: GO:0030254
name: protein secretion by the type III secretion system
namespace: biological_process
def:
  "The process in which proteins are transferred into the extracellular milieu or directly into host cells by the bacterial type III secretion system; secretion occurs in a continuous process without the distinct presence of periplasmic intermediates and does not involve proteolytic processing of secreted proteins." [GOC:pamgo_curators]


id: GO:0030255
name: protein secretion by the type IV secretion system
namespace: biological_process
def:
  "The process in which proteins are transferred into the extracellular milieu or directly into host cells, via the type IV protein secretion system." [GOC:pamgo_curators]


id: GO:0030256
name: type I protein secretion system complex
namespace: cellular_component
def:
  "A complex of three secretory proteins that carry out secretion in the type I secretion system: an inner membrane transport ATPase (termed ABC protein for ATP-binding cassette), which provides the energy for protein secretion; an outer membrane protein, which is exported via the sec pathway; and a membrane fusion protein, which is anchored in the inner membrane and spans the periplasmic space." [PMID:9618447]


id: GO:0030257
name: type III protein secretion system complex
namespace: cellular_component
def:
  "A complex of approximately 20 proteins, most of which are located in the cytoplasmic membrane that carries out protein secretion in the bacterial type III secretion system; type III secretion also requires a cytoplasmic, probably membrane-associated ATPase." [PMID:9618447]


id: GO:0030258
name: lipid modification
namespace: biological_process
def:
  "The covalent alteration of one or more fatty acids in a lipid, resulting in a change in the properties of the lipid." [GOC:mah]


id: GO:0030260
name: entry into host cell
namespace: biological_process
def:
  "The invasion by an organism of a cell of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:njm]


id: GO:0030261
name: chromosome condensation
namespace: biological_process
def:
  "The progressive compaction of dispersed interphase chromatin into threadlike chromosomes prior to mitotic or meiotic nuclear division, or during apoptosis, in eukaryotic cells." [GOC:mah, ISBN:0815316194]


id: GO:0030262
name: apoptotic nuclear changes
namespace: biological_process
def:
  "Alterations undergone by nuclei at the molecular and morphological level as part of the execution phase of apoptosis." [GOC:mah, GOC:mtg_apoptosis]


id: GO:0030264
name: nuclear fragmentation involved in apoptotic nuclear change
namespace: biological_process
def:
  "The breakdown of the nucleus into small membrane-bounded compartments, or blebs, each of which contain compacted DNA." [GOC:dph, GOC:mah, GOC:mtg_apoptosis, GOC:tb, ISBN:0721639976]


id: GO:0030265
name: phospholipase C-activating rhodopsin mediated signaling pathway
namespace: biological_process
def:
  "The series of molecular signals generated as a consequence of a rhodopsin molecule being activated by a photon, where the pathway proceeds with activation of phospholipase C (PLC) and a subsequent release of inositol trisphosphate (IP3) and diacylglycerol (DAG)." [GOC:mah, GOC:signaling, PMID:22498302, PMID:8823931]


id: GO:0030268
name: methylenetetrahydromethanopterin dehydrogenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 5,10-methylenetetrahydromethanopterin + coenzyme F420 + 2 H(+) = 5,10-methenyl-5,6,7,8-tetrahydromethanopterin + reduced coenzyme F420." [EC:1.5.99.9, RHEA:16724]


id: GO:0030269
name: tetrahydromethanopterin S-methyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 5-methyltetrahydromethanopterin + coenzyme M = 5,6,7,8-tetrahydromethanopterin + methyl-coenzyme M. 2-(methylthio)ethanesulfonate is also known as methyl-CoM." [EC:2.1.1.86, RHEA:17588]


id: GO:0030270
name: formylmethanofuran-tetrahydromethanopterin N-formyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 5,6,7,8-tetrahydromethanopterin + N-formylmethanofuran + H(+) = N(5)-formyl-5,6,7,8-tetrahydromethanopterin + methanofuran." [EC:2.3.1.101, RHEA:18064]


id: GO:0030271
name: obsolete chymase activity
namespace: molecular_function
def:
  "OBSOLETE. Catalysis of the preferential cleavage: Phe-Xaa > Tyr-Xaa > Trp-Xaa > Leu-Xaa." [EC:3.4.21.39]


id: GO:0030272
name: 5-formyltetrahydrofolate cyclo-ligase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 5-formyltetrahydrofolate + ATP = 5,10-methenyltetrahydrofolate + ADP + H(+) + phosphate." [EC:6.3.3.2, RHEA:10491]


id: GO:0030273
name: melanin-concentrating hormone receptor activity
namespace: molecular_function
def:
  "Combining with the cyclic peptide hormone melanin-concentrating hormone to initiate a change in cell activity." [GOC:mah]


id: GO:0030274
name: LIM domain binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with a LIM domain (for Lin-11 Isl-1 Mec-3) of a protein, a domain with seven conserved cysteine residues and a histidine, that binds two zinc ions and acts as an interface for protein-protein interactions." [GOC:go_curators, Pfam:PF00412]


id: GO:0030275
name: LRR domain binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with a LRR domain (leucine rich repeats) of a protein." [GOC:go_curators, Pfam:PF00560]


id: GO:0030276
name: clathrin binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with a clathrin heavy or light chain, the main components of the coat of coated vesicles and coated pits, and which also occurs in synaptic vesicles." [GOC:jl, GOC:mah, ISBN:0198506732]


id: GO:0030277
name: maintenance of gastrointestinal epithelium
namespace: biological_process
def:
  "Protection of epithelial surfaces of the gastrointestinal tract from proteolytic and caustic digestive agents." [GOC:mah]


id: GO:0030279
name: negative regulation of ossification
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of bone formation." [GOC:go_curators]


id: GO:0030280
name: structural constituent of epidermis
namespace: molecular_function
def:
  "The action of a molecule that contributes to the structural integrity of an epidermal cutaneous structure." [GOC:mah]


id: GO:0030281
name: structural constituent of cutaneous appendage
namespace: molecular_function
def:
  "The action of a molecule that contributes to the structural integrity of cutaneous epidermal structures such as hairs, scales, or feathers." [GOC:mah, ISBN:0878932437]


id: GO:0030282
name: bone mineralization
namespace: biological_process
def:
  "The deposition of hydroxyapatite, a form of calcium phosphate with the formula Ca10(PO4)6(OH)2, in bone tissue." [GOC:mah, PMID:22936354]


id: GO:0030283
name: testosterone dehydrogenase [NAD(P)] activity
namespace: molecular_function
def:
  "Catalysis of the reaction: testosterone + NAD(P)+ = androst-4-ene-3,17-dione + NAD(P)H + H+." [EC:1.1.1.51]


id: GO:0030284
name: estrogen receptor activity
namespace: molecular_function
def:
  "Combining with estrogen and transmitting the signal within the cell to trigger a change in cell activity or function." [GOC:signaling, PMID:17615392]


id: GO:0030285
name: integral component of synaptic vesicle membrane
namespace: cellular_component
def:
  "The component of the synaptic vesicle membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators]


id: GO:0030286
name: dynein complex
namespace: cellular_component
def:
  "Any of several large complexes that contain two or three dynein heavy chains and several light chains, and have microtubule motor activity." [ISBN:0815316194]


id: GO:0030287
name: cell wall-bounded periplasmic space
namespace: cellular_component
def:
  "The region between the plasma membrane and the cell wall in organisms lacking an outer cell membrane such as yeast and Gram positive bacteria. The region is thinner than the equivalent in Gram negative bacteria." [GOC:mlg, GOC:mtg_sensu]


id: GO:0030288
name: outer membrane-bounded periplasmic space
namespace: cellular_component
def:
  "The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall." [GOC:mlg, GOC:mtg_sensu]


id: GO:0030289
name: protein phosphatase 4 complex
namespace: cellular_component
def:
  "A protein serine/threonine phosphatase complex formed by the catalytic subunit of protein phosphatase 4 plus one or more regulatory subunits." [GOC:bm, PMID:10026142]


id: GO:0030290
name: sphingolipid activator protein activity
namespace: molecular_function
def:
  "Any of a group of peptide cofactors of enzymes for the lysosomal degradation of sphingolipids. They stimulate various enzymes, including glucosylceramidase, galactosylceramidase, cerebroside-sulfatase, alpha-galactosidase, beta-galactosidase, and sphingomyelin phosphodiesterase." [ISBN:0198506732]


id: GO:0030293
name: transmembrane receptor protein tyrosine kinase inhibitor activity
namespace: molecular_function
def:
  "Stops, prevents or reduces the activity of a transmembrane receptor protein tyrosine kinase." [GOC:mah]


id: GO:0030294
name: receptor signaling protein tyrosine kinase inhibitor activity
namespace: molecular_function
def:
  "Stops, prevents or reduces the activity of a receptor signaling protein tyrosine kinase." [GOC:mah]


id: GO:0030295
name: protein kinase activator activity
namespace: molecular_function
def:
  "Binds to and increases the activity of a protein kinase, an enzyme which phosphorylates a protein." [GOC:ai]


id: GO:0030296
name: protein tyrosine kinase activator activity
namespace: molecular_function
def:
  "Increases the activity of a protein tyrosine kinase, an enzyme which phosphorylates a tyrosyl phenolic group on a protein." [GOC:ai, ISBN:0198506732]


id: GO:0030297
name: transmembrane receptor protein tyrosine kinase activator activity
namespace: molecular_function
def:
  "Binds to and increases the activity of a transmembrane receptor protein tyrosine kinase." [GOC:mah]


id: GO:0030300
name: regulation of intestinal cholesterol absorption
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of absorption of cholesterol into the blood, and the exclusion of other sterols from absorption." [GOC:mah, PMID:11099417]


id: GO:0030301
name: cholesterol transport
namespace: biological_process
def:
  "The directed movement of cholesterol, cholest-5-en-3-beta-ol, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah, ISBN:0198506732]


id: GO:0030302
name: deoxynucleotide transport
namespace: biological_process
def:
  "The directed movement of a deoxynucleotide, a deoxyribonucleoside in ester linkage to phosphate, commonly at the 5' position of deoxyribose, into, out of or within a cell." [GOC:mah, ISBN:0198506732]


id: GO:0030303
name: obsolete stromelysin 2 activity
namespace: molecular_function
def:
  "OBSOLETE. Catalysis of the cleavage of peptide bonds in collagen with preferential cleavage where P1', P2' and P3' are hydrophobic residues; action on collagen types III, IV and V is weak." [EC:3.4.24.17, EC:3.4.24.22]


id: GO:0030305
name: heparanase activity
namespace: molecular_function
def:
  "Catalysis of the cleavage of heparan sulfate; can degrade both heparan sulfate and heparin glycosaminoglycan chains." [PMID:10916150]


id: GO:0030306
name: ADP-ribosylation factor binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with ARF, ADP-ribosylation factor, a small monomeric cytosolic GTPase that, when bound to GTP, binds to the membranes of cells." [ISBN:0198506732]


id: GO:0030307
name: positive regulation of cell growth
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate, extent or direction of cell growth." [GOC:go_curators]


id: GO:0030308
name: negative regulation of cell growth
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate, extent or direction of cell growth." [GOC:go_curators]


id: GO:0030309
name: poly-N-acetyllactosamine metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving poly-N-acetyllactosamine, a carbohydrate composed of N-acetyllactosamine repeats (Gal-beta-1,4-GlcNAc-beta-1,3)n." [GOC:mah, PMID:9405606]


id: GO:0030310
name: poly-N-acetyllactosamine catabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the breakdown of poly-N-acetyllactosamine, a carbohydrate composed of N-acetyllactosamine repeats (Gal-beta-1,4-GlcNAc-beta-1,3)n." [GOC:mah, PMID:9405606]


id: GO:0030311
name: poly-N-acetyllactosamine biosynthetic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of poly-N-acetyllactosamine, a carbohydrate composed of N-acetyllactosamine repeats (Gal-beta-1,4-GlcNAc-beta-1,3)n." [GOC:mah, PMID:9405606]


id: GO:0030312
name: external encapsulating structure
namespace: cellular_component
def:
  "A structure that lies outside the plasma membrane and surrounds the entire cell. This does not include the periplasmic space." [GOC:go_curators]


id: GO:0030313
name: cell envelope
namespace: cellular_component
def:
  "An envelope that surrounds a bacterial cell and includes the cytoplasmic membrane and everything external, encompassing the periplasmic space, cell wall, and outer membrane if present." [GOC:ds, GOC:mlg, http://pathmicro.med.sc.edu/fox/cell_envelope.htm]


id: GO:0030314
name: junctional membrane complex
namespace: cellular_component
def:
  "Complex formed in muscle cells between the membrane of the sarcoplasmic reticulum and invaginations of the plasma membrane (T-tubules)." [PMID:11535622]


id: GO:0030315
name: T-tubule
namespace: cellular_component
def:
  "Invagination of the plasma membrane of a muscle cell that extends inward from the cell surface around each myofibril. The ends of T-tubules make contact with the sarcoplasmic reticulum membrane." [GOC:mtg_muscle, ISBN:0815316194]


id: GO:0030316
name: osteoclast differentiation
namespace: biological_process
def:
  "The process in which a relatively unspecialized monocyte acquires the specialized features of an osteoclast. An osteoclast is a specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue." [CL:0000092, GOC:add, ISBN:0781735149, PMID:12161749]


id: GO:0030318
name: melanocyte differentiation
namespace: biological_process
def:
  "The process in which a relatively unspecialized cell acquires specialized features of a melanocyte." [GOC:mah]


id: GO:0030319
name: obsolete cellular di-, tri-valent inorganic anion homeostasis
namespace: biological_process
def:
  "OBSOLETE. Any process involved in the maintenance of an internal steady state of divalent or trivalent inorganic anions at the level of a cell." [GOC:ai, GOC:mah]


id: GO:0030320
name: cellular monovalent inorganic anion homeostasis
namespace: biological_process
def:
  "Any process involved in the maintenance of an internal steady state of monovalent inorganic anions at the level of a cell." [GOC:ai, GOC:mah]


id: GO:0030322
name: stabilization of membrane potential
namespace: biological_process
def:
  "The accomplishment of a non-fluctuating membrane potential, the electric potential existing across any membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane." [GOC:jl, ISBN:0198506732]


id: GO:0030323
name: respiratory tube development
namespace: biological_process
def:
  "The process whose specific outcome is the progression of the respiratory tube over time, from its formation to the mature structure. The respiratory tube is assumed to mean any tube in the respiratory tract." [GOC:jid]


id: GO:0030324
name: lung development
namespace: biological_process
def:
  "The process whose specific outcome is the progression of the lung over time, from its formation to the mature structure. In all air-breathing vertebrates the lungs are developed from the ventral wall of the oesophagus as a pouch which divides into two sacs. In amphibians and many reptiles the lungs retain very nearly this primitive sac-like character, but in the higher forms the connection with the esophagus becomes elongated into the windpipe and the inner walls of the sacs become more and more divided, until, in the mammals, the air spaces become minutely divided into tubes ending in small air cells, in the walls of which the blood circulates in a fine network of capillaries. In mammals the lungs are more or less divided into lobes, and each lung occupies a separate cavity in the thorax." [GOC:jid, UBERON:0002048]


id: GO:0030325
name: adrenal gland development
namespace: biological_process
def:
  "The process whose specific outcome is the progression of the adrenal gland over time, from its formation to the mature structure. This gland can either be a discrete structure located bilaterally above each kidney, or a cluster of cells in the head kidney that perform the functions of the adrenal gland. In either case, this organ consists of two cells types, aminergic chromaffin cells and steroidogenic cortical cells." [GOC:dgh]


id: GO:0030326
name: embryonic limb morphogenesis
namespace: biological_process
def:
  "The process, occurring in the embryo, by which the anatomical structures of the limb are generated and organized. A limb is an appendage of an animal used for locomotion or grasping." [GOC:bf, GOC:jl, ISBN:0395825172]


id: GO:0030328
name: prenylcysteine catabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the breakdown of prenylcysteine, 3-methyl-2-buten-1-yl-cysteine, a derivative of the amino acid cysteine formed by the covalent addition of a prenyl residue." [GOC:ai]


id: GO:0030329
name: prenylcysteine metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving prenylcysteine, 3-methyl-2-buten-1-yl-cysteine, a derivative of the amino acid cysteine formed by the covalent addition of a prenyl residue." [GOC:ai, PMID:16627894]


id: GO:0030330
name: DNA damage response, signal transduction by p53 class mediator
namespace: biological_process
def:
  "A cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage." [GOC:go_curators]


id: GO:0030332
name: cyclin binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with cyclins, proteins whose levels in a cell varies markedly during the cell cycle, rising steadily until mitosis, then falling abruptly to zero. As cyclins reach a threshold level, they are thought to drive cells into G2 phase and thus to mitosis." [GOC:ai]


id: GO:0030335
name: positive regulation of cell migration
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of cell migration." [GOC:go_curators]


id: GO:0030336
name: negative regulation of cell migration
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of cell migration." [GOC:go_curators]


id: GO:0030337
name: DNA polymerase processivity factor activity
namespace: molecular_function
def:
  "An enzyme regulator activity that increases the processivity of polymerization by DNA polymerase, by allowing the polymerase to move rapidly along DNA while remaining topologically bound to it." [GOC:mah, PMID:7903401, PMID:8087839]


id: GO:0030338
name: CMP-N-acetylneuraminate monooxygenase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: CMP-N-acetylneuraminate + NADPH + H+ + O2 = CMP-N-glycoloylneuraminate + NADP+ + H2O." [EC:1.14.18.2]


id: GO:0030339
name: fatty-acyl-ethyl-ester synthase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: a long-chain-acyl ethyl ester + H2O = a long-chain carboxylic acid + ethanol." [EC:3.1.1.67]


id: GO:0030340
name: hyaluronate lyase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: hyaluronate = n 3-(4-deoxy-beta-D-gluc-4-enuronosyl)-N-acetyl-D-glucosamine." [EC:4.2.2.1]


id: GO:0030341
name: chondroitin AC lyase activity
namespace: molecular_function
def:
  "Catalysis of the eliminative degradation of polysaccharides containing 1,4-beta-D-hexosaminyl and 1,3-beta-D-glucuronosyl linkages to disaccharides containing 4-deoxy-beta-D-gluc-4-enuronosyl groups." [EC:4.2.2.5]


id: GO:0030342
name: 1-alpha,25-dihydroxyvitamin D3 24-hydroxylase activity
namespace: molecular_function
def:
  "Catalysis of the hydroxylation of C-24 of 1-alpha,25-hydroxycholecalciferol (25-hydroxyvitamin D3; calcitriol)." [PMID:8506296]


id: GO:0030343
name: vitamin D3 25-hydroxylase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: vitamin D3 + NADPH + H+ + O2 = calcidiol + NADP+ + H2O." [ISBN:0471331309, MetaCyc:RXN-9829]


id: GO:0030350
name: iron-responsive element binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with the iron-responsive element, a regulatory sequence found in the 5'- and 3'-untranslated regions of mRNAs encoding many iron-binding proteins." [PMID:3198610, PMID:8710843]


id: GO:0030351
name: inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: inositol-1,3,4,5,6-pentakisphosphate + H2O = inositol-1,4,5,6-tetrakisphosphate + phosphate." [GOC:ai]


id: GO:0030352
name: inositol-1,4,5,6-tetrakisphosphate 6-phosphatase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: inositol-1,4,5,6-tetrakisphosphate + H2O = inositol-1,4,5-trisphosphate + phosphate." [GOC:ai]


id: GO:0030353
name: fibroblast growth factor receptor antagonist activity
namespace: molecular_function
def:
  "Interacts with the fibroblast growth factor receptor to reduce the action of another ligand, the agonist." [GOC:mah]


id: GO:0030354
name: melanin-concentrating hormone activity
namespace: molecular_function
def:
  "The action characteristic of melanin-concentrating hormone, a cyclic peptide hormone that, upon receptor binding, induces melanin aggregation in melanocytes, and is also involved in regulating food intake and energy balance in mammals." [GOC:mah, PMID:11416225, PMID:9792536]


id: GO:0030364
name: obsolete cleavage and polyadenylylation specificity factor activity
namespace: molecular_function
def:
  "OBSOLETE. A factor required in mRNA 3' end processing for both the cleavage and poly(A) addition reactions and, consistent with this function, recognizes AAUAAA, a signal also essential for both reactions." [PMID:10357856]


id: GO:0030365
name: obsolete cleavage stimulation factor activity
namespace: molecular_function
def:
  "OBSOLETE. A factor is necessary for cleavage but not for poly(A) addition in mRNA 3' end processing; can stimulate poly(A) addition on substrates with a CstF binding site upstream of the AAUAAA hexanucleotide." [PMID:10357856]


id: GO:0030366
name: molybdopterin synthase activity
namespace: molecular_function
def:
  "Catalysis of the conversion of precursor Z to molybdopterin, the final step in molybdopterin biosynthesis." [PMID:18154309, PMID:8514783]


id: GO:0030368
name: interleukin-17 receptor activity
namespace: molecular_function
def:
  "Combining with any member of the interleukin-17 family of cytokines and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:add, GOC:jl, GOC:signaling]


id: GO:0030369
name: ICAM-3 receptor activity
namespace: molecular_function
def:
  "Combining with ICAM-3, intercellular adhesion molecule 3, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. ICAM-3, or CD50, are constitutively expressed on monocytes, granulocytes and lymphocytes; on physiological stimulation, they become transiently phosphorylated on serine residues." [GOC:ai, GOC:signaling, ISBN:0198506732, PMID:7515813]


id: GO:0030370
name: intercellular adhesion molecule-3 receptor binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with receptors for intercellular adhesion molecule-3 (ICAM-3), such as DC-SIGN and LFA-1." [GOC:ceb, PMID:11473836]


id: GO:0030372
name: high molecular weight B cell growth factor receptor binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with the high molecular weight B cell growth factor receptor." [GOC:ai]


id: GO:0030373
name: high molecular weight B cell growth factor receptor activity
namespace: molecular_function
def:
  "Combining with a high molecular weight B cell growth factor and transmitting the signal to initiate a change in cell activity." [GOC:ai, GOC:signaling, PMID:2681271]


id: GO:0030374
name: ligand-dependent nuclear receptor transcription coactivator activity
namespace: molecular_function
def:
  "The function of a transcription cofactor that activates transcription in conjuction with a ligand-dependent nuclear receptor from a RNA polymerase II promoter; does not bind DNA itself." [GOC:dph, GOC:tb]


id: GO:0030375
name: thyroid hormone receptor coactivator activity
namespace: molecular_function
def:
  "The function of a transcription cofactor that activates transcription in conjunction with a thyroid hormone-dependent nuclear receptor from a RNA polymerase II promoter; does not bind DNA itself." [GOC:dph, GOC:tb]


id: GO:0030377
name: urokinase plasminogen activator receptor activity
namespace: molecular_function
def:
  "Combining with the urokinase plasminogen activator to initiate a change in cell activity." [GOC:mah, PMID:16456079]


id: GO:0030379
name: neurotensin receptor activity, non-G-protein coupled
namespace: molecular_function
def:
  "Combining with neurotensin, a neuropeptide active in the central and peripheral nervous system in mammals, and transmitting the signal from one side of the membrane to the other by a mechanism independent of coupling to G proteins." [GOC:mah, GOC:signaling, PMID:9756851]


id: GO:0030381
name: chorion-containing eggshell pattern formation
namespace: biological_process
def:
  "The regionalization process that gives rise to the structural pattern of a chorion-containing eggshell such as those found in insects." [GOC:bf, GOC:mtg_sensu]


id: GO:0030382
name: sperm mitochondrion organization
namespace: biological_process
def:
  "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of sperm mitochondria; the process in which they take on their characteristic morphology; they are flattened, elongated, and arranged circumferentially into a tight helical coil around the tail-dense fibers of the mature sperm." [GOC:dph, GOC:jl, GOC:mah, PMID:8833144]


id: GO:0030385
name: ferredoxin:thioredoxin reductase activity
namespace: molecular_function
def:
  "Catalysis of the two-electron reduction of the disulfide of thioredoxins with electrons from ferredoxin involving a 4Fe-4S cluster and an adjacent active-site disulfide." [PMID:14769790]


id: GO:0030388
name: fructose 1,6-bisphosphate metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving fructose 1,6-bisphosphate, also known as FBP. The D enantiomer is a metabolic intermediate in glycolysis and gluconeogenesis." [ISBN:0198506732]


id: GO:0030389
name: fructosamine metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving fructosamine, a fructose molecule containing an amino group in place of a hydroxyl group." [GOC:jl, ISBN:0192801023]


id: GO:0030391
name: fructosamine biosynthetic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of fructosamine, a fructose molecule containing an amino group in place of a hydroxyl group." [GOC:jl, ISBN:0192801023]


id: GO:0030392
name: fructosamine catabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the breakdown of fructosamine, a fructose molecule containing an amino group in place of a hydroxyl group." [GOC:jl, ISBN:0192801023]


id: GO:0030393
name: fructoselysine metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving fructoselysine, a fructose molecule containing a lysine group in place of a hydroxyl group." [GOC:ai]


id: GO:0030394
name: fructoseglycine metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving fructoseglycine, a fructose molecule containing a glycine group in place of a hydroxyl group." [GOC:ai]


id: GO:0030395
name: lactose binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with lactose, a disaccharide of glucose and galactose, the carbohydrate of milk." [GOC:jl, ISBN:01928006X]


id: GO:0030397
name: membrane disassembly
namespace: biological_process
def:
  "The controlled breakdown of any cell membrane in the context of a normal process such as autophagy." [GOC:mah]


id: GO:0030398
name: peroxisomal membrane disassembly
namespace: biological_process
def:
  "The controlled breakdown of the membranes of cargo-carrying vesicles formed during peroxisome degradation." [GOC:mah, PMID:11382760]


id: GO:0030400
name: obsolete protease substrate recruitment factor activity
namespace: molecular_function
def:
  "OBSOLETE. A recruiting factor or adaptor molecule associated with the proteasome that activates degradation of specific proteasomal substrates and links them to the degradation machinery; it is not involved in ubiquitination; does not possess proteolytic activity." [PMID:11500370]


id: GO:0030401
name: obsolete transcription antiterminator activity
namespace: molecular_function
def:
  "OBSOLETE. Functions to prevent the termination of RNA synthesis. Acts as a regulatory device, e.g. in phage lambda, enabling a terminator to be masked from RNA polymerase so that distal genes can be expressed." [ISBN:0198506732]


id: GO:0030407
name: formimidoyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the transfer of a formimino group from 5-formimidoyltetrahydrofolate to an acceptor molecule such as an amino acid." [EC:2.1.2.4, EC:2.1.2.5, GOC:mah]


id: GO:0030408
name: glycine formimidoyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 5-formimidoyltetrahydrofolate + glycine = (6S)-5,6,7,8-tetrahydrofolate + N-formimidoylglycine." [EC:2.1.2.4, RHEA:24291]


id: GO:0030409
name: glutamate formimidoyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 5-formimidoyltetrahydrofolate + L-glutamate = tetrahydrofolate + N-formimidoyl-L-glutamate." [EC:2.1.2.5]


id: GO:0030410
name: nicotianamine synthase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 3 S-adenosyl-L-methionine(1+) = 3 S-methyl-5'-thioadenosine + 3 H(+) + nicotianamine." [EC:2.5.1.43, RHEA:16484]


id: GO:0030411
name: scytalone dehydratase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: scytalone = 1,3,8-trihydroxynaphthalene + H(2)O." [EC:4.2.1.94, RHEA:24399]


id: GO:0030412
name: formimidoyltetrahydrofolate cyclodeaminase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 5-formimidoyltetrahydrofolate + 2 H(+) = 5,10-methenyltetrahydrofolate + NH(4)(+)." [EC:4.3.1.4, RHEA:22739]


id: GO:0030413
name: competence pheromone activity
namespace: molecular_function
def:
  "A small peptide excreted by a naturally transformable bacterium (e.g. Bacillus subtilis) that transmits a signal required for the establishment of competence." [GOC:mah, PMID:7698645]


id: GO:0030414
name: peptidase inhibitor activity
namespace: molecular_function
def:
  "Stops, prevents or reduces the activity of a peptidase, any enzyme that catalyzes the hydrolysis peptide bonds." [GOC:jl]


id: GO:0030417
name: nicotianamine metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving nicotianamine, 2(S),3'2(S),3''(S)-N-(N-(3-amino-3-carboxypropyl)-3-amino-3-carboxypropyl)-azetidine-2-carboxylic acid." [GOC:mah, PMID:10069850]


id: GO:0030418
name: nicotianamine biosynthetic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of nicotianamine, 2(S),3'2(S),3''(S)-N-(N-(3-amino-3-carboxypropyl)-3-amino-3-carboxypropyl)-azetidine-2-carboxylic acid." [GOC:mah, PMID:10069850]


id: GO:0030419
name: nicotianamine catabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the breakdown of nicotianamine, 2(S),3'2(S),3''(S)-N-(N-(3-amino-3-carboxypropyl)-3-amino-3-carboxypropyl)-azetidine-2-carboxylic acid." [GOC:mah, PMID:10069850]


id: GO:0030420
name: establishment of competence for transformation
namespace: biological_process
def:
  "The process in which a naturally transformable bacterium acquires the ability to take up exogenous DNA. This term should be applied only to naturally transformable bacteria, and should not be used in the context of artificially induced bacterial transformation." [GOC:mah, ISBN:1555811027]


id: GO:0030422
name: production of siRNA involved in RNA interference
namespace: biological_process
def:
  "Cleavage of double-stranded RNA to form small interfering RNA molecules (siRNAs) of 21-23 nucleotides, in the context of RNA interference." [GOC:mah, PMID:11524674]


id: GO:0030423
name: targeting of mRNA for destruction involved in RNA interference
namespace: biological_process
def:
  "The process in which small interfering RNAs target cognate mRNA molecules for degradation." [PMID:11524674]


id: GO:0030424
name: axon
namespace: cellular_component
def:
  "The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter." [GOC:nln, ISBN:0198506732]


id: GO:0030425
name: dendrite
namespace: cellular_component
def:
  "A neuron projection that has a short, tapering, often branched, morphology, receives and integrates signals from other neurons or from sensory stimuli, and conducts a nerve impulse towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body." [GOC:dos, GOC:mah, GOC:nln, ISBN:0198506732]


id: GO:0030428
name: cell septum
namespace: cellular_component
def:
  "A structure composed of peptidoglycan and often chitin in addition to other materials. It usually forms perpendicular to the long axis of a cell or hypha and grows centripetally from the cell wall to the center of the cell and often functions in the compartmentalization of a cell into two daughter cells." [GOC:clt, ISBN:0471940526]


id: GO:0030431
name: sleep
namespace: biological_process
def:
  "Any process in which an organism enters and maintains a periodic, readily reversible state of reduced awareness and metabolic activity. Usually accompanied by physical relaxation, the onset of sleep in humans and other mammals is marked by a change in the electrical activity of the brain." [ISBN:0192800981]


id: GO:0030432
name: peristalsis
namespace: biological_process
def:
  "A wavelike sequence of involuntary muscular contraction and relaxation that passes along a tubelike structure, such as the intestine, impelling the contents onwards." [ISBN:0198506732]


id: GO:0030433
name: ER-associated ubiquitin-dependent protein catabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the breakdown of proteins transported from the endoplasmic reticulum and targeted to cytoplasmic proteasomes for degradation. This process acts on misfolded proteins as well as in the regulated degradation of correctly folded proteins." [GOC:mah, GOC:rb, PMID:14607247, PMID:19520858]


id: GO:0030435
name: sporulation resulting in formation of a cellular spore
namespace: biological_process
def:
  "The process in which a relatively unspecialized cell acquires the specialized features of a cellular spore, a cell form that can be used for dissemination, for survival of adverse conditions because of its heat and dessication resistance, and/or for reproduction." [GOC:mah, GOC:pamgo_curators, ISBN:0072992913]


id: GO:0030436
name: asexual sporulation
namespace: biological_process
def:
  "The formation of spores derived from the products of mitosis. Examples of this process are found in Bacterial species." [GOC:mah, PMID:9529886]


id: GO:0030437
name: ascospore formation
namespace: biological_process
def:
  "The process in which cells that are products of meiosis acquire the specialized features of ascospores. Ascospores are generally found in clusters of four or eight spores within a single mother cell, the ascus, and are characteristic of the ascomycete fungi (phylum Ascomycota)." [GOC:di, GOC:mah, GOC:mcc, PMID:16339736]


id: GO:0030445
name: yeast-form cell wall
namespace: cellular_component
def:
  "The wall surrounding a cell of a dimorphic fungus growing in the single-cell budding yeast form, in contrast to the filamentous or hyphal form." [GOC:mah, GOC:mcc]


id: GO:0030447
name: filamentous growth
namespace: biological_process
def:
  "The process in which a multicellular organism, a unicellular organism or a group of unicellular organisms grow in a threadlike, filamentous shape." [GOC:mcc, PMID:11729141]


id: GO:0030448
name: hyphal growth
namespace: biological_process
def:
  "Growth of fungi as threadlike, tubular structures that may contain multiple nuclei and may or may not be divided internally by septa, or cross-walls." [GOC:mcc, ISBN:0471522295]


id: GO:0030449
name: regulation of complement activation
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of complement activation." [GOC:go_curators]


id: GO:0030450
name: regulation of complement activation, classical pathway
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of the classical pathway of complement activation." [GOC:go_curators]


id: GO:0030451
name: regulation of complement activation, alternative pathway
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of the alternative pathway of complement activation." [GOC:go_curators]


id: GO:0030466
name: chromatin silencing at silent mating-type cassette
namespace: biological_process
def:
  "Repression of transcription at silent mating-type loci by alteration of the structure of chromatin." [GOC:mcc]


id: GO:0030470
name: obsolete spore germination (sensu Fungi)
namespace: biological_process
def:
  "OBSOLETE. Process of breakdown or opening of the spore-containing structure, modification of the spore wall, and resumption of growth of the spore. As in, but not restricted to, the fungi (Fungi, ncbi_taxonomy_id:4751)." [GOC:mcc]


id: GO:0030471
name: obsolete spindle pole body and microtubule cycle (sensu Fungi)
namespace: biological_process
def:
  "OBSOLETE. The dynamics of the spindle pole body and microtubule cytoskeleton during the cell cycle. Includes spindle pole body duplication and separation and formation and elongation of the mitotic spindle. As in, but not restricted to, the fungi (Fungi, ncbi_taxonomy_id:4751)." [ISBN:0879693649]


id: GO:0030472
name: mitotic spindle organization in nucleus
namespace: biological_process
def:
  "A process resulting in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle in the nucleus. The process occurs during a mitotic cell cycle and takes place at the cellular level." [GOC:mah]


id: GO:0030473
name: nuclear migration along microtubule
namespace: biological_process
def:
  "The directed movement of the nucleus along microtubules within the cell, mediated by motor proteins." [GOC:mah, GOC:sgd_curators]


id: GO:0030476
name: ascospore wall assembly
namespace: biological_process
def:
  "The aggregation, arrangement and bonding together of a set of components to form an ascospore wall. During sporulation in Ascomycota, each ascospore nucleus becomes surrounded by a specialized spore wall, formed by deposition of spore wall components in the lumenal space between the outer and inner leaflets of the prospore membrane. An example of this process is found in Saccharomyces cerevisiae." [GOC:mcc, PMID:14702385]


id: GO:0030478
name: actin cap
namespace: cellular_component
def:
  "Polarized accumulation of cytoskeletal proteins (including F-actin) and regulatory proteins in a cell. An example of this is the actin cap found in Saccharomyces cerevisiae." [GOC:mah, ISBN:10652251]


id: GO:0030479
name: actin cortical patch
namespace: cellular_component
def:
  "An endocytic patch  that consists of an actin-containing structure found at the plasma membrane in cells; formed of networks of branched actin filaments that lie just beneath the plasma membrane and assemble, move, and disassemble rapidly. An example of this is the actin cortical patch found in Saccharomyces cerevisiae." [GOC:mah, GOC:vw, ISBN:0879693568, ISBN:0879693649, PMID:16959963]


id: GO:0030484
name: obsolete muscle fiber
namespace: cellular_component
def:
  "OBSOLETE. The contractile fibers, composed of actin, myosin, and associated proteins, found in cells of smooth or striated muscle." [GOC:mah, ISBN:0815316194]


id: GO:0030486
name: smooth muscle dense body
namespace: cellular_component
def:
  "Electron-dense region associated with a smooth muscle contractile fiber." [GOC:mah, ISBN:0815316194]


id: GO:0030487
name: inositol-4,5-bisphosphate 5-phosphatase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 1D-myo-inositol 4,5-bisphosphate + H2O = 1D-myo-inositol 4-phosphate + phosphate." [GOC:mah]


id: GO:0030488
name: tRNA methylation
namespace: biological_process
def:
  "The posttranscriptional addition of methyl groups to specific residues in a tRNA molecule." [GOC:mah]


id: GO:0030490
name: maturation of SSU-rRNA
namespace: biological_process
def:
  "Any process involved in the maturation of a precursor Small SubUnit (SSU) ribosomal RNA (rRNA) molecule into a mature SSU-rRNA molecule." [GOC:curators]


id: GO:0030491
name: heteroduplex formation
namespace: biological_process
def:
  "The formation of a stable duplex DNA that contains one strand from each of the two recombining DNA molecules." [GOC:elh, PMID:10357855]


id: GO:0030492
name: hemoglobin binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with hemoglobin, an oxygen carrying, conjugated protein containing four heme groups and globin." [CHEBI:35143, GOC:jl]


id: GO:0030493
name: bacteriochlorophyll metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving a bacteriochlorophyll, any of the chlorophylls of photosynthetic bacteria. They differ structurally from the chlorophylls of higher plants." [GOC:mah, ISBN:0198506732]


id: GO:0030494
name: bacteriochlorophyll biosynthetic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of a bacteriochlorophyll, any of the chlorophylls of photosynthetic bacteria. They differ structurally from the chlorophylls of higher plants." [GOC:mah, ISBN:0198506732]


id: GO:0030495
name: bacteriochlorophyll catabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the breakdown of bacteriochlorophyll, any of the chlorophylls of photosynthetic bacteria. They differ structurally from the chlorophylls of higher plants." [GOC:go_curators]


id: GO:0030496
name: midbody
namespace: cellular_component
def:
  "A thin cytoplasmic bridge formed between daughter cells at the end of cytokinesis. The midbody forms where the contractile ring constricts, and may persist for some time before finally breaking to complete cytokinesis." [ISBN:0815316194]


id: GO:0030497
name: fatty acid elongation
namespace: biological_process
def:
  "The elongation of a fatty acid chain by the sequential addition of two-carbon units." [ISBN:0716720094]


id: GO:0030500
name: regulation of bone mineralization
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of bone mineralization." [GOC:go_curators]


id: GO:0030501
name: positive regulation of bone mineralization
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of bone mineralization." [GOC:go_curators]


id: GO:0030502
name: negative regulation of bone mineralization
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of bone mineralization." [GOC:go_curators]


id: GO:0030505
name: inorganic diphosphate transport
namespace: biological_process
def:
  "The directed movement of inorganic diphosphate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah]


id: GO:0030506
name: ankyrin binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with ankyrin, a 200 kDa cytoskeletal protein that attaches other cytoskeletal proteins to integral membrane proteins." [GOC:mah, ISBN:0198506732]


id: GO:0030507
name: spectrin binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with spectrin, a protein that is the major constituent of the erythrocyte cytoskeletal network. It associates with band 4.1 (see band protein) and actin to form the cytoskeletal superstructure of the erythrocyte plasma membrane. It is composed of nonhomologous chains, alpha and beta, which aggregate side-to-side in an antiparallel fashion to form dimers, tetramers, and higher polymers." [GOC:mah, ISBN:0198506732]


id: GO:0030508
name: obsolete thiol-disulfide exchange intermediate activity
namespace: molecular_function
def:
  "OBSOLETE. Functions as an exchange intermediate in thiol-disulfide exchange reactions." [GOC:kd, GOC:mah]


id: GO:0030509
name: BMP signaling pathway
namespace: biological_process
def:
  "A series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:signaling, ISBN:0878932437, PR:000000034]


id: GO:0030510
name: regulation of BMP signaling pathway
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of the activity of any BMP receptor signaling pathway." [GOC:mah]


id: GO:0030511
name: positive regulation of transforming growth factor beta receptor signaling pathway
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of TGF-beta receptor signaling pathway activity." [GOC:go_curators]


id: GO:0030512
name: negative regulation of transforming growth factor beta receptor signaling pathway
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of any TGF-beta receptor signaling pathway." [GOC:mah]


id: GO:0030513
name: positive regulation of BMP signaling pathway
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of BMP signaling pathway activity." [GOC:go_curators]


id: GO:0030514
name: negative regulation of BMP signaling pathway
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of the BMP signaling pathway." [GOC:go_curators]


id: GO:0030517
name: negative regulation of axon extension
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of axon outgrowth." [GOC:mah]


id: GO:0030518
name: intracellular steroid hormone receptor signaling pathway
namespace: biological_process
def:
  "A series of molecular signals generated as a consequence of a intracellular steroid hormone receptor binding to one of its physiological ligands." [GOC:mah, GOC:signaling]


id: GO:0030519
name: snoRNP binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with any part of a small nucleolar ribonucleoprotein particle." [GOC:mah]


id: GO:0030520
name: intracellular estrogen receptor signaling pathway
namespace: biological_process
def:
  "Any series of molecular signals generated as a consequence of an intracellular estrogen receptor binding to one of its physiological ligands. The pathway begins with receptor-ligand binding, and ends with regulation of a downstream cellular process (e.g. transcription)." [GOC:mah, GOC:signaling]


id: GO:0030521
name: androgen receptor signaling pathway
namespace: biological_process
def:
  "Any series of molecular signals generated as a consequence of an androgen binding to its receptor." [GOC:mah]


id: GO:0030522
name: intracellular receptor signaling pathway
namespace: biological_process
def:
  "Any series of molecular signals initiated by a ligand binding to an receptor located within a cell." [GOC:bf, GOC:mah]


id: GO:0030523
name: dihydrolipoamide S-acyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: acyl-CoA + dihydrolipoamide = CoA + S-acyldihydrolipoamide." [EC:2.3.1.12, GOC:mah]


id: GO:0030528
name: obsolete transcription regulator activity
namespace: molecular_function
def:
  "OBSOLETE. Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor." [GOC:mah]


id: GO:0030529
name: intracellular ribonucleoprotein complex
namespace: cellular_component
def:
  "An intracellular macromolecular complex containing both protein and RNA molecules." [GOC:krc, GOC:vesicles]


id: GO:0030530
name: obsolete heterogeneous nuclear ribonucleoprotein complex
namespace: cellular_component
def:
  "OBSOLETE. Particulate complex of heterogeneous nuclear RNA (hnRNA; a heterogeneous mixture of RNA molecules of high Mr with a rapid turnover rate that occurs in cell nuclei during protein synthesis; it is the form of RNA synthesized in eukaryotes by RNA polymerase II, that which is translated into protein) with protein, which is cell-specific and heterogeneous. The protein component may play a role in the processing of the hnRNA to mRNA." [ISBN:0198506732]


id: GO:0030531
name: obsolete small cytoplasmic ribonucleoprotein complex
namespace: cellular_component
def:
  "OBSOLETE. A complex composed of RNA of the small cytoplasmic RNA (scRNA) class and protein, found in the cytoplasm." [GOC:krc, GOC:mah]


id: GO:0030532
name: small nuclear ribonucleoprotein complex
namespace: cellular_component
def:
  "A complex composed of RNA of the small nuclear RNA (snRNA) class and protein, found in the nucleus of a eukaryotic cell. These are typically named after the snRNA(s) they contain, e.g. U1 snRNP or U4/U6 snRNP. Many, but not all, of these complexes are involved in splicing of nuclear mRNAs." [GOC:krc, GOC:mah, ISBN:0879695897]


id: GO:0030533
name: triplet codon-amino acid adaptor activity
namespace: molecular_function
def:
  "The codon binding activity of a tRNA that positions an activated amino acid, mediating its insertion at the correct point in the sequence of a nascent polypeptide chain during protein synthesis." [GOC:hjd, GOC:mtg_MIT_16mar07, ISBN:0198506732]


id: GO:0030535
name: obsolete adult feeding behavior (sensu Insecta)
namespace: biological_process
def:
  "OBSOLETE. Feeding behavior in a fully developed and mature organism, as described in insects." [GOC:go_curators, GOC:jid]


id: GO:0030537
name: larval behavior
namespace: biological_process
def:
  "Behavior in a larval form of an organism, an immature organism that must undergo metamorphosis to assume adult characteristics." [GOC:mah, ISBN:0877797099]


id: GO:0030538
name: embryonic genitalia morphogenesis
namespace: biological_process
def:
  "The process, occurring in the embryo, by which the anatomical structures of the genitalia are generated and organized." [GOC:bf]


id: GO:0030539
name: male genitalia development
namespace: biological_process
def:
  "The process whose specific outcome is the progression of the male genitalia over time, from its formation to the mature structure." [GOC:ems, ISBN:0140512888]


id: GO:0030540
name: female genitalia development
namespace: biological_process
def:
  "The process whose specific outcome is the progression of the female genitalia over time, from formation to the mature structure." [GOC:mah]


id: GO:0030541
name: plasmid partitioning
namespace: biological_process
def:
  "Any process in which plasmids are segregated or distributed into daughter cells upon cell division." [GOC:mah]


id: GO:0030543
name: 2-micrometer plasmid partitioning
namespace: biological_process
def:
  "The process in which copies of the 2-micrometer plasmid, found in fungi such as Saccharomyces, are distributed to daughter cells upon cell division." [GOC:mah]


id: GO:0030544
name: Hsp70 protein binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with Hsp70 proteins, any of a group of heat shock proteins around 70kDa in size." [ISBN:0198506732]


id: GO:0030545
name: receptor regulator activity
namespace: molecular_function
def:
  "The function of interacting (directly or indirectly) with receptors such that the proportion of receptors in the active form is changed." [GOC:ceb]


id: GO:0030546
name: receptor activator activity
namespace: molecular_function
def:
  "The function of interacting (directly or indirectly) with receptors such that the proportion of receptors in the active form is increased." [GOC:ceb]


id: GO:0030547
name: receptor inhibitor activity
namespace: molecular_function
def:
  "The function of interacting (directly or indirectly) with receptors such that the proportion of receptors in the active form is decreased." [GOC:ceb]


id: GO:0030548
name: acetylcholine receptor regulator activity
namespace: molecular_function
def:
  "Interacting (directly or indirectly) with acetylcholine receptors such that the proportion of receptors in the active form is changed." [GOC:mah]


id: GO:0030549
name: acetylcholine receptor activator activity
namespace: molecular_function
def:
  "Interacting (directly or indirectly) with acetylcholine receptors such that the proportion of receptors in the active form is increased." [GOC:mah]


id: GO:0030550
name: acetylcholine receptor inhibitor activity
namespace: molecular_function
def:
  "Interacting (directly or indirectly) with acetylcholine receptors such that the proportion of receptors in the active form is decreased." [GOC:mah]


id: GO:0030551
name: cyclic nucleotide binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with a cyclic nucleotide, a nucleotide in which the phosphate group is in diester linkage to two positions on the sugar residue." [GOC:ai]


id: GO:0030552
name: cAMP binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with cAMP, the nucleotide cyclic AMP (adenosine 3',5'-cyclophosphate)." [GOC:ai]


id: GO:0030553
name: cGMP binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with cGMP, the nucleotide cyclic GMP (guanosine 3',5'-cyclophosphate)." [GOC:ai]


id: GO:0030554
name: adenyl nucleotide binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with adenyl nucleotides, any compound consisting of adenosine esterified with (ortho)phosphate." [ISBN:0198506732]


id: GO:0030555
name: RNA modification guide activity
namespace: molecular_function
def:
  "Specifies the site of a posttranscriptional modification in an RNA molecule by base pairing with a short sequence around the target residue." [GOC:mah, PMID:12457565]


id: GO:0030556
name: rRNA modification guide activity
namespace: molecular_function
def:
  "Specifies the site of a posttranscriptional modification in an rRNA molecule by base pairing with a short sequence around the target residue." [GOC:mah, PMID:12457565]


id: GO:0030557
name: tRNA modification guide activity
namespace: molecular_function
def:
  "Specifies the site of a posttranscriptional modification in a tRNA molecule by base pairing with a short sequence around the target residue." [GOC:mah, PMID:12457565]


id: GO:0030558
name: RNA pseudouridylation guide activity
namespace: molecular_function
def:
  "Specifies the site of pseudouridylation in an RNA molecule by base pairing with a short sequence around the target residue." [GOC:mah, PMID:12457565]


id: GO:0030559
name: rRNA pseudouridylation guide activity
namespace: molecular_function
def:
  "Specifies the site of pseudouridylation in an rRNA molecule by base pairing with a short sequence around the target residue." [GOC:mah, PMID:12457565]


id: GO:0030560
name: tRNA pseudouridylation guide activity
namespace: molecular_function
def:
  "Specifies the site of pseudouridylation in a tRNA molecule by base pairing with a short sequence around the target residue." [GOC:mah, PMID:12457565]


id: GO:0030561
name: RNA 2'-O-ribose methylation guide activity
namespace: molecular_function
def:
  "Specifies the site of 2'-O-ribose methylation in an RNA molecule by base pairing with a short sequence around the target residue." [GOC:mah, PMID:12457565]


id: GO:0030562
name: rRNA 2'-O-ribose methylation guide activity
namespace: molecular_function
def:
  "Specifies the site of 2'-O-ribose methylation in an rRNA molecule by base pairing with a short sequence around the target residue." [GOC:mah, PMID:12457565]


id: GO:0030563
name: snRNA 2'-O-ribose methylation guide activity
namespace: molecular_function
def:
  "Activity that provides specificity to a methylase by using base complementarity to guide site-specific 2'-O-ribose methylations to a small nuclear RNA molecule." [PMID:11733745]


id: GO:0030564
name: tRNA 2'-O-ribose methylation guide activity
namespace: molecular_function
def:
  "Specifies the site of 2'-O-ribose methylation in a tRNA molecule by base pairing with a short sequence around the target residue." [GOC:mah, PMID:12457565]


id: GO:0030565
name: snRNA pseudouridylation guide activity
namespace: molecular_function
def:
  "Activity that provides specificity to a pseudouridine synthetase by using base complementarity to guide site-specific pseudouridylations to a small nuclear RNA molecule." [PMID:11733745]


id: GO:0030566
name: snRNA modification guide activity
namespace: molecular_function
def:
  "Specifies the site of a posttranscriptional modification in an snRNA molecule by base pairing with a short sequence around the target residue." [GOC:mah, PMID:12457565]


id: GO:0030569
name: obsolete chymotrypsin inhibitor activity
namespace: molecular_function
def:
  "OBSOLETE. Stops, prevents or reduces the activity of the serine endopeptidase chymotrypsin." [GOC:mah]


id: GO:0030570
name: pectate lyase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: a pectate = a pectate + a pectate oligosaccharide with 4-(4-deoxy-alpha-D-galact-4-enuronosyl)-D-galacturonate end. This reaction is the eliminative cleavage of pectate to give oligosaccharides with 4-deoxy-alpha-D-gluc-4-enuronosyl groups at their non-reducing ends." [EC:4.2.2.2]


id: GO:0030572
name: phosphatidyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction involving the transfer of a phosphatidate (otherwise known as diacylglycerol 3-phosphosphate) group." [GOC:mb]


id: GO:0030573
name: bile acid catabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the breakdown of bile acids, any of a group of steroid carboxylic acids occurring in bile." [GOC:go_curators]


id: GO:0030574
name: collagen catabolic process
namespace: biological_process
def:
  "The proteolytic chemical reactions and pathways resulting in the breakdown of collagen in the extracellular matrix, usually carried out by proteases secreted by nearby cells." [GOC:mah, ISBN:0815316194]


id: GO:0030575
name: nuclear body organization
namespace: biological_process
def:
  "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of any of the extra-nucleolar nuclear domains usually visualized by confocal microscopy and fluorescent antibodies to specific proteins." [GOC:dph, GOC:jl, GOC:mah]


id: GO:0030576
name: Cajal body organization
namespace: biological_process
def:
  "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of Cajal bodies, nuclear bodies that appear ultrastructurally as a tangle of coiled, electron-dense threads roughly 0.5 micrometers in diameter and are enriched in ribonucleoproteins, and certain general RNA polymerase II transcription factors." [GOC:mah, PMID:11031238]


id: GO:0030577
name: Lands organization
namespace: biological_process
def:
  "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of Lands, a class of nuclear body that react against SP140 auto-antibodies." [GOC:mah, PMID:10921892, PMID:8695863]


id: GO:0030578
name: PML body organization
namespace: biological_process
def:
  "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of PML bodies, a class of nuclear body; they react against SP100 auto-antibodies (PML = promyelocytic leukemia)." [GOC:mah, PMID:10806078]


id: GO:0030579
name: ubiquitin-dependent SMAD protein catabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the breakdown of SMAD signaling proteins by ubiquitination and targeting to the proteasome." [GOC:go_curators]


id: GO:0030580
name: quinone cofactor methyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the transfer of a methyl group from S-adenosylmethionine during the synthesis of quinone cofactors such as ubiquinone (coenzyme Q), menaquinone (vitamin K2), plastoquinone and phylloquinone (vitamin K1)." [GOC:mb]


id: GO:0030581
name: symbiont intracellular protein transport in host
namespace: biological_process
def:
  "The directed movement of a symbiont's proteins within a cell of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mb]


id: GO:0030582
name: fruiting body development
namespace: biological_process
def:
  "The process whose specific outcome is the progression of the fruiting body over time, from its formation to the mature structure. A fruiting body is a multicellular structure that contains spores." [GOC:mah, GOC:mtg_sensu]


id: GO:0030583
name: myxococcal fruiting body development
namespace: biological_process
def:
  "The process whose specific outcome is the progression of the myxococcal fruiting body over time, from its formation to the mature structure. The process begins when myxococci respond to a lack of nutrients in the environment and ends when the myxococcal fruiting body is a mature structure." [GOC:mtg_sensu, ISBN:0815316194, PMID:11121786]


id: GO:0030584
name: sporocarp development
namespace: biological_process
def:
  "The process whose specific outcome is the progression of a sporocarp over time, from its formation to the mature structure. The sporocarp is a spore bearing fruiting body organ. An example of this process is found in the Fungal species Coprinopsis cinerea." [GOC:mah, GOC:mtg_sensu]


id: GO:0030585
name: phosphoenolpyruvate carboxykinase (diphosphate) activity
namespace: molecular_function
def:
  "Catalysis of the reaction: diphosphate + oxaloacetate = CO(2) + phosphate + phosphoenolpyruvate." [EC:4.1.1.38, RHEA:22359]


id: GO:0030586
name: [methionine synthase] reductase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: [methionine synthase]-cob(II)alamin + NADPH + H+ + S-adenosyl methionine = [methionine synthase]-methylcob(I)alamin + S-adenosylhomocysteine + NADP+." [EC:1.16.1.8]


id: GO:0030587
name: sorocarp development
namespace: biological_process
def:
  "The process whose specific outcome is the progression of the sorocarp over time, from its formation to the mature structure. The process begins with the aggregation of individual cells and ends with the mature sorocarp. The sorocarp is a structure containing a spore-bearing sorus that sits on top of a stalk. An example of this process is found in Dictyostelium discoideum." [dictyBase_REF:2530, GOC:mah, GOC:mtg_sensu, ISBN:0521583640]


id: GO:0030588
name: pseudocleavage
namespace: biological_process
def:
  "Partial constriction of the cytoplasm of an embryo to form a furrow that resembles a cleavage furrow but does not complete cytokinesis." [GOC:mah, PMID:10751167, PMID:7729583]


id: GO:0030589
name: pseudocleavage involved in syncytial blastoderm formation
namespace: biological_process
def:
  "Formation of furrows in the cytoplasm between nuclei during cell cycles in embryos that contribute to the formation of the syncytial blastoderm. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu]


id: GO:0030590
name: first cell cycle pseudocleavage
namespace: biological_process
def:
  "A process that occurs during the first cell cycle in an embryo, in which anterior cortical contractions culminate in a single partial constriction of the embryo called the pseudocleavage furrow. An example of this process is found in nematode worms." [GOC:mtg_sensu, PMID:7729583]


id: GO:0030591
name: NAD DNA ADP-ribosyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the transfer of the ADP-ribose group of NAD+ to the amino group at N2 of 2'-deoxyguanosine to yield N2-(alpha-ADP-ribos-1-yl)-2'-deoxyguanosine and its beta form." [PMID:11592983]


id: GO:0030592
name: DNA ADP-ribosylation
namespace: biological_process
def:
  "The covalent attachment of an ADP-ribosyl group to the amino group at N2 of a 2'-deoxyguanosine residue in double-stranded DNA." [PMID:11592983]


id: GO:0030593
name: neutrophil chemotaxis
namespace: biological_process
def:
  "The directed movement of a neutrophil cell, the most numerous polymorphonuclear leukocyte found in the blood, in response to an external stimulus, usually an infection or wounding." [GOC:jl, ISBN:0198506732]


id: GO:0030594
name: neurotransmitter receptor activity
namespace: molecular_function
def:
  "Combining with a neurotransmitter and transmitting the signal to initiate a change in cell activity." [GOC:jl, GOC:signaling]


id: GO:0030596
name: alpha-L-rhamnosidase activity
namespace: molecular_function
def:
  "Catalysis of the hydrolysis of terminal non-reducing alpha-L-rhamnose residues in alpha-L-rhamnosides." [EC:3.2.1.40]


id: GO:0030598
name: rRNA N-glycosylase activity
namespace: molecular_function
def:
  "Catalysis of the hydrolysis of the N-glycosylic bond at A-4324 in 28S rRNA from rat ribosomes or corresponding sites in 28S RNA from other species." [EC:3.2.2.22, GOC:mah]


id: GO:0030600
name: feruloyl esterase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: feruloyl-polysaccharide + H2O = ferulate + polysaccharide." [EC:3.1.1.73]


id: GO:0030601
name: obsolete aminopeptidase B activity
namespace: molecular_function
def:
  "OBSOLETE. Catalysis of the release of N-terminal Arg and Lys from oligopeptides when P1' is not Pro. Also acts on arylamides of Arg and Lys." [EC:3.4.11.6]


id: GO:0030602
name: obsolete chymosin activity
namespace: molecular_function
def:
  "OBSOLETE. Catalysis of the lysis of peptide bonds with broad specificity similar to that of pepsin A. Clots milk by cleavage of a single Ser-Phe-l-Met-Ala bond in kappa-casein." [EC:3.4.23.4]


id: GO:0030603
name: oxaloacetase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: H(2)O + oxaloacetate = acetate + H(+) + oxalate." [EC:3.7.1.1, RHEA:24435]


id: GO:0030604
name: 1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 2-C-methyl-D-erythritol 4-phosphate + NADP(+) = 1-deoxy-D-xylulose 5-phosphate + H(+) + NADPH." [EC:1.1.1.267, RHEA:13720]


id: GO:0030612
name: arsenate reductase (thioredoxin) activity
namespace: molecular_function
def:
  "Catalysis of the reaction: arsenate + thioredoxin = arsenite + thioredoxin disulfide. Thioredoxin disulfide is also known as oxidized thioredoxin." [MetaCyc:RXN-10737]


id: GO:0030613
name: oxidoreductase activity, acting on phosphorus or arsenic in donors
namespace: molecular_function
def:
  "Catalysis of an oxidation-reduction (redox) reaction in which a phosphorus- or arsenic-containing group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:mah]


id: GO:0030614
name: oxidoreductase activity, acting on phosphorus or arsenic in donors, disulfide as acceptor
namespace: molecular_function
def:
  "Catalysis of an oxidation-reduction (redox) reaction in which a phosphorus- or arsenic-containing group acts as a hydrogen or electron donor and reduces a disulfide." [GOC:mah]


id: GO:0030616
name: transforming growth factor beta receptor, common-partner cytoplasmic mediator activity
namespace: molecular_function
def:
  "A TGF-beta cytoplasmic mediator that forms a complex with a phosphorylated pathway-specific mediator. The heterocomplex translocates to the nucleus to regulate transcription." [GOC:hjd]


id: GO:0030617
name: transforming growth factor beta receptor, inhibitory cytoplasmic mediator activity
namespace: molecular_function
def:
  "A TGF-beta cytoplasmic mediator that inhibits the signaling function of common-partner and pathway-specific mediators." [PMID:9759503]


id: GO:0030618
name: transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity
namespace: molecular_function
def:
  "A TGF-beta cytoplasmic mediator that is phosphorylated by a TGFbeta receptor and complexes with a common-partner mediator. The- heterocomplex translocates to the nucleus to regulate transcription." [GOC:hjd]


id: GO:0030622
name: U4atac snRNA binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with the U4atac small nuclear RNA (U4atac snRNA)." [GOC:jl]


id: GO:0030624
name: U6atac snRNA binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with the U6atac small nuclear RNA (U6atac snRNA)." [GOC:jl]


id: GO:0030629
name: U6 snRNA 3'-end binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with the 3' end of the U6 small nuclear RNA (U6 snRNA)." [GOC:mah]


id: GO:0030631
name: pyrrolysine incorporation
namespace: biological_process
def:
  "The incorporation of pyrrolysine, also known as lysine methylamine methyltransferase cofactor adduct, into a peptide; uses a special tRNA that recognizes the UAG codon as a modified lysine, rather than as a termination codon. Pyrrolysine may be synthesized as a free amino acid or synthesized from a lysine charged tRNA before its incorporation; it is not a posttranslational modification of peptidyl-lysine; this modification is found in several Methanosarcina methylamine methyltransferases." [PMID:11435424, PMID:17204561, RESID:AA0321]


id: GO:0030632
name: D-alanine biosynthetic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of D-alanine, the D-enantiomer of the amino acid alanine, i.e (2R)-2-aminopropanoic acid." [CHEBI:15570, GOC:jsg, GOC:mah]


id: GO:0030633
name: D-alanine family amino acid catabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the breakdown of D-alanine and related amino acids." [GOC:mah]


id: GO:0030634
name: carbon fixation by acetyl-CoA pathway
namespace: biological_process
def:
  "A pathway of carbon dioxide fixation in which one molecule of acetyl-CoA is completely synthesized from two molecules of carbon dioxide (CO2)." [PMID:11607093]


id: GO:0030636
name: obsolete acetate derivative biosynthetic process
namespace: biological_process
def:
  "OBSOLETE. The chemical reactions and pathways resulting in the formation of derivatives of acetic acid." [GOC:mah]


id: GO:0030637
name: obsolete acetate derivative catabolic process
namespace: biological_process
def:
  "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of derivatives of acetic acid." [GOC:ai]


id: GO:0030638
name: polyketide metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving polyketides, any of a diverse group of natural products synthesized via linear poly-beta-ketones, which are themselves formed by repetitive head-to-tail addition of acetyl (or substituted acetyl) units indirectly derived from acetate (or a substituted acetate) by a mechanism similar to that for fatty acid biosynthesis but without the intermediate reductive steps." [GOC:mah, ISBN:0198506732]


id: GO:0030639
name: polyketide biosynthetic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of polyketides, any of a diverse group of natural products synthesized via linear poly-beta-ketones, which are themselves formed by repetitive head-to-tail addition of acetyl (or substituted acetyl) units indirectly derived from acetate (or a substituted acetate) by a mechanism similar to that for fatty acid biosynthesis but without the intermediate reductive steps." [GOC:mah, ISBN:0198506732]


id: GO:0030640
name: polyketide catabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the breakdown of polyketides, any of a diverse group of natural products synthesized via linear poly-beta-ketones, which are themselves formed by repetitive head-to-tail addition of acetyl (or substituted acetyl) units indirectly derived from acetate (or a substituted acetate) by a mechanism similar to that for fatty acid biosynthesis but without the intermediate reductive steps." [GOC:mah, ISBN:0198506732]


id: GO:0030641
name: regulation of cellular pH
namespace: biological_process
def:
  "Any process involved in the maintenance of an internal equilibrium of hydrogen ions (protons) within a cell or between a cell and its external environment." [GOC:dph, GOC:mah, GOC:tb]


id: GO:0030642
name: cellular sulfate ion homeostasis
namespace: biological_process
def:
  "Any process involved in the maintenance of an internal steady state of sulfate ions at the level of a cell." [GOC:mah]


id: GO:0030643
name: cellular phosphate ion homeostasis
namespace: biological_process
def:
  "Any process involved in the maintenance of an internal steady state of phosphate ions at the level of a cell." [GOC:mah]


id: GO:0030644
name: cellular chloride ion homeostasis
namespace: biological_process
def:
  "Any process involved in the maintenance of an internal steady state of chloride ions at the level of a cell." [GOC:mah]


id: GO:0030645
name: glucose catabolic process to butyrate
namespace: biological_process
def:
  "The anaerobic chemical reactions and pathways resulting in the breakdown of glucose, with the production of acetic acid, butyric acid, carbon dioxide (CO2), and dihydrogen; effected by some saccharolytic species of Clostridium, e.g. C. butyricum." [ISBN:0198506732]


id: GO:0030647
name: aminoglycoside antibiotic metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving an aminoglycoside antibiotic, any member of a group of broad spectrum antibiotics, of similar toxicity and pharmacology, that contain an aminodeoxysugar, an amino- or guanidino-substituted inositol ring, and one or more residues of other sugars. The group includes streptomycin, neomycin, framycetin, kanamycin, paromomycin, and gentamicin." [GOC:mah, ISBN:0198506732]


id: GO:0030648
name: aminoglycoside antibiotic biosynthetic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of an aminoglycoside antibiotic, any member of a group of broad spectrum antibiotics, of similar toxicity and pharmacology, that contain an aminodeoxysugar, an amino- or guanidino-substituted inositol ring, and one or more residues of other sugars. The group includes streptomycin, neomycin, framycetin, kanamycin, paromomycin, and gentamicin." [GOC:mah, ISBN:0198506732]


id: GO:0030649
name: aminoglycoside antibiotic catabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the breakdown of an aminoglycoside antibiotic, any member of a group of broad spectrum antibiotics, of similar toxicity and pharmacology, that contain an aminodeoxysugar, an amino- or guanidino-substituted inositol ring, and one or more residues of other sugars. The group includes streptomycin, neomycin, framycetin, kanamycin, paromomycin, and gentamicin." [GOC:mah, ISBN:0198506732]


id: GO:0030651
name: peptide antibiotic biosynthetic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of peptides with antibiotic activity." [GOC:mah]


id: GO:0030652
name: peptide antibiotic catabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the breakdown of peptides with antibiotic activity." [GOC:mah]


id: GO:0030653
name: beta-lactam antibiotic metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving a beta-lactam antibiotic, any member of a class of natural or semisynthetic antibiotics whose characteristic feature is a strained, four-membered beta-lactam ring. They include the penicillins and many of the cephalosporins." [GOC:mah, ISBN:0198506732]


id: GO:0030654
name: beta-lactam antibiotic biosynthetic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of a beta-lactam antibiotic, any member of a class of natural or semisynthetic antibiotics whose characteristic feature is a strained, four-membered beta-lactam ring. They include the penicillins and many of the cephalosporins." [GOC:mah, ISBN:0198506732]


id: GO:0030655
name: beta-lactam antibiotic catabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the breakdown of a beta-lactam antibiotic, any member of a class of natural or semisynthetic antibiotics whose characteristic feature is a strained, four-membered beta-lactam ring. They include the penicillins and many of the cephalosporins." [GOC:mah, ISBN:0198506732]


id: GO:0030656
name: regulation of vitamin metabolic process
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a vitamin, one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body." [GOC:mah]


id: GO:0030657
name: obsolete regulation of coenzyme and prosthetic group metabolic process
namespace: biological_process
def:
  "OBSOLETE. Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving coenzymes and prosthetic groups." [GOC:ai]


id: GO:0030668
name: merozoite dense granule membrane
namespace: cellular_component
def:
  "The lipid bilayer surrounding a dense granule of the type found in apicomplexan parasites." [GOC:mah, GOC:mtg_sensu]


id: GO:0030673
name: axolemma
namespace: cellular_component
def:
  "The portion of the plasma membrane surrounding an axon; it is a specialized trilaminar random mosaic of protein molecules floating within a fluid matrix of highly mobile phospholipid molecules, 7-8 nm in thickness." [http://www.medik.sk/clanky/bio_jun.htm, ISBN:0124325653]


id: GO:0030674
name: protein binding, bridging
namespace: molecular_function
def:
  "The binding activity of a molecule that brings together two or more protein molecules, or a protein and another macromolecule or complex, through a selective, non-covalent, often stoichiometric interaction, permitting those molecules to function in a coordinated way." [GOC:bf, GOC:mah, GOC:vw]


id: GO:0030676
name: Rac guanyl-nucleotide exchange factor activity
namespace: molecular_function
def:
  "Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rac family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:mah]


id: GO:0030677
name: ribonuclease P complex
namespace: cellular_component
def:
  "A ribonucleoprotein complex that catalyzes cleavage of the leader sequence of precursor tRNAs (pre-tRNAs), generating the mature 5' end of tRNAs." [GOC:mah, PMID:12045094]


id: GO:0030678
name: mitochondrial ribonuclease P complex
namespace: cellular_component
def:
  "A ribonuclease P complex located in the mitochondrion of a eukaryotic cell, where it catalyzes the 5' endonucleolytic cleavage of precursor tRNAs to yield mature tRNAs. The subunit composition of mitochondrial ribonuclease P complexes varies between species, but the complex often contains a single RNA molecule and a single protein molecule." [GOC:mah, PMID:12045094]


id: GO:0030679
name: cyanelle ribonuclease P complex
namespace: cellular_component
def:
  "A ribonuclease P complex located in the cyanelle, where it catalyzes the 5' endonucleolytic cleavage of precursor tRNAs to yield mature tRNAs. The best characterized cyanelle ribonuclease P complex, from the alga Cyanophora paradoxa, contains a single RNA molecule that is necessary but not sufficient for catalysis, and several protein molecules." [GOC:mah, PMID:12045094]


id: GO:0030680
name: dimeric ribonuclease P complex
namespace: cellular_component
def:
  "A ribonuclease P complex that contains a single RNA molecule that is necessary and usually sufficient for catalysis, and a single protein molecule. Examples of this complex are found in Bacterial species." [GOC:mah, PMID:12045094]


id: GO:0030681
name: multimeric ribonuclease P complex
namespace: cellular_component
def:
  "A ribonuclease P complex that generally contains a single RNA molecule and several protein molecules. Examples of this complex are found in Archaeal species." [GOC:mah, PMID:11142368, PMID:12045094]


id: GO:0030682
name: evasion or tolerance of host defense response
namespace: biological_process
def:
  "Any process, either active or passive, by which an organism avoids or tolerates the effects of its host organism's defense response. The host defense response is mounted by the host in response to the presence of the organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06]


id: GO:0030683
name: evasion or tolerance by virus of host immune response
namespace: biological_process
def:
  "Any process, either active or passive, by which a virus avoids the effects of the host organism's immune response. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mah, GOC:pk]


id: GO:0030684
name: preribosome
namespace: cellular_component
def:
  "Any complex of pre-rRNAs, ribosomal proteins, and associated proteins formed during ribosome biogenesis." [PMID:10567516]


id: GO:0030685
name: nucleolar preribosome
namespace: cellular_component
def:
  "Any complex of pre-rRNAs, ribosomal proteins, and associated proteins formed in the nucleolus during ribosome biogenesis." [PMID:10567516]


id: GO:0030686
name: 90S preribosome
namespace: cellular_component
def:
  "A large ribonucleoprotein complex considered to be the earliest preribosomal complex. In S. cerevisiae, it has a size of 90S and consists of the 35S pre-rRNA, early-associating ribosomal proteins most of which are part of the small ribosomal subunit, the U3 snoRNA and associated proteins." [GOC:krc, GOC:vw, PMID:12150911, PMID:12957375, PMID:15120992]


id: GO:0030687
name: preribosome, large subunit precursor
namespace: cellular_component
def:
  "A preribosomal complex consisting of 27SA, 27SB, and/or 7S pre-rRNA, 5S rRNA, ribosomal proteins including late-associating large subunit proteins, and associated proteins; a precursor of the eukaryotic cytoplasmic large ribosomal subunit." [PMID:10567516]


id: GO:0030688
name: preribosome, small subunit precursor
namespace: cellular_component
def:
  "A preribosomal complex consisting of 20S pre-rRNA, ribosomal proteins including late-associating small subunit proteins, and associated proteins; a precursor of the eukaryotic cytoplasmic small ribosomal subunit." [PMID:10567516]


id: GO:0030689
name: Noc complex
namespace: cellular_component
def:
  "Any of several heterodimers containing one or two Noc proteins, associated with preribosomal complexes; involved in ribosome biogenesis." [PMID:12446671]


id: GO:0030690
name: Noc1p-Noc2p complex
namespace: cellular_component
def:
  "A heterodimer associated with 90S and 66S preribosomes. Predominantly, but not exclusively, nucleolar; involved in ribosomal large subunit biogenesis." [PMID:12446671]


id: GO:0030691
name: Noc2p-Noc3p complex
namespace: cellular_component
def:
  "A heterodimer associated with 66S preribosomes; predominantly nucleoplasmic, but also locates to the nucleolus; involved in ribosomal large subunit biogenesis." [PMID:12446671]


id: GO:0030692
name: Noc4p-Nop14p complex
namespace: cellular_component
def:
  "A heterodimer associated with precursors of the eukaryotic small ribosomal subunit, including the 90S preribosome; involved in small subunit biogenesis." [PMID:12446671]


id: GO:0030693
name: obsolete caspase activity
namespace: molecular_function
def:
  "OBSOLETE. Catalysis of the hydrolysis of a peptide bond on the carboxyl side of an aspartate residue." [PMID:10872455]


id: GO:0030694
name: bacterial-type flagellum basal body, rod
namespace: cellular_component
def:
  "The central portion of the flagellar basal body, which spans the periplasm and threads through the rings. Examples of this component are found in Bacterial species." [GOC:mtg_sensu, PMID:10572114, PMID:11133968, PMID:12624192]


id: GO:0030696
name: tRNA (m5U54) methyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the transfer of a methyl group from a donor to the C5 atom of the uridine residue at position 54 in a tRNA molecule." [ISBN:1555811337]


id: GO:0030697
name: S-adenosylmethionine-dependent tRNA (m5U54) methyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing thymine at position U54 of a transfer RNA. This occurs in most Gram-negative bacteria, some archae, and eukaryotes." [GOC:hjd, ISBN:1555811337]


id: GO:0030698
name: 5,10-methylenetetrahydrofolate-dependent tRNA (m5U54) methyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the transfer of a methyl group from 5,10-methylenetetrahydrofolate to the C5 atom of the uridine residue at position 54 in a tRNA molecule. This occurs in most Gram-positive bacteria and some Gram-negative bacteria." [GOC:hjd, ISBN:1555811337]


id: GO:0030699
name: glycine reductase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: acetyl phosphate + H(2)O + NH(4)(+) + thioredoxin disulfide = glycine + H(+) + phosphate + thioredoxin." [EC:1.21.4.2, RHEA:12235]


id: GO:0030700
name: glycine reductase complex
namespace: cellular_component
def:
  "Complex that possesses glycine reductase activity; usually comprises three subunits, of which two are selenoproteins; the subunits are typically designated selenoprotein A, selenoprotein B and protein C." [GOC:mah, PMID:2018775]


id: GO:0030701
name: NAD+-dinitrogen-reductase ADP-D-ribosyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: NAD+ + [dinitrogen reductase] = nicotinamide + ADP-D-ribosyl-[dinitrogen reductase]." [EC:2.4.2.37]


id: GO:0030703
name: eggshell formation
namespace: biological_process
def:
  "Construction of the eggshell, a product of the somatic follicle cell epithelium and a structure that supports the egg in a hostile environment, minimizing water loss whilst allowing gas exchanges essential for embryonic respiration." [GOC:mtg_sensu, ISBN:0879694238, PMID:10822261]


id: GO:0030704
name: vitelline membrane formation
namespace: biological_process
def:
  "Construction of the vitelline membrane portion of the egg shell, a rigid structure required to maintain the shape of the egg." [ISBN:0879694238]


id: GO:0030705
name: cytoskeleton-dependent intracellular transport
namespace: biological_process
def:
  "The directed movement of substances along cytoskeletal fibers such as microfilaments or microtubules within a cell." [GOC:mah]


id: GO:0030706
name: germarium-derived oocyte differentiation
namespace: biological_process
def:
  "The process in which one relatively unspecialized immature cystocyte of the germ-line cyst in the germarium acquires the specialized features of an oocyte. An example of this process can be found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238]


id: GO:0030707
name: ovarian follicle cell development
namespace: biological_process
def:
  "The process that occurs during oogenesis involving the ovarian follicle cells, somatic cells which surround the germ cells of an ovary. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:10822261]


id: GO:0030708
name: germarium-derived female germ-line cyst encapsulation
namespace: biological_process
def:
  "Formation of a single follicular epithelium around the germ-line derived cells of a cyst formed in the germarium. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:11591336]


id: GO:0030709
name: border follicle cell delamination
namespace: biological_process
def:
  "The delamination process that results in the splitting off of border cells from the anterior epithelium, prior to border cell migration." [PMID:10822261]


id: GO:0030710
name: regulation of border follicle cell delamination
namespace: biological_process
def:
  "Any process that regulates the frequency, rate or extent of border cell delamination." [PMID:10822261]


id: GO:0030711
name: positive regulation of border follicle cell delamination
namespace: biological_process
def:
  "Any process that increases the frequency, rate or extent of border cell delamination." [PMID:10822261]


id: GO:0030712
name: negative regulation of border follicle cell delamination
namespace: biological_process
def:
  "Any process that decreases the frequency, rate or extent of border cell delamination." [PMID:10822261]


id: GO:0030713
name: ovarian follicle cell stalk formation
namespace: biological_process
def:
  "Development of ovarian follicle cells to create the interfollicular stalks that connect the egg chambers of progressive developmental stages. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:10822261]


id: GO:0030715
name: oocyte growth in germarium-derived egg chamber
namespace: biological_process
def:
  "The increase in volume of an oocyte during the growth phase of the egg chamber, once the egg chamber has left the germarium. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238]


id: GO:0030716
name: oocyte fate determination
namespace: biological_process
def:
  "The process in which a cell becomes capable of differentiating autonomously into an oocyte cell regardless of its environment; upon determination, the cell fate cannot be reversed." [GOC:go_curators]


id: GO:0030717
name: karyosome formation
namespace: biological_process
def:
  "The chromosome organization process in which meiotic chromosomes in the oocyte nucleus cluster together to form a compact spherical structure called the karyosome." [PMID:11700288, PMID:18039935]


id: GO:0030718
name: germ-line stem cell population maintenance
namespace: biological_process
def:
  "Any process by which an organism or tissue maintains a population of germ-line stem cells." [ISBN:0879694238]


id: GO:0030719
name: P granule organization
namespace: biological_process
def:
  "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of polar granules, cytoplasmic, non-membranous RNA/protein complex aggregates in the primordial germ cells of many higher eukaryotes." [PMID:10851135, PMID:770367]


id: GO:0030720
name: oocyte localization involved in germarium-derived egg chamber formation
namespace: biological_process
def:
  "Directed movement of the oocyte, following its specification, from its original central position in the cyst to a posterior position relative to the nurse cells of the egg chamber, and its maintenance in this posterior location. This is the first sign of anterior-posterior asymmetry in the developing egg chamber." [GOC:mtg_sensu, PMID:10449356]


id: GO:0030721
name: spectrosome organization
namespace: biological_process
def:
  "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the spectrosome, a germline specific spherical organelle that is the precursor to the fusome." [PMID:11131529]


id: GO:0030722
name: establishment of oocyte nucleus localization involved in oocyte dorsal/ventral axis specification
namespace: biological_process
def:
  "The directed movement of the nucleus to a specific location within the cell during the establishment and maintenance of the dorsal/ventral axis of the oocyte. In the insect oocyte, for example, the nucleus is repositioned to a dorso-anterior position." [GOC:dph, GOC:mah, GOC:mtg_sensu, GOC:tb]


id: GO:0030723
name: ovarian fusome organization
namespace: biological_process
def:
  "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the fusome of ovarian cells, an organelle derived from the spectrosome. It anchors the mitotic spindle pole to provide orientation during cystoblast cell divisions." [GOC:dph, GOC:jl, GOC:mah, ISBN:0879694238]


id: GO:0030724
name: testicular fusome organization
namespace: biological_process
def:
  "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the fusome of testicular cells, an organelle derived from the spectrosome." [GOC:dph, GOC:jl, GOC:mah, ISBN:0879694238]


id: GO:0030725
name: germline ring canal formation
namespace: biological_process
def:
  "Assembly of the cytoplasmic bridges between developing spermatogonial or oogonial cysts." [ISBN:0879694238]


id: GO:0030726
name: male germline ring canal formation
namespace: biological_process
def:
  "Formation of the intercellular bridges that connect the germ-line cells of a male cyst." [ISBN:0879694238]


id: GO:0030727
name: germarium-derived female germ-line cyst formation
namespace: biological_process
def:
  "Formation, in a germarium, of a group of interconnected cells derived from a single female gonial founder cell (a cystoblast). The germarium is the most anterior portion of an insect ovariole. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:10370240, PMID:9442902]


id: GO:0030729
name: acetoacetate-CoA ligase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: acetoacetate + ATP + CoA = acetoacetyl-CoA + AMP + diphosphate + H(+)." [EC:6.2.1.16, RHEA:16120]


id: GO:0030730
name: sequestering of triglyceride
namespace: biological_process
def:
  "The process of binding or confining any triester of glycerol such that it is separated from other components of a biological system." [GOC:mah, ISBN:0198506732]


id: GO:0030731
name: guanidinoacetate N-methyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: S-adenosyl-L-methionine + guanidinoacetate = S-adenosyl-L-homocysteine + creatine + H(+)." [EC:2.1.1.2, RHEA:10659]


id: GO:0030732
name: methionine S-methyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: S-adenosyl-L-methionine + L-methionine = S-adenosyl-L-homocysteine + S-methyl-L-methionine." [EC:2.1.1.12]


id: GO:0030733
name: fatty acid O-methyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: S-adenosyl-L-methionine + a fatty acid = S-adenosyl-L-homocysteine + a fatty acid methyl ester." [EC:2.1.1.15]


id: GO:0030734
name: polysaccharide O-methyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: S-adenosyl-L-methionine + 1,4-N1-D-glucooligosaccharide = S-adenosyl-L-homocysteine + oligosaccharide containing 6-methyl-D-glucose units." [EC:2.1.1.18]


id: GO:0030735
name: carnosine N-methyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: S-adenosyl-L-methionine + carnosine = S-adenosyl-L-homocysteine + anserine + H(+)." [EC:2.1.1.22, RHEA:14208]


id: GO:0030736
name: phenol O-methyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: S-adenosyl-L-methionine + phenol = S-adenosyl-L-homocysteine + anisole + H(+)." [EC:2.1.1.25, RHEA:14812]


id: GO:0030737
name: iodophenol O-methyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 2-iodophenol + S-adenosyl-L-methionine = 1-iodo-2-methoxybenzene + S-adenosyl-L-homocysteine + H(+)." [EC:2.1.1.26, RHEA:14316]


id: GO:0030738
name: tyramine N-methyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: S-adenosyl-L-methionine + tyramine = N-methyltyramine + S-adenosyl-L-homocysteine + H(+)." [EC:2.1.1.27, RHEA:14868]


id: GO:0030739
name: O-demethylpuromycin O-methyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: S-adenosyl-L-methionine + O-demethylpuromycin = S-adenosyl-L-homocysteine + puromycin." [EC:2.1.1.38]


id: GO:0030740
name: inositol 3-methyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: S-adenosyl-L-methionine(1+) + myo-inositol = 1D-3-O-methyl-myo-inositol + S-adenosyl-L-homocysteine + H(+)." [EC:2.1.1.39, RHEA:18880]


id: GO:0030741
name: inositol 1-methyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: S-adenosyl-L-methionine(1+) + myo-inositol = 1D-1-O-methyl-myo-inositol + S-adenosyl-L-homocysteine + H(+)." [EC:2.1.1.40, RHEA:17568]


id: GO:0030742
name: GTP-dependent protein binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules) using energy from the hydrolysis of GTP." [GOC:go_curators]


id: GO:0030743
name: rRNA (adenosine-2'-O-)-methyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing a single residue of 2'-O-methyladenosine." [EC:2.1.1.66]


id: GO:0030744
name: luteolin O-methyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: S-adenosyl-L-methionine + luteolin = 4',5,7-trihydroxy-3'-methoxyflavone + S-adenosyl-L-homocysteine + H(+)." [EC:2.1.1.42, RHEA:14592]


id: GO:0030745
name: dimethylhistidine N-methyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: S-adenosyl-L-methionine + N-alpha,N-alpha-dimethyl-L-histidine = S-adenosyl-L-homocysteine + N-alpha,N-alpha,N-alpha-trimethyl-L-histidine." [EC:2.1.1.44]


id: GO:0030746
name: isoflavone 4'-O-methyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: S-adenosyl-L-methionine + isoflavone = S-adenosyl-L-homocysteine + 4'-O-methylisoflavone." [EC:2.1.1.46]


id: GO:0030747
name: indolepyruvate C-methyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: S-adenosyl-L-methionine + (indol-3-yl)pyruvate = S-adenosyl-L-homocysteine + (S)-3-(indol-3-yl)-2-oxobutanoate." [EC:2.1.1.47]


id: GO:0030748
name: amine N-methyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: S-adenosyl-L-methionine + an amine = S-adenosyl-L-homocysteine + a methylated amine." [EC:2.1.1.49]


id: GO:0030749
name: loganate O-methyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: S-adenosyl-L-methionine + loganate = S-adenosyl-L-homocysteine + loganin." [EC:2.1.1.50]


id: GO:0030750
name: putrescine N-methyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: S-adenosyl-L-methionine + putrescine = N-methylputrescine + S-adenosyl-L-homocysteine + H(+)." [EC:2.1.1.53, RHEA:15040]


id: GO:0030751
name: licodione 2'-O-methyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: S-adenosyl-L-methionine(1+) + licodione = 2'-O-methyllicodione + S-adenosyl-L-homocysteine + H(+)." [EC:2.1.1.65, RHEA:18524]


id: GO:0030752
name: 5-hydroxyfuranocoumarin 5-O-methyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: S-adenosyl-L-methionine + 5-hydroxyfuranocoumarin = S-adenosyl-L-homocysteine + 5-methoxyfuranocoumarin." [EC:2.1.1.69]


id: GO:0030753
name: 8-hydroxyfuranocoumarin 8-O-methyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: S-adenosyl-L-methionine + xanthotoxol = S-adenosyl-L-homocysteine + xanthotoxin. Xanthotoxol is also known as 8-hydroxyfuranocoumarin and xanthotoxin as 8-methoxyfuranocoumarin." [EC:2.1.1.70]


id: GO:0030754
name: apigenin 4'-O-methyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: S-adenosyl-L-methionine + 5,7,4'-trihydroxyflavone = S-adenosyl-L-homocysteine + 4'-methoxy-5,7-dihydroxyflavone." [EC:2.1.1.75]


id: GO:0030755
name: quercetin 3-O-methyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: S-adenosyl-L-methionine + 3,5,7,3',4'-pentahydroxyflavone = S-adenosyl-L-homocysteine + 3-methoxy-5,7,3',4'-tetrahydroxy-flavone." [EC:2.1.1.76]


id: GO:0030756
name: isoorientin 3'-O-methyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: S-adenosyl-L-methionine(1+) + isoorientin = S-adenosyl-L-homocysteine + H(+) + isoscoparin." [EC:2.1.1.78, RHEA:24099]


id: GO:0030757
name: 3-methylquercitin 7-O-methyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 3',4',5,7-tetrahydroxy-3-methoxyflavone + S-adenosyl-L-methionine(1+) = 3',4',5-trihydroxy-3,7-dimethoxyflavone + S-adenosyl-L-homocysteine." [EC:2.1.1.82, RHEA:16184]


id: GO:0030758
name: 3,7-dimethylquercitin 4'-O-methyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 3',4',5-trihydroxy-3,7-dimethoxyflavone + S-adenosyl-L-methionine(1+) = 3',5-dihydroxy-3,4',7-trimethoxyflavone + S-adenosyl-L-homocysteine + H(+)." [EC:2.1.1.83, RHEA:21835]


id: GO:0030759
name: methylquercetagetin 6-O-methyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 3',4',5,6-tetrahydroxy-3,7-dimethoxyflavone + S-adenosyl-L-methionine(1+) = 3',4',5-trihydroxy-3,6,7-trimethoxyflavone + S-adenosyl-L-homocysteine + H(+)." [EC:2.1.1.84, RHEA:18720]


id: GO:0030760
name: pyridine N-methyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: S-adenosyl-L-methionine(1+) + pyridine = N-methylpyridinium + S-adenosyl-L-homocysteine." [EC:2.1.1.87, RHEA:16896]


id: GO:0030761
name: 8-hydroxyquercitin 8-O-methyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 3,3',4',5,7,8-hexahydroxyflavone + S-adenosyl-L-methionine(1+) = 3,3',4',5,7-pentahydroxy-8-methoxyflavone + S-adenosyl-L-homocysteine + H(+)." [EC:2.1.1.88, RHEA:16596]


id: GO:0030762
name: tetrahydrocolumbamine 2-O-methyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: (S)-tetrahydrocolumbamine + S-adenosyl-L-methionine(1+) = S-adenosyl-L-homocysteine + H(+) + tetrahydropalmatine." [EC:2.1.1.89, RHEA:22539]


id: GO:0030763
name: isobutyraldoxime O-methyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 2-methylpropanal oxime + S-adenosyl-L-methionine = 2-methylpropanal O-methyloxime + S-adenosyl-L-homocysteine + H(+)." [EC:2.1.1.91, RHEA:10999]


id: GO:0030766
name: 11-O-demethyl-17-O-deacetylvindoline O-methyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: S-adenosyl-L-methionine + 11-O-demethyl-17-O-deacetylvindoline = S-adenosyl-L-homocysteine + 17-O-deacetylvindoline." [EC:2.1.1.94]


id: GO:0030767
name: 3-hydroxyanthranilate 4-C-methyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 3-hydroxyanthranilate + S-adenosyl-L-methionine = 3-hydroxy-4-methylanthranilate + S-adenosyl-L-homocysteine + H(+)." [EC:2.1.1.97, RHEA:17836]


id: GO:0030768
name: 16-methoxy-2,3-dihydro-3-hydroxytabersonine N-methyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: (3R)-3-hydroxy-16-methoxy-2,3-dihydrotabersonine + S-adenosyl-L-methionine = S-adenosyl-L-homocysteine + deacetoxyvindoline + H(+)." [EC:2.1.1.99, RHEA:11339]


id: GO:0030769
name: macrocin O-methyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: S-adenosyl-L-methionine(1+) + macrocin = S-adenosyl-L-homocysteine + H(+) + tylosin." [EC:2.1.1.101, RHEA:17272]


id: GO:0030770
name: demethylmacrocin O-methyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: S-adenosyl-L-methionine(1+) + demethylmacrocin = S-adenosyl-L-homocysteine + H(+) + macrocin." [EC:2.1.1.102, RHEA:17576]


id: GO:0030771
name: N-benzoyl-4-hydroxyanthranilate 4-O-methyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: N-benzoyl-4-hydroxyanthranilate + S-adenosyl-L-methionine(1+) = N-benzoyl-4-methoxyanthranilate + S-adenosyl-L-homocysteine + H(+)." [EC:2.1.1.105, RHEA:17408]


id: GO:0030772
name: tryptophan 2-C-methyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: S-adenosyl-L-methionine(1+) + L-tryptophan = S-adenosyl-L-homocysteine + L-2-methyltryptophan + H(+)." [EC:2.1.1.106, RHEA:17324]


id: GO:0030773
name: 6-hydroxymellein O-methyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 6-hydroxymellein + S-adenosyl-L-methionine = 6-methoxymellein + S-adenosyl-L-homocysteine + H(+)." [EC:2.1.1.108, RHEA:15204]


id: GO:0030774
name: anthranilate N-methyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: S-adenosyl-L-methionine + anthranilate = N-methylanthranilate + S-adenosyl-L-homocysteine + H(+)." [EC:2.1.1.111, RHEA:12183]


id: GO:0030775
name: glucuronoxylan 4-O-methyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: S-adenosyl-L-methionine + glucuronoxylan D-glucuronate = S-adenosyl-L-homocysteine + glucuronoxylan 4-O-methyl-D-glucuronate." [EC:2.1.1.112]


id: GO:0030776
name: (RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline N-methyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: S-adenosyl-L-methionine + (RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline = S-adenosyl-L-homocysteine + N-methyl-(RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline." [EC:2.1.1.115]


id: GO:0030777
name: (S)-scoulerine 9-O-methyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: (S)-scoulerine + S-adenosyl-L-methionine(1+) = (S)-tetrahydrocolumbamine + S-adenosyl-L-homocysteine + H(+)." [EC:2.1.1.117, RHEA:23811]


id: GO:0030778
name: columbamine O-methyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: S-adenosyl-L-methionine + columbamine = S-adenosyl-L-homocysteine + H(+) + palmatine." [EC:2.1.1.118, RHEA:15376]


id: GO:0030779
name: 10-hydroxydihydrosanguinarine 10-O-methyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 10-hydroxydihydrosanguinarine + S-adenosyl-L-methionine(1+) = S-adenosyl-L-homocysteine + dihydrochelirubine + H(+)." [EC:2.1.1.119, RHEA:18544]


id: GO:0030780
name: 12-hydroxydihydrochelirubine 12-O-methyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 12-hydroxydihydrochelirubine + S-adenosyl-L-methionine(1+) = S-adenosyl-L-homocysteine + dihydromacarpine + H(+)." [EC:2.1.1.120, RHEA:21095]


id: GO:0030781
name: 6-O-methylnorlaudanosoline 5'-O-methyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: S-adenosyl-L-methionine + 6-O-methylnorlaudanosoline = S-adenosyl-L-homocysteine + nororientaline." [EC:2.1.1.121]


id: GO:0030782
name: (S)-tetrahydroprotoberberine N-methyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: S-adenosyl-L-methionine + (S)-7,8,13,14-tetrahydroprotoberberine = S-adenosyl-L-homocysteine + cis-N-methyl-(S)-7,8,13,14-tetrahydroprotoberberine." [EC:2.1.1.122]


id: GO:0030783
name: [cytochrome c]-methionine S-methyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: S-adenosyl-L-methionine + [cytochrome c]-methionine = S-adenosyl-L-homocysteine + [cytochrome c]-S-methyl-methionine." [EC:2.1.1.123]


id: GO:0030784
name: 3'-hydroxy-N-methyl-(S)-coclaurine 4'-O-methyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: S-adenosyl-L-methionine + 3'-hydroxy-N-methyl-(S)-coclaurine = S-adenosyl-L-homocysteine + (S)-reticuline." [EC:2.1.1.116]


id: GO:0030785
name: [ribulose-bisphosphate carboxylase]-lysine N-methyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: S-adenosyl-L-methionine + [ribulose-1,5-bisphosphate carboxylase]-lysine = S-adenosyl-L-homocysteine + [ribulose-1,5-bisphosphate carboxylase]-N6-methyl-L-lysine." [EC:2.1.1.127]


id: GO:0030786
name: (RS)-norcoclaurine 6-O-methyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: S-adenosyl-L-methionine + (RS)-norcoclaurine = S-adenosyl-L-homocysteine + (RS)-coclaurine." [EC:2.1.1.128]


id: GO:0030787
name: inositol 4-methyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: S-adenosyl-L-methionine(1+) + myo-inositol = 1D-4-O-methyl-myo-inositol + S-adenosyl-L-homocysteine + H(+)." [EC:2.1.1.129, RHEA:23251]


id: GO:0030788
name: precorrin-2 C20-methyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: S-adenosyl-L-methionine + precorrin-2 = S-adenosyl-L-homocysteine + H(+) + precorrin-3A." [EC:2.1.1.130, RHEA:16844]


id: GO:0030789
name: precorrin-3B C17-methyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: S-adenosyl-L-methionine + precorrin-3B = S-adenosyl-L-homocysteine + precorrin 4." [EC:2.1.1.131]


id: GO:0030790
name: chlorophenol O-methyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: S-adenosyl-L-methionine + trichlorophenol = S-adenosyl-L-homocysteine + trichloroanisole." [EC:2.1.1.136]


id: GO:0030791
name: arsenite methyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: S-adenosyl-L-methionine + arsenite = S-adenosyl-L-homocysteine + methylarsonate." [EC:2.1.1.137]


id: GO:0030792
name: methylarsonite methyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: S-adenosyl-L-methionine + methylarsonite = S-adenosyl-L-homocysteine + dimethylarsinate." [EC:2.1.1.138]


id: GO:0030793
name: 3'-demethylstaurosporine O-methyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 3'-demethylstaurosporine + S-adenosyl-L-methionine = S-adenosyl-L-homocysteine + H(+) + staurosporine." [EC:2.1.1.139, RHEA:11699]


id: GO:0030794
name: (S)-coclaurine-N-methyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: S-adenosyl-L-methionine + (S)-coclaurine = S-adenosyl-L-homocysteine + (S)-N-methylcoclaurine." [EC:2.1.1.140]


id: GO:0030795
name: jasmonate O-methyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: S-adenosyl-L-methionine + jasmonate = S-adenosyl-L-homocysteine + methyljasmonate." [EC:2.1.1.141]


id: GO:0030796
name: cycloartenol 24-C-methyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: S-adenosyl-L-methionine + cycloartenol = (24R)-24-methylcycloart-25-en-3beta-ol + S-adenosyl-L-homocysteine + H(+)." [EC:2.1.1.142, RHEA:13140]


id: GO:0030797
name: 24-methylenesterol C-methyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: 24-methylidenelophenol + S-adenosyl-L-methionine(1+) = (Z)-24-ethylidenelophenol + S-adenosyl-L-homocysteine + H(+)." [EC:2.1.1.143, RHEA:21047]


id: GO:0030798
name: trans-aconitate 2-methyltransferase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: S-adenosyl-L-methionine + trans-aconitate = (E)-3-(methoxycarbonyl)pent-2-enedioate + S-adenosyl-L-homocysteine." [EC:2.1.1.144, RHEA:14972]


id: GO:0030799
name: regulation of cyclic nucleotide metabolic process
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving cyclic nucleotides." [GOC:mah]


id: GO:0030800
name: negative regulation of cyclic nucleotide metabolic process
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving cyclic nucleotides." [GOC:mah]


id: GO:0030801
name: positive regulation of cyclic nucleotide metabolic process
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving cyclic nucleotides." [GOC:mah]


id: GO:0030802
name: regulation of cyclic nucleotide biosynthetic process
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cyclic nucleotides." [GOC:mah]


id: GO:0030803
name: negative regulation of cyclic nucleotide biosynthetic process
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cyclic nucleotides." [GOC:mah]


id: GO:0030804
name: positive regulation of cyclic nucleotide biosynthetic process
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cyclic nucleotides." [GOC:mah]


id: GO:0030805
name: regulation of cyclic nucleotide catabolic process
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of cyclic nucleotides." [GOC:mah]


id: GO:0030806
name: negative regulation of cyclic nucleotide catabolic process
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of chemical reactions and pathways resulting in the breakdown of cyclic nucleotides." [GOC:mah]


id: GO:0030807
name: positive regulation of cyclic nucleotide catabolic process
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of chemical reactions and pathways resulting in the breakdown of cyclic nucleotides." [GOC:mah]


id: GO:0030808
name: regulation of nucleotide biosynthetic process
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of nucleotides." [GOC:mah]


id: GO:0030809
name: negative regulation of nucleotide biosynthetic process
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of nucleotides." [GOC:mah]


id: GO:0030810
name: positive regulation of nucleotide biosynthetic process
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of nucleotides." [GOC:mah]


id: GO:0030811
name: regulation of nucleotide catabolic process
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of nucleotides." [GOC:mah]


id: GO:0030812
name: negative regulation of nucleotide catabolic process
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of nucleotides." [GOC:mah]


id: GO:0030813
name: positive regulation of nucleotide catabolic process
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of nucleotides." [GOC:mah]


id: GO:0030814
name: regulation of cAMP metabolic process
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate)." [GOC:mah]


id: GO:0030815
name: negative regulation of cAMP metabolic process
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate)." [GOC:mah]


id: GO:0030816
name: positive regulation of cAMP metabolic process
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate)." [GOC:mah]


id: GO:0030817
name: regulation of cAMP biosynthetic process
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate)." [GOC:mah]


id: GO:0030818
name: negative regulation of cAMP biosynthetic process
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate)." [GOC:mah]


id: GO:0030819
name: positive regulation of cAMP biosynthetic process
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate)." [GOC:mah]


id: GO:0030820
name: regulation of cAMP catabolic process
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate)." [GOC:mah]


id: GO:0030821
name: negative regulation of cAMP catabolic process
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate)." [GOC:mah]


id: GO:0030822
name: positive regulation of cAMP catabolic process
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate)." [GOC:mah]


id: GO:0030823
name: regulation of cGMP metabolic process
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving cGMP." [GOC:mah]


id: GO:0030824
name: negative regulation of cGMP metabolic process
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving cGMP." [GOC:mah]


id: GO:0030825
name: positive regulation of cGMP metabolic process
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving cGMP." [GOC:mah]


id: GO:0030826
name: regulation of cGMP biosynthetic process
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cGMP." [GOC:mah]


id: GO:0030827
name: negative regulation of cGMP biosynthetic process
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cGMP." [GOC:mah]


id: GO:0030828
name: positive regulation of cGMP biosynthetic process
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cGMP." [GOC:mah]


id: GO:0030829
name: regulation of cGMP catabolic process
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of cGMP." [GOC:mah]


id: GO:0030830
name: negative regulation of cGMP catabolic process
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of cGMP." [GOC:mah]


id: GO:0030831
name: positive regulation of cGMP catabolic process
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of cGMP." [GOC:mah]


id: GO:0030833
name: regulation of actin filament polymerization
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of the assembly of actin filaments by the addition of actin monomers to a filament." [GOC:mah]


id: GO:0030834
name: regulation of actin filament depolymerization
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of the disassembly of actin filaments by the removal of actin monomers from a filament." [GOC:mah]


id: GO:0030835
name: negative regulation of actin filament depolymerization
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of actin depolymerization." [GOC:mah]


id: GO:0030836
name: positive regulation of actin filament depolymerization
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of actin depolymerization." [GOC:mah]


id: GO:0030837
name: negative regulation of actin filament polymerization
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of actin polymerization." [GOC:mah]


id: GO:0030838
name: positive regulation of actin filament polymerization
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of actin polymerization." [GOC:mah]


id: GO:0030839
name: regulation of intermediate filament polymerization
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of the assembly of intermediate filaments by the addition of monomers to a filament." [GOC:mah]


id: GO:0030840
name: negative regulation of intermediate filament polymerization
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of intermediate filament polymerization." [GOC:mah]


id: GO:0030841
name: positive regulation of intermediate filament polymerization
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of intermediate filament polymerization." [GOC:mah]


id: GO:0030842
name: regulation of intermediate filament depolymerization
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of the disassembly of intermediate filaments by the removal of monomers from a filament." [GOC:mah]


id: GO:0030843
name: negative regulation of intermediate filament depolymerization
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of intermediate filament depolymerization." [GOC:mah]


id: GO:0030844
name: positive regulation of intermediate filament depolymerization
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of intermediate filament depolymerization." [GOC:mah]


id: GO:0030845
name: phospholipase C-inhibiting G-protein coupled receptor signaling pathway
namespace: biological_process
def:
  "A G-protein coupled receptor signaling pathway which proceeds with inhibition of phospholipase C (PLC) activity and a subsequent decrease in the levels of cellular inositol trisphosphate (IP3) and diacylglycerol (DAG)." [GOC:dph, GOC:mah, GOC:signaling, GOC:tb, PMID:8280098]


id: GO:0030846
name: termination of RNA polymerase II transcription, poly(A)-coupled
namespace: biological_process
def:
  "The process in which transcription of polyadenylated RNA polymerase II transcripts is terminated; cleavage and polyadenylylation of the mRNA 3' end is coupled to transcription termination." [GOC:txnOH, PMID:12944462, PMID:18679429]


id: GO:0030847
name: termination of RNA polymerase II transcription, exosome-dependent
namespace: biological_process
def:
  "The process in which transcription of nonpolyadenylated RNA polymerase II transcripts is terminated; coupled to the maturation of the RNA 3'-end." [GOC:txnOH, PMID:12944462, PMID:18679429]


id: GO:0030848
name: threo-3-hydroxyaspartate ammonia-lyase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: (3S)-3-hydroxy-L-aspartate = NH(4)(+) + oxaloacetate." [EC:4.3.1.16, RHEA:12427]


id: GO:0030850
name: prostate gland development
namespace: biological_process
def:
  "The process whose specific outcome is the progression of the prostate gland over time, from its formation to the mature structure. The prostate gland is a partly muscular, partly glandular body that is situated near the base of the mammalian male urethra and secretes an alkaline viscid fluid which is a major constituent of the ejaculatory fluid." [PMID:11839751]


id: GO:0030851
name: granulocyte differentiation
namespace: biological_process
def:
  "The process in which a myeloid precursor cell acquires the specialized features of a granulocyte. Granulocytes are a class of leukocytes characterized by the presence of granules in their cytoplasm. These cells are active in allergic immune reactions such as arthritic inflammation and rashes. This class includes basophils, eosinophils and neutrophils." [GOC:ecd, http://life.nthu.edu.tw/~g864204/dict-search1.htm]


id: GO:0030852
name: regulation of granulocyte differentiation
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of granulocyte differentiation." [GOC:mah]


id: GO:0030853
name: negative regulation of granulocyte differentiation
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of granulocyte differentiation." [GOC:mah]


id: GO:0030854
name: positive regulation of granulocyte differentiation
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of granulocyte differentiation." [GOC:mah]


id: GO:0030855
name: epithelial cell differentiation
namespace: biological_process
def:
  "The process in which a relatively unspecialized cell acquires specialized features of an epithelial cell, any of the cells making up an epithelium." [GOC:ecd, PMID:11839751]


id: GO:0030856
name: regulation of epithelial cell differentiation
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of epithelial cell differentiation." [GOC:mah]


id: GO:0030857
name: negative regulation of epithelial cell differentiation
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of epithelial cell differentiation." [GOC:mah]


id: GO:0030858
name: positive regulation of epithelial cell differentiation
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of epithelial cell differentiation." [GOC:mah]


id: GO:0030859
name: polarized epithelial cell differentiation
namespace: biological_process
def:
  "The process in which a relatively unspecialized cell acquires specialized features of a polarized epithelial cell. The polarized epithelial cell can be any of the cells within an epithelium where the epithelial sheet is oriented with respect to the planar axis." [GOC:mah]


id: GO:0030860
name: regulation of polarized epithelial cell differentiation
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of polarized epithelial cell differentiation." [GOC:mah]


id: GO:0030861
name: negative regulation of polarized epithelial cell differentiation
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of polarized epithelial cell differentiation." [GOC:mah]


id: GO:0030862
name: positive regulation of polarized epithelial cell differentiation
namespace: biological_process
def:
  "Any process that activates or increases the rate or extent of polarized epithelial cell differentiation." [GOC:mah]


id: GO:0030864
name: cortical actin cytoskeleton
namespace: cellular_component
def:
  "The portion of the actin cytoskeleton, comprising filamentous actin and associated proteins, that lies just beneath the plasma membrane." [GOC:mah]


id: GO:0030865
name: cortical cytoskeleton organization
namespace: biological_process
def:
  "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures in the cell cortex, i.e. just beneath the plasma membrane." [GOC:dph, GOC:jl, GOC:mah]


id: GO:0030866
name: cortical actin cytoskeleton organization
namespace: biological_process
def:
  "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of actin-based cytoskeletal structures in the cell cortex, i.e. just beneath the plasma membrane." [GOC:dph, GOC:jl, GOC:mah]


id: GO:0030869
name: RENT complex
namespace: cellular_component
def:
  "A protein complex that mediates transcriptional silencing at the rDNA locus (the name derives from regulator of nucleolar silencing and telophase). In Saccharomyces the complex contains Net1p, Sir2p, Cdc14p, and at least one more subunit." [PMID:12196389]


id: GO:0030870
name: Mre11 complex
namespace: cellular_component
def:
  "Trimeric protein complex that possesses endonuclease activity; involved in meiotic recombination, DNA repair and checkpoint signaling. In Saccharomyces cerevisiae, the complex comprises Mre11p, Rad50p, and Xrs2p; complexes identified in other species generally contain proteins orthologous to the Saccharomyces cerevisiae proteins." [GOC:mah, GOC:vw, PMID:11988766, PMID:17674145]


id: GO:0030874
name: nucleolar chromatin
namespace: cellular_component
def:
  "The portion of nuclear chromatin associated with the nucleolus; includes the DNA encoding the ribosomal RNA." [GOC:mah]


id: GO:0030875
name: rDNA protrusion
namespace: cellular_component
def:
  "Any of the tandem arrays of rDNA localized at the periphery of the nucleus and protruding into the nucleolus, and associated proteins. May be visible as a single or double spot by DAPI staining." [PMID:1629244]


id: GO:0030877
name: beta-catenin destruction complex
namespace: cellular_component
def:
  "A cytoplasmic protein complex containing glycogen synthase kinase-3-beta (GSK-3-beta), the adenomatous polyposis coli protein (APC), and the scaffolding protein axin, among others; phosphorylates beta-catenin, targets it for degradation by the proteasome." [PMID:14600025]


id: GO:0030878
name: thyroid gland development
namespace: biological_process
def:
  "The process whose specific outcome is the progression of the thyroid gland over time, from its formation to the mature structure. The thyroid gland is an endoderm-derived gland that produces thyroid hormone." [GOC:dgh]


id: GO:0030879
name: mammary gland development
namespace: biological_process
def:
  "The process whose specific outcome is the progression of the mammary gland over time, from its formation to the mature structure. The mammary gland is a large compound sebaceous gland that in female mammals is modified to secrete milk. Its development starts with the formation of the mammary line and ends as the mature gland cycles between nursing and weaning stages." [PMID:9576833]


id: GO:0030880
name: RNA polymerase complex
namespace: cellular_component
def:
  "Any complex that possesses RNA polymerase activity; generally comprises a catalytic subunit and one or more additional subunits." [GOC:mah]


id: GO:0030883
name: endogenous lipid antigen binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with an endogenous cellular lipid antigen." [PMID:14500461]


id: GO:0030884
name: exogenous lipid antigen binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with an exogenous lipid antigen (examples include microbial lipids and glycolipids)." [PMID:14500461]


id: GO:0030886
name: negative regulation of myeloid dendritic cell activation
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of myeloid dendritic cell activation." [GOC:mah]


id: GO:0030887
name: positive regulation of myeloid dendritic cell activation
namespace: biological_process
def:
  "Any process that stimulates, induces or increases the rate of myeloid dendritic cell activation." [GOC:mah]


id: GO:0030891
name: VCB complex
namespace: cellular_component
def:
  "A protein complex that possesses ubiquitin ligase activity; the complex is usually pentameric; for example, in mammals the subunits are pVHL, elongin B, elongin C, cullin-2 (Cul2), and Rbx1." [GOC:mah, PMID:11865071]


id: GO:0030892
name: mitotic cohesin complex
namespace: cellular_component
def:
  "A cohesin complex that mediates sister chromatid cohesion during mitosis; has a subunit composition distinct from that of the meiotic cohesin complex." [GOC:mah, PMID:12750522]


id: GO:0030893
name: meiotic cohesin complex
namespace: cellular_component
def:
  "A cohesin complex that mediates sister chromatid cohesion during meiosis; has a subunit composition distinct from that of the mitotic cohesin complex." [GOC:mah, PMID:12750522]


id: GO:0030894
name: replisome
namespace: cellular_component
def:
  "A multi-component enzymatic machine at the replication fork which mediates DNA replication. Includes DNA primase, one or more DNA polymerases, DNA helicases, and other proteins." [GOC:mah, GOC:vw]


id: GO:0030895
name: apolipoprotein B mRNA editing enzyme complex
namespace: cellular_component
def:
  "Protein complex that mediates editing of the mRNA encoding apolipoprotein B; catalyzes the deamination of C to U (residue 6666 in the human mRNA). Contains a catalytic subunit, APOBEC-1, and other proteins (e.g. human ASP; rat ASP and KSRP)." [PMID:10781591]


id: GO:0030896
name: checkpoint clamp complex
namespace: cellular_component
def:
  "Conserved heterotrimeric complex of PCNA-like proteins that is loaded onto DNA at sites of DNA damage." [PMID:12531008]


id: GO:0030897
name: HOPS complex
namespace: cellular_component
def:
  "A multimeric protein complex that associates with the vacuolar membrane, late endosomal (multivesicular body) and lysosomal membranes. HOPS is a tethering complex involved in vesicle fusion." [PMID:10944212, PMID:23645161]


id: GO:0030898
name: actin-dependent ATPase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: ATP + H2O = ADP + phosphate. This reaction requires the presence of an actin filament to accelerate release of ADP and phosphate." [GOC:mah]


id: GO:0030899
name: calcium-dependent ATPase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: ATP + H2O = ADP + phosphate. This reaction requires the presence of calcium ion (Ca2+)." [GOC:mah]


id: GO:0030900
name: forebrain development
namespace: biological_process
def:
  "The process whose specific outcome is the progression of the forebrain over time, from its formation to the mature structure. The forebrain is the anterior of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes especially the cerebral hemispheres, the thalamus, and the hypothalamus and especially in higher vertebrates is the main control center for sensory and associative information processing, visceral functions, and voluntary motor functions)." [http://www2.merriam-webster.com/cgi-bin/mwmednlm?book=Medical&va=forebrain]


id: GO:0030901
name: midbrain development
namespace: biological_process
def:
  "The process whose specific outcome is the progression of the midbrain over time, from its formation to the mature structure. The midbrain is the middle division of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes a ventral part containing the cerebral peduncles and a dorsal tectum containing the corpora quadrigemina and that surrounds the aqueduct of Sylvius connecting the third and fourth ventricles)." [http://www2.merriam-webster.com/cgi-bin/mwmednlm?book=Medical&va=midbrain]


id: GO:0030902
name: hindbrain development
namespace: biological_process
def:
  "The process whose specific outcome is the progression of the hindbrain over time, from its formation to the mature structure. The hindbrain is the posterior of the three primary divisions of the developing chordate brain, or the corresponding part of the adult brain (in vertebrates, includes the cerebellum, pons, and medulla oblongata and controls the autonomic functions and equilibrium)." [http://www2.merriam-webster.com/cgi-bin/mwmednlm?book=Medical&va=hindbrain]


id: GO:0030903
name: notochord development
namespace: biological_process
def:
  "The process whose specific outcome is the progression of the notochord over time, from its formation to the mature structure. The notochord is a mesoderm-derived structure located ventral of the developing nerve cord. In vertebrates, the notochord serves as a core around which other mesodermal cells form the vertebrae. In the most primitive chordates, which lack vertebrae, the notochord persists as a substitute for a vertebral column." [GOC:dgh]


id: GO:0030904
name: retromer complex
namespace: cellular_component
def:
  "A conserved hetero-pentameric membrane-associated complex involved in retrograde transport from endosomes to the Golgi apparatus. The budding yeast retromer comprises Vps35p, Vps29p, Vps26p, Vps5p, and Vps17p. The mammalian complex shows slight variation in composition compared to yeast, and comprises SNX1 or SNX2, SNX5 or SNX6, VPS26A or VPS26B, VPS29, and VPS35." [GOC:bf, PMID:26220253, PMID:9700157]


id: GO:0030905
name: retromer, tubulation complex
namespace: cellular_component
def:
  "The dimeric subcomplex of the retromer, believed to be peripherally associated with the membrane. This dimeric complex is responsible for remodelling endosomal membranes to form a tube-structure to which cargo molecules are selected for recycling. The budding yeast complex comprises Vps5p and Vps17p, and may contain multiple copies of a Vps5p/Vps17p dimer. The mammalian complex contains SNX1 or SNX2 dimerized with SNX5 or SNX6." [GOC:bf, PMID:26220253, PMID:9700157]


id: GO:0030906
name: retromer, cargo-selective complex
namespace: cellular_component
def:
  "The trimeric subcomplex of the retromer, believed to be closely associated with the membrane. This trimeric complex is responsible for recognizing and binding to cargo molecules. The complex comprises three Vps proteins in both yeast and mammalian cells: Vps35p, Vps29p, and Vps26p in yeast, and VPS35, VPS29 and VPS26A or VPS26B in mammals." [GOC:bf, PMID:11102511, PMID:26220253, PMID:9700157]


id: GO:0030907
name: MBF transcription complex
namespace: cellular_component
def:
  "A protein complex that binds to the Mlu1 cell cycle box (MCB) promoter element, consensus sequence ACGCGN, and is involved in regulation of transcription during the G1/S transition of the cell cycle. In Saccharomyces, the complex contains a heterodimer of the DNA binding protein Mbp1p and the activator Swi4p, and is associated with additional proteins known as Nrm1p, Msa1p, and Msa2p; in Schizosaccharomyces the complex contains Res1p, Res2p, and Cdc10p." [GOC:mah, PMID:11206552, PMID:15838511, PMID:18160399, PMID:9343385]


id: GO:0030909
name: non-intein-mediated protein splicing
namespace: biological_process
def:
  "The post-translational removal of peptide sequences from within a protein sequence, by a process not involving inteins." [GOC:mah]


id: GO:0030910
name: olfactory placode formation
namespace: biological_process
def:
  "The formation of a thickening of the neural ectoderm in the head region of the vertebrate embryo which develops into the olfactory region of the nasal cavity." [GOC:dgh]


id: GO:0030911
name: TPR domain binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with a tetratricopeptide repeat (TPR) domain of a protein, the consensus sequence of which is defined by a pattern of small and large hydrophobic amino acids and a structure composed of helices." [GOC:mah]


id: GO:0030912
name: response to deep water
namespace: biological_process
def:
  "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a deep water stimulus, being immersed in standing deep water throughout the life cycle." [GOC:mah]


id: GO:0030913
name: paranodal junction assembly
namespace: biological_process
def:
  "Formation of the junction between an axon and the glial cell that forms the myelin sheath. Paranodal junctions form at each paranode, i.e. at the ends of the unmyelinated nodes of Ranvier." [PMID:14715942]


id: GO:0030914
name: STAGA complex
namespace: cellular_component
def:
  "A large multiprotein complex that possesses histone acetyltransferase and is involved in regulation of transcription. The composition is similar to that of the SAGA complex; for example, the human complex contains the transcription-transformation cofactor TRRAP, hGCN5L acetylase, novel human ADA-like and SPT-like cofactors, and a subset of TAFs." [PMID:11564863]


id: GO:0030915
name: Smc5-Smc6 complex
namespace: cellular_component
def:
  "A conserved complex that contains a heterodimer of SMC proteins (Smc5p and Smc6p, or homologs thereof) and several other proteins, and is involved in DNA repair and maintaining cell cycle arrest following DNA damage. In S. cerevisiae, this is an octameric complex called Mms21-Smc5-Smc6 complex, with at least five of its subunits conserved in fission yeast and humans." [GOC:rb, PMID:14701739]


id: GO:0030916
name: otic vesicle formation
namespace: biological_process
def:
  "The process resulting in the transition of the otic placode into the otic vesicle, a transient embryonic structure formed during development of the vertebrate inner ear." [GOC:dgh]


id: GO:0030917
name: midbrain-hindbrain boundary development
namespace: biological_process
def:
  "The process whose specific outcome is the progression of the midbrain-hindbrain boundary over time, from its formation to the mature structure. The midbrain-hindbrain domain of the embryonic brain is comprised of the mesencephalic vesicle and the first rhombencephalic vesicle at early somitogenesis stages." [GOC:dgh]


id: GO:0030919
name: peptidyl-serine O-acetylation
namespace: biological_process
def:
  "The acetylation of peptidyl-serine to form peptidyl-O-acetyl-L-serine." [PMID:489587, PMID:7309355, RESID:AA0364]


id: GO:0030921
name: peptidyl-tyrosine dehydrogenation to form (Z)-2,3-didehydrotyrosine
namespace: biological_process
def:
  "The oxidation of the C alpha-C beta bond of peptidyl-tyrosine to form peptidyl-(Z)-2,3-didehydrotyrosine coupled with cyclization of neighboring residues." [PMID:9631087, RESID:AA0183]


id: GO:0030922
name: peptidyl-tyrosine dehydrogenation to form (E)-2,3-didehydrotyrosine
namespace: biological_process
def:
  "The oxidation of the C alpha-C beta bond of peptidyl-tyrosine to form peptidyl-(E)-2,3-didehydrotyrosine coupled with cyclization of neighboring residues." [PMID:12623015, RESID:AA0365]


id: GO:0030923
name: metal incorporation into metallo-oxygen cluster
namespace: biological_process
def:
  "The formation of a cluster of several metal atoms, including manganese or calcium, with one or more bridging (mu-bond) oxygen atoms; amino acids residues in proteins that may ligate the metal oxygen cluster are histidine, aspartate, and glutamate." [GOC:jsg]


id: GO:0030926
namespace: biological_process
name:
  calcium incorporation into metallo-oxygen cluster via bis-L-aspartato tris-L-glutamato L-histidino calcium tetramanganese tetroxide

def:
  "The incorporation of calcium into a 4Mn-Ca-4O complex by bis-L-aspartato tris-L-glutamato L-histidino calcium tetramanganese tetroxide as in the photosystem II catalytic site." [PMID:14764885, RESID:AA0366]


id: GO:0030927
namespace: biological_process
name:
  manganese incorporation into metallo-oxygen cluster via bis-L-aspartato tris-L-glutamato L-histidino calcium tetramanganese tetroxide

def:
  "The incorporation of manganese into a 4Mn-Ca-4O complex by bis-L-aspartato tris-L-glutamato L-histidino calcium tetramanganese tetroxide as in the photosystem II catalytic site." [PMID:14764885, RESID:AA0366]


id: GO:0030929
name: ADPG pyrophosphorylase complex
namespace: cellular_component
def:
  "Complex that possesses ADPG pyrophosphorylase activity. In all organisms where it has been found, the complex is a tetramer. In bacteria, it is a homotetramer. In plants, the complex is a heterotetramer composed small and large subunits." [GOC:tb, PMID:9680965]


id: GO:0030930
name: homotetrameric ADPG pyrophosphorylase complex
namespace: cellular_component
def:
  "A protein complex composed of four identical subunits that possesses ADPG pyrophosphorylase activity. Examples of this component are found in Bacterial species." [GOC:mah, GOC:mtg_sensu]


id: GO:0030931
name: heterotetrameric ADPG pyrophosphorylase complex
namespace: cellular_component
def:
  "A protein complex composed of four different subunits that possesses ADPG pyrophosphorylase activity. An example of this process is found in Mus musculus." [GOC:mah, GOC:mtg_sensu]


id: GO:0030934
name: anchoring collagen complex
namespace: cellular_component
def:
  "Any collagen complex which links one collagen assembly, such as a collagen fibril or sheet, to other structures." [ISBN:0721639976]


id: GO:0030937
name: collagen type XVII trimer
namespace: cellular_component
def:
  "A collagen homotrimer of alpha1(XVII) chains; type XVII collagen triple helices span the plasma membrane and associate with hemidesmosomes and the basal lamina where they bind laminin." [ISBN:0721639976, PMID:19693541, PMID:21421911]


id: GO:0030939
name: obsolete response to long-day photoperiod
namespace: biological_process
def:
  "OBSOLETE. A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a photoperiod, an intermittent cycle of light (day) and dark (night) photoperiod regimes, with the light phase being longer than the dark." [GOC:pj]


id: GO:0030940
name: obsolete response to short-day photoperiod
namespace: biological_process
def:
  "OBSOLETE. A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a photoperiod, an intermittent cycle of light (day) and dark (night) photoperiod regimes, with the dark phase being longer than the light." [GOC:pj]


id: GO:0030941
name: chloroplast targeting sequence binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with a chloroplast targeting sequence, a specific peptide sequence that acts as a signal to localize the protein within the chloroplast." [GOC:mah]


id: GO:0030942
name: endoplasmic reticulum signal peptide binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with an endoplasmic reticulum signal peptide, a specific peptide sequence that acts as a signal to localize the protein within the endoplasmic reticulum." [GOC:mah]


id: GO:0030943
name: mitochondrion targeting sequence binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with a mitochondrion targeting sequence, a specific peptide sequence that acts as a signal to localize the protein within the mitochondrion." [GOC:mah]


id: GO:0030944
name: DDEL sequence binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with a KDEL sequence, the C terminus tetrapeptide sequence Asp-Asp-Glu-Leu found in proteins that are to be retained in the endoplasmic reticulum." [GOC:mah]


id: GO:0030945
name: protein tyrosine phosphatase activity, via thiol-phosphate intermediate
namespace: molecular_function
def:
  "The catalysis of phosphate removal from a phosphotyrosine using cysteine as a nucleophile and proceed by means of a thiol-phosphate intermediate." [GOC:hjd]


id: GO:0030946
name: protein tyrosine phosphatase activity, metal-dependent
namespace: molecular_function
def:
  "Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate. This reaction requires metal ions." [GOC:mah]


id: GO:0030947
name: regulation of vascular endothelial growth factor receptor signaling pathway
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of vascular endothelial growth factor receptor signaling pathway activity." [GOC:dgh]


id: GO:0030948
name: negative regulation of vascular endothelial growth factor receptor signaling pathway
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of vascular endothelial growth factor receptor signaling pathway activity." [GOC:dgh]


id: GO:0030949
name: positive regulation of vascular endothelial growth factor receptor signaling pathway
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of vascular endothelial growth factor receptor signaling pathway activity." [GOC:dgh]


id: GO:0030950
name: establishment or maintenance of actin cytoskeleton polarity
namespace: biological_process
def:
  "Any cellular process that results in the specification, formation or maintenance of polarized actin-based cytoskeletal structures." [GOC:mah]


id: GO:0030951
name: establishment or maintenance of microtubule cytoskeleton polarity
namespace: biological_process
def:
  "Any cellular process that results in the specification, formation or maintenance of polarized microtubule-based cytoskeletal structures." [GOC:mah]


id: GO:0030952
name: establishment or maintenance of cytoskeleton polarity
namespace: biological_process
def:
  "Any cellular process that results in the specification, formation or maintenance of polarized cytoskeletal structures." [GOC:mah]


id: GO:0030953
name: astral microtubule organization
namespace: biological_process
def:
  "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of astral microtubules, any of the spindle microtubules that radiate in all directions from the spindle poles." [GOC:mah]


id: GO:0030954
name: astral microtubule nucleation
namespace: biological_process
def:
  "The 'de novo' formation of an astral microtubule, in which tubulin heterodimers form metastable oligomeric aggregates, some of which go on to support formation of a complete microtubule." [GOC:mah]


id: GO:0030956
name: glutamyl-tRNA(Gln) amidotransferase complex
namespace: cellular_component
def:
  "A protein complex that possesses glutamyl-tRNA(Gln) amidotransferase activity, and therefore creates Gln-tRNA by amidating Glu-tRNA; usually composed of 3 subunits: A, B, and C. Note that the C subunit may not be required in all organisms." [GOC:mlg]


id: GO:0030957
name: Tat protein binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with Tat, a viral transactivating regulatory protein from the human immunodeficiency virus, or the equivalent protein from another virus." [GOC:mah, PMID:9094689]


id: GO:0030958
name: RITS complex
namespace: cellular_component
def:
  "A protein complex required for heterochromatin assembly; contains an Argonaute homolog, a chromodomain protein, and at least one additional protein; named for RNA-induced initiation of transcriptional gene silencing." [PMID:14704433]


id: GO:0030959
name: peptide cross-linking via 3'-(3'-L-tyrosinyl)-L-tyrosine
namespace: biological_process
def:
  "The modification of two peptidyl-tyrosines to form a 3'-(3'-L-tyrosinyl)-L-tyrosine protein cross-link." [RESID:AA0367]


id: GO:0030960
name: peptide cross-linking via 3'-(O4'-L-tyrosinyl)-L-tyrosine
namespace: biological_process
def:
  "The modification of two peptidyl-tyrosines to form a 3'-(O4'-L-tyrosinyl)-L-tyrosine protein cross-link." [PDB:1NGK, PMID:12719529, RESID:AA0368]


id: GO:0030962
name: peptidyl-arginine dihydroxylation to peptidyl-3,4-dihydroxy-L-arginine
namespace: biological_process
def:
  "The dihydroxylation of peptidyl-arginine to form peptidyl-3,4-dihydroxy-L-arginine." [PMID:10978343, RESID:AA0369]


id: GO:0030963
name: peptidyl-lysine dihydroxylation to 4,5-dihydroxy-L-lysine
namespace: biological_process
def:
  "The dihydroxylation of peptidyl-lysine to peptidyl-4,5-dihydroxy-L-lysine." [PMID:10978343, RESID:AA0370]


id: GO:0030964
name: NADH dehydrogenase complex
namespace: cellular_component
def:
  "An integral membrane complex that possesses NADH oxidoreductase activity. The complex is one of the components of the electron transport chain. It catalyzes the transfer of a pair of electrons from NADH to a quinone." [GOC:mah]


id: GO:0030965
name: plasma membrane electron transport, NADH to quinone
namespace: biological_process
def:
  "The transfer of electrons from NADH to the quinone pool that occurs during oxidative phosphorylation and results in the generation of a proton gradient, mediated by the enzyme known as NADH-quinone oxidoreductase." [GOC:mah, GOC:sd]


id: GO:0030968
name: endoplasmic reticulum unfolded protein response
namespace: biological_process
def:
  "The series of molecular signals generated as a consequence of the presence of unfolded proteins in the endoplasmic reticulum (ER) or other ER-related stress; results in changes in the regulation of transcription and translation." [GOC:mah, PMID:12042763]


id: GO:0030969
name: mRNA splicing via endonucleolytic cleavage and ligation involved in unfolded protein response
namespace: biological_process
def:
  "The spliceosome-independent cleavage and ligation of the mRNA encoding a UFP-specific transcription factor to remove a single intron, thereby increasing both the translational efficiency of the processed mRNA and the activity of the protein it encodes." [GOC:mah, PMID:12042763, PMID:21924241]


id: GO:0030970
name: retrograde protein transport, ER to cytosol
namespace: biological_process
def:
  "The directed movement of unfolded or misfolded proteins from the endoplasmic reticulum to the cytosol through the translocon." [PMID:11994744]


id: GO:0030971
name: receptor tyrosine kinase binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with a receptor that possesses protein tyrosine kinase activity." [GOC:mah]


id: GO:0030972
name: obsolete cleavage of cytosolic proteins involved in execution phase of apoptosis
namespace: biological_process
def:
  "OBSOLETE. The proteolytic degradation of proteins in the cytosol that contributes to apoptosis." [GOC:dph, GOC:mah, GOC:mtg_apoptosis, GOC:tb, ISBN:0815332181]


id: GO:0030974
name: thiamine pyrophosphate transport
namespace: biological_process
def:
  "The directed movement of thiamine pyrophosphate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mlg]


id: GO:0030975
name: thiamine binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with thiamine (vitamin B1), a water soluble vitamin present in fresh vegetables and meats, especially liver." [GOC:mlg]


id: GO:0030976
name: thiamine pyrophosphate binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with thiamine pyrophosphate, the diphosphoric ester of thiamine. Acts as a coenzyme of several (de)carboxylases, transketolases, and alpha-oxoacid dehydrogenases." [CHEBI:45931, GOC:mlg]


id: GO:0030978
name: alpha-glucan metabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways involving alpha-glucans, compounds composed of glucose residues linked by alpha-D-glucosidic bonds." [GOC:mah]


id: GO:0030979
name: alpha-glucan biosynthetic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the formation of alpha-glucans, compounds composed of glucose residues linked by alpha-D-glucosidic bonds." [GOC:mah]


id: GO:0030982
name: adventurous gliding motility
namespace: biological_process
def:
  "A process involved in the controlled movement of a bacterial cell powered by the rearward secretion of carbohydrate slime." [GOC:mlg, PMID:11967173]


id: GO:0030983
name: mismatched DNA binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with double-stranded DNA containing one or more mismatches." [GOC:mah]


id: GO:0030984
name: kininogen binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with a kininogen, any of a group of plasma proteins that are kinin precursors." [GOC:mah, PMID:9520414]


id: GO:0030985
name: high molecular weight kininogen binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with a kininogen of high molecular mass." [GOC:mah, PMID:9520414]


id: GO:0030986
name: low molecular weight kininogen binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with a kininogen of low molecular mass." [GOC:mah, PMID:9520414]


id: GO:0030987
name: high molecular weight kininogen receptor binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with a high molecular weight kininogen receptor." [GOC:mah]


id: GO:0030988
name: high molecular weight kininogen receptor complex
namespace: cellular_component
def:
  "A protein complex that acts as a receptor for high molecular weight kininogens. In humans, this receptor includes the CK1 and uPAR proteins." [GOC:mah, PMID:11290596]


id: GO:0030989
name: dynein-driven meiotic oscillatory nuclear movement
namespace: biological_process
def:
  "Oscillatory movement of the nucleus involved in meiosis I. This oscillatory movement is led by an astral microtubule array emanating from the spindle pole body, and driven by the microtubule motor cytoplasmic dynein." [GOC:vw, PMID:16111942, PMID:9572142]


id: GO:0030990
name: intraciliary transport particle
namespace: cellular_component
def:
  "A nonmembrane-bound oligomeric protein complex that participates in bidirectional transport of molecules (cargo) along axonemal microtubules." [GOC:cilia, GOC:kmv, PMID:14570576, PMID:22118932, PMID:23945166]


id: GO:0030991
name: intraciliary transport particle A
namespace: cellular_component
def:
  "The smaller subcomplex of the intraciliary transport particle; characterized complexes have molecular weights of 710-760 kDa." [GOC:cilia, GOC:kmv, PMID:14570576]


id: GO:0030992
name: intraciliary transport particle B
namespace: cellular_component
def:
  "The larger subcomplex of the intraciliary transport particle; characterized complexes have molecular weights around 550 kDa." [GOC:cilia, GOC:kmv, PMID:14570576, PMID:19253336]


id: GO:0030993
name: axonemal heterotrimeric kinesin-II complex
namespace: cellular_component
def:
  "A kinesin complex found in eukaryotic axonemes that contains two distinct plus end-directed kinesin motor proteins and at least one accessory subunit, and that functions in the anterograde transport of molecules (cargo) from the basal body to the distal tip of the axoneme." [GOC:kmv, PMID:14570576]


id: GO:0030995
name: cell septum edging catabolic process
namespace: biological_process
def:
  "The chemical reactions and pathways resulting in the dissolution of the septum edging during cell separation." [GOC:mah, PMID:15194814]


id: GO:0030996
name: obsolete mitotic cell cycle arrest in response to nitrogen starvation
namespace: biological_process
def:
  "OBSOLETE. The process in which the mitotic cell cycle is halted during one of the normal phases (G1, S, G2, M) as a result of deprivation of nitrogen." [GOC:dph, GOC:mah, GOC:tb, GOC:vw]


id: GO:0030997
name: regulation of centriole-centriole cohesion
namespace: biological_process
def:
  "Any process that modulates the extent to which the two centrioles within a centrosome remain tightly paired; may be mediated by the assembly and disassembly of a proteinaceous linker." [PMID:11076968]


id: GO:0030998
name: linear element
namespace: cellular_component
def:
  "A proteinaceous scaffold associated with S. pombe chromosomes during meiotic prophase. Linear elements have a structure related to but not equivalent to the synaptonemal complex." [GOC:jb]


id: GO:0030999
name: linear element assembly
namespace: biological_process
def:
  "The cell cycle process in which a proteinaceous scaffold, related to the synaptonemal complex, is assembled in association with S. pombe chromosomes during meiotic prophase." [GOC:jb, GOC:mah]


id: GO:0031000
name: response to caffeine
namespace: biological_process
def:
  "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a caffeine stimulus. Caffeine is an alkaloid found in numerous plant species, where it acts as a natural pesticide that paralyzes and kills certain insects feeding upon them." [CHEBI:27732, GOC:ef, GOC:mah]


id: GO:0031001
name: response to brefeldin A
namespace: biological_process
def:
  "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a brefeldin A stimulus." [GOC:mah]


id: GO:0031002
name: actin rod
namespace: cellular_component
def:
  "A cellular structure consisting of parallel, hexagonally arranged actin tubules, comprising filamentous actin and associated proteins. Found in the germinating spores of Dictyostelium discoideum." [GOC:kp]


id: GO:0031003
name: actin tubule
namespace: cellular_component
def:
  "A cellular structure, approximately 13 nm in diameter, consisting of three actin filaments bundled together." [GOC:kp]


id: GO:0031004
name: potassium ion-transporting ATPase complex
namespace: cellular_component
def:
  "Protein complex that carries out the reaction: ATP + H2O + K+(out) = ADP + phosphate + K+(in). It is a high affinity potassium uptake system. The E. coli complex consists of 4 proteins: KdpA is the potassium ion translocase, KdpB is the ATPase, and KdpC and KdpF seem to be involved in assembly and stabilization of the complex." [PMID:10608856, PMID:9858692, TIGR_TIGRFAMS:TIGR01497]


id: GO:0031005
name: filamin binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with a filamin, any member of a family of high molecular mass cytoskeletal proteins that crosslink actin filaments to form networks and stress fibers. Filamins contain an amino-terminal alpha-actinin-like actin binding domain, which is followed by a rod-domain composed of 4 to 24 100-residue repetitive segments including a carboxy-terminal dimerization domain." [GOC:mah, PMID:11336782]


id: GO:0031010
name: ISWI-type complex
namespace: cellular_component
def:
  "Any nuclear protein complex that contains an ATPase subunit of the imitation switch (ISWI) family. ISWI ATPases are involved in assembling chromatin and in sliding and spacing nucleosomes to regulate transcription of nuclear RNA polymerases I, II, and III and also DNA replication, recombination and repair." [GOC:krc, GOC:mah, PMID:15020051, PMID:15284901, PMID:16568949, PMID:21810179]


id: GO:0031011
name: Ino80 complex
namespace: cellular_component
def:
  "A multisubunit protein complex that contains the Ino80p ATPase; exhibits chromatin remodeling activity and 3' to 5' DNA helicase activity." [GOC:jh, GOC:rb, PMID:19355820]


id: GO:0031012
name: extracellular matrix
namespace: cellular_component
def:
  "A structure lying external to one or more cells, which provides structural support for cells or tissues; may be completely external to the cell (as in animals and bacteria) or be part of the cell (as in plants)." [GOC:mah, NIF_Subcellular:nlx_subcell_20090513]


id: GO:0031013
name: troponin I binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with troponin I, the inhibitory subunit of the troponin complex." [GOC:mah, ISBN:0815316194]


id: GO:0031014
name: troponin T binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with troponin T, the tropomyosin-binding subunit of the troponin complex." [GOC:mah, ISBN:0815316194]


id: GO:0031015
name: obsolete karyopherin docking complex
namespace: cellular_component
def:
  "OBSOLETE. A subcomplex of the nuclear pore complex that interacts with karyopherin-cargo complexes; a well-characterized example in Saccharomyces contains Asm4p, Nup53p, and Nup170p." [PMID:11867631, PMID:9864357]


id: GO:0031016
name: pancreas development
namespace: biological_process
def:
  "The process whose specific outcome is the progression of the pancreas over time, from its formation to the mature structure. The pancreas is an endoderm derived structure that produces precursors of digestive enzymes and blood glucose regulating enzymes." [GOC:cvs]


id: GO:0031017
name: exocrine pancreas development
namespace: biological_process
def:
  "The process whose specific outcome is the progression of the exocrine pancreas over time, from its formation to the mature structure. The exocrine pancreas produces and store zymogens of digestive enzymes, such as chymotrypsinogen and trypsinogen in the acinar cells." [GOC:cvs]


id: GO:0031018
name: endocrine pancreas development
namespace: biological_process
def:
  "The process whose specific outcome is the progression of the endocrine pancreas over time, from its formation to the mature structure. The endocrine pancreas is made up of islet cells that produce insulin, glucagon and somatostatin." [GOC:cvs]


id: GO:0031019
name: mitochondrial mRNA editing complex
namespace: cellular_component
def:
  "An mRNA editing complex found in the mitochondrion. The best characterized example is that of Trypanosoma brucei, which catalyzes the insertion and deletion of uridylates." [GOC:mah, PMID:12139607]


id: GO:0031021
name: interphase microtubule organizing center
namespace: cellular_component
def:
  "A microtubule organizing center found in interphase cells, which organize a longitudinal array of three to five MT bundles from the nuclear envelope during interphase. Each MT bundle is composed of two to seven MTs arranged in an antiparallel configuration, with the dynamic MT plus ends extending toward the cell tips and stable minus ends near the nucleus." [PMID:15068790]


id: GO:0031022
name: nuclear migration along microfilament
namespace: biological_process
def:
  "The directed movement of the nucleus along microfilaments within the cell, mediated by motor proteins." [GOC:mah]


id: GO:0031023
name: microtubule organizing center organization
namespace: biological_process
def:
  "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a microtubule organizing center, a structure from which microtubules grow." [GOC:dph, GOC:jl, GOC:mah]


id: GO:0031024
name: interphase microtubule organizing center assembly
namespace: biological_process
def:
  "The aggregation, arrangement and bonding together of a set of components, including gamma-tubulin and other proteins, to form an interphase microtubule organizing center." [GOC:mah, PMID:15068790]


id: GO:0031025
name: equatorial microtubule organizing center disassembly
namespace: biological_process
def:
  "The process in which the equatorial microtubule organizing center is disassembled at the end of mitosis." [GOC:mah, PMID:15068790]


id: GO:0031027
name: glutamate synthase complex (NADH)
namespace: cellular_component
def:
  "A protein complex that in yeast consists of a large and a small subunit. Possesses glutamate synthase (NADH) activity." [GOC:jl, PMID:7047525]


id: GO:0031028
name: septation initiation signaling
namespace: biological_process
def:
  "The series of molecular signals, mediated by the small GTPase Ras, that results in the initiation of contraction of the contractile ring, at the beginning of cytokinesis and cell division by septum formation. The pathway coordinates chromosome segregation with mitotic exit and cytokinesis." [GOC:mah, GOC:vw, PMID:16775007]


id: GO:0031029
name: regulation of septation initiation signaling
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of septation initiation signaling." [GOC:mah]


id: GO:0031030
name: negative regulation of septation initiation signaling
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of septation initiation signaling." [GOC:mah]


id: GO:0031031
name: positive regulation of septation initiation signaling
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of septation initiation signaling." [GOC:mah]


id: GO:0031032
name: actomyosin structure organization
namespace: biological_process
def:
  "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures containing both actin and myosin or paramyosin. The myosin may be organized into filaments." [GOC:dph, GOC:jl, GOC:mah]


id: GO:0031033
name: myosin filament organization
namespace: biological_process
def:
  "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a filament composed of myosin molecules." [GOC:mah]


id: GO:0031034
name: myosin filament assembly
namespace: biological_process
def:
  "The aggregation, arrangement and bonding together of a filament composed of myosin molecules." [GOC:mah]


id: GO:0031038
name: myosin II filament organization
namespace: biological_process
def:
  "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a bipolar filament composed of myosin II molecules." [GOC:mah]


id: GO:0031039
name: macronucleus
namespace: cellular_component
def:
  "A membrane-bounded organelle of ciliated protozoan cells that contains polyploid copies of a portion of the cell's complete genome. Transcription of genes occurs in macronuclei. Some ciliate species may contain multiple macronuclei per cell." [GOC:ns]


id: GO:0031040
name: micronucleus
namespace: cellular_component
def:
  "A membrane-bounded organelle of ciliated protozoan cells that contains a diploid copy of the cell's complete genome. Sections of contiguous sequence in the macronucleus are often interrupted by internal eliminated sequences (IES), and may be permuted, in micronuclei. Genic transcription is not found in micronuclei. Some ciliate species may contain multiple micronuclei per cell." [GOC:ns]


id: GO:0031041
name: O-glycan processing, core 5
namespace: biological_process
def:
  "The stepwise addition of carbohydrate or carbohydrate derivative residues to the initially added O-linked residue (usually GalNAc) to form the core 5 O-glycan structure, GalNAc-alpha-(1->3)-GalNAc." [GOC:mah, GOC:pr, PMID:10580130]


id: GO:0031042
name: O-glycan processing, core 6
namespace: biological_process
def:
  "The stepwise addition of carbohydrate or carbohydrate derivative residues to the initially added O-linked residue (usually GalNAc) to form the core 6 O-glycan structure, GlcNAc-beta-(1->6)-GalNAc." [GOC:mah, GOC:pr, PMID:10580130]


id: GO:0031043
name: O-glycan processing, core 7
namespace: biological_process
def:
  "The stepwise addition of carbohydrate or carbohydrate derivative residues to the initially added O-linked residue (usually GalNAc) to form the core 7 O-glycan structure, GalNAc-alpha-(1->6)-GalNAc." [GOC:mah, GOC:pr, PMID:10580130]


id: GO:0031044
name: O-glycan processing, core 8
namespace: biological_process
def:
  "The stepwise addition of carbohydrate or carbohydrate derivative residues to the initially added O-linked residue (usually GalNAc) to form the core 8 O-glycan structure, Gal-alpha-(1->3)-GalNAc." [GOC:mah, GOC:pr, PMID:10580130]


id: GO:0031045
name: dense core granule
namespace: cellular_component
def:
  "Electron-dense organelle with a granular internal matrix; contains proteins destined to be secreted." [NIF_Subcellular:sao772007592, PMID:14690495]


id: GO:0031047
name: gene silencing by RNA
namespace: biological_process
def:
  "Any process in which RNA molecules inactivate expression of target genes." [GOC:dph, GOC:mah, GOC:tb, PMID:15020054]


id: GO:0031048
name: chromatin silencing by small RNA
namespace: biological_process
def:
  "Repression of transcription by conversion of large regions of DNA into heterochromatin, directed by small RNAs sharing sequence identity to the repressed region." [GOC:dph, GOC:mtg_lung, GOC:ns]


id: GO:0031049
name: programmed DNA elimination
namespace: biological_process
def:
  "The DNA metabolic process in which micronuclear-limited sequences, internal eliminated sequences (IES) and breakage eliminated sequences (BES) are removed from the developing macronucleus (anlage) of a ciliate." [GOC:mah, GOC:ns]


id: GO:0031050
name: dsRNA fragmentation
namespace: biological_process
def:
  "Cleavage of double-stranded RNA molecules by an RNaseIII-family enzyme to produce small RNAs (generally 20-30 nucleotides, depending on species) with biological function." [GOC:ns]


id: GO:0031051
name: scnRNA production
namespace: biological_process
def:
  "Cleavage of noncoding, double-stranded RNAs transcribed from the micronuclear genome to produce scnRNAs, small RNAs (~28 nucleotides) that direct the deletion of micronuclear-limited sequences from the developing macronuclear genome." [PMID:15196465]


id: GO:0031052
name: chromosome breakage
namespace: biological_process
def:
  "Regulated cleavage of the developing macronuclear genome at a limited number of chromosome breakage sites (CBS). The macronuclear destined segment (MDS) sequence adjacent to the CBS (or separated from it by a BES) receives a macronuclear telomere following chromosome breakage." [GOC:ns]


id: GO:0031053
name: primary miRNA processing
namespace: biological_process
def:
  "Any process involved in the conversion of a primary microRNA transcript into a pre-microRNA molecule." [GOC:sl, PMID:15211354]


id: GO:0031054
name: pre-miRNA processing
namespace: biological_process
def:
  "Any process involved in the conversion of a pre-microRNA transcript into a mature microRNA molecule." [GOC:sl, PMID:15211354]


id: GO:0031056
name: regulation of histone modification
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of the covalent alteration of a histone." [GOC:mah]


id: GO:0031057
name: negative regulation of histone modification
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of the covalent alteration of a histone." [GOC:mah]


id: GO:0031058
name: positive regulation of histone modification
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of the covalent alteration of a histone." [GOC:mah]


id: GO:0031060
name: regulation of histone methylation
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of the covalent addition of methyl groups to histones." [GOC:mah]


id: GO:0031061
name: negative regulation of histone methylation
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of the covalent addition of methyl groups to histones." [GOC:mah]


id: GO:0031062
name: positive regulation of histone methylation
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of the covalent addition of methyl groups to histones." [GOC:mah]


id: GO:0031063
name: regulation of histone deacetylation
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of the removal of acetyl groups from histones." [GOC:mah]


id: GO:0031064
name: negative regulation of histone deacetylation
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of the removal of acetyl groups from histones." [GOC:mah]


id: GO:0031065
name: positive regulation of histone deacetylation
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of the removal of acetyl groups from histones." [GOC:mah]


id: GO:0031066
name: regulation of histone deacetylation at centromere
namespace: biological_process
def:
  "Any process that modulates the frequency, rate or extent of the removal of acetyl groups from histones in centromeric DNA." [GOC:mah]


id: GO:0031067
name: negative regulation of histone deacetylation at centromere
namespace: biological_process
def:
  "Any process that stops, prevents, or reduces the frequency, rate or extent of the removal of acetyl groups to histones in centromeric DNA." [GOC:mah]


id: GO:0031068
name: positive regulation of histone deacetylation at centromere
namespace: biological_process
def:
  "Any process that activates or increases the frequency, rate or extent of the removal of acetyl groups from histones in centromeric DNA." [GOC:mah]


id: GO:0031069
name: hair follicle morphogenesis
namespace: biological_process
def:
  "The process in which the anatomical structures of the hair follicle are generated and organized." [GOC:ln]


id: GO:0031070
name: intronic snoRNA processing
namespace: biological_process
def:
  "The biogenesis of a snoRNA molecule which resides within, and is processed from, the intron of a pre-mRNA." [GOC:vw]


id: GO:0031071
name: cysteine desulfurase activity
namespace: molecular_function
def:
  "Catalysis of the reaction: L-cysteine + [enzyme]-cysteine = L-alanine + [enzyme]-S-sulfanylcysteine." [EC:2.8.1.7]


id: GO:0031072
name: heat shock protein binding
namespace: molecular_function
def:
  "Interacting selectively and non-covalently with a heat shock protein, any protein synthesized or activated in response to heat shock." [GOC:mah, GOC:vw]


id: GO:0031073
name: cholesterol 26-hydroxylase activity
namespace: molecular_function
def:
  "Catalysis of the hydroxylation of cholesterol at position 26 of the side chain, to produce 26-hydroxycholesterol." [GOC:mah, PMID:950499]


id: GO:0031074
name: nucleocytoplasmic shuttling complex
namespace: cellular_component
def:
  "Any complex that acts to move proteins or RNAs into or out of the nucleus through nuclear pores." [GOC:mah]


id: GO:0031076
name: embryonic camera-type eye development
namespace: biological_process
def:
  "The process occurring during the embryonic phase whose specific outcome is the progression of the eye over time, from its formation to the mature structure." [GOC:mah, GOC:mtg_sensu]


id: GO:0031077
name: post-embryonic camera-type eye development
namespace: biological_process
def:
  "The process occurring during the post-embryonic phase whose specific outcome is the progression of the camera-type eye over time, from its formation to the mature structure." [GOC:mah, GOC:mtg_sensu]


id: GO:0031078
name: histone deacetylase activity (H3-K14 specific)
namespace: molecular_function
def:
  "Catalysis of the reaction: histone H3 N6-acetyl-L-lysine (position 14) + H2O = histone H3 L-lysine (position 14) + acetate. This reaction represents the removal of an acetyl group from lysine at position 14 of the histone H3 protein." [EC:3.5.1.17, RHEA:24551]


id: GO:0031079
name: obsolete picornain 3C activity
namespace: molecular_function
def:
  "OBSOLETE. Catalysis of the selective cleavage of GlnGly bond in the poliovirus polyprotein. In other picornavirus reactions Glu may be substituted for Gln, and Ser or Thr for Gly." [EC:3.4.22.28]


